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Xian-Ming Chen

Research Profile

Anatomy

Disorders

Cryptosporidiosis

Chemicals & Drugs

Phenomena

Host-Parasite Interactions

Physiology

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Microscopy, Immunoelectron

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Publications

TOP 3
Guoku Hu; Bing Q Huang; Nicholas F LaRusso; Amanda L Roth; Honorine D Ward; Guan Zhu; Ai-Yu Gong; Nancy D Hanson; Xian-Ming Chen
Release of Luminal Exosomes Contributes to TLR4-Mediated Epithelial Antimicrobial Defense.
Jing Xiao; Charles Y F Young; Dongqing Chen; Caishu Deng; Alex N Eischeid; Ai-Yu Gong; Xian-Ming Chen
miR-141 modulates androgen receptor transcriptional activity in human prostate cancer cells through targeting the small heterodimer partner protein.
Jun Liu; Alex N Eischeid; Xian-Ming Chen
Col1A1 production and apoptotic resistance in TGF-β1-induced epithelial-to-mesenchymal transition-like phenotype of 603B cells.

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All Publications

2013: Guoku Hu; Bing Q Huang; Nicholas F LaRusso; Amanda L Roth; Honorine D Ward; Guan Zhu; Ai-Yu Gong; Nancy D Hanson; Xian-Ming Chen
Release of Luminal Exosomes Contributes to TLR4-Mediated Epithelial Antimicrobial Defense.
PLoS pathogens 2013;9(4):e1003261.
2012: Jing Xiao; Charles Y F Young; Dongqing Chen; Caishu Deng; Alex N Eischeid; Ai-Yu Gong; Xian-Ming Chen
miR-141 modulates androgen receptor transcriptional activity in human prostate cancer cells through targeting the small heterodimer partner protein.
The Prostate 2012;72(14):1514-22.
2012: Jun Liu; Alex N Eischeid; Xian-Ming Chen
Col1A1 production and apoptotic resistance in TGF-β1-induced epithelial-to-mesenchymal transition-like phenotype of 603B cells.
PloS one 2012;7(12):e51371.
2012: Ai-Yu Gong; Zhao-Yi Wang; Jing Xiao; Charles Yf Young; Jian Zhao; Dongqing Chen; Alex N Eischeid; Xian-Ming Chen
miR-17-5p targets the p300/CBP-associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells.
BMC cancer 2012;12():492.
2012: Rui Zhou; Alex N Eischeid; Ai-Yu Gong; Xian-Ming Chen
miR-27b targets KSRP to coordinate TLR4-mediated epithelial defense against Cryptosporidium parvum infection.
PLoS pathogens 2012;8(5):e1002702.
2012: Guoku Hu; Kristen M Drescher; Xian-Ming Chen
Exosomal miRNAs: Biological Properties and Therapeutic Potential.
Frontiers in genetics 2012;3():56.
2012: Rui Zhou; Kristen M Drescher; Ai-Yu Gong; Guoku Hu; Xiaoqing Li; Xian-Ming Chen
miR-16 targets transcriptional corepressor SMRT and modulates NF-kappaB-regulated transactivation of interleukin-8 gene.
PloS one 2012;7(1):e30772.
2011: Steven P O'Hara; Xian-Ming Chen
The cell biology of cryptosporidium infection.
Microbes and infection / Institut Pasteur 2011;13(8-9):721-30.
2011: Ai-Yu Gong; Guoku Hu; Rui Zhou; Jun Liu; Yaoyu Feng; Garrett A Soukup; Xian-Ming Chen
MicroRNA-221 controls expression of intercellular adhesion molecule-1 in epithelial cells in response to Cryptosporidium parvum infection.
International journal for parasitology 2011;41(3-4):397-403.
2010: Guoku Hu; Rui Zhou; Jun Liu; Ai-Yu Gong; Xian-Ming Chen
MicroRNA-98 and let-7 regulate expression of suppressor of cytokine signaling 4 in biliary epithelial cells in response to Cryptosporidium parvum infection.
The Journal of infectious diseases 2010;202(1):125-35.
2010: Rui Zhou; Guoku Hu; Ai-Yu Gong; Xian-Ming Chen
Binding of NF-kappaB p65 subunit to the promoter elements is involved in LPS-induced transactivation of miRNA genes in human biliary epithelial cells.
Nucleic acids research 2010;38(10):3222-32.
2010: Guoku Hu; Ai-Yu Gong; Jun Liu; Rui Zhou; Caishu Deng; Xian-Ming Chen
miR-221 suppresses ICAM-1 translation and regulates interferon-gamma-induced ICAM-1 expression in human cholangiocytes.
American journal of physiology. Gastrointestinal and liver physiology 2010;298(4):G542-50.
2010: Ai-Yu Gong; Rui Zhou; Guoku Hu; Jun Liu; Danuta Sosnowska; Kristen Drescher; Haidong Dong; Xian-Ming Chen
Cryptosporidium parvum induces B7-H1 expression in cholangiocytes by down-regulating microRNA-513.
The Journal of infectious diseases 2010;201(1):160-9.
2010: Steven P O'Hara; Patrick L Splinter; Gabriella B Gajdos; Christy E Trussoni; Martin E Fernandez Zapico; Xian-Ming Chen; Nicholas F LaRusso
NFkappaB p50-CCAAT/enhancer-binding protein beta (C/EBPbeta)-mediated transcriptional repression of microRNA let-7i following microbial infection.
The Journal of biological chemistry 2010;285(1):216-25.
2009: Rui Zhou; Guoku Hu; Jun Liu; Ai-Yu Gong; Kristen Drescher; Xian-Ming Chen
NF-kappaB p65-dependent transactivation of miRNA genes following Cryptosporidium parvum infection stimulates epithelial cell immune responses.
PLoS pathogens 2009;5(12):e1000681.
2009: Guoku Hu; Rui Zhou; Jun Liu; Ai-Yu Gong; Alex N Eischeid; Jared W Dittman; Xian-Ming Chen
MicroRNA-98 and let-7 confer cholangiocyte expression of cytokine-inducible Src homology 2-containing protein in response to microbial challenge.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(3):1617-24.
2009: Steven P O'Hara; Aaron J Small; Gabriella B Gajdos; andrew badley; Xian-Ming Chen; Nicholas F LaRusso
HIV-1 Tat protein suppresses cholangiocyte toll-like receptor 4 expression and defense against Cryptosporidium parvum.
The Journal of infectious diseases 2009;199(8):1195-204.
2009: Ai-Yu Gong; Rui Zhou; Guoku Hu; Xiaoqing Li; Patrick L Splinter; Steven P O'Hara; Nicholas F LaRusso; garrett soukup; Haidong Dong; Xian-Ming Chen
MicroRNA-513 regulates B7-H1 translation and is involved in IFN-gamma-induced B7-H1 expression in cholangiocytes.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(3):1325-33.
2009: Jun Liu; Kristen Drescher; Xian-Ming Chen
MicroRNAs and Epithelial Immunity.
International reviews of immunology 2009;28(3-4):139-54.
2008: Nuo Yang; Sippy Kaur; Stefano Volinia; Joel Greshock; Heini Lassus; Kosei Hasegawa; Shun Liang; Arto Leminen; Shan Deng; Lori Smith; Cameron N Johnstone; Xian-Ming Chen; Chang-Gong Liu; Qihong Huang; Dionyssios Katsaros; George Adrian Calin; Barbara L Weber; Ralf Bützow; Carlo M Croce; George Coukos; Lin Zhang
MicroRNA microarray identifies Let-7i as a novel biomarker and therapeutic target in human epithelial ovarian cancer.
Cancer research 2008;68(24):10307-14.
2008: Xian-Ming Chen; Steven P O'Hara; Nicholas F LaRusso
The immunobiology of cholangiocytes.
Immunology and cell biology 2008;86(6):497-505.
2008: Steven P O'Hara; Aaron J Small; Xian-Ming Chen; Nicholas F LaRusso
Host cell actin remodeling in response to Cryptosporidium.
Sub-cellular biochemistry 2008;47():92-100.
2007: Xian-Ming Chen; Patrick L Splinter; Steven P O'Hara; Nicholas F LaRusso
A cellular micro-RNA, let-7i, regulates Toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection.
The Journal of biological chemistry 2007;282(39):28929-38.
2007: Hui-Ying Zhang; De-wu Han; Zhong-fu Zhao; Ming-she Liu; Yan-Jun Wu; Xian-Ming Chen; Cheng Ji
Multiple pathogenic factor-induced complications of cirrhosis in rats: a new model of hepatopulmonary syndrome with intestinal endotoxemia.
World journal of gastroenterology : WJG 2007;13(25):3500-7.
2007: Steven P O'Hara; Aaron J Small; Jeremy B Nelson; andrew badley; Xian-Ming Chen; Gregory J Gores; Nicholas F LaRusso
The human immunodeficiency virus type 1 tat protein enhances Cryptosporidium parvum-induced apoptosis in cholangiocytes via a Fas ligand-dependent mechanism.
Infection and immunity 2007;75(2):684-96.
2006: Jeremy B Nelson; Steven P O'Hara; Aaron J Small; Pamela S Tietz; Amit Choudhury; Richard E Pagano; Xian-Ming Chen; Nicholas F LaRusso
Cryptosporidium parvum infects human cholangiocytes via sphingolipid-enriched membrane microdomains.
Cellular microbiology 2006;8(12):1932-45.
2005: Xian-Ming Chen; Steven P O'Hara; Jeremy B Nelson; Patrick L Splinter; Aaron J Small; Pamela S Tietz; Andrew H Limper; Nicholas F LaRusso
Multiple TLRs are expressed in human cholangiocytes and mediate host epithelial defense responses to Cryptosporidium parvum via activation of NF-kappaB.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(11):7447-56.
2005: Steven P O'Hara; Bing Q Huang; Xian-Ming Chen; Jeremy Nelson; Nicholas F LaRusso
Distribution of Cryptosporidium parvum sporozoite apical organelles during attachment to and internalization by cultured biliary epithelial cells.
The Journal of parasitology 2005;91(5):995-9.
2005: Xian-Ming Chen; Steven P O'Hara; Bing Q Huang; Patrick L Splinter; Jeremy B Nelson; Nicholas F LaRusso
Localized glucose and water influx facilitates Cryptosporidium parvum cellular invasion by means of modulation of host-cell membrane protrusion.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(18):6338-43.
2004: Xian-Ming Chen; Steven P O'Hara; Bing Q Huang; Jeremy B Nelson; Jim Jung-Ching Lin; Guan Zhu; Honorine D Ward; Nicholas F LaRusso
Apical organelle discharge by Cryptosporidium parvum is temperature, cytoskeleton, and intracellular calcium dependent and required for host cell invasion.
Infection and immunity 2004;72(12):6806-16.
2004: Xian-Ming Chen; Patrick L Splinter; Pamela S Tietz; Bing Q Huang; Daniel D Billadeau; Nicholas F LaRusso
Phosphatidylinositol 3-kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42.
The Journal of biological chemistry 2004;279(30):31671-8.
2004: Xian-Ming Chen; Bing Q Huang; Patrick L Splinter; James Orth; Daniel D Billadeau; Mark A McNiven; Nicholas F LaRusso
Cdc42 and the actin-related protein/neural Wiskott-Aldrich syndrome protein network mediate cellular invasion by Cryptosporidium parvum.
Infection and immunity 2004;72(5):3011-21.
2004: Bing Q Huang; Xian-Ming Chen; Nicholas F LaRusso
Cryptosporidium parvum attachment to and internalization by human biliary epithelia in vitro: a morphologic study.
The Journal of parasitology 2004;90(2):212-21.
2003: Xian-Ming Chen; Bing Q Huang; Patrick L Splinter; Hong Cao; Guan Zhu; Mark A McNiven; Nicholas F LaRusso
Cryptosporidium parvum invasion of biliary epithelia requires host cell tyrosine phosphorylation of cortactin via c-Src.
Gastroenterology 2003;125(1):216-28.
2003: Pamela S Tietz; Raúl A Marinelli; Xian-Ming Chen; Bing Huang; Jonathan Cohn; Jolanta Kole; Mark A McNiven; Seth Alper; Nicholas F LaRusso
Agonist-induced coordinated trafficking of functionally related transport proteins for water and ions in cholangiocytes.
The Journal of biological chemistry 2003;278(22):20413-9.
2003: Ai-Yu Gong; Pamela S Tietz; Melissa A Muff; Patrick L Splinter; Robert C Huebert; Mathias Z Strowski; Xian-Ming Chen; Nicholas F LaRusso
Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on cholangiocytes.
American journal of physiology. Cell physiology 2003;284(5):C1205-14.
2002: Xian-Ming Chen; Nicholas F LaRusso
Cryptosporidiosis and the pathogenesis of AIDS-cholangiopathy.
Seminars in liver disease 2002;22(3):277-89.
2002: Xian-Ming Chen; Janet S Keithly; Carlos V Paya; Nicholas F LaRusso
Cryptosporidiosis.
The New England journal of medicine 2002;346(22):1723-31.
2002: Pamela S Tietz; Xian-Ming Chen; Ai-Yu Gong; Robert C Huebert; Anatoliy I Masyuk; Tatyana V Masyuk; Patrick L Splinter; Nicholas F LaRusso
Experimental models to study cholangiocyte biology.
World journal of gastroenterology : WJG 2002;8(1):1-4.
2001: Xian-Ming Chen; S A Levine; Patrick L Splinter; Pamela S Tietz; A L Ganong; Christian Jobin; Gregory J Gores; Carlos V Paya; Nicholas F LaRusso
Cryptosporidium parvum activates nuclear factor kappaB in biliary epithelia preventing epithelial cell apoptosis.
Gastroenterology 2001;120(7):1774-83.
2000: Xian-Ming Chen; Nicholas F LaRusso
Mechanisms of attachment and internalization of Cryptosporidium parvum to biliary and intestinal epithelial cells.
Gastroenterology 2000;118(2):368-79.
1999: Xian-Ming Chen; Gregory J Gores; Carlos V Paya; Nicholas F LaRusso
Cryptosporidium parvum induces apoptosis in biliary epithelia by a Fas/Fas ligand-dependent mechanism.
The American journal of physiology 1999;277(3 Pt 1):G599-608.
1998: Xian-Ming Chen; S A Levine; Pamela S Tietz; Eugene W Krueger; Mark A McNiven; D M Jefferson; M Mahle; Nicholas F LaRusso
Cryptosporidium parvum is cytopathic for cultured human biliary epithelia via an apoptotic mechanism.
Hepatology (Baltimore, Md.) 1998;28(4):906-13.