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Jason Pickens

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Chemicals & Drugs

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Rongshi Li; Liquan Xue; Tong Zhu; Qin Jiang; Xiaoli Cui; Zheng Yan; Danny McGee; Jian Wang; Vidyasagar Reddy Gantla; Jason Pickens; Doug McGrath; Alexander Chucholowski; Stephan W Morris; Thomas R Webb
Design and synthesis of 5-aryl-pyridone-carboxamides as inhibitors of anaplastic lymphoma kinase.
Erkang Fan; Claire J O'Neal; Daniel D Mitchell; Mark A Robien; Zhongsheng Zhang; Jason Pickens; Xiao-Jian Tan; Konstantin Korotkov; Claudia Roach; Brian Krumm; Christophe Verlinde; Ethan A Merritt; Wim G J Hol
Structural biology and structure-based inhibitor design of cholera toxin and heat-labile enterotoxin.
Jason Pickens; Daniel D Mitchell; Jiyun Liu; Xiaojian Tan; Zhongsheng Zhang; Christophe Verlinde; Wim G J Hol; Erkang Fan
Nonspanning bivalent ligands as improved surface receptor binding inhibitors of the cholera toxin B pentamer.

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All Publications

2006: Rongshi Li; Liquan Xue; Tong Zhu; Qin Jiang; Xiaoli Cui; Zheng Yan; Danny McGee; Jian Wang; Vidyasagar Reddy Gantla; Jason Pickens; Doug McGrath; Alexander Chucholowski; Stephan W Morris; Thomas R Webb
Design and synthesis of 5-aryl-pyridone-carboxamides as inhibitors of anaplastic lymphoma kinase.
Journal of medicinal chemistry 2006;49(3):1006-15.
2004: Erkang Fan; Claire J O'Neal; Daniel D Mitchell; Mark A Robien; Zhongsheng Zhang; Jason Pickens; Xiao-Jian Tan; Konstantin Korotkov; Claudia Roach; Brian Krumm; Christophe Verlinde; Ethan A Merritt; Wim G J Hol
Structural biology and structure-based inhibitor design of cholera toxin and heat-labile enterotoxin.
International journal of medical microbiology : IJMM 2004;294(4):217-23.
2004: Jason Pickens; Daniel D Mitchell; Jiyun Liu; Xiaojian Tan; Zhongsheng Zhang; Christophe Verlinde; Wim G J Hol; Erkang Fan
Nonspanning bivalent ligands as improved surface receptor binding inhibitors of the cholera toxin B pentamer.
Chemistry & biology 2004;11(9):1205-15.
2004: Zhongsheng Zhang; Jason Pickens; Wim G J Hol; Erkang Fan
Solution- and solid-phase syntheses of guanidine-bridged, water-soluble linkers for multivalent ligand design.
Organic letters 2004;6(9):1377-80.
2004: Daniel D Mitchell; Jason Pickens; Konstantin Korotkov; Erkang Fan; Wim G J Hol
3,5-Substituted phenyl galactosides as leads in designing effective cholera toxin antagonists; synthesis and crystallographic studies.
Bioorganic & medicinal chemistry 2004;12(5):907-20.
2002: Ethan A Merritt; Zhongsheng Zhang; Jason Pickens; Misol Ahn; Wim G J Hol; Erkang Fan
Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and E. coli heat-labile enterotoxin.
Journal of the American Chemical Society 2002;124(30):8818-24.
2002: Jason Pickens; Ethan A Merritt; Misol Ahn; Christophe Verlinde; Wim G J Hol; Erkang Fan
Anchor-based design of improved cholera toxin and E. coli heat-labile enterotoxin receptor binding antagonists that display multiple binding modes.
Chemistry & biology 2002;9(2):215-24.
2001: Erkang Fan; Ethan A Merritt; Zhongsheng Zhang; Jason Pickens; Claudia Roach; Misol Ahn; Wim G J Hol
Exploration of the GM1 receptor-binding site of heat-labile enterotoxin and cholera toxin by phenyl-ring-containing galactose derivatives.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 2):201-12.
2000: WE Minke; Jason Pickens; Ethan A Merritt; Erkang Fan; Christophe Verlinde; Wim G J Hol
Structure of m-carboxyphenyl-alpha-D-galactopyranoside complexed to heat-labile enterotoxin at 1.3 A resolution: surprising variations in ligand-binding modes.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 7):795-804.