Tong Zhou

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Lymphocyte Activation

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Frederick Peter J; Kendrick James E; Straughn J Michael; Della Manna Debbie L; Oliver Patsy G; Lin Hui-Yi; Grizzle William E; Stockard Cecil R; Alvarez Ronald D; Zhou Tong; LoBuglio Albert F; Buchsbaum Donald J
Effect of TRA-8 anti-death receptor 5 antibody in combination with chemotherapy in an ex vivo human ovarian cancer model.
Sun M; Song L; Li Y; Zhou T; Jope R S
Identification of an antiapoptotic protein complex at death receptors.
Li Xinrui; Su Kaihong; Ji Chuanyi; Szalai Alexander J; Wu Jianming; Zhang Yan; Zhou Tong; Kimberly Robert P; Edberg Jeffrey C
Immune opsonins modulate BLyS/BAFF release in a receptor-specific fashion.

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2009: Frederick Peter J; Kendrick James E; Straughn J Michael; Della Manna Debbie L; Oliver Patsy G; Lin Hui-Yi; Grizzle William E; Stockard Cecil R; Alvarez Ronald D; Zhou Tong; LoBuglio Albert F; Buchsbaum Donald J
Effect of TRA-8 anti-death receptor 5 antibody in combination with chemotherapy in an ex vivo human ovarian cancer model.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2009;19(5):814-9.
2008: Sun M; Song L; Li Y; Zhou T; Jope R S
Identification of an antiapoptotic protein complex at death receptors.
Cell death and differentiation 2008;15(12):1887-900.
2008: Li Xinrui; Su Kaihong; Ji Chuanyi; Szalai Alexander J; Wu Jianming; Zhang Yan; Zhou Tong; Kimberly Robert P; Edberg Jeffrey C
Immune opsonins modulate BLyS/BAFF release in a receptor-specific fashion.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(2):1012-8.
2008: Fiveash John B; Gillespie G Yancey; Oliver Patsy G; Zhou Tong; Belenky Michael L; Buchsbaum Donald J
Enhancement of glioma radiotherapy and chemotherapy response with targeted antibody therapy against death receptor 5.
International journal of radiation oncology, biology, physics 2008;71(2):507-16.
2008: Oliver Patsy G; LoBuglio Albert F; Zinn Kurt R; Kim Hyunki; Nan Li; Zhou Tong; Wang Wenquan; Buchsbaum Donald J
Treatment of human colon cancer xenografts with TRA-8 anti-death receptor 5 antibody alone or in combination with CPT-11.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(7):2180-9.
2007: Derosier Leo Christopher; Vickers Selwyn M; Zinn Kurt R; Huang Zhi; Wang Wenquan; Grizzle William E; Sellers Jeffrey; Stockard Cecil R; Zhou Tong; Oliver Patsy G; Arnoletti Pablo; Lobuglio Albert F; Buchsbaum Donald J
TRA-8 anti-DR5 monoclonal antibody and gemcitabine induce apoptosis and inhibit radiologically validated orthotopic pancreatic tumor growth.
Molecular cancer therapeutics 2007;6(12 Pt 1):3198-207.
2007: DeRosier Leo Christopher; Buchsbaum Donald J; Oliver Patsy G; Huang Zhi-Qiang; Sellers Jeffrey C; Grizzle William E; Wang Wenquan; Zhou Tong; Zinn Kurt R; Long Joshua W; Vickers Selwyn M
Combination treatment with TRA-8 anti death receptor 5 antibody and CPT-11 induces tumor regression in an orthotopic model of pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(18 Pt 2):5535s-5543s.
2007: Estes Jacob M; Oliver Patsy G; Straughn J Michael; Zhou Tong; Wang Wenquan; Grizzle William E; Alvarez Ronald D; Stockard Cecil R; LoBuglio Albert F; Buchsbaum Donald J
Efficacy of anti-death receptor 5 (DR5) antibody (TRA-8) against primary human ovarian carcinoma using a novel ex vivo tissue slice model.
Gynecologic oncology 2007;105(2):291-8.
2007: Su Kaihong; Yang Hengxuan; Li Xinrui; Li Xiaoli; Gibson Andrew W; Cafardi John M; Zhou Tong; Edberg Jeffrey C; Kimberly Robert P
Expression profile of FcgammaRIIb on leukocytes and its dysregulation in systemic lupus erythematosus.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):3272-80.
2006: Li Yang; Wang Hong; Wang Zheng; Makhija Sharmila; Buchsbaum Donald; LoBuglio Albert; Kimberly Robert; Zhou Tong
Inducible resistance of tumor cells to tumor necrosis factor-related apoptosis-inducing ligand receptor 2-mediated apoptosis by generation of a blockade at the death domain function.
Cancer research 2006;66(17):8520-8.
2006: Buchsbaum Donald J; Zhou Tong; Lobuglio Albert F
TRAIL receptor-targeted therapy.
Future oncology (London, England) 2006;2(4):493-508.
2006: Straughn J Michael; Oliver Patsy G; Zhou Tong; Wang Wenquan; Alvarez Ronald D; Grizzle William E; Buchsbaum Donald J
Anti-tumor activity of TRA-8 anti-death receptor 5 (DR5) monoclonal antibody in combination with chemotherapy and radiation therapy in a cervical cancer model.
Gynecologic oncology 2006;101(1):46-54.
2006: Kaliberov S A; Chiz S; Kaliberova L N; Krendelchtchikova V; Della Manna D; Zhou T; Buchsbaum D J
Combination of cytosine deaminase suicide gene expression with DR5 antibody treatment increases cancer cell cytotoxicity.
Cancer gene therapy 2006;13(2):203-14.
2006: Hsu Hui-Chen; Zhou Tong; Kim Helen; Barnes Stephen; Yang PingAr; Wu Qi; Zhou Juling; Freeman Bruce A; Luo Ming; Mountz John D
Production of a novel class of polyreactive pathogenic autoantibodies in BXD2 mice causes glomerulonephritis and arthritis.
Arthritis and rheumatism 2006;54(1):343-55.
2005: Carter Robert H; Zhao Hong; Liu Ximeng; Pelletier Marc; Chatham Winn; Kimberly Robert; Zhou Tong
Expression and occupancy of BAFF-R on B cells in systemic lupus erythematosus.
Arthritis and rheumatism 2005;52(12):3943-54.
2004: Hsu Hui-Chen; Zhou Tong; Mountz John D
Nur77 family of nuclear hormone receptors.
Current drug targets. Inflammation and allergy 2004;3(4):413-23.
2004: Zhou Tong; Wang Hong; Luo Danlin; Rowe Thomas; Wang Zheng; Hogan Robert J; Qiu Shihong; Bunzel Robert J; Huang Guoqiang; Mishra Vinod; Voss Thomas G; Kimberly Robert; Luo Ming
An exposed domain in the severe acute respiratory syndrome coronavirus spike protein induces neutralizing antibodies.
Journal of virology 2004;78(13):7217-26.
2004: Liu Weimin; Szalai Alex; Zhao Limin; Liu Di; Martin Flavius; Kimberly Robert P; Zhou Tong; Carter Robert H
Control of spontaneous B lymphocyte autoimmunity with adenovirus-encoded soluble TACI.
Arthritis and rheumatism 2004;50(6):1884-96.
2004: Song Ling; Zhou Tong; Jope Richard S
Lithium facilitates apoptotic signaling induced by activation of the Fas death domain-containing receptor.
BMC neuroscience 2004;5():20.
2004: Kaliberov S; Stackhouse M A; Kaliberova L; Zhou T; Buchsbaum D J
Enhanced apoptosis following treatment with TRA-8 anti-human DR5 monoclonal antibody and overexpression of exogenous Bax in human glioma cells.
Gene therapy 2004;11(8):658-67.
2003: Buchsbaum Donald J; Zhou Tong; Grizzle William E; Oliver Patsy G; Hammond Charlotte J; Zhang Sijian; Carpenter Mark; LoBuglio Albert F
Antitumor efficacy of TRA-8 anti-DR5 monoclonal antibody alone or in combination with chemotherapy and/or radiation therapy in a human breast cancer model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(10 Pt 1):3731-41.
2003: Xu Yuanyuan; Szalai Alexander J; Zhou Tong; Zinn Kurt R; Chaudhuri Tandra R; Li Xiaoli; Koopman William J; Kimberly Robert P
Fc gamma Rs modulate cytotoxicity of anti-Fas antibodies: implications for agonistic antibody-based therapeutics.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(2):562-8.
2003: Zhou Tong; Zhang Jun; Carter Robert; Kimberly Robert
BLyS and B cell autoimmunity.
Current directions in autoimmunity 2003;6():21-37.
2002: Matsuki Y; Zhang H G; Hsu H C; Yang P A; Zhou T; Dodd C H; Cecconi F; Gruss P; Tadakuma T; Mountz J D
Different role of Apaf-1 in positive selection, negative selection and death by neglect in foetal thymic organ culture.
Scandinavian journal of immunology 2002;56(2):174-84.
2002: Choi Chulhee; Kutsch Olaf; Park Jinseu; Zhou Tong; Seol Dai-Wu; Benveniste Etty N
Tumor necrosis factor-related apoptosis-inducing ligand induces caspase-dependent interleukin-8 expression and apoptosis in human astroglioma cells.
Molecular and cellular biology 2002;22(3):724-36.
2002: Zhou Tong; Mountz John D; Kimberly Robert P
Immunobiology of tumor necrosis factor receptor superfamily.
Immunologic research 2002;26(1-3):323-36.
2002: Zhan Huang-Ge; Mountz John D; Fleck Martin; Zhou Tong; Hsu Hui-Chen
Specific deletion of autoreactive T cells by adenovirus-transfected, Fas ligand-producing antigen-presenting cells.
Immunologic research 2002;26(1-3):235-46.
2001: Hsu H C; Zhang H G; Song G G; Xie J; Liu D; Yang P A; Fleck M; Wintersberger W; Zhou T; Edwards C K; Mountz J D
Defective Fas ligand-mediated apoptosis predisposes to development of a chronic erosive arthritis subsequent to Mycoplasma pulmonis infection.
Arthritis and rheumatism 2001;44(9):2146-59.
2001: Hsu H C; Zhou T; Shi J; Yang P A; Liu D; Zhang H G; Bluethmann H; Mountz J D
Aged mice exhibit in vivo defective peripheral clonal deletion of D(b)/H-Y reactive CD8(+) T cells.
Mechanisms of ageing and development 2001;122(3):305-26.
2001: Hsu H C; Matsuki Y; Zhang H G; Zhou T; Mountz J D
The Fas signaling connection between autoimmunity and embryonic lethality.
Journal of clinical immunology 2001;21(1):1-14.
2000: Zhang H G; Xie J; Yang P; Wang Y; Xu L; Liu D; Hsu H C; Zhou T; Edwards C K; Mountz J D
Adeno-associated virus production of soluble tumor necrosis factor receptor neutralizes tumor necrosis factor alpha and reduces arthritis.
Human gene therapy 2000;11(17):2431-42.
2000: Zhang H G; Huang N; Liu D; Bilbao L; Zhang X; Yang P; Zhou T; Curiel D T; Mountz J D
Gene therapy that inhibits nuclear translocation of nuclear factor kappaB results in tumor necrosis factor alpha-induced apoptosis of human synovial fibroblasts.
Arthritis and rheumatism 2000;43(5):1094-105.
2000: Lee S J; Zhou T; Choi C; Wang Z; Benveniste E N
Differential regulation and function of Fas expression on glial cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(3):1277-85.
1999: Bilbao G; Zhang H; Contreras J L; Zhou T; Feng M; Saito I; Mountz J D; Curiel D T
Construction of a recombinant adenovirus vector encoding Fas ligand with a CRE/Loxp inducible system.
Transplantation proceedings 1999;31(1-2):792-3.
1999: Zhang H G; Su X; Liu D; Liu W; Yang P; Wang Z; Edwards C K; Bluethmann H; Mountz J D; Zhou T
Induction of specific T cell tolerance by Fas ligand-expressing antigen-presenting cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1423-30.
1999: Zhou T; Song L; Yang P; Wang Z; Lui D; Jope R S
Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases.
Nature medicine 1999;5(1):42-8.
1999: Hsu H C; Mountz J D; Zhou T
Regulation of Fas-mediated apoptosis in CD2-fas transgenic mice.
International reviews of immunology 1999;18(4):309-27.
1998: Zhang H G; Liu D; Heike Y; Yang P; Wang Z; Wang X; Curiel D T; Zhou T; Mountz J D
Induction of specific T-cell tolerance by adenovirus-transfected, Fas ligand-producing antigen presenting cells.
Nature biotechnology 1998;16(11):1045-9.
1998: Zhang H G; Zhou T; Yang P; Edwards C K; Curiel D T; Mountz J D
Inhibition of tumor necrosis factor alpha decreases inflammation and prolongs adenovirus gene expression in lung and liver.
Human gene therapy 1998;9(13):1875-84.
1998: Su X; Cheng J; Liu W; Liu C; Wang Z; Yang P; Zhou T; Mountz J D
Autocrine and paracrine apoptosis are mediated by differential regulation of Fas ligand activity in two distinct Jurkat T cell populations.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(11):5288-93.
1998: Zhang H G; Bilbao G; Zhou T; Contreras J L; Gómez-Navarro J; Feng M; Saito I; Mountz J D; Curiel D T
Application of a Fas ligand encoding a recombinant adenovirus vector for prolongation of transgene expression.
Journal of virology 1998;72(3):2483-90.
1998: Su X; Zhou T; Yang P; Edwards C K; Mountz J D
Reduction of arthritis and pneumonitis in motheaten mice by soluble tumor necrosis factor receptor.
Arthritis and rheumatism 1998;41(1):139-49.
1997: Mountz J D; Wu J; Zhou T; Hsu H C
Cell death and longevity: implications of Fas-mediated apoptosis in T-cell senescence.
Immunological reviews 1997;160():19-30.
1997: Cheng J; Liu C; Yang P; Zhou T; Mountz J D
Increased lymphocyte apoptosis in Fas ligand transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(2):674-84.
1997: Hsu H C; Zhou T; Yang P A; Herrera G A; Mountz J D
Increased acute-phase response and renal amyloidosis in aged CD2-fas-transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(12):5988-96.
1997: Zhou T; Fleck M; Müeller-Ladner U; Yang P; Wang Z; Gay S; Matsumoto S; Mountz J D
Kinetics of Fas-induced apoptosis in thymic organ culture.
Journal of clinical immunology 1997;17(1):74-84.
1996: Mountz J D; Zhou T; Su X; Cheng J; Pierson M; Bluethmann H; Edwards C K
Autoimmune disease results from multiple interactive defects in apoptosis induction molecules and signaling pathways.
Behring Institute Mitteilungen 1996;(97):200-19.
1996: Edwards C K; Zhou T; Zhang J; Baker T J; De M; Long R E; Borcherding D R; Bowlin T L; Bluethmann H; Mountz J D
Inhibition of superantigen-induced proinflammatory cytokine production and inflammatory arthritis in MRL-lpr/lpr mice by a transcriptional inhibitor of TNF-alpha.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(4):1758-72.
1996: Su X; Zhou T; Yang P A; Wang Z; Mountz J D
Hematopoietic cell protein-tyrosine phosphatase-deficient motheaten mice exhibit T cell apoptosis defect.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(11):4198-208.
1996: Zhou T; Cheng J; Yang P; Wang Z; Liu C; Su X; Bluethmann H; Mountz J D
Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells.
The Journal of experimental medicine 1996;183(4):1879-92.
1996: Zhou T; Edwards C K; Yang P; Wang Z; Bluethmann H; Mountz J D
Greatly accelerated lymphadenopathy and autoimmune disease in lpr mice lacking tumor necrosis factor receptor I.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(8):2661-5.
1996: Mountz J D; Edwards C K; Cheng J; Yang P; Wang Z; Liu C; Su X; Bluethmann H; Zhou T
Autoimmunity due to defective Nur77, Fas, and TNF-RI apoptosis.
Advances in experimental medicine and biology 1996;406():241-62.
1995: Mountz J D; Baker T J; Borcherding D R; Bluethmann H; Zhou T; Edwards C K
Increased susceptibility of fas mutant MRL-lpr/lpr mice to staphylococcal enterotoxin B-induced septic shock.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(10):4829-37.
1995: Mountz J D; Zhou T; Wu J; Wang W; Su X; Cheng J
Regulation of apoptosis in immune cells.
Journal of clinical immunology 1995;15(1):1-16.
1995: Mountz J D; Cheng J; Su X; Wu J; Zhou T
Autoimmunity, apoptosis defects and retroviruses.
Advances in experimental medicine and biology 1995;374():183-201.
1994: Mountz J D; Wu J; Cheng J; Zhou T
Autoimmune disease. A problem of defective apoptosis.
Arthritis and rheumatism 1994;37(10):1415-20.
1994: Wu J; Zhou T; Zhang J; He J; Gause W C; Mountz J D
Correction of accelerated autoimmune disease by early replacement of the mutated lpr gene with the normal Fas apoptosis gene in the T cells of transgenic MRL-lpr/lpr mice.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(6):2344-8.
1994: Mountz J D; Bluethmann H; Zhou T; Wu J
Defective clonal deletion and anergy induction in TCR transgenic lpr/lpr mice.
Seminars in immunology 1994;6(1):27-37.
1994: Mountz J D; Zhou T; Long R E; Bluethmann H; Koopman W J; Edwards C K
T cell influence on superantigen-induced arthritis in MRL-lpr/lpr mice.
Arthritis and rheumatism 1994;37(1):113-24.
1994: Mountz J D; Zhou T; Bluethmann H; Wu J; Edwards C K
Apoptosis defects analyzed in TcR transgenic and fas transgenic lpr mice.
International reviews of immunology 1994;11(4):321-42.
1993: Zhou T; Bluethmann H; Eldridge J; Berry K; Mountz J D
Origin of CD4-CD8-B220+ T cells in MRL-lpr/lpr mice. Clues from a T cell receptor beta transgenic mouse.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(8 Pt 1):3651-67.
1992: Zhou T; Bluethmann H; Zhang J; Edwards C K; Mountz J D
Defective maintenance of T cell tolerance to a superantigen in MRL-lpr/lpr mice.
The Journal of experimental medicine 1992;176(4):1063-72.
1991: Zhou T; Bluethmann H; Eldridge J; Brockhaus M; Berry K; Mountz J D
Abnormal thymocyte development and production of autoreactive T cells in T cell receptor transgenic autoimmune mice.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(2):466-74.
1990: Mountz J D; Zhou T; Eldridge J; Berry K; Blüthmann H
Transgenic rearranged T cell receptor gene inhibits lymphadenopathy and accumulation of CD4-CD8-B220+ T cells in lpr/lpr mice.
The Journal of experimental medicine 1990;172(6):1805-17.

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