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Neal Brown

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TOP 3
Marjorie H Barnes; Michelle M Butler; George E Wright; Neal C Brown
Antimicrobials targeted to the replication-specific DNA polymerases of gram-positive bacteria: target potential of dnaE.
Sofya Dvoskin; Wei-Chu Xu; Ivan B Yanachkov; Milka Yanachkova; Neal C Brown; George E Wright
A novel agent effective against Clostridium difficile infection.
Wei-Chu Xu; Chengxin Zhi; Marjorie H Barnes; Neal C Brown; Sofya Dvoskin; Joseph J Gambino; Zheng-Yu Long; George E Wright; Michelle M Butler
7-Alkyl-N(2)-substituted-3-deazaguanines. Synthesis, DNA polymerase III inhibition and antibacterial activity.

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All Publications

2012: Marjorie H Barnes; Michelle M Butler; George E Wright; Neal C Brown
Antimicrobials targeted to the replication-specific DNA polymerases of gram-positive bacteria: target potential of dnaE.
Infectious disorders drug targets 2012;12(5):327-31.
2012: Sofya Dvoskin; Wei-Chu Xu; Ivan B Yanachkov; Milka Yanachkova; Neal C Brown; George E Wright
A novel agent effective against Clostridium difficile infection.
Antimicrobial agents and chemotherapy 2012;56(3):1624-6.
2011: Wei-Chu Xu; Chengxin Zhi; Marjorie H Barnes; Neal C Brown; Sofya Dvoskin; Joseph J Gambino; Zheng-Yu Long; George E Wright; Michelle M Butler
7-Alkyl-N(2)-substituted-3-deazaguanines. Synthesis, DNA polymerase III inhibition and antibacterial activity.
Bioorganic & medicinal chemistry letters 2011;21(14):4197-202.
2007: Michelle M Butler; William A LaMarr; Kimberly A Foster; Marjorie H Barnes; Donna J Skow; Patrick T Lyden; Lauren M Kustigian; Chengxin Zhi; Neal C Brown; George E Wright; Terry L Bowlin
Antibacterial activity and mechanism of action of a novel anilinouracil-fluoroquinolone hybrid compound.
Antimicrobial agents and chemotherapy 2007;51(1):119-27.
2006: Chengxin Zhi; Zheng-Yu Long; Andrzej Manikowski; Jeanne Comstock; Wei-Chu Xu; Neal C Brown; Paul M Tarantino; Karsten A Holm; Edward J Dix; George E Wright; Marjorie H Barnes; Michelle M Butler; Kimberly A Foster; William A LaMarr; Benoit Bachand; Richard Bethell; Caroline Cadilhac; Sylvie Charron; Serge Lamothe; Irina Motorina; Richard Storer
Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors.
Journal of medicinal chemistry 2006;49(4):1455-65.
2005: Chengxin Zhi; Zheng-Yu Long; Andrzej Manikowski; Neal C Brown; Paul M Tarantino; Karsten Holm; Edward J Dix; George E Wright; Kimberly A Foster; Michelle M Butler; William A LaMarr; Donna J Skow; Irina Motorina; Serge Lamothe; Richard Storer
Synthesis and antibacterial activity of 3-substituted-6-(3-ethyl-4-methylanilino)uracils.
Journal of medicinal chemistry 2005;48(22):7063-74.
2005: George E Wright; Neal C Brown; Wei-Chu Xu; Zheng-Yu Long; Chengxin Zhi; Joseph J Gambino; Marjorie H Barnes; Michelle M Butler
Active site directed inhibitors of replication-specific bacterial DNA polymerases.
Bioorganic & medicinal chemistry letters 2005;15(3):729-32.
2003: Chengxin Zhi; Zheng-Yu Long; Joseph J Gambino; Wei-Chu Xu; Neal C Brown; Marjorie Barnes; Michelle Butler; William A LaMarr; George E Wright
Synthesis of substituted 6-anilinouracils and their inhibition of DNA polymerase IIIC and Gram-positive bacterial growth.
Journal of medicinal chemistry 2003;46(13):2731-9.
2003: Kimberly A Foster; Marjorie H Barnes; Ryan O Stephenson; Michelle M Butler; Donna J Skow; William A LaMarr; Neal C Brown
DNA polymerase III of Enterococcus faecalis: expression and characterization of recombinant enzymes encoded by the polC and dnaE genes.
Protein expression and purification 2003;27(1):90-7.
2002: Marjorie H Barnes; Shelley D Miller; Neal C Brown
DNA polymerases of low-GC gram-positive eubacteria: identification of the replication-specific enzyme encoded by dnaE.
Journal of bacteriology 2002;184(14):3834-8.
2000: Jennifer S Daly; T J Giehl; Neal C Brown; Chengxin Zhi; George E Wright; Richard Ellison
In vitro antimicrobial activities of novel anilinouracils which selectively inhibit DNA polymerase III of gram-positive bacteria.
Antimicrobial agents and chemotherapy 2000;44(8):2217-21.
1999: Paul M Tarantino; Chengxin Zhi; George E Wright; Neal C Brown
Inhibitors of DNA polymerase III as novel antimicrobial agents against gram-positive eubacteria.
Antimicrobial agents and chemotherapy 1999;43(8):1982-7.
1999: Paul M Tarantino; Chengxin Zhi; Joseph J Gambino; George E Wright; Neal C Brown
6-Anilinouracil-based inhibitors of Bacillus subtilis DNA polymerase III: antipolymerase and antimicrobial structure-activity relationships based on substitution at uracil N3.
Journal of medicinal chemistry 1999;42(11):2035-40.
1998: Marjorie H Barnes; CJ Leo; Neal C Brown
DNA polymerase III of Gram-positive eubacteria is a zinc metalloprotein conserving an essential finger-like domain.
Biochemistry 1998;37(44):15254-60.
1995: D F Pacitti; M H Barnes; D H Li; Neal C Brown
Characterization and overexpression of the gene encoding Staphylococcus aureus DNA polymerase III.
Gene 1995;165(1):51-6.
1995: M H Barnes; P Spacciapoli; D H Li; Neal C Brown
The 3'-5' exonuclease site of DNA polymerase III from gram-positive bacteria: definition of a novel motif structure.
Gene 1995;165(1):45-50.
1995: M H Barnes; Neal C Brown
Purification of DNA polymerase III of gram-positive bacteria.
Methods in enzymology 1995;262():35-42.
1995: Neal C Brown; George E Wright
Mechanisms of inhibition of DNA polymerases by 2'-deoxyribonucleoside 5'-triphosphate analogs.
Methods in enzymology 1995;262():202-17.
1994: M H Barnes; Paul M Tarantino; P Spacciapoli; Neal C Brown; H Yu; K Dybvig
DNA polymerase III of Mycoplasma pulmonis: isolation and characterization of the enzyme and its structural gene, polC.
Molecular microbiology 1994;13(5):843-54.
1992: R A Hammond; Neal C Brown
Overproduction and purification of Bacillus subtilis DNA polymerase III.
Protein expression and purification 1992;3(1):65-70.
1992: M H Barnes; R A Hammond; C C Kennedy; S L Mack; Neal C Brown
Localization of the exonuclease and polymerase domains of Bacillus subtilis DNA polymerase III.
Gene 1992;111(1):43-9.
1991: N N Khan; George E Wright; Neal C Brown
The molecular mechanism of inhibition of alpha-type DNA polymerases by N2-(butylphenyl)dGTP and 2-(butylanilino)dATP: variation in susceptibility to polymerization.
Nucleic acids research 1991;19(7):1627-32.
1991: R A Hammond; M H Barnes; S L Mack; J A Mitchener; Neal C Brown
Bacillus subtilis DNA polymerase III: complete sequence, overexpression, and characterization of the polC gene.
Gene 1991;98(1):29-36.
1990: M M Butler; L W Dudycz; N N Khan; George E Wright; Neal C Brown
Development of novel inhibitor probes of DNA polymerase III based on dGTP analogs of the HPUra type: base, nucleoside and nucleotide derivatives of N2-(3,4-dichlorobenzyl)guanine.
Nucleic acids research 1990;18(24):7381-7.
1990: L Arabshahi; N N Khan; M Butler; T Noonan; Neal C Brown; George E Wright
(Difluoromethylene)phosphates of guanine nucleosides as probes of DNA polymerases and G proteins.
Biochemistry 1990;29(29):6820-6.
1990: George E Wright; Neal C Brown
Deoxyribonucleotide analogs as inhibitors and substrates of DNA polymerases.
Pharmacology & therapeutics 1990;47(3):447-97.
1989: M H Barnes; R A Hammond; K A Foster; J A Mitchener; Neal C Brown
The cloned polC gene of Bacillus subtilis: characterization of the azp12 mutation and controlled in vitro synthesis of active DNA polymerase III.
Gene 1989;85(1):177-86.
1989: Robert Talanian; Neal C Brown; C E McKenna; T G Ye; J N Levy; George E Wright
Carbonyldiphosphonate, a selective inhibitor of mammalian DNA polymerase delta.
Biochemistry 1989;28(21):8270-4.
1988: R A Hammond; K A Foster; M W Berchthold; Max Gassmann; A M Holmes; U Hübscher; Neal C Brown
Calcium-dependent calmodulin-binding proteins associated with mammalian DNA polymerase alpha.
Biochimica et biophysica acta 1988;951(2-3):315-21.
1987: Ulrich Hübscher; Max Gassmann; S Spadari; Neal C Brown; E Ferrari; H J Buhk
Mammalian DNA polymerase alpha: a replication-competent holoenzyme form from calf thymus.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1987;317(1187):421-8.
1987: George E Wright; L W Dudycz; Z Kazimierczuk; Neal C Brown; N N Khan
Synthesis, cell growth inhibition, and antitumor screening of 2-(p-n-butylanilino)purines and their nucleoside analogues.
Journal of medicinal chemistry 1987;30(1):109-16.
1986: D J Trantolo; George E Wright; Neal C Brown
Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines.
Journal of medicinal chemistry 1986;29(5):676-81.
1986: R W Ott; M H Barnes; Neal C Brown; A T Ganesan
Cloning and characterization of the polC region of Bacillus subtilis.
Journal of bacteriology 1986;165(3):951-7.
1986: Neal C Brown; L W Dudycz; George E Wright
Rational design of substrate analogues targeted to selectively inhibit replication-specific DNA polymerases.
Drugs under experimental and clinical research 1986;12(6-7):555-64.
1985: N N Khan; Neal C Brown
Purification and characterization of DNA polymerase alpha of Chinese hamster ovary cells.
Molecular and cellular biochemistry 1985;68(2):169-79.
1985: N N Khan; George E Wright; L W Dudycz; Neal C Brown
Elucidation of the mechanism of selective inhibition of mammalian DNA polymerase alpha by 2-butylanilinopurines: development and characterization of 2-(p-n-butylanilino)adenine and its deoxyribonucleotides.
Nucleic acids research 1985;13(17):6331-42.
1985: George E Wright; Neal C Brown
Inhibition of RNA-directed DNA polymerase from avian myeloblastosis virus by a 5-benzyl-6-aminouracil.
Biochemical and biophysical research communications 1985;126(1):109-16.
1984: N N Khan; George E Wright; L W Dudycz; Neal C Brown
Butylphenyl dGTP: a selective and potent inhibitor of mammalian DNA polymerase alpha.
Nucleic acids research 1984;12(8):3695-706.
1982: George E Wright; E F Baril; V M Brown; Neal C Brown
Design and characterization of N2-arylaminopurines which selectively inhibit replicative DNA synthesis and replication-specific DNA polymerases: guanine derivatives active on mammalian DNA polymerase alpha and bacterial DNA polymerase III.
Nucleic acids research 1982;10(14):4431-40.
1980: George E Wright; E F Baril; Neal C Brown
Butylanilinouracil: a selective inhibitor of HeLa cell DNA synthesis and HeLa cell DNA polymerase alpha.
Nucleic acids research 1980;8(1):99-109.
1980: George E Wright; Neal C Brown
Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils.
Journal of medicinal chemistry 1980;23(1):34-8.