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Xiaoxiang Zhu

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Nigel H Greig; Tony Giordano; Xiaoxiang Zhu; Qian-Sheng Yu; TracyAnn Perry; Harold W Holloway; Arnold Brossi; Jack T Rogers; Kumar Sambamurti; Debomoy K Lahiri
Thalidomide-based TNF-alpha inhibitors for neurodegenerative diseases.
Xiaoxiang Zhu; Tony Giordano; Qian-Sheng Yu; Harold W Holloway; TracyAnn Perry; Debomoy K Lahiri; Arnold Brossi; Nigel H Greig
Thiothalidomides: novel isosteric analogues of thalidomide with enhanced TNF-alpha inhibitory activity.
Charles P Gilman; Sic L Chan; Zhihong Guo; Xiaoxiang Zhu; Nigel H Greig; Mark P Mattson
p53 is present in synapses where it mediates mitochondrial dysfunction and synaptic degeneration in response to DNA damage, and oxidative and excitotoxic insults.

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2004: Nigel H Greig; Tony Giordano; Xiaoxiang Zhu; Qian-Sheng Yu; TracyAnn Perry; Harold W Holloway; Arnold Brossi; Jack T Rogers; Kumar Sambamurti; Debomoy K Lahiri
Thalidomide-based TNF-alpha inhibitors for neurodegenerative diseases.
Acta neurobiologiae experimentalis 2004;64(1):1-9.
2003: Xiaoxiang Zhu; Tony Giordano; Qian-Sheng Yu; Harold W Holloway; TracyAnn Perry; Debomoy K Lahiri; Arnold Brossi; Nigel H Greig
Thiothalidomides: novel isosteric analogues of thalidomide with enhanced TNF-alpha inhibitory activity.
Journal of medicinal chemistry 2003;46(24):5222-9.
2003: Charles P Gilman; Sic L Chan; Zhihong Guo; Xiaoxiang Zhu; Nigel H Greig; Mark P Mattson
p53 is present in synapses where it mediates mitochondrial dysfunction and synaptic degeneration in response to DNA damage, and oxidative and excitotoxic insults.
Neuromolecular medicine 2003;3(3):159-72.
2002: Xiaoxiang Zhu; Qian-Sheng Yu; Roy G Cutler; Carsten Culmsee; Harold W Holloway; Debomoy K Lahiri; Mark P Mattson; Nigel H Greig
Novel p53 inactivators with neuroprotective action: syntheses and pharmacological evaluation of 2-imino-2,3,4,5,6,7-hexahydrobenzothiazole and 2-imino-2,3,4,5,6,7-hexahydrobenzoxazole derivatives.
Journal of medicinal chemistry 2002;45(23):5090-7.
2002: WENZHEN DUAN; Xiaoxiang Zhu; Bruce Ladenheim; Qian-Sheng Yu; Zhihong Guo; Jonathan M Oyler; Roy G Cutler; Jean Lud Cadet; Nigel H Greig; Mark P Mattson
p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism.
Annals of neurology 2002;52(5):597-606.
2002: Qian-Sheng Yu; Xiaoxiang Zhu; Harold W Holloway; Noel F Whittaker; Arnold Brossi; Nigel H Greig
Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines.
Journal of medicinal chemistry 2002;45(17):3684-91.
2001: Carsten Culmsee; Xiaoxiang Zhu; Qian-Sheng Yu; Sic L Chan; Simonetta Camandola; Zhihong Guo; Nigel H Greig; Mark P Mattson
A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.
Journal of neurochemistry 2001;77(1):220-8.
2001: Nigel H Greig; Tada Utsuki; Q Yu; Xiaoxiang Zhu; Harold W Holloway; TracyAnn Perry; B Lee; Donald Ingram; Debomoy K Lahiri
A new therapeutic target in Alzheimer's disease treatment: attention to butyrylcholinesterase.
Current medical research and opinion 2001;17(3):159-65.