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Bennett Van Houten

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Physiology

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Craig D Hughes; Harshad Ghodke; Ye Peng; Michelle Simons; Atif Towheed; Bennett Van Houten; Hong Wang; Neil M Kad
Real-time single-molecule imaging reveals a direct interaction between UvrC and UvrB on DNA tightropes.
Stephen Godin; Faiz Kabbinavar; Bennett Van Houten; Andrew P VanDemark; Adam Wier; Dominique S Bratton-Palmer; Harshad Ghodke; Kara A Bernstein
The Shu complex interacts with Rad51 through the Rad51 paralogues Rad55-Rad57 to mediate error-free recombination.
Caroline Kisker; Jochen Kuper; Bennett Van Houten
Prokaryotic nucleotide excision repair.

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2013: Craig D Hughes; Harshad Ghodke; Ye Peng; Michelle Simons; Atif Towheed; Bennett Van Houten; Hong Wang; Neil M Kad
Real-time single-molecule imaging reveals a direct interaction between UvrC and UvrB on DNA tightropes.
Nucleic acids research 2013;41(9):4901-12.
2013: Stephen Godin; Faiz Kabbinavar; Bennett Van Houten; Andrew P VanDemark; Adam Wier; Dominique S Bratton-Palmer; Harshad Ghodke; Kara A Bernstein
The Shu complex interacts with Rad51 through the Rad51 paralogues Rad55-Rad57 to mediate error-free recombination.
Nucleic acids research 2013;41(8):4525-34.
2013: Caroline Kisker; Jochen Kuper; Bennett Van Houten
Prokaryotic nucleotide excision repair.
Cold Spring Harbor perspectives in biology 2013;5(3):a012591.
2012: Hye-Youn Cho; Jennifer Fostel; Wesley Gladwell; Lester Kobzik; Laura Miller-DeGraff; Vijayalakshmi Panduri; Ligon Perrow; Bennett Van Houten; Xuting Wang; Masayuki Yamamoto; Douglas A Bell; Steven R Kleeberger
Targeted deletion of nrf2 impairs lung development and oxidant injury in neonatal mice.
Antioxidants & redox signaling 2012;17(8):1066-82.
2012: Heide M Roth; Verena Grundler; Caroline Kisker; Johannes Römer; Bennett Van Houten; Ingrid Tessmer
XPB helicase regulates DNA incision by the Thermoplasma acidophilum endonuclease Bax1.
DNA repair 2012;11(3):286-93.
2011: Yang Liu; Dara Reeves; Bennett Van Houten; Alexander Kolbanovskiy; Marina Kolbanovskiy; Konstantin Kropachev; Judy L Bolton; Suse Broyde; Yuqin Cai; Shuang Ding; Nicholas E Geacintov
Probing for DNA damage with β-hairpins: similarities in incision efficiencies of bulky DNA adducts by prokaryotic and human nucleotide excision repair systems in vitro.
DNA repair 2011;10(7):684-96.
2010: Miriam Sander; Thomas J Begley; Christian Desaintes; Anne-Claude Gavin; Richard Pelroy; Joris Pothof; Yosef Shiloh; Dik van Gent; Bennett Van Houten; Michael Yaffe; Leon Mullenders
3rd US-EU workshop: systems level understanding of DNA damage responses.
Mutation research 2010;692(1-2):53-60.
2010: Xiaohua Peng; Anil Ghosh; Bennett Van Houten; Marc M Greenberg
Nucleotide excision repair of a DNA interstrand cross-link produces single- and double-strand breaks.
Biochemistry 2010;49(1):11-9.
2010: Windy A Boyd; Tracey L Crocker; Ana M Rodriguez; Maxwell C K Leung; D Wade Lehmann; Jonathan H Freedman; Bennett Van Houten; Joel N Meyer
Nucleotide excision repair genes are expressed at low levels and are not detectably inducible in Caenorhabditis elegans somatic tissues, but their function is required for normal adult life after UVC exposure.
Mutation research 2010;683(1-2):57-67.
2010: Astrid C Haugen; Nicholas A Di Prospero; Joel Parker; Rick D Fannin; Jeff Chou; Joel N Meyer; Christopher Halweg; Jennifer B Collins; Alexandra Durr; Kenneth Fischbeck; Bennett Van Houten
Altered gene expression and DNA damage in peripheral blood cells from Friedreich's ataxia patients: cellular model of pathology.
PLoS genetics 2010;6(1):e1000812.
2009: Toshiaki Nakano; Atsushi Katafuchi; Mayumi Matsubara; Hiroaki Terato; Tomohiro Tsuboi; Tasuku Masuda; Takahiro Tatsumoto; Seung Pil Pack; Keisuke Makino; Deborah L Croteau; Bennett Van Houten; Kenta Iijima; Hiroshi Tauchi; Hiroshi Ide
Homologous recombination but not nucleotide excision repair plays a pivotal role in tolerance of DNA-protein cross-links in mammalian cells.
The Journal of biological chemistry 2009;284(40):27065-76.
2009: Lei Jia; Konstantin Kropachev; Shuang Ding; Bennett Van Houten; Nicholas E Geacintov; Suse Broyde
Exploring damage recognition models in prokaryotic nucleotide excision repair with a benzo[a]pyrene-derived lesion in UvrB.
Biochemistry 2009;48(38):8948-57.
2009: Jonathan T Sczepanski; Aaron C Jacobs; Bennett Van Houten; Marc M Greenberg
Double-strand break formation during nucleotide excision repair of a DNA interstrand cross-link.
Biochemistry 2009;48(32):7565-7.
2009: Jill Engel-Cox; Bennett Van Houten; Jerry Phelps; Shyanika Rose
Conceptual model of comprehensive research metrics for improved human health and environment.
Ciência & saúde coletiva 2009;14(2):519-31.
2009: Wenjian Ma; Vijayalakshmi Panduri; Joan F Sterling; Bennett Van Houten; Dmitry A Gordenin; Michael A Resnick
The transition of closely opposed lesions to double-strand breaks during long-patch base excision repair is prevented by the coordinated action of DNA polymerase delta and Rad27/Fen1.
Molecular and cellular biology 2009;29(5):1212-21.
2008: Stefanie C Wolski; Jochen Kuper; Petra Hänzelmann; James J Truglio; Deborah L Croteau; Bennett Van Houten; Caroline Kisker
Crystal structure of the FeS cluster-containing nucleotide excision repair helicase XPD.
PLoS biology 2008;6(6):e149.
2008: Hong Wang; Ingrid Tessmer; Deborah L Croteau; Dorothy A Erie; Bennett Van Houten
Functional characterization and atomic force microscopy of a DNA repair protein conjugated to a quantum dot.
Nano letters 2008;8(6):1631-7.
2008: Deborah L Croteau; Ye Peng; Bennett Van Houten
DNA repair gets physical: mapping an XPA-binding site on ERCC1.
DNA repair 2008;7(5):819-26.
2008: Jill A Engel-Cox; Bennett Van Houten; Jerry Phelps; Shyanika Rose
Conceptual model of comprehensive research metrics for improved human health and environment.
Environmental health perspectives 2008;116(5):583-92.
2008: Shuhei Imoto; Leslie A Bransfield; Deborah L Croteau; Bennett Van Houten; Marc M Greenberg
DNA tandem lesion repair by strand displacement synthesis and nucleotide excision repair.
Biochemistry 2008;47(14):4306-16.
2008: Christina H Drew; Martha I Barnes; Jerry Phelps; Bennett Van Houten
NIEHS extramural global environmental health portfolio: opportunities for collaboration.
Environmental health perspectives 2008;116(4):421-5.
2007: Matthew J DellaVecchia; W Keither Merritt; Ye Peng; Thomas W Kirby; Eugene F DeRose; Geoffrey A Mueller; Bennett Van Houten; Robert E London
NMR analysis of [methyl-13C]methionine UvrB from Bacillus caldotenax reveals UvrB-domain 4 heterodimer formation in solution.
Journal of molecular biology 2007;373(2):282-95.
2007: Qian Ruan; Tongming Liu; Alexander Kolbanovskiy; Yang Liu; Jian Ren; Milan Skorvaga; Yue Zou; Joshua Lader; Brijesh Malkani; Shantu Amin; Bennett Van Houten; Nicholas E Geacintov
Sequence context- and temperature-dependent nucleotide excision repair of a benzo[a]pyrene diol epoxide-guanine DNA adduct catalyzed by thermophilic UvrABC proteins.
Biochemistry 2007;46(23):7006-15.
2007: Albert R Wielgus; Colin F Chignell; David S Miller; Bennett Van Houten; Joel Meyer; Dan-Ning Hu; Joan E Roberts
Phototoxicity in human retinal pigment epithelial cells promoted by hypericin, a component of St. John's wort.
Photochemistry and photobiology 2007;83(3):706-13.
2007: Sherine Chan; Janine H Santos; Joel N Meyer; Bhaskar S Mandavilli; Dennis L Cook; Consuelo L McCash; Grace E Kissling; Abraham Nyska; Julie F Foley; Bennett Van Houten; William C Copeland; Vernon E Walker; Kristine L Witt; Jack B Bishop
Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination.
Environmental and molecular mutagenesis 2007;48(3-4):190-200.
2007: Erkan Karakas; James J Truglio; Deborah L Croteau; Benjamin Rhau; Liqun Wang; Bennett Van Houten; Caroline Kisker
Structure of the C-terminal half of UvrC reveals an RNase H endonuclease domain with an Argonaute-like catalytic triad.
The EMBO journal 2007;26(2):613-22.
2007: Joel N Meyer; Windy A Boyd; Gregory A Azzam; Astrid C Haugen; Jonathan H Freedman; Bennett Van Houten
Decline of nucleotide excision repair capacity in aging Caenorhabditis elegans.
Genome biology 2007;8(5):R70.
2006: Deborah L Croteau; Matthew J DellaVecchia; Hong Wang; Rachelle J Bienstock; Mark A Melton; Bennett Van Houten
The C-terminal zinc finger of UvrA does not bind DNA directly but regulates damage-specific DNA binding.
The Journal of biological chemistry 2006;281(36):26370-81.
2006: Miriam Sander; Christian Desaintes; Wouter Ferro; Leon H F Mullenders; Harry Vrieling; Richard Pelroy; Bennett Van Houten; Susan Wallace
Meeting report. Second EU-US workshop on systems level understanding of DNA damage responses.
Mutation research 2006;599(1-2):178-204.
2006: Guo Hui Jiang; Milan Skorvaga; Deborah L Croteau; Bennett Van Houten; J.Christopher States
Robust incision of Benoz[a]pyrene-7,8-dihyrodiol-9,10-epoxide-DNA adducts by a recombinant thermoresistant interspecies combination UvrABC endonuclease system.
Biochemistry 2006;45(25):7834-43.
2006: Hong Wang; Matthew J DellaVecchia; Milan Skorvaga; Deborah L Croteau; Dorothy A Erie; Bennett Van Houten
UvrB domain 4, an autoinhibitory gate for regulation of DNA binding and ATPase activity.
The Journal of biological chemistry 2006;281(22):15227-37.
2006: Thomas A Kunkel; Bennett Van Houten
Survival choices.
Nature cell biology 2006;8(6):547-9.
2006: Janine H Santos; Joel N Meyer; Bennett Van Houten
Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis.
Human molecular genetics 2006;15(11):1757-68.
2006: Miriam Sander; Bennett Van Houten
Integrating multiple views of the cell: DNA repair jumps to higher level at Stowe workshop.
DNA repair 2006;5(4):523-7.
2006: James J Truglio; Erkan Karakas; Benjamin Rhau; Hong Wang; Matthew J DellaVecchia; Bennett Van Houten; Caroline Kisker
Structural basis for DNA recognition and processing by UvrB.
Nature structural & molecular biology 2006;13(4):360-4.
2006: Bennett Van Houten; Victoria Woshner; Janine H Santos
Role of mitochondrial DNA in toxic responses to oxidative stress.
DNA repair 2006;5(2):145-52.
2006: James J Truglio; Deborah L Croteau; Bennett Van Houten; Caroline Kisker
Prokaryotic nucleotide excision repair: the UvrABC system.
Chemical reviews 2006;106(2):233-52.
2006: Gregory R Stuart; Janine H Santos; Micheline K Strand; Bennett Van Houten; William C Copeland
Mitochondrial and nuclear DNA defects in Saccharomyces cerevisiae with mutations in DNA polymerase gamma associated with progressive external ophthalmoplegia.
Human molecular genetics 2006;15(2):363-74.
2006: Janine H Santos; Joel N Meyer; Bhaskar S Mandavilli; Bennett Van Houten
Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells.
Methods in molecular biology (Clifton, N.J.) 2006;314():183-99.
2005: Miriam Sander; Jean Cadet; Daniel A Casciano; Sheila M Galloway; Lawrence J Marnett; Raymond F Novak; syril director pettit; R Julian Preston; Julie A Skare; Gary M Williams; Bennett Van Houten; B Bhaskar Gollapudi
Proceedings of a workshop on DNA adducts: biological significance and applications to risk assessment Washington, DC, April 13-14, 2004.
Toxicology and applied pharmacology 2005;208(1):1-20.
2005: Bennett Van Houten; Deborah L Croteau; Matthew J DellaVecchia; Hong Wang; Caroline Kisker
'Close-fitting sleeves': DNA damage recognition by the UvrABC nuclease system.
Mutation research 2005;577(1-2):92-117.
2005: Marc W Fariss; Catherine B Chan; Manisha Patel; Bennett Van Houten; Sten Orrenius
Role of mitochondria in toxic oxidative stress.
Molecular interventions 2005;5(2):94-111.
2005: James J Truglio; Benjamin Rhau; Deborah L Croteau; Liqun Wang; Milan Skorvaga; Erkan Karakas; Matthew J DellaVecchia; Hong Wang; Bennett Van Houten; Caroline Kisker
Structural insights into the first incision reaction during nucleotide excision repair.
The EMBO journal 2005;24(5):885-94.
2005: Irina G Minko; Andrew J Kurtz; Deborah L Croteau; Bennett Van Houten; Thomas Harris; R Stephen Lloyd
Initiation of repair of DNA-polypeptide cross-links by the UvrABC nuclease.
Biochemistry 2005;44(8):3000-9.
2005: Bhaskar S Mandavilli; Istvan Boldogh; Bennett Van Houten
3-nitropropionic acid-induced hydrogen peroxide, mitochondrial DNA damage, and cell death are attenuated by Bcl-2 overexpression in PC12 cells.
Brain research. Molecular brain research 2005;133(2):215-23.
2005: Toshiaki Nakano; Atsushi Katafuchi; Hiroaki Terato; Toshinori Suzuki; Bennett Van Houten; Hiroshi Ide
Activity of nucleotide excision repair enzymes for oxanine cross-link lesions.
Nucleic acids symposium series (2004) 2005;(49):293-4.
2005: Toshiaki Nakano; Atsushi Katafuchi; Ryoko Shimizu; Hiroaki Terato; Toshinori Suzuki; Hiroshi Tauchi; Keisuke Makino; Milan Skorvaga; Bennett Van Houten; Hiroshi Ide
Repair activity of base and nucleotide excision repair enzymes for guanine lesions induced by nitrosative stress.
Nucleic acids research 2005;33(7):2181-91.
2004: Janice Onuki; Yiming Chen; Priscila C Teixeira; Robert Schumacher; Marisa H G Medeiros; Bennett Van Houten; Paolo Di Mascio
Mitochondrial and nuclear DNA damage induced by 5-aminolevulinic acid.
Archives of biochemistry and biophysics 2004;432(2):178-87.
2004: Milan Skorvaga; Matthew J DellaVecchia; Deborah L Croteau; Karsten Theis; James J Truglio; Bhaskar S Mandavilli; Caroline Kisker; Bennett Van Houten
Identification of residues within UvrB that are important for efficient DNA binding and damage processing.
The Journal of biological chemistry 2004;279(49):51574-80.
2004: Miroslav Pirsel; Miroslav Chovanec; Andrej Dudás; Karol Kleibl; Bennett Van Houten
Fourth DNA repair workshop on DNA damage and repair: mechanisms and biological consequences Smolenice Castle, 2-5 May 2004.
DNA repair 2004;3(12):1639-59.
2004: Janine H Santos; Joel N Meyer; Milan Skorvaga; Lois A Annab; Bennett Van Houten
Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage.
Aging cell 2004;3(6):399-411.
2004: Matthew J DellaVecchia; Deborah L Croteau; Milan Skorvaga; Sergey V Dezhurov; Olga I Lavrik; Bennett Van Houten
Analyzing the handoff of DNA from UvrA to UvrB utilizing DNA-protein photoaffinity labeling.
The Journal of biological chemistry 2004;279(43):45245-56.
2004: Eugenia Trushina; Roy B Dyer; John D Badger; Daren Ure; Lars Eide; David D Tran; Brent T Vrieze; Valerie Legendre-Guillemin; Peter S McPherson; Bhaskar S Mandavilli; Bennett Van Houten; Scott Zeitlin; Mark McNiven; Ruedi Aebersold; Michael Hayden; Joseph E Parisi; Erling Seeberg; Ioannis Dragatsis; Kelly Doyle; Anna Bender; Celin Chacko; Cynthia T McMurray
Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro.
Molecular and cellular biology 2004;24(18):8195-209.
2004: James J Truglio; Deborah L Croteau; Milan Skorvaga; Matthew J DellaVecchia; Karsten Theis; Bhaskar S Mandavilli; Bennett Van Houten; Caroline Kisker
Interactions between UvrA and UvrB: the role of UvrB's domain 2 in nucleotide excision repair.
The EMBO journal 2004;23(13):2498-509.
2004: Miriam Sander; Christian Desaintes; Richard Pelroy; Wouter Ferro; Bennett Van Houten; Sally A Amundson; Alan Lehmann; Leon H F Mullenders; Susanna-Assunta Sansone; Peter Stambrook; Bert van Zeeland; Harry Vrieling; Anders Wennborg
Meeting report: EU-US Workshop on Molecular Signatures of DNA Damage-Induced Stress Responses. Cortona, Italy, 26-30 September 2003.
Mutation research 2004;550(1-2):145-81.
2004: Guohui Jiang; Ryszard Jankowiak; Nenad M Grubor; Marzena Banasiewicz; Gerald J Small; Milan Skorvaga; Bennett Van Houten; J.Christopher States
Supercoiled DNA promotes formation of intercalated cis-N2-deoxyguanine adducts and base-stacked trans-N2-deoxyguanine adducts by (+)-7R,8S-dihydrodiol-9S,10R-epoxy-7,8,9,10-tetra- hydrobenzo[a]pyrene.
Chemical research in toxicology 2004;17(3):330-9.
2004: Astrid C Haugen; Ryan Kelley; Jennifer B Collins; Charles J Tucker; Changchun Deng; Cynthia A Afshari; J Martin Brown; Trey Ideker; Bennett Van Houten
Integrating phenotypic and expression profiles to map arsenic-response networks.
Genome biology 2004;5(12):R95.
2003: Gopalakrishnan Karthikeyan; Janine H Santos; Maria A Graziewicz; William C Copeland; Grazia Isaya; Bennett Van Houten; Michael A Resnick
Reduction in frataxin causes progressive accumulation of mitochondrial damage.
Human molecular genetics 2003;12(24):3331-42.
2003: Arti Shukla; Michael Jung; Maria Stern; Naomi K Fukagawa; Douglas J Taatjes; Dennis Sawyer; Bennett Van Houten; Brooke T Mossman
Asbestos induces mitochondrial DNA damage and dysfunction linked to the development of apoptosis.
American journal of physiology. Lung cellular and molecular physiology 2003;285(5):L1018-25.
2003: Yi-Zhe Wang; Jennifer L Ingram; Dianne M Walters; Annette B Rice; Janine H Santos; Bennett Van Houten; James C Bonner
Vanadium-induced STAT-1 activation in lung myofibroblasts requires H2O2 and P38 MAP kinase.
Free radical biology & medicine 2003;35(8):845-55.
2003: GuoHui Jiang; Milan Skorvaga; Bennett Van Houten; J.Christopher States
Reduced sulfhydryls maintain specific incision of BPDE-DNA adducts by recombinant thermoresistant Bacillus caldotenax UvrABC endonuclease.
Protein expression and purification 2003;31(1):88-98.
2003: Sandy Dubaele; Luca Proietti de Santis; Rachelle J Bienstock; Anne Keriel; Miria Stefanini; Bennett Van Houten; Jean-Marc Egly
Basal transcription defect discriminates between xeroderma pigmentosum and trichothiodystrophy in XPD patients.
Molecular cell 2003;11(6):1635-46.
2003: Jennifer L Ingram; Annette B Rice; Janine Santos; Bennett Van Houten; James C Bonner
Vanadium-induced HB-EGF expression in human lung fibroblasts is oxidant dependent and requires MAP kinases.
American journal of physiology. Lung cellular and molecular physiology 2003;284(5):L774-82.
2003: Rachelle J Bienstock; Milan Skorvaga; Bhaskar S Mandavilli; Bennett Van Houten
Structural and functional characterization of the human DNA repair helicase XPD by comparative molecular modeling and site-directed mutagenesis of the bacterial repair protein UvrB.
The Journal of biological chemistry 2003;278(7):5309-16.
2003: Janine H Santos; L'uba Hunakova; Yiming Chen; Carl Bortner; Bennett Van Houten
Cell sorting experiments link persistent mitochondrial DNA damage with loss of mitochondrial membrane potential and apoptotic cell death.
The Journal of biological chemistry 2003;278(3):1728-34.
2003: Michael Waters; Gary A Boorman; Pierre R Bushel; Michael Cunningham; Rick Irwin; Alex Merrick; Stephanie Holmgren; Richard S Paules; James K Selkirk; Stanley Stasiewicz; Brenda Weis; Bennett Van Houten; Nigel Walker; Raymond W Tennant
Systems toxicology and the Chemical Effects in Biological Systems (CEBS) knowledge base.
EHP toxicogenomics : journal of the National Institute of Environmental Health Sciences 2003;111(1T):15-28.
2002: Bhaskar S Mandavilli; Janine H Santos; Bennett Van Houten
Mitochondrial DNA repair and aging.
Mutation research 2002;509(1-2):127-51.
2002: Robert W Sobol; David E Watson; Jun Nakamura; F Michael Yakes; Esther W Hou; Julie K Horton; Joseph Ladapo; Bennett Van Houten; James A Swenberg; Kenneth Tindall; Leona D Samson; Samuel H Wilson
Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6860-5.
2002: Bennett Van Houten; Jonathan Eisen; Philip C Hanawalt
A cut above: discovery of an alternative excision repair pathway in bacteria.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2581-3.
2002: Agnieszka Kowalczyk; J Russ Carmical; Yue Zou; Bennett Van Houten; R Stephen Lloyd; Constance M Harris; Thomas Harris
Intrastrand DNA cross-links as tools for studying DNA replication and repair: two-, three-, and four-carbon tethers between the N(2) positions of adjacent guanines.
Biochemistry 2002;41(9):3109-18.
2002: Milan Skorvaga; Karsten Theis; Bhaskar S Mandavilli; Caroline Kisker; Bennett Van Houten
The beta -hairpin motif of UvrB is essential for DNA binding, damage processing, and UvrC-mediated incisions.
The Journal of biological chemistry 2002;277(2):1553-9.
2002: Lilia M Iakoucheva; Randall K Walker; Bennett Van Houten; Eric J Ackerman
Equilibrium and stop-flow kinetic studies of fluorescently labeled DNA substrates with DNA repair proteins XPA and replication protein A.
Biochemistry 2002;41(1):131-43.
2002: Janine H Santos; Bhaskar S Mandavilli; Bennett Van Houten
Measuring oxidative mtDNA damage and repair using quantitative PCR.
Methods in molecular biology (Clifton, N.J.) 2002;197():159-76.
2000: Bhaskar S Mandavilli; S F Ali; Bennett Van Houten
DNA damage in brain mitochondria caused by aging and MPTP treatment.
Brain research 2000;885(1):45-52.
2000: S Hoare; Yue Zou; V Purohit; R Krishnasamy; Milan Skorvaga; Bennett Van Houten; Nicholas E Geacintov; Ashis K Basu
Differential incision of bulky carcinogen-DNA adducts by the UvrABC nuclease: comparison of incision rates and the interactions of Uvr subunits with lesions of different structures.
Biochemistry 2000;39(40):12252-61.
2000: S Ayala-Torres; Y Chen; T Svoboda; Judah Rosenblatt; Bennett Van Houten
Analysis of gene-specific DNA damage and repair using quantitative polymerase chain reaction.
Methods (San Diego, Calif.) 2000;22(2):135-47.
2000: Bennett Van Houten; J Phelps; M Barnes; W A Suk
Evaluating scientific impact.
Environmental health perspectives 2000;108(9):A392-3.
2000: Karsten Theis; Milan Skorvaga; Mischa Machius; N Nakagawa; Bennett Van Houten; Caroline Kisker
The nucleotide excision repair protein UvrB, a helicase-like enzyme with a catch.
Mutation research 2000;460(3-4):277-300.
2000: Bennett Van Houten; S Cheng; Y Chen
Measuring gene-specific nucleotide excision repair in human cells using quantitative amplification of long targets from nanogram quantities of DNA.
Mutation research 2000;460(2):81-94.
2000: J Russ Carmical; Agnieszka Kowalczyk; Yue Zou; Bennett Van Houten; Lubomir V Nechev; Constance M Harris; Thomas Harris; R Stephen Lloyd
Butadiene-induced intrastrand DNA cross-links: a possible role in deletion mutagenesis.
The Journal of biological chemistry 2000;275(26):19482-9.
2000: D Chandrasekhar; Bennett Van Houten
In vivo formation and repair of cyclobutane pyrimidine dimers and 6-4 photoproducts measured at the gene and nucleotide level in Escherichia coli.
Mutation research 2000;450(1-2):19-40.
2000: Scott W Ballinger; Winston Patterson; C N Yan; R Doan; David L Burow; Christal G Young; F Michael Yakes; Bennett Van Houten; Carol A Ballinger; Bruce Freeman; Marschall S Runge
Hydrogen peroxide- and peroxynitrite-induced mitochondrial DNA damage and dysfunction in vascular endothelial and smooth muscle cells.
Circulation research 2000;86(9):960-6.
1999: Karsten Theis; P J Chen; Milan Skorvaga; Bennett Van Houten; Caroline Kisker
Crystal structure of UvrB, a DNA helicase adapted for nucleotide excision repair.
The EMBO journal 1999;18(24):6899-907.
1999: G Deng; Joseph H Su; KJ Ivins; Bennett Van Houten; Carl W Cotman
Bcl-2 facilitates recovery from DNA damage after oxidative stress.
Experimental neurology 1999;159(1):309-18.
1999: Yue Zou; Bennett Van Houten
Strand opening by the UvrA(2)B complex allows dynamic recognition of DNA damage.
The EMBO journal 1999;18(17):4889-901.
1999: Julie K Horton; G Roy; JT Piper; Bennett Van Houten; Yogesh C Awasthi; S Mitra; M A Alaoui-Jamali; Istvan Boldogh; shashank singhal
Characterization of a chlorambucil-resistant human ovarian carcinoma cell line overexpressing glutathione S-transferase mu.
Biochemical pharmacology 1999;58(4):693-702.
1999: DE Sawyer; Bennett Van Houten
Repair of DNA damage in mitochondria.
Mutation research 1999;434(3):161-76.
1999: Scott W Ballinger; Bennett Van Houten; Gui-Fang Jin; C A Conklin; Bernard F Godley
Hydrogen peroxide causes significant mitochondrial DNA damage in human RPE cells.
Experimental eye research 1999;68(6):765-72.
1998: Yue Zou; Heather M Bassett; R Walker; A Bishop; S Amin; NE Geacintov; Bennett Van Houten
Hydrophobic forces dominate the thermodynamic characteristics of UvrA-DNA damage interactions.
Journal of molecular biology 1998;281(1):107-19.
1998: Bennett Van Houten; Y Chen; Janice A Nicklas; Irene R Rainville; J Patrick O'Neill
Development of long PCR techniques to analyze deletion mutations of the human hprt gene.
Mutation research 1998;403(1-2):171-5.
1998: Yue Zou; D J Crowley; Bennett Van Houten
Involvement of molecular chaperonins in nucleotide excision repair. Dnak leads to increased thermal stability of UvrA, catalytic UvrB loading, enhanced repair, and increased UV resistance.
The Journal of biological chemistry 1998;273(21):12887-92.
1998: KH Chen; F Michael Yakes; Deepak K Srivastava; R K Singhal; Robert W Sobol; Julie K Horton; Bennett Van Houten; Samuel H Wilson
Up-regulation of base excision repair correlates with enhanced protection against a DNA damaging agent in mouse cell lines.
Nucleic acids research 1998;26(8):2001-7.
1998: H Fung; Yoke W Kow; Bennett Van Houten; Douglas J Taatjes; Zafer Hatahet; YM Janssen; Pamela M Vacek; Stephen P Faux; Brooke T Mossman
Asbestos increases mammalian AP-endonuclease gene expression, protein levels, and enzyme activity in mesothelial cells.
Cancer research 1998;58(2):189-94.
1997: James J Salazar; Bennett Van Houten
Preferential mitochondrial DNA injury caused by glucose oxidase as a steady generator of hydrogen peroxide in human fibroblasts.
Mutation research 1997;385(2):139-49.
1997: H Fung; Yoke W Kow; Bennett Van Houten; Brooke T Mossman
Patterns of 8-hydroxydeoxyguanosine formation in DNA and indications of oxidative stress in rat and human pleural mesothelial cells after exposure to crocidolite asbestos.
Carcinogenesis 1997;18(4):825-32.
1997: Yue Zou; R Walker; Heather M Bassett; NE Geacintov; Bennett Van Houten
Formation of DNA repair intermediates and incision by the ATP-dependent UvrB-UvrC endonuclease.
The Journal of biological chemistry 1997;272(8):4820-7.
1997: F Michael Yakes; Bennett Van Houten
Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(2):514-9.
1995: Yue Zou; T M Liu; N E Geacintov; Bennett Van Houten
Interaction of the UvrABC nuclease system with a DNA duplex containing a single stereoisomer of dG-(+)- or dG-(-)-anti-BPDE.
Biochemistry 1995;34(41):13582-93.
1994: D Chandrasekhar; Bennett Van Houten
Fine-mapping DNA damage in E. coli.
Annals of the New York Academy of Sciences 1994;726():295-8.
1994: Bennett Van Houten; Amanda K McCullough
Nucleotide excision repair in E. coli.
Annals of the New York Academy of Sciences 1994;726():236-51.
1994: P K Wu; Y Qu; Bennett Van Houten; Nicholas Farrell
Chemical reactivity and DNA sequence specificity of formally monofunctional and bifunctional bis(platinum) complexes.
Journal of inorganic biochemistry 1994;54(3):207-20.
1994: Y Zou; Bennett Van Houten; Nicholas Farrell
Sequence specificity of DNA-DNA interstrand cross-link formation by cisplatin and dinuclear platinum complexes.
Biochemistry 1994;33(18):5404-10.
1994: D Chandrasekhar; Bennett Van Houten
High resolution mapping of UV-induced photoproducts in the Escherichia coli lacI gene. Inefficient repair of the non-transcribed strand correlates with high mutation frequency.
Journal of molecular biology 1994;238(3):319-32.
1993: Bennett Van Houten; Sharon Illenye; Y Qu; Nicholas Farrell
Homodinuclear (Pt,Pt) and heterodinuclear (Ru,Pt) metal compounds as DNA-protein cross-linking agents: potential suicide DNA lesions.
Biochemistry 1993;32(44):11794-801.
1993: Y Zou; Bennett Van Houten; Nicholas Farrell
Ligand effects on platinum binding to DNA. A comparison of DNA binding properties for cis- and trans-[PtCl2(amine)2] (amine = NH3, pyridine).
Biochemistry 1993;32(37):9632-8.
1993: YM Janssen; Bennett Van Houten; Paul J A Borm; Brooke T Mossman
Cell and tissue responses to oxidative damage.
Laboratory investigation; a journal of technical methods and pathology 1993;69(3):261-74.
1993: Bennett Van Houten; A Snowden
Mechanism of action of the Escherichia coli UvrABC nuclease: clues to the damage recognition problem.
BioEssays : news and reviews in molecular, cellular and developmental biology 1993;15(1):51-9.
1992: D P Kalinowski; Sharon Illenye; Bennett Van Houten
Analysis of DNA damage and repair in murine leukemia L1210 cells using a quantitative polymerase chain reaction assay.
Nucleic acids research 1992;20(13):3485-94.
1992: A Johnson; Y Qu; Bennett Van Houten; Nicholas Farrell
B----Z DNA conformational changes induced by a family of dinuclear bis(platinum) complexes.
Nucleic acids research 1992;20(7):1697-703.
1992: Bennett Van Houten; Yoke W Kow
DNA damage, mutations, cancer, and aging. American Association for Cancer Research Special Conference: Cellular Responses to Environmental DNA Damage, Banff, AB, Canada, December 1-6, 1991.
The New biologist 1992;4(4):306-15.
1991: A Snowden; Bennett Van Houten
Initiation of the UvrABC nuclease cleavage reaction. Efficiency of incision is not correlated with UvrA binding affinity.
Journal of molecular biology 1991;220(1):19-33.
1990: Nicholas Farrell; Y Qu; L Feng; Bennett Van Houten
Comparison of chemical reactivity, cytotoxicity, interstrand cross-linking and DNA sequence specificity of bis(platinum) complexes containing monodentate or bidentate coordination spheres with their monomeric analogues.
Biochemistry 1990;29(41):9522-31.
1990: A Snowden; Yoke W Kow; Bennett Van Houten
Damage repertoire of the Escherichia coli UvrABC nuclease complex includes abasic sites, base-damage analogues, and lesions containing adjacent 5' or 3' nicks.
Biochemistry 1990;29(31):7251-9.
1990: Yoke W Kow; Susan S Wallace; Bennett Van Houten
UvrABC nuclease complex repairs thymine glycol, an oxidative DNA base damage.
Mutation research 1990;235(2):147-56.
1990: Bennett Van Houten
Nucleotide excision repair in Escherichia coli.
Microbiological reviews 1990;54(1):18-51.
1989: J D Roberts; Bennett Van Houten; Y Qu; Nicholas Farrell
Interaction of novel bis(platinum) complexes with DNA.
Nucleic acids research 1989;17(23):9719-33.