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Wei-Guo Zhu

Research Profile

Chemicals & Drugs

Phenomena

Physiology

Anatomy

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Lung Neoplasms

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Publications

TOP 3
Ying Zhao; Jingyi Zhou; Wan Fu; Xue Li; Ke Ma; Lina Wang; Fuzheng Wei; Jing Yang; Wei-Guo Zhu
The axis of MAPK1/3-XBP1u-FOXO1 controls autophagic dynamics in cancer cells.
Donglai Wang; Haiying Wang; Lina Wang; Fu-Zheng Wei; Yang Yang; Yu Yu; Hongquan Zhang; Ying Zhao; Jingyi Zhou; Yoshimitsu Akiyama; Yipeng Du; Xiangyu Liu; Danyu Lu; Xiaopeng Lu; Changchun Shen; Boyan Song; Wei-Guo Zhu
Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability.
Ying Zhao; Jingyi Zhou; Mu-Yan Cai; Wan Fu; Xue Li; Ke Ma; Lina Wang; Fu-Zheng Wei; Dan Xie; Jing Yang; Wei-Guo Zhu
XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cells.

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All Publications

2013: Ying Zhao; Jingyi Zhou; Wan Fu; Xue Li; Ke Ma; Lina Wang; Fuzheng Wei; Jing Yang; Wei-Guo Zhu
The axis of MAPK1/3-XBP1u-FOXO1 controls autophagic dynamics in cancer cells.
Autophagy 2013;9(5):794-6.
2013: Donglai Wang; Haiying Wang; Lina Wang; Fu-Zheng Wei; Yang Yang; Yu Yu; Hongquan Zhang; Ying Zhao; Jingyi Zhou; Yoshimitsu Akiyama; Yipeng Du; Xiangyu Liu; Danyu Lu; Xiaopeng Lu; Changchun Shen; Boyan Song; Wei-Guo Zhu
Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(14):5516-21.
2013: Ying Zhao; Jingyi Zhou; Mu-Yan Cai; Wan Fu; Xue Li; Ke Ma; Lina Wang; Fu-Zheng Wei; Dan Xie; Jing Yang; Wei-Guo Zhu
XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cells.
Cell research 2013;23(4):491-507.
2013: Li Li; Cheng Wang; Jin-Yu Wang; Feng-Ying Fu; Hong Lei; Li-Peng Wu; Zhi-Guo Zhang; Wei-Guo Zhu; Li-Ling Wu
Angiotensin II reduces cardiac AdipoR1 expression through AT1 receptor/ROS/ERK1/2/c-Myc pathway.
PloS one 2013;8(1):e49915.
2012: Jingyi Zhou; Xue Li; Wenjuan Liao; Ke Ma; Donglai Wang; Lina Wang; Yachen Wang; Jing Yang; Yuxin Yin; Yu Zhang; Ying Zhao; Wei-Guo Zhu
FOXO3 induces FOXO1-dependent autophagy by activating the AKT1 signaling pathway.
Autophagy 2012;8(12):1712-23.
2012: Yu Yu; Ting Zhao; Wei-Guo Zhu; Weigang Fang; Yuqing Liu; Bo Ma; Yunling Wang; Junzhou Wu; Hongquan Zhang
Kindlin 2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signalling.
EMBO reports 2012;13(8):750-8.
2012: Haiying Wang; Ping Zhang; Zhixing Zheng; Wen Zhou; Qihua He; Bo Tu; Wei-Guo Zhu
The HDAC inhibitor depsipeptide transactivates the p53/p21 pathway by inducing DNA damage.
DNA repair 2012;11(2):146-56.
2012: Bo Gu; Wei-Guo Zhu
Surf the post-translational modification network of p53 regulation.
International journal of biological sciences 2012;8(5):672-84.
2011: Ying Zhao; Yachen Wang; Wei-Guo Zhu
Applications of post-translational modifications of FoxO family proteins in biological functions.
Journal of molecular cell biology 2011;3(5):276-82.
2011: Jing Yang; Ping Zhang; Ying Zhao; Jingyi Zhou; Fen-Jun Jiang; Harm H Kampinga; Wenjuan Liao; Ke Ma; Bo Tu; Lina Wang; Zhiping Xie; Wei-Guo Zhu
Deficiency of hepatocystin induces autophagy through an mTOR-dependent pathway.
Autophagy 2011;7(7):748-59.
2011: Chong Wang; Yachen Wang; Michael A McNutt; Wei-Guo Zhu
Autophagy process is associated with anti-neoplastic function.
Acta biochimica et biophysica Sinica 2011;43(6):425-32.
2011: Bo-Yan Song; Wei-Guo Zhu
[Advances in effector protein of histone methylation].
Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji 2011;33(4):285-92.
2011: Xiangyu Liu; Donglai Wang; Ying Zhao; Bo Tu; Zhixing Zheng; Lina Wang; Haiying Wang; Wei Gu; Robert G Roeder; Wei-Guo Zhu
Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1).
Proceedings of the National Academy of Sciences of the United States of America 2011;108(5):1925-30.
2010: Wen-Jia Yang; Dong-Lai Wang; Wei-Guo Zhu
[Mechanism of regulating deacetylase SIRT1 expression and activity.].
Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji 2010;32(10):1003-8.
2010: Ying Zhao; Lina Wang; Jing Yang; Ping Zhang; Ke Ma; Jingyi Zhou; Wenjuan Liao; Wei-Guo Zhu
Anti-neoplastic activity of the cytosolic FoxO1 results from autophagic cell death.
Autophagy 2010;6(7):988-90.
2010: Ying Zhao; Jing Yang; Wenjuan Liao; Xiangyu Liu; Hui Zhang; Shan Wang; Donglai Wang; Jingnan Feng; Li Yu; Wei-Guo Zhu
Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity.
Nature cell biology 2010;12(7):665-75.
2009: Yu SU; Xi Wang; Wei-Guo Zhu
[DNA methyltransferases: the role in regulation of gene expression and biological processes].
Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji 2009;31(11):1087-93.
2009: Wenjuan Liao; Michael A McNutt; Wei-Guo Zhu
The comet assay: a sensitive method for detecting DNA damage in individual cells.
Methods (San Diego, Calif.) 2009;48(1):46-53.
2009: Yang Yang; Ying Zhao; Wenjuan Liao; Jing Yang; Lipeng Wu; Zhixing Zheng; Yu Yu; Wen Zhou; Lian Li; Jingnan Feng; Haiying Wang; Wei-Guo Zhu
Acetylation of FoxO1 activates Bim expression to induce apoptosis in response to histone deacetylase inhibitor depsipeptide treatment.
Neoplasia (New York, N.Y.) 2009;11(4):313-24.
2009: Wen Zhou; Wei-Guo Zhu
The changing face of HDAC inhibitor depsipeptide.
Current cancer drug targets 2009;9(1):91-100.
2008: Xi Wang; Wei-Guo Zhu
[Advances in histone methyltransferases and histone demethylases].
Ai zheng = Aizheng = Chinese journal of cancer 2008;27(10):1018-25.
2008: Li-Peng Wu; Xi Wang; Lian Li; Ying Zhao; Shaoli Lu; Yu Yu; Wen Zhou; Xiangyu Liu; Jing Yang; Zhixin Zheng; Hui Zhang; Jingnan Feng; Yang Yang; Haiying Wang; Wei-Guo Zhu
Histone deacetylase inhibitor depsipeptide activates silenced genes through decreasing both CpG and H3K9 methylation on the promoter.
Molecular and cellular biology 2008;28(10):3219-35.
2008: Haiying Wang; Ying Zhao; Lian Li; Michael A McNutt; Lipeng Wu; Shaoli Lu; Yu Yu; Wen Zhou; Jingnan Feng; Guolin Chai; Yang Yang; Wei-Guo Zhu
An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-aza-2'-deoxycytidine treatment.
The Journal of biological chemistry 2008;283(5):2564-74.
2008: Guolin Chai; Lian Li; Wen Zhou; Lipeng Wu; Ying Zhao; Donglai Wang; Shaoli Lu; Yu Yu; Haiying Wang; Michael A McNutt; Ye-Guang Hu; Yingqi Chen; Yang Yang; Xin Wu; Gregory A Otterson; Wei-Guo Zhu
HDAC inhibitors act with 5-aza-2'-deoxycytidine to inhibit cell proliferation by suppressing removal of incorporated abases in lung cancer cells.
PloS one 2008;3(6):e2445.
2007: Yang Yang; Takayuki Ikezoe; Zhixing Zheng; Hirokuni Taguchi; H Phillip Koeffler; Wei-Guo Zhu
Saw Palmetto induces growth arrest and apoptosis of androgen-dependent prostate cancer LNCaP cells via inactivation of STAT 3 and androgen receptor signaling.
International journal of oncology 2007;31(3):593-600.
2006: Yang Yang; Takayuki Ikezoe; Chie Nishioka; Takahiro Taguchi; Wei-Guo Zhu; H Phillip Koeffler; Hirokuni Taguchi
ZD6474 induces growth arrest and apoptosis of GIST-T1 cells, which is enhanced by concomitant use of sunitinib.
Cancer science 2006;97(12):1404-9.
2006: Quan Hui Zheng; Li Wei Ma; Wei-Guo Zhu; Zong Yu Zhang; Tan-jun Tong
p21Waf1/Cip1 plays a critical role in modulating senescence through changes of DNA methylation.
Journal of cellular biochemistry 2006;98(5):1230-48.
2006: Ying Zhao; Shaoli Lu; Lipeng Wu; Guolin Chai; Haiying Wang; Yingqi Chen; Jia Sun; Yu Yu; Wen Zhou; Quanhui Zheng; Mian Wu; Gregory A Otterson; Wei-Guo Zhu
Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1).
Molecular and cellular biology 2006;26(7):2782-90.
2004: Wenrui Duan; Li Gao; Lawrence J Druhan; Wei-Guo Zhu; Carl Morrison; Gregory A Otterson; Miguel A Villalona-Calero
Expression of Pirh2, a newly identified ubiquitin protein ligase, in lung cancer.
Journal of the National Cancer Institute 2004;96(22):1718-21.
2004: Zunyan Dai; Anthony P Popkie; Wei-Guo Zhu; Cynthia Timmers; Aparna Raval; Sarah H Tannehill-Gregg; Carl D Morrison; Herbert Auer; Robert A Kratzke; Gloria A Niehans; Stefan Amatschek; Wolfgang Sommergruber; Gustavo W Leone; Thomas J Rosol; Gregory A Otterson; Christoph Plass
Bone morphogenetic protein 3B silencing in non-small-cell lung cancer.
Oncogene 2004;23(20):3521-9.
2004: Wei-Guo Zhu; Theresa Hileman; Yang Ke; Peichang Wang; Shaoli Lu; Wenrui Duan; Zunyan Dai; Tanjun Tong; Miguel A Villalona-Calero; Christoph Plass; Gregory A Otterson
5-aza-2'-deoxycytidine activates the p53/p21Waf1/Cip1 pathway to inhibit cell proliferation.
The Journal of biological chemistry 2004;279(15):15161-6.
2003: Haiming Ding; Wenrui Duan; Wei-Guo Zhu; Rong Ju; Kanur Srinivasan; Gregory A Otterson; Miguel A Villalona-Calero
P21 response to DNA damage induced by genistein and etoposide in human lung cancer cells.
Biochemical and biophysical research communications 2003;305(4):950-6.
2003: Wei-Guo Zhu; Kanur Srinivasan; Zunyan Dai; Wenrui Duan; Lawrence J Druhan; Haiming Ding; Lisa Yee; Miguel A Villalona-Calero; Christoph Plass; Gregory A Otterson
Methylation of adjacent CpG sites affects Sp1/Sp3 binding and activity in the p21(Cip1) promoter.
Molecular and cellular biology 2003;23(12):4056-65.
2003: Wei-Guo Zhu; Gregory A Otterson
The interaction of histone deacetylase inhibitors and DNA methyltransferase inhibitors in the treatment of human cancer cells.
Current medicinal chemistry. Anti-cancer agents 2003;3(3):187-99.
2003: Zunyan Dai; Wei-Guo Zhu; Carl D Morrison; Romulo M Brena; Dominic J Smiraglia; Aparna Raval; Yue-Zhong Wu; Laura J Rush; Patrick Ross; Julian R Molina; Gregory A Otterson; Christoph Plass
A comprehensive search for DNA amplification in lung cancer identifies inhibitors of apoptosis cIAP1 and cIAP2 as candidate oncogenes.
Human molecular genetics 2003;12(7):791-801.
2002: Wenrui Duan; Haiming Ding; Mark A Subler; Wei-Guo Zhu; Huiming Zhang; Gary D Stoner; Jolene J Windle; Gregory A Otterson; Miguel A Villalona-Calero
Lung-specific expression of human mutant p53-273H is associated with a high frequency of lung adenocarcinoma in transgenic mice.
Oncogene 2002;21(51):7831-8.
2002: Wenrui Duan; H Ding; Wei-Guo Zhu; Kanur Srinivasan; Gregory A Otterson; Miguel A Villalona-Calero; G A Ottersom
RT-PCR heteroduplex analysis permits differentiation of transgene and host gene expression in a transgenic animal model.
BioTechniques 2002;33(1):58, 60-2, 64 passim.
2001: Wei-Guo Zhu; Zunyan Dai; Haiming Ding; Kanur Srinivasan; J Hall; Wenrui Duan; Miguel A Villalona-Calero; Christoph Plass; Gregory A Otterson
Increased expression of unmethylated CDKN2D by 5-aza-2'-deoxycytidine in human lung cancer cells.
Oncogene 2001;20(53):7787-96.
2001: Zunyan Dai; RR Lakshmanan; Wei-Guo Zhu; Dominic J Smiraglia; Laura J Rush; Michael C Frühwald; Romulo M Brena; B Li; Fred A Wright; Patrick Ross; Gregory A Otterson; Christoph Plass
Global methylation profiling of lung cancer identifies novel methylated genes.
Neoplasia (New York, N.Y.) 2001;3(4):314-23.
2001: Wei-Guo Zhu; RR Lakshmanan; M D Beal; Gregory A Otterson
DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors.
Cancer research 2001;61(4):1327-33.
2000: Yang Xia; Jeanie B McMillin; A Lewis; M Moore; Wei-Guo Zhu; R S Williams; Rodney E Kellems
Electrical stimulation of neonatal cardiac myocytes activates the NFAT3 and GATA4 pathways and up-regulates the adenylosuccinate synthetase 1 gene.
The Journal of biological chemistry 2000;275(3):1855-63.