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Antonio Zorzano

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Chemicals & Drugs

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Cystinuria

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Francisco Ortega; Neus Pueyo; Wifredo Ricart; Bartomeu Ruiz; Mónica Sabater; Sergio Valdés; Antonio Zorzano; Matteo Serino; Fatima Bosch; Patricia Botas; Remy Burcelin; Elias Delgado; Gema Frühbeck; Elodie Luche; Josep M Mercader; Gertrude Mingrone; José M Moreno-Navarrete; Deborah Naon; José M Fernández-Real
Targeting the association of calgranulin B (S100A9) with insulin resistance and type 2 diabetes.
Roberto Bravo; Damián Gatica; Joseph A Hill; Enrique Jaimovich; Felipe Paredes; Valentina Parra; Andrew F G Quest; Andrea E Rodriguez; Natalia Torrealba; Zhao V Wang; Antonio Zorzano; Sergio Lavandero
Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration.
Meritxell Costa; Dimitrios Fotiadis; Albert Rosell; Antonio Zorzano; Elena Álvarez-Marimon; Manuel Palacín
Expression of human heteromeric amino acid transporters in the yeast Pichia pastoris.

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All Publications

2013: Francisco Ortega; Neus Pueyo; Wifredo Ricart; Bartomeu Ruiz; Mónica Sabater; Sergio Valdés; Antonio Zorzano; Matteo Serino; Fatima Bosch; Patricia Botas; Remy Burcelin; Elias Delgado; Gema Frühbeck; Elodie Luche; Josep M Mercader; Gertrude Mingrone; José M Moreno-Navarrete; Deborah Naon; José M Fernández-Real
Targeting the association of calgranulin B (S100A9) with insulin resistance and type 2 diabetes.
Journal of molecular medicine (Berlin, Germany) 2013;91(4):523-34.
2013: Roberto Bravo; Damián Gatica; Joseph A Hill; Enrique Jaimovich; Felipe Paredes; Valentina Parra; Andrew F G Quest; Andrea E Rodriguez; Natalia Torrealba; Zhao V Wang; Antonio Zorzano; Sergio Lavandero
Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration.
International review of cell and molecular biology 2013;301():215-90.
2013: Meritxell Costa; Dimitrios Fotiadis; Albert Rosell; Antonio Zorzano; Elena Álvarez-Marimon; Manuel Palacín
Expression of human heteromeric amino acid transporters in the yeast Pichia pastoris.
Protein expression and purification 2013;87(1):35-40.
2013: José María Moreno-Navarrete; Francisco Ortega; Wifredo Ricart; Mònica Sabater; Miguel Ángel Sánchez-Garrido; Manuel Tena-Sempere; Antonio Zorzano; José Manuel Fernández-Real
Phosphorylated S6K1 (Thr389) is a molecular adipose tissue marker of altered glucose tolerance.
The Journal of nutritional biochemistry 2013;24(1):32-8.
2012: Chenjing Yang; Antonio Zorzano; Cho Cho Aye; Angels Diaz Ramos; Xiaoxin Li; Silvia Mora
Mitochondrial dysfunction in insulin resistance: differential contributions of chronic insulin and saturated fatty acid exposure in muscle cells.
Bioscience reports 2012;32(5):465-78.
2012: Caroline Mauvezin; Manuel Palacin; Ana Sancho; Saska Ivanova; Antonio Zorzano
DOR undergoes nucleo-cytoplasmic shuttling, which involves passage through the nucleolus.
FEBS letters 2012;586(19):3179-86.
2012: Pedro M Quirós; Andrew J Ramsay; Francisco Rodríguez; David Sala; José A Vega; Antonio Zorzano; José Antonio Enríquez; Maria Soledad Fernández-García; Erika Fernández-Vizarra; Juan R Peinado; Carlos López-Otín
Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice.
The EMBO journal 2012;31(9):2117-33.
2012: David Sebastián; Jessica Segalés; Eleonora Sorianello; Aurélie Waget; Matej Oresic; Rémy Burcelin; Peddinti Gopalacharyulu; María Isabel Hernández-Alvarez; Marc Liesa; Juan Pablo Muñoz; Manuel Palacín; José C Paz; Sara Pich; David Sala; Antonio Zorzano
Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(14):5523-8.
2012: Eleonora Sorianello; Francesc X Soriano; Marian Vila-Caballer; Vicente Andrés; Sergio Fernández-Pascual; Herminia González-Navarro; Deborah Naon; Manuel Palacín; José Portugal; Ana Sancho; Antonio Zorzano
The promoter activity of human Mfn2 depends on Sp1 in vascular smooth muscle cells.
Cardiovascular research 2012;94(1):38-47.
2012: Josep M Mercader; Sílvia Mora; Evarist Planet; Montserrat Puiggros; Vicent Ribas; Sergio Rodriguez-Cuenca; David Sebastian; Ayellet V Segrè; Eleonora Sorianello; Sílvia Bonàs-Guarch; Sorin Draghici; Josée Dupuis; Jose C Florez; Antonio Vidal-Puig; Chenjing Yang; Antonio Zorzano; David Torrents
Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems.
PLoS genetics 2012;8(12):e1003046.
2012: Michael R Breen; Marta Camps; Francisco Carvalho-Simoes; Antonio Zorzano; Paul F Pilch
Cholesterol depletion in adipocytes causes caveolae collapse concomitant with proteosomal degradation of cavin-2 in a switch-like fashion.
PloS one 2012;7(4):e34516.
2012: Ana Sancho; Endalkachew A Alemu; Javier U Chicote; Rob DeSalle; Jordi Duran; Antonio García-España; Terje Johansen; Trond Lamark; Maria J Macias; Caroline Mauvezin; Manuel Palacín; Miriam Royo; David Sala; Antonio Zorzano
DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription.
PloS one 2012;7(3):e34034.
2011: José Manuel Fernández-Real; Elodie Luche; José Maria Moreno-Navarrete; Sofia Pérez del Pulgar; Francesc Carmona Pontaque; Wifredo Ricart; Alex Sánchez; Matteo Serino; Eleonora Sorianello; Joan Vendrell; Aurelie Waget; Remy Burcelin; Matilde R Chacón; Antonio Zorzano
CD14 modulates inflammation-driven insulin resistance.
Diabetes 2011;60(8):2179-86.
2011: Roberto Bravo; Michael Bui; Mario Chiong; Jorge Ferreira; Joseph A Hill; Myriam Iglewski; Juan Pablo Munoz; Valentina Parra; Clara Quiroga; Andrea E Rodriguez; Beverly A Rothermel; Thomas Simmen; Gyorgy Szabadkai; Rodrigo Troncoso; Hugo E Verdejo; Jose Miguel Vicencio; Antonio Zorzano; Sergio Lavandero
Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress.
Journal of cell science 2011;124(Pt 13):2143-52.
2011: Gabriel R Linares; Wifredo Ricart; Weirong Xing; Antonio Zorzano; Bernhard Baumgartner; Hans Burghardt; Shin-Tai Chen; José Manuel Fernández-Real; Subburaman Mohan
Role of diabetes- and obesity-related protein in the regulation of osteoblast differentiation.
American journal of physiology. Endocrinology and metabolism 2011;301(1):E40-8.
2011: Juan Pablo Muñoz; Antonio Zorzano
Endoplasmic reticulum stress enters a Nogo zone.
Science translational medicine 2011;3(88):88ps26.
2011: Lukasz Kowalczyk; Mercè Ratera; Antonella Paladino; Paola Bartoccioni; Ekaitz Errasti-Murugarren; Eva Valencia; Guillem Portella; Susanna Bial; Antonio Zorzano; Ignacio Fita; Modesto Orozco; Xavier Carpena; José Luis Vázquez-Ibar; Manuel Palacín
Molecular basis of substrate-induced permeation by an amino acid antiporter.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(10):3935-40.
2010: Víctor A Francis; Antonio Zorzano; Aurelio A Teleman
dDOR is an EcR coactivator that forms a feed-forward loop connecting insulin and ecdysone signaling.
Current biology : CB 2010;20(20):1799-808.
2010: Paola Bartoccioni; César Del Rio; Merce Ratera; Lukasz Kowalczyk; Jocelyn M Baldwin; Antonio Zorzano; Matthias Quick; Stephen A Baldwin; José Luis Vázquez-Ibar; Manuel Palacín
Role of transmembrane domain 8 in substrate selectivity and translocation of SteT, a member of the L-amino acid transporter (LAT) family.
The Journal of biological chemistry 2010;285(37):28764-76.
2010: Antonio Zorzano; Marc Liesa; David Sebastián; Jessica Segalés; Manuel Palacín
Mitochondrial fusion proteins: dual regulators of morphology and metabolism.
Seminars in cell & developmental biology 2010;21(6):566-74.
2010: Josep Chillarón; Mariona Font-Llitjós; Joana Fort; Antonio Zorzano; David S Goldfarb; Virginia Nunes; Manuel Palacín
Pathophysiology and treatment of cystinuria.
Nature reviews. Nephrology 2010;6(7):424-34.
2010: Antonio Zorzano; María Isabel Hernández-Alvarez; Manuel Palacín; Geltrude Mingrone
Alterations in the mitochondrial regulatory pathways constituted by the nuclear co-factors PGC-1alpha or PGC-1beta and mitofusin 2 in skeletal muscle in type 2 diabetes.
Biochimica et biophysica acta 2010;1797(6-7):1028-33.
2010: Katrin Hahn; Merce Miranda; Víctor A Francis; Joan Vendrell; Antonio Zorzano; Aurelio A Teleman
PP2A regulatory subunit PP2A-B' counteracts S6K phosphorylation.
Cell metabolism 2010;11(5):438-44.
2010: Anna Gumà; Vicente Martínez-Redondo; Iliana López-Soldado; Carles Cantó; Antonio Zorzano
Emerging role of neuregulin as a modulator of muscle metabolism.
American journal of physiology. Endocrinology and metabolism 2010;298(4):E742-50.
2010: María Isabel Hernández-Alvarez; Hood Thabit; Nicole Burns; Syed Shah; Imad Brema; Mensud Hatunic; Francis Finucane; Marc Liesa; Chiara Chiellini; Deborah Naon; Antonio Zorzano; John J Nolan
Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1{alpha}/Mitofusin-2 regulatory pathway in response to physical activity.
Diabetes care 2010;33(3):645-51.
2010: Caroline Mauvezin; Meritxell Orpinell; Víctor A Francis; Francisco Mansilla; Jordi Duran; Vicent Ribas; Manuel Palacín; Patricia Boya; Aurelio A Teleman; Antonio Zorzano
The nuclear cofactor DOR regulates autophagy in mammalian and Drosophila cells.
EMBO reports 2010;11(1):37-44.
2009: Francisco Ortega; José M Moreno-Navarrete; Vicent Ribas; Eduardo Esteve; Jose I Rodriguez-Hermosa; Bartomeu Ruiz; Belén Peral; Wifredo Ricart; Antonio Zorzano; José Manuel Fernández-Real
Subcutaneous fat shows higher thyroid hormone receptor-alpha1 gene expression than omental fat.
Obesity (Silver Spring, Md.) 2009;17(12):2134-41.
2009: Antonio Zorzano; Marc Liesa; Manuel Palacín
Role of mitochondrial dynamics proteins in the pathophysiology of obesity and type 2 diabetes.
The international journal of biochemistry & cell biology 2009;41(10):1846-54.
2009: Antonio Zorzano; David Sebastián; Jessica Segalés; Manuel Palacín
The molecular machinery of mitochondrial fusion and fission: An opportunity for drug discovery?
Current opinion in drug discovery & development 2009;12(5):597-606.
2009: M I Hernández-Alvarez; C Chiellini; M Manco; D Naon; Marc Liesa; Manuel Palacín; G Mingrone; Antonio Zorzano
Genes involved in mitochondrial biogenesis/function are induced in response to bilio-pancreatic diversion in morbidly obese individuals with normal glucose tolerance but not in type 2 diabetic patients.
Diabetologia 2009;52(8):1618-27.
2009: Elena González-Muñoz; Carmen López-Iglesias; Maria Calvo; Manuel Palacín; Antonio Zorzano; Marta Camps
Caveolin-1 loss of function accelerates glucose transporter 4 and insulin receptor degradation in 3T3-L1 adipocytes.
Endocrinology 2009;150(8):3493-502.
2009: Marc Liesa; Manuel Palacín; Antonio Zorzano
Mitochondrial dynamics in mammalian health and disease.
Physiological reviews 2009;89(3):799-845.
2009: Antonio Zorzano
Regulation of mitofusin-2 expression in skeletal muscle.
Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme 2009;34(3):433-9.
2009: Carine Chavey; Gwendal Lazennec; Sylviane Lagarrigue; Cyrielle Clapé; Irena Iankova; Jacques Teyssier; Jean-Sébastien Annicotte; Julien Schmidt; Chikage Mataki; Hiroyasu Yamamoto; Rosario Sanches; Anna Guma; Vladimir Stich; Michaela Vitkova; Benedicte Jardin-Watelet; Eric Renard; Robert Strieter; Antoinette Tuthill; Gôkhan S Hotamisligil; antonio vidal-puig; Antonio Zorzano; Dominique Langin; Lluis Fajas
CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance.
Cell metabolism 2009;9(4):339-49.
2009: Francesc Yraola; Antonio Zorzano; Fernando Albericio; Miriam Royo
Structure-activity relationships of SSAO/VAP-1 arylalkylamine-based substrates.
ChemMedChem 2009;4(4):495-503.
2009: Antonio Zorzano; Manuel Palacín; Luc Marti; Silvia García-Vicente
Arylalkylamine vanadium salts as new anti-diabetic compounds.
Journal of inorganic biochemistry 2009;103(4):559-66.
2009: Antonio Zorzano; Marc Liesa; Manuel Palacín
Mitochondrial dynamics as a bridge between mitochondrial dysfunction and insulin resistance.
Archives of physiology and biochemistry 2009;115(1):1-12.
2008: Anna Duarri; Oscar Teijido; Tania López-Hernández; Gert C Scheper; Herve Barriere; Ilja Boor; Fernando Aguado; Antonio Zorzano; Manuel Palacín; Albert Martínez; Gergely L Lukacs; Marjo S van der Knaap; Virginia Nunes; Raúl Estévez
Molecular pathogenesis of megalencephalic leukoencephalopathy with subcortical cysts: mutations in MLC1 cause folding defects.
Human molecular genetics 2008;17(23):3728-39.
2008: Hans Burghardt; Abel López-Bermejo; Bernhard Baumgartner; Lourdes Ibáñez; Joan Vendrell; Wifredo Ricart; Manuel Palacín; José Manuel Fernández-Real; Antonio Zorzano
The nuclear receptor coactivator AIB3 is a modulator of HOMA beta-cell function in nondiabetic children.
Clinical endocrinology 2008;69(5):730-6.
2008: Paola Bartoccioni; Mònica Rius; Antonio Zorzano; Manuel Palacín; Josep Chillarón
Distinct classes of trafficking rBAT mutants cause the type I cystinuria phenotype.
Human molecular genetics 2008;17(12):1845-54.
2008: Valentina Parra; Verónica Eisner; Mario Chiong; Alfredo Criollo; Francisco Moraga; Alejandra Garcia; Steffen Härtel; Enrique Jaimovich; Antonio Zorzano; Cecilia Hidalgo; Sergio Lavandero
Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis.
Cardiovascular research 2008;77(2):387-97.
2008: Marc Liesa; Bárbara Borda-d'Agua; Gema Medina-Gómez; Christopher J Lelliott; José Carlos Paz; Manuel Rojo; Manuel Palacín; antonio vidal-puig; Antonio Zorzano
Mitochondrial fusion is increased by the nuclear coactivator PGC-1beta.
PloS one 2008;3(10):e3613.
2007: Ramón Martínez-Mármol; Miren David; Rosario Sanches; Meritxell Roura-Ferrer; Núria Villalonga; Eleonora Sorianello; Susan M Webb; Antonio Zorzano; Anna Gumà; Carmen Valenzuela; Antonio Felipe
Voltage-dependent Na+ channel phenotype changes in myoblasts. Consequences for cardiac repair.
Cardiovascular research 2007;76(3):430-41.
2007: Joana Fort; Laura R de la Ballina; Hans E Burghardt; Carles Ferrer-Costa; Javier Turnay; Cristina Ferrer-Orta; Isabel Usón; Antonio Zorzano; Juan Fernandez-Recio; Modesto Orozco; M Antonia Lizarbe; Ignacio Fita; Manuel Palacín
The structure of human 4F2hc ectodomain provides a model for homodimerization and electrostatic interaction with plasma membrane.
The Journal of biological chemistry 2007;282(43):31444-52.
2007: Carles Cantó; Sara Pich; José C Paz; Rosario Sanches; Vicente Martínez; Meritxell Orpinell; Manuel Palacín; Antonio Zorzano; Anna Gumà
Neuregulins increase mitochondrial oxidative capacity and insulin sensitivity in skeletal muscle cells.
Diabetes 2007;56(9):2185-93.
2007: Sandy Bour; Danièle Daviaud; Sandra Gres; Corinne Lefort; Danielle Prévot; Antonio Zorzano; Martin Wabitsch; Jean Sébastien Saulnier-Blache; Philippe Valet; Christian Carpéné
Adipogenesis-related increase of semicarbazide-sensitive amine oxidase and monoamine oxidase in human adipocytes.
Biochimie 2007;89(8):916-25.
2007: Francesc Yraola; Silvia García-Vicente; Luc Marti; Fernando Albericio; Antonio Zorzano; Miriam Royo
Understanding the mechanism of action of the novel SSAO substrate (C7NH10)6(V10O28).2H2O, a prodrug of peroxovanadate insulin mimetics.
Chemical biology & drug design 2007;69(6):423-8.
2007: Oscar Teijido; Ricardo P Casaroli-Marano; Tatjana Kharkovets; Fernando Aguado; Antonio Zorzano; Manuel Palacín; Eduardo Soriano; Albert Martínez; Raúl Estévez
Expression patterns of MLC1 protein in the central and peripheral nervous systems.
Neurobiology of disease 2007;26(3):532-45.
2007: Núria Reig; César del Rio; Fabio Casagrande; Mercè Ratera; Josep Lluis Gelpí; David Torrents; Peter J F Henderson; Hao Xie; Stephen A Baldwin; Antonio Zorzano; Dimitrios Fotiadis; Manuel Palacín
Functional and structural characterization of the first prokaryotic member of the L-amino acid transporter (LAT) family: a model for APC transporters.
The Journal of biological chemistry 2007;282(18):13270-81.
2007: María J Macías; Oscar Teijido; Giovanni Zifarelli; Pau Martin; Ximena Ramirez-Espain; Antonio Zorzano; Manuel Palacín; Michael Pusch; Raúl Estévez
Myotonia-related mutations in the distal C-terminus of ClC-1 and ClC-0 chloride channels affect the structure of a poly-proline helix.
The Biochemical journal 2007;403(1):79-87.
2007: Raquel Marin; Cristina M Ramírez; Miriam González; Elena González-Muñoz; Antonio Zorzano; Marta Camps; Rafael Alonso; Mario Díaz
Voltage-dependent anion channel (VDAC) participates in amyloid beta-induced toxicity and interacts with plasma membrane estrogen receptor alpha in septal and hippocampal neurons.
Molecular membrane biology 2007;24(2):148-60.
2007: Silvia García-Vicente; Francesc Yraola; Luc Marti; Elena González-Muñoz; María José García-Barrado; Carles Cantó; Anna Abella; Sandy Bour; Rafael Artuch; Cristina Sierra; Nuria Brandi; Christian Carpéné; Julio Moratinos; Marta Camps; Manuel Palacín; Xavier Testar; Anna Gumà; Fernando Albericio; Miriam Royo; Alec Mian; Antonio Zorzano
Oral insulin-mimetic compounds that act independently of insulin.
Diabetes 2007;56(2):486-93.
2007: Bernhard Baumgartner; Meritxell Orpinell; Jordi Duran; Vicent Ribas; Hans E Burghardt; Daniel Bach; Ana Victoria Villar; José C Paz; Meritxell González; Marta Camps; Josep Oriola; Francisca Rivera; Manuel Palacín; Antonio Zorzano
Identification of a novel modulator of thyroid hormone receptor-mediated action.
PloS one 2007;2(11):e1183.
2007: Esther Llagostera; Daniele Catalucci; Luc Marti; Marc Liesa; Marta Camps; Theodore P Ciaraldi; Richard P Kondo; Sita Reddy; Wolfgang H Dillmann; Manuel Palacin; Antonio Zorzano; Pilar Ruiz-Lozano; Ramon Gomis; Perla Kaliman
Role of myotonic dystrophy protein kinase (DMPK) in glucose homeostasis and muscle insulin action.
PloS one 2007;2(11):e1134.
2006: Francesc Yraola; Silvia García-Vicente; Juan Fernandez-Recio; Fernando Albericio; Antonio Zorzano; Luc Marti; Miriam Royo
New efficient substrates for semicarbazide-sensitive amine oxidase/VAP-1 enzyme: analysis by SARs and computational docking.
Journal of medicinal chemistry 2006;49(21):6197-208.
2006: Esperanza Fernández; Maite Jiménez-Vidal; María Calvo; Antonio Zorzano; Francesc Tebar; Manuel Palacín; Josep Chillarón
The structural and functional units of heteromeric amino acid transporters. The heavy subunit rBAT dictates oligomerization of the heteromeric amino acid transporters.
The Journal of biological chemistry 2006;281(36):26552-61.
2006: Carles Cantó; Alexander V Chibalin; Brian R Barnes; Stephan Glund; Elisabeth Suárez; Jeffrey W Ryder; Manuel Palacín; Juleen R Zierath; Antonio Zorzano; Anna Gumà
Neuregulins mediate calcium-induced glucose transport during muscle contraction.
The Journal of biological chemistry 2006;281(31):21690-7.
2006: Antonio Zorzano; Marta Camps
Isolation of T-tubules from skeletal muscle.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2006;Chapter 3():Unit 3.24.
2006: Antonio Zorzano; Sara Pich
What is the biological significance of the two mitofusin proteins present in the outer mitochondrial membrane of mammalian cells?
IUBMB life 2006;58(7):441-3.
2006: Tomàs Santalucía; Manuel Palacín; Antonio Zorzano
T3 strongly regulates GLUT1 and GLUT3 mRNA in cerebral cortex of hypothyroid rat neonates.
Molecular and cellular endocrinology 2006;251(1-2):9-16.
2006: C Duffaut; Sandy Bour; Danielle Prévot; Luc Marti; Xavier Testar; Antonio Zorzano; Christian Carpéné
Prolonged treatment with the beta3-adrenergic agonist CL 316243 induces adipose tissue remodeling in rat but not in guinea pig: 2) modulation of glucose uptake and monoamine oxidase activity.
Journal of physiology and biochemistry 2006;62(2):101-11.
2006: Francesc X Soriano; Marc Liesa; Daniel Bach; David C Chan; Manuel Palacín; Antonio Zorzano
Evidence for a mitochondrial regulatory pathway defined by peroxisome proliferator-activated receptor-gamma coactivator-1 alpha, estrogen-related receptor-alpha, and mitofusin 2.
Diabetes 2006;55(6):1783-91.
2006: Lorena Martín Jaular; Mònica Comalada; Luc Marti; Ellen I Closs; Carol L MacLeod; Rafael Martín Del Río; Antonio Zorzano; Manuel Modolell; Antonio Celada; Manuel Palacín; Joan Bertran
Granulocyte-macrophage colony-stimulating factor increases L-arginine transport through the induction of CAT2 in bone marrow-derived macrophages.
American journal of physiology. Cell physiology 2006;290(5):C1364-72.
2005: Daniel Bach; Deborah Naon; Sara Pich; Francesc X Soriano; Nathalie Vega; Jennifer Rieusset; Martine Laville; Christelle Guillet; Yves Boirie; Harriet Wallberg-Henriksson; Melania Manco; Menotti Calvani; Marco Castagneto; Manuel Palacín; Geltrude Mingrone; Juleen R Zierath; Hubert Vidal; Antonio Zorzano
Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6.
Diabetes 2005;54(9):2685-93.
2005: Romain Cartoni; Bertrand Léger; M Benjamin Hock; Manu Praz; Antoinette Crettenand; Sara Pich; Jean-Luc Ziltener; François Luthi; Olivier Dériaz; Antonio Zorzano; Charles Gobelet; Anastasia Kralli; Aaron P Russell
Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise.
The Journal of physiology 2005;567(Pt 1):349-58.
2005: Silvia García-Vicente; Anna Abella; Nathalie Viguerie; A Ros-Baró; Marta Camps; Xavier Testar; Manuel Palacín; Antonio Zorzano; Luc Marti
The release of soluble VAP-1/SSAO by 3T3-L1 adipocytes is stimulated by isoproterenol and low concentrations of TNFalpha.
Journal of physiology and biochemistry 2005;61(2):395-401.
2005: Sara Pich; Daniel Bach; Paz Briones; Marc Liesa; Marta Camps; Xavier Testar; Manuel Palacín; Antonio Zorzano
The Charcot-Marie-Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system.
Human molecular genetics 2005;14(11):1405-15.
2005: Esperanza Fernández; David Torrents; Antonio Zorzano; Manuel Palacín; Josep Chillarón
Identification and functional characterization of a novel low affinity aromatic-preferring amino acid transporter (arpAT). One of the few proteins silenced during primate evolution.
The Journal of biological chemistry 2005;280(19):19364-72.
2005: Tomàs Santalucía; Manuela Sánchez-Feutrie; Leanne E Felkin; Pankaj Bhavsar; Paul J R Barton; Antonio Zorzano; Magdi H Yacoub; Nigel J Brand
Phenylephrine requires the TATA box to activate transcription of GLUT1 in neonatal rat cardiac myocytes.
Journal of molecular and cellular cardiology 2005;38(4):677-84.
2005: Manuel Palacín; Virginia Nunes; Mariona Font-Llitjós; Maite Jiménez-Vidal; Joana Fort; Emma Gasol; Manuel Pineda; Lidia Feliubadaló; Josep Chillarón; Antonio Zorzano
The genetics of heteromeric amino acid transporters.
Physiology (Bethesda, Md.) 2005;20():112-24.
2005: Susanna Bodoy; Lorena Martín Jaular; Antonio Zorzano; Manuel Palacín; Raúl Estévez; Joan Bertran
Identification of LAT4, a novel amino acid transporter with system L activity.
The Journal of biological chemistry 2005;280(12):12002-11.
2005: Perla Kaliman; Daniele Catalucci; Jason T Lam; Richard P Kondo; José Carlos Paz Gutiérrez; Sita Reddy; Manuel Palacín; Antonio Zorzano; Kenneth R Chien; Pilar Ruiz-Lozano
Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum.
The Journal of biological chemistry 2005;280(9):8016-21.
2005: Antonio Zorzano; Manuel Palacín; Anna Gumà
Mechanisms regulating GLUT4 glucose transporter expression and glucose transport in skeletal muscle.
Acta physiologica Scandinavica 2005;183(1):43-58.
2004: Oscar Teijido; Albert Martínez; Michael Pusch; Antonio Zorzano; Eduardo Soriano; Jose Antonio Del Río; Manuel Palacín; Raúl Estévez
Localization and functional analyses of the MLC1 protein involved in megalencephalic leukoencephalopathy with subcortical cysts.
Human molecular genetics 2004;13(21):2581-94.
2004: Manuel Pineda; Mariona Font; Maria Teresa Bassi; Marta Manzoni; Giuseppe Borsani; Valeria Marigo; Esperanza Fernández; Rafael Martín del Río; Jesús Purroy; Antonio Zorzano; Virginia Nunes; Manuel Palacín
The amino acid transporter asc-1 is not involved in cystinuria.
Kidney international 2004;66(4):1453-64.
2004: Luc Marti; Anna Abella; Xavier de la Cruz; Silvia García-Vicente; Mercedes Unzeta; Christian Carpéné; Manuel Palacín; Xavier Testar; Modesto Orozco; Antonio Zorzano
Exploring the binding mode of semicarbazide-sensitive amine oxidase/VAP-1: identification of novel substrates with insulin-like activity.
Journal of medicinal chemistry 2004;47(20):4865-74.
2004: Emma Gasol; Maite Jiménez-Vidal; Josep Chillarón; Antonio Zorzano; Manuel Palacín
Membrane topology of system xc- light subunit reveals a re-entrant loop with substrate-restricted accessibility.
The Journal of biological chemistry 2004;279(30):31228-36.
2004: Antonio Zorzano; Daniel Bach; Sara Pich; Manuel Palacín
[Role of novel mitochondrial proteins in energy balance].
Revista de medicina de la Universidad de Navarra 2004;48(2):30-5.
2004: Manuel Palacín; Joan Bertran; Josep Chillarón; Raúl Estévez; Antonio Zorzano
Lysinuric protein intolerance: mechanisms of pathophysiology.
Molecular genetics and metabolism 2004;81 Suppl 1():S27-37.
2004: Craig Stolen; Rami Madanat; Luc Marti; Seppo Kari; Gennady G Yegutkin; Hannu Sariola; Antonio Zorzano; Sirpa Jalkanen
Semicarbazide sensitive amine oxidase overexpression has dual consequences: insulin mimicry and diabetes-like complications.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(6):702-4.
2004: Joost J F P Luiken; Susan L M Coort; Debby P Y Koonen; Dick J van der Horst; Arend Bonen; Antonio Zorzano; Jan F C Glatz
Regulation of cardiac long-chain fatty acid and glucose uptake by translocation of substrate transporters.
Pflügers Archiv : European journal of physiology 2004;448(1):1-15.
2004: Carles Cantó; Elisabeth Suárez; Jose Lizcano; Elisenda Griñó; Peter R Shepherd; Lee G D Fryer; David Carling; Joan Bertran; Manuel Palacín; Antonio Zorzano; Anna Gumà
Neuregulin signaling on glucose transport in muscle cells.
The Journal of biological chemistry 2004;279(13):12260-8.
2004: Maite Jiménez-Vidal; Emma Gasol; Antonio Zorzano; Virginia Nunes; Manuel Palacín; Josep Chillarón
Thiol modification of cysteine 327 in the eighth transmembrane domain of the light subunit xCT of the heteromeric cystine/glutamate antiporter suggests close proximity to the substrate binding site/permeation pathway.
The Journal of biological chemistry 2004;279(12):11214-21.
2004: Manuela Sánchez-Feutrie; Tomàs Santalucía; C Fandos; Véronique Noé; Francesc Viñals; Nigel J Brand; Carlos Ciudad; Manuel Palacín; Antonio Zorzano
A novel muscle DNA-binding activity in the GLUT1 promoter.
Cellular and molecular life sciences : CMLS 2004;61(6):709-20.
2004: Virgile Visentin; Danielle Prévot; Véronique Durand De Saint Front; Nathalie Morin-Cussac; Claire Thalamas; Jean Galitzky; Philippe Valet; Antonio Zorzano; Christian Carpéné
Alteration of amine oxidase activity in the adipose tissue of obese subjects.
Obesity research 2004;12(3):547-55.
2004: Anna Abella; Silvia García-Vicente; Nathalie Viguerie; A Ros-Baró; Marta Camps; Manuel Palacín; Antonio Zorzano; Luc Marti
Adipocytes release a soluble form of VAP-1/SSAO by a metalloprotease-dependent process and in a regulated manner.
Diabetologia 2004;47(3):429-38.
2004: Manuel Pineda; Carsten A Wagner; Angelika Bröer; Paul A Stehberger; Simone Kaltenbach; Josep Lluis Gelpí; Rafael Martín Del Río; Antonio Zorzano; Manuel Palacín; Florian Lang; Stefan Broer
Cystinuria-specific rBAT(R365W) mutation reveals two translocation pathways in the amino acid transporter rBAT-b0,+AT.
The Biochemical journal 2004;377(Pt 3):665-74.
2003: Manuela Sánchez-Feutrie; Francesc Viñals; Manuel Palacín; Antonio Zorzano
Identification of a novel proliferation-dependent C-rich element that mediates inhibition of the rat GLUT1 promoter.
Gene 2003;322():47-55.
2003: Horacio Moreno; Antonio L Serrano; Tomàs Santalucía; Anna Gumá; Carles Cantó; Nigel J Brand; Manuel Palacin; Stefano Schiaffino; Antonio Zorzano
Differential regulation of the muscle-specific GLUT4 enhancer in regenerating and adult skeletal muscle.
The Journal of biological chemistry 2003;278(42):40557-64.
2003: Anna Abella; Luc Marti; Christian Carpéné; Manuel Palacín; Xavier Testar; Antonio Zorzano
Stimulation of glucose transport by semicarbazide-sensitive amine oxidase activity in adipocytes from diabetic rats.
Journal of physiology and biochemistry 2003;59(3):153-60.
2003: Lidia Feliubadaló; Maria L Arbonés; Sandra Mañas; Josep Chillarón; Joana Visa; Margot Rodés; Ferran Rousaud; Antonio Zorzano; Manuel Palacín; Virginia Nunes
Slc7a9-deficient mice develop cystinuria non-I and cystine urolithiasis.
Human molecular genetics 2003;12(17):2097-108.
2003: Daniel Bach; Sara Pich; Francesc X Soriano; Nathalie Vega; Bernhard Baumgartner; Josep Oriola; Jens R Daugaard; Jorge Lloberas; Marta Camps; Juleen R Zierath; Rémi Rabasa-Lhoret; Harriet Wallberg-Henriksson; Martine Laville; Manuel Palacín; Hubert Vidal; Francisca Rivera; Martin Brand; Antonio Zorzano
Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity.
The Journal of biological chemistry 2003;278(19):17190-7.
2003: Maribel Grande; Elisabeth Suàrez; Rubén Vicente; Carles Cantó; Mireia Coma; Michael M Tamkun; Antonio Zorzano; Anna Gumà; Antonio Felipe
Voltage-dependent K+ channel beta subunits in muscle: differential regulation during postnatal development and myogenesis.
Journal of cellular physiology 2003;195(2):187-93.
2003: Antonio Zorzano; Anna Abella; Luc Marti; Christian Carpéné; Manuel Palacín; Xavier Testar
Semicarbazide-sensitive amine oxidase activity exerts insulin-like effects on glucose metabolism and insulin-signaling pathways in adipose cells.
Biochimica et biophysica acta 2003;1647(1-2):3-9.
2003: Anna Abella; Luc Marti; Marta Camps; Marc Claret; J Fernández-Alvarez; Ramon Gomis; Anna Gumà; Nathalie Viguerie; Christian Carpéné; Manuel Palacín; Xavier Testar; Antonio Zorzano
Semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 activity exerts an antidiabetic action in Goto-Kakizaki rats.
Diabetes 2003;52(4):1004-13.
2003: Esperanza Fernández; David Torrents; Josep Chillarón; Rafael Martín Del Río; Antonio Zorzano; Manuel Palacín
Basolateral LAT-2 has a major role in the transepithelial flux of L-cystine in the renal proximal tubule cell line OK.
Journal of the American Society of Nephrology : JASN 2003;14(4):837-47.
2003: Antonio Zorzano; Perla Kaliman; Anna Gumà; Manuel Palacín
Intracellular signals involved in the effects of insulin-like growth factors and neuregulins on myofibre formation.
Cellular signalling 2003;15(2):141-9.
2002: Nathalie Morin; Virgile Visentin; Denis Calise; Luc Marti; Antonio Zorzano; Xavier Testar; Philippe Valet; Yvan Fischer; Christian Carpéné
Tyramine stimulates glucose uptake in insulin-sensitive tissues in vitro and in vivo via its oxidation by amine oxidases.
The Journal of pharmacology and experimental therapeutics 2002;303(3):1238-47.
2002: Joost J F P Luiken; Debby P Y Koonen; Jodil Willems; Antonio Zorzano; Christoph Becker; Yvan Fischer; Narendra Tandon; Ger J van der Vusse; Arend Bonen; Jan F C Glatz
Insulin stimulates long-chain fatty acid utilization by rat cardiac myocytes through cellular redistribution of FAT/CD36.
Diabetes 2002;51(10):3113-9.
2002: Luca Dello Strologo; Elon Pras; Claudia Pontesilli; Ercole Beccia; Vittorino Ricci-Barbini; Luisa de Sanctis; Alberto Ponzone; Michele Gallucci; Luigi Bisceglia; Leopoldo Zelante; Maite Jimenez-Vidal; Mariona Font; Antonio Zorzano; Ferran Rousaud; Virginia Nunes; Paolo Gasparini; Manuel Palacín; Gianfranco Rizzoni
Comparison between SLC3A1 and SLC7A9 cystinuria patients and carriers: a need for a new classification.
Journal of the American Society of Nephrology : JASN 2002;13(10):2547-53.
2002: Núria Reig; Josep Chillarón; Paola Bartoccioni; Esperanza Fernández; Annie Bendahan; Antonio Zorzano; Baruch Kanner; Manuel Palacín; Joan Bertran
The light subunit of system b(o,+) is fully functional in the absence of the heavy subunit.
The EMBO journal 2002;21(18):4906-14.
2002: Esperanza Fernández; Montserrat Carrascal; Ferran Rousaud; Joaquín Abián; Antonio Zorzano; Manuel Palacín; Josep Chillarón
rBAT-b(0,+)AT heterodimer is the main apical reabsorption system for cystine in the kidney.
American journal of physiology. Renal physiology 2002;283(3):F540-8.
2002: Eva Tomás; Antonio Zorzano; Neil B Ruderman
Exercise and insulin signaling: a historical perspective.
Journal of applied physiology (Bethesda, Md. : 1985) 2002;93(2):765-72.
2002: Marta Carrasco; Judith Canicio; Manuel Palacín; Antonio Zorzano; Perla Kaliman
Identification of intracellular signaling pathways that induce myotonic dystrophy protein kinase expression during myogenesis.
Endocrinology 2002;143(8):3017-25.
2001: C Becker; L Sevilla; E Tomàs; M Palacin; Antonio Zorzano; Yvan Fischer
The endosomal compartment is an insulin-sensitive recruitment site for GLUT4 and GLUT1 glucose transporters in cardiac myocytes.
Endocrinology 2001;142(12):5267-76.
2001: Josep Chillarón; Ramón Roca; Carmen Galvez; Antonio Zorzano; Manuel Palacín
Heteromeric amino acid transporters: biochemistry, genetics, and physiology.
American journal of physiology. Renal physiology 2001;281(6):F995-1018.
2001: Tomàs Santalucía; H Moreno; Manuel Palacín; Magdi H Yacoub; Nigel J Brand; Antonio Zorzano
A novel functional co-operation between MyoD, MEF2 and TRalpha1 is sufficient for the induction of GLUT4 gene transcription.
Journal of molecular biology 2001;314(2):195-204.
2001: A Ros-Baro; Carmen Lopez-Iglesias; S Peiro; David Bellido; Manuel Palacin; Antonio Zorzano; Marta Camps
Lipid rafts are required for GLUT4 internalization in adipose cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(21):12050-5.
2001: Luc Marti; Anna Abella; Christian Carpéné; Manuel Palacín; Xavier Testar; Antonio Zorzano
Combined treatment with benzylamine and low dosages of vanadate enhances glucose tolerance and reduces hyperglycemia in streptozotocin-induced diabetic rats.
Diabetes 2001;50(9):2061-8.
2001: Emi Fontana; Jeremie Boucher; Luc Marti; Jose Lizcano; Xavier Testar; Antonio Zorzano; Christian Carpéné
Amine oxidase substrates mimic several of the insulin effects on adipocyte differentiation in 3T3 F442A cells.
The Biochemical journal 2001;356(Pt 3):769-77.
2001: E Tomàs; L Sevilla; Manuel Palacín; Antonio Zorzano
The insulin-sensitive GLUT4 storage compartment is a postendocytic and heterogeneous population recruited by acute exercise.
Biochemical and biophysical research communications 2001;284(2):490-5.
2001: Judith Canicio; Pilar Ruiz-Lozano; M Carrasco; Manuel Palacin; K Chien; Antonio Zorzano; Perla Kaliman
Nuclear factor kappa B-inducing kinase and Ikappa B kinase-alpha signal skeletal muscle cell differentiation.
The Journal of biological chemistry 2001;276(23):20228-33.
2001: Elisabeth Suárez; Daniel Bach; Joan Cadefau; Manuel Palacin; Antonio Zorzano; Anna Gumá
A novel role of neuregulin in skeletal muscle. Neuregulin stimulates glucose uptake, glucose transporter translocation, and transporter expression in muscle cells.
The Journal of biological chemistry 2001;276(21):18257-64.
2001: Maria Teresa Bassi; Emma Gasol; Marta Manzoni; Manuel Pineda; M Riboni; R Martín; Antonio Zorzano; Giuseppe Borsani; Manuel Palacín
Identification and characterisation of human xCT that co-expresses, with 4F2 heavy chain, the amino acid transport activity system xc-.
Pflügers Archiv : European journal of physiology 2001;442(2):286-96.
2001: Nathalie Morin; Jose Lizcano; Emi Fontana; Luc Marti; Fatima Smih; Philippe ROUET; Danielle Prévot; Antonio Zorzano; Mercedes Unzeta; Christian Carpéné
Semicarbazide-sensitive amine oxidase substrates stimulate glucose transport and inhibit lipolysis in human adipocytes.
The Journal of pharmacology and experimental therapeutics 2001;297(2):563-72.
2001: Mariona Font; Lidia Feliubadaló; X Estivill; Virginia Nunes; E Golomb; Y Kreiss; Elon Pras; Luigi Bisceglia; A P d'Adamo; Leopoldo Zelante; Paolo Gasparini; Maria Teresa Bassi; A L George ; Marta Manzoni; M Riboni; Andrea Ballabio; Giuseppe Borsani; Núria Reig; Esperanza Fernández; Antonio Zorzano; Joan Bertran; Manuel Palacín
Functional analysis of mutations in SLC7A9, and genotype-phenotype correlation in non-Type I cystinuria.
Human molecular genetics 2001;10(4):305-16.
2001: Manuel Palacin; Esperanza Fernández; Josep Chillarón; Antonio Zorzano
The amino acid transport system b(o,+) and cystinuria.
Molecular membrane biology 2001;18(1):21-6.
2000: Manuel Palacín; Joan Bertran; Antonio Zorzano
Heteromeric amino acid transporters explain inherited aminoacidurias.
Current opinion in nephrology and hypertension 2000;9(5):547-53.
2000: G Enrique-Tarancón; I Castan; Nathalie Morin; Luc Marti; Anna Abella; Marta Camps; R Casamitjana; Manuel Palacín; Xavier Testar; Eva Degerman; Christian Carpéné; Antonio Zorzano
Substrates of semicarbazide-sensitive amine oxidase co-operate with vanadate to stimulate tyrosine phosphorylation of insulin-receptor-substrate proteins, phosphoinositide 3-kinase activity and GLUT4 translocation in adipose cells.
The Biochemical journal 2000;350 Pt 1():171-80.
2000: Antonio Zorzano; C Fandos; Manuel Palacín
Role of plasma membrane transporters in muscle metabolism.
The Biochemical journal 2000;349 Pt 3():667-88.
2000: Juha Mykkänen; David Torrents; Manuel Pineda; Marta Camps; M E Yoldi; Nina Horelli-Kuitunen; Kirsi Huoponen; M Heinonen; Jaana Oksanen; Olli Simell; Marja-Liisa Savontaus; Antonio Zorzano; Manuel Palacín; Pertti Aula
Functional analysis of novel mutations in y(+)LAT-1 amino acid transporter gene causing lysinuric protein intolerance (LPI).
Human molecular genetics 2000;9(3):431-8.
1999: C Fandos; Manuela Sánchez-Feutrie; Tomàs Santalucía; Francesc Viñals; Joan Cadefau; Anna Gumà; Roser Cussó; Perla Kaliman; Judith Canicio; Manuel Palacín; Antonio Zorzano
GLUT1 glucose transporter gene transcription is repressed by Sp3. Evidence for a regulatory role of Sp3 during myogenesis.
Journal of molecular biology 1999;294(1):103-19.
1999: Lidia Feliubadaló; Luigi Bisceglia; Mariona Font; Luca Dello Strologo; Ercole Beccia; M Arslan-Kirchner; B Steinmann; Leopoldo Zelante; X Estivill; Antonio Zorzano; Manuel Palacín; Paolo Gasparini; Virginia Nunes
Recombinant families locate the gene for non-type I cystinuria between markers C13 and D19S587 on chromosome 19q13.1.
Genomics 1999;60(3):362-5.
1999: Manuel Pineda; Esperanza Fernández; David Torrents; Raúl Estévez; C López; Marta Camps; Jorge Lloberas; Antonio Zorzano; Manuel Palacín
Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids.
The Journal of biological chemistry 1999;274(28):19738-44.
1999: Tomàs Santalucía; K R Boheler; Nigel J Brand; U Sahye; C Fandos; Francesc Viñals; J Ferré; Xavier Testar; Manuel Palacín; Antonio Zorzano
Factors involved in GLUT-1 glucose transporter gene transcription in cardiac muscle.
The Journal of biological chemistry 1999;274(25):17626-34.
1999: Perla Kaliman; Judith Canicio; Xavier Testar; Manuel Palacín; Antonio Zorzano
Insulin-like growth factor-II, phosphatidylinositol 3-kinase, nuclear factor-kappaB and inducible nitric-oxide synthase define a common myogenic signaling pathway.
The Journal of biological chemistry 1999;274(25):17437-44.
1999: Francesc Viñals; A Gross; Xavier Testar; Manuel Palacín; P Rösen; Antonio Zorzano
High glucose concentrations inhibit glucose phosphorylation, but not glucose transport, in human endothelial cells.
Biochimica et biophysica acta 1999;1450(2):119-29.
1999: David Torrents; Juha Mykkänen; Manuel Pineda; Lidia Feliubadaló; Raúl Estévez; Rafael de Cid; P Sanjurjo; Antonio Zorzano; Virginia Nunes; Kirsi Huoponen; A Reinikainen; Olli Simell; Marja-Liisa Savontaus; Pertti Aula; Manuel Palacín
Identification of SLC7A7, encoding y+LAT-1, as the lysinuric protein intolerance gene.
Nature genetics 1999;21(3):293-6.
1999: L Sevilla; Anna Gumà; P Muñoz; Xavier Testar; Manuel Palacín; Antonio Zorzano
Benfluorex improves muscle insulin responsiveness in middle-aged rats previously subjected to long-term high-fat feeding.
Life sciences 1999;64(1):25-36.
1998: David Torrents; Raúl Estévez; Manuel Pineda; Esperanza Fernández; Jorge Lloberas; Y B Shi; Antonio Zorzano; Manuel Palacín
Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L. A candidate gene for lysinuric protein intolerance.
The Journal of biological chemistry 1998;273(49):32437-45.
1998: Judith Canicio; E Gallardo; I Illa; Xavier Testar; Manuel Palacín; Antonio Zorzano; Perla Kaliman
p70 S6 kinase activation is not required for insulin-like growth factor-induced differentiation of rat, mouse, or human skeletal muscle cells.
Endocrinology 1998;139(12):5042-9.
1998: Antonio Zorzano; T Santalucia; Manuel Palacín; Anna Gumà; Marta Camps
Searching for ways to upregulate GLUT4 glucose transporter expression in muscle.
General pharmacology 1998;31(5):705-13.
1998: Manuel Palacín; Raúl Estévez; Joan Bertran; Antonio Zorzano
Molecular biology of mammalian plasma membrane amino acid transporters.
Physiological reviews 1998;78(4):969-1054.
1998: Raúl Estévez; Marta Camps; AM Rojas; Xavier Testar; Rosa Devés; M A Hediger; Antonio Zorzano; Manuel Palacín
The amino acid transport system y+L/4F2hc is a heteromultimeric complex.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(13):1319-29.
1998: Antonio Zorzano; L Sevilla; E Tomàs; Marta Camps; Anna Gumà; Manuel Palacín
Trafficking pathway of GLUT4 glucose transporters in muscle (review).
International journal of molecular medicine 1998;2(3):263-71.
1998: Manuel Palacín; Raúl Estévez; Antonio Zorzano
Cystinuria calls for heteromultimeric amino acid transporters.
Current opinion in cell biology 1998;10(4):455-61.
1998: Susanna Baqué; Eulàlia Montell; Marta Camps; Joan J Guinovart; Antonio Zorzano; Anna M Gómez-Foix
Overexpression of glycogen phosphorylase increases GLUT4 expression and glucose transport in cultured skeletal human muscle.
Diabetes 1998;47(8):1185-92.
1998: M Zhou; L Sevilla; Gino Vallega; P Chen; M Palacin; Antonio Zorzano; Paul F Pilch; Konstantin V Kandror
Insulin-dependent protein trafficking in skeletal muscle cells.
The American journal of physiology 1998;275(2 Pt 1):E187-96.
1998: G Enrique-Tarancón; Luc Marti; Nathalie Morin; Jose Lizcano; Mercedes Unzeta; L Sevilla; Marta Camps; Manuel Palacín; Xavier Testar; Christian Carpéné; Antonio Zorzano
Role of semicarbazide-sensitive amine oxidase on glucose transport and GLUT4 recruitment to the cell surface in adipose cells.
The Journal of biological chemistry 1998;273(14):8025-32.
1998: Luc Marti; Nathalie Morin; G Enrique-Tarancon; D Prevot; Max Lafontan; Xavier Testar; Antonio Zorzano; Christian Carpéné
Tyramine and vanadate synergistically stimulate glucose transport in rat adipocytes by amine oxidase-dependent generation of hydrogen peroxide.
The Journal of pharmacology and experimental therapeutics 1998;285(1):342-9.
1998: Perla Kaliman; Judith Canicio; Peter R Shepherd; Caroline A Beeton; Xavier Testar; Manuel Palacín; Antonio Zorzano
Insulin-like growth factors require phosphatidylinositol 3-kinase to signal myogenesis: dominant negative p85 expression blocks differentiation of L6E9 muscle cells.
Molecular endocrinology (Baltimore, Md.) 1998;12(1):66-77.
1997: Antonio Zorzano; L Sevilla; Marta Camps; C Becker; J Meyer; H Kammermeier; P Muñoz; Anna Gumà; Xavier Testar; Manuel Palacín; Juan Blasi; Yvan Fischer
Regulation of glucose transport, and glucose transporters expression and trafficking in the heart: studies in cardiac myocytes.
The American journal of cardiology 1997;80(3A):65A-76A.
1997: Antonio Zorzano; L Sevilla; E Tomàs; Anna Gumà; Manuel Palacín; Yvan Fischer
GLUT4 trafficking in cardiac and skeletal muscle: isolation and characterization of distinct intracellular GLUT4-containing vesicle populations.
Biochemical Society transactions 1997;25(3):968-74.
1997: L Sevilla; E Tomàs; P Muñoz; Anna Gumá; Yvan Fischer; J Thomas; B Ruiz-Montasell; Xavier Testar; Manuel Palacín; Juan Blasi; Antonio Zorzano
Characterization of two distinct intracellular GLUT4 membrane populations in muscle fiber. Differential protein composition and sensitivity to insulin.
Endocrinology 1997;138(7):3006-15.
1997: L Sevilla; Anna Gumà; G Enrique-Tarancón; S Mora; P Muñoz; Manuel Palacín; Xavier Testar; Antonio Zorzano
Chronic high-fat feeding and middle-aging reduce in an additive fashion Glut4 expression in skeletal muscle and adipose tissue.
Biochemical and biophysical research communications 1997;235(1):89-93.
1997: Francesc Viñals; M Camps; Xavier Testar; Manuel Palacín; Antonio Zorzano
Effect of cations on the tyrosine kinase activity of the insulin receptor: inhibition by fluoride is magnesium dependent.
Molecular and cellular biochemistry 1997;171(1-2):69-73.
1997: S Mora; Ingrid Monden; Antonio Zorzano; Konrad Keller
Heterologous expression of rab4 reduces glucose transport and GLUT4 abundance at the cell surface in oocytes.
The Biochemical journal 1997;324 ( Pt 2)():455-9.
1997: Francesc Viñals; J Ferré; C Fandos; T Santalucia; Xavier Testar; Manuel Palacín; Antonio Zorzano
Cyclic adenosine 3',5'-monophosphate regulates GLUT4 and GLUT1 glucose transporter expression and stimulates transcriptional activity of the GLUT1 promoter in muscle cells.
Endocrinology 1997;138(6):2521-9.
1997: Francesc Viñals; C Fandos; T Santalucia; J Ferré; Xavier Testar; Manuel Palacín; Antonio Zorzano
Myogenesis and MyoD down-regulate Sp1. A mechanism for the repression of GLUT1 during muscle cell differentiation.
The Journal of biological chemistry 1997;272(20):12913-21.
1997: Josep Chillarón; Raúl Estévez; I Samarzija; S Waldegger; Xavier Testar; Florian Lang; Antonio Zorzano; A Busch; Manuel Palacín
An intracellular trafficking defect in type I cystinuria rBAT mutants M467T and M467K.
The Journal of biological chemistry 1997;272(14):9543-9.
1997: Yvan Fischer; J Thomas; L Sevilla; P Muñoz; C Becker; G Holman; I J Kozka; Manuel Palacín; Xavier Testar; H Kammermeier; Antonio Zorzano
Insulin-induced recruitment of glucose transporter 4 (GLUT4) and GLUT1 in isolated rat cardiac myocytes. Evidence of the existence of different intracellular GLUT4 vesicle populations.
The Journal of biological chemistry 1997;272(11):7085-92.
1997: Luigi Bisceglia; M J Calonge; Angela Totaro; Lidia Feliubadaló; Salvatore Melchionda; J García; Xavier Testar; Michele Gallucci; Alberto Ponzone; Leopoldo Zelante; Antonio Zorzano; X Estivill; Paolo Gasparini; Virginia Nunes; Manuel Palacín
Localization, by linkage analysis, of the cystinuria type III gene to chromosome 19q13.1.
American journal of human genetics 1997;60(3):611-6.
1996: P Muñoz; J Chillarón; Marta Camps; A Castelló; M Furriols; Xavier Testar; Manuel Palacín; Antonio Zorzano
Evidence for posttranscriptional regulation of GLUT4 expression in muscle and adipose tissue from streptozotocin-induced diabetic and benfluorex-treated rats.
Biochemical pharmacology 1996;52(11):1665-73.
1996: J Purroy; Luigi Bisceglia; M J Calonge; Leopoldo Zelante; Xavier Testar; Antonio Zorzano; Xavier Estivill; Manuel Palacín; Virginia Nunes; Paolo Gasparini
Genomic structure and organization of the human rBAT gene (SLC3A1).
Genomics 1996;37(2):249-52.
1996: Luigi Bisceglia; M J Calonge; Luca Dello Strologo; Gianfranco Rizzoni; Luisa de Sanctis; M Gallucci; E Beccia; Xavier Testar; Antonio Zorzano; Xavier Estivill; Leopoldo Zelante; M Palacin; Paolo Gasparini; Virginia Nunes
Molecular analysis of the cystinuria disease gene: identification of four new mutations, one large deletion, and one polymorphism.
Human genetics 1996;98(4):447-51.
1996: Perla Kaliman; Francesc Viñals; Xavier Testar; Manuel Palacín; Antonio Zorzano
Phosphatidylinositol 3-kinase inhibitors block differentiation of skeletal muscle cells.
The Journal of biological chemistry 1996;271(32):19146-51.
1996: J Chillarón; Raúl Estévez; C Mora; Carsten A Wagner; Hartmut Suessbrich; Florian Lang; J L Gelpí; Xavier Testar; Andreas E Busch; Antonio Zorzano; Manuel Palacín
Obligatory amino acid exchange via systems bo,+-like and y+L-like. A tertiary active transport mechanism for renal reabsorption of cystine and dibasic amino acids.
The Journal of biological chemistry 1996;271(30):17761-70.
1996: C Mora; J Chillarón; M J Calonge; J Forgo; Xavier Testar; Virginia Nunes; Heini Murer; Antonio Zorzano; Manuel Palacín
The rBAT gene is responsible for L-cystine uptake via the b0,(+)-like amino acid transport system in a "renal proximal tubular" cell line (OK cells).
The Journal of biological chemistry 1996;271(18):10569-76.
1996: P Muñoz; S Mora; L Sevilla; Perla Kaliman; E Tomàs; Anna Gumà; Xavier Testar; Manuel Palacín; Antonio Zorzano
Expression and insulin-regulated distribution of caveolin in skeletal muscle. Caveolin does not colocalize with GLUT4 in intracellular membranes.
The Journal of biological chemistry 1996;271(14):8133-9.
1996: Antonio Zorzano; P Muñoz; Marta Camps; C Mora; Xavier Testar; Manuel Palacín
Insulin-induced redistribution of GLUT4 glucose carriers in the muscle fiber. In search of GLUT4 trafficking pathways.
Diabetes 1996;45 Suppl 1():S70-81.
1995: Perla Kaliman; Francesc Viñals; Xavier Testar; Manuel Palacín; Antonio Zorzano
Disruption of GLUT1 glucose carrier trafficking in L6E9 and Sol8 myoblasts by the phosphatidylinositol 3-kinase inhibitor wortmannin.
The Biochemical journal 1995;312 ( Pt 2)():471-7.
1995: P Muñoz; M Rosemblatt; Xavier Testar; Manuel Palacín; G Thoidis; Paul F Pilch; Antonio Zorzano
The T-tubule is a cell-surface target for insulin-regulated recycling of membrane proteins in skeletal muscle.
The Biochemical journal 1995;312 ( Pt 2)():393-400.
1995: M J Calonge; V Volpini; Luigi Bisceglia; F Rousaud; Luisa de Sanctis; E Beccia; Leopoldo Zelante; Xavier Testar; Antonio Zorzano; Xavier Estivill
Genetic heterogeneity in cystinuria: the SLC3A1 gene is linked to type I but not to type III cystinuria.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9667-71.
1995: S Mora; Perla Kaliman; J Chillarón; Xavier Testar; Manuel Palacín; Antonio Zorzano
Insulin and insulin-like growth factor I (IGF-I) stimulate GLUT4 glucose transporter translocation in Xenopus oocytes.
The Biochemical journal 1995;311 ( Pt 1)():59-65.
1995: A Castelló; A Gumá; L Sevilla; M Furriols; Xavier Testar; Manuel Palacín; Antonio Zorzano
Regulation of GLUT5 gene expression in rat intestinal mucosa: regional distribution, circadian rhythm, perinatal development and effect of diabetes.
The Biochemical journal 1995;309 ( Pt 1)():271-7.
1995: M J Calonge; marga nadal; S Calvano; Xavier Testar; Leopoldo Zelante; Antonio Zorzano; Xavier Estivill; Paolo Gasparini; Manuel Palacín; Virginia Nunes
Assignment of the gene responsible for cystinuria (rBAT) and of markers D2S119 and D2S177 to 2p16 by fluorescence in situ hybridization.
Human genetics 1995;95(6):633-6.
1995: P Muñoz; M Rosemblatt; Xavier Testar; Manuel Palacín; Antonio Zorzano
Isolation and characterization of distinct domains of sarcolemma and T-tubules from rat skeletal muscle.
The Biochemical journal 1995;307 ( Pt 1)():273-80.
1994: A Castelló; J C Rodríguez-Manzaneque; Marta Camps; A Pérez-Castillo; Xavier Testar; Manuel Palacín; Angel Santos; Antonio Zorzano
Perinatal hypothyroidism impairs the normal transition of GLUT4 and GLUT1 glucose transporters from fetal to neonatal levels in heart and brown adipose tissue. Evidence for tissue-specific regulation of GLUT4 expression by thyroid hormone.
The Journal of biological chemistry 1994;269(8):5905-12.
1994: Marta Camps; S Vilaro; Xavier Testar; Manuel Palacín; Antonio Zorzano
High and polarized expression of GLUT1 glucose transporters in epithelial cells from mammary gland: acute down-regulation of GLUT1 carriers by weaning.
Endocrinology 1994;134(2):924-34.
1993: M Furriols; J Chillarón; C Mora; A Castelló; J Bertran; Marta Camps; Xavier Testar; Senén Vilaró; Antonio Zorzano; Manuel Palacín
rBAT, related to L-cysteine transport, is localized to the microvilli of proximal straight tubules, and its expression is regulated in kidney by development.
The Journal of biological chemistry 1993;268(36):27060-8.
1993: Christian Carpéné; E Chalaux; M Lizarbe; A Estrada; C Mora; M Palacin; Antonio Zorzano; Max Lafontan; Xavier Testar
Beta 3-adrenergic receptors are responsible for the adrenergic inhibition of insulin-stimulated glucose transport in rat adipocytes.
The Biochemical journal 1993;296 ( Pt 1)():99-105.
1993: A Castelló; Joan Cadefau; Roser Cussó; Xavier Testar; J E Hesketh; Manuel Palacín; Antonio Zorzano
GLUT-4 and GLUT-1 glucose transporter expression is differentially regulated by contractile activity in skeletal muscle.
The Journal of biological chemistry 1993;268(20):14998-5003.
1993: J Bertran; Andreas Werner; J Chillarón; Virginia Nunes; Jürg Biber; Xavier Testar; Antonio Zorzano; Xavier Estivill; Heini Murer; Manuel Palacín
Expression cloning of a human renal cDNA that induces high affinity transport of L-cystine shared with dibasic amino acids in Xenopus oocytes.
The Journal of biological chemistry 1993;268(20):14842-9.
1993: Francesc Viñals; Xavier Testar; Manuel Palacín; Antonio Zorzano
Inhibitory effect of fluoride on insulin receptor autophosphorylation and tyrosine kinase activity.
The Biochemical journal 1993;291 ( Pt 2)():615-22.
1993: Anna Gumà; Francesc Viñals; Xavier Testar; Manuel Palacín; Antonio Zorzano
Regulation of System A amino-acid transport activity by phospholipase C and cAMP-inducing agents in skeletal muscle: modulation of insulin action.
Biochimica et biophysica acta 1993;1176(1-2):155-61.
1993: Anna Gumà; Francesc Viñals; Marta Camps; M Lizarbe; C Mora; J Bertran; Xavier Testar; Manuel Palacín; Antonio Zorzano
Effect of benzyl succinate on insulin receptor function and insulin action in skeletal muscle: further evidence for a lack of spare high-affinity insulin receptors.
Molecular and cellular endocrinology 1993;91(1-2):29-33.
1992: Anna Gumà; P Muñoz; Marta Camps; Xavier Testar; Manuel Palacín; Antonio Zorzano
Inhibitors such as staurosporine, H-7 or polymyxin B cannot be used in skeletal muscle to prove the role of protein kinase C on insulin action.
Bioscience reports 1992;12(5):413-24.
1992: Anna Gumà; C Mora; Tomàs Santalucía; Francesc Viñals; Xavier Testar; Manuel Palacín; Antonio Zorzano
System A transport activity is stimulated in skeletal muscle in response to diabetes.
FEBS letters 1992;310(1):51-4.
1992: Marta Camps; Anna Gumà; Francesc Viñals; Xavier Testar; Manuel Palacín; Antonio Zorzano
Evidence for the lack of spare high-affinity insulin receptors in skeletal muscle.
The Biochemical journal 1992;285 ( Pt 3)():993-9.
1992: J Bertran; S Magagnin; Andreas Werner; Daniel Markovich; Jürg Biber; Xavier Testar; Antonio Zorzano; Lukas C Kühn; M Palacin; Heini Murer
Stimulation of system y(+)-like amino acid transport by the heavy chain of human 4F2 surface antigen in Xenopus laevis oocytes.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(12):5606-10.
1992: J Bertran; Andreas Werner; M L Moore; Gerti Stange; Daniel Markovich; Jürg Biber; Xavier Testar; Antonio Zorzano; M Palacin; Heini Murer
Expression cloning of a cDNA from rabbit kidney cortex that induces a single transport system for cystine and dibasic and neutral amino acids.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(12):5601-5.
1992: P Muñoz; Anna Gumà; Marta Camps; M Furriols; Xavier Testar; Manuel Palacín; Antonio Zorzano
Vanadate stimulates system A amino acid transport activity in skeletal muscle. Evidence for the involvement of intracellular pH as a mediator of vanadate action.
The Journal of biological chemistry 1992;267(15):10381-8.
1992: Marta Camps; A Castelló; P Muñoz; M Monfar; Xavier Testar; Manuel Palacín; Antonio Zorzano
Effect of diabetes and fasting on GLUT-4 (muscle/fat) glucose-transporter expression in insulin-sensitive tissues. Heterogeneous response in heart, red and white muscle.
The Biochemical journal 1992;282 ( Pt 3)():765-72.
1992: J Bertran; Andreas Werner; Gerti Stange; Daniel Markovich; Jürg Biber; Xavier Testar; Antonio Zorzano; M Palacin; Heini Murer
Expression of Na(+)-independent amino acid transport in Xenopus laevis oocytes by injection of rabbit kidney cortex mRNA.
The Biochemical journal 1992;281 ( Pt 3)():717-23.
1992: Tomàs Santalucía; Marta Camps; A Castelló; P Muñoz; A Nuel; Xavier Testar; M Palacin; Antonio Zorzano
Developmental regulation of GLUT-1 (erythroid/Hep G2) and GLUT-4 (muscle/fat) glucose transporter expression in rat heart, skeletal muscle, and brown adipose tissue.
Endocrinology 1992;130(2):837-46.
1992: Anna Gumà; A Castelló; Xavier Testar; Manuel Palacín; Antonio Zorzano
Differential sensitivity of insulin- and adaptive-regulation-induced system A activation to microtubular function in skeletal muscle.
The Biochemical journal 1992;281 ( Pt 2)():407-11.
1991: J Bertran; A Roca; E Pola; Xavier Testar; Antonio Zorzano; Manuel Palacín
Modification of system A amino acid carrier by diethyl pyrocarbonate.
The Journal of biological chemistry 1991;266(2):798-802.
1990: Marta Camps; Anna Gumà; Xavier Testar; Manuel Palacín; Antonio Zorzano
Insulin resistance of skeletal muscle during pregnancy is not a consequence of intrinsic modifications of insulin receptor binding or kinase activities.
Endocrinology 1990;127(5):2561-70.
1990: E Pola; J Bertran; A Roca; Manuel Palacín; Antonio Zorzano; Xavier Testar
Sensitivity of system A and ASC transport activities to thiol-group-modifying reagents in rat liver plasma-membrane vesicles. Evidence for a direct binding of N-ethylmaleimide and iodoacetamide on A and ASC carriers.
The Biochemical journal 1990;271(2):297-303.
1990: Anna Gumà; Marta Camps; Manuel Palacín; Xavier Testar; Antonio Zorzano
Protein kinase C activators selectively inhibit insulin-stimulated system A transport activity in skeletal muscle at a post-receptor level.
The Biochemical journal 1990;268(3):633-9.
1990: Antonio Zorzano; E Herrera
Differences in the kinetic properties and sensitivity to inhibitors of human placental, erythrocyte, and major hepatic aldehyde dehydrogenase isoenzymes.
Biochemical pharmacology 1990;39(5):873-8.
1990: Antonio Zorzano; E Herrera
In vivo ethanol elimination in man, monkey and rat: a lack of relationship between the ethanol metabolism and the hepatic activities of alcohol and aldehyde dehydrogenases.
Life sciences 1990;46(3):223-30.
1990: Antonio Zorzano; E Herrera
Differences in kinetic characteristics and in sensitivity to inhibitors between human and rat liver alcohol dehydrogenase and aldehyde dehydrogenase.
General pharmacology 1990;21(5):697-702.
1989: Senén Vilaró; Manuel Palacín; Paul F Pilch; Xavier Testar; Antonio Zorzano
Expression of an insulin-regulatable glucose carrier in muscle and fat endothelial cells.
Nature 1989;342(6251):798-800.
1989: Antonio Zorzano; W Wilkinson; N Kotliar; G Thoidis; B E Wadzinkski; A E Ruoho; Paul F Pilch
Insulin-regulated glucose uptake in rat adipocytes is mediated by two transporter isoforms present in at least two vesicle populations.
The Journal of biological chemistry 1989;264(21):12358-63.
1989: Antonio Zorzano; M Soley; E Herrera
Rapid effects of insulin and glucose on the hepatic incorporation of gluconeogenic substrates into glyceride glycerol and glycogen.
The International journal of biochemistry 1989;21(9):1071-5.
1988: Antonio Zorzano; E Herrera
Pregnancy and pentobarbital anaesthesia modify hepatic synthesis of acylglycerol glycerol and glycogen from gluconeogenic precursors during fasting in rats.
The Biochemical journal 1988;256(2):487-91.
1988: Anna Gumà; Xavier Testar; Manuel Palacín; Antonio Zorzano
Insulin-stimulated alpha-(methyl)aminoisobutyric acid uptake in skeletal muscle. Evidence for a short-term activation of uptake independent of Na+ electrochemical gradient and protein synthesis.
The Biochemical journal 1988;253(3):625-9.
1988: Antonio Zorzano; D E James; N B Ruderman; Paul F Pilch
Insulin-like growth factor I binding and receptor kinase in red and white muscle.
FEBS letters 1988;234(2):257-62.