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Basilia Zingarelli

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Pengfei Li; Richard Neubig; Basilia Zingarelli; KT Borg; James A Cook; Perry V Halushka; Hongkuan Fan
Toll-like receptor-induced inflammatory cytokines are suppressed by gain of function or overexpression of Gα(i2) protein.
Jennifer M Kaplan; Patrick Lahni; Marchele Nowell; Michael P O'Connor; Paul W Hake; Basilia Zingarelli
Short-term high fat feeding increases organ injury and mortality after polymicrobial sepsis.
Stephen W Standage; Charles C Caldwell; Basilia Zingarelli; Hector R Wong
Reduced peroxisome proliferator-activated receptor α expression is associated with decreased survival and increased tissue bacterial load in sepsis.

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2012: Pengfei Li; Richard Neubig; Basilia Zingarelli; KT Borg; James A Cook; Perry V Halushka; Hongkuan Fan
Toll-like receptor-induced inflammatory cytokines are suppressed by gain of function or overexpression of Gα(i2) protein.
Inflammation 2012;35(5):1611-7.
2012: Jennifer M Kaplan; Patrick Lahni; Marchele Nowell; Michael P O'Connor; Paul W Hake; Basilia Zingarelli
Short-term high fat feeding increases organ injury and mortality after polymicrobial sepsis.
Obesity (Silver Spring, Md.) 2012;20(10):1995-2002.
2012: Stephen W Standage; Charles C Caldwell; Basilia Zingarelli; Hector R Wong
Reduced peroxisome proliferator-activated receptor α expression is associated with decreased survival and increased tissue bacterial load in sepsis.
Shock (Augusta, Ga.) 2012;37(2):164-9.
2012: Patrick D Solan; Alvin Denenberg; Katherine E Dunsmore; Kelli Odoms; Basilia Zingarelli; Hector R Wong
A novel role for matrix metalloproteinase-8 in sepsis.
Critical care medicine 2012;40(2):379-87.
2011: Ranjit S Chima; Timberly LaMontagne; Giovanna Piraino; Paul W Hake; Alvin Denenberg; Basilia Zingarelli
C-peptide, a novel inhibitor of lung inflammation following hemorrhagic shock.
American journal of physiology. Lung cellular and molecular physiology 2011;300(5):L730-9.
2011: Ranjit S Chima; Giuseppe Maltese; Timberly Lamontagne; Giovanna Piraino; Alvin Denenberg; Michael O'Connor; Basilia Zingarelli
C-peptide ameliorates kidney injury following hemorrhagic shock.
Shock (Augusta, Ga.) 2011;35(5):524-9.
2011: Patrick D Solan; Giovanna Piraino; Paul W Hake; Alvin Denenberg; Michael O'Connor; Alex Lentsch; Basilia Zingarelli
Liver X receptor α activation with the synthetic ligand T0901317 reduces lung injury and inflammation after hemorrhage and resuscitation via inhibition of the nuclear factor κB pathway.
Shock (Augusta, Ga.) 2011;35(4):367-74.
2011: Basilia Zingarelli
What's new in SHOCK, March 2011?
Shock (Augusta, Ga.) 2011;35(3):217-9.
2011: Hongkuan Fan; Pengfei Li; Basilia Zingarelli; Keith Borg; Perry V Halushka; Lutz Birnbaumer; James A Cook
Heterotrimeric Gα(i) proteins are regulated by lipopolysaccharide and are anti-inflammatory in endotoxemia and polymicrobial sepsis.
Biochimica et biophysica acta 2011;1813(3):466-72.
2011: Derek S Wheeler; John S Giuliano; Patrick M Lahni; Alvin Denenberg; Hector R Wong; Basilia Zingarelli
The immunomodulatory effects of albumin in vitro and in vivo.
Advances in pharmacological sciences 2011;2011():691928.
2011: Rajesh K Aneja; Hanna Sjodin; Julia V Gefter; Basilia Zingarelli; Russell L Delude
Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line.
Journal of inflammation (London, England) 2011;8():3.
2010: Jennifer M Kaplan; Paul W Hake; Alvin Denenberg; Marchele Nowell; Giovanna Piraino; Basilia Zingarelli
Phosphorylation of extracellular signal-regulated kinase (ERK)-1/2 Is associated with the downregulation of peroxisome proliferator-activated receptor (PPAR)-γ during polymicrobial sepsis.
Molecular medicine (Cambridge, Mass.) 2010;16(11-12):491-7.
2010: Ranjit S Chima; Basilia Zingarelli
Toll-like receptor-2 and disturbances of the cardiac rhythm: life changes in a heartbeat.
Critical care medicine 2010;38(10):2062-3.
2010: Basilia Zingarelli; Giovanna Piraino; Paul W Hake; Michael O'Connor; Alvin Denenberg; Hongkuan Fan; James A Cook
Peroxisome proliferator-activated receptor {delta} regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsis.
The American journal of pathology 2010;177(4):1834-47.
2010: Hongkuan Fan; Alessandra Bitto; Basilia Zingarelli; Louis M Luttrell; KT Borg; Perry V Halushka; James A Cook
Beta-arrestin 2 negatively regulates sepsis-induced inflammation.
Immunology 2010;130(3):344-51.
2010: Ranjit S Chima; Paul W Hake; Giovanna Piraino; Prajakta Mangeshkar; Michael O'Connor; Basilia Zingarelli
Ciglitazone, a novel inhibitor of lung apoptosis following hemorrhagic shock.
International journal of clinical and experimental medicine 2010;3(1):1-9.
2010: Basilia Zingarelli; Ranjit Chima; Michael O'Connor; Giovanna Piraino; Alvin Denenberg; Paul W Hake
Liver apoptosis is age dependent and is reduced by activation of peroxisome proliferator-activated receptor-gamma in hemorrhagic shock.
American journal of physiology. Gastrointestinal and liver physiology 2010;298(1):G133-41.
2010: Jennifer M Kaplan; Alvin Denenberg; Marie Monaco; Marchele Nowell; Hector Wong; Basilia Zingarelli
Changes in peroxisome proliferator-activated receptor-gamma activity in children with septic shock.
Intensive care medicine 2010;36(1):123-30.
2009: Xiaohong Wang; Basilia Zingarelli; Michael O'Connor; Pengyuan Zhang; Adeola Adeyemo; Evangelia G Kranias; Yigang Wang; Guo-Chang Fan
Overexpression of Hsp20 prevents endotoxin-induced myocardial dysfunction and apoptosis via inhibition of NF-kappaB activation.
Journal of molecular and cellular cardiology 2009;47(3):382-90.
2009: Derek S Wheeler; Basilia Zingarelli; William J Wheeler; Hector R Wong
Novel pharmacologic approaches to the management of sepsis: targeting the host inflammatory response.
Recent patents on inflammation & allergy drug discovery 2009;3(2):96-112.
2009: Basilia Zingarelli; Paul W Hake; Michael O'Connor; Timothy J Burroughs; Hector R Wong; Joseph S Solomkin; Alex B Lentsch
Lung injury after hemorrhage is age dependent: role of peroxisome proliferator-activated receptor gamma.
Critical care medicine 2009;37(6):1978-87.
2008: Ranjit S Chima; Paul W Hake; Giovanna Piraino; Prajakta Mangeshkar; Alvin Denenberg; Basilia Zingarelli
Ciglitazone ameliorates lung inflammation by modulating the inhibitor kappaB protein kinase/nuclear factor-kappaB pathway after hemorrhagic shock.
Critical care medicine 2008;36(10):2849-57.
2008: Derek S Wheeler; Patrick M Lahni; Alvin Denenberg; Sue E Poynter; Hector R Wong; James A Cook; Basilia Zingarelli
Induction of endotoxin tolerance enhances bacterial clearance and survival in murine polymicrobial sepsis.
Shock (Augusta, Ga.) 2008;30(3):267-73.
2008: Hongkuan Fan; Basilia Zingarelli; Vashaunta Harris; George E Tempel; Perry V Halushka; James A Cook
Lysophosphatidic acid inhibits bacterial endotoxin-induced pro-inflammatory response: potential anti-inflammatory signaling pathways.
Molecular medicine (Cambridge, Mass.) 2008;14(7-8):422-8.
2008: Jose Irazuzta; Robert K Pretzlaff; Basilia Zingarelli
Caspases inhibition decreases neurological sequelae in meningitis.
Critical care medicine 2008;36(5):1603-6.
2008: Basilia Zingarelli; Hongkuan Fan; Sarah Ashton; Giovanna Piraino; Prajakta Mangeshkar; James A Cook
Peroxisome proliferator activated receptor gamma is not necessary for the development of LPS-induced tolerance in macrophages.
Immunology 2008;124(1):51-7.
2008: Patricia A Abboud; Paul W Hake; Timothy J Burroughs; Kelli Odoms; Michael O'Connor; Prajakta Mangeshkar; Hector R Wong; Basilia Zingarelli
Therapeutic effect of epigallocatechin-3-gallate in a mouse model of colitis.
European journal of pharmacology 2008;579(1-3):411-7.
2008: Satoshi Kuboki; Thomas Shin; Nadine Huber; Thorsten Eismann; Elizabeth Galloway; Rebecca Schuster; John Blanchard; Basilia Zingarelli; Alex B Lentsch
Peroxisome proliferator-activated receptor-gamma protects against hepatic ischemia/reperfusion injury in mice.
Hepatology (Baltimore, Md.) 2008;47(1):215-24.
2007: John S Giuliano; Patrick M Lahni; Kelli Harmon; Hector R Wong; Lesley A Doughty; Joseph A Carcillo; Basilia Zingarelli; Vikas P Sukhatme; Samir M Parikh; Derek S Wheeler
Admission angiopoietin levels in children with septic shock.
Shock (Augusta, Ga.) 2007;28(6):650-654.
2007: Jennifer Kaplan; James A Cook; Michael O'Connor; Basilia Zingarelli
Peroxisome proliferator-activated receptor gamma is required for the inhibitory effect of ciglitazone but not 15-deoxy-Delta 12,14-prostaglandin J2 on the NFkappaB pathway in human endothelial cells.
Shock (Augusta, Ga.) 2007;28(6):722-726.
2007: Basilia Zingarelli; Paul W Hake; Prajakta Mangeshkar; Michael O'Connor; Timothy J Burroughs; Giovanna Piraino; Alvin Denenberg; Hector R Wong
Diverse cardioprotective signaling mechanisms of peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone, in reperfusion injury: role of nuclear factor-kappaB, heat shock factor 1, and Akt.
Shock (Augusta, Ga.) 2007;28(5):554-63.
2007: Ranjit S Chima; Basilia Zingarelli
Surfactant treatment of neonatal acute respiratory distress syndrome: is "fortification" the answer?
Critical care medicine 2007;35(10):2442-3.
2007: Derek S Wheeler; Patrick M Lahni; Paul W Hake; Alvin Denenberg; Hector R Wong; Connie Snead; John D Catravas; Basilia Zingarelli
The green tea polyphenol epigallocatechin-3-gallate improves systemic hemodynamics and survival in rodent models of polymicrobial sepsis.
Shock (Augusta, Ga.) 2007;28(3):353-9.
2007: Hongkuan Fan; David L Williams; Basilia Zingarelli; Kevin F Breuel; Giuseppe Teti; George E Tempel; Karsten Spicher; Guylain Boulay; Lutz Birnbaumer; Perry V Halushka; James A Cook
Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in macrophages by Galpha(i) proteins.
Immunology 2007;122(1):116-23.
2007: Michael G Vish; Prajakta Mangeshkar; Giovanna Piraino; Alvin Denenberg; Paul W Hake; Michael O'Connor; Basilia Zingarelli
Proinsulin c-peptide exerts beneficial effects in endotoxic shock in mice.
Critical care medicine 2007;35(5):1348-55.
2006: Hongkuan Fan; David L Williams; Basilia Zingarelli; Kevin F Breuel; Giuseppe Teti; George E Tempel; Karsten Spicher; Guylain Boulay; Lutz Birnbaumer; Perry V Halushka; James A Cook
Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in splenocytes by Galphai proteins.
Biochimica et biophysica acta 2006;1763(10):1051-8.
2006: Giovanna Piraino; James A Cook; Michael O'Connor; Paul W Hake; Timothy J Burroughs; Diana Teti; Basilia Zingarelli
Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages.
Shock (Augusta, Ga.) 2006;26(2):146-53.
2006: Octavia M Peck; Basilia Zingarelli; Hongkuan Fan; Giuseppe Teti; George E Tempel; Perry V Halushka; James A Cook
The phosphatidylinositol 3 kinase pathway regulates tolerance to lipopolysaccharide and priming responses to Staphylococcus aureus and lipopolysaccharide.
Shock (Augusta, Ga.) 2006;26(1):31-6.
2006: Basilia Zingarelli
Erythropoietin: a role in intensive care beyond erythropoiesis?
Critical care medicine 2006;34(4):1281-2.
2006: Hongkuan Fan; David L Williams; Kevin F Breuel; Basilia Zingarelli; Giuseppe Teti; George E Tempel; Perry V Halushka; James A Cook
Gi proteins regulate lipopolysaccharide and Staphylococcus aureus induced cytokine production but not (1--> 3)-beta-D-glucan induced cytokine suppression.
Frontiers in bioscience : a journal and virtual library 2006;11():2264-74.
2005: Basilia Zingarelli
Nuclear factor-kappaB.
Critical care medicine 2005;33(12 Suppl):S414-6.
2005: Tomohisa Okaya; John Blanchard; Rebecca Schuster; Satoshi Kuboki; Thomas L Husted; Charles C Caldwell; Basilia Zingarelli; Hector Wong; Joseph S Solomkin; Alex B Lentsch
Age-dependent responses to hepatic ischemia/reperfusion injury.
Shock (Augusta, Ga.) 2005;24(5):421-7.
2005: Hongkuan Fan; Basilia Zingarelli; Octavia M Peck; Giuseppe Teti; George E Tempel; Perry V Halushka; Karsten Spicher; Guylain Boulay; Lutz Birnbaumer; James A Cook
Lipopolysaccharide- and gram-positive bacteria-induced cellular inflammatory responses: role of heterotrimeric Galpha(i) proteins.
American journal of physiology. Cell physiology 2005;289(2):C293-301.
2005: Jennifer M Kaplan; James A Cook; Paul W Hake; Michael O'Connor; Timothy J Burroughs; Basilia Zingarelli
15-Deoxy-delta(12,14)-prostaglandin J(2) (15D-PGJ(2)), a peroxisome proliferator activated receptor gamma ligand, reduces tissue leukosequestration and mortality in endotoxic shock.
Shock (Augusta, Ga.) 2005;24(1):59-65.
2005: Basilia Zingarelli; James A Cook
Peroxisome proliferator-activated receptor-gamma is a new therapeutic target in sepsis and inflammation.
Shock (Augusta, Ga.) 2005;23(5):393-9.
2005: Jodie Y Duffy; Steven M Schwartz; Jefferson M Lyons; Jason H Bell; Connie J Wagner; Basilia Zingarelli; Jeffrey M Pearl
Calpain inhibition decreases endothelin-1 levels and pulmonary hypertension after cardiopulmonary bypass with deep hypothermic circulatory arrest.
Critical care medicine 2005;33(3):623-8.
2005: Jennifer Kaplan; Michael O'Connor; Paul W Hake; Basilia Zingarelli
Inhibitors of poly (ADP-ribose) polymerase ameliorate myocardial reperfusion injury by modulation of activator protein-1 and neutrophil infiltration.
Shock (Augusta, Ga.) 2005;23(3):233-8.
2005: Santosh G Dixit; Basilia Zingarelli; Donna J Buckley; Arthur R Buckley; Giovanni M Pauletti
Nitric oxide mediates increased P-glycoprotein activity in interferon-{gamma}-stimulated human intestinal cells.
American journal of physiology. Gastrointestinal and liver physiology 2005;288(3):G533-40.
2005: Jose Irazuzta; Robert K Pretzlaff; Gabrielle DeCourten-Myers; Frank P Zemlan; Basilia Zingarelli
Dexamethasone decreases neurological sequelae and caspase activity.
Intensive care medicine 2005;31(1):146-50.
2004: Basilia Zingarelli; Paul W Hake; Timothy J Burroughs; Giovanna Piraino; Michael O'Connor; Alvin Denenberg
Activator protein-1 signalling pathway and apoptosis are modulated by poly(ADP-ribose) polymerase-1 in experimental colitis.
Immunology 2004;113(4):509-17.
2004: Basilia Zingarelli
Ethyl pyruvate: a simple solution?
Critical care medicine 2004;32(7):1603-4.
2004: Basilia Zingarelli; Paul W Hake; Michael O'Connor; Alvin Denenberg; Hector R Wong; Sue Kong; Bruce Aronow
Differential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1.
American journal of physiology. Heart and circulatory physiology 2004;286(4):H1408-15.
2004: Basilia Zingarelli
Peptidoglycan is an important pathogenic factor of the inflammatory response in sepsis.
Critical care medicine 2004;32(2):613-4.
2004: Rajesh Aneja; Paul W Hake; Timothy J Burroughs; Alvin Denenberg; Hector R Wong; Basilia Zingarelli
Epigallocatechin, a green tea polyphenol, attenuates myocardial ischemia reperfusion injury in rats.
Molecular medicine (Cambridge, Mass.) 2004;10(1-6):55-62.
2003: Basilia Zingarelli; Maeve Sheehan; Paul W Hake; Michael O'Connor; Alvin Denenberg; James A Cook
Peroxisome proliferator activator receptor-gamma ligands, 15-deoxy-Delta(12,14)-prostaglandin J2 and ciglitazone, reduce systemic inflammation in polymicrobial sepsis by modulation of signal transduction pathways.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(12):6827-37.
2003: Maeve Sheehan; Hector R Wong; Paul W Hake; Basilia Zingarelli
Parthenolide improves systemic hemodynamics and decreases tissue leukosequestration in rats with polymicrobial sepsis.
Critical care medicine 2003;31(9):2263-70.
2003: Kelly Guyton; Basilia Zingarelli; Sarah Ashton; Giuseppe Teti; George E Tempel; Chris Reilly; Gary S Gilkeson; Perry V Halushka; James A Cook
Peroxisome proliferator-activated receptor-gamma agonists modulate macrophage activation by gram-negative and gram-positive bacterial stimuli.
Shock (Augusta, Ga.) 2003;20(1):56-62.
2003: Basilia Zingarelli; Michael O'Connor; Paul W Hake
Inhibitors of poly (ADP-ribose) polymerase modulate signal transduction pathways in colitis.
European journal of pharmacology 2003;469(1-3):183-94.
2003: Basilia Zingarelli; Paul W Hake; Michael O'Connor; Alvin Denenberg; Sue Kong; Bruce Aronow
Absence of poly(ADP-ribose)polymerase-1 alters nuclear factor-kappa B activation and gene expression of apoptosis regulators after reperfusion injury.
Molecular medicine (Cambridge, Mass.) 2003;9(5-8):143-53.
2003: Teresa L Andreone; Michael O'Connor; Alvin Denenberg; Paul W Hake; Basilia Zingarelli
Poly(ADP-ribose) polymerase-1 regulates activation of activator protein-1 in murine fibroblasts.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(4):2113-20.
2003: Susan A McDowell; Kelly Gammon; Basilia Zingarelli; Cindy J Bachurski; Bruce Aronow; Daniel R Prows; George Leikauf
Inhibition of nitric oxide restores surfactant gene expression following nickel-induced acute lung injury.
American journal of respiratory cell and molecular biology 2003;28(2):188-98.
2003: Basilia Zingarelli; Maeve Sheehan; Hector R Wong
Nuclear factor-kappaB as a therapeutic target in critical care medicine.
Critical care medicine 2003;31(1 Suppl):S105-11.
2002: Jose Irazuzta; Robert K Pretzlaff; Basilia Zingarelli; Vivian Xue; Frank P Zemlan
Modulation of nuclear factor-kappaB activation and decreased markers of neurological injury associated with hypothermic therapy in experimental bacterial meningitis.
Critical care medicine 2002;30(11):2553-9.
2002: Basilia Zingarelli; Paul W Hake; James A Cook
Inducible nitric oxide synthase is not required in the development of endotoxin tolerance in mice.
Shock (Augusta, Ga.) 2002;17(6):478-84.
2002: Maeve Sheehan; Hector R Wong; Paul W Hake; Vivek Malhotra; Michael O'Connor; Basilia Zingarelli
Parthenolide, an inhibitor of the nuclear factor-kappaB pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodents.
Molecular pharmacology 2002;61(5):953-63.
2002: Basilia Zingarelli; Paul W Hake; Zequan Yang; Michael O'Connor; Alvin Denenberg; Hector R Wong
Absence of inducible nitric oxide synthase modulates early reperfusion-induced NF-kappaB and AP-1 activation and enhances myocardial damage.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(3):327-42.
2002: Basilia Zingarelli; Paul W Hake; Alvin Denenberg; Hector R Wong
Sesquiterpene lactone parthenolide, an inhibitor of IkappaB kinase complex and nuclear factor-kappaB, exerts beneficial effects in myocardial reperfusion injury.
Shock (Augusta, Ga.) 2002;17(2):127-34.
2002: Maeve Sheehan; Hector R Wong; Paul W Hake; Basilia Zingarelli
Protective effects of isohelenin, an inhibitor of nuclear factor kappaB, in endotoxic shock in rats.
Journal of endotoxin research 2002;8(2):99-107.
2001: Basilia Zingarelli; Zequan Yang; Paul W Hake; Alvin Denenberg; Hector R Wong
Absence of endogenous interleukin 10 enhances early stress response during post-ischaemic injury in mice intestine.
Gut 2001;48(5):610-22.
2000: Jose Irazuzta; Robert K Pretzlaff; ME Rowin; K Milam; Frank P Zemlan; Basilia Zingarelli
Hypothermia as an adjunctive treatment for severe bacterial meningitis.
Brain research 2000;881(1):88-97.
2000: L Liaudet; A Szabó; Francisco Soriano; Basilia Zingarelli; Csaba Szabó; Andrew L Salzman
Poly (ADP-ribose) synthetase mediates intestinal mucosal barrier dysfunction after mesenteric ischemia.
Shock (Augusta, Ga.) 2000;14(2):134-41.
2000: Brian R Jacobs; DJ Smith; Basilia Zingarelli; DJ Passerini; Edgar T Ballard; Richard J Brilli
Soluble nitric oxide donor and surfactant improve oxygenation and pulmonary hypertension in porcine lung injury.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2000;4(4):412-22.
2000: Jose Irazuzta; L D Mirkin; Basilia Zingarelli
Mercaptoethylguanidine attenuates inflammation in bacterial meningitis in rabbits.
Life sciences 2000;67(4):365-72.
2000: Basilia Zingarelli; Gwen S Scott; Paul W Hake; Andrew L Salzman; Csaba Szabó
Effects of nicaraven on nitric oxide-related pathways and in shock and inflammation.
Shock (Augusta, Ga.) 2000;13(2):126-34.
2000: Z Yang; Basilia Zingarelli; Csaba Szabó
Effect of genetic disruption of poly (ADP-ribose) synthetase on delayed production of inflammatory mediators and delayed necrosis during myocardial ischemia-reperfusion injury.
Shock (Augusta, Ga.) 2000;13(1):60-6.
1999: Yoram Stern; Andrew L Salzman; Robin T Cotton; Basilia Zingarelli
Protective effect of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase, against laryngeal injury in rats.
American journal of respiratory and critical care medicine 1999;160(5 Pt 1):1743-9.
1999: Basilia Zingarelli; György Haskó; Andrew L Salzman; Csaba Szabó
Effects of a novel guanylyl cyclase inhibitor on the vascular actions of nitric oxide and peroxynitrite in immunostimulated smooth muscle cells and in endotoxic shock.
Critical care medicine 1999;27(9):1701-7.
1998: Basilia Zingarelli; A L Salzman; Csaba Szabó
Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury.
Circulation research 1998;83(1):85-94.
1998: E Gilad; Hector R Wong; Basilia Zingarelli; Laszlo Virag; Michael O'Connor; Andrew L Salzman; Csaba Szabó
Melatonin inhibits expression of the inducible isoform of nitric oxide synthase in murine macrophages: role of inhibition of NFkappaB activation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(9):685-93.
1998: Basilia Zingarelli; Laszlo Virag; A Szabó; S Cuzzocrea; Andrew L Salzman; Csaba Szabó
Oxidation, tyrosine nitration and cytostasis induction in the absence of inducible nitric oxide synthase.
International journal of molecular medicine 1998;1(5):787-95.
1998: Csaba Szabó; Laszlo Virag; S Cuzzocrea; Gwen S Scott; Paul W Hake; M P O'Connor; Basilia Zingarelli; Andrew L Salzman; E Kun
Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3867-72.
1998: S Cuzzocrea; Basilia Zingarelli; Michael O'Connor; Andrew L Salzman; Csaba Szabó
Effect of L-buthionine-(S,R)-sulphoximine, an inhibitor of gamma-glutamylcysteine synthetase on peroxynitrite- and endotoxic shock-induced vascular failure.
British journal of pharmacology 1998;123(3):525-37.
1998: S Cuzzocrea; Basilia Zingarelli; Paul W Hake; Andrew L Salzman; Csaba Szabó
Antiinflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation.
Free radical biology & medicine 1998;24(3):450-9.
1998: S Cuzzocrea; Basilia Zingarelli; E Gilad; Paul W Hake; Andrew L Salzman; Csaba Szabó
Protective effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthase in a carrageenan-induced model of local inflammation.
European journal of pharmacology 1998;342(1):67-76.
1997: S Cuzzocrea; A Tailor; Basilia Zingarelli; Andrew L Salzman; R J Flower; Csaba Szabó; M Perretti
Lipocortin 1 protects against splanchnic artery occlusion and reperfusion injury by affecting neutrophil migration.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(10):5089-97.
1997: Basilia Zingarelli; S Cuzzocrea; Zsuzsanna Zsengellér; Andrew L Salzman; Csaba Szabó
Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase.
Cardiovascular research 1997;36(2):205-15.
1997: Basilia Zingarelli; H Ischiropoulos; Andrew L Salzman; Csaba Szabó
Amelioration by mercaptoethylguanidine of the vascular and energetic failure in haemorrhagic shock in the anesthetised rat.
European journal of pharmacology 1997;338(1):55-65.
1997: Csaba Szabó; Lina Lim; S Cuzzocrea; S J Getting; Basilia Zingarelli; R J Flower; Andrew L Salzman; M Perretti
Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects.
The Journal of experimental medicine 1997;186(7):1041-9.
1997: S Cuzzocrea; Basilia Zingarelli; E Gilad; Paul W Hake; Andrew L Salzman; Csaba Szabó
Protective effect of melatonin in carrageenan-induced models of local inflammation: relationship to its inhibitory effect on nitric oxide production and its peroxynitrite scavenging activity.
Journal of pineal research 1997;23(2):106-16.
1997: E Gilad; Basilia Zingarelli; Andrew L Salzman; Csaba Szabó
Protection by inhibition of poly (ADP-ribose) synthetase against oxidant injury in cardiac myoblasts In vitro.
Journal of molecular and cellular cardiology 1997;29(9):2585-97.
1997: Basilia Zingarelli; G J Southan; E Gilad; Michael O'Connor; Andrew L Salzman; Csaba Szabó
The inhibitory effects of mercaptoalkylguanidines on cyclo-oxygenase activity.
British journal of pharmacology 1997;120(3):357-66.
1997: Basilia Zingarelli; Brian Day; J D Crapo; Andrew L Salzman; Csaba Szabó
The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock.
British journal of pharmacology 1997;120(2):259-67.
1997: E Gilad; S Cuzzocrea; Basilia Zingarelli; Andrew L Salzman; Csaba Szabó
Melatonin is a scavenger of peroxynitrite.
Life sciences 1997;60(10):PL169-74.
1997: Csaba Szabó; György Haskó; Basilia Zingarelli; Z H Németh; Andrew L Salzman; Vladimir Kvetan; Stephen M Pastores; E S Vizi
Isoproterenol regulates tumour necrosis factor, interleukin-10, interleukin-6 and nitric oxide production and protects against the development of vascular hyporeactivity in endotoxaemia.
Immunology 1997;90(1):95-100.
1996: Csaba Szabó; R Bryk; Basilia Zingarelli; G J Southan; T C Gahman; V Bhat; Andrew L Salzman; Donald J Wolff
Pharmacological characterization of guanidinoethyldisulphide (GED), a novel inhibitor of nitric oxide synthase with selectivity towards the inducible isoform.
British journal of pharmacology 1996;118(7):1659-68.
1996: Csaba Szabó; Basilia Zingarelli; M O'Connor; Andrew L Salzman
DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(5):1753-8.
1996: G J Southan; Basilia Zingarelli; Michael O'Connor; Andrew L Salzman; Csaba Szabó
Spontaneous rearrangement of aminoalkylisothioureas into mercaptoalkylguanidines, a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform.
British journal of pharmacology 1996;117(4):619-32.
1996: Basilia Zingarelli; M O'Connor; H Wong; Andrew L Salzman; Csaba Szabó
Peroxynitrite-mediated DNA strand breakage activates poly-adenosine diphosphate ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(1):350-8.