Rolf Zinkernagel

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Lymphocytic Choriomeningitis

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Navarini Alexander A; Lang Karl S; Verschoor Admar; Recher Mike; Zinkernagel Annelies S; Nizet Victor; Odermatt Bernhard; Hengartner Hans; Zinkernagel Rolf M
Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections.
Geuking Markus B; Weber Jacqueline; Dewannieux Marie; Gorelik Elieser; Heidmann Thierry; Hengartner Hans; Zinkernagel Rolf M; Hangartner Lars
Recombination of retrotransposon and exogenous RNA virus results in nonretroviral cDNA integration.
McCoy Kathy D; Stoel Maaike; Stettler Rebecca; Merky Patrick; Fink Katja; Senn Beatrice M; Schaer Corinne; Massacand Joanna; Odermatt Bernhard; Oettgen Hans C; Zinkernagel Rolf M; Bos Nicolaas A; Hengartner Hans; Macpherson Andrew J; Harris Nicola L
Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection.

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2009: Navarini Alexander A; Lang Karl S; Verschoor Admar; Recher Mike; Zinkernagel Annelies S; Nizet Victor; Odermatt Bernhard; Hengartner Hans; Zinkernagel Rolf M
Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(17):7107-12.
2009: Geuking Markus B; Weber Jacqueline; Dewannieux Marie; Gorelik Elieser; Heidmann Thierry; Hengartner Hans; Zinkernagel Rolf M; Hangartner Lars
Recombination of retrotransposon and exogenous RNA virus results in nonretroviral cDNA integration.
Science (New York, N.Y.) 2009;323(5912):393-6.
2008: McCoy Kathy D; Stoel Maaike; Stettler Rebecca; Merky Patrick; Fink Katja; Senn Beatrice M; Schaer Corinne; Massacand Joanna; Odermatt Bernhard; Oettgen Hans C; Zinkernagel Rolf M; Bos Nicolaas A; Hengartner Hans; Macpherson Andrew J; Harris Nicola L
Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection.
Cell host & microbe 2008;4(4):362-73.
2008: Lang Philipp A; Contaldo Claudio; Georgiev Panco; El-Badry Ashraf Mohammad; Recher Mike; Kurrer Michael; Cervantes-Barragan Luisa; Ludewig Burkhard; Calzascia Thomas; Bolinger Beatrice; Merkler Doron; Odermatt Bernhard; Bader Michael; Graf Rolf; Clavien Pierre-Alain; Hegazy Ahmed N; Löhning Max; Harris Nicola L; Ohashi Pamela S; Hengartner Hans; Zinkernagel Rolf M; Lang Karl S
Aggravation of viral hepatitis by platelet-derived serotonin.
Nature medicine 2008;14(7):756-61.
2008: Kranich Jan; Krautler Nike Julia; Heinen Ernst; Polymenidou Magdalini; Bridel Claire; Schildknecht Anita; Huber Christoph; Kosco-Vilbois Marie H; Zinkernagel Rolf; Miele Gino; Aguzzi Adriano
Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8.
The Journal of experimental medicine 2008;205(6):1293-302.
2008: Löhning Max; Hegazy Ahmed N; Pinschewer Daniel D; Busse Dorothea; Lang Karl S; Höfer Thomas; Radbruch Andreas; Zinkernagel Rolf M; Hengartner Hans
Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors.
The Journal of experimental medicine 2008;205(1):53-61.
2008: Fink Katja; Zellweger Raphael; Weber Jacqueline; Manjarrez-Orduno Nataly; Holdener Martin; Senn Beatrice M; Hengartner Hans; Zinkernagel Rolf M; Macpherson Andrew J
Long-term maternal imprinting of the specific B cell repertoire by maternal antibodies.
European journal of immunology 2008;38(1):90-101.
2007: Recher Mike; Lang Karl S; Navarini Alexander; Hunziker Lukas; Lang Philipp A; Fink Katja; Freigang Stefan; Georgiev Panco; Hangartner Lars; Zellweger Raphael; Bergthaler Andreas; Hegazy Ahmed N; Eschli Bruno; Theocharides Alexandre; Jeker Lukas T; Merkler Doron; Odermatt Bernhard; Hersberger Martin; Hengartner Hans; Zinkernagel Rolf M
Extralymphatic virus sanctuaries as a consequence of potent T-cell activation.
Nature medicine 2007;13(11):1316-23.
2007: Fink Katja; Manjarrez-Orduño Nataly; Schildknecht Anita; Weber Jacqueline; Senn Beatrice M; Zinkernagel Rolf M; Hengartner Hans
B cell activation state-governed formation of germinal centers following viral infection.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(9):5877-85.
2007: Eschli Bruno; Zellweger Raphaël M; Wepf Alexander; Lang Karl S; Quirin Katharina; Weber Jacqueline; Zinkernagel Rolf M; Hengartner Hans
Early antibodies specific for the neutralizing epitope on the receptor binding subunit of the lymphocytic choriomeningitis virus glycoprotein fail to neutralize the virus.
Journal of virology 2007;81(21):11650-7.
2007: Lang Karl S; Navarini Alexander A; Recher Mike; Lang Philipp A; Heikenwalder Mathias; Stecher Barbara; Bergthaler Andreas; Odermatt Bernhard; Akira Shizuo; Honda Kenya; Hengartner Hans; Zinkernagel Rolf M
MyD88 protects from lethal encephalitis during infection with vesicular stomatitis virus.
European journal of immunology 2007;37(9):2434-40.
2007: Freigang Stefan; Eschli Bruno; Harris Nicola; Geuking Markus; Quirin Katharina; Schrempf Sabrina; Zellweger Raphael; Weber Jacqueline; Hengartner Hans; Zinkernagel Rolf M
A lymphocytic choriomeningitis virus glycoprotein variant that is retained in the endoplasmic reticulum efficiently cross-primes CD8(+) T cell responses.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(33):13426-31.
2007: Pochanke Veronika; Koller Samuel; Dayer Régine; Hatak Sarah; Ludewig Burkhard; Zinkernagel Rolf M; Hengartner Hans; McCoy Kathy D
Identification and characterization of a novel antigen from the nematode Nippostrongylus brasiliensis recognized by specific IgE.
European journal of immunology 2007;37(5):1275-84.
2007: Zinkernagel Rolf
On observing and analyzing disease versus signals.
Nature immunology 2007;8(1):8-10.
2007: Brent L; Cohen I R; Doherty P C; Feldmann M; Matzinger P; Ghost Lab; Holgate S T; Lachmann P; Mitchison N A; Nossal G; Rose N R; Zinkernagel R
Crystal-ball gazing--the future of immunological research viewed from the cutting edge.
Clinical and experimental immunology 2007;147(1):1-10.
2007: Zinkernagel Rolf M
Science and sensibility: an interview with Professor Rolf M. Zinkernagel, Nobel Prize Winner for Medicine 1996. Interview by Hrishikesh Satish Kulkarni and Ajit H. Goenka.
MedGenMed : Medscape general medicine 2007;9(4):28.
2007: Lang Karl S; Hegazy Ahmed N; Lang Philipp A; Eschli Bruno; Löhning Max; Hengartner Hans; Zinkernagel Rolf M; Recher Mike
"Negative vaccination" by specific CD4 T cell tolerisation enhances virus-specific protective antibody responses.
PloS one 2007;2(11):e1162.
2007: Lötscher Marius; Recher Mike; Lang Karl S; Navarini Alexander; Hunziker Lukas; Santimaria Roger; Glatzel Markus; Schwarz Petra; Böni Jürg; Zinkernagel Rolf M
Induced prion protein controls immune-activated retroviruses in the mouse spleen.
PloS one 2007;2(11):e1158.
2006: Zellweger Raphaël M; Hangartner Lars; Weber Jacqueline; Zinkernagel Rolf M; Hengartner Hans
Parameters governing exhaustion of rare T cell-independent neutralizing IgM-producing B cells after LCMV infection.
European journal of immunology 2006;36(12):3175-85.
2006: Harris Nicola L; Spoerri Iris; Schopfer Jacqueline F; Nembrini Chiara; Merky Patrick; Massacand Joanna; Urban Joseph F; Lamarre Alain; Burki Kurt; Odermatt Bernhard; Zinkernagel Rolf M; Macpherson Andrew J
Mechanisms of neonatal mucosal antibody protection.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):6256-62.
2006: Navarini Alexander A; Recher Mike; Lang Karl S; Georgiev Panco; Meury Susanne; Bergthaler Andreas; Flatz Lukas; Bille Jacques; Landmann Regine; Odermatt Bernhard; Hengartner Hans; Zinkernagel Rolf M
Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(42):15535-9.
2006: Martinic Marianne M; van den Broek Maries F; Rülicke Thomas; Huber Christoph; Odermatt Bernhard; Reith Walter; Horvath Edit; Zellweger Raphael; Fink Katja; Recher Mike; Eschli Bruno; Hengartner Hans; Zinkernagel Rolf M
Functional CD8+ but not CD4+ T cell responses develop independent of thymic epithelial MHC.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(39):14435-40.
2006: Lang Karl S; Georgiev Panco; Recher Mike; Navarini Alexander A; Bergthaler Andreas; Heikenwalder Mathias; Harris Nicola L; Junt Tobias; Odermatt Bernhard; Clavien Pierre-Alain; Pircher Hanspeter; Akira Shizuo; Hengartner Hans; Zinkernagel Rolf M
Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling.
The Journal of clinical investigation 2006;116(9):2456-63.
2006: Pochanke Veronika; Hatak Sarah; Hengartner Hans; Zinkernagel Rolf M; McCoy Kathy D
Induction of IgE and allergic-type responses in fur mite-infested mice.
European journal of immunology 2006;36(9):2434-45.
2006: Hangartner Lars; Zellweger Raphaël M; Giobbi Mattia; Weber Jacqueline; Eschli Bruno; McCoy Kathy D; Harris Nicola; Recher Mike; Zinkernagel Rolf M; Hengartner Hans
Nonneutralizing antibodies binding to the surface glycoprotein of lymphocytic choriomeningitis virus reduce early virus spread.
The Journal of experimental medicine 2006;203(8):2033-42.
2006: Junt Tobias; Tumanov Alexei V; Harris Nicola; Heikenwalder Mathias; Zeller Nicolas; Kuprash Dmitry V; Aguzzi Adriano; Ludewig Burkhard; Nedospasov Sergei A; Zinkernagel Rolf M
Expression of lymphotoxin beta governs immunity at two distinct levels.
European journal of immunology 2006;36(8):2061-75.
2006: Fink Katja; Lang Karl S; Manjarrez-Orduno Nataly; Junt Tobias; Senn Beatrice M; Holdener Martin; Akira Shizuo; Zinkernagel Rolf M; Hengartner Hans
Early type I interferon-mediated signals on B cells specifically enhance antiviral humoral responses.
European journal of immunology 2006;36(8):2094-105.
2006: Zinkernagel Rolf M; Hengartner Hans
Protective 'immunity' by pre-existent neutralizing antibody titers and preactivated T cells but not by so-called 'immunological memory'.
Immunological reviews 2006;211():310-9.
2006: Eschli Bruno; Quirin Katharina; Wepf Alexander; Weber Jacqueline; Zinkernagel Rolf; Hengartner Hans
Identification of an N-terminal trimeric coiled-coil core within arenavirus glycoprotein 2 permits assignment to class I viral fusion proteins.
Journal of virology 2006;80(12):5897-907.
2006: Merkler Doron; Horvath Edit; Bruck Wolfgang; Zinkernagel Rolf M; Del la Torre Juan Carlos; Pinschewer Daniel D
"Viral déjà vu" elicits organ-specific immune disease independent of reactivity to self.
The Journal of clinical investigation 2006;116(5):1254-63.
2006: McCoy Kathy D; Harris Nicola L; Diener Philipp; Hatak Sarah; Odermatt Bernhard; Hangartner Lars; Senn Beatrice M; Marsland Benjamin J; Geuking Markus B; Hengartner Hans; Macpherson Andrew J S; Zinkernagel Rolf M
Natural IgE production in the absence of MHC Class II cognate help.
Immunity 2006;24(3):329-39.
2006: Hangartner Lars; Zinkernagel Rolf M; Hengartner Hans
Antiviral antibody responses: the two extremes of a wide spectrum.
Nature reviews. Immunology 2006;6(3):231-43.
2006: Bonilla Weldy V; Geuking Markus B; Aichele Peter; Ludewig Burkhard; Hengartner Hans; Zinkernagel Rolf M
Microchimerism maintains deletion of the donor cell-specific CD8+ T cell repertoire.
The Journal of clinical investigation 2006;116(1):156-62.
2005: Junt Tobias; Fink Katja; Förster Reinhold; Senn Beatrice; Lipp Martin; Muramatsu Masamichi; Zinkernagel Rolf M; Ludewig Burkhard; Hengartner Hans
CXCR5-dependent seeding of follicular niches by B and Th cells augments antiviral B cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(11):7109-16.
2005: Lang Karl S; Recher Mike; Navarini Alexander A; Freigang Stefan; Harris Nicola L; van den Broek Maries; Odermatt Bernhard; Hengartner Hans; Zinkernagel Rolf M
Requirement for neutralizing antibodies to control bone marrow transplantation-associated persistent viral infection and to reduce immunopathology.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(8):5524-31.
2005: Zinkernagel R; Hengartner H
Responses to Cohn's discussion on the Zinkernagel-Hengartner 'Credo 2004'.
Scandinavian journal of immunology 2005;62(3):195-201.
2005: Probst H C; Tschannen K; Odermatt B; Schwendener R; Zinkernagel R M; Van Den Broek M
Histological analysis of CD11c-DTR/GFP mice after in vivo depletion of dendritic cells.
Clinical and experimental immunology 2005;141(3):398-404.
2005: Lang Karl S; Recher Mike; Navarini Alexander A; Harris Nicola L; Löhning Max; Junt Tobias; Probst Hans Christian; Hengartner Hans; Zinkernagel Rolf M
Inverse correlation between IL-7 receptor expression and CD8 T cell exhaustion during persistent antigen stimulation.
European journal of immunology 2005;35(3):738-45.
2005: Lang Karl S; Recher Mike; Junt Tobias; Navarini Alexander A; Harris Nicola L; Freigang Stefan; Odermatt Bernhard; Conrad Curdin; Ittner Lars M; Bauer Stefan; Luther Sanjiv A; Uematsu Satoshi; Akira Shizuo; Hengartner Hans; Zinkernagel Rolf M
Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease.
Nature medicine 2005;11(2):138-45.
2004: Pinschewer Daniel D; Perez Mar; Jeetendra Eswaraka; Bächi Thomas; Horvath Edit; Hengartner Hans; Whitt Michael A; de la Torre Juan Carlos; Zinkernagel Rolf M
Kinetics of protective antibodies are determined by the viral surface antigen.
The Journal of clinical investigation 2004;114(7):988-93.
2004: Recher Mike; Lang Karl S; Hunziker Lukas; Freigang Stefan; Eschli Bruno; Harris Nicola L; Navarini Alexander; Senn Beatrice M; Fink Katja; Lötscher Marius; Hangartner Lars; Zellweger Raphaël; Hersberger Martin; Theocharides Alexandre; Hengartner Hans; Zinkernagel Rolf M
Deliberate removal of T cell help improves virus-neutralizing antibody production.
Nature immunology 2004;5(9):934-42.
2004: Zinkernagel Rolf M
On 'reactivity' versus 'tolerance'.
Immunology and cell biology 2004;82(4):343-52.
2004: Zinkernagel R M; Hengartner H
On immunity against infections and vaccines: credo 2004.
Scandinavian journal of immunology 2004;60(1-2):9-13.
2004: Blais Marie-Eve; Gérard Gwladys; Martinic Marianne M; Roy-Proulx Guillaume; Zinkernagel Rolf M; Perreault Claude
Do thymically and strictly extrathymically developing T cells generate similar immune responses?
Blood 2004;103(8):3102-10.
2004: Martinic Marianne M; Rocha Benedita; McCoy Kathy D; Hengartner Hans; Zinkernagel Rolf M
Role of TCR-restricting MHC density and thymic environment on selection and survival of cells expressing low-affinity T cell receptors.
European journal of immunology 2004;34(4):1041-9.
2004: Zinkernagel Rolf M
The challenges of an HIV vaccine enterprise.
Science (New York, N.Y.) 2004;303(5662):1294-7; author reply 1294-7.
2004: Bachmann Martin F; Hunziker Lukas; Zinkernagel Rolf M; Storni Tazio; Kopf Manfred
Maintenance of memory CTL responses by T helper cells and CD40-CD40 ligand: antibodies provide the key.
European journal of immunology 2004;34(2):317-26.
2004: Heikenwalder Mathias; Polymenidou Magdalini; Junt Tobias; Sigurdson Christina; Wagner Hermann; Akira Shizuo; Zinkernagel Rolf; Aguzzi Adriano
Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration.
Nature medicine 2004;10(2):187-92.
2003: Planz Oliver; Seiler Peter; Hengartner Hans; Zinkernagel Rolf M
Specific cytotoxic T cells eliminate cells producing neutralizing antibodies.
Nature 2003;426(6965):474.
2003: Freigang Stefan; Egger Denise; Bienz Kurt; Hengartner Hans; Zinkernagel Rolf M
Endogenous neosynthesis vs. cross-presentation of viral antigens for cytotoxic T cell priming.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(23):13477-82.
2003: Hangartner Lars; Senn Beatrice M; Ledermann Birgit; Kalinke Ulrich; Seiler Peter; Bucher Etienne; Zellweger Raphaël M; Fink Katja; Odermatt Bernhard; Bürki Kurt; Zinkernagel Rolf M; Hengartner Hans
Antiviral immune responses in gene-targeted mice expressing the immunoglobulin heavy chain of virus-neutralizing antibodies.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(22):12883-8.
2003: Kadry Zakiyah; Mullhaupt Beat; Renner Eberhard L; Bauerfeind Peter; Schanz Urs; Pestalozzi Bernhard C; Studer Gabriella; Zinkernagel Rolf; Clavien Pierre-Alain
Living donor liver transplantation and tolerance: a potential strategy in cholangiocarcinoma.
Transplantation 2003;76(6):1003-6.
2003: Hunziker Lukas; Ciurea Adrian; Recher Mike; Hengartner Hans; Zinkernagel Rolf M
Public versus personal serotypes of a viral quasispecies.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):6015-20.
2003: Senn Beatrice M; López-Macías Constantino; Kalinke Ulrich; Lamarre Alain; Isibasi Armando; Zinkernagel Rolf M; Hengartner Hans
Combinatorial immunoglobulin light chain variability creates sufficient B cell diversity to mount protective antibody responses against pathogen infections.
European journal of immunology 2003;33(4):950-61.
2003: Hunziker Lukas; Recher Mike; Macpherson Andrew J; Ciurea Adrian; Freigang Stefan; Hengartner Hans; Zinkernagel Rolf M
Hypergammaglobulinemia and autoantibody induction mechanisms in viral infections.
Nature immunology 2003;4(4):343-9.
2003: Martinic Marianne M; Rülicke Thomas; Althage Alana; Odermatt Bernhard; Höchli Matthias; Lamarre Alain; Dumrese Tilman; Speiser Daniel E; Kyburz Diego; Hengartner Hans; Zinkernagel Rolf M
Efficient T cell repertoire selection in tetraparental chimeric mice independent of thymic epithelial MHC.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1861-6.
2003: Zinkernagel Rolf M
On natural and artificial vaccinations.
Annual review of immunology 2003;21():515-46.
2002: Hunziker Lukas; Recher Mike; Ciurea Adrian; Martinic Marianne M A; Odermatt Bernhard; Hengartner Hans; Zinkernagel Rolf M
Antagonistic variant virus prevents wild-type virus-induced lethal immunopathology.
The Journal of experimental medicine 2002;196(8):1039-46.
2002: Zinkernagel Rolf M
On cross-priming of MHC class I-specific CTL: rule or exception?
European journal of immunology 2002;32(9):2385-92.
2002: Oehen Stephan; Odermatt Bernhard; Karrer Urs; Hengartner Hans; Zinkernagel Rolf; López-Macías Constantino
Marginal zone macrophages and immune responses against viruses.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(3):1453-8.
2002: Zinkernagel Rolf M
On differences between immunity and immunological memory.
Current opinion in immunology 2002;14(4):523-36.
2002: Zinkernagel Rolf M
Uncertainties - discrepancies in immunology.
Immunological reviews 2002;185():103-25.
2002: Pericin Marcus; Althage Alana; Freigang Stefan; Hengartner Hans; Rolland Eric; Dupraz Philippe; Thorens Bernard; Aebischer Patrick; Zinkernagel Rolf M
Allogeneic beta-islet cells correct diabetes and resist immune rejection.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(12):8203-6.
2002: Junt Tobias; Nakano Hideki; Dumrese Tilman; Kakiuchi Terutaka; Odermatt Bernhard; Zinkernagel Rolf M; Hengartner Hans; Ludewig Burkhard
Antiviral immune responses in the absence of organized lymphoid T cell zones in plt/plt mice.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6032-40.
2002: Ludewig Burkhard; Zinkernagel Rolf M; Hengartner Hans
Arterial inflammation and atherosclerosis.
Trends in cardiovascular medicine 2002;12(4):154-9.
2002: Zinkernagel Rolf M
Immunity, immunopathology and vaccines against HIV?
Vaccine 2002;20(15):1913-7.
2002: Zinkernagel Rolf M
Antiinfection immunity and autoimmunity.
Annals of the New York Academy of Sciences 2002;958():3-6.
2002: Bonilla Weldy V; Pinschewer Daniel D; Klenerman Paul; Rousson Valentin; Gaboli Mirella; Pandolfi Pier P; Zinkernagel Rolf M; Salvato Maria S; Hengartner Hans
Effects of promyelocytic leukemia protein on virus-host balance.
Journal of virology 2002;76(8):3810-8.
2002: Zinkernagel Rolf
Novartis Prizes for Immunology 2001, Stockholm.
Scandinavian journal of immunology 2002;55(3):220.
2002: Müller Stefan; Hunziker Lukas; Enzler Susanne; Bühler-Jungo Myriam; Di Santo James P; Zinkernagel Rolf M; Mueller Christoph
Role of an intact splenic microarchitecture in early lymphocytic choriomeningitis virus production.
Journal of virology 2002;76(5):2375-83.
2002: Hunziker Lukas; Klenerman Paul; Zinkernagel Rolf M; Ehl Stephan
Exhaustion of cytotoxic T cells during adoptive immunotherapy of virus carrier mice can be prevented by B cells or CD4+ T cells.
European journal of immunology 2002;32(2):374-82.
2002: Zinkernagel R M
Lymphocytic choriomeningitis virus and immunology.
Current topics in microbiology and immunology 2002;263():1-5.
2001: Starzl T E; Zinkernagel R M
Transplantation tolerance from a historical perspective.
Nature reviews. Immunology 2001;1(3):233-9.
2001: Ludewig B; Junt T; Hengartner H; Zinkernagel R M
Dendritic cells in autoimmune diseases.
Current opinion in immunology 2001;13(6):657-62.
2001: Zinkernagel R M
Maternal antibodies, childhood infections, and autoimmune diseases.
The New England journal of medicine 2001;345(18):1331-5.
2001: Heppner F L; Musahl C; Arrighi I; Klein M A; Rülicke T; Oesch B; Zinkernagel R M; Kalinke U; Aguzzi A
Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies.
Science (New York, N.Y.) 2001;294(5540):178-82.
2001: Pinschewer D D; Ochsenbein A F; Fehr T; Zinkernagel R M
Leflunomide-mediated suppression of antiviral antibody and Tcell responses: differential restoration by uridine.
Transplantation 2001;72(4):712-9.
2001: Zinkernagel R M; Hengartner H
Regulation of the immune response by antigen.
Science (New York, N.Y.) 2001;293(5528):251-3.
2001: Ciurea A; Hunziker L; Martinic M M; Oxenius A; Hengartner H; Zinkernagel R M
CD4+ T-cell-epitope escape mutant virus selected in vivo.
Nature medicine 2001;7(7):795-800.
2001: Macpherson A J; Lamarre A; McCoy K; Harriman G R; Odermatt B; Dougan G; Hengartner H; Zinkernagel R M
IgA production without mu or delta chain expression in developing B cells.
Nature immunology 2001;2(7):625-31.
2001: Zinkernagel R M
Immunity against solid tumors?
International journal of cancer. Journal international du cancer 2001;93(1):1-5.
2001: Ochsenbein A F; Sierro S; Odermatt B; Pericin M; Karrer U; Hermans J; Hemmi S; Hengartner H; Zinkernagel R M
Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction.
Nature 2001;411(6841):1058-64.
2001: Ludewig B; Bonilla W V; Dumrese T; Odermatt B; Zinkernagel R M; Hengartner H
Perforin-independent regulation of dendritic cell homeostasis by CD8(+) T cells in vivo: implications for adaptive immunotherapy.
European journal of immunology 2001;31(6):1772-9.
2001: Battegay M; Seiler P; Hunziker L; Wolf K; Zinkernagel R M
Neutralizing antiviral antibodies reduce hematogenic viral spread but not antiviral cytotoxic T cell induction and subsequent immunopathology.
The Journal of infectious diseases 2001;183(9):1425-7.
2001: Ciurea A; Hunziker L; Zinkernagel R M; Hengartner H
Viral escape from the neutralizing antibody response: the lymphocytic choriomeningitis virus model.
Immunogenetics 2001;53(3):185-9.
2001: Klein M A; Kaeser P S; Schwarz P; Weyd H; Xenarios I; Zinkernagel R M; Carroll M C; Verbeek J S; Botto M; Walport M J; Molina H; Kalinke U; Acha-Orbea H; Aguzzi A
Complement facilitates early prion pathogenesis.
Nature medicine 2001;7(4):488-92.
2001: Maloy K J; Erdmann I; Basch V; Sierro S; Kramps T A; Zinkernagel R M; Oehen S; Kündig T M
Intralymphatic immunization enhances DNA vaccination.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3299-303.
2001: Ludewig B; McCoy K; Pericin M; Ochsenbein A F; Dumrese T; Odermatt B; Toes R E; Melief C J; Hengartner H; Zinkernagel R M
Rapid peptide turnover and inefficient presentation of exogenous antigen critically limit the activation of self-reactive CTL by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(6):3678-87.
2001: Ludewig B; Jäggi M; Dumrese T; Brduscha-Riem K; Odermatt B; Hengartner H; Zinkernagel R M
Hypercholesterolemia exacerbates virus-induced immunopathologic liver disease via suppression of antiviral cytotoxic T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):3369-76.
2001: Ciurea A; Hunziker L; Klenerman P; Hengartner H; Zinkernagel R M
Impairment of CD4(+) T cell responses during chronic virus infection prevents neutralizing antibody responses against virus escape mutants.
The Journal of experimental medicine 2001;193(3):297-305.
2001: Zinkernagel R M; LaMarre A; Ciurea A; Hunziker L; Ochsenbein A F; McCoy K D; Fehr T; Bachmann M F; Kalinke U; Hengartner H
Neutralizing antiviral antibody responses.
Advances in immunology 2001;79():1-53.
2000: Ochsenbein A F; Zinkernagel R M
Natural antibodies and complement link innate and acquired immunity.
Immunology today 2000;21(12):624-30.
2000: Moretta L; Moretta A; Hengartner H; Zinkernagel R M
On the pathogenesis of perforin defects and related immunodeficiencies.
Immunology today 2000;21(11):593-4.
2000: Ludewig B; Zinkernagel R M; Hengartner H
Transgenic animal models for virus-induced autoimmune diseases.
Experimental physiology 2000;85(6):653-9.
2000: Ochsenbein A F; Pinschewer D D; Sierro S; Horvath E; Hengartner H; Zinkernagel R M
Protective long-term antibody memory by antigen-driven and T help-dependent differentiation of long-lived memory B cells to short-lived plasma cells independent of secondary lymphoid organs.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(24):13263-8.
2000: Ludewig B; Freigang S; Jäggi M; Kurrer M O; Pei Y C; Vlk L; Odermatt B; Zinkernagel R M; Hengartner H
Linking immune-mediated arterial inflammation and cholesterol-induced atherosclerosis in a transgenic mouse model.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(23):12752-7.
2000: Zinkernagel R M
Assessing the mechanisms that give rise to autoimmunity.
Science (New York, N.Y.) 2000;290(5489):11.
2000: Karrer U; Althage A; Odermatt B; Hengartner H; Zinkernagel R M
Immunodeficiency of alymphoplasia mice (aly/aly) in vivo: structural defect of secondary lymphoid organs and functional B cell defect.
European journal of immunology 2000;30(10):2799-807.
2000: Klenerman P; Lechner F; Kantzanou M; Ciurea A; Hengartner H; Zinkernagel R
Viral escape and the failure of cellular immune responses.
Science (New York, N.Y.) 2000;289(5487):2003.
2000: Zinkernagel R M
What is missing in immunology to understand immunity?
Nature immunology 2000;1(3):181-5.
2000: Fehr T; López-Macías C; Odermatt B; Torres R M; Schubart D B; O'Keefe T L; Matthias P; Hengartner H; Zinkernagel R M
Correlation of anti-viral B cell responses and splenic morphology with expression of B cell-specific molecules.
International immunology 2000;12(9):1275-84.
2000: Zinkernagel R M
Immunity 2000.
Immunology today 2000;21(9):422-3.
2000: Kalinke U; Oxenius A; Lopez-Macias C; Zinkernagel R M; Hengartner H
Virus neutralization by germ-line vs. hypermutated antibodies.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(18):10126-31.
2000: Ludewig B; Barchiesi F; Pericin M; Zinkernagel R M; Hengartner H; Schwendener R A
In vivo antigen loading and activation of dendritic cells via a liposomal peptide vaccine mediates protective antiviral and anti-tumour immunity.
Vaccine 2000;19(1):23-32.
2000: Knobeloch K P; Wright M D; Ochsenbein A F; Liesenfeld O; Löhler J; Zinkernagel R M; Horak I; Orinska Z
Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions.
Molecular and cellular biology 2000;20(15):5363-9.
2000: Seiler P; Senn B M; Klenerman P; Kalinke U; Hengartner H; Zinkernagel R M
Additive effect of neutralizing antibody and antiviral drug treatment in preventing virus escape and persistence.
Journal of virology 2000;74(13):5896-901.
2000: Zinkernagel R M
Localization dose and time of antigens determine immune reactivity.
Seminars in immunology 2000;12(3):163-71; discussion 257-344.
2000: Macpherson A J; Gatto D; Sainsbury E; Harriman G R; Hengartner H; Zinkernagel R M
A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria.
Science (New York, N.Y.) 2000;288(5474):2222-6.
2000: Maloy K J; Burkhart C; Junt T M; Odermatt B; Oxenius A; Piali L; Zinkernagel R M; Hengartner H
CD4(+) T cell subsets during virus infection. Protective capacity depends on effector cytokine secretion and on migratory capability.
The Journal of experimental medicine 2000;191(12):2159-70.
2000: Ochsenbein A F; Pinschewer D D; Odermatt B; Ciurea A; Hengartner H; Zinkernagel R M
Correlation of T cell independence of antibody responses with antigen dose reaching secondary lymphoid organs: implications for splenectomized patients and vaccine design.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6296-302.
2000: Pinschewer D D; Ochsenbein A F; Odermatt B; Brinkmann V; Hengartner H; Zinkernagel R M
FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(11):5761-70.
2000: Barchet W; Oehen S; Klenerman P; Wodarz D; Bocharov G; Lloyd A L; Nowak M A; Hengartner H; Zinkernagel R M; Ehl S
Direct quantitation of rapid elimination of viral antigen-positive lymphocytes by antiviral CD8(+) T cells in vivo.
European journal of immunology 2000;30(5):1356-63.
2000: Zinkernagel R M
On immunological memory.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2000;355(1395):369-71.
2000: Ehl S; Barchet W; Oehen S; Aichele P; Hombach J; Hengartner H; Zinkernagel R M
Donor cell persistence and activation-induced unresponsiveness of peripheral CD8+ T cells.
European journal of immunology 2000;30(3):883-91.
2000: Ludewig B; Ochsenbein A F; Odermatt B; Paulin D; Hengartner H; Zinkernagel R M
Immunotherapy with dendritic cells directed against tumor antigens shared with normal host cells results in severe autoimmune disease.
The Journal of experimental medicine 2000;191(5):795-804.
2000: Ciurea A; Klenerman P; Hunziker L; Horvath E; Senn B M; Ochsenbein A F; Hengartner H; Zinkernagel R M
Viral persistence in vivo through selection of neutralizing antibody-escape variants.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2749-54.
2000: Karrer U; López-Macías C; Oxenius A; Odermatt B; Bachmann M F; Kalinke U; Bluethmann H; Hengartner H; Zinkernagel R M
Antiviral B cell memory in the absence of mature follicular dendritic cell networks and classical germinal centers in TNFR1-/- mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(2):768-78.
2000: van Den Broek M; Bachmann M F; Köhler G; Barner M; Escher R; Zinkernagel R; Kopf M
IL-4 and IL-10 antagonize IL-12-mediated protection against acute vaccinia virus infection with a limited role of IFN-gamma and nitric oxide synthetase 2.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(1):371-8.
2000: Ludewig B; Maloy K J; López-Macías C; Odermatt B; Hengartner H; Zinkernagel R M
Induction of optimal anti-viral neutralizing B cell responses by dendritic cells requires transport and release of virus particles in secondary lymphoid organs.
European journal of immunology 2000;30(1):185-96.
1999: Ochsenbein A F; Fehr T; Lutz C; Suter M; Brombacher F; Hengartner H; Zinkernagel R M
Control of early viral and bacterial distribution and disease by natural antibodies.
Science (New York, N.Y.) 1999;286(5447):2156-9.
1999: Frigg R; Klein M A; Hegyi I; Zinkernagel R M; Aguzzi A
Scrapie pathogenesis in subclinically infected B-cell-deficient mice.
Journal of virology 1999;73(11):9584-8.
1999: Klenerman P; Zinkernagel R M
Of mice and men: cytotoxic T cells and AIDS pathogenesis.
The AIDS reader 1999;9(7):474-80.
1999: Ochsenbein A F; Pinschewer D D; Odermatt B; Carroll M C; Hengartner H; Zinkernagel R M
Protective T cell-independent antiviral antibody responses are dependent on complement.
The Journal of experimental medicine 1999;190(8):1165-74.
1999: Ciurea A; Klenerman P; Hunziker L; Horvath E; Odermatt B; Ochsenbein A F; Hengartner H; Zinkernagel R M
Persistence of lymphocytic choriomeningitis virus at very low levels in immune mice.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):11964-9.
1999: Pinschewer D D; Ochsenbein A F; Satterthwaite A B; Witte O N; Hengartner H; Zinkernagel R M
A Btk transgene restores the antiviral TI-2 antibody responses of xid mice in a dose-dependent fashion.
European journal of immunology 1999;29(9):2981-7.
1999: Ludewig B; Oehen S; Barchiesi F; Schwendener R A; Hengartner H; Zinkernagel R M
Protective antiviral cytotoxic T cell memory is most efficiently maintained by restimulation via dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):1839-44.
1999: Ochsenbein A F; Karrer U; Klenerman P; Althage A; Ciurea A; Shen H; Miller J F; Whitton J L; Hengartner H; Zinkernagel R M
A comparison of T cell memory against the same antigen induced by virus versus intracellular bacteria.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(16):9293-8.
1999: Zinkernagel R M; Althage A
On the role of thymic epithelium vs. bone marrow-derived cells in repertoire selection of T cells.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):8092-7.
1999: Ludewig B; Odermatt B; Ochsenbein A F; Zinkernagel R M; Hengartner H
Role of dendritic cells in the induction and maintenance of autoimmune diseases.
Immunological reviews 1999;169():45-54.
1999: López-Macías C; Kalinke U; Cascalho M; Wabl M; Hengartner H; Zinkernagel R M; Lamarre A
Secondary rearrangements and hypermutation generate sufficient B cell diversity to mount protective antiviral immunoglobulin responses.
The Journal of experimental medicine 1999;189(11):1791-8.
1999: Zinkernagel R M; Planz O; Ehl S; Battegay M; Odermatt B; Klenerman P; Hengartner H
General and specific immunosuppression caused by antiviral T-cell responses.
Immunological reviews 1999;168():305-15.
1999: Seiler P; Senn B M; Bründler M A; Zinkernagel R M; Hengartner H; Kalinke U
In vivo selection of neutralization-resistant virus variants but no evidence of B cell tolerance in lymphocytic choriomeningitis virus carrier mice expressing a transgenic virus-neutralizing antibody.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4536-41.
1999: Maloy K J; Burkhart C; Freer G; Rülicke T; Pircher H; Kono D H; Theofilopoulos A N; Ludewig B; Hoffmann-Rohrer U; Zinkernagel R M; Hengartner H
Qualitative and quantitative requirements for CD4+ T cell-mediated antiviral protection.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):2867-74.
1999: Ochsenbein A F; Klenerman P; Karrer U; Ludewig B; Pericin M; Hengartner H; Zinkernagel R M
Immune surveillance against a solid tumor fails because of immunological ignorance.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2233-8.
1999: Steinhoff U; Maloy K J; Burkhart C; Clark A J; Rülicke T; Hengartner H; Zinkernagel R M
Variable immune response against a developmentally regulated self-antigen.
Journal of autoimmunity 1999;12(1):27-34.
1999: Oxenius A; Karrer U; Zinkernagel R M; Hengartner H
IL-12 is not required for induction of type 1 cytokine responses in viral infections.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(2):965-73.
1998: Starzl T E; Zinkernagel R M
Antigen localization and migration in immunity and tolerance.
The New England journal of medicine 1998;339(26):1905-13.
1998: Klein M A; Frigg R; Raeber A J; Flechsig E; Hegyi I; Zinkernagel R M; Weissmann C; Aguzzi A
PrP expression in B lymphocytes is not required for prion neuroinvasion.
Nature medicine 1998;4(12):1429-33.
1998: Bachmann M F; Zinkernagel R M; Oxenius A
Immune responses in the absence of costimulation: viruses know the trick.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(11):5791-4.
1998: Gallimore A; Hombach J; Dumrese T; Rammensee H G; Zinkernagel R M; Hengartner H
A protective cytotoxic T cell response to a subdominant epitope is influenced by the stability of the MHC class I/peptide complex and the overall spectrum of viral peptides generated within infected cells.
European journal of immunology 1998;28(10):3301-11.
1998: Oxenius A; Zinkernagel R M; Hengartner H
Comparison of activation versus induction of unresponsiveness of virus-specific CD4+ and CD8+ T cells upon acute versus persistent viral infection.
Immunity 1998;9(4):449-57.
1998: André P; Groettrup M; Klenerman P; de Giuli R; Booth B L; Cerundolo V; Bonneville M; Jotereau F; Zinkernagel R M; Lotteau V
An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):13120-4.
1998: Ludewig B; Odermatt B; Landmann S; Hengartner H; Zinkernagel R M
Dendritic cells induce autoimmune diabetes and maintain disease via de novo formation of local lymphoid tissue.
The Journal of experimental medicine 1998;188(8):1493-501.
1998: Ehl S; Klenerman P; Zinkernagel R M; Bocharov G
The impact of variation in the number of CD8(+) T-cell precursors on the outcome of virus infection.
Cellular immunology 1998;189(1):67-73.
1998: Ehl S; Aichele P; Ramseier H; Barchet W; Hombach J; Pircher H; Hengartner H; Zinkernagel R M
Antigen persistence and time of T-cell tolerization determine the efficacy of tolerization protocols for prevention of skin graft rejection.
Nature medicine 1998;4(9):1015-9.
1998: Gallimore A; Hengartner H; Zinkernagel R
Hierarchies of antigen-specific cytotoxic T-cell responses.
Immunological reviews 1998;164():29-36.
1998: Fehr T; Naim H Y; Bachmann M F; Ochsenbein A F; Spielhofer P; Bucher E; Hengartner H; Billeter M A; Zinkernagel R M
T-cell independent IgM and enduring protective IgG antibodies induced by chimeric measles viruses.
Nature medicine 1998;4(8):945-8.
1998: Fehr T; Skrastina D; Pumpens P; Zinkernagel R M
T cell-independent type I antibody response against B cell epitopes expressed repetitively on recombinant virus particles.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9477-81.
1998: Klenerman P; Zinkernagel R M
Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes.
Nature 1998;394(6692):482-5.
1998: Fehr T; Rickert R C; Odermatt B; Roes J; Rajewsky K; Hengartner H; Zinkernagel R M
Antiviral protection and germinal center formation, but impaired B cell memory in the absence of CD19.
The Journal of experimental medicine 1998;188(1):145-55.
1998: Lutz C; Ledermann B; Kosco-Vilbois M H; Ochsenbein A F; Zinkernagel R M; Köhler G; Brombacher F
IgD can largely substitute for loss of IgM function in B cells.
Nature 1998;393(6687):797-801.
1998: Binder D; van den Broek M F; Kägi D; Bluethmann H; Fehr J; Hengartner H; Zinkernagel R M
Aplastic anemia rescued by exhaustion of cytokine-secreting CD8+ T cells in persistent infection with lymphocytic choriomeningitis virus.
The Journal of experimental medicine 1998;187(11):1903-20.
1998: Gallimore A; Dumrese T; Hengartner H; Zinkernagel R M; Rammensee H G
Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptides.
The Journal of experimental medicine 1998;187(10):1647-57.
1998: Gallimore A; Glithero A; Godkin A; Tissot A C; Plückthun A; Elliott T; Hengartner H; Zinkernagel R
Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes.
The Journal of experimental medicine 1998;187(9):1383-93.
1998: Ludewig B; Ehl S; Karrer U; Odermatt B; Hengartner H; Zinkernagel R M
Dendritic cells efficiently induce protective antiviral immunity.
Journal of virology 1998;72(5):3812-8.
1998: Seiler P; Kalinke U; Rülicke T; Bucher E M; Böse C; Zinkernagel R M; Hengartner H
Enhanced virus clearance by early inducible lymphocytic choriomeningitis virus-neutralizing antibodies in immunoglobulin-transgenic mice.
Journal of virology 1998;72(3):2253-8.
1998: Ehl S; Hombach J; Aichele P; Rülicke T; Odermatt B; Hengartner H; Zinkernagel R; Pircher H
Viral and bacterial infections interfere with peripheral tolerance induction and activate CD8+ T cells to cause immunopathology.
The Journal of experimental medicine 1998;187(5):763-74.
1998: Seiler P; Bründler M A; Zimmermann C; Weibel D; Bruns M; Hengartner H; Zinkernagel R M
Induction of protective cytotoxic T cell responses in the presence of high titers of virus-neutralizing antibodies: implications for passive and active immunization.
The Journal of experimental medicine 1998;187(4):649-54.
1998: Maloy K J; Odermatt B; Hengartner H; Zinkernagel R M
Interferon gamma-producing gammadelta T cell-dependent antibody isotype switching in the absence of germinal center formation during virus infection.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(3):1160-5.
1998: Oxenius A; Bachmann M F; Zinkernagel R M; Hengartner H
Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection.
European journal of immunology 1998;28(1):390-400.
1998: Oxenius A; Zinkernagel R M; Hengartner H
CD4+ T-cell induction and effector functions: a comparison of immunity against soluble antigens and viral infections.
Advances in immunology 1998;70():313-67.
1997: Ehl S; Klenerman P; Aichele P; Hengartner H; Zinkernagel R M
A functional and kinetic comparison of antiviral effector and memory cytotoxic T lymphocyte populations in vivo and in vitro.
European journal of immunology 1997;27(12):3404-13.
1997: Klein M A; Frigg R; Flechsig E; Raeber A J; Kalinke U; Bluethmann H; Bootz F; Suter M; Zinkernagel R M; Aguzzi A
A crucial role for B cells in neuroinvasive scrapie.
Nature 1997;390(6661):687-90.
1997: Zinkernagel R M
Gene technology and democracy.
Science (New York, N.Y.) 1997;278(5341):1207.
1997: Zinkernagel R M
The Nobel Lectures in Immunology. The Nobel Prize for Physiology or Medicine, 1996. Cellular immune recognition and the biological role of major transplantation antigens.
Scandinavian journal of immunology 1997;46(5):421-36.
1997: Klenerman P; Hengartner H; Zinkernagel R M
A non-retroviral RNA virus persists in DNA form.
Nature 1997;390(6657):298-301.
1997: Klenerman P; Zinkernagel R M
What can we learn about human immunodeficiency virus infection from a study of lymphocytic choriomeningitis virus?
Immunological reviews 1997;159():5-16.
1997: Seiler P; Aichele P; Odermatt B; Hengartner H; Zinkernagel R M; Schwendener R A
Crucial role of marginal zone macrophages and marginal zone metallophils in the clearance of lymphocytic choriomeningitis virus infection.
European journal of immunology 1997;27(10):2626-33.
1997: Kägi D; Odermatt B; Seiler P; Zinkernagel R M; Mak T W; Hengartner H
Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice.
The Journal of experimental medicine 1997;186(7):989-97.
1997: Bachmann M F; Oxenius A; Speiser D E; Mariathasan S; Hengartner H; Zinkernagel R M; Ohashi P S
Peptide-induced T cell receptor down-regulation on naive T cells predicts agonist/partial agonist properties and strictly correlates with T cell activation.
European journal of immunology 1997;27(9):2195-203.
1997: Zinkernagel R M
Felix Hoppe-Seyler Lecture 1997. Protective antibody responses against viruses.
Biological chemistry 1997;378(8):725-9.
1997: Speiser D E; Miranda R; Zakarian A; Bachmann M F; McKall-Faienza K; Odermatt B; Hanahan D; Zinkernagel R M; Ohashi P S
Self antigens expressed by solid tumors Do not efficiently stimulate naive or activated T cells: implications for immunotherapy.
The Journal of experimental medicine 1997;186(5):645-53.
1997: van den Broek M F; Spörri R; Even C; Plagemann P G; Hänseler E; Hengartner H; Zinkernagel R M
Lactate dehydrogenase-elevating virus (LDV): lifelong coexistence of virus and LDV-specific immunity.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(4):1585-8.
1997: Zinkernagel R; Klenerman P
Immune surveillance and AIDS progression.
Current biology : CB 1997;7(7):R403-5.
1997: Bachmann M F; Kalinke U; Althage A; Freer G; Burkhart C; Roost H; Aguet M; Hengartner H; Zinkernagel R M
The role of antibody concentration and avidity in antiviral protection.
Science (New York, N.Y.) 1997;276(5321):2024-7.
1997: Planz O; Ehl S; Furrer E; Horvath E; Bründler M A; Hengartner H; Zinkernagel R M
A critical role for neutralizing-antibody-producing B cells, CD4(+) T cells, and interferons in persistent and acute infections of mice with lymphocytic choriomeningitis virus: implications for adoptive immunotherapy of virus carriers.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6874-9.
1997: Oxenius A; Bachmann M F; Mathis D; Benoist C; Zinkernagel R M; Hengartner H
Functional in vivo MHC class II loading by endogenously synthesized glycoprotein during viral infection.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(12):5717-26.
1997: Zinkernagel R M; Hengartner H
Antiviral immunity.
Immunology today 1997;18(6):258-60.
1997: Karrer U; Althage A; Odermatt B; Roberts C W; Korsmeyer S J; Miyawaki S; Hengartner H; Zinkernagel R M
On the key role of secondary lymphoid organs in antiviral immune responses studied in alymphoplastic (aly/aly) and spleenless (Hox11(-)/-) mutant mice.
The Journal of experimental medicine 1997;185(12):2157-70.
1997: Bachmann M F; Fehr T; Freer G; Hengartner H; Zinkernagel R M
Correlation of tolerogenicity of a viral antigen with its immunogenicity.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(11):5106-11.
1997: Aichele P; Brduscha-Riem K; Oehen S; Odermatt B; Zinkernagel R M; Hengartner H; Pircher H
Peptide antigen treatment of naive and virus-immune mice: antigen-specific tolerance versus immunopathology.
Immunity 1997;6(5):519-29.
1997: Fehr T; Bachmann M F; Bucher E; Kalinke U; Di Padova F E; Lang A B; Hengartner H; Zinkernagel R M
Role of repetitive antigen patterns for induction of antibodies against antibodies.
The Journal of experimental medicine 1997;185(10):1785-92.
1997: Zinkernagel R M
Cellular immune recognition and the biological role of major transplantation antigens.
Bioscience reports 1997;17(2):91-111.
1997: Zinkernagel R M; Ehl S; Aichele P; Oehen S; Kündig T; Hengartner H
Antigen localisation regulates immune responses in a dose- and time-dependent fashion: a geographical view of immune reactivity.
Immunological reviews 1997;156():199-209.
1997: Ehl S; Hombach J; Aichele P; Hengartner H; Zinkernagel R M
Bystander activation of cytotoxic T cells: studies on the mechanism and evaluation of in vivo significance in a transgenic mouse model.
The Journal of experimental medicine 1997;185(7):1241-51.
1997: Fehr T; Schoedon G; Odermatt B; Holtschke T; Schneemann M; Bachmann M F; Mak T W; Horak I; Zinkernagel R M
Crucial role of interferon consensus sequence binding protein, but neither of interferon regulatory factor 1 nor of nitric oxide synthesis for protection against murine listeriosis.
The Journal of experimental medicine 1997;185(5):921-31.
1997: Zimmermann C; Seiler P; Lane P; Zinkernagel R M
Antiviral immune responses in CTLA4 transgenic mice.
Journal of virology 1997;71(3):1802-7.
1997: Binder D; Fehr J; Hengartner H; Zinkernagel R M
Virus-induced transient bone marrow aplasia: major role of interferon-alpha/beta during acute infection with the noncytopathic lymphocytic choriomeningitis virus.
The Journal of experimental medicine 1997;185(3):517-30.
1997: Zinkernagel R M; Doherty P C
The discovery of MHC restriction.
Immunology today 1997;18(1):14-7.
1997: Bachmann M F; Kündig T M; Hengartner H; Zinkernagel R M
Protection against immunopathological consequences of a viral infection by activated but not resting cytotoxic T cells: T cell memory without "memory T cells"?
Proceedings of the National Academy of Sciences of the United States of America 1997;94(2):640-5.
1997: Bachmann M F; Zinkernagel R M
Neutralizing antiviral B cell responses.
Annual review of immunology 1997;15():235-70.
1997: Zinkernagel R M
Immunology and immunity studied with viruses.
Ciba Foundation symposium 1997;204():105-25; discussion 125-9.
1996: Bachmann M F; Zinkernagel R M
The influence of virus structure on antibody responses and virus serotype formation.
Immunology today 1996;17(12):553-8.
1996: Kalinke U; Bucher E M; Ernst B; Oxenius A; Roost H P; Geley S; Kofler R; Zinkernagel R M; Hengartner H
The role of somatic mutation in the generation of the protective humoral immune response against vesicular stomatitis virus.
Immunity 1996;5(6):639-52.
1996: Ehl S; Nuesch R; Tanaka T; Myasaka M; Hengartner H; Zinkernagel R
A comparison of efficacy and specificity of three NK depleting antibodies.
Journal of immunological methods 1996;199(2):149-53.
1996: Kalinke U; Krebber A; Krebber C; Bucher E; Plückthun A; Zinkernagel R M; Hengartner H
Monovalent single-chain Fv fragments and bivalent miniantibodies bound to vesicular stomatitis virus protect against lethal infection.
European journal of immunology 1996;26(12):2801-6.
1996: van den Broek M E; Kägi D; Ossendorp F; Toes R; Vamvakas S; Lutz W K; Melief C J; Zinkernagel R M; Hengartner H
Decreased tumor surveillance in perforin-deficient mice.
The Journal of experimental medicine 1996;184(5):1781-90.
1996: Holtschke T; Löhler J; Kanno Y; Fehr T; Giese N; Rosenbauer F; Lou J; Knobeloch K P; Gabriele L; Waring J F; Bachmann M F; Zinkernagel R M; Morse H C; Ozato K; Horak I
Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene.
Cell 1996;87(2):307-17.
1996: Bründler M A; Aichele P; Bachmann M; Kitamura D; Rajewsky K; Zinkernagel R M
Immunity to viruses in B cell-deficient mice: influence of antibodies on virus persistence and on T cell memory.
European journal of immunology 1996;26(9):2257-62.
1996: Kündig T M; Bachmann M F; Oehen S; Hoffmann U W; Simard J J; Kalberer C P; Pircher H; Ohashi P S; Hengartner H; Zinkernagel R M
On the role of antigen in maintaining cytotoxic T-cell memory.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(18):9716-23.
1996: Aichele P; Bachmann M F; Hengartner H; Zinkernagel R M
Immunopathology or organ-specific autoimmunity as a consequence of virus infection.
Immunological reviews 1996;152():21-45.
1996: Bloom B; Zinkernagel R
Immunity to infection.
Current opinion in immunology 1996;8(4):465-6.
1996: Planz O; Seiler P; Hengartner H; Zinkernagel R M
Specific cytotoxic T cells eliminate B cells producing virus-neutralizing antibodies [corrected]
Nature 1996;382(6593):726-9.
1996: Zinkernagel R M; Hengartner H
Correlates of protective viruses damaging to HIV infection.
Science (New York, N.Y.) 1996;272(5266):1362.
1996: Bachmann M F; Odermatt B; Hengartner H; Zinkernagel R M
Induction of long-lived germinal centers associated with persisting antigen after viral infection.
The Journal of experimental medicine 1996;183(5):2259-69.
1996: Oxenius A; Campbell K A; Maliszewski C R; Kishimoto T; Kikutani H; Hengartner H; Zinkernagel R M; Bachmann M F
CD40-CD40 ligand interactions are critical in T-B cooperation but not for other anti-viral CD4+ T cell functions.
The Journal of experimental medicine 1996;183(5):2209-18.
1996: Kägi D; Odermatt B; Ohashi P S; Zinkernagel R M; Hengartner H
Development of insulitis without diabetes in transgenic mice lacking perforin-dependent cytotoxicity.
The Journal of experimental medicine 1996;183(5):2143-52.
1996: Ehl S; Hoffmann-Rohrer U; Nagata S; Hengartner H; Zinkernagel R
Different susceptibility of cytotoxic T cells to CD95 (Fas/Apo-1) ligand-mediated cell death after activation in vitro versus in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(7):2357-60.
1996: Kündig T M; Bachmann M F; Ohashi P S; Pircher H; Hengartner H; Zinkernagel R M
On T cell memory: arguments for antigen dependence.
Immunological reviews 1996;150():63-90.
1996: Zimmerman C; Brduscha-Riem K; Blaser C; Zinkernagel R M; Pircher H
Visualization, characterization, and turnover of CD8+ memory T cells in virus-infected hosts.
The Journal of experimental medicine 1996;183(4):1367-75.
1996: Fehr T; Bachmann M F; Bluethmann H; Kikutani H; Hengartner H; Zinkernagel R M
T-independent activation of B cells by vesicular stomatitis virus: no evidence for the need of a second signal.
Cellular immunology 1996;168(2):184-92.
1996: Roost H P; Haag A; Burkhart C; Zinkernagel R M; Hengartner H
Mapping of the dominant neutralizing antigenic site of a virus using infected cells.
Journal of immunological methods 1996;189(2):233-42.
1996: Eugster H P; Muller M; Karrer U; Car B D; Schnyder B; Eng V M; Woerly G; Le Hir M; di Padova F; Aguet M; Zinkernagel R; Bluethmann H; Ryffel B
Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-alpha double-deficient mice.
International immunology 1996;8(1):23-36.
1996: Battegay M; Fiedler P; Kalinke U; Brombacher F; Zinkernagel R M; Peter H H; Köhler G; Eibel H
Non-tolerant B cells cause autoimmunity in anti-CD8 IgG2a-transgenic mice.
European journal of immunology 1996;26(1):250-8.
1996: Battegay M; Bachmann M F; Burhkart C; Viville S; Benoist C; Mathis D; Hengartner H; Zinkernagel R M
Antiviral immune responses of mice lacking MHC class II or its associated invariant chain.
Cellular immunology 1996;167(1):115-21.
1996: Zinkernagel R M
Immunology taught by viruses.
Science (New York, N.Y.) 1996;271(5246):173-8.
1996: Zinkernagel R M; Bachmann M F; Kündig T M; Oehen S; Pirchet H; Hengartner H
On immunological memory.
Annual review of immunology 1996;14():333-67.
1996: Kägi D; Ledermann B; Bürki K; Zinkernagel R M; Hengartner H
Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo.
Annual review of immunology 1996;14():207-32.
1995: van den Broek M F; Müller U; Huang S; Zinkernagel R M; Aguet M
Immune defence in mice lacking type I and/or type II interferon receptors.
Immunological reviews 1995;148():5-18.
1995: van den Broek M F; Kägi D; Zinkernagel R M; Hengartner H
Perforin dependence of natural killer cell-mediated tumor control in vivo.
European journal of immunology 1995;25(12):3514-6.
1995: Bachmann M F; Hengartner H; Zinkernagel R M
T helper cell-independent neutralizing B cell response against vesicular stomatitis virus: role of antigen patterns in B cell induction?
European journal of immunology 1995;25(12):3445-51.
1995: Oxenius A; Bachmann M F; Ashton-Rickardt P G; Tonegawa S; Zinkernagel R M; Hengartner H
Presentation of endogenous viral proteins in association with major histocompatibility complex class II: on the role of intracellular compartmentalization, invariant chain and the TAP transporter system.
European journal of immunology 1995;25(12):3402-11.
1995: Kägi D; Seiler P; Pavlovic J; Ledermann B; Bürki K; Zinkernagel R M; Hengartner H
The roles of perforin- and Fas-dependent cytotoxicity in protection against cytopathic and noncytopathic viruses.
European journal of immunology 1995;25(12):3256-62.
1995: Hombach J; Pircher H; Tonegawa S; Zinkernagel R M
Strictly transporter of antigen presentation (TAP)-dependent presentation of an immunodominant cytotoxic T lymphocyte epitope in the signal sequence of a virus protein.
The Journal of experimental medicine 1995;182(5):1615-9.
1995: Gilfillan S; Bachmann M; Trembleau S; Adorini L; Kalinke U; Zinkernagel R; Benoist C; Mathis D
Efficient immune responses in mice lacking N-region diversity.
European journal of immunology 1995;25(11):3115-22.
1995: Zinkernagel R M
The 1995 Albert Lasker Medical Research Award. MHC-restricted T-cell recognition. The basis of immune surveillance.
JAMA : the journal of the American Medical Association 1995;274(13):1069-71.
1995: Bachmann M F; Oxenius A; Mak T W; Zinkernagel R M
T cell development in CD8-/- mice. Thymic positive selection is biased toward the helper phenotype.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(8):3727-33.
1995: Bachmann M F; Schorle H; Kühn R; Müller W; Hengartner H; Zinkernagel R M; Horak I
Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4.
Journal of virology 1995;69(8):4842-6.
1995: van den Broek M F; Müller U; Huang S; Aguet M; Zinkernagel R M
Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors.
Journal of virology 1995;69(8):4792-6.
1995: Zinkernagel R M
Are HIV-specific CTL responses salutary or pathogenic?
Current opinion in immunology 1995;7(4):462-70.
1995: Kägi D; Ledermann B; Bürki K; Zinkernagel R M; Hengartner H
Lymphocyte-mediated cytotoxicity in vitro and in vivo: mechanisms and significance.
Immunological reviews 1995;146():95-115.
1995: Aichele P; Brduscha-Riem K; Zinkernagel R M; Hengartner H; Pircher H
T cell priming versus T cell tolerance induced by synthetic peptides.
The Journal of experimental medicine 1995;182(1):261-6.
1995: Bachmann M F; Oxenius A; Pircher H; Hengartner H; Ashton-Richardt P A; Tonegawa S; Zinkernagel R M
TAP1-independent loading of class I molecules by exogenous viral proteins.
European journal of immunology 1995;25(6):1739-43.
1995: Hengel H; Burke K; Kyburz D; Zinkernagel R M; Koszinowski U H
Peptides control the gain and loss of allele specificity by mutated MHC class I molecules.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(9):4557-64.
1995: Freer G; Burkhart C; Rülicke T; Ghelardi E; Rohrer U H; Pircher H; Zinkernagel R M; Hengartner H
Role of T helper cell precursor frequency on vesicular stomatitis virus neutralizing antibody responses in a T cell receptor beta chain transgenic mouse.
European journal of immunology 1995;25(5):1410-6.
1995: Steinhoff U; Müller U; Schertler A; Hengartner H; Aguet M; Zinkernagel R M
Antiviral protection by vesicular stomatitis virus-specific antibodies in alpha/beta interferon receptor-deficient mice.
Journal of virology 1995;69(4):2153-8.
1995: Moskophidis D; Zinkernagel R M
Immunobiology of cytotoxic T-cell escape mutants of lymphocytic choriomeningitis virus.
Journal of virology 1995;69(4):2187-93.
1995: Roost H P; Bachmann M F; Haag A; Kalinke U; Pliska V; Hengartner H; Zinkernagel R M
Early high-affinity neutralizing anti-viral IgG responses without further overall improvements of affinity.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1257-61.
1995: Schulz M; Schuurman H J; Joergensen J; Steiner C; Meerloo T; Kägi D; Hengartner H; Zinkernagel R M; Schreier M H; Bürki K
Acute rejection of vascular heart allografts by perforin-deficient mice.
European journal of immunology 1995;25(2):474-80.
1995: Moskophidis D; Battegay M; van den Broek M; Laine E; Hoffmann-Rohrer U; Zinkernagel R M
Role of virus and host variables in virus persistence or immunopathological disease caused by a non-cytolytic virus.
The Journal of general virology 1995;76 ( Pt 2)():381-91.
1995: Zinkernagel R M; Hengartner H
Viral immunopathology. Introduction.
Springer seminars in immunopathology 1995;17(2-3):119-20.
1995: Zinkernagel R M
Immunosuppression by a noncytolytic virus via T cell mediated immunopathology. Implication for AIDS.
Advances in experimental medicine and biology 1995;374():165-71.
1994: Zinkernagel R M
Some general aspects of immunity to viruses.
Vaccine 1994;12(16):1493-4.
1994: Kägi D; Ledermann B; Bürki K; Hengartner H; Zinkernagel R M
CD8+ T cell-mediated protection against an intracellular bacterium by perforin-dependent cytotoxicity.
European journal of immunology 1994;24(12):3068-72.
1994: Bachmann M F; Rohrer U H; Steinhoff U; Bürki K; Skuntz S; Arnheiter H; Hengartner H; Zinkernagel R M
T helper cell unresponsiveness: rapid induction in antigen-transgenic and reversion in non-transgenic mice.
European journal of immunology 1994;24(12):2966-73.
1994: Bachmann M F; Hengartner H; Zinkernagel R M
Immunization with recombinant protein: conditions for cytotoxic T cell and/or antibody induction.
Medical microbiology and immunology 1994;183(6):315-24.
1994: Bachmann M F; Kündig T M; Odermatt B; Hengartner H; Zinkernagel R M
Free recirculation of memory B cells versus antigen-dependent differentiation to antibody-forming cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(8):3386-97.
1994: Bachmann M F; Kündig T M; Hengartner H; Zinkernagel R M
Regulation of IgG antibody titers by the amount persisting of immune-complexed antigen.
European journal of immunology 1994;24(10):2567-70.
1994: Oehen S U; Ohashi P S; Bürki K; Hengartner H; Zinkernagel R M; Aichele P
Escape of thymocytes and mature T cells from clonal deletion due to limiting tolerogen expression levels.
Cellular immunology 1994;158(2):342-52.
1994: Bachmann M F; Kündig T M; Freer G; Li Y; Kang C Y; Bishop D H; Hengartner H; Zinkernagel R M
Induction of protective cytotoxic T cells with viral proteins.
European journal of immunology 1994;24(9):2228-36.
1994: Rahemtulla A; Kündig T M; Narendran A; Bachmann M F; Julius M; Paige C J; Ohashi P S; Zinkernagel R M; Mak T W
Class II major histocompatibility complex-restricted T cell function in CD4-deficient mice.
European journal of immunology 1994;24(9):2213-8.
1994: Battegay M; Moskophidis D; Rahemtulla A; Hengartner H; Mak T W; Zinkernagel R M
Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice.
Journal of virology 1994;68(7):4700-4.
1994: Müller U; Steinhoff U; Reis L F; Hemmi S; Pavlovic J; Zinkernagel R M; Aguet M
Functional role of type I and type II interferons in antiviral defense.
Science (New York, N.Y.) 1994;264(5167):1918-21.
1994: Zinkernagel R M; Hengartner H
T-cell-mediated immunopathology versus direct cytolysis by virus: implications for HIV and AIDS.
Immunology today 1994;15(6):262-8.
1994: Freer G; Burkhart C; Ciernik I; Bachmann M F; Hengartner H; Zinkernagel R M
Vesicular stomatitis virus Indiana glycoprotein as a T-cell-dependent and -independent antigen.
Journal of virology 1994;68(6):3650-5.
1994: Allen P M; Zinkernagel R M
Promethean viruses?
Nature 1994;369(6479):355-6.
1994: Moskophidis D; Lechner F; Hengartner H; Zinkernagel R M
MHC class I and non-MHC-linked capacity for generating an anti-viral CTL response determines susceptibility to CTL exhaustion and establishment of virus persistence in mice.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(10):4976-83.
1994: Kägi D; Ledermann B; Bürki K; Seiler P; Odermatt B; Olsen K J; Podack E R; Zinkernagel R M; Hengartner H
Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice.
Nature 1994;369(6475):31-7.
1994: Bachmann M F; Bast C; Hengartner H; Zinkernagel R M
Immunogenicity of a viral model vaccine after different inactivation procedures.
Medical microbiology and immunology 1994;183(2):95-104.
1994: Bachmann M F; Kündig T M; Kalberer C P; Hengartner H; Zinkernagel R M
How many specific B cells are needed to protect against a virus?
Journal of immunology (Baltimore, Md. : 1950) 1994;152(9):4235-41.
1994: Kopf M; Baumann H; Freer G; Freudenberg M; Lamers M; Kishimoto T; Zinkernagel R; Bluethmann H; Köhler G
Impaired immune and acute-phase responses in interleukin-6-deficient mice.
Nature 1994;368(6469):339-42.
1994: Lindemann D; Wilhelm R; Renard P; Althage A; Zinkernagel R; Mous J
Severe immunodeficiency associated with a human immunodeficiency virus 1 NEF/3'-long terminal repeat transgene.
The Journal of experimental medicine 1994;179(3):797-807.
1994: Moskophidis D; Battegay M; Bruendler M A; Laine E; Gresser I; Zinkernagel R M
Resistance of lymphocytic choriomeningitis virus to alpha/beta interferon and to gamma interferon.
Journal of virology 1994;68(3):1951-5.
1994: Steinhoff U; Burkhart C; Arnheiter H; Hengartner H; Zinkernagel R
Virus or a hapten-carrier complex can activate autoreactive B cells by providing linked T help.
European journal of immunology 1994;24(3):773-6.
1994: Burkhart C; Freer G; Castro R; Adorini L; Wiesmüller K H; Zinkernagel R M; Hengartner H
Characterization of T-helper epitopes of the glycoprotein of vesicular stomatitis virus.
Journal of virology 1994;68(3):1573-80.
1994: Ashton-Rickardt P G; Bandeira A; Delaney J R; Van Kaer L; Pircher H P; Zinkernagel R M; Tonegawa S
Evidence for a differential avidity model of T cell selection in the thymus.
Cell 1994;76(4):651-63.
1994: Aichele P; Kyburz D; Ohashi P S; Odermatt B; Zinkernagel R M; Hengartner H; Pircher H
Peptide-induced T-cell tolerance to prevent autoimmune diabetes in a transgenic mouse model.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(2):444-8.
1994: Zinkernagel R M
The role of antigen in maintaining T cell memory.
Developments in biological standardization 1994;82():189-91.
1994: Burkhart C; Freer G; Steinhoff U; Li Y; Bishop D H; Zinkernagel R M; Hengartner H
Localization of T helper cell epitopes in the vesicular stomatitis virus: the nucleoprotein is responsible for serotype cross-reactive T help.
Viral immunology 1994;7(3):103-11.
1994: Zinkernagel R
[Virus-induced immune deficiency disease AIDS: direct pathogenic effect of the virus or immunopathology?]
Verhandlungen der Deutschen Gesellschaft für Pathologie 1994;78():166-70.
1993: Moskophidis D; Laine E; Zinkernagel R M
Peripheral clonal deletion of antiviral memory CD8+ T cells.
European journal of immunology 1993;23(12):3306-11.
1993: Battegay M; Kyburz D; Hengartner H; Zinkernagel R M
Enhancement of disease by neutralizing antiviral antibodies in the absence of primed antiviral cytotoxic T cells.
European journal of immunology 1993;23(12):3236-41.
1993: Bachmann M F; Rohrer U H; Kündig T M; Bürki K; Hengartner H; Zinkernagel R M
The influence of antigen organization on B cell responsiveness.
Science (New York, N.Y.) 1993;262(5138):1448-51.
1993: Kündig T M; Schorle H; Bachmann M F; Hengartner H; Zinkernagel R M; Horak I
Immune responses in interleukin-2-deficient mice.
Science (New York, N.Y.) 1993;262(5136):1059-61.
1993: Weibel D; Bründler M A; Zinkernagel R M; Battegay M
Analysis of neutralizing antibody specificities of different strains of lymphocytic choriomeningitis virus with strain-specific immune sera.
Research in virology 1993;144(6):471-8.
1993: Battegay M; Moskophidis D; Waldner H; Bründler M A; Fung-Leung W P; Mak T W; Hengartner H; Zinkernagel R M
Impairment and delay of neutralizing antiviral antibody responses by virus-specific cytotoxic T cells.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(10):5408-15.
1993: Castelmur I; DiPaolo C; Bachmann M F; Hengartner H; Zinkernagel R M; Kündig T M
Comparison of the sensitivity of in vivo and in vitro assays for detection of antiviral cytotoxic T cell activity.
Cellular immunology 1993;151(2):460-6.
1993: Rahemtulla A; Shahinian A; Kundig T; Zinkernagel R; Mak T W
CD4 negative mice as a model for immunodeficiency.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1993;342(1299):57-8.
1993: Rothe J; Lesslauer W; Lötscher H; Lang Y; Koebel P; Köntgen F; Althage A; Zinkernagel R; Steinmetz M; Bluethmann H
Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes.
Nature 1993;364(6440):798-802.
1993: Kyburz D; Aichele P; Speiser D E; Hengartner H; Zinkernagel R M; Pircher H
T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides.
European journal of immunology 1993;23(8):1956-62.
1993: Molina T J; Bachmann M F; Kündig T M; Zinkernagel R M; Mak T W
Peripheral T cells in mice lacking p56lck do not express significant antiviral effector functions.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(2):699-706.
1993: Bachmann M F; Kündig T M; Kalberer C P; Hengartner H; Zinkernagel R M
Formalin inactivation of vesicular stomatitis virus impairs T-cell- but not T-help-independent B-cell responses.
Journal of virology 1993;67(7):3917-22.
1993: Kyburz D; Speiser D E; Battegay M; Hengartner H; Zinkernagel R M
Lysis of infected cells in vivo by antiviral cytolytic T cells demonstrated by release of cell internal viral proteins.
European journal of immunology 1993;23(7):1540-5.
1993: Ohashi P S; Oehen S; Aichele P; Pircher H; Odermatt B; Herrera P; Higuchi Y; Buerki K; Hengartner H; Zinkernagel R M
Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and tumor necrosis factor-alpha.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(11):5185-94.
1993: Zinkernagel R M; Moskophidis D; Kündig T; Oehen S; Pircher H; Hengartner H
Effector T-cell induction and T-cell memory versus peripheral deletion of T cells.
Immunological reviews 1993;133():199-223.
1993: Kündig T M; Castelmur I; Bachmann M F; Abraham D; Binder D; Hengartner H; Zinkernagel R M
Fewer protective cytotoxic T-cell epitopes than T-helper-cell epitopes on vesicular stomatitis virus.
Journal of virology 1993;67(6):3680-3.
1993: Kyburz D; Speiser D E; Aebischer T; Hengartner H; Zinkernagel R M
Virus-specific cytotoxic T cell-mediated lysis of lymphocytes in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(11):5051-8.
1993: Kündig T M; Bachmann M F; Lefrancois L; Puddington L; Hengartner H; Zinkernagel R M
Nonimmunogenic tumor cells may efficiently restimulate tumor antigen-specific cytotoxic T cells.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(10):4450-6.
1993: Moskophidis D; Lechner F; Pircher H; Zinkernagel R M
Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells.
Nature 1993;362(6422):758-61.
1993: Zinkernagel R M
[Autoimmune diseases]
Immunität und Infektion 1993;21 Suppl 1():7-9.
1993: Zinkernagel R M
Immune protection vs. immunopathology vs. autoimmunity: a question of balance and of knowledge.
Brain pathology (Zurich, Switzerland) 1993;3(2):115-21.
1993: Huang S; Hendriks W; Althage A; Hemmi S; Bluethmann H; Kamijo R; Vilcek J; Zinkernagel R M; Aguet M
Immune response in mice that lack the interferon-gamma receptor.
Science (New York, N.Y.) 1993;259(5102):1742-5.
1993: Kündig T M; Hengartner H; Zinkernagel R M
T cell-dependent IFN-gamma exerts an antiviral effect in the central nervous system but not in peripheral solid organs.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(6):2316-21.
1993: Pircher H; Brduscha K; Steinhoff U; Kasai M; Mizuochi T; Zinkernagel R M; Hengartner H; Kyewski B; Müller K P
Tolerance induction by clonal deletion of CD4+8+ thymocytes in vitro does not require dedicated antigen-presenting cells.
European journal of immunology 1993;23(3):669-74.
1993: Zinkernagel R M; Hengartner H
[Model concepts on the development of so-called autoimmune diseases]
Therapeutische Umschau. Revue thérapeutique 1993;50(2):66-70.
1993: Ohashi P S; Zinkernagel R M; Leuscher I; Hengartner H; Pircher H
Enhanced positive selection of a transgenic TCR by a restriction element that does not permit negative selection.
International immunology 1993;5(2):131-8.
1993: Zinkernagel R M; Hengartner H
Contra: CD8+ T-cell-mediated suppression without 'suppressor' T cells?
International archives of allergy and immunology 1993;100(1):8-11.
1993: Kündig T M; Kalberer C P; Hengartner H; Zinkernagel R M
Vaccination with two different vaccinia recombinant viruses: long-term inhibition of secondary vaccination.
Vaccine 1993;11(11):1154-8.
1993: Zinkernagel R M
Protection and damage by antiviral immunity.
Harvey lectures 1993;89():29-51.
1992: Oehen S; Ohashi P S; Aichele P; Bürki K; Hengartner H; Zinkernagel R M
Vaccination or tolerance to prevent diabetes.
European journal of immunology 1992;22(12):3149-53.
1992: Zinkernagel R M
Virus-induced acquired immune suppression by cytotoxic T cell-mediated immunopathology.
Veterinary microbiology 1992;33(1-4):13-8.
1992: Oehen S; Waldner H; Kündig T M; Hengartner H; Zinkernagel R M
Antivirally protective cytotoxic T cell memory to lymphocytic choriomeningitis virus is governed by persisting antigen.
The Journal of experimental medicine 1992;176(5):1273-81.
1992: Speiser D E; Kyburz D; Stübi U; Hengartner H; Zinkernagel R M
Discrepancy between in vitro measurable and in vivo virus neutralizing cytotoxic T cell reactivities. Low T cell receptor specificity and avidity sufficient for in vitro proliferation or cytotoxicity to peptide-coated target cells but not for in vivo protection.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(3):972-80.
1992: Zinkernagel R M; Hengartner H
Virally induced immunosuppression.
Current opinion in immunology 1992;4(4):408-12.
1992: Schneider R; Pircher H; Speiser D E; Zinkernagel R; Hengartner H
Kinetics of clonal deletion varies with tolerizing antigen.
Thymus 1992;20(1):5-15.
1992: Buchmeier M J; Zinkernagel R M
Immunodominant T cell epitope from signal sequence.
Science (New York, N.Y.) 1992;257(5073):1142.
1992: Kündig T M; Althage A; Hengartner H; Zinkernagel R M
Skin test to assess virus-specific cytotoxic T-cell activity.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7757-61.
1992: Althage A; Odermatt B; Moskophidis D; Kündig T; Hoffman-Rohrer U; Hengartner H; Zinkernagel R M
Immunosuppression by lymphocytic choriomeningitis virus infection: competent effector T and B cells but impaired antigen presentation.
European journal of immunology 1992;22(7):1803-12.
1992: Moskophidis D; Pircher H; Ciernik I; Odermatt B; Hengartner H; Zinkernagel R M
Suppression of virus-specific antibody production by CD8+ class I-restricted antiviral cytotoxic T cells in vivo.
Journal of virology 1992;66(6):3661-8.
1992: Speiser D E; Pircher H; Ohashi P S; Kyburz D; Hengartner H; Zinkernagel R M
Clonal deletion induced by either radioresistant thymic host cells or lymphohemopoietic donor cells at different stages of class I-restricted T cell ontogeny.
The Journal of experimental medicine 1992;175(5):1277-83.
1992: Speiser D E; Roosnek E; Jeannet M; Zinkernagel R M
T-cell immunoincompetence in allogeneic chimerism.
The New England journal of medicine 1992;326(15):1028-9.
1992: Zinkernagel R M; Hengartner H
T cells causing immunological disease: immunopathology or autoimmunity?
Research in immunology 1992;143(3):310-3.
1992: Battegay M; Oehen S; Schulz M; Hengartner H; Zinkernagel R M
Vaccination with a synthetic peptide modulates lymphocytic choriomeningitis virus-mediated immunopathology.
Journal of virology 1992;66(2):1199-201.
1992: Pircher H; Rebaï N; Groettrup M; Grégoire C; Speiser D E; Happ M P; Palmer E; Zinkernagel R M; Hengartner H; Malissen B
Preferential positive selection of V alpha 2+ CD8+ T cells in mouse strains expressing both H-2k and T cell receptor V alpha a haplotypes: determination with a V alpha 2-specific monoclonal antibody.
European journal of immunology 1992;22(2):399-404.
1992: Speiser D E; Stübi U; Zinkernagel R M
Extrathymic positive selection of alpha beta T-cell precursors in nude mice.
Nature 1992;355(6356):170-2.
1992: Zinkernagel R M; Pircher H; Ohashi P S; Hengartner H
T cells causing immunological disease.
Springer seminars in immunopathology 1992;14(2):105-13.
1992: Zinkernagel R M
How can we stimulate the immune system in vivo?
Developments in biological standardization 1992;77():29-30.
1991: Aebischer T; Moskophidis D; Rohrer U H; Zinkernagel R M; Hengartner H
In vitro selection of lymphocytic choriomeningitis virus escape mutants by cytotoxic T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11047-51.
1991: Zinkernagel R M; Hengartner H
HIV. Games that viruses play.
Nature 1991;354(6353):433-4.
1991: Fung-Leung W P; Kündig T M; Zinkernagel R M; Mak T W
Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression.
The Journal of experimental medicine 1991;174(6):1425-9.
1991: Odermatt B; Eppler M; Leist T P; Hengartner H; Zinkernagel R M
Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(18):8252-6.
1991: Rahemtulla A; Fung-Leung W P; Schilham M W; Kündig T M; Sambhara S R; Narendran A; Arabian A; Wakeham A; Paige C J; Zinkernagel R M
Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4.
Nature 1991;353(6340):180-4.
1991: Zinkernagel R M; Pircher H P; Ohashi P; Oehen S; Odermatt B; Mak T; Arnheiter H; Bürki K; Hengartner H
T and B cell tolerance and responses to viral antigens in transgenic mice: implications for the pathogenesis of autoimmune versus immunopathological disease.
Immunological reviews 1991;122():133-71.
1991: Battegay M; Cooper S; Althage A; Bänziger J; Hengartner H; Zinkernagel R M
Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates.
Journal of virological methods 1991;33(1-2):191-8.
1991: Leist T P; Meager A; Exley T; Zinkernagel R M
Evidence for a role of IFN gamma in control of Listeria monocytogenes in T cell deficient mice.
Experientia 1991;47(6):630-2.
1991: Pircher H; Rohrer U H; Moskophidis D; Zinkernagel R M; Hengartner H
Lower receptor avidity required for thymic clonal deletion than for effector T-cell function.
Nature 1991;351(6326):482-5.
1991: Oehen S; Hengartner H; Zinkernagel R
Recombinant vaccines.
Lancet 1991;337(8756):1542.
1991: Schulz M; Aichele P; Schneider R; Hansen T H; Zinkernagel R M; Hengartner H
Major histocompatibility complex binding and T cell recognition of a viral nonapeptide containing a minimal tetrapeptide.
European journal of immunology 1991;21(5):1181-5.
1991: Ohashi P S; Oehen S; Buerki K; Pircher H; Ohashi C T; Odermatt B; Malissen B; Zinkernagel R M; Hengartner H
Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice.
Cell 1991;65(2):305-17.
1991: Moskophidis D; Frei K; Löhler J; Fontana A; Zinkernagel R M
Production of random classes of immunoglobulins in brain tissue during persistent viral infection paralleled by secretion of interleukin-6 (IL-6) but not IL-4, IL-5, and gamma interferon.
Journal of virology 1991;65(3):1364-9.
1991: Titus R G; Müller I; Kimsey P; Cerny A; Behin R; Zinkernagel R M; Louis J A
Exacerbation of experimental murine cutaneous leishmaniasis with CD4+ Leishmania major-specific T cell lines or clones which secrete interferon-gamma and mediate parasite-specific delayed-type hypersensitivity.
European journal of immunology 1991;21(3):559-67.
1991: Schulz M; Zinkernagel R M; Hengartner H
Peptide-induced antiviral protection by cytotoxic T cells.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(3):991-3.
1991: Rüttner B; Hauser T; Leist T P; Zinkernagel R M
Absence of effects of thymopentin on murine host resistance to Listeria monocytogenes.
Thymus 1991;17(1):1-10.
1991: Speiser D E; Brändle R; Lees R K; Schneider R; Zinkernagel R M; MacDonald H R
Neonatal tolerance to MIs-1a determinants: deletion or anergy of V beta 6+ T lymphocytes depending upon MHC compatibility of neonatally injected cells.
International immunology 1991;3(2):127-34.
1991: Oehen S; Hengartner H; Zinkernagel R M
Vaccination for disease.
Science (New York, N.Y.) 1991;251(4990):195-8.
1991: Zinkernagel R M
[General immunologic fundamentals and an example of virally induced immunosuppression]
Verhandlungen der Deutschen Gesellschaft für Pathologie 1991;75():1-3.
1990: Roost H P; Charan S; Zinkernagel R M
Analysis of the kinetics of antiviral memory T help in vivo: characterization of short-lived cross-reactive T help.
European journal of immunology 1990;20(12):2547-54.
1990: Speiser D E; Zinkernagel R M
Thymic MHC class I gene regulation of susceptibility to lymphocytic choriomeningitis.
Thymus 1990;16(3-4):187-93.
1990: Speiser D E; Chvatchko Y; Zinkernagel R M; MacDonald H R
Distinct fates of self-specific T cells developing in irradiation bone marrow chimeras: clonal deletion, clonal anergy, or in vitro responsiveness to self-Mls-1a controlled by hemopoietic cells in the thymus.
The Journal of experimental medicine 1990;172(5):1305-14.
1990: Rüedi E; Hengartner H; Zinkernagel R M
Immunosuppression in mice by lymphocytic choriomeningitis virus infection: time dependence during primary and absence of effects on secondary antibody responses.
Cellular immunology 1990;130(2):501-12.
1990: Ohashi P S; Pircher H; Bürki K; Zinkernagel R M; Hengartner H
Distinct sequence of negative or positive selection implied by thymocyte T-cell receptor densities.
Nature 1990;346(6287):861-3.
1990: Pircher H; Moskophidis D; Rohrer U; Bürki K; Hengartner H; Zinkernagel R M
Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo.
Nature 1990;346(6285):629-33.
1990: Zinkernagel R M; Cooper S; Chambers J; Lazzarini R A; Hengartner H; Arnheiter H
Virus-induced autoantibody response to a transgenic viral antigen.
Nature 1990;345(6270):68-71.
1990: Stitz L; Schmitz C; Binder D; Zinkernagel R; Paoletti E; Becht H
Characterization and immunological properties of influenza A virus nucleoprotein (NP): cell-associated NP isolated from infected cells or viral NP expressed by vaccinia recombinant virus do not confer protection.
The Journal of general virology 1990;71 ( Pt 5)():1169-79.
1990: Aichele P; Hengartner H; Zinkernagel R M; Schulz M
Antiviral cytotoxic T cell response induced by in vivo priming with a free synthetic peptide.
The Journal of experimental medicine 1990;171(5):1815-20.
1990: Leist T P; Zinkernagel R M
Effects of treatment with IL-2 receptor specific monoclonal antibody in mice.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(7):2847.
1990: Speiser D E; Zürcher T; Ramseier H; Hengartner H; Staeheli P; Haller O; Zinkernagel R M
Nuclear myxovirus-resistance protein Mx is a minor histocompatibility antigen.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(5):2021-5.
1990: Leist T P; Zinkernagel R M
Treatment with anti-tumor necrosis factor alpha does not influence the immune pathological response against lymphocytic choriomeningitis virus.
Cytokine 1990;2(1):29-34.
1990: Cerny A; Hügin A W; Hardy R R; Hayakawa K; Zinkernagel R M; Makino M; Morse H C
B cells are required for induction of T cell abnormalities in a murine retrovirus-induced immunodeficiency syndrome.
The Journal of experimental medicine 1990;171(1):315-20.
1990: Kohler M; Rüttner B; Cooper S; Hengartner H; Zinkernagel R M
Enhanced tumor susceptibility of immunocompetent mice infected with lymphocytic choriomeningitis virus.
Cancer immunology, immunotherapy : CII 1990;32(2):117-24.
1990: Zinkernagel R M
Antiviral T-cell memory?
Current topics in microbiology and immunology 1990;159():65-77.
1990: Hauser T; Frei K; Zinkernagel R M; Leist T P
Role of tumor necrosis factor in Listeria resistance of nude mice.
Medical microbiology and immunology 1990;179(2):95-104.
1989: Leist T P; Kohler M; Zinkernagel R M
Impaired generation of anti-viral cytotoxicity against lymphocytic choriomeningitis and vaccinia virus in mice treated with CD4-specific monoclonal antibody.
Scandinavian journal of immunology 1989;30(6):679-86.
1989: Speiser D E; Lees R K; Hengartner H; Zinkernagel R M; MacDonald H R
Positive and negative selection of T cell receptor V beta domains controlled by distinct cell populations in the thymus.
The Journal of experimental medicine 1989;170(6):2165-70.
1989: Ohashi P S; Pircher H; Mak T W; Bürki K; Zinkernagel R M; Hengartner H
Ontogeny and selection of the T cell repertoire in transgenic mice.
Seminars in immunology 1989;1(2):95-104.
1989: Fontana A; Frei K; Bodmer S; Hofer E; Schreier M H; Palladino M A; Zinkernagel R M
Transforming growth factor-beta inhibits the generation of cytotoxic T cells in virus-infected mice.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(10):3230-4.
1989: Pircher H; Bürki K; Lang R; Hengartner H; Zinkernagel R M
Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen.
Nature 1989;342(6249):559-61.
1989: Schulz M; Aichele P; Vollenweider M; Bobe F W; Cardinaux F; Hengartner H; Zinkernagel R M
Major histocompatibility complex--dependent T cell epitopes of lymphocytic choriomeningitis virus nucleoprotein and their protective capacity against viral disease.
European journal of immunology 1989;19(9):1657-67.
1989: Speiser D E; Schneider R; Hengartner H; MacDonald H R; Zinkernagel R M
Clonal deletion of self-reactive T cells in irradiation bone marrow chimeras and neonatally tolerant mice. Evidence for intercellular transfer of Mlsa.
The Journal of experimental medicine 1989;170(2):595-600.
1989: Leist T; Althage A; Haenseler E; Hengartner H; Zinkernagel R M
Major histocompatibility complex-linked susceptibility or resistance to disease caused by a noncytopathic virus varies with the disease parameter evaluated.
The Journal of experimental medicine 1989;170(1):269-77.
1989: Müller C; Kägi D; Aebischer T; Odermatt B; Held W; Podack E R; Zinkernagel R M; Hengartner H
Detection of perforin and granzyme A mRNA in infiltrating cells during infection of mice with lymphocytic choriomeningitis virus.
European journal of immunology 1989;19(7):1253-9.
1989: Leist T P; Kohler M; Eppler M; Zinkernagel R M
Effects of treatment with IL-2 receptor specific monoclonal antibody in mice. Inhibition of cytotoxic T cell responses but not of T help.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(2):628-32.
1989: Leist T P; Eppler M; Zinkernagel R M
Enhanced virus replication and inhibition of lymphocytic choriomeningitis virus disease in anti-gamma interferon-treated mice.
Journal of virology 1989;63(6):2813-9.
1989: Schneider R; Lees R K; Pedrazzini T; Zinkernagel R M; Hengartner H; MacDonald H R
Postnatal disappearance of self-reactive (V beta 6+) cells from the thymus of Mlsa mice. Implications for T cell development and autoimmunity.
The Journal of experimental medicine 1989;169(6):2149-58.
1989: Rüedi E; Sykes M; Ildstad S T; Chester C H; Althage A; Hengartner H; Sachs D H; Zinkernagel R M
Antiviral T cell competence and restriction specificity of mixed allogeneic (P1 + P2----P1) irradiation chimeras.
Cellular immunology 1989;121(1):185-95.
1989: Frei K; Malipiero U V; Leist T P; Zinkernagel R M; Schwab M E; Fontana A
On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases.
European journal of immunology 1989;19(4):689-94.
1989: Pircher H; Mak T W; Lang R; Ballhausen W; Rüedi E; Hengartner H; Zinkernagel R M; Bürki K
T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice.
The EMBO journal 1989;8(3):719-27.
1989: Hany M; Oehen S; Schulz M; Hengartner H; Mackett M; Bishop D H; Overton H; Zinkernagel R M
Anti-viral protection and prevention of lymphocytic choriomeningitis or of the local footpad swelling reaction in mice by immunization with vaccinia-recombinant virus expressing LCMV-WE nucleoprotein or glycoprotein.
European journal of immunology 1989;19(3):417-24.
1989: MacDonald H R; Glasebrook A L; Schneider R; Lees R K; Pircher H; Pedrazzini T; Kanagawa O; Nicolas J F; Howe R C; Zinkernagel R M
T-cell reactivity and tolerance to Mlsa-encoded antigens.
Immunological reviews 1989;107():89-108.
1989: Zinkernagel R M; Pircher H P; Schulz M; Leist T; Oehen S; Hengartner H
Reactivity and tolerance of virus-specific T cells.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 2():843-51.
1989: Schneider R; Lees R; Pedrazzini T; Odermatt B; Speiser D E; Zinkernagel R M; Hengartner H; MacDonald H R
Fate of potentially self-reactive T cells in neonatal mice: analysis of V beta 6+ T cells in Mlsa mice.
Thymus 1989;13(1-2):35-43.
1989: Speiser D E; Kolb E; Schneider R; Pircher H; Hengartner H; MacDonald H R; Zinkernagel R M
Tolerance to Mlsa by clonal deletion of V beta 6+ T cells in bone marrow and thymus chimeras.
Thymus 1989;13(1-2):27-33.
1989: MacDonald H R; Speiser D; Lees R; Schneider R; Zinkernagel R M; Hengartner H
Positive and negative selection of the T-cell antigen receptor repertoire in nontransgenic mice.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 1():129-33.
1988: MacDonald H R; Lees R K; Schneider R; Zinkernagel R M; Hengartner H
Positive selection of CD4+ thymocytes controlled by MHC class II gene products.
Nature 1988;336(6198):471-3.
1988: Zinkernagel R M
Virus-triggered AIDS: a T-cell-mediated immunopathology?
Immunology today 1988;9(12):370-2.
1988: Cerny A; Zinkernagel R M; Groscurth P
Development of follicular dendritic cells in lymph nodes of B-cell-depleted mice.
Cell and tissue research 1988;254(2):449-54.
1988: Hengartner H; Odermatt B; Schneider R; Schreyer M; Wälle G; MacDonald H R; Zinkernagel R M
Deletion of self-reactive T cells before entry into the thymus medulla.
Nature 1988;336(6197):388-90.
1988: Cottagnoud P; Neftel K A; Hany M; Zinkernagel R M
Inhibition of HSV-1 and vaccinia virus replication by cephalosporin derivatives.
Antiviral research 1988;10(1-3):59-70.
1988: Baenziger J; Hengartner H; Zinkernagel R M; Groscurth P
Distinct patterns of virus-specific T cell-mediated cytolysis of transformed versus primary target cells.
Scandinavian journal of immunology 1988;28(4):411-23.
1988: Manzionna M M; Seger R A; Wahn V; Zinkernagel R M; Böcker A; Hitzig W H
Absence of complement receptor type 3 and lymphocyte function antigen 1 causing deficient phagocyte and lymphocyte functions.
European journal of pediatrics 1988;148(1):58-61.
1988: Herrmann P; Schreier M H; Bazin H; Zinkernagel R M; Cerny A
Delayed type hypersensitivity (DTH) in anti-IgM-treated B cell-depleted mice: analysis of induction and effector phase.
Immunobiology 1988;177(4-5):382-9.
1988: Zinkernagel R M; Rüedi E; Althage A; Hengartner H; Reimann G
Thymic selection of H-2-incompatible bone marrow cells in SCID mice. Differences in T help for induction of B cell IgG responses versus cytotoxic T cells.
The Journal of experimental medicine 1988;168(3):1187-92.
1988: Leist T P; Heuchel R; Zinkernagel R M
Increased bactericidal macrophage activity induced by immunological stimuli is dependent on interferon (IFN)-gamma. Interference of anti-IFN-gamma but not anti-IFN-alpha/beta with modulation of macrophage activity caused by lymphocytic choriomeningitis virus infection or systemic graft-vs.-host reactions.
European journal of immunology 1988;18(8):1295-8.
1988: MacDonald H R; Howe R C; Pedrazzini T; Lees R K; Budd R C; Schneider R; Liao N S; Zinkernagel R M; Louis J A; Raulet D H
T-cell lineages, repertoire selection and tolerance induction.
Immunological reviews 1988;104():157-82.
1988: Frei K; Leist T P; Meager A; Gallo P; Leppert D; Zinkernagel R M; Fontana A
Production of B cell stimulatory factor-2 and interferon gamma in the central nervous system during viral meningitis and encephalitis. Evaluation in a murine model infection and in patients.
The Journal of experimental medicine 1988;168(1):449-53.
1988: Cerny A; Ramseier H; Bazin H; Zinkernagel R M
Unimpaired first-set and second-set skin graft rejection in agammaglobulinemic mice.
Transplantation 1988;45(6):1111-3.
1988: MacDonald H R; Pedrazzini T; Schneider R; Louis J A; Zinkernagel R M; Hengartner H
Intrathymic elimination of Mlsa-reactive (V beta 6+) cells during neonatal tolerance induction to Mlsa-encoded antigens.
The Journal of experimental medicine 1988;167(6):2005-10.
1988: Leist T P; Frei K; Kam-Hansen S; Zinkernagel R M; Fontana A
Tumor necrosis factor alpha in cerebrospinal fluid during bacterial, but not viral, meningitis. Evaluation in murine model infections and in patients.
The Journal of experimental medicine 1988;167(5):1743-8.
1988: Cerny A; Sutter S; Bazin H; Hengartner H; Zinkernagel R M
Clearance of lymphocytic choriomeningitis virus in antibody- and B-cell-deprived mice.
Journal of virology 1988;62(5):1803-7.
1988: Leist T P; Rüedi E; Zinkernagel R M
Virus-triggered immune suppression in mice caused by virus-specific cytotoxic T cells.
The Journal of experimental medicine 1988;167(5):1749-54.
1988: Roost H; Charan S; Gobet R; Rüedi E; Hengartner H; Althage A; Zinkernagel R M
An acquired immune suppression in mice caused by infection with lymphocytic choriomeningitis virus.
European journal of immunology 1988;18(4):511-8.
1988: MacDonald H R; Schneider R; Lees R K; Howe R C; Acha-Orbea H; Festenstein H; Zinkernagel R M; Hengartner H
T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens.
Nature 1988;332(6159):40-5.
1988: Stitz L; Hengartner H; Althage A; Zinkernagel R M
An easy and rapid method to screen large numbers of antibodies against internal cellular determinants.
Journal of immunological methods 1988;106(2):211-6.
1988: Cerny A; Hügin A W; Bazin H; Sutter S; Hengartner H; Zinkernagel R M
Anti-Listeria monocytogenes immunity in mu-suppressed mice: a comparison of treatment with conventional hyperimmune rabbit anti-mouse IgM and affinity-purified, monoclonal rat anti-mouse IgM.
Medical microbiology and immunology 1988;177(3):123-31.
1988: Schulz M; Lienhard G; Rupp F; Zinkernagel R M; Hengartner H
Expression of T cell receptor gamma-chain in murine cytotoxic T cells: analysis of a highly transcribed nonrearranged gene cluster.
Experimental cell biology 1988;56(4):181-9.
1988: Gobet R; Cerny A; Rüedi E; Hengartner H; Zinkernagel R M
The role of antibodies in natural and acquired resistance of mice to vesicular stomatitis virus.
Experimental cell biology 1988;56(4):175-80.
1987: Pircher H; Michalopoulos E E; Iwamoto A; Ohashi P S; Baenziger J; Hengartner H; Zinkernagel R M; Mak T W
Molecular analysis of the antigen receptor of virus-specific cytotoxic T cells and identification of a new V alpha family.
European journal of immunology 1987;17(12):1843-6.
1987: Leist T P; Aguet M; Hässig M; Pevear D C; Pfau C J; Zinkernagel R M
Lack of correlation between serum titres of interferon alpha, beta, natural killer cell activity and clinical susceptibility in mice infected with two isolates of lymphocytic choriomeningitis virus.
The Journal of general virology 1987;68 ( Pt 8)():2213-8.
1987: Charan S; Hengartner H; Zinkernagel R M
Antibodies against the two serotypes of vesicular stomatitis virus measured by enzyme-linked immunosorbent assay: immunodominance of serotype-specific determinants and induction of asymmetrically cross-reactive antibodies.
Journal of virology 1987;61(8):2509-14.
1987: Pestalozzi B; Stitz L; Zinkernagel R M
Monoclonal antibodies against viral determinants are not restricted to the K/D end of the major histocompatibility complex.
The Journal of experimental medicine 1987;166(1):295-9.
1987: Cerny A; Starobinski M; Hügin A W; Sutter S; Zinkernagel R M; Izui S
Treatment with high doses of anti-IgM prevents, but with lower doses accelerates autoimmune disease in (NZW x BXSB)F1 hybrid mice.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(12):4222-8.
1987: Leist T P; Cobbold S P; Waldmann H; Aguet M; Zinkernagel R M
Functional analysis of T lymphocyte subsets in antiviral host defense.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(7):2278-81.
1987: Pircher H; Baenziger J; Schilham M; Sado T; Kamisaku H; Hengartner H; Zinkernagel R M
Characterization of virus-specific cytotoxic T cell clones from allogeneic bone marrow chimeras.
European journal of immunology 1987;17(2):159-66.
1987: Rupp F; Brecher J; Giedlin M A; Mosmann T; Zinkernagel R M; Hengartner H; Joho R H
T-cell antigen receptors with identical variable regions but different diversity and joining region gene segments have distinct specificities but cross-reactive idiotypes.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(1):219-22.
1986: Schilham M W; Lang R; Benner R; Zinkernagel R M; Hengartner H
Characterization of an Lyt-2+ alloreactive cytotoxic T cell clone specific for H-2Db that cross-reacts with I-Ek.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(9):2748-54.
1986: Rosenthal K L; Zinkernagel R M; Hengartner H; Groscurth P; Dennert G; Takayesu D; Prevec L
Persistence of vesicular stomatitis virus in cloned interleukin-2-dependent natural killer cell lines.
Journal of virology 1986;60(2):539-47.
1986: Cerny A; Heusser C; Sutter S; Huegin A W; Bazin H; Hengartner H; Zinkernagel R M
Generation of agammaglobulinaemic mice by prenatal and postnatal exposure to polyclonal or monoclonal anti-IgM antibodies.
Scandinavian journal of immunology 1986;24(4):437-45.
1986: Zinkernagel R M; Haenseler E; Leist T; Cerny A; Hengartner H; Althage A
T cell-mediated hepatitis in mice infected with lymphocytic choriomeningitis virus. Liver cell destruction by H-2 class I-restricted virus-specific cytotoxic T cells as a physiological correlate of the 51Cr-release assay?
The Journal of experimental medicine 1986;164(4):1075-92.
1986: Zinkernagel R M
Biological role of major transplantation antigens in T cell self-recognition.
Experientia 1986;42(9):970-2.
1986: Cerny A; Huegin A W; Sutter S; Bazin H; Hengartner H H; Zinkernagel R M
Immunity to lymphocytic choriomeningitis virus in B cell-depleted mice: evidence for B cell and antibody-independent protection by memory T cells.
European journal of immunology 1986;16(8):913-7.
1986: Fontana A; Erb P; Pircher H; Zinkernagel R; Weber E; Fierz W
Astrocytes as antigen-presenting cells. Part II: Unlike H-2K-dependent cytotoxic T cells, H-2Ia-restricted T cells are only stimulated in the presence of interferon-gamma.
Journal of neuroimmunology 1986;12(1):15-28.
1986: Stitz L; Baenziger J; Pircher H; Hengartner H; Zinkernagel R M
Effect of rabbit anti-asialo GM1 treatment in vivo or with anti-asialo GM1 plus complement in vitro on cytotoxic T cell activities.
Journal of immunology (Baltimore, Md. : 1950) 1986;136(12):4674-80.
1986: Rupp F; Frech G; Hengartner H; Zinkernagel R M; Joho R
No functional gamma-chain transcripts detected in an alloreactive cytotoxic T-cell clone.
Nature 1986;321(6073):876-8.
1986: Hügin A W; Cerny A; Wrann M; Hengartner H; Zinkernagel R M
Effect of cyclosporin A on immunity to Listeria monocytogenes.
Infection and immunity 1986;52(1):12-7.
1986: Zinkernagel R M
Major histocompatibility gene complex-disease associations may reflect T cell-mediated immunopathology.
European journal of clinical investigation 1986;16(2):101-5.
1986: Baenziger J; Hengartner H; Zinkernagel R M; Cole G A
Induction or prevention of immunopathological disease by cloned cytotoxic T cell lines specific for lymphocytic choriomeningitis virus.
European journal of immunology 1986;16(4):387-93.
1986: Gupta S C; Hengartner H; Zinkernagel R M
Primary antibody responses to a well-defined and unique hapten are not enhanced by preimmunization with carrier: analysis in a viral model.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(8):2604-8.
1986: Charan S; Zinkernagel R M
Antibody mediated suppression of secondary IgM response in nude mice against vesicular stomatitis virus.
Journal of immunology (Baltimore, Md. : 1950) 1986;136(8):3057-61.
1986: Charan S; Huegin A W; Cerny A; Hengartner H; Zinkernagel R M
Effects of cyclosporin A on humoral immune response and resistance against vesicular stomatitis virus in mice.
Journal of virology 1986;57(3):1139-44.
1986: Pircher H; Groscurth P; Baumhütter S; Aguet M; Zinkernagel R M; Hengartner H
A monoclonal antibody against altered LFA-1 induces proliferation and lymphokine release of cloned T cells.
European journal of immunology 1986;16(2):172-81.
1986: Huegin A W; Cerny A; Zinkernagel R M; Neftel K A
Suppressive effects of B-lactam-antibiotics on in vitro generation of cytotoxic T-cells.
International journal of immunopharmacology 1986;8(7):723-9.
1986: Zinkernagel R M; Leist T; Hengartner H; Pestalozzi B; Stitz L
Studies on immunity to lymphocytic choriomeningitis virus.
Medical microbiology and immunology 1986;175(2-3):209-11.
1986: Baenziger J; Hengartner H; Zinkernagel R M
Cloned cytotoxic T cells specific for lymphocytic choriomeningitis virus induce acute disease and primary footpad swelling in infected mice.
Medical microbiology and immunology 1986;175(2-3):201-3.
1985: Zinkernagel R M; Leist T; Hengartner H; Althage A
Susceptibility to lymphocytic choriomeningitis virus isolates correlates directly with early and high cytotoxic T cell activity, as well as with footpad swelling reaction, and all three are regulated by H-2D.
The Journal of experimental medicine 1985;162(6):2125-41.
1985: Zinkernagel R M; Pfau C J; Hengartner H; Althage A
Susceptibility to murine lymphocytic choriomeningitis maps to class I MHC genes--a model for MHC/disease associations.
Nature 1985;316(6031):814-7.
1985: Stitz L; Huang R T; Hengartner H; Rott R; Zinkernagel R M
Cytotoxic T cell lysis of target cells fused with liposomes containing influenza virus haemagglutinin and neuraminidase.
The Journal of general virology 1985;66 ( Pt 6)():1333-9.
1985: Rupp F; Acha-Orbea H; Hengartner H; Zinkernagel R; Joho R
Identical V beta T-cell receptor genes used in alloreactive cytotoxic and antigen plus I-A specific helper T cells.
Nature 1985;315(6018):425-7.
1985: Pircher H; Zinkernagel R M; Hengartner H
Inhibition of hapten-specific cytotoxic T cell recognition by monoclonal anti-hapten antibodies.
European journal of immunology 1985;15(3):228-35.
1985: Huegin A W; Cerny A; Hengartner H; Zinkernagel R M
Suppression by cyclosporin A of murine T-cell-mediated immunity against viruses in vivo and in vitro.
Cellular immunology 1985;90(2):464-73.
1985: Zinkernagel R M; Hengartner H; Stitz L
On the role of viruses in the evolution of immune responses.
British medical bulletin 1985;41(1):92-7.
1985: Stitz L; Althage A; Hengartner H; Zinkernagel R
Natural killer cells vs cytotoxic T cells in the peripheral blood of virus-infected mice.
Journal of immunology (Baltimore, Md. : 1950) 1985;134(1):598-602.
1985: Acha-Orbea H; Zinkernagel R M; Hengartner H
Cytotoxic T cell clone-specific monoclonal antibodies used to select clonotypic antigen-specific cytotoxic T cells.
European journal of immunology 1985;15(1):31-6.
1985: Cerny A; Hügin A W; Sutter S; Heusser C H; Bos N; Izui S; Hengartner H; Zinkernagel R M
Suppression of B cell development and antibody responses in mice with polyclonal rabbit and monoclonal rat anti-IgM antibodies. I. Characterization of the suppressed state.
Experimental cell biology 1985;53(6):301-13.
1984: Stitz L; Zinkernagel R M
Immunological tolerance to a non-cytopathic virus is not inheritable in mice.
Immunology 1984;52(2):205-9.
1984: Pestalozzi B C; Zinkernagel R M
Graft-versus-host reactions in F1 hybrid mice: MHC-restriction-independent generalized depression of virus-specific cytotoxic T cell response.
Immunobiology 1984;166(3):308-17.
1984: Zinkernagel R M; Sado T; Althage A; Kamisaku H
Anti-viral immune response of allogeneic irradiation bone marrow chimeras: cytotoxic T cell responsiveness depends upon H-2 combination and infectious agent.
European journal of immunology 1984;14(1):14-23.
1984: Stitz L; Zinkernagel R; Balch C M; Bolhuis R L; Balner H
Immune response against vaccinia virus in rhesus monkeys: no evidence for primary MHC-restricted cytolytic T cells.
Experimental cell biology 1984;52(4):237-50.
1983: Brenan M; Zinkernagel R M
Influence of one virus infection on a second concurrent primary in vivo antiviral cytotoxic T-cell response.
Infection and immunity 1983;41(2):470-5.
1983: Rosenthal K L; Oldstone M B; Hengartner H; Zinkernagel R M
Specificity of in vitro cytotoxic T cell clones directed against vesicular stomatitis virus.
Journal of immunology (Baltimore, Md. : 1950) 1983;131(1):475-8.
1983: Maestroni G J; Pierpaoli W; Zinkernagel R M
Allogeneic H-2d leads to H-2b irradiation bone marrow chimeras: a) failure to transfer chimerism adoptively and b) immune reactivity of immunocompetent lymphocytes adoptively transferred to chimeras.
Immunobiology 1983;164(5):417-29.
1983: Zinkernagel R M
Protection and damage by immunity to intracellular parasites.
Ethiopian medical journal 1983;21(2):127-31.
1983: Zinkernagel R M; Bürki K; Cottier F; de Kossodo S; Althage A; Illmensee K
Thymus differentiation and T-cell specificity in nu/nu +/+ mouse aggregation chimaeras.
The EMBO journal 1983;2(10):1665-72.
1982: Zinkernagel R M
Selection of restriction specificities of virus-specific cytotoxic T cells in the thymus: no evidence for a crucial role of antigen-presenting cells.
The Journal of experimental medicine 1982;156(6):1842-7.
1982: Zinkernagel R M
[Transplantation antigens: biological function and role as disease determinants]
Die Naturwissenschaften 1982;69(11):537-8.
1982: Maestroni G J; Pierpaoli W; Zinkernagel R M
Immunoreactivity of long lived H-2 incompatible irradiation chimeras (H-2d leads to H-2b).
Immunology 1982;46(2):253-60.
1982: Zinkernagel R M
Differentiation of T cells: thymic selection of specificity for self.
Progress in clinical and biological research 1982;85 Pt A():427-34.
1982: Zinkernagel R M
How to escape immune surveillance?
Springer seminars in immunopathology 1982;5(1):107-12.
1982: Zinkernagel R M; Althage A
Assessment of some genetic non-MHC differences with GVHR-induced anti-listeria activity of macrophages.
Immunogenetics 1982;16(6):571-6.
1981: Zinkernagel R M; Callahan G N
Low responsiveness to Dk or Db plus vaccinia virus or to Kk plus lymphocytic choriomeningitis virus assessed by availability of D or K products.
Tissue antigens 1981;17(5):507-17.
1981: Kreeb G; Creighton W D; Zinkernagel R M
Suppression of the generation of secondary virus-specific proliferative and cytotoxic T lymphocytes by suppressor cells induced during primary anti-viral sensitization in vitro.
Immunology 1981;43(1):47-55.
1981: Zinkernagel R M
Restriction specificity of virus-specific cytotoxic T cells from thymectomised irradiated bone marrow chimeras reconstituted with thymus grafts.
Thymus 1981;2(6):321-7.
1981: Kreeb G; Zinkernagel R M
Murine antiviral proliferative and cytotoxic T-cell responses: specificities and role of the H-21 region.
Transplantation proceedings 1981;13(1 Pt 2):979-81.
1981: Doherty P C; Zinkernagel R M; Ramshaw I A; Grant C K
Rejection of allogeneic tumor cells growing in mouse cerebrospinal fluid. Functional analysis of the inflammatory process.
Journal of neuroimmunology 1981;1(1):93-9.
1981: Rosenthal K L; Zinkernagel R M
Inability of mice to generate cytotoxic T lymphocytes to vesicular stomatitis virus restricted to H-2Kk or H-2Dk.
Journal of immunology (Baltimore, Md. : 1950) 1981;126(2):446-51.
1981: Zinkernagel R M
[Role of virus-induced cell-mediated immune reactions]
Verhandlungen der Deutschen Gesellschaft für Pathologie 1981;65():11-4.
1981: Zinkernagel R M; Rosenthal K L
Experiments and speculation on antiviral specificity of T and B cells.
Immunological reviews 1981;58():131-55.
1980: Kreeb G; Zinkernagel R M
Role of the H-2I region in the generation of an antiviral cytotoxic T-cell response in vitro.
Cellular immunology 1980;53(2):285-97.
1980: Kreeb G; Zinkernagel R M
Virus-specific proliferative T-cell responses: parameters and specificity.
Cellular immunology 1980;53(2):267-84.
1980: Zinkernagel R M; Althage A; Callahan G; Welsh R M
On the immunocompetence of H-2 incompatible irradiation bone marrow chimeras.
Journal of immunology (Baltimore, Md. : 1950) 1980;124(5):2356-65.
1980: Rosenthal K L; Zinkernagel R M
Cross-reactive cytotoxic T cells to serologically distinct vesicular stomatitis virus.
Journal of immunology (Baltimore, Md. : 1950) 1980;124(5):2301-8.
1980: Zinkernagel R M; Kreeb G; Althage A
Lymphohemopoietic origin of the immunogenic, virus-antigen-presenting cells triggering anti-viral T-cell responses.
Clinical immunology and immunopathology 1980;15(3):565-76.
1980: Zinkernagel R M; Althage A; Waterfield E; Kindred B; Welsh R M; Callahan G; Pincetl P
Restriction specificities, alloreactivity, and allotolerance expressed by T cells from nude mice reconstituted with H-2-compatible or -incompatible thymus grafts.
The Journal of experimental medicine 1980;151(2):376-99.
1979: Zinkernagel R M; Althage A; Callahan G
Thymic reconstitution of nude F1 mice with one or both parental thymus grafts.
The Journal of experimental medicine 1979;150(3):693-7.
1979: Geiger B; Rosenthal K L; Klein J; Zinkernagel R M; Singer S J
Selective and unidirectional membrane redistribution of an H-2 antigen with an antibody-clustered viral antigen: relationship to mechanisms of cytotoxic T-cell interactions.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(9):4603-7.
1979: Creighton W D; Zinkernagel R M; Dixon F J
T cell-mediated immune responses of lupus-prone BXSB mice and other murine strains.
Clinical and experimental immunology 1979;37(2):181-9.
1979: Zinkernagel R M; Althage A
Search for suppression of T cells specific for the second nonhost H-2 haplotype in F1 leads to P irradiation bone marrow chimeras.
Journal of immunology (Baltimore, Md. : 1950) 1979;122(5):1742-9.
1979: Croker B P; Zinkernagel R M; Dixon F J
Natural cytotoxic cells in NZB mice: spontaneous in vivo and in vitro primed activity and structural characteristics.
Clinical immunology and immunopathology 1979;12(4):410-24.
1979: Zinkernagel R M
Association of disease susceptibility to major histocompatibility antigens.
Transplantation proceedings 1979;11(1):624-7.
1979: Welsh R M; Zinkernagel R M; Hallenbeck L A
Cytotoxic cells induced during lymphocytic choriomeningitis virus infection of mice. II. "Specificities" of the natural killer cells.
Journal of immunology (Baltimore, Md. : 1950) 1979;122(2):475-81.
1979: Zinkernagel R M
Review: cellular immune responses to intracellular parasites: role of the major histocompatibility gene complex and thymus in determining immune responsiveness and susceptibility to disease.
Parasite immunology 1979;1(2):91-109.
1979: Zinkernagel R M
Associations between major histocompatibility antigens and susceptibility to disease.
Annual review of microbiology 1979;33():201-13.
1979: Zinkernagel R M; Doherty P C
MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness.
Advances in immunology 1979;27():51-177.
1978: Perrin L H; Reynolds D; Zinkernagel R; Oldstone M B
Generation of virus-specific cytolytic activity in human peripheral lymphocytes after vaccination with vaccinia virus and measles virus.
Medical microbiology and immunology 1978;166(1-4):71-9.
1978: Zinkernagel R M; Althage A; Cooper S; Callahan G; Klein J
In irradiation chimeras, K or D regions of the chimeric host, not of the donor lymphocytes, determine immune responsiveness of antiviral cytotoxic T cells.
The Journal of experimental medicine 1978;148(3):805-10.
1978: Zinkernagel R M; Althage A; Cooper S; Kreeb G; Klein P A; Sefton B; Flaherty L; Stimpfling J; Shreffler D; Klein J
Ir-genes in H-2 regulate generation of anti-viral cytotoxic T cells. Mapping to K or D and dominance of unresponsiveness.
The Journal of experimental medicine 1978;148(2):592-606.
1978: Zinkernagel R M; Althage A; Holland J
Target antigens for H-2-restricted vesicular stomatitis virus-specific cytotoxic T cells.
Journal of immunology (Baltimore, Md. : 1950) 1978;121(2):744-8.
1978: Zinkernagel R M
Major transplantation antigens in T cell-mediated immunity: a comparison of the transplantation reaction with antiviral immunity.
Federation proceedings 1978;37(10):2379-84.
1978: Zinkernagel R M
Major transplantation antigens in host responses to infection.
Hospital practice 1978;13(7):83-92.
1978: Zinkernagel R M; Althage A; Jensen F; Streilein J W; Duncan W R
Cell-mediated immunity to viruses in hamsters.
Federation proceedings 1978;37(7):2078-81.
1978: Zinkernagel R M; Callahan G N; Althage A; Cooper S; Streilein J W; Klein J
The lymphoreticular system in triggering virus plus self-specific cytotoxic T cells: evidence for T help.
The Journal of experimental medicine 1978;147(3):897-911.
1978: Zinkernagel R M; Callahan G N; Althage A; Cooper S; Klein P A; Klein J
On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?
The Journal of experimental medicine 1978;147(3):882-96.
1978: Zinkernagel R M; Callahan G N; Klein J; Dennert G
Cytotoxic T cells learn specificity for self H-2 during differentiation in the thymus.
Nature 1978;271(5642):251-3.
1978: Zinkernagel R M
Thymus function and reconstitution of immunodeficiency.
The New England journal of medicine 1978;298(4):222.
1978: Zinkernagel R M
Immunologic cellular effector mechanisms as examples of cellular interactions.
Birth defects original article series 1978;14(2):343-8.
1978: Zinkernagel R M; Adler B; Holland J J
Cell-mediated immunity to vesicular stomatitis virus infections in mice.
Experimental cell biology 1978;46(1-2):53-70.
1978: Zinkernagel R M
Thymus and lymphohemopoietic cells: their role in T cell maturation in selection of T cells' H-2-restriction-specificity and in H-2 linked Ir gene control.
Immunological reviews 1978;42():224-70.
1978: Zinkernagel R M
Speculations on the role of major transplantation antigens in cell-mediated immunity against intracellular parasites.
Current topics in microbiology and immunology 1978;82():113-38.
1977: Zinkernagel R M
Role of the H-2 gene complex in cell-mediated immunity to infectious disease.
Transplantation proceedings 1977;9(4):1835-8.
1977: Zinkernagel R M; Althage A; Jensen F C
Cell-mediated immune response to lymphocytic choriomeningitis and vaccinia virus in rats.
Journal of immunology (Baltimore, Md. : 1950) 1977;119(4):1242-7.
1977: Perrin L H; Zinkernagel R M; Oldstone M B
Immune response in humans after vaccination with vaccinia virus: generation of a virus-specific cytotoxic activity by human peripheral lymphocytes.
The Journal of experimental medicine 1977;146(4):949-69.
1977: Dunlop M B; Doherty P C; Zinkernagel R M; Blanden R V
Cytotoxic T cell response to lymphocytic choriomeningitis virus. Properties of precursors of effector T cells, primary effector T cells and memory T cells in vitro and in vivo.
Immunology 1977;33(3):361-8.
1977: Welsh R M; Zinkernagel R M
Heterospecific cytotoxic cell activity induced during the first three days of acute lymphocytic choriomeningitis virus infection in mice.
Nature 1977;268(5621):646-8.
1977: Zinkernagel R M; Dixon F J
Comparison of T cell-mediated immune responsiveness of NZB, (NZB x &NZW)F1 hybrid and other murine strains.
Clinical and experimental immunology 1977;29(1):110-21.
1977: Zinkernagel R M; Althage A; Adler B; Blanden R V; Davidson W F; Kees U; Dunlop M B; Shreffler D C
H-2 restriction of cell-mediated immunity to an intracellular bacterium: effector T cells are specific for Listeria antigen in association with H-21 region-coded self-markers.
The Journal of experimental medicine 1977;145(5):1353-67.
1977: Zinkernagel R M; Callahan G N; Streilein J W; Klein J
Neonatally tolerant mice fail to react against virus-infected tolerated cells.
Nature 1977;266(5605):837-9.
1977: Zinkernagel R M; Althage A
Antiviral protection by virus-immune cytotoxic T cells: infected target cells are lysed before infectious virus progeny is assembled.
The Journal of experimental medicine 1977;145(3):644-51.
1977: Zinkernagel R M; Doherty P C
The concept that surveillance of self is mediated via the same set of genes that determines recognition of allogenic cells.
Cold Spring Harbor symposia on quantitative biology 1977;41 Pt 2():505-10.
1977: Zinkernagel R M; Doherty P C
Major transplantation antigens, viruses, and specificity of surveillance T cells.
Contemporary topics in immunobiology 1977;7():179-220.
1976: Zinkernagel R M; Welsh R M
H-2 compatibility requirement for virus-specific T cell-mediated effector functions in vivo. I. Specificity of T cells conferring antiviral protection against lymphocytic choriomeningitis virus is associated with H-2K and H-2D.
Journal of immunology (Baltimore, Md. : 1950) 1976;117(5 Pt 1):1495-502.
1976: Zinkernagel R M; Oldstone M B
Cells that express viral antigens but lack H-2 determinants are not lysed by immune thymus-derived lymphocytes but are lysed by other antiviral immune attack mechanisms.
Proceedings of the National Academy of Sciences of the United States of America 1976;73(10):3666-70.
1976: Zinkernagel R M
H-2 restriction of virus-specific cytotoxicity across the H-2 barrier. Separate effector T-cell specificities are associated with self-H-2 and with the tolerated allogeneic H-2 in chimeras.
The Journal of experimental medicine 1976;144(4):933-45.
1976: Zinkernagel R M
H-2 restriction of virus-specific T-cell-mediated effector functions in vivo. II. Adoptive transfer of delayed-type hypersensitivity to murine lymphocytic choriomeningits virus is restriced by the K and D region of H-2.
The Journal of experimental medicine 1976;144(3):776-87.
1976: Zinkernagel R M; Dunlop M B; Blanden R V; Doherty P C; Shreffler D C
H-2 compatibility requirement for virus-specific T-cell-mediated cytolysis. Evaluation of the role of H-2I region and non-H-2 genes in regulating immune response.
The Journal of experimental medicine 1976;144(2):519-32.
1976: Dunlop M B; Doherty P C; Zinkernagel R M; Blanden R V
Secondary cytotoxic cell response to lymphocytic choriomeningitis virus II. Nature and specificity of effector cells.
Immunology 1976;31(2):181-6.
1976: Doherty P C; Dunlop M B; Parish C R; Zinkernagel R M
Inflammatory process in murine lymphocytic choriomeningitis is maximal in H-2K or H-2D compatible interactions.
Journal of immunology (Baltimore, Md. : 1950) 1976;117(1):187-90.
1976: Doherty P C; Zinkernagel R M
Specific immune lysis of paramyxovirus-infected cells by H-2-compatible thymus-derived lymphocytes.
Immunology 1976;31(1):27-32.
1976: Zinkernagel R M
Virus-specific T-cell-mediated cytotoxicity across the H-2 barrier to virus-altered alloantigen.
Nature 1976;261(5556):139-41.
1976: Zinkernagel R M
Cell-mediated immune response to Salmonella typhimurium infection in mice: development of nonspecific bactericidal activity against Listeria monocytogenes.
Infection and immunity 1976;13(4):1069-73.
1976: Zinkernagel R M
H-2 compatibility requirement for virus-specific T-cell-mediated cytolysis. The H-2K structure involved is coded by a single cistron defined by H-2Kb mutant mice.
The Journal of experimental medicine 1976;143(2):437-43.
1976: Zinkernagel R M
T helpers may be sensitized by antigen-specifically altered structures, which are coded by the I region of the H-2 gene complex.
Advances in experimental medicine and biology 1976;66():527-30.
1976: Zinkernagel R M; Doherty P C
Virus-immune cytotoxic T cells are sentized to by virus specifically altered structures coded for in H-2K or H-2D: a biological role for major histocompatibility antigens.
Advances in experimental medicine and biology 1976;66():387-9.
1976: Doherty P C; Blanden R V; Zinkernagel R M
Specificity of virus-immune effector T cells for H-2K or H-2D compatible interactions: implications for H-antigen diversity.
Transplantation reviews 1976;29():89-124.
1975: Globerson A; Zinkernagel R M; Umiel T
Proceedings: Immunosuppression by embryonic liver cells: a model for establishment of tolerance to self.
Israel journal of medical sciences 1975;11(12):1385-6.
1975: Zinkernagel R M; Colombini A
Passive oral immunization with bovine immunoglobulins: enterpathogenic Escherichia coli from infants and bovine anti-E. coli lactoserum assayed in the rabbit ileal loop model.
Medical microbiology and immunology 1975;162(1):1-7.
1975: Globerson A; Zinkernagel R M; Umiel T
Immunosuppression by embryonic liver cells.
Transplantation 1975;20(6):480-4.
1975: Zinkernagel R M; Dunlop M B; Doherty P C
Cytotoxic T cell activity is strain-specific in outbred mice infected with lymphocytic choriomeningitis virus.
Journal of immunology (Baltimore, Md. : 1950) 1975;115(6):1613-6.
1975: Zinkernagel R M; Doherty P C
Peritoneal macrophages as target cells for measuring virus-specific T cell mediated cytotoxicity in vitro.
Journal of immunological methods 1975;8(3):263-6.
1975: Zinkernagel R M; Doherty P C
Cortisone-resistant effector T cells in acute lymphocytic choriomeningitis and Listeria monocytogenes infection of mice.
The Australian journal of experimental biology and medical science 1975;53(4):297-303.
1975: Doherty P C; Zinkernagel R M
Enhanced immunological surveillance in mice heterozygous at the H-2 gene complex.
Nature 1975;256(5512):50-2.
1975: Zinkernagel R M; Pang T; Blanden R V
Effect of cell dose and dose of infectious agent on expression of protection against Listeria monocytogenes and Ectromelia virus in cell transfer models.
Infection and immunity 1975;11(6):1170-3.
1975: Doherty P C; Zinkernagel R M
A biological role for the major histocompatibility antigens.
Lancet 1975;1(7922):1406-9.
1975: Zinkernagel R M; Doherty P C
H-2 compatability requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. Different cytotoxic T-cell specificities are associated with structures coded for in H-2K or H-2D;.
The Journal of experimental medicine 1975;141(6):1427-36.
1975: Zinkernagel R M; Blanden R V
Macrophage activation in mice lacking thymus-derived (T) cells.
Experientia 1975;31(5):591-3.
1975: Blanden R V; Doherty P C; Dunlop M B; Gardner I D; Zinkernagel R M; David C S
Genes required for cytotoxicity against virus-infected target cells in K and D regions of H-2 complex.
Nature 1975;254(5497):269-70.
1975: Doherty P C; Zinkernagel R M
Quantitative studies of the growth and rejection of allogeneic tumour cells in mouse cerebrospinal fluid. Elimination in the absence of H-2 differences.
Clinical and experimental immunology 1975;19(2):355-66.
1975: Doherty P C; Zinkernagel R M
H-2 compatibility is required for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus.
The Journal of experimental medicine 1975;141(2):502-7.
1975: Demierre G; River D; Hilpert H; Gerber H; Zinkernagel R
[Adherence of pathogenic Escherichia coli to epithelial cells isolated from the intestinal mucosa of the rabbit, inhibiting effect of hyperimmune bovine colostrum and of various carbohydrates (author's transl)]
Pathologia et microbiologia 1975;42(3):137-46.
1974: Zinkernagel R M; Doherty P C
Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytic choriomeningitis.
Nature 1974;251(5475):547-8.
1974: Zinkernagel R M
Restriction by H-2 gene complex of transfer of cell-mediated immunity to Listeria monocytogenes.
Nature 1974;251(5472):230-3.
1974: Doherty P C; Zinkernagel R M; Ramshaw I A
Specificity and development of cytotoxic thymus-derived lymphocytes in lymphocytic choriomeningitis.
Journal of immunology (Baltimore, Md. : 1950) 1974;112(4):1548-52.
1974: Zinkernagel R M; Doherty P C
Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system.
Nature 1974;248(450):701-2.
1974: Zinkernagel R M; Blanden R V; Langman R E
Early appearance of sensitized lymphocytes in mice infected with Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950) 1974;112(2):496-501.
1974: Doherty P C; Zinkernagel R M
T-cell-mediated immunopathology in viral infections.
Transplantation reviews 1974;19(0):89-120.
1974: Zinkernagel R M; Doherty P C
Characteristics of the interaction in vitro between cytotoxic thymus-derived lymphocytes and target monolayers infected with lymphocytic choriomeningitis virus.
Scandinavian journal of immunology 1974;3(3):287-94.
1973: Zinkernagel R M; Doherty P C
Cytotoxic thymus-derived lymphocytes in cerebrospinal fluid of mice with lymphocytic choriomeningitis.
The Journal of experimental medicine 1973;138(5):1266-9.
1973: Frei P C; Erard P; Zinkernagel R
Cell-mediated immunity to hepatitis-associated antigen (HAA) demonstrated by leucocyte migration test during and after acute B hepatitis.
Biomedicine / [publiée pour l'A.A.I.C.I.G.] 1973;19(9):379-83.
1972: Zinkernagel R; Riede U N; Schenk R K
[Ultrastructural studies of the juxtaepiphyseal capillaries after perfusion fixation]
Experientia 1972;28(10):1205-6.
1972: Riede U N; Zinkernagel R; Rohr H P
[Gold phagocytosis by the chondrocytes of articular cartilage and menisci]
Schweizerische medizinische Wochenschrift 1972;102(17):614-7.
1971: Riede U N; Zinkernagel R; Remagen W; Villiger W
[Cartilage mineralization following circumscript lesion of the tibial epiphyseal plate in rats (contribution to the clarification of the role of lysosomes in chondrocytes)]
Beiträge zur Pathologie 1971;143(3):271-82.
1970: Zinkernagel R
[Distal types of plexus brachialis neuritis]
Schweizerische Rundschau für Medizin Praxis = Revue suisse de médecine Praxis 1970;59(46):1602-8.
1970: Schenk R K; Müller J; Zinkernagel R; Willenegger H
Ultrastructure of normal and abnormal bone repair.
Calcified tissue research 1970;():Suppl:110-1.

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