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Ronald Zielke

Research Profile

Living Beings

Chemicals & Drugs

Anatomy

Procedures

Microdialysis

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Oxidation-Reduction

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Publications

TOP 3
Luo Zhuo; H Ronald Zielke; Xiang Zhang; Yang Zhang; Lin Chang; David Fowler; Barry Levine; Ling Li
Sudden unexpected death in epilepsy: Evaluation of forensic autopsy cases.
Michael J Hawrylycz; David R Haynor; Patrick R Hof; John G Hohmann; Steve Horvath; Robert E Howard; Andreas Jeromin; Jayson M Jochim; Chris Abajian; Christian F Beckmann; Amy Bernard; Darren Bertagnolli; Andrew F Boe; Preston M Cartagena; M Mallar Chakravarty; Mike Chapin; Jimmy Chong; Rachel A Dalley; Barry Daly; Chinh Dang; Suvro Datta; Nick Dee; Tim A Dolbeare; Amanda Ebbert; Vance Faber; David Feng; David R Fowler; Daniel H Geschwind; Jeff Goldy; Seth G N Grant; Benjamin W Gregor; Angela L Guillozet-Bongaarts; Zeb Haradon; Marty Kinnunen; Christof Koch; Christopher Lau; Evan T Lazarz; Changkyu Lee; Ed Lein; Tracy A Lemon; Ling Li; Yang Li; Jeremy A Miller; John A Morris; Lydia Ng; Caroline C Overly; Patrick D Parker; Sheana E Parry; Melissa Reding; Zackery L Riley; Joshua J Royall; Jay Schulkin; Pedro Adolfo Sequeira; Elaine H Shen; Clifford R Slaughterbeck; Kimberly A Smith; Simon C Smith; Stephen M Smith; Andy J Sodt; Susan M Sunkin; Beryl E Swanson; Louie van de Lagemaat; Marquis P Vawter; Derric Williams; Paul Wohnoutka; H Ronald Zielke; Allan R Jones
An anatomically comprehensive atlas of the adult human brain transcriptome.
Ling Li; Xiang Zhang; H Ronald Zielke; Barry S Levine; Guohua Li; David R Fowler
Trends and pattern of drug abuse deaths in Maryland teenagers.

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All Publications

2012: Luo Zhuo; H Ronald Zielke; Xiang Zhang; Yang Zhang; Lin Chang; David Fowler; Barry Levine; Ling Li
Sudden unexpected death in epilepsy: Evaluation of forensic autopsy cases.
Forensic science international 2012;223(1-3):171-5.
2012: Michael J Hawrylycz; David R Haynor; Patrick R Hof; John G Hohmann; Steve Horvath; Robert E Howard; Andreas Jeromin; Jayson M Jochim; Chris Abajian; Christian F Beckmann; Amy Bernard; Darren Bertagnolli; Andrew F Boe; Preston M Cartagena; M Mallar Chakravarty; Mike Chapin; Jimmy Chong; Rachel A Dalley; Barry Daly; Chinh Dang; Suvro Datta; Nick Dee; Tim A Dolbeare; Amanda Ebbert; Vance Faber; David Feng; David R Fowler; Daniel H Geschwind; Jeff Goldy; Seth G N Grant; Benjamin W Gregor; Angela L Guillozet-Bongaarts; Zeb Haradon; Marty Kinnunen; Christof Koch; Christopher Lau; Evan T Lazarz; Changkyu Lee; Ed Lein; Tracy A Lemon; Ling Li; Yang Li; Jeremy A Miller; John A Morris; Lydia Ng; Caroline C Overly; Patrick D Parker; Sheana E Parry; Melissa Reding; Zackery L Riley; Joshua J Royall; Jay Schulkin; Pedro Adolfo Sequeira; Elaine H Shen; Clifford R Slaughterbeck; Kimberly A Smith; Simon C Smith; Stephen M Smith; Andy J Sodt; Susan M Sunkin; Beryl E Swanson; Louie van de Lagemaat; Marquis P Vawter; Derric Williams; Paul Wohnoutka; H Ronald Zielke; Allan R Jones
An anatomically comprehensive atlas of the adult human brain transcriptome.
Nature 2012;489(7416):391-9.
2011: Ling Li; Xiang Zhang; H Ronald Zielke; Barry S Levine; Guohua Li; David R Fowler
Trends and pattern of drug abuse deaths in Maryland teenagers.
Journal of forensic sciences 2011;56(4):1029-33.
2011: Ling Li; Allen P Burke; Jie He; Lin Chang; H Ronald Zielke; David R Fowler
Sudden unexpected death due to inflammatory myofibroblastic tumor of the heart: a case report and review of the literature.
International journal of legal medicine 2011;125(1):81-5.
2010: J Raphael Gibbs; Marcel P van der Brug; Dena G Hernandez; Bryan Joseph Traynor; Michael A Nalls; Shiao-Lin Lai; Sampath Arepalli; Allissa Dillman; Ian P Rafferty; Juan C Troncoso; Robert Johnson; H Ronald Zielke; Luigi Ferrucci; Dan L Longo; Mark Cookson; Andrew Singleton
Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain.
PLoS genetics 2010;6(5):e1000952.
2009: Luis E F Almeida; Peter Murray; H Ronald Zielke; Clinton D Roby; Tami J Kingsbury; Bruce K Krueger
Autocrine activation of neuronal NMDA receptors by aspartate mediates dopamine- and cAMP-induced CREB-dependent gene transcription.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(40):12702-10.
2009: Tamara Blutstein; Peter J Baab; H Ronald Zielke; Jessica Mong
Hormonal modulation of amino acid neurotransmitter metabolism in the arcuate nucleus of the adult female rat: a novel action of estradiol.
Endocrinology 2009;150(7):3237-44.
2009: H Ronald Zielke; Carol L Zielke; Peter J Baab
Direct measurement of oxidative metabolism in the living brain by microdialysis: a review.
Journal of neurochemistry 2009;109 Suppl 1():24-9.
2008: Nicole C Berchtold; David H Cribbs; Paul D. Coleman; Joseph Rogers; Elizabeth Head; Ronald Kim; Thomas Beach; Carol Miller; Juan C Troncoso; John Q Trojanowski; H Ronald Zielke; Carl W Cotman
Gene expression changes in the course of normal brain aging are sexually dimorphic.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(40):15605-10.
2007: H Ronald Zielke; Carol L Zielke; Peter J Baab
Oxidation of (14)C-labeled compounds perfused by microdialysis in the brains of free-moving rats.
Journal of neuroscience research 2007;85(14):3145-9.
2007: H Ronald Zielke; Carol L Zielke; Peter J Baab; J Tyson Tildon
Effect of fluorocitrate on cerebral oxidation of lactate and glucose in freely moving rats.
Journal of neurochemistry 2007;101(1):9-16.
2007: Christopher Matthews; H Ronald Zielke; Paul S Fishman; Mary P Remington; Thomas G Bowen
Glutamate decarboxylase protects neurons against excitotoxic injury.
Journal of neuroscience research 2007;85(4):855-9.
2006: Hendrik J Vreman; Ronald J Wong; David K Stevenson; John E Smialek; David R Fowler; Ling Li; Robert D Vigorito; H Ronald Zielke
Concentration of carbon monoxide (CO) in postmortem human tissues: effect of environmental CO exposure.
Journal of forensic sciences 2006;51(5):1182-90.
2005: Takahiro Takano; Jian Kang; Jyoti K Jaiswal; Sanford M Simon; Jane H-C Lin; Yufei Yu; Yuxing Li; Jay Yang; Gerald A Dienel; H Ronald Zielke; Maiken Nedergaard
Receptor-mediated glutamate release from volume sensitive channels in astrocytes.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(45):16466-71.
2005: Guo-Feng Tian; Hooman Azmi; Takahiro Takano; Qiwu Xu; Weiguo Peng; Jane Lin; NancyAnn Oberheim; Nanhong Lou; xiaohai wang; H Ronald Zielke; Jian Kang; Maiken Nedergaard
An astrocytic basis of epilepsy.
Nature medicine 2005;11(9):973-81.
2005: Fernando V Mena; Peter J Baab; Carol L Zielke; Yinyin Huang; H Ronald Zielke
Formation of extracellular glutamate from glutamine: exclusion of pyroglutamate as an intermediate.
Brain research 2005;1052(1):88-96.
2005: Tammara L Watts; Irene Berti; Anna Sapone; Tania Gerarduzzi; Tarcisio Not; H Ronald Zielke; Alessio Fasano
Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):2916-21.
2005: Nancy F Cruz; Amelia Lasater; H Ronald Zielke; Gerald A Dienel
Activation of astrocytes in brain of conscious rats during acoustic stimulation: acetate utilization in working brain.
Journal of neurochemistry 2005;92(4):934-47.
2004: Leif Hertz; H Ronald Zielke
Astrocytic control of glutamatergic activity: astrocytes as stars of the show.
Trends in neurosciences 2004;27(12):735-43.
2004: L Tchakmakjian; Jeffrey P Gardner; P D Wilson; M Kimura; Joan Skurnick; H Ronald Zielke; Abraham Aviv
Age-dependent telomere attrition as a potential indicator of racial differences in renal growth patterns.
Nephron. Experimental nephrology 2004;98(3):e82-8.
2003: Christopher Matthews; H Ronald Zielke; Deborah A Parks; Paul S Fishman
Glutamate-pyruvate transaminase protects against glutamate toxicity in hippocampal slices.
Brain research 2003;978(1-2):59-64.
2003: Rong Mao; Carol L Zielke; H Ronald Zielke; Jonathan Pevsner
Global up-regulation of chromosome 21 gene expression in the developing Down syndrome brain.
Genomics 2003;81(5):457-67.
2003: Kimberly L Jones; Henry F Krous; Julie Nadeau; Brian D Blackbourne; H Ronald Zielke; David Gozal
Vascular endothelial growth factor in the cerebrospinal fluid of infants who died of sudden infant death syndrome: evidence for antecedent hypoxia.
Pediatrics 2003;111(2):358-63.
2003: C Kiss; Gianpiera Ceresoli-Borroni; Paolo Guidetti; Carol L Zielke; H Ronald Zielke; Robert Schwarcz
Kynurenate production by cultured human astrocytes.
Journal of neural transmission (Vienna, Austria : 1996) 2003;110(1):1-14.
2002: Robert G Meny; Hendrik J Vreman; David K Stevenson; Fern R Hauck; Edmund R. Donoghue; John E Smialek; David R Fowler; H Ronald Zielke
Failure to detect elevated levels of carboxyhemoglobin in infants dying from SIDS.
Journal of forensic sciences 2002;47(3):660-2.
2002: H Ronald Zielke; Carol L Zielke; Peter J Baab; Roger M Collins
Large neutral amino acids auto exchange when infused by microdialysis into the rat brain: implication for maple syrup urine disease and phenylketonuria.
Neurochemistry international 2002;40(4):347-54.
2000: Christopher Matthews; H Ronald Zielke; J B Wollack; Paul S Fishman
Enzymatic degradation protects neurons from glutamate excitotoxicity.
Journal of neurochemistry 2000;75(3):1045-52.
2000: Fernando V Mena; Peter J Baab; Carol L Zielke; H Ronald Zielke
In vivo glutamine hydrolysis in the formation of extracellular glutamate in the injured rat brain.
Journal of neuroscience research 2000;60(5):632-41.
2000: Ruiliang Lu; W Wang; Sergio Uzzau; Robert D Vigorito; H Ronald Zielke; Alessio Fasano
Affinity purification and partial characterization of the zonulin/zonula occludens toxin (Zot) receptor from human brain.
Journal of neurochemistry 2000;74(1):320-6.
1999: PS Hodgkins; Hui-Qiu Wu; H Ronald Zielke; Robert Schwarcz
2-Oxoacids regulate kynurenic acid production in the rat brain: studies in vitro and in vivo.
Journal of neurochemistry 1999;72(2):643-51.
1998: H Ronald Zielke; Roger M Collins; Peter J Baab; Yinyin Huang; Carol L Zielke; J Tyson Tildon
Compartmentation of [14C]glutamate and [14C]glutamine oxidative metabolism in the rat hippocampus as determined by microdialysis.
Journal of neurochemistry 1998;71(3):1315-20.
1998: Mary C McKenna; Ursula Sonnewald; X Huang; J Stevenson; S F Johnsen; L M Sande; H Ronald Zielke
Alpha-ketoisocaproate alters the production of both lactate and aspartate from [U-13C]glutamate in astrocytes: a 13C NMR study.
Journal of neurochemistry 1998;70(3):1001-8.
1997: H Ronald Zielke; Yinyin Huang; Peter J Baab; Roger M Collins; Carol L Zielke; J Tyson Tildon
Effect of alpha-ketoisocaproate and leucine on the in vivo oxidation of glutamate and glutamine in the rat brain.
Neurochemical research 1997;22(9):1159-64.
1996: M J Jackson; H Ronald Zielke; Carol L Zielke
Induction of astrocyte argininosuccinate synthetase and argininosuccinate lyase by dibutyryl cyclic AMP and dexamethasone.
Neurochemical research 1996;21(10):1161-5.
1996: H Ronald Zielke; S Wisniewski; S A Stein
Brief report: the role of National Brain and Tissue Banks in research on autism and developmental disorders.
Journal of autism and developmental disorders 1996;26(2):227-30.
1996: H Ronald Zielke; Y Huang; J Tyson Tildon; Carol L Zielke; Peter J Baab
Elevation of amino acids in the interstitial space of the rat brain following infusion of large neutral amino and keto acids by microdialysis: alpha-ketoisocaproate infusion.
Developmental neuroscience 1996;18(5-6):420-5.
1996: Y Huang; H Ronald Zielke; J Tyson Tildon; Carol L Zielke; Peter J Baab
Elevation of amino acids in the interstitial space of the rat brain following infusion of large neutral amino and keto acids by microdialysis: leucine infusion.
Developmental neuroscience 1996;18(5-6):415-9.
1996: H Ronald Zielke; J Tyson Tildon; Carol L Zielke
Use of intracellular versus extracellular specific activities in calculation of glutamine metabolism in astrocytes: effect of dibutyryl cyclic AMP.
Developmental neuroscience 1996;18(3):224-30.
1996: Z Li; Ling Li; H Ronald Zielke; Linda Cheng; R Xiao; Michael T Crow; William Stetler-Stevenson; James B Froehlich; Edward G Lakatta
Increased expression of 72-kd type IV collagenase (MMP-2) in human aortic atherosclerotic lesions.
The American journal of pathology 1996;148(1):121-8.
1996: Mary C McKenna; U Sonnewald; X Huang; J Stevenson; H Ronald Zielke
Exogenous glutamate concentration regulates the metabolic fate of glutamate in astrocytes.
Journal of neurochemistry 1996;66(1):386-93.
1995: M J Jackson; H Ronald Zielke; S R Max
Effect of dibutyryl cyclic AMP and dexamethasone on glutamine synthetase gene expression in rat astrocytes in culture.
Neurochemical research 1995;20(2):201-7.
1994: R M Collins; H Ronald Zielke; R C Woody
Valproate increases glutaminase and decreases glutamine synthetase activities in primary cultures of rat brain astrocytes.
Journal of neurochemistry 1994;62(3):1137-43.
1993: H Ronald Zielke; M J Jackson; J Tyson Tildon; S R Max
A glutamatergic mechanism for aluminum toxicity in astrocytes.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1993;19(3):219-33.
1993: Richard P Shank; G C Leo; H Ronald Zielke
Cerebral metabolic compartmentation as revealed by nuclear magnetic resonance analysis of D-[1-13C]glucose metabolism.
Journal of neurochemistry 1993;61(1):315-23.
1993: Y Huang; Carol L Zielke; J Tyson Tildon; H Ronald Zielke
Monitoring in vivo oxidation of 14C-labelled substrates to 14CO2 by brain microdialysis.
Developmental neuroscience 1993;15(3-5):233-9.
1990: H Ronald Zielke; J Tyson Tildon; M E Landry; S R Max
Effect of 8-bromo-cAMP and dexamethasone on glutamate metabolism in rat astrocytes.
Neurochemical research 1990;15(11):1115-22.
1990: S R Max; M E Landry; H Ronald Zielke
Induction of glutamine synthetase by 8-bromo cyclic AMP in primary cultures of rat brain astrocytes.
Neurochemical research 1990;15(6):583-6.
1989: H Ronald Zielke; R G Meny; M J O'Brien; John E Smialek; Ferdane Kutlar; T H Huisman; George J Dover
Normal fetal hemoglobin levels in the sudden infant death syndrome.
The New England journal of medicine 1989;321(20):1359-64.
1989: H Ronald Zielke; J Tyson Tildon; Carol L Zielke; Peter J Baab; M E Landry
Functional intracellular glutaminase activity in intact astrocytes.
Neurochemical research 1989;14(4):327-32.
1989: H Ronald Zielke; J Tyson Tildon; F C Kauffman; Peter J Baab
Effect of nerve growth factor on the synthesis of amino acids in PC12 cells.
Journal of neuroscience research 1989;22(4):418-24.
1989: H Ronald Zielke; J Tyson Tildon; Peter J Baab; I B Hopkins
Synthesis of glutamate and glutamine in dibutyryl cyclic AMP-treated astrocytes.
Neuroscience letters 1989;97(1-2):209-14.
1987: Carol L Zielke; H Ronald Zielke
Chronic exposure to subcutaneously implanted methylxanthines. Differential elevation of A1-adenosine receptors in mouse cerebellar and cerebral cortical membranes.
Biochemical pharmacology 1987;36(15):2533-8.
1986: H Ronald Zielke; Carol L Zielke
Lack of a sustained effect on catecholamines or indoles in mouse brain after long term subcutaneous administration of caffeine and theophylline.
Life sciences 1986;39(6):565-72.
1985: H Ronald Zielke
Determination of amino acids in the brain by high-performance liquid chromatography with isocratic elution and electrochemical detection.
Journal of chromatography 1985;347(2):320-4.
1984: H Ronald Zielke; Carol L Zielke; P T Ozand
Glutamine: a major energy source for cultured mammalian cells.
Federation proceedings 1984;43(1):121-5.
1983: Carlota Sumbilla; H Ronald Zielke; B L Krause; P T Ozand
Gluconeogenic enzymes in fibroblasts from infants dying of the sudden infant death syndrome (SIDS).
European journal of pediatrics 1983;140(3):276-7.
1982: Carol L Zielke; H Ronald Zielke; P T Ozand
A radioisotope assay for L-glutaminase: the measurement of tritiated water formation from the reaction of L-[2-3H]glutamine with the L-glutaminase and glutamate oxalacetate transaminase couple.
Analytical biochemistry 1982;127(1):134-42.
1981: W D Reed; H Ronald Zielke; Peter J Baab; P T Ozand
Ketone bodies, glucose and glutamine as lipogenic precursors in human diploid fibroblasts.
Lipids 1981;16(9):677-84.
1981: T P Pula; S R Max; H Ronald Zielke; M Chacon; Peter J Baab; M Gumbinas; W D Reed
Selective carnitine palmitoyltransferase deficiency in fibroblasts from a patient with muscle CPT deficiency.
Annals of neurology 1981;10(2):196-8.
1981: Carlota Sumbilla; Carol L Zielke; W D Reed; P T Ozand; H Ronald Zielke
Comparison of the oxidation of glutamine, glucose, ketone bodies and fatty acids by human diploid fibroblasts.
Biochimica et biophysica acta 1981;675(2):301-4.
1981: H Ronald Zielke; Carlota Sumbilla; P T Ozand
Effect of glucose on aspartate and glutamate synthesis by human diploid fibroblasts.
Journal of cellular physiology 1981;107(2):251-4.
1981: Carlota Sumbilla; P T Ozand; H Ronald Zielke
Activities of enzymes required for the conversion of 4-carbon TCA cycle compounds to 3-carbon glycolytic compounds in human diploid fibroblasts.
Enzyme 1981;26(4):201-5.
1980: H Ronald Zielke; Carlota Sumbilla; D A Sevdalian; R L Hawkins; P T Ozand
Lactate: a major product of glutamine metabolism by human diploid fibroblasts.
Journal of cellular physiology 1980;104(3):433-41.
1980: D A Sevdalian; P T Ozand; H Ronald Zielke
Increase in glutaminase activity during the growth cycle of cultured human diploid fibroblasts.
Enzyme 1980;25(2):142-4.
1979: H Ronald Zielke
Isolation of thymidine-resistant cells from a thymidine-sensitive acute lymphoblastic leukemia cell line.
Cancer research 1979;39(9):3373-6.
1979: H Ronald Zielke; P T Ozand; R E Luddy; W H Zinkham; ALLEN SCHWARTZ; D A Sevdalian
Elevation of pyrimidine enzyme activities in the RBC of patients with congenital hypoplastic anaemia and their parents.
British journal of haematology 1979;42(3):381-90.
1978: D A Sevdalian; H Ronald Zielke
Depletion of cellular glycogen during the early logarithmic growth phase of human fibroblasts.
Experientia 1978;34(7):843-4.
1978: H Ronald Zielke; P T Ozand; J Tyson Tildon; D A Sevdalian; M Cornblath
Reciprocal regulation of glucose and glutamine utilization by cultured human diploid fibroblasts.
Journal of cellular physiology 1978;95(1):41-8.
1976: H Ronald Zielke; P T Ozand; J Tyson Tildon; D A Sevdalian; M Cornblath
Growth of human diploid fibroblasts in the absence of glucose utilization.
Proceedings of the National Academy of Sciences of the United States of America 1976;73(11):4110-4.
1976: H Ronald Zielke; S C Hong; J W Littlefield
Different timing of increases in activities of four X-chromosome linked enzymes during the cell cycle of synchronized human lymphoblasts.
Experimental cell research 1976;97(2):426-30.
1974: H Ronald Zielke; J W Littlefield
Repetitive synchronization of human lymphoblast cultures with excess thymidine.
Methods in cell biology 1974;8(0):107-121.
1971: H Ronald Zielke; P Filner
Synthesis and turnover of nitrate reductase induced by nitrate in cultured tobacco cells.
The Journal of biological chemistry 1971;246(6):1772-9.
1969: H Ronald Zielke; C M Reinke; R U Byerrum
Incorporation of carbon dioxide and acetate into the pyridine ring of nicotine.
The Journal of biological chemistry 1969;244(1):95-8.
1968: H Ronald Zielke; R U Byerrum; R M O'Neal; L C Burns; R E Koeppe
Incorporation of carbon dioxide and acetate into the pyrrolidine ring of nicotine.
The Journal of biological chemistry 1968;243(18):4757-61.