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Obbe Zuiderveld

Research Profile

Chemicals & Drugs

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Structure-Activity Relationship

Living Beings

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Muscle Contraction

Physiology

Binding, Competitive

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Radioligand Assay

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Publications

TOP 3
Sabine Schultes; Obbe P Zuiderveld; Iwan J P De Esch; Harald Engelhardt; Eric E J Haaksma; Rob Leurs; Luc Roumen; Chris de Graaf
Combining quantum mechanical ligand conformation analysis and protein modeling to elucidate GPCR-ligand binding modes.
Harald Engelhardt; Eric E J Haaksma; Daniel Kuhn; Sebastian Lips; Moriz Mayer; Dirk Scharn; Rogier A Smits; Obbe P Zuiderveld; Heribert Arnhof; Iwan J P De Esch; Julia Dobler; Rob Leurs
Detailed structure-activity relationship of indolecarboxamides as H4 receptor ligands.
Mark H P Verheij; Henry Vischer; Obbe P Zuiderveld; Chris de Graaf; Gerdien E de Kloe; Saskia Hulscher; Rob Leurs; Sarah C R Lummis; Saskia Nijmeijer; Linda Silvestri; Rogier A Smits; Andrew J Thompson; Jacqueline van Muijlwijk-Koezen; Iwan J P De Esch
Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H₄ and the ion channel serotonin 5-HT₃A.

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All Publications

2013: Sabine Schultes; Obbe P Zuiderveld; Iwan J P De Esch; Harald Engelhardt; Eric E J Haaksma; Rob Leurs; Luc Roumen; Chris de Graaf
Combining quantum mechanical ligand conformation analysis and protein modeling to elucidate GPCR-ligand binding modes.
ChemMedChem 2013;8(1):49-53.
2012: Harald Engelhardt; Eric E J Haaksma; Daniel Kuhn; Sebastian Lips; Moriz Mayer; Dirk Scharn; Rogier A Smits; Obbe P Zuiderveld; Heribert Arnhof; Iwan J P De Esch; Julia Dobler; Rob Leurs
Detailed structure-activity relationship of indolecarboxamides as H4 receptor ligands.
European journal of medicinal chemistry 2012;54():660-8.
2011: Mark H P Verheij; Henry Vischer; Obbe P Zuiderveld; Chris de Graaf; Gerdien E de Kloe; Saskia Hulscher; Rob Leurs; Sarah C R Lummis; Saskia Nijmeijer; Linda Silvestri; Rogier A Smits; Andrew J Thompson; Jacqueline van Muijlwijk-Koezen; Iwan J P De Esch
Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H₄ and the ion channel serotonin 5-HT₃A.
Bioorganic & medicinal chemistry letters 2011;21(18):5460-4.
2011: Lindsay B Hough; Julia W Nalwalk; Jun Yang; Jennie L Conroy; Melissa A VanAlstine; Weizhu Yang; Joseph Gargano; Zhixing Shan; Shao-Zhong Zhang; Mark P Wentland; James G Phillips; Brian I Knapp; Jean M Bidlack; Obbe P Zuiderveld; Rob Leurs; Xinxin Ding
Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic.
Pain 2011;152(4):878-87.
2010: Rogier A Smits; Maristella Adami; Enade P Istyastono; Obbe P Zuiderveld; Cindy M E van Dam; Frans J J de Kanter; Aldo Jongejan; Gabriella Coruzzi; Rob Leurs; Iwan J P De Esch
Synthesis and QSAR of quinazoline sulfonamides as highly potent human histamine H4 receptor inverse agonists.
Journal of medicinal chemistry 2010;53(6):2390-400.
2010: Jennie L Conroy; Cheng Fang; Jun Gu; Scott O Zeitlin; Weizhu Yang; Jun Yang; Melissa A VanAlstine; Julia W Nalwalk; Phillip J Albrecht; Joseph E Mazurkiewicz; Abigail Snyder-Keller; Zhixing Shan; Shao-Zhong Zhang; Mark P Wentland; Melissa Behr; Brian I Knapp; Jean M Bidlack; Obbe P Zuiderveld; Rob Leurs; Xinxin Ding; Lindsay B Hough
Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling.
Nature neuroscience 2010;13(3):284-6.
2009: Herman D Lim; Enade P Istyastono; Andrea van de Stolpe; Giuseppe Romeo; Silvia Gobbi; Marjo Schepers; Roger Lahaye; Wiro M P B Menge; Obbe P Zuiderveld; Aldo Jongejan; Rogier A Smits; Remko A Bakker; Eric E J Haaksma; Rob Leurs; Iwan J P De Esch
Clobenpropit analogs as dual activity ligands for the histamine H3 and H4 receptors: synthesis, pharmacological evaluation, and cross-target QSAR studies.
Bioorganic & medicinal chemistry 2009;17(11):3987-94.
2008: Iwona Maslowska-Lipowicz; Marek Figlus; Obbe P Zuiderveld; Krzysztof Walczynski
New 1-benzyl-4-hydroxypiperidine derivatives as non-imidazole histamine H3 receptor antagonists.
Archiv der Pharmazie 2008;341(12):762-73.
2008: Richard M van Rijn; André van Marle; Paul L Chazot; Ellen Langemeijer; Yongjun Qin; Fiona C Shenton; Herman D Lim; Obbe P Zuiderveld; Kamonchanok Sansuk; Michel Dy; Martine J Smit; Cornelis P Tensen; Remko A Bakker; Rob Leurs
Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor.
The Biochemical journal 2008;414(1):121-31.
2008: Rogier A Smits; Herman D Lim; Agnes Hanzer; Obbe P Zuiderveld; Elena Guaita; Maristella Adami; Gabriella Coruzzi; Rob Leurs; Iwan J P De Esch
Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo.
Journal of medicinal chemistry 2008;51(8):2457-67.
2005: Ruengwit Kitbunnadaj; Takeshi Hashimoto; Enzo Poli; Obbe P Zuiderveld; Alessandro Menozzi; Ryoko Hidaka; Iwan J P De Esch; Remko A Bakker; Wiro M P B Menge; Atsushi Yamatodani; Gabriella Coruzzi; Henk Timmerman; Rob Leurs
N-substituted piperidinyl alkyl imidazoles: discovery of methimepip as a potent and selective histamine H3 receptor agonist.
Journal of medicinal chemistry 2005;48(6):2100-7.
2005: Krzysztof Walczyński; Obbe P Zuiderveld; Henk Timmerman
Non-imidazole histamine H3 ligands. Part III. New 4-n-propylpiperazines as non-imidazole histamine H3-antagonists.
European journal of medicinal chemistry 2005;40(1):15-23.
2004: Ruengwit Kitbunnadaj; Obbe P Zuiderveld; Bernard Christophe; Saskia Hulscher; Wiro M P B Menge; Edith Gelens; Erwin Snip; Remko A Bakker; Sylvain Celanire; Michel Gillard; Patrice Talaga; Henk Timmerman; Rob Leurs
Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H(3) receptor agonist.
Journal of medicinal chemistry 2004;47(10):2414-7.
2004: Remko A Bakker; David M Weiner; Antonius Marinus ter Laak; T Beuming; Obbe P Zuiderveld; M Edelbroek; Uli Hacksell; Henk Timmerman; Mark R Brann; Rob Leurs
8R-lisuride is a potent stereospecific histamine H1-receptor partial agonist.
Molecular pharmacology 2004;65(3):538-49.
2003: Ruengwit Kitbunnadaj; Obbe P Zuiderveld; Iwan J P De Esch; Roeland C Vollinga; Remko A Bakker; Martin Lutz; Anthony L Spek; Emile Cavoy; Marie-France Deltent; Wiro M P B Menge; Henk Timmerman; Rob Leurs
Synthesis and structure-activity relationships of conformationally constrained histamine H(3) receptor agonists.
Journal of medicinal chemistry 2003;46(25):5445-57.
2003: Takeshi Hashimoto; Shinya Harusawa; Lisa Araki; Obbe P Zuiderveld; Martine J Smit; Tomonari Imazu; Seiichiroh Takashima; Yumiko Yamamoto; Yasuhiko Sakamoto; Takushi Kurihara; Rob Leurs; Remko A Bakker; Atsushi Yamatodani
A selective human H(4)-receptor agonist: (-)-2-cyano-1-methyl-3-[(2R,5R)-5- [1H-imidazol-4(5)-yl]tetrahydrofuran-2-y] methylguanidine.
Journal of medicinal chemistry 2003;46(14):3162-5.
2000: K Walczyński; R Guryn; Obbe P Zuiderveld; M Q Zhang; Henk Timmerman
Histamine H1 receptor ligands: part II. Synthesis and in vitro pharmacology of 2-[2-(phenylamino)thiazol-4-yl]ethanamine and 2-(2-benzhydrylthiazol-4-yl)ethanamine derivatives.
Farmaco (Società chimica italiana : 1989) 2000;55(9-10):569-74.
1999: K Walczyński; R Guryn; Obbe P Zuiderveld; Henk Timmerman
Non-imidazole histamine H3 ligands, Part 2: New 2-substituted benzothiazoles as histamine H3 antagonists.
Archiv der Pharmazie 1999;332(11):389-98.
1999: K Walczyński; R Guryn; Obbe P Zuiderveld; Henk Timmerman
Non-imidazole histamine H3 ligands. Part I. Synthesis of 2-(1-piperazinyl)- and 2-(hexahydro-1H-1,4-diazepin-1-yl)benzothiazole derivatives as H3-antagonists with H1 blocking activities.
Farmaco (Società chimica italiana : 1989) 1999;54(10):684-94.
1999: K Walczyński; Henk Timmerman; Obbe P Zuiderveld; M Q Zhang; R Glinka
Histamine H1 receptor ligands. Part I. Novel thiazol-4-ylethanamine derivatives: synthesis and in vitro pharmacology.
Farmaco (Società chimica italiana : 1989) 1999;54(8):533-41.
1999: Iwan J P De Esch; Roeland C Vollinga; Kees Goubitz; Henk Schenk; U Appelberg; Uli Hacksell; S Lemstra; Obbe P Zuiderveld; Marcel Hoffmann; Rob Leurs; Wiro M P B Menge; Henk Timmerman
Characterization of the binding site of the histamine H3 receptor. 1. Various approaches to the synthesis of 2-(1H-imidazol-4-yl)cyclopropylamine and histaminergic activity of (1R,2R)- and (1S,2S)-2-(1H-imidazol-4-yl)-cyclopropylamine.
Journal of medicinal chemistry 1999;42(7):1115-22.
1998: A Alves-Rodrigues; Henk Timmerman; E Willems; S Lemstra; Obbe P Zuiderveld; Rob Leurs
Pharmacological characterisation of the histamine H3 receptor in the rat hippocampus.
Brain research 1998;788(1-2):179-86.
1995: R Leurs; M T Tulp; Wiro M P B Menge; M J Adolfs; Obbe P Zuiderveld; H Timmerman
Evaluation of the receptor selectivity of the H3 receptor antagonists, iodophenpropit and thioperamide: an interaction with the 5-HT3 receptor revealed.
British journal of pharmacology 1995;116(4):2315-21.
1992: R C Vollinga; Obbe P Zuiderveld; H Scheerens; Aalt Bast; H Timmerman
A simple and rapid in vitro test system for the screening of histamine H3 ligands.
Methods and findings in experimental and clinical pharmacology 1992;14(10):747-51.