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Ralf Michael Zwacka

Research Profile

Living Beings

Chemicals & Drugs

Anatomy

Tumor Cell Line

Procedures

Genetic Therapy

Physiology

Devices

Gene Transfer Techniques

Genes & Molecular Sequences

Transgenes

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Publications

TOP 3
R Yu; Stella Maris Albarenque; L Deedigan; Andrea Mohr; Ralf Michael Zwacka
Delivery of sTRAIL variants by MSCs in combination with cytotoxic drug treatment leads to p53-independent enhanced antitumor effects.
Chirlei Klein Büneker; Laura Deedigan; Andrea Mohr; Rui Yu; Ralf Michael Zwacka
IFN-γ combined with targeting of XIAP leads to increased apoptosis-sensitisation of TRAIL resistant pancreatic carcinoma cells.
Stella Maris Albarenque; Ralf Michael Zwacka; Andrea Mohr
Both human and mouse mesenchymal stem cells promote breast cancer metastasis.

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All Publications

2013: R Yu; Stella Maris Albarenque; L Deedigan; Andrea Mohr; Ralf Michael Zwacka
Delivery of sTRAIL variants by MSCs in combination with cytotoxic drug treatment leads to p53-independent enhanced antitumor effects.
Cell death & disease 2013;4():e503.
2012: Chirlei Klein Büneker; Laura Deedigan; Andrea Mohr; Rui Yu; Ralf Michael Zwacka
IFN-γ combined with targeting of XIAP leads to increased apoptosis-sensitisation of TRAIL resistant pancreatic carcinoma cells.
Cancer letters 2012;316(2):168-77.
2011: Stella Maris Albarenque; Ralf Michael Zwacka; Andrea Mohr
Both human and mouse mesenchymal stem cells promote breast cancer metastasis.
Stem cell research 2011;7(2):163-71.
2010: Dominic Stadel; Andrea Mohr; Caroline Ref; Marion MacFarlane; Shaoxia Zhou; Robin Humphreys; Max G Bachem; Gerry Cohen; Peter Möller; Ralf Michael Zwacka; Klaus-Michael Debatin; Simone Fulda
TRAIL-induced apoptosis is preferentially mediated via TRAIL receptor 1 in pancreatic carcinoma cells and profoundly enhanced by XIAP inhibitors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(23):5734-49.
2010: Andrea Mohr; Stella Maris Albarenque; Laura Deedigan; Rui Yu; Mairead Reidy; Simone Fulda; Ralf Michael Zwacka
Targeting of XIAP combined with systemic mesenchymal stem cell-mediated delivery of sTRAIL ligand inhibits metastatic growth of pancreatic carcinoma cells.
Stem cells (Dayton, Ohio) 2010;28(11):2109-20.
2009: Chirlei Büneker; Andrea Mohr; Ralf Michael Zwacka
The TRAIL-receptor-1: TRAIL-receptor-3 and -4 ratio is a predictor for TRAIL sensitivity of cancer cells.
Oncology reports 2009;21(5):1289-95.
2008: Andrea Mohr; Mark Lyons; Laura Deedigan; Tina Harte; Georgina Shaw; Linda Howard; Frank P Barry; Tim O'Brien; Ralf Michael Zwacka
Mesenchymal stem cells expressing TRAIL lead to tumour growth inhibition in an experimental lung cancer model.
Journal of cellular and molecular medicine 2008;12(6B):2628-43.
2008: Thomas V A Murray; Jill M McMahon; Breege A Howley; Alanna Stanley; Thomas Ritter; Andrea Mohr; Ralf Michael Zwacka; Howard Fearnhead
A non-apoptotic role for caspase-9 in muscle differentiation.
Journal of cell science 2008;121(Pt 22):3786-93.
2008: Andrea Mohr; C Büneker; R P Gough; Ralf Michael Zwacka
MnSOD protects colorectal cancer cells from TRAIL-induced apoptosis by inhibition of Smac/DIABLO release.
Oncogene 2008;27(6):763-74.
2007: Andrea Mohr; Ralf Michael Zwacka
In situ trapping of initiator caspases reveals intermediate surprises.
Cell biology international 2007;31(5):526-30.
2007: Andrea Mohr; M Lyons; W Mohr; Ralf Michael Zwacka
[Gene therapy strategies for colorectal cancer].
Deutsche medizinische Wochenschrift (1946) 2007;132(11):567-70.
2007: K La Ferla-Brühl; Mike-Andrew Westhoff; S Karl; Hubert Kasperczyk; Ralf Michael Zwacka; Klaus-Michael Debatin; Simone Fulda
NF-kappaB-independent sensitization of glioblastoma cells for TRAIL-induced apoptosis by proteasome inhibition.
Oncogene 2007;26(4):571-82.
2007: Hans Weiher; Ralf Michael Zwacka
Vitamin D3-24-hydroxylase (CYP24) as a potential target for intervention with diabetic and nondiabetic nephropathy.
Clinical laboratory 2007;53(1-2):85-8.
2006: Susanne J Braeuer; Chirlei Büneker; Andrea Mohr; Ralf Michael Zwacka
Constitutively activated nuclear factor-kappaB, but not induced NF-kappaB, leads to TRAIL resistance by up-regulation of X-linked inhibitor of apoptosis protein in human cancer cells.
Molecular cancer research : MCR 2006;4(10):715-28.
2005: Hubert Kasperczyk; Katia La Ferla-Brühl; Mike-Andrew Westhoff; Lars Behrend; Ralf Michael Zwacka; Klaus-Michael Debatin; Simone Fulda
Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy.
Oncogene 2005;24(46):6945-56.
2005: Lars Behrend; Andrea Mohr; Tatjana Dick; Ralf Michael Zwacka
Manganese superoxide dismutase induces p53-dependent senescence in colorectal cancer cells.
Molecular and cellular biology 2005;25(17):7758-69.
2005: Andrea Mohr; Ralf Michael Zwacka; Gergely Jarmy; Chirlei Büneker; Hubert Schrezenmeier; Konstanze Döhner; Christian Beltinger; Markus Wiesneth; Klaus-Michael Debatin; Karsten Stahnke
Caspase-8L expression protects CD34+ hematopoietic progenitor cells and leukemic cells from CD95-mediated apoptosis.
Oncogene 2005;24(14):2421-9.
2004: A Mohr; Ralf Michael Zwacka; Klaus-Michael Debatin; Karsten Stahnke
A novel method for the combined flow cytometric analysis of cell cycle and cytochrome c release.
Cell death and differentiation 2004;11(10):1153-4.
2004: Andrea Mohr; G Henderson; Lorita Dudus; I Herr; T Kuerschner; K-M Debatin; Hans Weiher; Krishna J Fisher; Ralf Michael Zwacka
AAV-encoded expression of TRAIL in experimental human colorectal cancer leads to tumor regression.
Gene therapy 2004;11(6):534-43.
2003: Lars Behrend; G Henderson; Ralf Michael Zwacka
Reactive oxygen species in oncogenic transformation.
Biochemical Society transactions 2003;31(Pt 6):1441-4.
2001: Weihong Zhou; Yulong Zhang; M S Hosch; A Lang; Ralf Michael Zwacka; John F Engelhardt
Subcellular site of superoxide dismutase expression differentially controls AP-1 activity and injury in mouse liver following ischemia/reperfusion.
Hepatology (Baltimore, Md.) 2001;33(4):902-14.
2001: M Zanetti; Ralf Michael Zwacka; J Engelhardt; Zvonimir S Katusic; Timothy O'Brien
Superoxide anions and endothelial cell proliferation in normoglycemia and hyperglycemia.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(2):195-200.
2000: E W Lam; H M Hammad; Ralf Michael Zwacka; C J Darby; KR Baumgardner; B L Davidson; Terry D Oberley; J F Engelhardt; Larry W Oberley
Immunolocalization and adenoviral vector-mediated manganese superoxide dismutase gene transfer to experimental oral tumors.
Journal of dental research 2000;79(6):1410-7.
1999: Martine Clozel; Patrick Hess; Walter Fischli; Bernd-Michael Löffler; Ralf Michael Zwacka; A Reuter; Hans Weiher
Age-dependent hypertension in Mpv17-deficient mice, a transgenic model of glomerulosclerosis and inner ear disease.
Experimental gerontology 1999;34(8):1007-15.
1999: M R Brown; Francis J Miller; W G Li; Andrew N Ellingson; J D Mozena; P Chatterjee; John F Engelhardt; Ralf Michael Zwacka; L W Oberley; Xiang Fang; Arthur A Spector; Neal L Weintraub
Overexpression of human catalase inhibits proliferation and promotes apoptosis in vascular smooth muscle cells.
Circulation research 1999;85(6):524-33.
1999: E W Lam; Ralf Michael Zwacka; Elisabeth A Seftor; Daniel R C Nieva; B L Davidson; J F Engelhardt; Mary J C Hendrix; Larry W Oberley
Effects of antioxidant enzyme overexpression on the invasive phenotype of hamster cheek pouch carcinoma cells.
Free radical biology & medicine 1999;27(5-6):572-9.
1999: C Fan; Ralf Michael Zwacka; J F Engelhardt
Therapeutic approaches for ischemia/reperfusion injury in the liver.
Journal of molecular medicine (Berlin, Germany) 1999;77(8):577-92.
1999: Michael W Epperly; JA Bray; S Krager; L M Berry; W Gooding; J F Engelhardt; Ralf Michael Zwacka; Elizabeth L Travis; Joel S Greenberger
Intratracheal injection of adenovirus containing the human MnSOD transgene protects athymic nude mice from irradiation-induced organizing alveolitis.
International journal of radiation oncology, biology, physics 1999;43(1):169-81.
1998: Y Joseph Woo; J C Zhang; Camasamudram Vijayasarathy; Ralf Michael Zwacka; J F Englehardt; Timothy J Gardner; H Lee Sweeney
Recombinant adenovirus-mediated cardiac gene transfer of superoxide dismutase and catalase attenuates postischemic contractile dysfunction.
Circulation 1998;98(19 Suppl):II255-60; discussion II260-1.
1998: Ralf Michael Zwacka; Yulong Zhang; Weihong Zhou; J Halldorson; John F Engelhardt
Ischemia/reperfusion injury in the liver of BALB/c mice activates AP-1 and nuclear factor kappaB independently of IkappaB degradation.
Hepatology (Baltimore, Md.) 1998;28(4):1022-30.
1998: A Reuter; Andrea Nestl; Ralf Michael Zwacka; Jan P Tuckermann; R Waldherr; E M Wagner; M Höyhtyä; Angela M Meyer zum Gottesberge; Peter Angel; Hans Weiher
Expression of the recessive glomerulosclerosis gene Mpv17 regulates MMP-2 expression in fibroblasts, the kidney, and the inner ear of mice.
Molecular biology of the cell 1998;9(7):1675-82.
1998: Xiang Fang; Neal L Weintraub; C D Rios; D A Chappell; Ralf Michael Zwacka; John F Engelhardt; L W Oberley; T Yan; Donald D Heistad; Arthur A Spector
Overexpression of human superoxide dismutase inhibits oxidation of low-density lipoprotein by endothelial cells.
Circulation research 1998;82(12):1289-97.
1998: Ralf Michael Zwacka; Lorita Dudus; M W Epperly; J S Greenberger; John F Engelhardt
Redox gene therapy protects human IB-3 lung epithelial cells against ionizing radiation-induced apoptosis.
Human gene therapy 1998;9(9):1381-6.
1998: Ralf Michael Zwacka; Weihong Zhou; Yulong Zhang; C J Darby; Lorita Dudus; J Halldorson; L Oberley; John F Engelhardt
Redox gene therapy for ischemia/reperfusion injury of the liver reduces AP1 and NF-kappaB activation.
Nature medicine 1998;4(6):698-704.
1998: Michael W Epperly; J Bray; S Kraeger; Ralf Michael Zwacka; J Engelhardt; Elizabeth L Travis; Joel S Greenberger
Prevention of late effects of irradiation lung damage by manganese superoxide dismutase gene therapy.
Gene therapy 1998;5(2):196-208.
1997: E W Lam; Ralf Michael Zwacka; J F Engelhardt; B L Davidson; Frederick E Domann; T Yan; Larry W Oberley
Adenovirus-mediated manganese superoxide dismutase gene transfer to hamster cheek pouch carcinoma cells.
Cancer research 1997;57(24):5550-6.
1997: Marcus Müller; Jean W T Smolders; Angela M Meyer zum Gottesberge; A Reuter; Ralf Michael Zwacka; Hans Weiher; Rainer Klinke
Loss of auditory function in transgenic Mpv17-deficient mice.
Hearing research 1997;114(1-2):259-63.
1997: Ralf Michael Zwacka; Yulong Zhang; J Halldorson; H Schlossberg; Lorita Dudus; John F Engelhardt
CD4(+) T-lymphocytes mediate ischemia/reperfusion-induced inflammatory responses in mouse liver.
The Journal of clinical investigation 1997;100(2):279-89.
1995: Johannes Schenkel; Ralf Michael Zwacka; C Rutenberg; A Reuter; R Waldherr; Hans Weiher
Functional rescue of the glomerulosclerosis phenotype in Mpv17 mice by transgenesis with the human Mpv17 homologue.
Kidney international 1995;48(1):80-4.
1994: Ralf Michael Zwacka; A Reuter; E Pfaff; Jurgen Moll; K Gorgas; M Karasawa; Hans Weiher
The glomerulosclerosis gene Mpv17 encodes a peroxisomal protein producing reactive oxygen species.
The EMBO journal 1994;13(21):5129-34.
1993: M Karasawa; Ralf Michael Zwacka; A Reuter; T Fink; C L Hsieh; P Lichter; U Francke; Hans Weiher
The human homolog of the glomerulosclerosis gene Mpv17: structure and genomic organization.
Human molecular genetics 1993;2(11):1829-34.

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