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Thomas Brown

Research Profile

Living Beings

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Bone Diseases, Metabolic

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TOP 3
Leonard Buckbinder; D Todd Crawford; Hong Qi; Hua Zhu Ke; Lisa M Olson; Kelly R Long; Peter C Bonnette; Amy P Baumann; John E Hambor; William A Grasser; Lydia C Pan; Thomas A Owen; Michael J Luzzio; Catherine A Hulford; David F Gebhard; Vishwas M Paralkar; Hollis A Simmons; John C Kath; W Gregory Roberts; Steven L Smock; Angel Guzman-Perez; Thomas Brown; Mei Li
Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis.
Thomas Brown
Vitamin D analogs as anabolic agents.
Mei Li; Lydia C Pan; Hollis A Simmons; Yan Li; David R Healy; B S Robinson; Hua Zhu Ke; Thomas Brown
Surface-specific effects of a PPARgamma agonist, darglitazone, on bone in mice.

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All Publications

2007: Leonard Buckbinder; D Todd Crawford; Hong Qi; Hua Zhu Ke; Lisa M Olson; Kelly R Long; Peter C Bonnette; Amy P Baumann; John E Hambor; William A Grasser; Lydia C Pan; Thomas A Owen; Michael J Luzzio; Catherine A Hulford; David F Gebhard; Vishwas M Paralkar; Hollis A Simmons; John C Kath; W Gregory Roberts; Steven L Smock; Angel Guzman-Perez; Thomas Brown; Mei Li
Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(25):10619-24.
2006: Thomas Brown
Vitamin D analogs as anabolic agents.
Journal of musculoskeletal & neuronal interactions 2006;6(4):341-3.
2006: Mei Li; Lydia C Pan; Hollis A Simmons; Yan Li; David R Healy; B S Robinson; Hua Zhu Ke; Thomas Brown
Surface-specific effects of a PPARgamma agonist, darglitazone, on bone in mice.
Bone 2006;39(4):796-806.
2006: Hua Zhu Ke; D Todd Crawford; Hong Qi; Hollis A Simmons; Thomas A Owen; Vishwas M Paralkar; Mei Li; Bihong Lu; William A Grasser; Kimberly O Cameron; Bruce A Lefker; Paul DaSilva-Jardine; Dennis O Scott; Qing Zhang; Xiao Yan Tian; Webster S S Jee; Thomas Brown; David D Thompson
A nonprostanoid EP4 receptor selective prostaglandin E2 agonist restores bone mass and strength in aged, ovariectomized rats.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006;21(4):565-75.
2005: Richard Chesworth; Matthew D Wessel; Lisa Heyden; F Michael Mangano; Michael P Zawistoski; Laura Gegnas; David Galluzzo; Bruce A Lefker; Kimberly O Cameron; Jeanne Tickner; Bihong Lu; Tessa A Castleberry; Donna N Petersen; Amy Brault; Pia Perry; Oicheng Ng; Thomas A Owen; Lydia Pan; Hua Zhu Ke; Thomas Brown; David D Thompson; Paul DaSilva-Jardine
Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands.
Bioorganic & medicinal chemistry letters 2005;15(24):5562-6.
2005: Hua Zhu Ke; Hong Qi; D Todd Crawford; Hollis A Simmons; Gang Xu; Mei Li; Lori A Plum; Margaret Clagett-Dame; Hector F Deluca; David D Thompson; Thomas Brown
A new vitamin D analog, 2MD, restores trabecular and cortical bone mass and strength in ovariectomized rats with established osteopenia.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005;20(10):1742-55.
2005: Mei Li; David R Healy; Yan Li; Hollis A Simmons; D Todd Crawford; Hua Zhu Ke; Lydia C Pan; Thomas Brown; David D Thompson
Osteopenia and impaired fracture healing in aged EP4 receptor knockout mice.
Bone 2005;37(1):46-54.
2005: Shiguang Liu; Thomas Brown; Jianping Zhou; Zhou-Sheng Xiao; Hani Awad; Farshid Guilak; L Darryl Quarles
Role of matrix extracellular phosphoglycoprotein in the pathogenesis of X-linked hypophosphatemia.
Journal of the American Society of Nephrology : JASN 2005;16(6):1645-53.
2004: Richard Chesworth; Michael P Zawistoski; Bruce A Lefker; Kimberly O Cameron; Robert F Day; F Michael Mangano; Robert L Rosati; Stacy Colella; Donna N Petersen; Amy Brault; Bihong Lu; Lydia C Pan; Pia Perry; Oicheng Ng; Tessa A Castleberry; Thomas A Owen; Thomas Brown; David D Thompson; Paul DaSilva-Jardine
Tetrahydroisoquinolines as subtype selective estrogen agonists/antagonists.
Bioorganic & medicinal chemistry letters 2004;14(11):2729-33.
2003: Mei Li; Hua Zhu Ke; Hong Qi; David R Healy; Yan Li; D Todd Crawford; Vishwas M Paralkar; Thomas A Owen; Kimberly O Cameron; Bruce A Lefker; Thomas Brown; David D Thompson
A novel, non-prostanoid EP2 receptor-selective prostaglandin E2 agonist stimulates local bone formation and enhances fracture healing.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003;18(11):2033-42.
2003: Vishwas M Paralkar; Fran Borovecki; Hua Zhu Ke; Kimberly O Cameron; Bruce A Lefker; William A Grasser; Thomas A Owen; Mei Li; Paul DaSilva-Jardine; M Zhou; R L Dunn; F Dumont; R Korsmeyer; P Krasney; Thomas Brown; D Plowchalk; Slobodan Vukicevic; David D Thompson
An EP2 receptor-selective prostaglandin E2 agonist induces bone healing.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(11):6736-40.
2003: Lori C Gowen; Donna N Petersen; Amy L Mansolf; Hong Qi; Jeffrey L Stock; George T Tkalcevic; Hollis A Simmons; D Todd Crawford; Kristin L Chidsey-Frink; Hua Zhu Ke; John McNeish; Thomas Brown
Targeted disruption of the osteoblast/osteocyte factor 45 gene (OF45) results in increased bone formation and bone mass.
The Journal of biological chemistry 2003;278(3):1998-2007.
2002: Hua Zhu Ke; Thomas Brown; Hong Qi; D Todd Crawford; Hollis A Simmons; Donna N Petersen; Melanie R Allen; John McNeish; David D Thompson
The role of estrogen receptor-beta, in the early age-related bone gain and later age-related bone loss in female mice.
Journal of musculoskeletal & neuronal interactions 2002;2(5):479-88.
2002: Rebecca L Rich; Lise R Hoth; Kieran F Geoghegan; Thomas Brown; Peter K LeMotte; Samuel P Simons; Preston Hensley; David G Myszka
Kinetic analysis of estrogen receptor/ligand interactions.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(13):8562-7.
2000: Donna N Petersen; George T Tkalcevic; Amy L Mansolf; R Rivera-Gonzalez; Thomas Brown
Identification of osteoblast/osteocyte factor 45 (OF45), a bone-specific cDNA encoding an RGD-containing protein that is highly expressed in osteoblasts and osteocytes.
The Journal of biological chemistry 2000;275(46):36172-80.
1998: Robert L Rosati; P Da Silva Jardine; Kimberly O Cameron; David D Thompson; Hua Zhu Ke; Steven M Toler; Thomas Brown; Lydia C Pan; C F Ebbinghaus; A R Reinhold; N C Elliott; B N Newhouse; C M Tjoa; P M Sweetnam; MJ Cole; M W Arriola; J W Gauthier; D Todd Crawford; David F Nickerson; Christine M Pirie; Hong Qi; Hollis A Simmons; George T Tkalcevic
Discovery and preclinical pharmacology of a novel, potent, nonsteroidal estrogen receptor agonist/antagonist, CP-336156, a diaryltetrahydronaphthalene.
Journal of medicinal chemistry 1998;41(16):2928-31.
1998: Vishwas M Paralkar; A L Vail; William A Grasser; Thomas Brown; H Xu; Slobodan Vukicevic; Hua Zhu Ke; Hong Qi; Thomas A Owen; David D Thompson
Cloning and characterization of a novel member of the transforming growth factor-beta/bone morphogenetic protein family.
The Journal of biological chemistry 1998;273(22):13760-7.
1998: Hua Zhu Ke; Vishwas M Paralkar; William A Grasser; D Todd Crawford; Hong Qi; Hollis A Simmons; Christine M Pirie; Kristin L Chidsey-Frink; Thomas A Owen; Steven L Smock; HK Chen; Webster S S Jee; Kimberly O Cameron; Robert L Rosati; Thomas Brown; Paul DaSilva-Jardine; David D Thompson
Effects of CP-336,156, a new, nonsteroidal estrogen agonist/antagonist, on bone, serum cholesterol, uterus and body composition in rat models.
Endocrinology 1998;139(4):2068-76.
1998: Donna N Petersen; George T Tkalcevic; Petra H Koza-Taylor; Tom Turi; Thomas Brown
Identification of estrogen receptor beta2, a functional variant of estrogen receptor beta expressed in normal rat tissues.
Endocrinology 1998;139(3):1082-92.
1998: R Rivera-Gonzalez; Donna N Petersen; George T Tkalcevic; David D Thompson; Thomas Brown
Estrogen-induced genes in the uterus of ovariectomized rats and their regulation by droloxifene and tamoxifen.
The Journal of steroid biochemistry and molecular biology 1998;64(1-2):13-24.