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Markus Zweckstetter

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Mariusz Jaremko; Hai-Young Kim; Charles D Schwieters; Stefan Becker; Min-Kyu Cho; Karin Giller; Lukasz Jaremko; Markus Zweckstetter
Cold denaturation of a protein dimer monitored at atomic resolution.
Umesh Jinwal; Pengfei Li; Eckhard Mandelkow; Bryce A Nordhues; John C O'Leary; Andrea D Thompson; Vladimir N Uversky; Bo Zhang; Juan Zhang; Markus Zweckstetter; Jose F Abisambra; Elias Akoury; Justin Bacon; Jacek Biernat; Laura J Blair; Sergiy Borysov; Matthew Cockman; Jason E Gestwicki; Ying Jin; Chad A Dickey
Imbalance of Hsp70 family variants fosters tau accumulation.
Sheng-Qi Xiang; Stefan Becker; Raghavendran L Narayanan; Markus Zweckstetter
N-H spin-spin couplings: probing hydrogen bonds in proteins.

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2013: Mariusz Jaremko; Hai-Young Kim; Charles D Schwieters; Stefan Becker; Min-Kyu Cho; Karin Giller; Lukasz Jaremko; Markus Zweckstetter
Cold denaturation of a protein dimer monitored at atomic resolution.
Nature chemical biology 2013;9(4):264-70.
2013: Umesh Jinwal; Pengfei Li; Eckhard Mandelkow; Bryce A Nordhues; John C O'Leary; Andrea D Thompson; Vladimir N Uversky; Bo Zhang; Juan Zhang; Markus Zweckstetter; Jose F Abisambra; Elias Akoury; Justin Bacon; Jacek Biernat; Laura J Blair; Sergiy Borysov; Matthew Cockman; Jason E Gestwicki; Ying Jin; Chad A Dickey
Imbalance of Hsp70 family variants fosters tau accumulation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013;27(4):1450-9.
2013: Sheng-Qi Xiang; Stefan Becker; Raghavendran L Narayanan; Markus Zweckstetter
N-H spin-spin couplings: probing hydrogen bonds in proteins.
Angewandte Chemie (International ed. in English) 2013;52(12):3525-8.
2013: Elias Akoury; Jacek Biernat; Michal Gajda; Eckhard Mandelkow; Marcus Pickhardt; Markus Zweckstetter
Mechanistic basis of phenothiazine-driven inhibition of Tau aggregation.
Angewandte Chemie (International ed. in English) 2013;52(12):3511-5.
2013: Elias Akoury; Jacek Biernat; Michal Gajda; Christian Griesinger; Eckhard Mandelkow; Marcus Pickhardt; Pornsuwan Soraya; Markus Zweckstetter
Inhibition of tau filament formation by conformational modulation.
Journal of the American Chemical Society 2013;135(7):2853-62.
2013: Lukasz Skora; Henning Urlaub; Jens Watzlawik; Stefan Becker; Luis Fonseca-Ornelas; Karin Giller; Romina V Hofele; Dietmar Riedel; Walter Schulz-Schaeffer; Markus Zweckstetter
Burial of the polymorphic residue 129 in amyloid fibrils of prion stop mutants.
The Journal of biological chemistry 2013;288(5):2994-3002.
2013: Francesca Munari; Nasrollah Rezaei-Ghaleh; Shengqi Xiang; Wolfgang Fischle; Markus Zweckstetter
Structural plasticity in human heterochromatin protein 1β.
PloS one 2013;8(4):e60887.
2012: Lukasz Skora; Markus Zweckstetter
Determination of amyloid core structure using chemical shifts.
Protein science : a publication of the Protein Society 2012;21(12):1948-53.
2012: Heiko Kroth; Hilal A Lashuel; Sophie Lohmann; María Pilar López-Deber; Oskar Adolfsson; Annalisa Ansaloni; Wolfgang Froestl; Valérie Giriens; Asad Jan; Luitgard Nagel-Steger; Paolo Paganetti; Andrea Pfeifer; Maria Pihlgren; Nasrollah Rezaei-Ghaleh; Thomas Schrader; Nampally Sreenivasachary; Yvan Varisco; Dieter Willbold; Markus Zweckstetter; Andreas Muhs
Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation.
The Journal of biological chemistry 2012;287(41):34786-800.
2012: Francesca Munari; Nasrollah Rezaei-Ghaleh; Adrian Schomburg; Sabrina Schröder; Dirk Schwarzer; Szabolcs Soeroes; Alexandra Stützer; Peter Jomo Walla; Hans Michael Zenn; Bastian Zimmermann; Stefan Becker; Wolfgang Fischle; Kathy Ann Gelato; Rebecca Klingberg; Nils Kost; Markus Zweckstetter
Methylation of lysine 9 in histone H3 directs alternative modes of highly dynamic interaction of heterochromatin protein hHP1β with the nucleosome.
The Journal of biological chemistry 2012;287(40):33756-65.
2012: Valéry Ozenne; Loïc Salmon; Robert Schneider; Mingxi Yao; Markus Zweckstetter; Jie-rong Huang; Malene Ringkjøbing Jensen; Martin Blackledge
Mapping the potential energy landscape of intrinsically disordered proteins at amino acid resolution.
Journal of the American Chemical Society 2012;134(36):15138-48.
2012: Ulrich Zachariae; Markus Zweckstetter; Elke Maier; Robert Schneider; Stefan Becker; Roland Benz; Rodolfo Briones; Bert L de Groot; Jean-Philippe Demers; Zrinka Gattin; Karin Giller; Christian Griesinger; Adam Lange
β-Barrel mobility underlies closure of the voltage-dependent anion channel.
Structure (London, England : 1993) 2012;20(9):1540-9.
2012: Venita Daebel; Christian Griesinger; Birgit Habenstein; Elias Akoury; Marc Baldus; Jacek Biernat; Subashchandrabose Chinnathambi; Antoine Loquet; Eckhard Mandelkow; Henrik Müller; Martin Schwalbe; Katharina Tepper; Vinesh Vijayan; Markus Zweckstetter; Adam Lange
β-Sheet core of tau paired helical filaments revealed by solid-state NMR.
Journal of the American Chemical Society 2012;134(34):13982-9.
2012: Robert Berger; Jacques Courtieu; Roberto R Gil; Christian Griesinger; Matthias Köck; Philippe Lesot; Burkhard Luy; Denis Merlet; Armando Navarro-Vázquez; Michael Reggelin; Uwe M Reinscheid; Christina M Thiele; Markus Zweckstetter
Is enantiomer assignment possible by NMR spectroscopy using residual dipolar couplings from chiral nonracemic alignment media?--A critical assessment.
Angewandte Chemie (International ed. in English) 2012;51(33):8388-91.
2012: Doris Petroi; Blagovesta Popova; Hedieh Shahpasandzadeh; Naimeh Taheri-Talesh; Markus Zweckstetter; Stefan Irniger; Tiago F Outeiro; Gerhard H Braus
Aggregate clearance of α-synuclein in Saccharomyces cerevisiae depends more on autophagosome and vacuole function than on the proteasome.
The Journal of biological chemistry 2012;287(33):27567-79.
2012: Nasrollah Rezaei-Ghaleh; Martin Blackledge; Markus Zweckstetter
Intrinsically disordered proteins: from sequence and conformational properties toward drug discovery.
Chembiochem : a European journal of chemical biology 2012;13(7):930-50.
2012: Grit Taschenberger; Yuliya Tereshchenko; Markus Zweckstetter; Mathias Bähr; Manuel Garrido; Sebastian Kügler
Aggregation of αSynuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons.
Acta neuropathologica 2012;123(5):671-83.
2012: Farah El-Turk; Bruno Fauvet; Amer Ashrafi; Michele Cascella; Min-Kyu Cho; Marilisa Neri; Hajer Ouertatani-Sakouhi; Florence Pojer; Ursula Rothlisberger; Markus Zweckstetter; Hilal A Lashuel
Characterization of molecular determinants of the conformational stability of macrophage migration inhibitory factor: leucine 46 hydrophobic pocket.
PloS one 2012;7(9):e45024.
2012: Min-Kyu Cho; Hai-Young Kim; Shengqi Xiang; Stefan Becker; Markus Zweckstetter
Cold-induced changes in the protein ubiquitin.
PloS one 2012;7(6):e37270.
2011: Stefan Bibow; Jacek Biernat; Subashchandrabose Chinnathambi; Christian Griesinger; Eckhard Mandelkow; Marco D Mukrasch; Markus Zweckstetter
The dynamic structure of filamentous tau.
Angewandte Chemie (International ed. in English) 2011;50(48):11520-4.
2011: Stefan Bibow; Jacek Biernat; Martin Blackledge; Eckhard Mandelkow; Valéry Ozenne; Markus Zweckstetter
Structural impact of proline-directed pseudophosphorylation at AT8, AT100, and PHF1 epitopes on 441-residue tau.
Journal of the American Chemical Society 2011;133(40):15842-5.
2011: Gonzalo R Lamberto; Xavier Salvatella; Valentina Torres-Monserrat; Markus Zweckstetter; CARLOS WALTER BERTONCINI; Christian Griesinger; Claudio O Fernández
Toward the discovery of effective polycyclic inhibitors of alpha-synuclein amyloid assembly.
The Journal of biological chemistry 2011;286(37):32036-44.
2011: Nasrollah Rezaei-Ghaleh; Stefan Becker; Karin Giller; Markus Zweckstetter
Effect of zinc binding on β-amyloid structure and dynamics: implications for Aβ aggregation.
Biophysical journal 2011;101(5):1202-11.
2011: Petranka Krumova; Sebastian Kügler; Frauke Melchior; Erik Meulmeester; Marilyn Tirard; Henning Urlaub; Mathias Bähr; Guillaume Bossis; Manuel Garrido; He-Hsuan Hsiao; Markus Zweckstetter; Jochen H Weishaupt
Sumoylation inhibits alpha-synuclein aggregation and toxicity.
The Journal of cell biology 2011;194(1):49-60.
2011: Sathish Kumar; Nasrollah Rezaei-Ghaleh; Dick Terwel; Dietmar R Thal; Mélisande Richard; Michael Hoch; Jessica M Mc Donald; Ullrich Wüllner; Konstantin Glebov; Michael T Heneka; Dominic M Walsh; Markus Zweckstetter; Jochen Walter
Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease.
The EMBO journal 2011;30(11):2255-65.
2011: Min-Kyu Cho; Hai-Young Kim; Claudio O Fernandez; Stefan Becker; Markus Zweckstetter
Conserved core of amyloid fibrils of wild type and A30P mutant α-synuclein.
Protein science : a publication of the Protein Society 2011;20(2):387-95.
2011: Tim Gruene; Min-Kyu Cho; Irina Karyagina; Hai-Young Kim; Christian Grosse; Karin Giller; Markus Zweckstetter; Stefan Becker
Integrated analysis of the conformation of a protein-linked spin label by crystallography, EPR and NMR spectroscopy.
Journal of biomolecular NMR 2011;49(2):111-9.
2011: Andrés Binolfi; Rosario Duran; Christian Griesinger; Ariel A Valiente-Gabioud; Markus Zweckstetter; Claudio O Fernandez
Exploring the structural details of Cu(I) binding to α-synuclein by NMR spectroscopy.
Journal of the American Chemical Society 2011;133(2):194-6.
2011: Madhu Babu Gajula Balija; Christian Griesinger; Alf Herzig; Markus Zweckstetter; Herbert Jäckle
Pre-fibrillar α-synuclein mutants cause Parkinson's disease-like non-motor symptoms in Drosophila.
PloS one 2011;6(9):e24701.
2011: Nasrollah Rezaei-Ghaleh; Erika Andreetto; Li-Mei Yan; Aphrodite Kapurniotu; Markus Zweckstetter
Interaction between amyloid beta peptide and an aggregation blocker peptide mimicking islet amyloid polypeptide.
PloS one 2011;6(5):e20289.
2010: Saskia Villinger; Rodolfo Briones; Karin Giller; Ulrich Zachariae; Adam Lange; Bert L de Groot; Christian Griesinger; Stefan Becker; Markus Zweckstetter
Functional dynamics in the voltage-dependent anion channel.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(52):22546-51.
2010: Andrés Binolfi; Esaú E Rodriguez; Daniela Valensin; Nicola D'Amelio; Emiliano Ippoliti; Gonzalo Obal; Rosario Duran; Alessandra Magistrato; Otto Pritsch; Markus Zweckstetter; Gianni Valensin; Paolo Carloni; Liliana Quintanar; Christian Griesinger; Claudio O Fernández
Bioinorganic chemistry of Parkinson's disease: structural determinants for the copper-mediated amyloid formation of alpha-synuclein.
Inorganic chemistry 2010;49(22):10668-79.
2010: Laura de la Cruz; Rakhi Bajaj; Stefan Becker; Markus Zweckstetter
The intermembrane space domain of Tim23 is intrinsically disordered with a distinct binding region for presequences.
Protein science : a publication of the Protein Society 2010;19(11):2045-54.
2010: Lukasz Skora; Stefan Becker; Markus Zweckstetter
Characterization of amyloid fibrils of human beta-2-microglobulin by high-resolution magic-angle spinning NMR.
Chembiochem : a European journal of chemical biology 2010;11(13):1829-32.
2010: Rhagavendran L Narayanan; Ulrich H. N. Dürr; Stefan Bibow; Jacek Biernat; Eckhard Mandelkow; Markus Zweckstetter
Automatic assignment of the intrinsically disordered protein Tau with 441-residues.
Journal of the American Chemical Society 2010;132(34):11906-7.
2010: Hajer Ouertatani-Sakouhi; Farah El-Turk; Bruno Fauvet; Min-Kyu Cho; Damla Pinar Karpinar; Didier Le Roy; Manfred Dewor; Thierry Roger; Jürgen Bernhagen; Thierry Calandra; Markus Zweckstetter; Hilal A Lashuel
Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action.
The Journal of biological chemistry 2010;285(34):26581-98.
2010: Lukasz Skora; Stefan Becker; Markus Zweckstetter
Molten globule precursor states are conformationally correlated to amyloid fibrils of human beta-2-microglobulin.
Journal of the American Chemical Society 2010;132(27):9223-5.
2010: Loïc Salmon; Gabrielle Nodet; Valéry Ozenne; Guowei Yin; Malene Ringkjøbing Jensen; Markus Zweckstetter; Martin Blackledge
NMR characterization of long-range order in intrinsically disordered proteins.
Journal of the American Chemical Society 2010;132(24):8407-18.
2010: Varda Shoshan-Barmatz; Vito De Pinto; Markus Zweckstetter; Ziv Raviv; Nurit Keinan; Nir Arbel
VDAC, a multi-functional mitochondrial protein regulating cell life and death.
Molecular aspects of medicine 2010;31(3):227-85.
2010: Saviana Di Giovanni; Simona Eleuteri; Katerina E Paleologou; Guowei Yin; Markus Zweckstetter; Pierre-Alain Carrupt; Hilal A Lashuel
Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity.
The Journal of biological chemistry 2010;285(20):14941-54.
2010: Katerina E Paleologou; Abid Oueslati; Gideon Shakked; Carla C Rospigliosi; Hai-Young Kim; Gonzalo R Lamberto; Claudio O Fernandez; Adrian Schmid; Fariba Chegini; Wei Ping Gai; Diego Chiappe; Marc Moniatte; Bernard L Schneider; Patrick Aebischer; David Eliezer; Markus Zweckstetter; Eliezer Masliah; Hilal A Lashuel
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(9):3184-98.
2010: Robert Schneider; Manuel Etzkorn; Karin Giller; Venita Daebel; Jörg Eisfeld; Markus Zweckstetter; Christian Griesinger; Stefan Becker; Adam Lange
The native conformation of the human VDAC1 N terminus.
Angewandte Chemie (International ed. in English) 2010;49(10):1882-5.
2010: Martial K Mbefo; Katerina E Paleologou; Ahmed Boucharaba; Abid Oueslati; Heinrich Schell; Margot Fournier; Diana Olschewski; Guowei Yin; Markus Zweckstetter; Eliezer Masliah; Philipp J Kahle; Harald Hirling; Hilal A Lashuel
Phosphorylation of synucleins by members of the Polo-like kinase family.
The Journal of biological chemistry 2010;285(4):2807-22.
2009: Gonzalo R Lamberto; Andrés Binolfi; María L Orcellet; CARLOS WALTER BERTONCINI; Markus Zweckstetter; Christian Griesinger; Claudio O Fernández
Structural and mechanistic basis behind the inhibitory interaction of PcTS on alpha-synuclein amyloid fibril formation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(50):21057-62.
2009: Hai-Young Kim; Min-Kyu Cho; Ashutosh Kumar; Elke Maier; Carsten Siebenhaar; Stefan Becker; Claudio O Fernandez; Hilal A Lashuel; Roland Benz; Adam Lange; Markus Zweckstetter
Structural properties of pore-forming oligomers of alpha-synuclein.
Journal of the American Chemical Society 2009;131(47):17482-9.
2009: Daniela Fischer; Marco D Mukrasch; Jacek Biernat; Stefan Bibow; Martin Blackledge; Christian Griesinger; Eckhard Mandelkow; Markus Zweckstetter
Conformational changes specific for pseudophosphorylation at serine 262 selectively impair binding of tau to microtubules.
Biochemistry 2009;48(42):10047-55.
2009: Damla Pinar Karpinar; Madhu Babu Gajula Balija; Sebastian Kügler; Felipe Opazo; Nasrollah Rezaei-Ghaleh; Nora Wender; Hai-Young Kim; Grit Taschenberger; Björn H Falkenburger; Henrike Heise; Ashutosh Kumar; Dietmar Riedel; Lars Fichtner; Aaron Voigt; Gerhard H Braus; Karin Giller; Stefan Becker; Alf Herzig; Marc Baldus; Herbert Jäckle; Stefan Eimer; Jörg B Schulz; Christian Griesinger; Markus Zweckstetter
Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models.
The EMBO journal 2009;28(20):3256-68.
2009: Hajer Ouertatani-Sakouhi; Farah El-Turk; Bruno Fauvet; Thierry Roger; Didier Le Roy; Damla Pinar Karpinar; Lin Leng; Richard Bucala; Markus Zweckstetter; Thierry Calandra; Hilal A Lashuel
A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor.
Biochemistry 2009;48(41):9858-70.
2009: Malene Ringkjøbing Jensen; Phineus R L Markwick; Sebastian Meier; Christian Griesinger; Markus Zweckstetter; Stephan Grzesiek; Pau Bernadó; Martin Blackledge
Quantitative determination of the conformational properties of partially folded and intrinsically disordered proteins using NMR dipolar couplings.
Structure (London, England : 1993) 2009;17(9):1169-85.
2009: Min-Kyu Cho; Gabrielle Nodet; Hai-Young Kim; Malene R Jensen; Pau Bernado; Claudio O Fernandez; Stefan Becker; Martin Blackledge; Markus Zweckstetter
Structural characterization of alpha-synuclein in an aggregation prone state.
Protein science : a publication of the Protein Society 2009;18(9):1840-6.
2009: Marco D Mukrasch; Stefan Bibow; Jegannath Korukottu; Sadasivam Jeganathan; Jacek Biernat; Christian Griesinger; Eckhard Mandelkow; Markus Zweckstetter
Structural polymorphism of 441-residue tau at single residue resolution.
PLoS biology 2009;7(2):e34.
2009: Nasrollah Rezaei-Ghaleh; Markus Zweckstetter; Dina Morshedi; azadeh Ebrahim-Habibi; Mohsen Nemat-Gorgani
Amyloidogenic potential of alpha-chymotrypsin in different conformational states.
Biopolymers 2009;91(1):28-36.
2008: Sigrun Rumpel; Raghavendran Lakshmi; Stefan Becker; Markus Zweckstetter
Assignment-free solution NMR method reveals CesT as an unswapped homodimer.
Protein science : a publication of the Protein Society 2008;17(11):2015-9.
2008: Alice Soragni; Barbara Zambelli; Marco D Mukrasch; Jacek Biernat; Sadasivam Jeganathan; Christian Griesinger; Stefano Ciurli; Eckhard Mandelkow; Markus Zweckstetter
Structural characterization of binding of Cu(II) to tau protein.
Biochemistry 2008;47(41):10841-51.
2008: Monika Bayrhuber; Thomas Meins; Michael Habeck; Stefan Becker; Karin Giller; Saskia Villinger; Clemens Vonrhein; Christian Griesinger; Markus Zweckstetter; Kornelius Zeth
Structure of the human voltage-dependent anion channel.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(40):15370-5.
2008: Farah El-Turk; Michele Cascella; Hajer Ouertatani-Sakouhi; Raghavendran Lakshmi Narayanan; Lin Leng; Richard Bucala; Markus Zweckstetter; Ursula Rothlisberger; Hilal A Lashuel
The conformational flexibility of the carboxy terminal residues 105-114 is a key modulator of the catalytic activity and stability of macrophage migration inhibitory factor.
Biochemistry 2008;47(40):10740-56.
2008: Andrés Binolfi; Gonzalo R Lamberto; Rosario Duran; Liliana Quintanar; CARLOS WALTER BERTONCINI; Jose M Souza; Carlos Cerveñansky; Markus Zweckstetter; Christian Griesinger; Claudio O Fernández
Site-specific interactions of Cu(II) with alpha and beta-synuclein: bridging the molecular gap between metal binding and aggregation.
Journal of the American Chemical Society 2008;130(35):11801-12.
2008: Katerina E Paleologou; Adrien Schmid; Carla C Rospigliosi; Hai-Young Kim; Gonzalo R Lamberto; Ross A Fredenburg; Peter T Lansbury; Claudio O Fernandez; David Eliezer; Markus Zweckstetter; Hilal A Lashuel
Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.
The Journal of biological chemistry 2008;283(24):16895-905.
2008: Pierre Montaville; Nicolas Coudevylle; Anand Radhakrishnan; Andrei Leonov; Markus Zweckstetter; Stefan Becker
The PIP2 binding mode of the C2 domains of rabphilin-3A.
Protein science : a publication of the Protein Society 2008;17(6):1025-34.
2008: Madhumati Sevvana; Vinesh Vijayan; Markus Zweckstetter; Stefan Reinelt; Dean R Madden; Regine Herbst-Irmer; George M Sheldrick; Michael Bott; Christian Griesinger; Stefan Becker
A ligand-induced switch in the periplasmic domain of sensor histidine kinase CitA.
Journal of molecular biology 2008;377(2):512-23.
2008: Jegannath Korukottu; Robert Schneider; Vinesh Vijayan; Adam Lange; Olaf Pongs; Stefan Becker; Marc Baldus; Markus Zweckstetter
High-resolution 3D structure determination of kaliotoxin by solid-state NMR spectroscopy.
PloS one 2008;3(6):e2359.
2008: Hai-Young Kim; Min-Kyu Cho; Dietmar Riedel; Claudio O Fernandez; Markus Zweckstetter
Dissociation of amyloid fibrils of alpha-synuclein in supercooled water.
Angewandte Chemie (International ed. in English) 2008;47(27):5046-8.
2008: Markus Zweckstetter
NMR: prediction of molecular alignment from structure using the PALES software.
Nature protocols 2008;3(4):679-90.
2008: Sigrun Rumpel; Stefan Becker; Markus Zweckstetter
High-resolution structure determination of the CylR2 homodimer using paramagnetic relaxation enhancement and structure-based prediction of molecular alignment.
Journal of biomolecular NMR 2008;40(1):1-13.
2007: Hai-Young Kim; Henrike Heise; Claudio O Fernandez; Marc Baldus; Markus Zweckstetter
Correlation of amyloid fibril beta-structure with the unfolded state of alpha-synuclein.
Chembiochem : a European journal of chemical biology 2007;8(14):1671-4.
2007: CARLOS WALTER BERTONCINI; Rodolfo Maximiliano Rasia; Gonzalo R Lamberto; Andrés Binolfi; Markus Zweckstetter; Christian Griesinger; Claudio O Fernandez
Structural characterization of the intrinsically unfolded protein beta-synuclein, a natural negative regulator of alpha-synuclein aggregation.
Journal of molecular biology 2007;372(3):708-22.
2007: Marco D Mukrasch; Phineus R L Markwick; Jacek Biernat; Martin von Bergen; Pau Bernadó; Christian Griesinger; Eckhard Mandelkow; Markus Zweckstetter; Martin Blackledge
Highly populated turn conformations in natively unfolded tau protein identified from residual dipolar couplings and molecular simulation.
Journal of the American Chemical Society 2007;129(16):5235-43.
2007: Marco D Mukrasch; Martin von Bergen; Jacek Biernat; Daniela Fischer; Christian Griesinger; Eckhard Mandelkow; Markus Zweckstetter
The "jaws" of the tau-microtubule interaction.
The Journal of biological chemistry 2007;282(16):12230-9.
2007: Min-Kyu Cho; Hai-Young Kim; Pau Bernado; Claudio O Fernandez; Martin Blackledge; Markus Zweckstetter
Amino acid bulkiness defines the local conformations and dynamics of natively unfolded alpha-synuclein and tau.
Journal of the American Chemical Society 2007;129(11):3032-3.
2007: Daniela Fischer; Marco D Mukrasch; Martin von Bergen; Aleksandra Klos-Witkowska; Jacek Biernat; Christian Griesinger; Eckhard Mandelkow; Markus Zweckstetter
Structural and microtubule binding properties of tau mutants of frontotemporal dementias.
Biochemistry 2007;46(10):2574-82.
2007: Pierre Montaville; Christine Schlicker; Andrei Leonov; Markus Zweckstetter; George M Sheldrick; Stefan Becker
The C2A-C2B linker defines the high affinity Ca(2+) binding mode of rabphilin-3A.
The Journal of biological chemistry 2007;282(7):5015-25.
2007: Jegannath Korukottu; Monika Bayrhuber; Pierre Montaville; Vinesh Vijayan; Young-Sang Jung; Stefan Becker; Markus Zweckstetter
Fast high-resolution protein structure determination by using unassigned NMR data.
Angewandte Chemie (International ed. in English) 2007;46(7):1176-9.
2006: Lukasz Skora; Min-Kyu Cho; Hai-Young Kim; Stefan Becker; Claudio O Fernandez; Martin Blackledge; Markus Zweckstetter
Charge-induced molecular alignment of intrinsically disordered proteins.
Angewandte Chemie (International ed. in English) 2006;45(42):7012-5.
2006: Junji Iwahara; Markus Zweckstetter; G Marius Clore
NMR structural and kinetic characterization of a homeodomain diffusing and hopping on nonspecific DNA.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(41):15062-7.
2006: Jens Watzlawik; Lukasz Skora; Dieter Frense; Christian Griesinger; Markus Zweckstetter; Walter Schulz-Schaeffer; Michael L Kramer
Prion protein helix1 promotes aggregation but is not converted into beta-sheet.
The Journal of biological chemistry 2006;281(40):30242-50.
2006: Ralf Jauch; Min-Kyu Cho; Stefan Jäkel; Catharina Netter; Kay Schreiter; Babette Aicher; Markus Zweckstetter; Herbert Jäckle; Markus C Wahl
Mitogen-activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment.
The EMBO journal 2006;25(17):4020-32.
2006: Andrés Binolfi; Rodolfo Maximiliano Rasia; CARLOS WALTER BERTONCINI; Marcelo Ceolin; Markus Zweckstetter; Christian Griesinger; Thomas M Jovin; Claudio O Fernández
Interaction of alpha-synuclein with divalent metal ions reveals key differences: a link between structure, binding specificity and fibrillation enhancement.
Journal of the American Chemical Society 2006;128(30):9893-901.
2006: Monika Bayrhuber; Roland Graf; Michael Ferber; Markus Zweckstetter; Julita S Imperial; James E Garrett; Baldomero M Olivera; Heinrich Terlau; Stefan Becker
Production of recombinant Conkunitzin-S1 in Escherichia coli.
Protein expression and purification 2006;47(2):640-4.
2006: Pierre Montaville; Hai-Young Kim; Vinesh Vijayan; Stefan Becker; Markus Zweckstetter
1H, 15N, and 13C resonance assignment of the C2A domain of rabphilin 3A.
Journal of biomolecular NMR 2006;36 Suppl 1():20.
2006: Markus Zweckstetter
Prediction of charge-induced molecular alignment: residual dipolar couplings at pH 3 and alignment in surfactant liquid crystalline phases.
European biophysics journal : EBJ 2006;35(2):170-80.
2005: Pau Bernadó; CARLOS WALTER BERTONCINI; Christian Griesinger; Markus Zweckstetter; Martin Blackledge
Defining long-range order and local disorder in native alpha-synuclein using residual dipolar couplings.
Journal of the American Chemical Society 2005;127(51):17968-9.
2005: CARLOS WALTER BERTONCINI; Claudio O Fernandez; Christian Griesinger; Thomas M Jovin; Markus Zweckstetter
Familial mutants of alpha-synuclein with increased neurotoxicity have a destabilized conformation.
The Journal of biological chemistry 2005;280(35):30649-52.
2005: Jason R Schnell; Guo-Ping Zhou; Markus Zweckstetter; Alan Rigby; James J Chou
Rapid and accurate structure determination of coiled-coil domains using NMR dipolar couplings: application to cGMP-dependent protein kinase Ialpha.
Protein science : a publication of the Protein Society 2005;14(9):2421-8.
2005: Markus Zweckstetter; Jason R Schnell; James J Chou
Determination of the packing mode of the coiled-coil domain of cGMP-dependent protein kinase Ialpha in solution using charge-predicted dipolar couplings.
Journal of the American Chemical Society 2005;127(34):11918-9.
2005: Marco D Mukrasch; Jacek Biernat; Martin von Bergen; Christian Griesinger; Eckhard Mandelkow; Markus Zweckstetter
Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions.
The Journal of biological chemistry 2005;280(26):24978-86.
2005: Monika Bayrhuber; Vinesh Vijayan; Michael Ferber; Roland Graf; Jegannath Korukottu; Julita S Imperial; James E Garrett; Baldomero M Olivera; Heinrich Terlau; Markus Zweckstetter; Stefan Becker
Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family. Structural and functional characterization.
The Journal of biological chemistry 2005;280(25):23766-70.
2005: Vinesh Vijayan; Markus Zweckstetter
Simultaneous measurement of protein one-bond residual dipolar couplings without increased resonance overlap.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2005;174(2):245-53.
2005: Holger Kneuper; Ingo G Janausch; Vinesh Vijayan; Markus Zweckstetter; Verena Bock; Christian Griesinger; Gottfried Unden
The nature of the stimulus and of the fumarate binding site of the fumarate sensor DcuS of Escherichia coli.
The Journal of biological chemistry 2005;280(21):20596-603.
2005: Sigrun Rumpel; Hai-Young Kim; Vinesh Vijayan; Stefan Becker; Markus Zweckstetter
Backbone resonance assignment of the homodimeric, 35 kDa chaperone CesT from enteropathogenic Escherichia coli.
Journal of biomolecular NMR 2005;31(4):377-8.
2005: Rodolfo Maximiliano Rasia; CARLOS WALTER BERTONCINI; Derek Marsh; Wolfgang Hoyer; Dmitry Cherny; Markus Zweckstetter; Christian Griesinger; Thomas M Jovin; Claudio O Fernández
Structural characterization of copper(II) binding to alpha-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(12):4294-9.
2005: CARLOS WALTER BERTONCINI; Young-Sang Jung; Claudio O Fernandez; Wolfgang Hoyer; Christian Griesinger; Thomas M Jovin; Markus Zweckstetter
Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1430-5.
2004: Sigrun Rumpel; Adelia Razeto; Christopher M Pillar; Vinesh Vijayan; Austin Taylor; Karin Giller; Michael S Gilmore; Stefan Becker; Markus Zweckstetter
Structure and DNA-binding properties of the cytolysin regulator CylR2 from Enterococcus faecalis.
The EMBO journal 2004;23(18):3632-42.
2004: Young-Sang Jung; Markus Zweckstetter
Backbone assignment of proteins with known structure using residual dipolar couplings.
Journal of biomolecular NMR 2004;30(1):25-35.
2004: Young-Sang Jung; Markus Zweckstetter
Mars -- robust automatic backbone assignment of proteins.
Journal of biomolecular NMR 2004;30(1):11-23.
2004: Young-Sang Jung; Mukesh Sharma; Markus Zweckstetter
Simultaneous assignment and structure determination of protein backbones by using NMR dipolar couplings.
Angewandte Chemie (International ed. in English) 2004;43(26):3479-81.
2004: Markus Zweckstetter; Gerhard Hummer; Adriaan Bax
Prediction of charge-induced molecular alignment of biomolecules dissolved in dilute liquid-crystalline phases.
Biophysical journal 2004;86(6):3444-60.
2004: Claudio O Fernández; Wolfgang Hoyer; Markus Zweckstetter; Elizabeth Jares-Erijman; Vinod Subramaniam; Christian Griesinger; Thomas M Jovin
NMR of alpha-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation.
The EMBO journal 2004;23(10):2039-46.
2004: Adelia Razeto; Karin Giller; Wolfgang Haas; Michael S Gilmore; Markus Zweckstetter; Stefan Becker
Expression, purification, crystallization and preliminary crystallographic studies of the Enterococcus faecalis cytolysin repressor CylR2.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 4):746-8.
2003: Lucia Pappalardo; Ingo G Janausch; Vinesh Vijayan; Eva Zientz; Jochen Junker; Wolfgang Peti; Markus Zweckstetter; Gottfried Unden; Christian Griesinger
The NMR structure of the sensory domain of the membranous two-component fumarate sensor (histidine protein kinase) DcuS of Escherichia coli.
The Journal of biological chemistry 2003;278(40):39185-8.
2003: Markus Zweckstetter
Determination of molecular alignment tensors without backbone resonance assignment: Aid to rapid analysis of protein-protein interactions.
Journal of biomolecular NMR 2003;27(1):41-56.
2003: Laurent Verdier; Peyman Sakhaii; Markus Zweckstetter; Christian Griesinger
Measurement of long range H,C couplings in natural products in orienting media: a tool for structure elucidation of natural products.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2003;163(2):353-9.
2002: Markus Zweckstetter; Adriaan Bax
Evaluation of uncertainty in alignment tensors obtained from dipolar couplings.
Journal of biomolecular NMR 2002;23(2):127-37.
2001: Markus Zweckstetter; Adriaan Bax
Single-step determination of protein substructures using dipolar couplings: aid to structural genomics.
Journal of the American Chemical Society 2001;123(38):9490-1.
2001: Markus Zweckstetter; Adriaan Bax
Characterization of molecular alignment in aqueous suspensions of Pf1 bacteriophage.
Journal of biomolecular NMR 2001;20(4):365-77.