FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Yun-Fei Zhu

Research Profile

Chemicals & Drugs

Concepts & Ideas

Co-author Network

Publications

TOP 3
Chen Chen; Dongpei Wu; Zhiqiang Guo; Qiu Xie; Greg J Reinhart; Ajay Madan; Jenny Wen; Takung Chen; Charles Q Huang; Mi Chen; Yongsheng Chen; Fabio C Tucci; Martin W Rowbottom; Joseph Pontillo; Yun-Fei Zhu; Warren Wade; John Saunders; Haig Bozigian; R Scott Struthers
Discovery of sodium R-(+)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor.
Colin F Regan; Zhiqiang Guo; Yongsheng Chen; Charles Q Huang; Mi Chen; Wanlong Jiang; Jaimie K Rueter; Timothy Coon; Chen Chen; John Saunders; Michael S Brown; Stephen F Betz; R Scott Struthers; Chun Yang; Jenny Wen; Ajay Madan; Yun-Fei Zhu
Zwitterionic uracil derivatives as potent GnRH receptor antagonists with improved pharmaceutical properties.
Chen Chen; Yongsheng Chen; Joseph Pontillo; Zhiqiang Guo; Charles Q Huang; Dongpei Wu; Ajay Madan; Takung Chen; Jenny Wen; Qiu Xie; Fabio C Tucci; Martin W Rowbottom; Yun-Fei Zhu; Warren Wade; John Saunders; Haig Bozigian; R Scott Struthers
Potent and orally bioavailable zwitterion GnRH antagonists with low CYP3A4 inhibitory activity.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Yun-Fei Zhu (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2008: Chen Chen; Dongpei Wu; Zhiqiang Guo; Qiu Xie; Greg J Reinhart; Ajay Madan; Jenny Wen; Takung Chen; Charles Q Huang; Mi Chen; Yongsheng Chen; Fabio C Tucci; Martin W Rowbottom; Joseph Pontillo; Yun-Fei Zhu; Warren Wade; John Saunders; Haig Bozigian; R Scott Struthers
Discovery of sodium R-(+)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor.
Journal of medicinal chemistry 2008;51(23):7478-85.
2008: Colin F Regan; Zhiqiang Guo; Yongsheng Chen; Charles Q Huang; Mi Chen; Wanlong Jiang; Jaimie K Rueter; Timothy Coon; Chen Chen; John Saunders; Michael S Brown; Stephen F Betz; R Scott Struthers; Chun Yang; Jenny Wen; Ajay Madan; Yun-Fei Zhu
Zwitterionic uracil derivatives as potent GnRH receptor antagonists with improved pharmaceutical properties.
Bioorganic & medicinal chemistry letters 2008;18(16):4503-7.
2008: Chen Chen; Yongsheng Chen; Joseph Pontillo; Zhiqiang Guo; Charles Q Huang; Dongpei Wu; Ajay Madan; Takung Chen; Jenny Wen; Qiu Xie; Fabio C Tucci; Martin W Rowbottom; Yun-Fei Zhu; Warren Wade; John Saunders; Haig Bozigian; R Scott Struthers
Potent and orally bioavailable zwitterion GnRH antagonists with low CYP3A4 inhibitory activity.
Bioorganic & medicinal chemistry letters 2008;18(11):3301-5.
2008: Liren Zhao; Zhiqiang Guo; Yongsheng Chen; Tao Hu; Dongpei Wu; Yun-Fei Zhu; Martin W Rowbottom; Timothy D Gross; Fabio C Tucci; R Scott Struthers; Qiu Xie; Chen Chen
5-Aryluracils as potent GnRH antagonists-Characterization of atropisomers.
Bioorganic & medicinal chemistry letters 2008;18(11):3344-9.
2007: Marion Lanier; Miklos Feher; Neil J Ashweek; Colin J Loweth; Jaimie K Rueter; Deborah H Slee; John P Williams; Yun-Fei Zhu; Susan K Sullivan; Michael S Brown
Selection, synthesis, and structure-activity relationship of tetrahydropyrido[4,3-d]pyrimidine-2,4-diones as human GnRH receptor antagonists.
Bioorganic & medicinal chemistry 2007;15(16):5590-603.
2007: Trudy A Kohout; Qiu Xie; Shelby Reijmers; Kenneth J Finn; Zhiqiang Guo; Yun-Fei Zhu; R Scott Struthers
Trapping of a nonpeptide ligand by the extracellular domains of the gonadotropin-releasing hormone receptor results in insurmountable antagonism.
Molecular pharmacology 2007;72(2):238-47.
2007: Mi Chen; Zhiqiang Guo; Marion Lanier; Liren Zhao; Stephen F Betz; Charles Q Huang; Colin J Loweth; Neil J Ashweek; Xin-Jun Liu; R Scott Struthers; Margaret J Bradbury; James W Behan; Jenny Wen; Zhihong O'Brien; John Saunders; Yun-Fei Zhu
Identification of 2-(4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)-ethylamine derivatives as novel GnRH receptor antagonists.
Bioorganic & medicinal chemistry letters 2007;17(14):3845-50.
2007: R Scott Struthers; Qui Xie; Susan K Sullivan; Greg J Reinhart; Trudy A Kohout; Yun-Fei Zhu; Chen Chen; Xin-Jun Liu; Nicholas Ling; Weidong Yang; Richard A Maki; Anne K Bonneville; Ta Kung Chen; Haig Bozigian
Pharmacological characterization of a novel nonpeptide antagonist of the human gonadotropin-releasing hormone receptor, NBI-42902.
Endocrinology 2007;148(2):857-67.
2006: Stephen F Betz; Francisco M Lio; Yinghong Gao; Greg J Reinhart; Zhiqiang Guo; Michael F Mesleh; Yun-Fei Zhu; R Scott Struthers
Determination of the binding mode of thienopyrimidinedione antagonists to the human gonadotropin releasing hormone receptor using structure-activity relationships, site-directed mutagenesis, and homology modeling.
Journal of medicinal chemistry 2006;49(21):6170-6.
2006: Susan K Sullivan; Sam R J Hoare; Beth A Fleck; Yun-Fei Zhu; Christopher E Heise; R Scott Struthers; Paul Crowe
Kinetics of nonpeptide antagonist binding to the human gonadotropin-releasing hormone receptor: Implications for structure-activity relationships and insurmountable antagonism.
Biochemical pharmacology 2006;72(7):838-49.
2005: Fabio C Tucci; Tao Hu; Michael F Mesleh; Allan Bokser; Eric Allsopp; Timothy D Gross; Zhiqiang Guo; Yun-Fei Zhu; R Scott Struthers; Nicholas Ling; Chen Chen
Atropisomeric property of 1-(2,6-difluorobenzyl)-3-[(2R)-amino-2-phenethyl]-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil.
Chirality 2005;17(9):559-64.
2005: Charles Q Huang; Tracy Baker; David Schwarz; Jun Fan; Christopher E Heise; Mingzhu Zhang; Val S Goodfellow; Stacy Markison; Kathleen Gogas; Takung Chen; Xiao-Chuan Wang; Yun-Fei Zhu
1-(4-Amino-phenyl)-pyrrolidin-3-yl-amine and 6-(3-amino-pyrrolidin-1-yl)-pyridin-3-yl-amine derivatives as melanin-concentrating hormone receptor-1 antagonists.
Bioorganic & medicinal chemistry letters 2005;15(16):3701-6.
2005: Zhiqiang Guo; Dongpei Wu; Yun-Fei Zhu; Fabio C Tucci; Collin F Regan; Martin W Rowbottom; R Scott Struthers; Qiu Xie; Shelby Reijmers; Susan K Sullivan; Yang Sai; Chen Chen
Structure-activity relationships of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists.
Bioorganic & medicinal chemistry letters 2005;15(16):3685-90.
2005: Zhiqiang Guo; Yongsheng Chen; Charles Q Huang; Timothy D Gross; Joseph Pontillo; Martin W Rowbottom; John Saunders; Scott Struthers; Fabio C Tucci; Qiu Xie; Warren Wade; Yun-Fei Zhu; Dongpei Wu; Chen Chen
Uracils as potent antagonists of the human gonadotropin-releasing hormone receptor without atropisomers.
Bioorganic & medicinal chemistry letters 2005;15(10):2519-22.
2005: Fabio C Tucci; Yun-Fei Zhu; R Scott Struthers; Zhiqiang Guo; Timothy D Gross; Martin W Rowbottom; Oscar Acevedo; Yinghong Gao; John Saunders; Qiu Xie; Greg J Reinhart; Xin-Jun Liu; Nicholas Ling; Anne K L Bonneville; Takung Chen; Haig Bozigian; Chen Chen
3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)- 6-methylpyrimidin-2,4-dione (NBI 42902) as a potent and orally active antagonist of the human gonadotropin-releasing hormone receptor. Design, synthesis, and in vitro and in vivo characterization.
Journal of medicinal chemistry 2005;48(4):1169-78.
2005: Zhiqiang Guo; Dongpei Wu; Yun-Fei Zhu; Fabio C Tucci; Joseph Pontillo; John Saunders; Qiu Xie; R Scott Struthers; Chen Chen
A convenient one-pot synthesis of asymmetric 1,3,5-triazine-2,4,6-triones and its application towards a novel class of gonadotropin-releasing hormone receptor antagonists.
Bioorganic & medicinal chemistry letters 2005;15(3):693-8.
2004: Martin W Rowbottom; Fabio C Tucci; Patrick J Connors; Timothy D Gross; Yun-Fei Zhu; Zhiqiang Guo; Manisha Moorjani; Oscar Acevedo; Lee Carter; Susan K Sullivan; Qiu Xie; Andrew Fisher; R Scott Struthers; John Saunders; Chen Chen
Synthesis and structure-activity relationships of uracil derived human GnRH receptor antagonists: (R)-3-[2-(2-amino)phenethyl]-1-(2,6-difluorobenzyl)-6-methyluracils containing a substituted thiophene or thiazole at C-5.
Bioorganic & medicinal chemistry letters 2004;14(19):4967-73.
2004: Chen Chen; Keith M Wilcoxen; Charles Q Huang; Yun-Feng Xie; James R McCarthy; Thomas R Webb; Yun-Fei Zhu; John Saunders; Xin-Jun Liu; Ta Kung Chen; Haig Bozigian; Dimitri E Grigoriadis
Design of 2,5-dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and structure--activity relationships of a series of potent and orally active corticotropin-releasing factor receptor antagonists.
Journal of medicinal chemistry 2004;47(19):4787-98.
2004: Greg J Reinhart; Qiu Xie; Xin-Jun Liu; Yun-Fei Zhu; Jun Fan; Chen Chen; R Scott Struthers
Species selectivity of nonpeptide antagonists of the gonadotropin-releasing hormone receptor is determined by residues in extracellular loops II and III and the amino terminus.
The Journal of biological chemistry 2004;279(33):34115-22.
2004: Fabio C Tucci; Yun-Fei Zhu; Zhiqiang Guo; Timothy D Gross; Patrick J Connors; Yinghong Gao; Martin W Rowbottom; R Scott Struthers; Greg J Reinhart; Qiu Xie; Ta Kung Chen; Haig Bozigian; Anne L Killam Bonneville; Andrew Fisher; Liping Jin; John Saunders; Chen Chen
3-(2-aminoalkyl)-1-(2,6-difluorobenzyl)-5- (2-fluoro-3-methoxyphenyl)-6-methyl-uracils as orally bioavailable antagonists of the human gonadotropin releasing hormone receptor.
Journal of medicinal chemistry 2004;47(14):3483-6.
2004: Martin W Rowbottom; Fabio C Tucci; Yun-Fei Zhu; Zhiqiang Guo; Timothy D Gross; Greg J Reinhart; Qui Xie; R Scott Struthers; John Saunders; Chen Chen
Synthesis and structure-activity relationships of (R)-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as human GnRH receptor antagonists.
Bioorganic & medicinal chemistry letters 2004;14(9):2269-74.
2004: Zhiqiang Guo; Yun-Fei Zhu; Timothy D Gross; Fabio C Tucci; Yinghong Gao; Manisha Moorjani; Patrick J Connors; Martin W Rowbottom; Yongsheng Chen; R Scott Struthers; Qiu Xie; John Saunders; Greg Reinhart; Ta Kung Chen; Anne L Killam Bonneville; Chen Chen
Synthesis and structure-activity relationships of 1-arylmethyl-5-aryl-6-methyluracils as potent gonadotropin-releasing hormone receptor antagonists.
Journal of medicinal chemistry 2004;47(5):1259-71.
2003: Zhiqiang Guo; Yongsheng Chen; Dongpei Wu; Yun-Fei Zhu; R Scott Struthers; John Saunders; Qiu Xie; Chen Chen
Synthesis and structure-activity relationships of thieno[2,3-d]pyrimidine-2,4-dione derivatives as potent GnRH receptor antagonists.
Bioorganic & medicinal chemistry letters 2003;13(20):3617-22.
2003: Fabio C Tucci; Yun-Fei Zhu; Zhiqiang Guo; Timothy D Gross; Patrick J Connors; R Scott Struthers; Greg J Reinhart; John Saunders; Chen Chen
Synthesis and structure-activity relationships of 1-arylmethyl-3-(1-methyl-2-amino)ethyl-5-aryl-6-methyluracils as antagonists of the human GnRH Receptor.
Bioorganic & medicinal chemistry letters 2003;13(19):3317-22.
2003: Zhiqiang Guo; Yun-Fei Zhu; Fabio C Tucci; Yinghong Gao; R Scott Struthers; John Saunders; Timothy D Gross; Qiu Xie; Greg J Reinhart; Chen Chen
Synthesis and structure-activity relationships of 1-arylmethyl-3-(2-aminopropyl)-5-aryl-6-methyluracils as potent GnRH receptor antagonists.
Bioorganic & medicinal chemistry letters 2003;13(19):3311-5.
2003: Yun-Fei Zhu; Xiao-Chuan Wang; Patrick J Connors; Keith M Wilcoxen; Yinghong Gao; Raymond Gross; Nathalie Strack; Timothy Gross; James R McCarthy; Qiu Xie; Nicholas Ling; Chen Chen
Quinoline-carboxylic acids are potent inhibitors that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins.
Bioorganic & medicinal chemistry letters 2003;13(11):1931-4.
2003: Yun-Fei Zhu; Keith M Wilcoxen; Timothy Gross; Patrick J Connors; Nathalie Strack; Raymond Gross; Charles Q Huang; James R McCarthy; Qiu Xie; Nicholas Ling; Chen Chen
6,7-dihydroxyisoquinoline-3-carboxylic acids are potent inhibitors on the binding of insulin-like growth factor (IGF) to IGF-binding proteins: optimization of the 1-position benzoyl side chain.
Bioorganic & medicinal chemistry letters 2003;13(11):1927-30.
2003: Yun-Fei Zhu; Timothy D Gross; Zhiqiang Guo; Patrick J Connors; Yinghong Gao; Fabio C Tucci; R Scott Struthers; Greg J Reinhart; John Saunders; Ta Kung Chen; Anne L Killam Bonneville; Chen Chen
Identification of 1-arylmethyl-3- (2-aminoethyl)-5-aryluracil as novel gonadotropin-releasing hormone receptor antagonists.
Journal of medicinal chemistry 2003;46(11):2023-6.
2003: Yun-Fei Zhu; Zhiqiang Guo; Timothy D Gross; Yinghong Gao; Patrick J Connors; R Scott Struthers; Qiu Xie; Fabio C Tucci; Greg J Reinhart; Dongpei Wu; John Saunders; Chen Chen
Design and structure-activity relationships of 2-alkyl-3-aminomethyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists.
Journal of medicinal chemistry 2003;46(9):1769-72.
2002: Fabio C Tucci; Yun-Fei Zhu; Zhiqiang Guo; Timothy D Gross; Patrick J Connors; R Scott Struthers; Greg J Reinhart; Xiaochuan Wang; John Saunders; Chen Chen
A novel synthesis of 7-aryl-8-fluoro-pyrrolo[1,2-a]pyrimid-4-ones as potent, stable GnRH receptor antagonists.
Bioorganic & medicinal chemistry letters 2002;12(23):3491-5.
2002: Timothy D Gross; Yun-Fei Zhu; John Saunders; Keith M Wilcoxen; Yinghong Gao; Patrick J Connors; Zhiqiang Guo; R Scott Struthers; Greg J Reinhart; Chen Chen
Design, synthesis and structure-activity relationships of novel imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists.
Bioorganic & medicinal chemistry letters 2002;12(16):2185-7.
2002: Keith M Wilcoxen; Yun-Fei Zhu; Patrick J Connors; John Saunders; Timothy D Gross; Yinghong Gao; Greg J Reinhart; R Scott Struthers; Chen Chen
Synthesis and initial structure-activity relationships of a novel series of imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists.
Bioorganic & medicinal chemistry letters 2002;12(16):2179-83.
2002: Yun-Fei Zhu; Keith M Wilcoxen; John Saunders; Zhiqiang Guo; Yinghong Gao; Patrick J Connors; Timothy D Gross; Fabio C Tucci; R Scott Struthers; Greg J Reinhart; Qiu Xie; Chen Chen
A novel synthesis of 2-arylpyrrolo[1,2-a]pyrimid-7-ones and their structure-activity relationships as potent GnRH receptor antagonists.
Bioorganic & medicinal chemistry letters 2002;12(3):403-6.
2002: Yun-Fei Zhu; R Scott Struthers; Patrick J Connors; Yinghong Gao; Timothy D Gross; John Saunders; Keith M Wilcoxen; Greg J Reinhart; Nicholas Ling; Chen Chen
Initial structure-activity relationship studies of a novel series of pyrrolo[1,2-a]pyrimid-7-ones as GnRH receptor antagonists.
Bioorganic & medicinal chemistry letters 2002;12(3):399-402.
2001: Chen Chen; Yun-Fei Zhu; X J Liu; Z X Lu; Qiu Xie; Nicholas Ling
Discovery of a series of nonpeptide small molecules that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins.
Journal of medicinal chemistry 2001;44(23):4001-10.
2000: Chen Chen; Yun-Fei Zhu; Keith M Wilcoxen
An improved synthesis of selectively protected L-dopa derivatives from L-tyrosine.
The Journal of organic chemistry 2000;65(8):2574-6.