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Peter Zipfel

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Shanshan Luo; Christine Skerka; Ralf Hoffmann; Peter F Zipfel
Glycerol-3-phosphate dehydrogenase 2 is a novel factor H-, factor H-like protein 1-, and plasminogen-binding surface protein of Candida albicans.
Nina Simon; Christine Skerka; Sabrina Tews; Peter F Zipfel; Rainer Fischer; Andrea Kuehn; Edwin Lasonder; Matthias Scheuermayer; Gabriele Pradel
Malaria parasites co-opt human factor H to prevent complement-mediated lysis in the mosquito midgut.
Peter F Zipfel; Nadine Lauer
Defective complement action and control defines disease pathology for retinal and renal disorders and provides a basis for new therapeutic approaches.

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All Publications

2013: Shanshan Luo; Christine Skerka; Ralf Hoffmann; Peter F Zipfel
Glycerol-3-phosphate dehydrogenase 2 is a novel factor H-, factor H-like protein 1-, and plasminogen-binding surface protein of Candida albicans.
The Journal of infectious diseases 2013;207(4):594-603.
2013: Nina Simon; Christine Skerka; Sabrina Tews; Peter F Zipfel; Rainer Fischer; Andrea Kuehn; Edwin Lasonder; Matthias Scheuermayer; Gabriele Pradel
Malaria parasites co-opt human factor H to prevent complement-mediated lysis in the mosquito midgut.
Cell host & microbe 2013;13(1):29-41.
2013: Peter F Zipfel; Nadine Lauer
Defective complement action and control defines disease pathology for retinal and renal disorders and provides a basis for new therapeutic approaches.
Advances in experimental medicine and biology 2013;735():173-87.
2013: Peter F Zipfel; Nadine Lauer
Defective complement action and control defines disease pathology for retinal and renal disorders and provides a basis for new therapeutic approaches.
Advances in experimental medicine and biology 2013;734():173-87.
2012: Teresia Hallström; Ralf Hoffmann; Anja Kunert; Matthias Mörgelin; Marina Raguse; Christine Skerka; Diana Barthel; Peter F Zipfel
Dihydrolipoamide dehydrogenase of Pseudomonas aeruginosa is a surface-exposed immune evasion protein that binds three members of the factor H family and plasminogen.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(10):4939-50.
2012: Diana Barthel; Susann Schindler; Peter F Zipfel
Plasminogen is a complement inhibitor.
The Journal of biological chemistry 2012;287(22):18831-42.
2012: Peter F Zipfel; Christine Skerka
Complement, Candida, and cytokines: the role of C5a in host response to fungi.
European journal of immunology 2012;42(4):822-5.
2012: Tina K Koch; Peter Kraiczy; Michael Reuter; Diana Barthel; Sascha Böhm; Jean van den Elsen; Peter F Zipfel; Christine Skerka
Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b.
PloS one 2012;7(10):e47638.
2011: Peter F Zipfel; Gunter Wolf; Ulrike John; Karim Kentouche; Christine Skerka
Novel developments in thrombotic microangiopathies: is there a common link between hemolytic uremic syndrome and thrombotic thrombocytic purpura?
Pediatric nephrology (Berlin, Germany) 2011;26(11):1947-56.
2011: Nadine Lauer; Michael Mihlan; Ursula Schlötzer-Schrehardt; Hendrik P N Scholl; Christine Skerka; Bernhard H F Weber; Peter Charbel Issa; Andrea Hartmann; Frank Holz; Claudia N Keilhauer; Peter F Zipfel
Complement regulation at necrotic cell lesions is impaired by the age-related macular degeneration-associated factor-H His402 risk variant.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(8):4374-83.
2011: Josephine Losse; Eliška Svobodová; Peter F Zipfel; Antje Heyken; Bernhard Hube; Mihály Józsi
Role of pH-regulated antigen 1 of Candida albicans in the fungal recognition and antifungal response of human neutrophils.
Molecular immunology 2011;48(15-16):2135-43.
2011: Peter F Zipfel; Christine Skerka; Danny Kupka; Shanshan Luo
Immune escape of the human facultative pathogenic yeast Candida albicans: the many faces of the Candida Pra1 protein.
International journal of medical microbiology : IJMM 2011;301(5):423-30.
2011: Andreas Thywißen; Peter F Zipfel; Hans-Martin Dahse; Thorsten Heinekamp; Sandor Nietzsche; Jeannette Schmaler-Ripcke; Axel A Brakhage
Conidial Dihydroxynaphthalene Melanin of the Human Pathogenic Fungus Aspergillus fumigatus Interferes with the Host Endocytosis Pathway.
Frontiers in microbiology 2011;2():96.
2011: Anke Burmester; Marius Felder; Marc Feuermann; Gernot Glöckner; Marco Groth; Reinhard Guthke; Christoph Heddergott; Andrew Heidel; Joseph Heitman; Christian Hertweck; Bernhard Hube; Olaf Kniemeyer; Wenjun Li; Michel Monod; Ivo Pedruzzi; Andreas Petzold; Matthias Platzer; Steffen Priebe; Susann Schindler; Volker Schroeckh; Ekaterina Shelest; Peter Staib; Karol Szafranski; Theodore C White; Robert Winkler; Johannes Wöstemeyer; Peter F Zipfel; Axel A Brakhage
Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.
Genome biology 2011;12(1):R7.
2010: Michael Reuter; Clayton C Caswell; Slawomir Lukomski; Peter F Zipfel
Binding of the human complement regulators CFHR1 and factor H by streptococcal collagen-like protein 1 (Scl1) via their conserved C termini allows control of the complement cascade at multiple levels.
The Journal of biological chemistry 2010;285(49):38473-85.
2010: Lars G Fritsche; Nadine Lauer; Andrea Hartmann; Selina Stippa; Claudia N Keilhauer; Martin Oppermann; Manoj K Pandey; Jörg Köhl; Peter F Zipfel; Bernhard H F Weber; Christine Skerka
An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD).
Human molecular genetics 2010;19(23):4694-704.
2010: Peter F Zipfel; Christoph Mache; Dominik Müller; Christoph Licht; Marianne Wigger; Christine Skerka
DEAP-HUS: deficiency of CFHR plasma proteins and autoantibody-positive form of hemolytic uremic syndrome.
Pediatric nephrology (Berlin, Germany) 2010;25(10):2009-19.
2010: Christine Skerka; Peter F Zipfel; Dominik Müller; Sven Micklisch; Magdalena Riedl; Lothar B Zimmerhackl; Johannes Hofer
The autoimmune disease DEAP-hemolytic uremic syndrome.
Seminars in thrombosis and hemostasis 2010;36(6):625-32.
2010: Shanshan Luo; Andrea Hartmann; Hans-Martin Dahse; Christine Skerka; Peter F Zipfel
Secreted pH-regulated antigen 1 of Candida albicans blocks activation and conversion of complement C3.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(4):2164-73.
2010: Axel A Brakhage; Sandra Bruns; Andreas Thywissen; Peter F Zipfel; Judith Behnsen
Interaction of phagocytes with filamentous fungi.
Current opinion in microbiology 2010;13(4):409-15.
2010: Judith Behnsen; Franziska Lessing; Susann Schindler; Dirk Wartenberg; Ilse Jacobsen; Marcel Thoen; Peter F Zipfel; Axel A Brakhage
Secreted Aspergillus fumigatus protease Alp1 degrades human complement proteins C3, C4, and C5.
Infection and immunity 2010;78(8):3585-94.
2010: Josephine Losse; Peter F Zipfel; Mihály Józsi
Factor H and factor H-related protein 1 bind to human neutrophils via complement receptor 3, mediate attachment to Candida albicans, and enhance neutrophil antimicrobial activity.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(2):912-21.
2010: Peter F Zipfel; Nadine Lauer; Christine Skerka
The role of complement in AMD.
Advances in experimental medicine and biology 2010;703():9-24.
2010: Stefanie Strobel; Peter F Hoyer; Christoph J Mache; Endre Sulyok; Wei-Shih Liu; Heiko Richter; Martin Oppermann; Peter F Zipfel; Mihály Józsi
Functional analyses indicate a pathogenic role of factor H autoantibodies in atypical haemolytic uraemic syndrome.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2010;25(1):136-44.
2009: Katharina Gropp; Lydia Schild; Susann Schindler; Bernhard Hube; Peter F Zipfel; Christine Skerka
The yeast Candida albicans evades human complement attack by secretion of aspartic proteases.
Molecular immunology 2009;47(2-3):465-75.
2009: Shanshan Luo; Sophia Poltermann; Anja Kunert; Steffen Rupp; Peter F Zipfel
Immune evasion of the human pathogenic yeast Candida albicans: Pra1 is a Factor H, FHL-1 and plasminogen binding surface protein.
Molecular immunology 2009;47(2-3):541-50.
2009: M Mihlan; S Stippa; Mihály Józsi; Peter F Zipfel
Monomeric CRP contributes to complement control in fluid phase and on cellular surfaces and increases phagocytosis by recruiting factor H.
Cell death and differentiation 2009;16(12):1630-40.
2009: Peter F Zipfel; Christine Skerka
Complement regulators and inhibitory proteins.
Nature reviews. Immunology 2009;9(10):729-40.
2009: Peter F Zipfel
Complement and immune defense: from innate immunity to human diseases.
Immunology letters 2009;126(1-2):1-7.
2009: Stefan Heinen; Andrea Hartmann; Nadine Lauer; Ulrike Wiehl; Hans-Martin Dahse; Sylvia Schirmer; Katharina Gropp; Tina Enghardt; Reinhard Wallich; Steffi Hälbich; Michael Mihlan; Ursula Schlötzer-Schrehardt; Peter F Zipfel; Christine Skerka
Factor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation.
Blood 2009;114(12):2439-47.
2009: Christine Skerka; Christoph Licht; Michael Mengel; Barbara Uzonyi; Stefanie Strobel; Peter F Zipfel; Mihály Józsi
Autoimmune forms of thrombotic microangiopathy and membranoproliferative glomerulonephritis: Indications for a disease spectrum and common pathogenic principles.
Molecular immunology 2009;46(14):2801-7.
2009: Sandra Habbig; Michael J Mihatsch; Stefan Heinen; Bodo Beck; Mathias Emmel; Christine Skerka; Michael Kirschfink; Bernd Hoppe; Peter F Zipfel; Christoph Licht
C3 deposition glomerulopathy due to a functional factor H defect.
Kidney international 2009;75(11):1230-4.
2009: Christine Skerka; Mihály Józsi; Peter F Zipfel; Marie-Agnès Dragon-Durey; Veronique Fremeaux-Bacchi
Autoantibodies in haemolytic uraemic syndrome (HUS).
Thrombosis and haemostasis 2009;101(2):227-32.
2009: Peter F Zipfel; Richard J H Smith; Christine Skerka
Factor I and factor H deficiency in renal diseases: similar defects in the fluid phase have a different outcome at the surface of the glomerular basement membrane.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009;24(2):385-7.
2009: Michael Mihlan; Mario Hebecker; Hans-Martin Dahse; Steffi Hälbich; Markus Huber-Lang; Regine Dahse; Peter F Zipfel; Mihály Józsi
Human complement factor H-related protein 4 binds and recruits native pentameric C-reactive protein to necrotic cells.
Molecular immunology 2009;46(3):335-44.
2008: Peter F Zipfel; Teresia Hallström; Sven Hammerschmidt; Christine Skerka
The complement fitness factor H: role in human diseases and for immune escape of pathogens, like pneumococci.
Vaccine 2008;26 Suppl 8():I67-74.
2008: Christine Skerka; Peter F Zipfel
Complement factor H related proteins in immune diseases.
Vaccine 2008;26 Suppl 8():I9-14.
2008: Katrin Haupt; Michael Reuter; Jean van den Elsen; Julia Burman; Steffi Hälbich; Julia Richter; Christine Skerka; Peter F Zipfel
The Staphylococcus aureus protein Sbi acts as a complement inhibitor and forms a tripartite complex with host complement Factor H and C3b.
PLoS pathogens 2008;4(12):e1000250.
2008: Mihály Józsi; Peter F Zipfel
Factor H family proteins and human diseases.
Trends in immunology 2008;29(8):380-7.
2008: Michael Koziolek; Peter F Zipfel; Christine Skerka; Radovan Vasko; Elisabeth F Gröne; Gerhard A Müller; Frank Strutz
Chronic course of a hemolytic uremic syndrome caused by a deficiency of factor H-related proteins (CFHR1 and CFHR3).
Kidney international 2008;74(3):384-8.
2008: Ruben Martinez-Barricarte; Gaia Pianetti; Ruxandra Gautard; Joachim Misselwitz; Lisa Strain; Veronique Fremeaux-Bacchi; Christine Skerka; Peter F Zipfel; Timothy H J Goodship; Marina Noris; Giuseppe Remuzzi; Santiago Rodriguez de Cordoba
The complement factor H R1210C mutation is associated with atypical hemolytic uremic syndrome.
Journal of the American Society of Nephrology : JASN 2008;19(3):639-46.
2008: Georgia Vogl; I Lesiak; D B Jensen; Susanne Perkhofer; Raimund Eck; Cornelia Speth; Cornelia Lass-Flörl; Peter F Zipfel; A M Blom; Manfred P Dierich; Reinhard Wurzner
Immune evasion by acquisition of complement inhibitors: the mould Aspergillus binds both factor H and C4b binding protein.
Molecular immunology 2008;45(5):1485-93.
2008: Judith Behnsen; Andrea Hartmann; Jeannette Schmaler; Alexander Gehrke; Axel A Brakhage; Peter F Zipfel
The opportunistic human pathogenic fungus Aspergillus fumigatus evades the host complement system.
Infection and immunity 2008;76(2):820-7.
2008: Mihály Józsi; Christoph Licht; Stefanie Strobel; Svante L H Zipfel; Heiko Richter; Stefan Heinen; Peter F Zipfel; Christine Skerka
Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency.
Blood 2008;111(3):1512-4.
2007: Sophia Poltermann; Anja Kunert; Monika von der Heide; Raimund Eck; Andrea Hartmann; Peter F Zipfel
Gpm1p is a factor H-, FHL-1-, and plasminogen-binding surface protein of Candida albicans.
The Journal of biological chemistry 2007;282(52):37537-44.
2007: T. Sakari Jokiranta; Peter F Zipfel; Veronique Fremeaux-Bacchi; C Mark Taylor; Timothy J H Goodship; Marina Noris
Where next with atypical hemolytic uremic syndrome?
Molecular immunology 2007;44(16):3889-900.
2007: Peter F Zipfel; Reinhard Wurzner; Christine Skerka
Complement evasion of pathogens: common strategies are shared by diverse organisms.
Molecular immunology 2007;44(16):3850-7.
2007: Anja Kunert; Josephine Losse; Christin Gruszin; Michael Hühn; Kerstin Kaendler; Stefan Mikkat; Daniela Volke; Ralf Hoffmann; T. Sakari Jokiranta; Harald Seeberger; Ute Moellmann; Jens Hellwage; Peter F Zipfel
Immune evasion of the human pathogen Pseudomonas aeruginosa: elongation factor Tuf is a factor H and plasminogen binding protein.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(5):2979-88.
2007: Richard J H Smith; Jessy Alexander; Paul N Barlow; Marina Botto; Thomas L Cassavant; H Terence Cook; Santiago Rodriguez de Córdoba; Gregory S Hageman; T. Sakari Jokiranta; William J Kimberling; John D Lambris; Lynne D Lanning; Vicki Levidiotis; Christoph Licht; Hans U Lutz; Seppo Meri; Matthew C Pickering; Richard J Quigg; Angelique L W M M Rops; David J Salant; Sanjeev Sethi; Joshua M Thurman; Hope F Tully; Sean P Tully; Johan Van der Vlag; Patrick D Walker; Reinhard Wurzner; Peter F Zipfel
New approaches to the treatment of dense deposit disease.
Journal of the American Society of Nephrology : JASN 2007;18(9):2447-56.
2007: Mihály Józsi; Stefanie Strobel; Hans-Martin Dahse; Wei-shih Liu; Peter F Hoyer; Martin Oppermann; Christine Skerka; Peter F Zipfel
Anti factor H autoantibodies block C-terminal recognition function of factor H in hemolytic uremic syndrome.
Blood 2007;110(5):1516-8.
2007: Yvonne Wollmann; Uta Schmidt; Gerhard D. Wieland; Peter F Zipfel; Hans-Peter Saluz; Frank Hänel
The DNA topoisomerase IIbeta binding protein 1 (TopBP1) interacts with poly (ADP-ribose) polymerase (PARP-1).
Journal of cellular biochemistry 2007;102(1):171-82.
2007: Susann Jezewski; Monika von der Heide; Sophia Poltermann; Albert Härtl; Waldemar Künkel; Peter F Zipfel; Raimund Eck
Role of the Vps34p-interacting protein Ade5,7p in hyphal growth and virulence of Candida albicans.
Microbiology (Reading, England) 2007;153(Pt 7):2351-62.
2007: Katrin Haupt; Peter Kraiczy; Reinhard Wallich; Volker Brade; Christine Skerka; Peter F Zipfel
Binding of human factor H-related protein 1 to serum-resistant Borrelia burgdorferi is mediated by borrelial complement regulator-acquiring surface proteins.
The Journal of infectious diseases 2007;196(1):124-33.
2007: Christine Skerka; Nadine Lauer; Andreas A W A Weinberger; Claudia N Keilhauer; Jürgen Sühnel; Richard Smith; Ursula Schlötzer-Schrehardt; Lars G Fritsche; Stefan Heinen; Andrea Hartmann; Bernhard H F Weber; Peter F Zipfel
Defective complement control of factor H (Y402H) and FHL-1 in age-related macular degeneration.
Molecular immunology 2007;44(13):3398-406.
2007: Sven Hammerschmidt; Vaibhav Agarwal; Anja Kunert; Steffi Haelbich; Christine Skerka; Peter F Zipfel
The host immune regulator factor H interacts via two contact sites with the PspC protein of Streptococcus pneumoniae and mediates adhesion to host epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(9):5848-58.
2007: Mihály Józsi; Martin Oppermann; John D Lambris; Peter F Zipfel
The C-terminus of complement factor H is essential for host cell protection.
Molecular immunology 2007;44(10):2697-706.
2007: Mario Kraft; Dörte Radke; Gerhard D. Wieland; Peter F Zipfel; Uwe Horn
A fluorogenic substrate as quantitative in vivo reporter to determine protein expression and folding of tobacco etch virus protease in Escherichia coli.
Protein expression and purification 2007;52(2):478-84.
2007: Peter F Zipfel; Matthew Edey; Stefan Heinen; Mihály Józsi; Heiko Richter; Joachim Misselwitz; Bernd Hoppe; Danny Routledge; Lisa Strain; Anne E Hughes; Judith A Goodship; Christoph Licht; Timothy H J Goodship; Christine Skerka
Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome.
PLoS genetics 2007;3(3):e41.
2007: Rebecca E Saunders; Cynthia Abarrategui-Garrido; Véronique Frémeaux-Bacchi; Elena Goicoechea de Jorge; Timothy H J Goodship; Margarita López-Trascasa; Marina Noris; Isabel Maria Ponce Castro; Giuseppe Remuzzi; Santiago Rodríguez de Córdoba; Pilar Sánchez-Corral; Christine Skerka; Peter F Zipfel; Stephen J Perkins
The interactive Factor H-atypical hemolytic uremic syndrome mutation database and website: update and integration of membrane cofactor protein and Factor I mutations with structural models.
Human mutation 2007;28(3):222-34.
2007: Stefan Heinen; Mihály Józsi; Andrea Hartmann; Marina Noris; Giuseppe Remuzzi; Christine Skerka; Peter F Zipfel
Hemolytic uremic syndrome: a factor H mutation (E1172Stop) causes defective complement control at the surface of endothelial cells.
Journal of the American Society of Nephrology : JASN 2007;18(2):506-14.
2007: Peter F Zipfel; Michael Mihlan; Christine Skerka
The alternative pathway of complement: a pattern recognition system.
Advances in experimental medicine and biology 2007;598():80-92.
2007: Christoph Licht; Ursula Schlötzer-Schrehardt; Michael Kirschfink; Peter F Zipfel; Bernd Hoppe
MPGN II--genetically determined by defective complement regulation?
Pediatric nephrology (Berlin, Germany) 2007;22(1):2-9.
2006: Jens Hellwage; Florian Eberle; Tanja Babuke; Harald Seeberger; Heiko Richter; Anja Kunert; Albert Härtl; Peter F Zipfel; T. Sakari Jokiranta; Mihály Józsi
Two factor H-related proteins from the mouse: expression analysis and functional characterization.
Immunogenetics 2006;58(11):883-93.
2006: Kathrin Franke; Monika Nguyen; Albert Härtl; Hans-Martin Dahse; Georgia Vogl; Reinhard Wurzner; Peter F Zipfel; Waldemar Künkel; Raimund Eck
The vesicle transport protein Vac1p is required for virulence of Candida albicans.
Microbiology (Reading, England) 2006;152(Pt 10):3111-21.
2006: Peter F Zipfel; Christine Skerka
Complement dysfunction in hemolytic uremic syndrome.
Current opinion in rheumatology 2006;18(5):548-55.
2006: Christoph Licht; Stefan Heinen; Mihály Józsi; I Löschmann; Rebecca E Saunders; Stephen J Perkins; R Waldherr; Christine Skerka; Michael Kirschfink; Bernd Hoppe; Peter F Zipfel
Deletion of Lys224 in regulatory domain 4 of Factor H reveals a novel pathomechanism for dense deposit disease (MPGN II).
Kidney international 2006;70(1):42-50.
2006: M A Abrera-Abeleda; Carla Nishimura; J L H Smith; Sanjeev Sethi; Jennifer L McRae; Brendan F Murphy; G Silvestri; Christine Skerka; Mihály Józsi; Peter F Zipfel; Gregory S Hageman; R J H Smith
Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease).
Journal of medical genetics 2006;43(7):582-9.
2006: Martin Oppermann; Tamara Manuelian; Mihály Józsi; E Brandt; T. Sakari Jokiranta; Stefan Heinen; Seppo Meri; Christine Skerka; Otto Götze; Peter F Zipfel
The C-terminus of complement regulator Factor H mediates target recognition: evidence for a compact conformation of the native protein.
Clinical and experimental immunology 2006;144(2):342-52.
2006: Peter F Zipfel; Joachim Misselwitz; Christoph Licht; Christine Skerka
The role of defective complement control in hemolytic uremic syndrome.
Seminars in thrombosis and hemostasis 2006;32(2):146-54.
2006: Stefan Heinen; Pilar Sanchez-Corral; Michael S Jackson; Lisa Strain; Judith A Goodship; Elizabeth J Kemp; Christine Skerka; T. Sakari Jokiranta; Kevin Meyers; Eric Wagner; Pierre Robitaille; Jorge Esparza-Gordillo; Santiago Rodriguez de Cordoba; Peter F Zipfel; Timothy H J Goodship
De novo gene conversion in the RCA gene cluster (1q32) causes mutations in complement factor H associated with atypical hemolytic uremic syndrome.
Human mutation 2006;27(3):292-3.
2006: Zhu-Zhu Cheng; Jens Hellwage; Harald Seeberger; Peter F Zipfel; Seppo Meri; T. Sakari Jokiranta
Comparison of surface recognition and C3b binding properties of mouse and human complement factor H.
Molecular immunology 2006;43(7):972-9.
2006: Mihály Józsi; Stefan Heinen; Andrea Hartmann; Clemens W Ostrowicz; Steffi Hälbich; Heiko Richter; Anja Kunert; Christoph Licht; Rebecca E Saunders; Stephen J Perkins; Peter F Zipfel; Christine Skerka
Factor H and atypical hemolytic uremic syndrome: mutations in the C-terminus cause structural changes and defective recognition functions.
Journal of the American Society of Nephrology : JASN 2006;17(1):170-7.
2006: Rebecca E Saunders; Timothy H J Goodship; Peter F Zipfel; Stephen J Perkins
An interactive web database of factor H-associated hemolytic uremic syndrome mutations: insights into the structural consequences of disease-associated mutations.
Human mutation 2006;27(1):21-30.
2006: Peter F Zipfel; Stefan Heinen; Mihály Józsi; Christine Skerka
Complement and diseases: defective alternative pathway control results in kidney and eye diseases.
Molecular immunology 2006;43(1-2):97-106.
2005: T. Sakari Jokiranta; Zhu-Zhu Cheng; Harald Seeberger; Mihály Jòzsi; Stefan Heinen; Marina Noris; Giuseppe Remuzzi; Rebecca J Ormsby; David L Gordon; Seppo Meri; Jens Hellwage; Peter F Zipfel
Binding of complement factor H to endothelial cells is mediated by the carboxy-terminal glycosaminoglycan binding site.
The American journal of pathology 2005;167(4):1173-81.
2005: Gerhard D. Wieland; Nina Nehmann; Doreen Müller; Hermann Eibel; Ulrich Siebenlist; Jürgen Sühnel; Peter F Zipfel; Christine Skerka
Early growth response proteins EGR-4 and EGR-3 interact with immune inflammatory mediators NF-kappaB p50 and p65.
Journal of cell science 2005;118(Pt 14):3203-12.
2005: Sophia Poltermann; Monika Nguyen; Juliane Günther; Jürgen Wendland; Albert Härtl; Waldemar Künkel; Peter F Zipfel; Raimund Eck
The putative vacuolar ATPase subunit Vma7p of Candida albicans is involved in vacuole acidification, hyphal development and virulence.
Microbiology (Reading, England) 2005;151(Pt 5):1645-55.
2005: Gerald B Appel; H Terence Cook; Gregory S Hageman; John Jennette; Michael Kashgarian; Michael Kirschfink; John D Lambris; Lynne D Lanning; Hans U Lutz; Seppo Meri; Noel R Rose; David J Salant; Sanjeev Sethi; Richard J H Smith; William E Smoyer; Hope F Tully; Sean P Tully; Patrick Walker; Michael Welsh; Reinhard Wurzner; Peter F Zipfel
Membranoproliferative glomerulonephritis type II (dense deposit disease): an update.
Journal of the American Society of Nephrology : JASN 2005;16(5):1392-403.
2005: Zhu-Zhu Cheng; Michael J Corey; Maria Pärepalo; Sandra Majno; Jens Hellwage; Peter F Zipfel; Robert Kinders; Mika Raitanen; Seppo Meri; T. Sakari Jokiranta
Complement factor H as a marker for detection of bladder cancer.
Clinical chemistry 2005;51(5):856-63.
2005: Raimund Eck; Monika Nguyen; Juliane Günther; Waldemar Künkel; Peter F Zipfel
The phosphatidylinositol 3-kinase Vps34p of the human pathogenic yeast Candida albicans is a multifunctional protein that interacts with the putative vacuolar H+ -ATPase subunit Vma7p.
International journal of medical microbiology : IJMM 2005;295(1):57-66.
2005: Mihály Józsi; Heiko Richter; Ina Löschmann; Christine Skerka; Friedrich Buck; Ulrike Beisiegel; Anna Erdei; Peter F Zipfel
FHR-4A: a new factor H-related protein is encoded by the human FHR-4 gene.
European journal of human genetics : EJHG 2005;13(3):321-9.
2005: Christoph Licht; Annic Weyersberg; Stefan Heinen; Ludwig Stapenhorst; Jacqueline Devenge; Bodo Beck; Ruediger Waldherr; Michael Kirschfink; Peter F Zipfel; Bernd Hoppe
Successful plasma therapy for atypical hemolytic uremic syndrome caused by factor H deficiency owing to a novel mutation in the complement cofactor protein domain 15.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2005;45(2):415-21.
2005: Juliane Günther; Monika Nguyen; Albert Härtl; Waldemar Künkel; Peter F Zipfel; Raimund Eck
Generation and functional in vivo characterization of a lipid kinase defective phosphatidylinositol 3-kinase Vps34p of Candida albicans.
Microbiology (Reading, England) 2005;151(Pt 1):81-9.
2004: Taru Meri; Anna Blom; Andrea Hartmann; D Lenk; Seppo Meri; Peter F Zipfel
The hyphal and yeast forms of Candida albicans bind the complement regulator C4b-binding protein.
Infection and immunity 2004;72(11):6633-41.
2004: Hanna Jarva; Jens Hellwage; T. Sakari Jokiranta; Markus J Lehtinen; Peter F Zipfel; Seppo Meri
The group B streptococcal beta and pneumococcal Hic proteins are structurally related immune evasion molecules that bind the complement inhibitor factor H in an analogous fashion.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(5):3111-8.
2004: Mihály Józsi; Tamara Manuelian; Stefan Heinen; Martin Oppermann; Peter F Zipfel
Attachment of the soluble complement regulator factor H to cell and tissue surfaces: relevance for pathology.
Histology and histopathology 2004;19(1):251-8.
2003: Nele Braun; Yeboah Marfo; Christiane Von Gärtner; Gerd D Burchard; Peter F Zipfel; N Edmund N Browne; Bernhard Fleischer; Barbara M Bröker
CTLA-4 positive T cells in contrast to procalcitonin plasma levels discriminate between severe and uncomplicated Plasmodium falciparum malaria in Ghanaian children.
Tropical medicine & international health : TM & IH 2003;8(11):1018-24.
2003: Peter F Zipfel; Hartmut P H Neumann; Mihály Józsi
Genetic screening in haemolytic uraemic syndrome.
Current opinion in nephrology and hypertension 2003;12(6):653-7.
2003: Guido A Hegasy; Ute Willhoeft; Sandra A Majno; Harald Seeberger; Peter F Zipfel; Jens Hellwage
Pig complement regulator factor H: molecular cloning and functional characterization.
Immunogenetics 2003;55(7):462-71.
2003: Manuel A Friese; Tamara Manuelian; Sami Junnikkala; Jens Hellwage; Seppo Meri; HH Peter; David L Gordon; Hermann Eibel; Peter F Zipfel
Release of endogenous anti-inflammatory complement regulators FHL-1 and factor H protects synovial fibroblasts during rheumatoid arthritis.
Clinical and experimental immunology 2003;132(3):485-95.
2003: Peter Fischer; Sylvain Djoha; Dietrich W Büttner; Peter F Zipfel
Isolation and characterization of the regulatory subunit of cAMP-dependent protein kinase from the filarial parasite Onchocerca volvulus.
Molecular and biochemical parasitology 2003;128(1):33-42.
2003: Tamara Manuelian; Jens Hellwage; Seppo Meri; Jessica Caprioli; Marina Noris; Stefan Heinen; Mihaly Jozsi; Hartmut P H Neumann; Giuseppe Remuzzi; Peter F Zipfel
Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome.
The Journal of clinical investigation 2003;111(8):1181-90.
2003: Eva L Decker; Nina Nehmann; Eva Kampen; Hermann Eibel; Peter F Zipfel; Christine Skerka
Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression.
Nucleic acids research 2003;31(3):911-21.
2002: Jens Hellwage; T. Sakari Jokiranta; Manuel A Friese; Tobias U Wolk; Eva Kampen; Peter F Zipfel; Seppo Meri
Complement C3b/C3d and cell surface polyanions are recognized by overlapping binding sites on the most carboxyl-terminal domain of complement factor H.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(12):6935-44.
2002: Guido A Hegasy; Tamara Manuelian; Kolbjorn Hogasen; Johan H Jansen; Peter F Zipfel
The molecular basis for hereditary porcine membranoproliferative glomerulonephritis type II: point mutations in the factor H coding sequence block protein secretion.
The American journal of pathology 2002;161(6):2027-34.
2002: Sami Junnikkala; Juha Hakulinen; Hanna Jarva; Tamara Manuelian; Line Bjørge; Ralf Bützow; Peter F Zipfel; Seppo Meri
Secretion of soluble complement inhibitors factor H and factor H-like protein (FHL-1) by ovarian tumour cells.
British journal of cancer 2002;87(10):1119-27.
2002: Peter F Zipfel; Christine Skerka; Jens Hellwage; T. Sakari Jokiranta; Seppo Meri; Volker Brade; Peter Kraiczy; Marina Noris; Giuseppe Remuzzi
Factor H family proteins: on complement, microbes and human diseases.
Biochemical Society transactions 2002;30(Pt 6):971-8.
2002: Taru Meri; Andrea Hartmann; D Lenk; Raimund Eck; Reinhard Wurzner; Jens Hellwage; Seppo Meri; Peter F Zipfel
The yeast Candida albicans binds complement regulators factor H and FHL-1.
Infection and immunity 2002;70(9):5185-92.
2002: Taru Meri; T. Sakari Jokiranta; Jens Hellwage; Alexandra Bialonski; Peter F Zipfel; Seppo Meri
Onchocerca volvulus microfilariae avoid complement attack by direct binding of factor H.
The Journal of infectious diseases 2002;185(12):1786-93.
2002: Hanna Jarva; Robert Janulczyk; Jens Hellwage; Peter F Zipfel; Lars Björck; Seppo Meri
Streptococcus pneumoniae evades complement attack and opsonophagocytosis by expressing the pspC locus-encoded Hic protein that binds to short consensus repeats 8-11 of factor H.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(4):1886-94.
2001: Peter F Zipfel
Hemolytic uremic syndrome: how do factor H mutants mediate endothelial damage?
Trends in immunology 2001;22(7):345-8.
2001: Peter F Zipfel
Complement factor H: physiology and pathophysiology.
Seminars in thrombosis and hemostasis 2001;27(3):191-9.
2001: Mihály Józsi; A Kapus; Krisztina Kerekes; J Kármán; Zsuzsa Bajtay; Peter F Zipfel; Anna Erdei
Characterization of factor H-related cell membrane molecules expressed by human B lymphocytes and neutrophil granulocytes.
Immunology letters 2001;77(1):55-62.
2001: Peter F Zipfel; Christine Skerka; J Caprioli; Tamara Manuelian; H H Neumann; Marina Noris; Giuseppe Remuzzi
Complement factor H and hemolytic uremic syndrome.
International immunopharmacology 2001;1(3):461-8.
2000: T. Sakari Jokiranta; Jens Hellwage; Vesa Koistinen; Peter F Zipfel; Seppo Meri
Each of the three binding sites on complement factor H interacts with a distinct site on C3b.
The Journal of biological chemistry 2000;275(36):27657-62.
2000: Manuel A Friese; Jens Hellwage; T. Sakari Jokiranta; Seppo Meri; H J Müller-Quernheim; HH Peter; Hermann Eibel; Peter F Zipfel
Different regulation of factor H and FHL-1/reconectin by inflammatory mediators and expression of the two proteins in rheumatoid arthritis (RA).
Clinical and experimental immunology 2000;121(2):406-15.
2000: Sami Junnikkala; T. Sakari Jokiranta; Manuel A Friese; Hanna Jarva; Peter F Zipfel; Seppo Meri
Exceptional resistance of human H2 glioblastoma cells to complement-mediated killing by expression and utilization of factor H and factor H-like protein 1.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(11):6075-81.
2000: C Kemper; I Gigli; Peter F Zipfel
Conservation of plasma regulatory proteins of the complement system in evolution: humans and fish.
Experimental and clinical immunogenetics 2000;17(2):55-62.
1999: Jens Hellwage; T. Sakari Jokiranta; Vesa Koistinen; O Vaarala; Seppo Meri; Peter F Zipfel
Functional properties of complement factor H-related proteins FHR-3 and FHR-4: binding to the C3d region of C3b and differential regulation by heparin.
FEBS letters 1999;462(3):345-52.
1999: T. Sakari Jokiranta; Alan Solomon; M K Pangburn; Peter F Zipfel; Seppo Meri
Nephritogenic lambda light chain dimer: a unique human miniautoantibody against complement factor H.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(8):4590-6.
1999: Hanna Jarva; T. Sakari Jokiranta; Jens Hellwage; Peter F Zipfel; Seppo Meri
Regulation of complement activation by C-reactive protein: targeting the complement inhibitory activity of factor H by an interaction with short consensus repeat domains 7 and 8-11.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(7):3957-62.
1999: Manuel A Friese; Jens Hellwage; T. Sakari Jokiranta; Seppo Meri; HH Peter; Hermann Eibel; Peter F Zipfel
FHL-1/reconectin and factor H: two human complement regulators which are encoded by the same gene are differently expressed and regulated.
Molecular immunology 1999;36(13-14):809-18.
1999: Peter F Zipfel; T. Sakari Jokiranta; Jens Hellwage; Vesa Koistinen; Seppo Meri
The factor H protein family.
Immunopharmacology 1999;42(1-3):53-60.
1999: Peter F Zipfel; Jens Hellwage; Manuel A Friese; Guido A Hegasy; T. Sakari Jokiranta; Seppo Meri
Factor H and disease: a complement regulator affects vital body functions.
Molecular immunology 1999;36(4-5):241-8.
1999: Peter F Zipfel; Christine Skerka
FHL-1/reconectin: a human complement and immune regulator with cell-adhesive function.
Immunology today 1999;20(3):135-40.
1998: Eva L Decker; Christine Skerka; Peter F Zipfel
The early growth response protein (EGR-1) regulates interleukin-2 transcription by synergistic interaction with the nuclear factor of activated T cells.
The Journal of biological chemistry 1998;273(41):26923-30.
1998: Peter F Zipfel; S Schrum; A Bialonski; Dietrich W Büttner
The peroxidoxin 2 protein of the human parasite Onchocerca volvulus: recombinant expression, immunolocalization, and demonstration of homologous molecules in other species.
Parasitology research 1998;84(8):623-31.
1998: C Kemper; Peter F Zipfel; I Gigli
The complement cofactor protein (SBP1) from the barred sand bass (Paralabrax nebulifer) mediates overlapping regulatory activities of both human C4b binding protein and factor H.
The Journal of biological chemistry 1998;273(31):19398-404.
1998: S Schrum; A Bialonski; Thomas Marti; Peter F Zipfel
Identification of a peroxidoxin protein (OvPXN-2) of the human parasitic nematode Onchocerca volvulus by sequential protein fractionation.
Molecular and biochemical parasitology 1998;94(1):131-5.
1998: Timothy Blackmore; Jens Hellwage; Tania Sadlon; N Higgs; Peter F Zipfel; HM Ward; David L Gordon
Identification of the second heparin-binding domain in human complement factor H.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(7):3342-8.
1997: Jens Hellwage; Christine Skerka; Peter F Zipfel
Biochemical and functional characterization of the factor-H-related protein 4 (FHR-4).
Immunopharmacology 1997;38(1-2):149-57.
1997: Christine Skerka; Eva L Decker; Peter F Zipfel
Coordinate expression and distinct DNA-binding characteristics of the four EGR-zinc finger proteins in Jurkat T lymphocytes.
Immunobiology 1997;198(1-3):179-91.
1997: Peter F Zipfel; Eva L Decker; C Holst; Christine Skerka
The human zinc finger protein EGR-4 acts as autoregulatory transcriptional repressor.
Biochimica et biophysica acta 1997;1354(2):134-44.
1997: Jens Hellwage; S Kühn; Peter F Zipfel
The human complement regulatory factor-H-like protein 1, which represents a truncated form of factor H, displays cell-attachment activity.
The Biochemical journal 1997;326 ( Pt 2)():321-7.
1997: Kimberly Henkle-Dührsen; R S Tuan; G Wildenburg; Marie-Luise Eschbach; WN Tawe; Peter F Zipfel; Rolf D Walter
Localization and functional analysis of the cytosolic and extracellular CuZn superoxide dismutases in the human parasitic nematode Onchocerca volvulus.
Molecular and biochemical parasitology 1997;88(1-2):187-202.
1997: Norbert W Brattig; Kimberly Henkle-Dührsen; S Hounkpatin; Eva Liebau; Thomas F Kruppa; Peter F Zipfel
Characterization of human immune responses to the cytosolic superoxide dismutase and glutathione S-transferase from Onchocerca volvulus.
Tropical medicine & international health : TM & IH 1997;2(8):788-98.
1997: Christine Skerka; Jens Hellwage; W Weber; A Tilkorn; F Buck; Thomas Marti; Eva Kampen; U Beisiegel; Peter F Zipfel
The human factor H-related protein 4 (FHR-4). A novel short consensus repeat-containing protein is associated with human triglyceride-rich lipoproteins.
The Journal of biological chemistry 1997;272(9):5627-34.
1996: Peter F Zipfel; C Kemper; A Dahmen; I Gigli
Cloning and recombinant expression of a barred sand bass (Paralabrax nebulifer) cDNA. The encoded protein displays structural homology and immunological crossreactivity to human complement/cofactor related plasma proteins.
Developmental and comparative immunology 1996;20(6):407-16.
1996: S Schrum; Peter Probst; Bernhard Fleischer; Peter F Zipfel
Synthesis of the CC-chemokines MIP-1alpha, MIP-1beta, and RANTES is associated with a type 1 immune response.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(8):3598-604.
1996: S Kühn; Peter F Zipfel
Mapping of the domains required for decay acceleration activity of the human factor H-like protein 1 and factor H.
European journal of immunology 1996;26(10):2383-7.
1996: T. Sakari Jokiranta; Peter F Zipfel; Juha Hakulinen; S Kühn; M K Pangburn; J D Tamerius; Seppo Meri
Analysis of the recognition mechanism of the alternative pathway of complement by monoclonal anti-factor H antibodies: evidence for multiple interactions between H and surface bound C3b.
FEBS letters 1996;393(2-3):297-302.
1996: C Holst; Peter F Zipfel
A zinc finger gene from Onchocerca volvulus encodes a protein with a functional signal peptide and an unusual Ser-His finger motif.
The Journal of biological chemistry 1996;271(28):16725-33.
1995: S Kühn; Christine Skerka; Peter F Zipfel
Mapping of the complement regulatory domains in the human factor H-like protein 1 and in factor H1.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(12):5663-70.
1995: Christine Skerka; Eva L Decker; Peter F Zipfel
A regulatory element in the human interleukin 2 gene promoter is a binding site for the zinc finger proteins Sp1 and EGR-1.
The Journal of biological chemistry 1995;270(38):22500-6.
1995: S Kühn; Peter F Zipfel
The baculovirus expression vector pBSV-8His directs secretion of histidine-tagged proteins.
Gene 1995;162(2):225-9.
1995: Christian G Meyer; Christine Skerka; Peter F Zipfel
Polymorphism of the human factor H-related gene (FHR-1) and of factor H in a west African individual.
Immunogenetics 1995;41(5):335.
1995: Christine Skerka; J M Moulds; P Taillon-Miller; Dennis E Hourcade; Peter F Zipfel
The human factor H-related gene 2 (FHR2): structure and linkage to the coagulation factor XIIIb gene.
Immunogenetics 1995;42(4):268-74.
1994: A Dahmen; T Kaidoh; Peter F Zipfel; I Gigli
Cloning and characterization of a cDNA representing a putative complement-regulatory plasma protein from barred sand bass (Parablax neblifer).
The Biochemical journal 1994;301 ( Pt 2)():391-7.
1994: Peter F Zipfel; Christine Skerka
Complement factor H and related proteins: an expanding family of complement-regulatory proteins?
Immunology today 1994;15(3):121-6.
1993: C Holst; Peter F Zipfel
Identification of a zinc finger encoding gene in Onchocerca volvulus.
Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft für Technische Zusammenarbeit (GTZ) 1993;44(3):147-51.
1993: Christine Skerka; Peter F Zipfel; U Siebenlist
Two regulatory domains are required for downregulation of c-myc transcription in differentiating U937 cells.
Oncogene 1993;8(8):2135-43.
1993: C Holst; Christine Skerka; P Lichter; A Bialonski; Peter F Zipfel
Genomic organization, chromosomal localization and promoter function of the human zinc-finger gene pAT133.
Human molecular genetics 1993;2(4):367-72.
1993: Christine Skerka; S G Irving; A Bialonski; Peter F Zipfel
Cell type specific expression of members of the IL-8/NAP-1 gene family.
Cytokine 1993;5(2):112-6.
1993: Christine Skerka; S Kühn; K Günther; Klaus Lingelbach; Peter F Zipfel
A novel short consensus repeat-containing molecule is related to human complement factor H.
The Journal of biological chemistry 1993;268(4):2904-8.
1992: Peter F Zipfel; K A Wharton; J Villalobos; S G Irving; K Kelly; U Siebenlist
Employment of antipeptide antisera to distinguish two closely related cytokines induced in human T cells.
Lymphokine and cytokine research 1992;11(3):141-8.
1992: Christine Skerka; C Timmann; Rolf D Horstmann; Peter F Zipfel
Two additional human serum proteins structurally related to complement factor H. Evidence for a family of factor H-related genes.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(10):3313-8.
1991: Peter F Zipfel; A Bialonski; Christine Skerka
Induction of members of the IL-8/NAP-1 gene family in human T lymphocytes is suppressed by cyclosporin A.
Biochemical and biophysical research communications 1991;181(1):179-83.
1991: H J Müller; Christine Skerka; A Bialonski; Peter F Zipfel
Clone pAT 133 identifies a gene that encodes another human member of a class of growth factor-induced genes with almost identical zinc-finger domains.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(22):10079-83.
1991: Christine Skerka; Rolf D Horstmann; Peter F Zipfel
Molecular cloning of a human serum protein structurally related to complement factor H.
The Journal of biological chemistry 1991;266(18):12015-20.
1990: S G Irving; Peter F Zipfel; J Balke; O W McBride; C C Morton; PR Burd; Ulrich Siebenlist; K Kelly
Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q.
Nucleic acids research 1990;18(11):3261-70.
1989: K C Gunter; S G Irving; Peter F Zipfel; Ulrich Siebenlist; K Kelly
Cyclosporin A-mediated inhibition of mitogen-induced gene transcription is specific for the mitogenic stimulus and cell type.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(9):3286-91.
1989: S G Irving; Carl H June; Peter F Zipfel; Ulrich Siebenlist; K Kelly
Mitogen-induced genes are subject to multiple pathways of regulation in the initial stages of T-cell activation.
Molecular and cellular biology 1989;9(3):1034-40.
1989: Peter F Zipfel; J Balke; S G Irving; K Kelly; Ulrich Siebenlist
Mitogenic activation of human T cells induces two closely related genes which share structural similarities with a new family of secreted factors.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(5):1582-90.
1989: Peter F Zipfel; S G Irving; K Kelly; Ulrich Siebenlist
Complexity of the primary genetic response to mitogenic activation of human T cells.
Molecular and cellular biology 1989;9(3):1041-8.