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Bingsen Zhou

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Chemicals & Drugs

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Physiology

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Publications

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Xiyong Liu; Sofia Loera; Rebecca A Nelson; Xiaochen Wang; Lijun Xue; Peiguo Chu; Huiyin He; Shuya Hu; Yasheng Huang; Lily Lai; Hang Zhang; Keqiang Zhang; Suzhan Zhang; Shu Zheng; Bingsen Zhou; Lun Zhou; Yun Yen
Ribonucleotide reductase small subunit M2 serves as a prognostic biomarker and predicts poor survival of colorectal cancers.
Frank Un; Bingsen Zhou; Yun Yen
The utility of tumor-specifically internalizing peptides for targeted siRNA delivery into human solid tumors.
Shikha Gaur; Yafan Wang; Terence Yen; Linling Chen; Mark Davis; Bingsen Zhou; Yun Yen
Preclinical study of the cyclodextrin-polymer conjugate of camptothecin CRLX101 for the treatment of gastric cancer.

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All Publications

2013: Xiyong Liu; Sofia Loera; Rebecca A Nelson; Xiaochen Wang; Lijun Xue; Peiguo Chu; Huiyin He; Shuya Hu; Yasheng Huang; Lily Lai; Hang Zhang; Keqiang Zhang; Suzhan Zhang; Shu Zheng; Bingsen Zhou; Lun Zhou; Yun Yen
Ribonucleotide reductase small subunit M2 serves as a prognostic biomarker and predicts poor survival of colorectal cancers.
Clinical science (London, England : 1979) 2013;124(9):567-78.
2012: Frank Un; Bingsen Zhou; Yun Yen
The utility of tumor-specifically internalizing peptides for targeted siRNA delivery into human solid tumors.
Anticancer research 2012;32(11):4685-90.
2012: Shikha Gaur; Yafan Wang; Terence Yen; Linling Chen; Mark Davis; Bingsen Zhou; Yun Yen
Preclinical study of the cyclodextrin-polymer conjugate of camptothecin CRLX101 for the treatment of gastric cancer.
Nanomedicine : nanotechnology, biology, and medicine 2012;8(5):721-30.
2012: Mohammad Aminur Rahman; A R M Ruhul Amin; Zhengjia Chen; Zhuo Georgia Chen; Chung Hang J Choi; Mark E Davis; Lydia Koenig; Sreenivas Nannapaneni; Dongsheng Wang; Xu Wang; Yun Yen; Bingsen Zhou; Jonathan E Zuckerman; Dong M Shin
Systemic delivery of siRNA nanoparticles targeting RRM2 suppresses head and neck tumor growth.
Journal of controlled release : official journal of the Controlled Release Society 2012;159(3):384-92.
2011: Xiaochen Wang; Lijun Xue; Keqiang Zhang; Suzhan Zhang; Bingsen Zhou; David Ann; Shuya Hu; Mei-Ling Kuo; Xiyong Liu; Yun Yen
Ribonucleotide reductase subunit p53R2 regulates mitochondria homeostasis and function in KB and PC-3 cancer cells.
Biochemical and biophysical research communications 2011;410(1):102-7.
2011: Xiyong Liu; Lily Lai; Xiaochen Wang; Lijun Xue; Sofia Leora; Jun Wu; Shuya Hu; Keqiang Zhang; Mei-Ling Kuo; Lun Zhou; Hang Zhang; Yan Wang; Yan Wang; Bingsen Zhou; Rebecca A Nelson; Shu Zheng; Suzhan Zhang; Peiguo Chu; Yun Yen
Ribonucleotide reductase small subunit M2B prognoses better survival in colorectal cancer.
Cancer research 2011;71(9):3202-13.
2011: Loredana Cappellacci; Riccardo Petrelli; Palmarisa Franchetti; Patrizia Vita; Praveen Kusumanchi; Mohineesh Kumar; Hiremagalur N Jayaram; Bingsen Zhou; Yun Yen; Mario Grifantini
Synthesis and biological activity of novel N6-substituted and 2,N6-disubstituted adenine ribo- and 3'-C-methyl-ribonucleosides as antitumor agents.
European journal of medicinal chemistry 2011;46(5):1499-504.
2011: Xiaochen Wang; Xiyong Liu; Angela Ying-Jian Li; Lirong Chen; Lily Lai; Her Helen Lin; Shuya Hu; Lifang Yao; Jiaping Peng; Sofia Loera; Lijun Xue; Bingsen Zhou; Lun Zhou; Shu Zheng; Peiguo Chu; Suzhan Zhang; David Kong Ann; Yun Yen
Overexpression of HMGA2 promotes metastasis and impacts survival of colorectal cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(8):2570-80.
2011: Keqiang Zhang; Jun Wu; Xiwei Wu; Xiaochen Wang; Yan Wang; Ning Zhou; Mei-ling Kuo; Xiyong Liu; Bingsen Zhou; Lufen Chang; David K Ann; Yun Yen
p53R2 inhibits the proliferation of human cancer cells in association with cell-cycle arrest.
Molecular cancer therapeutics 2011;10(2):269-78.
2010: Bingsen Zhou; Leila Su; Yate-Ching Yuan; Frank Un; Norby Wang; Madhukar Patel; Bixin Xi; Shuya Hu; Yun Yen
Structural basis on the dityrosyl-diiron radical cluster and the functional differences of human ribonucleotide reductase small subunits hp53R2 and hRRM2.
Molecular cancer therapeutics 2010;9(6):1669-79.
2010: Brent J Passer; Tooba Cheema; Bingsen Zhou; Hiroaki Wakimoto; Cecile Zaupa; Mani Razmjoo; Jason Sarte; Shulin Wu; Chin-Lee Wu; James W Noah; Qianjun Li; John K Buolamwini; Yun Yen; Samuel D Rabkin; Robert L Martuza
Identification of the ENT1 antagonists dipyridamole and dilazep as amplifiers of oncolytic herpes simplex virus-1 replication.
Cancer research 2010;70(10):3890-5.
2009: Peter Smith; Bingsen Zhou; Nam Ho; Yate-Ching Yuan; Leila Su; Shiou-Chuan Tsai; Yun Yen
2.6 A X-ray crystal structure of human p53R2, a p53-inducible ribonucleotide reductase .
Biochemistry 2009;48(46):11134-41.
2009: Lijun Zhu; Bingsen Zhou; Xinhuan Chen; Hongjuan Jiang; Jimin Shao; Yun Yen
Inhibitory mechanisms of heterocyclic carboxaldehyde thiosemicabazones for two forms of human ribonucleotide reductase.
Biochemical pharmacology 2009;78(9):1178-85.
2009: Min Guan; Lijun Zhu; George Somlo; Alison Hughes; Bingsen Zhou; Yun Yen
Bortezomib therapeutic effect is associated with expression of FGFR3 in multiple myeloma cells.
Anticancer research 2009;29(1):1-9.
2009: Keqiang Zhang; Shuya Hu; Jun Wu; Linling Chen; Jianming Lu; Xiaochen Wang; Xiyong Liu; Bingsen Zhou; Yun Yen
Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesis.
Molecular cancer 2009;8():11.
2008: Kesavan Krishnan; Kumari Prathiba; Venkatesan Jayaprakash; Arijit Basu; Nibha Mishra; Bingsen Zhou; Shuya Hu; Yun Yen
Synthesis and ribonucleotide reductase inhibitory activity of thiosemicarbazones.
Bioorganic & medicinal chemistry letters 2008;18(23):6248-50.
2008: Lufen Chang; Bingsen Zhou; Shuya Hu; Robin Guo; Xiyong Liu; Stephen N Jones; Yun Yen
ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(47):18519-24.
2007: Chunling Jiang; Bingsen Zhou; Kenneth Fan; Eric Heung; Lijun Xue; Xiyong Liu; Mark Kirschbaum; Yun Yen
A sequential treatment of depsipeptide followed by 5-azacytidine enhances Gadd45beta expression in hepatocellular carcinoma cells.
Anticancer research 2007;27(6B):3783-9.
2007: Weihua Qiu; Bingsen Zhou; Peiguo G Chu; Frank Luh; Yun Yen
The induction of growth arrest DNA damage-inducible gene 45 beta in human hepatoma cell lines by S-adenosylmethionine.
The American journal of pathology 2007;171(1):287-96.
2007: Xiyong Liu; Bingsen Zhou; Shu Mi; Lijun Xue; Jennifer Shih; Janice Lee; Jennifer Chau; Frank Un; Yun Yen
An increase of cytochrome C oxidase mediated disruption of gemcitabine incorporation into DNA in a resistant KB clone.
Biochemical pharmacology 2007;73(12):1927-38.
2007: Jeremy D Heidel; Joanna Yi-Ching Liu; Yun Yen; Bingsen Zhou; Bret Heale; John J Rossi; Derek W Bartlett; Mark E Davis
Potent siRNA inhibitors of ribonucleotide reductase subunit RRM2 reduce cell proliferation in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(7):2207-15.
2007: Xiyong Liu; Bingsen Zhou; Lijun Xue; Frank Yen; Peiguo Chu; Frank Un; Yun Yen
Ribonucleotide reductase subunits M2 and p53R2 are potential biomarkers for metastasis of colon cancer.
Clinical colorectal cancer 2007;6(5):374-81.
2007: Lijun Xue; Bingsen Zhou; Xiyong Liu; Yvonne Heung; Jennifer Chau; Emilie Chu; Shan Li; Chunglin Jiang; Frank Un; Yun Yen
Ribonucleotide reductase small subunit p53R2 facilitates p21 induction of G1 arrest under UV irradiation.
Cancer research 2007;67(1):16-21.
2006: Xiyong Liu; Bingsen Zhou; Lijun Xue; Jennifer Shih; Karen Tye; Wesley Lin; Christina Qi; Peiguo Chu; Frank Un; Wei Wen; Yun Yen
Metastasis-suppressing potential of ribonucleotide reductase small subunit p53R2 in human cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(21):6337-44.
2006: Bingsen Zhou; Vu Phan; Xiyong Liu; Agnes Juhasz; Peiguo G Chu; Yun Yen
Production of a monoclonal antibody against the hRRM2 subunit of ribonucleotide reductase and immunohistochemistry study of human cancer tissues.
Hybridoma (2005) 2006;25(5):264-70.
2006: Jimin Shao; Bingsen Zhou; Bernard Chu; Yun Yen
Ribonucleotide reductase inhibitors and future drug design.
Current cancer drug targets 2006;6(5):409-31.
2006: Frank Un; Christina Qi; Megan Prosser; Norby Wang; Bingsen Zhou; Christian BRONNER; Yun Yen
Modulating ICBP90 to suppress human ribonucleotide reductase M2 induction restores sensitivity to hydroxyurea cytotoxicity.
Anticancer research 2006;26(4B):2761-7.
2006: Jimin Shao; Bingsen Zhou; Angel J Di Bilio; Lijun Zhu; Tieli Wang; Christina Qi; Jennifer Shih; Yun Yen
A Ferrous-Triapine complex mediates formation of reactive oxygen species that inactivate human ribonucleotide reductase.
Molecular cancer therapeutics 2006;5(3):586-92.
2006: Vincent Chung; Bingsen Zhou; Xiyong Liu; Lijun Zhu; Lee Ming Boo; Ha-Van Nguyen; David K Ann; Jing Song; Yuan Chen; Yun Yen
SUMOylation plays a role in gemcitabine- and bortezomib-induced cytotoxicity in human oropharyngeal carcinoma KB gemcitabine-resistant clone.
Molecular cancer therapeutics 2006;5(3):533-40.
2006: Lijun Xue; Bingsen Zhou; Xiyong Liu; Tieli Wang; Jennifer Shih; Christina Qi; Yvonne Heung; Yun Yen
Structurally dependent redox property of ribonucleotide reductase subunit p53R2.
Cancer research 2006;66(4):1900-5.
2006: Weihua Qiu; Bingsen Zhou; Dana Darwish; Jimin Shao; Yun Yen
Characterization of enzymatic properties of human ribonucleotide reductase holoenzyme reconstituted in vitro from hRRM1, hRRM2, and p53R2 subunits.
Biochemical and biophysical research communications 2006;340(2):428-34.
2006: Yun Yen; Bernard Chu; Christina Yen; Jennifer Shih; Bingsen Zhou
Enzymatic property analysis of p53R2 subunit of human ribonucleotide reductase.
Advances in enzyme regulation 2006;46():235-47.
2005: Bingsen Zhou; Jimin Shao; Leila Su; Yate-Ching Yuan; Christina Qi; Jennifer Shih; Bixin Xi; Bernard Chu; Yun Yen
A dityrosyl-diiron radical cofactor center is essential for human ribonucleotide reductases.
Molecular cancer therapeutics 2005;4(12):1830-6.
2005: Xiyong Liu; Bingsen Zhou; Lijun Xue; Jennifer Shih; Karen Tye; Christina Qi; Yun Yen
The ribonucleotide reductase subunit M2B subcellular localization and functional importance for DNA replication in physiological growth of KB cells.
Biochemical pharmacology 2005;70(9):1288-97.
2005: Shenxian Qian; George Somlo; Bingsen Zhou; Yun Yen
Therapeutic effects of thalidomide in myeloma are associated with the expression of fibroblast growth factor receptor 3.
Therapeutics and clinical risk management 2005;1(3):231-41.
2005: Lee Ming Boo; H Helen Lin; Vincent Chung; Bingsen Zhou; Stan Louie; Michael A O'Reilly; Yun Yen; David K Ann
High mobility group A2 potentiates genotoxic stress in part through the modulation of basal and DNA damage-dependent phosphatidylinositol 3-kinase-related protein kinase activation.
Cancer research 2005;65(15):6622-30.
2005: Lijun Zhu; George Somlo; Bingsen Zhou; Jimin Shao; Victoria Bedell; Marilyn L Slovak; Xiyong Liu; Jianhong Luo; Yun Yen
Fibroblast growth factor receptor 3 inhibition by short hairpin RNAs leads to apoptosis in multiple myeloma.
Molecular cancer therapeutics 2005;4(5):787-98.
2005: Jimin Shao; Bingsen Zhou; Lijun Zhu; Angel J Di Bilio; Leila Su; Yate-Ching Yuan; Shijun Ren; Eric J Lien; Jennifer Shih; Yun Yen
Determination of the potency and subunit-selectivity of ribonucleotide reductase inhibitors with a recombinant-holoenzyme-based in vitro assay.
Biochemical pharmacology 2005;69(4):627-34.
2005: Shenxian Qian; George Somlo; Bingsen Zhou; Lijun Zhu; Shu Mi; Xueli Mo; Eric M Cheung; Weihua Qiu; Ren-Jang Lin; John Rossi; Melissa Holtz; Peiguo Chu; Yun Yen
Ribozyme cleavage leads to decreased expression of fibroblast growth factor receptor 3 in human multiple myeloma cells, which is associated with apoptosis and downregulation of vascular endothelial growth factor.
Oligonucleotides 2005;15(1):1-11.
2004: Weihua Qiu; Bingsen Zhou; Hongzhi Zou; Xiyong Liu; Peiguo G Chu; Richard Lopez; Jennifer Shih; Christopher Chung; Yun Yen
Hypermethylation of growth arrest DNA damage-inducible gene 45 beta promoter in human hepatocellular carcinoma.
The American journal of pathology 2004;165(5):1689-99.
2004: Xiyong Liu; Bingsen Zhou; Lijun Xue; Weihua Qiu; Jennifer Shih; Shu Zheng; Yun Yen
Nuclear factor Y regulation and promoter transactivation of human ribonucleotide reductase subunit M2 gene in a Gemcitabine resistant KB clone.
Biochemical pharmacology 2004;67(8):1499-511.
2004: Jimin Shao; Bingsen Zhou; Lijun Zhu; Weihua Qiu; Yate-Ching Yuan; Bixin Xi; Yun Yen
In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase.
Cancer research 2004;64(1):1-6.
2003: Bingsen Zhou; Xiyong Liu; Xueli Mo; Lijun Xue; Dana Darwish; Weihua Qiu; Jennifer Shih; Edward B Hwu; Frank Luh; Yun Yen
The human ribonucleotide reductase subunit hRRM2 complements p53R2 in response to UV-induced DNA repair in cells with mutant p53.
Cancer research 2003;63(20):6583-94.
2003: Weihua Qiu; Donald David; Bingsen Zhou; Peiguo G Chu; Bohe Zhang; Mengchao Wu; Jiacheng Xiao; Tianquan Han; Zhenggang Zhu; Tianxiang Wang; Xiyong Liu; Richard Lopez; Paul Frankel; Ambrose Y Jong; Yun Yen
Down-regulation of growth arrest DNA damage-inducible gene 45beta expression is associated with human hepatocellular carcinoma.
The American journal of pathology 2003;162(6):1961-74.
2003: Lijun Xue; Bingsen Zhou; Xiyong Liu; Weihua Qiu; Zhongchu Jin; Yun Yen
Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits.
Cancer research 2003;63(5):980-6.
2002: Bingsen Zhou; Shu Mi; Xueli Mo; Jennifer Shih; Jeffery Tsai; Edward Hu; Margaret Hsu; Kristie Kay; Yun Yen
Time and sequence dependence of hydroxyurea in combination with gemcitabine in human KB cells.
Anticancer research 2002;22(3):1369-77.
2001: Shijun Ren; Zoltan A Tokes; C Csipke; Bingsen Zhou; Yun Yen; Eric J Lien
Inhibition of tumor cell growth by Schiff bases of hydroxysemicarbazide.
Anticancer research 2001;21(5):3445-51.
2001: Bingsen Zhou; Yun Yen
Characterization of the human ribonucleotide reductase M2 subunit gene; genomic structure and promoter analyses.
Cytogenetics and cell genetics 2001;95(1-2):52-9.
2001: Bingsen Zhou; Xueli Mo; Xiyong Liu; Weihua Qiu; Yun Yen
Human ribonucleotide reductase M2 subunit gene amplification and transcriptional regulation in a homogeneous staining chromosome region responsible for the mechanism of drug resistance.
Cytogenetics and cell genetics 2001;95(1-2):34-42.
1999: Yih-Gang Goan; Bingsen Zhou; E Hu; Shu Mi; Yun Yen
Overexpression of ribonucleotide reductase as a mechanism of resistance to 2,2-difluorodeoxycytidine in the human KB cancer cell line.
Cancer research 1999;59(17):4204-7.
1998: Ambrose Y Jong; K Yu; Bingsen Zhou; Tomas Frgala; Charles Patrick Reynolds; Yun Yen
A simple and sensitive ribonucleotide reductase assay.
Journal of biomedical science 1998;5(1):62-8.