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Marion Brown

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Robin Mihrshahi; Marion H Brown
Downstream of tyrosine kinase 1 and 2 play opposing roles in CD200 receptor signaling.
Marion H Brown; Erica Lacey
A ligand for CD5 is CD5.
Kate M Peters; George Sharbeen; Torsten Theis; Ronald A Skurray; Marion H Brown
Biochemical characterization of the multidrug regulator QacR distinguishes residues that are crucial to multidrug binding and induction of qacA transcription.

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All Publications

2010: Robin Mihrshahi; Marion H Brown
Downstream of tyrosine kinase 1 and 2 play opposing roles in CD200 receptor signaling.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(12):7216-22.
2010: Marion H Brown; Erica Lacey
A ligand for CD5 is CD5.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(10):6068-74.
2009: Kate M Peters; George Sharbeen; Torsten Theis; Ronald A Skurray; Marion H Brown
Biochemical characterization of the multidrug regulator QacR distinguishes residues that are crucial to multidrug binding and induction of qacA transcription.
Biochemistry 2009;48(41):9794-800.
2009: Robin Mihrshahi; A Neil Barclay; Marion H Brown
Essential roles for Dok2 and RasGAP in CD200 receptor-mediated regulation of human myeloid cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(8):4879-86.
2009: Nicholas G Clarkson; Marion H Brown
Inhibition and activation by CD244 depends on CD2 and phospholipase C-gamma1.
The Journal of biological chemistry 2009;284(37):24725-34.
2008: Kate M Peters; Jason T Schuman; Ronald A Skurray; Marion H Brown; Richard G Brennan; Maria A Schumacher
QacR-cation recognition is mediated by a redundancy of residues capable of charge neutralization.
Biochemistry 2008;47(31):8122-9.
2007: Karl A Hassan; Ronald A Skurray; Marion H Brown
Transmembrane helix 12 of the Staphylococcus aureus multidrug transporter QacA lines the bivalent cationic drug binding pocket.
Journal of bacteriology 2007;189(24):9131-4.
2007: Nicholas G Clarkson; Stephen J Simmonds; Michael J Puklavec; Marion H Brown
Direct and indirect interactions of the cytoplasmic region of CD244 (2B4) in mice and humans with FYN kinase.
The Journal of biological chemistry 2007;282(35):25385-94.
2007: Torsten Theis; Ronald A Skurray; Marion H Brown
Identification of suitable internal controls to study expression of a Staphylococcus aureus multidrug resistance system by quantitative real-time PCR.
Journal of microbiological methods 2007;70(2):355-62.
2007: Karl A Hassan; Ronald A Skurray; Marion H Brown
Active export proteins mediating drug resistance in staphylococci.
Journal of molecular microbiology and biotechnology 2007;12(3-4):180-96.
2006: Karl A Hassan; Katie L Robinson; Alison N Smith; Joanne H Gibson; Ronald A Skurray; Marion H Brown
Glycine-rich transmembrane helix 10 in the staphylococcal tetracycline transporter TetA(K) lines a solvent-accessible channel.
Biochemistry 2006;45(51):15661-9.
2006: Karl A Hassan; Melanie Galea; Jingqin Wu; Bernadette A Mitchell; Ronald A Skurray; Marion H Brown
Functional effects of intramembranous proline substitutions in the staphylococcal multidrug transporter QacA.
FEMS microbiology letters 2006;263(1):76-85.
2006: Namir J Hassan; Stephen J Simmonds; Nicholas G Clarkson; Sarah Hanrahan; Michael J Puklavec; Martine Bomb; A Neil Barclay; Marion H Brown
CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76.
Molecular and cellular biology 2006;26(17):6727-38.
2006: Massoud Saidijam; Giulia Benedetti; Qinghu Ren; Zhiqiang Xu; Christopher J Hoyle; Sarah L Palmer; Alison Ward; Kim E Bettaney; Gerda Szakonyi; Johan Meuller; Scott Morrison; Martin K Pos; Patrick Butaye; Karl Walravens; Kate Langton; Richard B Herbert; Ronald A Skurray; Ian Paulsen; John O'Reilly; Nicholas G Rutherford; Marion H Brown; Roslyn M Bill; Peter J F Henderson
Microbial drug efflux proteins of the major facilitator superfamily.
Current drug targets 2006;7(7):793-811.
2006: Arnold S Bayer; Leon Iri Kupferwasser; Marion H Brown; Ronald A Skurray; Steve Grkovic; T Jones; K Mukhopadhay; Michael Yeaman
Low-level resistance of Staphylococcus aureus to thrombin-induced platelet microbicidal protein 1 in vitro associated with qacA gene carriage is independent of multidrug efflux pump activity.
Antimicrobial agents and chemotherapy 2006;50(7):2448-54.
2006: A Neil Barclay; Marion H Brown
The SIRP family of receptors and immune regulation.
Nature reviews. Immunology 2006;6(6):457-64.
2006: Zhiqiang Xu; Brendon A O'Rourke; Ronald A Skurray; Marion H Brown
Role of transmembrane segment 10 in efflux mediated by the staphylococcal multidrug transport protein QacA.
The Journal of biological chemistry 2006;281(2):792-9.
2005: Kaushik Choudhuri; David Wiseman; Marion H Brown; Keith Gould; Philip van der Merwe
T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand.
Nature 2005;436(7050):578-82.
2005: Despina Voulgaraki; Rita Mitnacht-Kraus; Michelle Letarte; Mildred Foster-Cuevas; Marion H Brown; A Neil Barclay
Multivalent recombinant proteins for probing functions of leucocyte surface proteins such as the CD200 receptor.
Immunology 2005;115(3):337-46.
2004: Gary Brooke; Joanna D Holbrook; Marion H Brown; A Neil Barclay
Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(4):2562-70.
2004: Mildred Foster-Cuevas; Gavin J Wright; Michael J Puklavec; Marion H Brown; A Neil Barclay
Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor.
Journal of virology 2004;78(14):7667-76.
2004: Namir J Hassan; A Neil Barclay; Marion H Brown
Frontline: Optimal T cell activation requires the engagement of CD6 and CD166.
European journal of immunology 2004;34(4):930-40.
2003: Steve Grkovic; Kate M Hardie; Marion H Brown; Ronald A Skurray
Interactions of the QacR multidrug-binding protein with structurally diverse ligands: implications for the evolution of the binding pocket.
Biochemistry 2003;42(51):15226-36.
2003: S Melanie Hanna; Peter Kirk; Oliver J Holt; Michael J Puklavec; Marion H Brown; A Neil Barclay
A novel form of the membrane protein CD147 that contains an extra Ig-like domain and interacts homophilically.
BMC biochemistry 2003;4():17.
2003: Gavin J Wright; Holly Cherwinski; Mildred Foster-Cuevas; Gary Brooke; Michael J Puklavec; Mike E Bigler; Yaoli Song; Maria C Jenmalm; Daniel Gorman; Terrill McClanahan; Man-Ru Liu; Marion H Brown; Jonathon D Sedgwick; Joseph H Phillips; A Neil Barclay
Characterization of the CD200 receptor family in mice and humans and their interactions with CD200.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(6):3034-46.
2003: Nicholas Hutchings; Nicholas G Clarkson; Robert Chalkley; A Neil Barclay; Marion H Brown
Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85.
The Journal of biological chemistry 2003;278(25):22396-403.
2003: Steve Grkovic; Marion H Brown; Kate M Hardie; Neville Firth; Ronald A Skurray
Stable low-copy-number Staphylococcus aureus shuttle vectors.
Microbiology (Reading, England) 2003;149(Pt 3):785-94.
2002: Steve Grkovic; Marion H Brown; Ronald A Skurray
Regulation of bacterial drug export systems.
Microbiology and molecular biology reviews : MMBR 2002;66(4):671-701, table of contents.
2002: A Neil Barclay; Gavin J Wright; Gary Brooke; Marion H Brown
CD200 and membrane protein interactions in the control of myeloid cells.
Trends in immunology 2002;23(6):285-90.
2002: Marion H Brown
Detection of low-affinity ligand-receptor interactions at the cell surface with fluorescent microspheres.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2002;Chapter 18():Unit 18.2.
2002: Maria A Schumacher; Marshall C Miller; Steve Grkovic; Marion H Brown; Ronald A Skurray; Richard G Brennan
Structural basis for cooperative DNA binding by two dimers of the multidrug-binding protein QacR.
The EMBO journal 2002;21(5):1210-8.
2001: Maria A Schumacher; Marshall C Miller; Steve Grkovic; Marion H Brown; Ronald A Skurray; Richard G Brennan
Structural mechanisms of QacR induction and multidrug recognition.
Science (New York, N.Y.) 2001;294(5549):2158-63.
2001: Steve Grkovic; Marion H Brown; Maria A Schumacher; Richard G Brennan; Ronald A Skurray
The staphylococcal QacR multidrug regulator binds a correctly spaced operator as a pair of dimers.
Journal of bacteriology 2001;183(24):7102-9.
2001: Steve Grkovic; Marion H Brown; Ronald A Skurray
Transcriptional regulation of multidrug efflux pumps in bacteria.
Seminars in cell & developmental biology 2001;12(3):225-37.
2001: Marion H Brown; Ronald A Skurray
Staphylococcal multidrug efflux protein QacA.
Journal of molecular microbiology and biotechnology 2001;3(2):163-70.
2001: Gavin J Wright; M Jones; Michael J Puklavec; Marion H Brown; A Neil Barclay
The unusual distribution of the neuronal/lymphoid cell surface CD200 (OX2) glycoprotein is conserved in humans.
Immunology 2001;102(2):173-9.
2000: Robert M Hoek; Sigrid Ruuls; Craig Murphy; Gavin J Wright; R Goddard; Sandra Zurawski; B Blom; M E Homola; W J Streit; Marion H Brown; A Neil Barclay; Jonathon D Sedgwick
Down-regulation of the macrophage lineage through interaction with OX2 (CD200).
Science (New York, N.Y.) 2000;290(5497):1768-71.
2000: Nasim Mavaddat; D W Mason; P D Atkinson; Edward J Evans; Robert J C Gilbert; David I Stuart; Janet A Fennelly; A Neil Barclay; Simon J Davis; Marion H Brown
Signaling lymphocytic activation molecule (CDw150) is homophilic but self-associates with very low affinity.
The Journal of biological chemistry 2000;275(36):28100-9.
2000: Gavin J Wright; Michael J Puklavec; A C Willis; Robert M Hoek; Jonathon D Sedgwick; Marion H Brown; A Neil Barclay
Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function.
Immunity 2000;13(2):233-42.
2000: Elizabeth Vernon-Wilson; W J Kee; A C Willis; A N Barclay; D L Simmons; Marion H Brown
CD47 is a ligand for rat macrophage membrane signal regulatory protein SIRP (OX41) and human SIRPalpha 1.
European journal of immunology 2000;30(8):2130-7.
2000: P Kirk; Marieangela C Wilson; Catherine Heddle; Marion H Brown; A Neil Barclay; Andrew P Halestrap
CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression.
The EMBO journal 2000;19(15):3896-904.
2000: Arnold S Bayer; R Prasad; J Chandra; A Koul; M Smriti; A Varma; Ronald A Skurray; Neville Firth; Marion H Brown; SP Koo; Michael Yeaman
In vitro resistance of Staphylococcus aureus to thrombin-induced platelet microbicidal protein is associated with alterations in cytoplasmic membrane fluidity.
Infection and immunity 2000;68(6):3548-53.
2000: Suyin Ginn; Marion H Brown; Ronald A Skurray
The TetA(K) tetracycline/H(+) antiporter from Staphylococcus aureus: mutagenesis and functional analysis of motif C.
Journal of bacteriology 2000;182(6):1492-8.
1999: Leon Iri Kupferwasser; Ronald A Skurray; Marion H Brown; Neville Firth; Michael Yeaman; Arnold S Bayer
Plasmid-mediated resistance to thrombin-induced platelet microbicidal protein in staphylococci: role of the qacA locus.
Antimicrobial agents and chemotherapy 1999;43(10):2395-9.
1999: M K Wild; A Cambiaggi; Marion H Brown; Elizabeth A Davies; H Ohno; Takashi Saito; Philip van der Merwe
Dependence of T cell antigen recognition on the dimensions of an accessory receptor-ligand complex.
The Journal of experimental medicine 1999;190(1):31-41.
1999: Pauline M Rudd; Mark R Wormald; David Harvey; M Devasahayam; Mark S B McAlister; Marion H Brown; Simon J Davis; A Neil Barclay; Raymond A Dwek
Oligosaccharide analysis and molecular modeling of soluble forms of glycoproteins belonging to the Ly-6, scavenger receptor, and immunoglobulin superfamilies expressed in Chinese hamster ovary cells.
Glycobiology 1999;9(5):443-58.
1999: Bernadette A Mitchell; Ian Paulsen; Marion H Brown; Ronald A Skurray
Bioenergetics of the staphylococcal multidrug export protein QacA. Identification of distinct binding sites for monovalent and divalent cations.
The Journal of biological chemistry 1999;274(6):3541-8.
1999: Marion H Brown; Ian Paulsen; Ronald A Skurray
The multidrug efflux protein NorM is a prototype of a new family of transporters.
Molecular microbiology 1999;31(1):394-5.
1998: Marion H Brown; Kent S Boles; Philip van der Merwe; Vinay Kumar; P A Mathew; A N Barclay
2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48.
The Journal of experimental medicine 1998;188(11):2083-90.
1998: Mark S B McAlister; Marion H Brown; A C Willis; Pauline M Rudd; David Harvey; R Aplin; DM Shotton; Raymond A Dwek; A Neil Barclay; Paul C Driscoll
Structural analysis of the CD5 antigen--expression, disulphide bond analysis and physical characterisation of CD5 scavenger receptor superfamily domain 1.
European journal of biochemistry / FEBS 1998;257(1):131-41.
1998: Steve Grkovic; Marion H Brown; N J Roberts; Ian Paulsen; Ronald A Skurray
QacR is a repressor protein that regulates expression of the Staphylococcus aureus multidrug efflux pump QacA.
The Journal of biological chemistry 1998;273(29):18665-73.
1998: Ian Paulsen; Marion H Brown; Ronald A Skurray
Characterization of the earliest known Staphylococcus aureus plasmid encoding a multidrug efflux system.
Journal of bacteriology 1998;180(13):3477-9.
1998: Bernadette A Mitchell; Marion H Brown; Ronald A Skurray
QacA multidrug efflux pump from Staphylococcus aureus: comparative analysis of resistance to diamidines, biguanidines, and guanylhydrazones.
Antimicrobial agents and chemotherapy 1998;42(2):475-7.
1997: S Preston; Gavin J Wright; K Starr; A Neil Barclay; Marion H Brown
The leukocyte/neuron cell surface antigen OX2 binds to a ligand on macrophages.
European journal of immunology 1997;27(8):1911-8.
1997: Suyin Ginn; Marion H Brown; Ronald A Skurray
Membrane topology of the metal-tetracycline/H+ antiporter TetA(K) from Staphylococcus aureus.
Journal of bacteriology 1997;179(11):3786-9.
1997: A Al-Shamkhani; S Mallett; Marion H Brown; William James; A Neil Barclay
Affinity and kinetics of the interaction between soluble trimeric OX40 ligand, a member of the tumor necrosis factor superfamily, and its receptor OX40 on activated T cells.
The Journal of biological chemistry 1997;272(8):5275-82.
1997: A N Barclay; Marion H Brown
Heterogeneity of interactions mediated by membrane glycoproteins of lymphocytes.
Biochemical Society transactions 1997;25(1):224-8.
1996: A Al-Shamkhani; M L Birkeland; Michael J Puklavec; Marion H Brown; William James; A Neil Barclay
OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand.
European journal of immunology 1996;26(8):1695-9.
1996: Ian Paulsen; Marion H Brown; T G Littlejohn; B A Mitchell; Ronald A Skurray
Multidrug resistance proteins QacA and QacB from Staphylococcus aureus: membrane topology and identification of residues involved in substrate specificity.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(8):3630-5.
1995: Marion H Brown; S Preston; A Neil Barclay
A sensitive assay for detecting low-affinity interactions at the cell surface reveals no additional ligands for the adhesion pair rat CD2 and CD48.
European journal of immunology 1995;25(12):3222-8.
1995: Ian Paulsen; Marion H Brown; S J Dunstan; Ronald A Skurray
Molecular characterization of the staphylococcal multidrug resistance export protein QacC.
Journal of bacteriology 1995;177(10):2827-33.
1994: Marion H Brown; A Neil Barclay
Expression of immunoglobulin and scavenger receptor superfamily domains as chimeric proteins with domains 3 and 4 of CD4 for ligand analysis.
Protein engineering 1994;7(4):515-21.
1993: Philip van der Merwe; Marion H Brown; Simon J Davis; A Neil Barclay
Affinity and kinetic analysis of the interaction of the cell adhesion molecules rat CD2 and CD48.
The EMBO journal 1993;12(13):4945-54.
1993: Philip van der Merwe; Marion H Brown; Simon J Davis; A Neil Barclay
Measuring very low affinity interactions between immunoglobulin superfamily cell-adhesion molecules.
Biochemical Society transactions 1993;21(4):340S.
1993: Philip van der Merwe; D C McPherson; Marion H Brown; A Neil Barclay; Jason G Cyster; A F Williams; Simon J Davis
The NH2-terminal domain of rat CD2 binds rat CD48 with a low affinity and binding does not require glycosylation of CD2.
European journal of immunology 1993;23(6):1373-7.