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Michael Zwick

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HIV-1

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TOP 3
Daniel P Leaman; Michael B Zwick
Increased functional stability and homogeneity of viral envelope spikes through directed evolution.
Robyn L Stanfield; Johannes Gach; Jean-Philippe Julien; Robert Pejchal; Michael B Zwick; Ian A Wilson
Structure-based design of a protein immunogen that displays an HIV-1 gp41 neutralizing epitope.
Johannes Gach; Daniel P Leaman; Michael B Zwick
Targeting HIV-1 gp41 in close proximity to the membrane using antibody and other molecules.

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All Publications

2013: Daniel P Leaman; Michael B Zwick
Increased functional stability and homogeneity of viral envelope spikes through directed evolution.
PLoS pathogens 2013;9(2):e1003184.
2011: Robyn L Stanfield; Johannes Gach; Jean-Philippe Julien; Robert Pejchal; Michael B Zwick; Ian A Wilson
Structure-based design of a protein immunogen that displays an HIV-1 gp41 neutralizing epitope.
Journal of molecular biology 2011;414(3):460-76.
2011: Johannes Gach; Daniel P Leaman; Michael B Zwick
Targeting HIV-1 gp41 in close proximity to the membrane using antibody and other molecules.
Current topics in medicinal chemistry 2011;11(24):2997-3021.
2009: Robert Pejchal; Johannes Gach; Florence Brunel; Rosa M F Cardoso; Robyn L Stanfield; Philip E Dawson; Dennis R Burton; Michael B Zwick; Ian A Wilson
A conformational switch in human immunodeficiency virus gp41 revealed by the structures of overlapping epitopes recognized by neutralizing antibodies.
Journal of virology 2009;83(17):8451-62.
2008: Emma T Crooks; Pengfei Jiang; Michael Franti; Sharon Wong; Michael B Zwick; James A Hoxie; James E Robinson; Penny L Moore; James M Binley
Relationship of HIV-1 and SIV envelope glycoprotein trimer occupation and neutralization.
Virology 2008;377(2):364-78.
2008: Josh D Nelson; Heather Kinkead; Florence Brunel; Dan Leaman; Richard Jensen; John M Louis; Toshiaki Maruyama; Carole A Bewley; Katherine Bowdish; G Marius Clore; Philip E Dawson; Shana Frederickson; Rose G Mage; Douglas D Richman; Dennis R Burton; Michael B Zwick
Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics.
Virology 2008;377(1):170-83.
2007: Michael B Zwick; Dennis R Burton
HIV-1 neutralization: mechanisms and relevance to vaccine design.
Current HIV research 2007;5(6):608-24.
2007: Erin M Scherer; Michael B Zwick; Luc Teyton; Dennis R Burton
Difficulties in eliciting broadly neutralizing anti-HIV antibodies are not explained by cardiolipin autoreactivity.
AIDS (London, England) 2007;21(16):2131-9.
2007: Erica Ollmann Saphire; Marinieve Montero; Alfredo Menendez; Nienke E van Houten; Melita B Irving; Ralph Pantophlet; Michael B Zwick; Paul W H I Parren; Dennis R Burton; jamie scott; Ian A Wilson
Structure of a high-affinity "mimotope" peptide bound to HIV-1-neutralizing antibody b12 explains its inability to elicit gp120 cross-reactive antibodies.
Journal of molecular biology 2007;369(3):696-709.
2007: Josh D Nelson; Florence Brunel; Richard Jensen; Emma T Crooks; Rosa M F Cardoso; Meng Wang; Ann J Hessell; Ian A Wilson; James M Binley; Philip E Dawson; Dennis R Burton; Michael B Zwick
An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10.
Journal of virology 2007;81(8):4033-43.
2007: Tongqing Zhou; Ling Xu; Barna Dey; Ann J Hessell; Donald Van Ryk; Shi-Hua Xiang; Xinzhen Yang; Mei-Yun Zhang; Michael B Zwick; James Arthos; Dennis R Burton; Dimiter S Dimitrov; Joseph Sodroski; Richard Wyatt; Gary Nabel; Peter D Kwong
Structural definition of a conserved neutralization epitope on HIV-1 gp120.
Nature 2007;445(7129):732-7.
2007: Rosa M F Cardoso; Florence Brunel; Sharon Ferguson; Michael B Zwick; Dennis R Burton; Philip E Dawson; Ian A Wilson
Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10.
Journal of molecular biology 2007;365(5):1533-44.
2007: D R Bowley; Aran F Labrijn; Michael B Zwick; Dennis R Burton
Antigen selection from an HIV-1 immune antibody library displayed on yeast yields many novel antibodies compared to selection from the same library displayed on phage.
Protein engineering, design & selection : PEDS 2007;20(2):81-90.
2006: N E van Houten; Michael B Zwick; Alfredo Menendez; jamie scott
Filamentous phage as an immunogenic carrier to elicit focused antibody responses against a synthetic peptide.
Vaccine 2006;24(19):4188-200.
2006: Penny L Moore; Emma T Crooks; Lauren Porter; Ping Zhu; Charmagne S Cayanan; Henry Grise; Paul corcoran; Michael B Zwick; Michael Franti; Lynn Morris; Kenneth H Roux; Dennis R Burton; James M Binley
Nature of nonfunctional envelope proteins on the surface of human immunodeficiency virus type 1.
Journal of virology 2006;80(5):2515-28.
2006: Florence Brunel; Michael B Zwick; Rosa M F Cardoso; Josh D Nelson; Ian A Wilson; Dennis R Burton; Philip E Dawson
Structure-function analysis of the epitope for 4E10, a broadly neutralizing human immunodeficiency virus type 1 antibody.
Journal of virology 2006;80(4):1680-7.
2005: Rosa M F Cardoso; Michael B Zwick; Robyn L Stanfield; Renate Kunert; James M Binley; Hermann Katinger; Dennis R Burton; Ian A Wilson
Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41.
Immunity 2005;22(2):163-73.
2005: Michael B Zwick; Richard Jensen; Sarah Church; Meng Wang; Gabriela Stiegler; Renate Kunert; Hermann Katinger; Dennis R Burton
Anti-human immunodeficiency virus type 1 (HIV-1) antibodies 2F5 and 4E10 require surprisingly few crucial residues in the membrane-proximal external region of glycoprotein gp41 to neutralize HIV-1.
Journal of virology 2005;79(2):1252-61.
2004: James M Binley; Terri Wrin; Bette Korber; Michael B Zwick; Meng Wang; Colombe Chappey; Gabriela Stiegler; Renate Kunert; Susan Zolla-Pazner; Hermann Katinger; Christos J Petropoulos; Dennis R Burton
Comprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodies.
Journal of virology 2004;78(23):13232-52.
2004: Mei-Yun Zhang; Xiaodong Xiao; Igor A Sidorov; Vidita Choudhry; Fatim Cham; Peng Fei Zhang; Peter Bouma; Michael B Zwick; Anil Choudhary; David C Montefiori; Christopher C Broder; Dennis R Burton; Gerald V Quinnan; Dimiter S Dimitrov
Identification and characterization of a new cross-reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody.
Journal of virology 2004;78(17):9233-42.
2004: Michael B Zwick; H Kiyomi Komori; Robyn L Stanfield; Sarah Church; Meng Wang; Paul W H I Parren; Renate Kunert; Hermann Katinger; Ian A Wilson; Dennis R Burton
The long third complementarity-determining region of the heavy chain is important in the activity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5.
Journal of virology 2004;78(6):3155-61.
2004: Michael B Zwick; Erica Ollmann Saphire; Dennis R Burton
gp41: HIV's shy protein.
Nature medicine 2004;10(2):133-4.
2004: Mei-Yun Zhang; Yuuei Shu; Donna Rudolph; Prabakaran Ponraj; Aran F Labrijn; Michael B Zwick; Renu B Lal; Dimiter S Dimitrov
Improved breadth and potency of an HIV-1-neutralizing human single-chain antibody by random mutagenesis and sequential antigen panning.
Journal of molecular biology 2004;335(1):209-19.
2003: Aran F Labrijn; Pascal Poignard; Aarti Raja; Michael B Zwick; Karla Delgado; Michael Franti; James M Binley; Veronique Vivona; Christoph Grundner; Chih-Chin Huang; Miro Venturi; Christos J Petropoulos; Terri Wrin; Dimiter S Dimitrov; James Robinson; Peter D Kwong; Richard Wyatt; Joseph Sodroski; Dennis R Burton
Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1.
Journal of virology 2003;77(19):10557-65.
2003: Hyeryun Choe; Wenhui Li; Paulette L Wright; Natalya Vasilieva; Miro Venturi; Chih-Chin Huang; Christoph Grundner; Tatyana Dorfman; Michael B Zwick; Liping Wang; Eric S Rosenberg; Peter D Kwong; Dennis R Burton; James E Robinson; Joseph Sodroski; Michael Farzan
Tyrosine sulfation of human antibodies contributes to recognition of the CCR5 binding region of HIV-1 gp120.
Cell 2003;114(2):161-70.
2003: Daniel A Calarese; Christopher N Scanlan; Michael B Zwick; Songpon Deechongkit; Yusuke Mimura; Renate Kunert; Ping Zhu; Mark R Wormald; Robyn L Stanfield; Kenneth H Roux; Jeffery W Kelly; Pauline M Rudd; Raymond A Dwek; Hermann Katinger; Dennis R Burton; Ian A Wilson
Antibody domain exchange is an immunological solution to carbohydrate cluster recognition.
Science (New York, N.Y.) 2003;300(5628):2065-71.
2003: Michael B Zwick; Robert Kelleher; Richard Jensen; Aran F Labrijn; Meng Wang; Gerald V Quinnan; Paul W H I Parren; Dennis R Burton
A novel human antibody against human immunodeficiency virus type 1 gp120 is V1, V2, and V3 loop dependent and helps delimit the epitope of the broadly neutralizing antibody immunoglobulin G1 b12.
Journal of virology 2003;77(12):6965-78.
2003: Michael B Zwick; Paul W H I Parren; Erica Ollmann Saphire; Sarah Church; Meng Wang; jamie scott; Philip E Dawson; Ian A Wilson; Dennis R Burton
Molecular features of the broadly neutralizing immunoglobulin G1 b12 required for recognition of human immunodeficiency virus type 1 gp120.
Journal of virology 2003;77(10):5863-76.
2003: Erica Ollmann Saphire; Robyn L Stanfield; Max Crispin; Garrett Morris; Michael B Zwick; Ralph Pantophlet; Paul W H I Parren; Pauline M Rudd; Raymond A Dwek; Dennis R Burton; Ian A Wilson
Crystal structure of an intact human IgG: antibody asymmetry, flexibility, and a guide for HIV-1 vaccine design.
Advances in experimental medicine and biology 2003;535():55-66.
2001: Michael B Zwick; Meng Wang; Pascal Poignard; Gabriela Stiegler; Hermann Katinger; Dennis R Burton; Paul W H I Parren
Neutralization synergy of human immunodeficiency virus type 1 primary isolates by cocktails of broadly neutralizing antibodies.
Journal of virology 2001;75(24):12198-208.
2001: Michael B Zwick; Aran F Labrijn; Meng Wang; C Spenlehauer; Erica Ollmann Saphire; James M Binley; John P Moore; Gabriela Stiegler; Hermann Katinger; Dennis R Burton; Paul W H I Parren
Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41.
Journal of virology 2001;75(22):10892-905.
2001: Erica Ollmann Saphire; Paul W H I Parren; Ralph Pantophlet; Michael B Zwick; G M Morris; Pauline M Rudd; Raymond A Dwek; Robyn L Stanfield; Dennis R Burton; Ian A Wilson
Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design.
Science (New York, N.Y.) 2001;293(5532):1155-9.
2001: Michael B Zwick; LL Bonnycastle; Alfredo Menendez; M B Irving; C F Barbas; Paul W H I Parren; Dennis R Burton; jamie scott
Identification and characterization of a peptide that specifically binds the human, broadly neutralizing anti-human immunodeficiency virus type 1 antibody b12.
Journal of virology 2001;75(14):6692-9.
2000: Michael B Zwick; J Shen; jamie scott
Homodimeric peptides displayed by the major coat protein of filamentous phage.
Journal of molecular biology 2000;300(2):307-20.
1998: Michael B Zwick; LL Bonnycastle; K A Noren; S Venturini; E Leong; C F Barbas; Christopher J Noren; jamie scott
The maltose-binding protein as a scaffold for monovalent display of peptides derived from phage libraries.
Analytical biochemistry 1998;264(1):87-97.
1998: Michael B Zwick; J Shen; jamie scott
Phage-displayed peptide libraries.
Current opinion in biotechnology 1998;9(4):427-36.
1997: S L Harris; Lisa Craig; J S Mehroke; M Rashed; Michael B Zwick; K Kenar; E J Toone; N Greenspan; France-Isabelle Auzanneau; J R Marino-Albernas; B Mario Pinto; jamie scott
Exploring the basis of peptide-carbohydrate crossreactivity: evidence for discrimination by peptides between closely related anti-carbohydrate antibodies.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2454-9.