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Matthew Brown

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Mark E Flanagan; Todd A Blumenkopf; William H Brissette; Matthew F Brown; Jeffrey M Casavant; Chang Shang-Poa; Jonathan L Doty; Eileen A Elliott; Michael B Fisher; Michael Hines; Craig Kent; Elizabeth M Kudlacz; Brett M Lillie; Kelly S Magnuson; Sandra P McCurdy; Michael J Munchhof; Bret Daren Perry; Perry S Sawyer; Timothy J Strelevitz; Chakrapani Subramanyam; Jianmin Sun; David A Whipple; Paul S Changelian
Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection.
Amy S Antipas; Laura C Blumberg; William H Brissette; Matthew F Brown; Jeffrey M Casavant; Jonathan L Doty; James Driscoll; Thomas M Harris; Christopher S Jones; Sandra P McCurdy; Eric McElroy; Mark Mitton-Fry; Michael J Munchhof; David A Reim; Lawrence A Reiter; Sharon L Ripp; Andrei Shavnya; Marc I Smeets; Kristen A Trevena
Structure-activity relationships and hepatic safety risks of thiazole agonists of the thrombopoietin receptor.
Michael J Munchhof; Amy S Antipas; Laura C Blumberg; William H Brissette; Matthew F Brown; Jeffrey M Casavant; Jonathan L Doty; James P Driscoll; Thomas M Harris; Lilli A Wolf-Gouveia; Christopher S Jones; Qifang Li; Robert G Linde; Paul D Lira; Anthony Marfat; Eric McElroy; Mark Mitton-Fry; Sandra P McCurdy; Lawrence A Reiter; Sharon L Ripp; Andrei Shavnya; Lisa M Thomasco; Kristen A Trevena
The identification of orally bioavailable thrombopoietin agonists.

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2010: Mark E Flanagan; Todd A Blumenkopf; William H Brissette; Matthew F Brown; Jeffrey M Casavant; Chang Shang-Poa; Jonathan L Doty; Eileen A Elliott; Michael B Fisher; Michael Hines; Craig Kent; Elizabeth M Kudlacz; Brett M Lillie; Kelly S Magnuson; Sandra P McCurdy; Michael J Munchhof; Bret Daren Perry; Perry S Sawyer; Timothy J Strelevitz; Chakrapani Subramanyam; Jianmin Sun; David A Whipple; Paul S Changelian
Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection.
Journal of medicinal chemistry 2010;53(24):8468-84.
2010: Amy S Antipas; Laura C Blumberg; William H Brissette; Matthew F Brown; Jeffrey M Casavant; Jonathan L Doty; James Driscoll; Thomas M Harris; Christopher S Jones; Sandra P McCurdy; Eric McElroy; Mark Mitton-Fry; Michael J Munchhof; David A Reim; Lawrence A Reiter; Sharon L Ripp; Andrei Shavnya; Marc I Smeets; Kristen A Trevena
Structure-activity relationships and hepatic safety risks of thiazole agonists of the thrombopoietin receptor.
Bioorganic & medicinal chemistry letters 2010;20(14):4069-72.
2009: Michael J Munchhof; Amy S Antipas; Laura C Blumberg; William H Brissette; Matthew F Brown; Jeffrey M Casavant; Jonathan L Doty; James P Driscoll; Thomas M Harris; Lilli A Wolf-Gouveia; Christopher S Jones; Qifang Li; Robert G Linde; Paul D Lira; Anthony Marfat; Eric McElroy; Mark Mitton-Fry; Sandra P McCurdy; Lawrence A Reiter; Sharon L Ripp; Andrei Shavnya; Lisa M Thomasco; Kristen A Trevena
The identification of orally bioavailable thrombopoietin agonists.
Bioorganic & medicinal chemistry letters 2009;19(5):1428-30.
2007: Matthew F Brown; Kevin Bahnck; Laura C Blumberg; William H Brissette; Sara A Burrell; James P Driscoll; Flavia Fedeles; Michael B Fisher; Robert S Foti; Ronald P Gladue; Aikomari Guzman-Martinez; Matthew M Hayward; Paul D Lira; Brett M Lillie; Yi Lu; Greg D Lundquist; Eric B McElroy; Molly A McGlynn; Timothy J Paradis; Christopher S Poss; James H Roache; Andrei Shavnya; Richard M Shepard; Kristen A Trevena; Laurie A Tylaska
Piperazinyl CCR1 antagonists--optimization of human liver microsome stability.
Bioorganic & medicinal chemistry letters 2007;17(11):3109-12.
2004: Matthew F Brown; Mike Avery; William H Brissette; J H Chang; Kevin Colizza; Maryrose Conklyn; Amy P DiRico; Ronald P Gladue; John C Kath; Suzanne S Krueger; Paul D Lira; Brett M Lillie; Greg D Lundquist; Erin N Mairs; Eric B McElroy; Molly A McGlynn; Timothy J Paradis; Christopher S Poss; Michelle I Rossulek; Richard M Shepard; Jeff Sims; Timothy J Strelevitz; Susan Truesdell; Laurie A Tylaska; Kwansik Yoon; Deye Zheng
Novel CCR1 antagonists with improved metabolic stability.
Bioorganic & medicinal chemistry letters 2004;14(9):2175-9.
2004: John C Kath; William H Brissette; Matthew F Brown; Maryrose Conklyn; Amy P DiRico; Peter Dorff; Ronald P Gladue; Brett M Lillie; Paul D Lira; Erin N Mairs; William Martin; Eric B McElroy; Molly A McGlynn; Timothy J Paradis; Christopher S Poss; Ingrid A Stock; Laurie A Tylaska; Deye Zheng
Potent small molecule CCR1 antagonists.
Bioorganic & medicinal chemistry letters 2004;14(9):2169-73.
2004: Ronald P Gladue; Samuel H Zwillich; Alan T Clucas; Matthew F Brown
CCR1 antagonists for the treatment of autoimmune diseases.
Current opinion in investigational drugs (London, England : 2000) 2004;5(5):499-504.
2003: Ronald P Gladue; Laurie A Tylaska; William H Brissette; Paul D Lira; John C Kath; Christopher S Poss; Matthew F Brown; Timothy J Paradis; Maryrose Conklyn; Kevin Ogborne; Molly A McGlynn; Brett M Lillie; Amy P DiRico; Erin N Mairs; Eric B McElroy; William Martin; Ingrid A Stock; Richard M Shepard; Henry J Showell; Kuldeep S Neote
CP-481,715, a potent and selective CCR1 antagonist with potential therapeutic implications for inflammatory diseases.
The Journal of biological chemistry 2003;278(42):40473-80.
1998: Matthew F Brown; Anthony Marfat; GW Antognoli; Robert J Chambers; John B Cheng; D B Damon; T E Liston; Molly A McGlynn; S P O'Sullivan; B S Owens; JS Pillar; John T Shirley; John W Watson
N-carbamoyl analogs of Zafirlukast: potent receptor antagonists of leukotriene D4.
Bioorganic & medicinal chemistry letters 1998;8(18):2451-6.