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Eric Brown

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Gregory F Wu; Matthew J Riese; Michelle Schmidt; Jennifer E Smith-Garvin; Eric J Brown; Evann Corbo; Martha S Jordan; Tom Li Stephen; Jonathan S Maltzman
Conditional deletion of SLP-76 in mature T cells abrogates peripheral immune responses.
Jennifer L Onksen; Eric J Brown; Julie A Blendy
Selective deletion of a cell cycle checkpoint kinase (ATR) reduces neurogenesis and alters responses in rodent models of behavioral affect.
Oren Gilad; Barzin Y Nabet; Ryan L Ragland; David W Schoppy; Kevin D Smith; Amy C Durham; Eric J Brown
Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner.

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All Publications

2011: Gregory F Wu; Matthew J Riese; Michelle Schmidt; Jennifer E Smith-Garvin; Eric J Brown; Evann Corbo; Martha S Jordan; Tom Li Stephen; Jonathan S Maltzman
Conditional deletion of SLP-76 in mature T cells abrogates peripheral immune responses.
European journal of immunology 2011;41(7):2064-73.
2011: Jennifer L Onksen; Eric J Brown; Julie A Blendy
Selective deletion of a cell cycle checkpoint kinase (ATR) reduces neurogenesis and alters responses in rodent models of behavioral affect.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2011;36(5):960-9.
2010: Oren Gilad; Barzin Y Nabet; Ryan L Ragland; David W Schoppy; Kevin D Smith; Amy C Durham; Eric J Brown
Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner.
Cancer research 2010;70(23):9693-702.
2010: David W Schoppy; Yaroslava Ruzankina; Eric J Brown
Removing all obstacles: a critical role for p53 in promoting tissue renewal.
Cell cycle (Georgetown, Tex.) 2010;9(7):1313-9.
2009: Kevin D Smith; Michael A Fu; Eric J Brown
Tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis.
The Journal of cell biology 2009;187(1):15-23.
2009: Yaroslava Ruzankina; David W Schoppy; Amma Asare; Carolyn E Clark; Robert H Vonderheide; Eric J Brown
Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53.
Nature genetics 2009;41(10):1144-9.
2009: Jessica A Bertout; Amar J Majmundar; John D Gordan; Jennifer C Lam; Dara Ditsworth; Brian Keith; Eric J Brown; Katherine L Nathanson; M Celeste Simon
HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(34):14391-6.
2009: Karen A Urtishak; Kevin D Smith; Rebecca A Chanoux; Roger A. Greenberg; F Brad Johnson; Eric J Brown
Timeless Maintains Genomic Stability and Suppresses Sister Chromatid Exchange during Unperturbed DNA Replication.
The Journal of biological chemistry 2009;284(13):8777-85.
2009: Rebecca A Chanoux; Bu Yin; Karen A Urtishak; Amma Asare; Craig H Bassing; Eric J Brown
ATR and H2AX cooperate in maintaining genome stability under replication stress.
The Journal of biological chemistry 2009;284(9):5994-6003.
2008: Yaroslava Ruzankina; Amma Asare; Eric J Brown
Replicative stress, stem cells and aging.
Mechanisms of ageing and development 2008;129(7-8):460-6.
2007: Yaroslava Ruzankina; Carolina Pinzon-Guzman; Amma Asare; Tony Ong; Laura Pontano; George Cotsarelis; Valerie P Zediak; Marielena Velez; Avinash Bhandoola; Eric J Brown
Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss.
Cell stem cell 2007;1(1):113-26.
2007: Michaela Gruber; Cheng-Jun Hu; Randall S Johnson; Eric J Brown; Brian Keith; M Celeste Simon
Acute postnatal ablation of Hif-2alpha results in anemia.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(7):2301-6.
2006: Ya-Xiong Chen; Jizhou Yan; Karen Keeshan; Anthony T Tubbs; Haoren Wang; Albert Silva; Eric J Brown; Jay L Hess; Warren S Pear; Xianxin Hua
The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(4):1018-23.
2005: Ademi E Santiago-Walker; Aphrothiti J Fikaris; Gary D Kao; Eric J Brown; Marcelo G Kazanietz; Judy L Meinkoth
Protein kinase C delta stimulates apoptosis by initiating G1 phase cell cycle progression and S phase arrest.
The Journal of biological chemistry 2005;280(37):32107-14.
2004: Eric J Brown
Analysis of cell cycle progression and genomic integrity in early lethal knockouts.
Methods in molecular biology (Clifton, N.J.) 2004;280():201-12.
2001: Claire M Steppan; ST Bailey; S Bhat; Eric J Brown; Ronadip Banerjee; C M Wright; Hiralben R Patel; Rexford S Ahima; Mitchell Lazar
The hormone resistin links obesity to diabetes.
Nature 2001;409(6818):307-12.
2001: Claire M Steppan; Eric J Brown; C M Wright; S Bhat; Ronadip Banerjee; Charlotte Y Dai; Greg H Enders; Debra G Silberg; Xiaoming Wen; Gary D Wu; Mitchell Lazar
A family of tissue-specific resistin-like molecules.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(2):502-6.