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Nick Brown

Research Profile

Chemicals & Drugs

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Min Lu; Mark R Middleton; Indrika Ratnayaka; Victoria Salter; Christian Siebold; Alex Sullivan; Elena V Sviderskaya; Shan Zhong; Caroline Baer; Hilde Breyssens; Nick R Brown; Otavia L Caballero; Jonathan Cebon; Jane Endicott; Colin R Goding; Ying Hu; Thomas John; E Yvonne Jones; Benedikt M Kessler; Stefan Knapp; Xin Lu
Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP.
Christiane Riedinger; Jonas Boehringer; Jean-Francois Trempe; Edward D Lowe; Nick R Brown; Kalle Gehring; Martin E M Noble; Colin Gordon; Jane A Endicott
Structure of Rpn10 and its interactions with polyubiquitin chains and the proteasome subunit Rpn12.
Nick R Brown; Edward D Lowe; Ed Petri; Vicky Skamnaki; Robin Antrobus; Louise N Johnson
Cyclin B and cyclin A confer different substrate recognition properties on CDK2.

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All Publications

2013: Min Lu; Mark R Middleton; Indrika Ratnayaka; Victoria Salter; Christian Siebold; Alex Sullivan; Elena V Sviderskaya; Shan Zhong; Caroline Baer; Hilde Breyssens; Nick R Brown; Otavia L Caballero; Jonathan Cebon; Jane Endicott; Colin R Goding; Ying Hu; Thomas John; E Yvonne Jones; Benedikt M Kessler; Stefan Knapp; Xin Lu
Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP.
Cancer cell 2013;23(5):618-33.
2010: Christiane Riedinger; Jonas Boehringer; Jean-Francois Trempe; Edward D Lowe; Nick R Brown; Kalle Gehring; Martin E M Noble; Colin Gordon; Jane A Endicott
Structure of Rpn10 and its interactions with polyubiquitin chains and the proteasome subunit Rpn12.
The Journal of biological chemistry 2010;285(44):33992-4003.
2007: Nick R Brown; Edward D Lowe; Ed Petri; Vicky Skamnaki; Robin Antrobus; Louise N Johnson
Cyclin B and cyclin A confer different substrate recognition properties on CDK2.
Cell cycle (Georgetown, Tex.) 2007;6(11):1350-9.
2006: Robert Cheng; Martin E M Noble; Vicky Skamnaki; Nick R Brown; Edward D Lowe; Luke Kontogiannis; Kui Shen; Philip A Cole; Giuliano Siligardi; Louise N Johnson
The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition.
The Journal of biological chemistry 2006;281(32):23167-79.
2006: Edward D Lowe; Na'il Hasan; Jean-Francois Trempe; Laura Fonso; Martin E M Noble; Jane A Endicott; Louise N Johnson; Nick R Brown
Structures of the Dsk2 UBL and UBA domains and their complex.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 2):177-88.
2005: Jean-Francois Trempe; Nick R Brown; Edward D Lowe; Colin Gordon; Iain D Campbell; Martin E M Noble; Jane A Endicott
Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domain.
The EMBO journal 2005;24(18):3178-89.
2005: Reiko Honda; Edward D Lowe; Elena Dubinina; Vicky Skamnaki; Atlanta Cook; Nick R Brown; Louise N Johnson
The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles.
The EMBO journal 2005;24(3):452-63.
2004: Graziano Lolli; Edward D Lowe; Nick R Brown; Louise N Johnson
The crystal structure of human CDK7 and its protein recognition properties.
Structure (London, England : 1993) 2004;12(11):2067-79.
2003: Erika De Moliner; Nick R Brown; Louise N Johnson
Alternative binding modes of an inhibitor to two different kinases.
European journal of biochemistry / FEBS 2003;270(15):3174-81.
2002: Edward D Lowe; Ivo Tews; Robert Cheng; Nick R Brown; Sheraz Gul; Martin E M Noble; Steven J Gamblin; Louise N Johnson
Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A.
Biochemistry 2002;41(52):15625-34.
2002: Louise N Johnson; Erika De Moliner; Nick R Brown; Haiwei Song; David Barford; Jane A Endicott; Martin E M Noble
Structural studies with inhibitors of the cell cycle regulatory kinase cyclin-dependent protein kinase 2.
Pharmacology & therapeutics 2002;93(2-3):113-24.
2001: AM Lawrie; Paula Tito; H Hernandez; Nick R Brown; Carol V Robinson; Jane A Endicott; Martin E M Noble; Louise N Johnson
Xenopus phospho-CDK7/cyclin H expressed in baculoviral-infected insect cells.
Protein expression and purification 2001;23(2):252-60.
2001: H Song; N Hanlon; Nick R Brown; Martin E M Noble; Louise N Johnson; David Barford
Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2.
Molecular cell 2001;7(3):615-26.
1999: Nick R Brown; Martin E M Noble; Jane A Endicott; Louise N Johnson
The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases.
Nature cell biology 1999;1(7):438-43.
1999: Nick R Brown; Martin E M Noble; AM Lawrie; M C Morris; P Tunnah; G Divita; Louise N Johnson; Jane A Endicott
Effects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activity.
The Journal of biological chemistry 1999;274(13):8746-56.
1997: Martin E M Noble; Jane A Endicott; Nick R Brown; Louise N Johnson
The cyclin box fold: protein recognition in cell-cycle and transcription control.
Trends in biochemical sciences 1997;22(12):482-7.
1997: AM Lawrie; Martin E M Noble; P Tunnah; Nick R Brown; Louise N Johnson; Jane A Endicott
Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2.
Nature structural biology 1997;4(10):796-801.
1995: Nick R Brown; Martin E M Noble; Jane A Endicott; Elspeth F Garman; S Wakatsuki; E Mitchell; B Rasmussen; Tim Hunt; Louise N Johnson
The crystal structure of cyclin A.
Structure (London, England : 1993) 1995;3(11):1235-47.
1993: C Crawford; Nick R Brown; Antony C Willis
Studies of the active site of m-calpain and the interaction with calpastatin.
The Biochemical journal 1993;296 ( Pt 1)():135-42.
1990: C Crawford; Nick R Brown; Antony C Willis
Investigation of the structural basis of the interaction of calpain II with phospholipid and with carbohydrate.
The Biochemical journal 1990;265(2):575-9.