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Charles Brown

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Que Dang; Robert M Goeken; Jason M Brenchley; Charles R Brown; Alicia Buckler-White; Ranjini Iyengar; Bernard A P Lafont; Kenta Matsuda; Ronald Plishka; Matthew F Starost; Sonya Whitted; Vanessa M Hirsch
Development of neurological disease is associated with increased immune activation in simian immunodeficiency virus-infected macaques.
Fan Wu; Scott T Aoki; Charles R Brown; Alicia Buckler-White; Robert M Goeken; Ranjini Iyengar; Takeo Kuwata; Ilnour Ourmanov; Ronald Plishka; Vanessa M Hirsch
Sequential evolution and escape from neutralization of simian immunodeficiency virus SIVsmE660 clones in rhesus macaques.
Eri Miyagi; Charles R Brown; Sandrine Opi; Mohammad Khan; Ritu Goila-Gaur; Sandra Kao; Robert C Walker; Vanessa Hirsch; Klaus Strebel
Stably expressed APOBEC3F has negligible antiviral activity.

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All Publications

2012: Que Dang; Robert M Goeken; Jason M Brenchley; Charles R Brown; Alicia Buckler-White; Ranjini Iyengar; Bernard A P Lafont; Kenta Matsuda; Ronald Plishka; Matthew F Starost; Sonya Whitted; Vanessa M Hirsch
Development of neurological disease is associated with increased immune activation in simian immunodeficiency virus-infected macaques.
Journal of virology 2012;86(24):13795-9.
2012: Fan Wu; Scott T Aoki; Charles R Brown; Alicia Buckler-White; Robert M Goeken; Ranjini Iyengar; Takeo Kuwata; Ilnour Ourmanov; Ronald Plishka; Vanessa M Hirsch
Sequential evolution and escape from neutralization of simian immunodeficiency virus SIVsmE660 clones in rhesus macaques.
Journal of virology 2012;86(16):8835-47.
2010: Eri Miyagi; Charles R Brown; Sandrine Opi; Mohammad Khan; Ritu Goila-Gaur; Sandra Kao; Robert C Walker; Vanessa Hirsch; Klaus Strebel
Stably expressed APOBEC3F has negligible antiviral activity.
Journal of virology 2010;84(21):11067-75.
2010: Yanfang Zheng; Ilnour Ourmanov; Robert M Goeken; Sonya Whitted; Charles R Brown; Alicia Buckler-White; Ranjini Iyengar; Ronald Plishka; Vanessa M Hirsch
Correction of a carboxyl terminal simian immunodeficiency virus Nef frameshift mutation restores virus replication in macaques.
Virology 2010;401(2):207-14.
2009: Takeo Kuwata; Yoshiaki Nishimura; Sonya Whitted; Ilnour Ourmanov; Charles R Brown; Que Dang; Alicia Buckler-White; Ranjini Iyengar; Jason M Brenchley; Vanessa M Hirsch
Association of progressive CD4(+) T cell decline in SIV infection with the induction of autoreactive antibodies.
PLoS pathogens 2009;5(4):e1000372.
2008: Que Dang; Robert M Goeken; Charles R Brown; Ronald Plishka; Alicia Buckler-White; Russ Byrum; Brian Foley; Vanessa M Hirsch
Adaptive evolution of simian immunodeficiency viruses isolated from 2 conventional-progressor macaques with encephalitis.
The Journal of infectious diseases 2008;197(12):1695-700.
2007: Charles R Brown; Meggan Czapiga; Juraj Kabat; Que Dang; Ilnour Ourmanov; Yoshiaki Nishimura; Malcolm Martin; Vanessa M Hirsch
Unique pathology in simian immunodeficiency virus-infected rapid progressor macaques is consistent with a pathogenesis distinct from that of classical AIDS.
Journal of virology 2007;81(11):5594-606.
2006: Simoy Goldstein; Charles R Brown; Ilnour Ourmanov; Ivona Pandrea; Alicia Buckler-White; Christopher Erb; Jayashree S. Nandi; Gabriel J Foster; Patrick Autissier; Joern schmitz; Vanessa M Hirsch
Comparison of simian immunodeficiency virus SIVagmVer replication and CD4+ T-cell dynamics in vervet and sabaeus African green monkeys.
Journal of virology 2006;80(10):4868-77.
2006: Takeo Kuwata; Houman Dehghani; Charles R Brown; Ronald Plishka; Alicia Buckler-White; Tatsuhiko Igarashi; Joseph J Mattapallil; Mario Roederer; Vanessa M Hirsch
Infectious molecular clones from a simian immunodeficiency virus-infected rapid-progressor (RP) macaque: evidence of differential selection of RP-specific envelope mutations in vitro and in vivo.
Journal of virology 2006;80(3):1463-75.
2005: Brigitte E Beer; Charles R Brown; Sonya Whitted; Simoy Goldstein; Robert M Goeken; Ronald Plishka; Alicia Buckler-White; Vanessa M Hirsch
Immunodeficiency in the absence of high viral load in pig-tailed macaques infected with Simian immunodeficiency virus SIVsun or SIVlhoest.
Journal of virology 2005;79(22):14044-56.
2005: Yoshiaki Nishimura; Charles R Brown; Joseph J Mattapallil; Tatsuhiko Igarashi; Alicia Buckler-White; Bernard A P Lafont; Vanessa M Hirsch; Mario Roederer; Malcolm Martin
Resting naive CD4+ T cells are massively infected and eliminated by X4-tropic simian-human immunodeficiency viruses in macaques.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(22):8000-5.
2005: Simoy Goldstein; Ilnour Ourmanov; Charles R Brown; Ronald Plishka; Alicia Buckler-White; Russ Byrum; Vanessa M Hirsch
Plateau levels of viremia correlate with the degree of CD4+-T-cell loss in simian immunodeficiency virus SIVagm-infected pigtailed macaques: variable pathogenicity of natural SIVagm isolates.
Journal of virology 2005;79(8):5153-62.
2004: Vanessa M Hirsch; Sampa Santra; Simoy Goldstein; Ronald Plishka; Alicia Buckler-White; Aruna Seth; Ilnour Ourmanov; Charles R Brown; Ronald Engle; David Montefiori; Jennifer Glowczwskie; Kevin Kunstman; Steven Wolinsky; Norman L Letvin
Immune failure in the absence of profound CD4+ T-lymphocyte depletion in simian immunodeficiency virus-infected rapid progressor macaques.
Journal of virology 2004;78(1):275-84.
2002: Houman Dehghani; Charles R Brown; Ronald Plishka; Alicia Buckler-White; Vanessa M Hirsch
The ITAM in Nef influences acute pathogenesis of AIDS-inducing simian immunodeficiency viruses SIVsm and SIVagm without altering kinetics or extent of viremia.
Journal of virology 2002;76(9):4379-89.
2002: Tatsuhiko Igarashi; Charles R Brown; Russ Byrum; Yoshiaki Nishimura; Yasuyuki Endo; Ronald Plishka; Charles Buckler; Alicia Buckler-White; Georgina Miller; Vanessa M Hirsch; Malcolm Martin
Rapid and irreversible CD4+ T-cell depletion induced by the highly pathogenic simian/human immunodeficiency virus SHIV(DH12R) is systemic and synchronous.
Journal of virology 2002;76(1):379-91.
2001: Brigitte E Beer; Brian Foley; Carla Kuiken; Zena Tooze; Robert M Goeken; Charles R Brown; J Hu; M St Claire; Bette T Korber; Vanessa M Hirsch
Characterization of novel simian immunodeficiency viruses from red-capped mangabeys from Nigeria (SIVrcmNG409 and -NG411).
Journal of virology 2001;75(24):12014-27.
2001: M Haddrick; Charles R Brown; Ronald Plishka; Alicia Buckler-White; Vanessa M Hirsch; H Ginsberg
Biologic studies of chimeras of highly and moderately virulent molecular clones of simian immunodeficiency virus SIVsmPBj suggest a critical role for envelope in acute AIDS virus pathogenesis.
Journal of virology 2001;75(14):6645-59.
2001: Tatsuhiko Igarashi; Charles R Brown; Yasuyuki Endo; Alicia Buckler-White; Ronald Plishka; N Bischofberger; Vanessa M Hirsch; Malcolm Martin
Macrophage are the principal reservoir and sustain high virus loads in rhesus macaques after the depletion of CD4+ T cells by a highly pathogenic simian immunodeficiency virus/HIV type 1 chimera (SHIV): Implications for HIV-1 infections of humans.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(2):658-63.
2000: Simoy Goldstein; Ilnour Ourmanov; Charles R Brown; Brigitte E Beer; WR Elkins; Ronald Plishka; Alicia Buckler-White; Vanessa M Hirsch
Wide range of viral load in healthy african green monkeys naturally infected with simian immunodeficiency virus.
Journal of virology 2000;74(24):11744-53.
2000: Simoy Goldstein; Charles R Brown; Houman Dehghani; Jeffrey D Lifson; Vanessa M Hirsch
Intrinsic susceptibility of rhesus macaque peripheral CD4(+) T cells to simian immunodeficiency virus in vitro is predictive of in vivo viral replication.
Journal of virology 2000;74(20):9388-95.
2000: Ilnour Ourmanov; Charles R Brown; Bernard Moss; M Carroll; Linda S Wyatt; L Pletneva; Simoy Goldstein; D Venzon; Vanessa M Hirsch
Comparative efficacy of recombinant modified vaccinia virus Ankara expressing simian immunodeficiency virus (SIV) Gag-Pol and/or Env in macaques challenged with pathogenic SIV.
Journal of virology 2000;74(6):2740-51.
1998: Vanessa M Hirsch; Mark E Sharkey; Charles R Brown; B Brichacek; Simoy Goldstein; J Wakefield; Russ Byrum; WR Elkins; B H Hahn; Jeffrey D Lifson; Mario Stevenson
Vpx is required for dissemination and pathogenesis of SIV(SM) PBj: evidence of macrophage-dependent viral amplification.
Nature medicine 1998;4(12):1401-8.
1998: Vanessa M Hirsch; G Dapolito; A Hahn; Jeffrey D Lifson; David Montefiori; Charles R Brown; Robert M Goeken
Viral genetic evolution in macaques infected with molecularly cloned simian immunodeficiency virus correlates with the extent of persistent viremia.
Journal of virology 1998;72(8):6482-9.
1998: Brigitte E Beer; Joachim Denner; Charles R Brown; Stephen Norley; Jan zur Megede; Cheick Coulibaly; Roland Plesker; Silke Holzammer; M Baier; Vanessa M Hirsch; Reinhard Kurth
Simian immunodeficiency virus of African green monkeys is apathogenic in the newborn natural host.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1998;18(3):210-20.