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Karel Wirtz

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Martijn Schenning; Joachim Goedhart; Theodorus W J Gadella; Diana Avram; Karel W A Wirtz; Gerry Snoek
The anti-apoptotic activity associated with phosphatidylinositol transfer protein alpha activates the MAPK and Akt/PKB pathway.
Martijn Schenning; Claudia M van Tiel; Karel W A Wirtz; Gerry Snoek
The anti-apoptotic MAP kinase pathway is inhibited in NIH3T3 fibroblasts with increased expression of phosphatidylinositol transfer protein beta.
Karel W A Wirtz
Phospholipid transfer proteins in perspective.

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2008: Martijn Schenning; Joachim Goedhart; Theodorus W J Gadella; Diana Avram; Karel W A Wirtz; Gerry Snoek
The anti-apoptotic activity associated with phosphatidylinositol transfer protein alpha activates the MAPK and Akt/PKB pathway.
Biochimica et biophysica acta 2008;1783(10):1700-6.
2007: Martijn Schenning; Claudia M van Tiel; Karel W A Wirtz; Gerry Snoek
The anti-apoptotic MAP kinase pathway is inhibited in NIH3T3 fibroblasts with increased expression of phosphatidylinositol transfer protein beta.
Biochimica et biophysica acta 2007;1773(11):1664-71.
2006: Karel W A Wirtz
Phospholipid transfer proteins in perspective.
FEBS letters 2006;580(23):5436-41.
2006: Boris V Chernyak; Denis S Izyumov; Konstantin Lyamzaev; Alina A Pashkovskaya; Olga Yu Pletjushkina; Yuri N Antonenko; Dmitrii V Sakharov; Karel W A Wirtz; Vladimir P Skulachev
Production of reactive oxygen species in mitochondria of HeLa cells under oxidative stress.
Biochimica et biophysica acta 2006;1757(5-6):525-34.
2006: Hanneke Bunte; Martijn Schenning; Peter Sodaar; Dop P R Bär; Karel W A Wirtz; Freek Van Muiswinkel; Gerry Snoek
A phosphatidylinositol transfer protein alpha-dependent survival factor protects cultured primary neurons against serum deprivation-induced cell death.
Journal of neurochemistry 2006;97(3):707-15.
2006: Karel W A Wirtz; Arie Schouten; Piet Gros
Phosphatidylinositol transfer proteins: from closed for transport to open for exchange.
Advances in enzyme regulation 2006;46():301-11.
2005: Dmitri V Sakharov; E D R Elstak; Boris V Chernyak; Karel W A Wirtz
Prolonged lipid oxidation after photodynamic treatment. Study with oxidation-sensitive probe C11-BODIPY581/591.
FEBS letters 2005;579(5):1255-60.
2004: Diana Avram; Edwin Romijn; Everard Pap; albert heck; Karel W A Wirtz
Identification of proteins in activated human neutrophils susceptible to tyrosyl radical attack. A proteomic study using a tyrosylating fluorophore.
Proteomics 2004;4(8):2397-407.
2004: Martijn Schenning; Claudia M van Tiel; Daniëlle Van Manen; Jord Stam; Bart M Gadella; Karel W A Wirtz; Gerry Snoek
Phosphatidylinositol transfer protein alpha regulates growth and apoptosis of NIH3T3 cells: involvement of a cannabinoid 1-like receptor.
Journal of lipid research 2004;45(8):1555-64.
2004: Denis S Izyumov; Armine V Avetisyan; Olga Yu Pletjushkina; Dmitrii V Sakharov; Karel W A Wirtz; Boris V Chernyak; Vladimir P Skulachev
"Wages of fear": transient threefold decrease in intracellular ATP level imposes apoptosis.
Biochimica et biophysica acta 2004;1658(1-2):141-7.
2004: Claudia M van Tiel; Martijn Schenning; Gerry Snoek; Karel W A Wirtz
Overexpression of phosphatidylinositol transfer protein beta in NIH3T3 cells has a stimulatory effect on sphingomyelin synthesis and apoptosis.
Biochimica et biophysica acta 2004;1636(2-3):151-8.
2004: Tobias B Dansen; Geert J P L Kops; Simone Denis; Nannette Jelluma; Ronald J A Wanders; Johannes L Bos; Boudewijn M T Burgering; Karel W A Wirtz
Regulation of sterol carrier protein gene expression by the forkhead transcription factor FOXO3a.
Journal of lipid research 2004;45(1):81-8.
2003: Dmitri V Sakharov; Anton Bunschoten; Huib van Weelden; Karel W A Wirtz
Photodynamic treatment and H2O2-induced oxidative stress result in different patterns of cellular protein oxidation.
European journal of biochemistry / FEBS 2003;270(24):4859-65.
2003: Dennis van der Vlies; Miriam Makkinje; Annemieke Jansens; Ineke Braakman; Arie J Verkleij; Karel W A Wirtz; Jan Andries Post
Oxidation of ER resident proteins upon oxidative stress: effects of altering cellular redox/antioxidant status and implications for protein maturation.
Antioxidants & redox signaling 2003;5(4):381-7.
2002: Claudia M van Tiel; Arie Schouten; Gerry Snoek; Piet Gros; Karel W A Wirtz
The structure of phosphatidylinositol transfer protein alpha reveals sites for phospholipid binding and membrane association with major implications for its function.
FEBS letters 2002;531(1):69-73.
2002: Geert J P L Kops; Tobias B Dansen; Paulien E Polderman; Ingrid Saarloos; Karel W A Wirtz; Paul J Coffer; Ting-T Huang; Johannes L Bos; René H Medema; Boudewijn M T Burgering
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress.
Nature 2002;419(6904):316-21.
2002: Dennis van der Vlies; Everard Pap; Jan Andries Post; Julio E Celis; Karel W A Wirtz
Endoplasmic reticulum resident proteins of normal human dermal fibroblasts are the major targets for oxidative stress induced by hydrogen peroxide.
The Biochemical journal 2002;366(Pt 3):825-30.
2002: Grzegorz Czapski; Diana Avram; Dmitri V Sakharov; Karel W A Wirtz; Joanna B Strosznajder; Everard Pap
Activated neutrophils oxidize extracellular proteins of endothelial cells in culture: effect of nitric oxide donors.
The Biochemical journal 2002;365(Pt 3):897-902.
2002: Arjan de Brouwer; C Versluis; Jan Westerman; B Roelofsen; albert heck; Karel W A Wirtz
Determination of the stability of the noncovalent phospholipid transfer protein-lipid complex by electrospray time-of-flight mass spectrometry.
Biochemistry 2002;41(25):8013-8.
2002: Claudia M van Tiel; Jan Westerman; Marten A Paasman; Martha M Hoebens; Karel W A Wirtz; Gerry Snoek
The Golgi localization of phosphatidylinositol transfer protein beta requires the protein kinase C-dependent phosphorylation of serine 262 and is essential for maintaining plasma membrane sphingomyelin levels.
The Journal of biological chemistry 2002;277(25):22447-52.
2002: Arie Schouten; Bogos Agianian; Jan Westerman; Jan Kroon; Karel W A Wirtz; Piet Gros
Structure of apo-phosphatidylinositol transfer protein alpha provides insight into membrane association.
The EMBO journal 2002;21(9):2117-21.
2002: Arjan de Brouwer; Jan Westerman; A Kleinnijenhuis; L E Bevers; B Roelofsen; Karel W A Wirtz
Clofibrate-induced relocation of phosphatidylcholine transfer protein to mitochondria in endothelial cells.
Experimental cell research 2002;274(1):100-11.
2001: Arjan de Brouwer; Barend Bouma; Claudia M van Tiel; W Heerma; Jos F Brouwers; L E Bevers; Jan Westerman; B Roelofsen; Karel W A Wirtz
The binding of phosphatidylcholine to the phosphatidylcholine transfer protein: affinity and role in folding.
Chemistry and physics of lipids 2001;112(2):109-19.
2001: Dennis van der Vlies; Karel W A Wirtz; Everard Pap
Detection of protein oxidation in rat-1 fibroblasts by fluorescently labeled tyramine.
Biochemistry 2001;40(26):7783-8.
2001: Grzegorz Czapski; Diana Avram; Karel W A Wirtz; Everard Pap; Joanna B Strosznajder
Detection of protein oxidation in endothelial cells by fluorescently labelled tyramine.
Medical science monitor : international medical journal of experimental and clinical research 2001;7(4):606-9.
2001: Everard Pap; Tobias B Dansen; R van Summeren; Karel W A Wirtz
Peptide-based targeting of fluorophores to organelles in living cells.
Experimental cell research 2001;265(2):288-93.
2001: Tobias B Dansen; Karel W A Wirtz
The peroxisome in oxidative stress.
IUBMB life 2001;51(4):223-30.
2001: Barend Bouma; Jan Westerman; Nick Dekker; Piet Gros; Karel W A Wirtz
Activation of phosphatidylinositol transfer protein alpha and beta isoforms from inclusion bodies.
Biochimica et biophysica acta 2001;1546(1):216-25.
2001: Tobias B Dansen; Ronald J A Wanders; Karel W A Wirtz
Targeted fluorescent probes in peroxisome function.
The Histochemical journal 2001;33(2):65-9.
2001: Everard Pap; Tobias B Dansen; Karel W A Wirtz
Peptide-based targeting of fluorophores to peroxisomes in living cells.
Trends in cell biology 2001;11(1):10-12.
2000: Claudia M van Tiel; Jan Westerman; M Paasman; Karel W A Wirtz; Gerry Snoek
The protein kinase C-dependent phosphorylation of serine 166 is controlled by the phospholipid species bound to the phosphatidylinositol transfer protein alpha.
The Journal of biological chemistry 2000;275(28):21532-8.
2000: Hiroaki Komatsu; Barend Bouma; Karel W A Wirtz; Theodore F Taraschi; Nathan Janes
Activity of phosphatidylinositol transfer protein is sensitive to ethanol and membrane curvature.
The Biochemical journal 2000;348 Pt 3():667-73.
2000: Claudia M van Tiel; Chiara Luberto; Gerry Snoek; Yusuf A Hannun; Karel W A Wirtz
Rapid replenishment of sphingomyelin in the plasma membrane upon degradation by sphingomyelinase in NIH3T3 cells overexpressing the phosphatidylinositol transfer protein beta.
The Biochemical journal 2000;346 Pt 2():537-43.
2000: Everard Pap; Gregor Drummen; Jan Andries Post; P J Rijken; Karel W A Wirtz
Fluorescent fatty acid to monitor reactive oxygen in single cells.
Methods in enzymology 2000;319():603-12.
2000: Tobias B Dansen; Karel W A Wirtz; Ronald J A Wanders; Everard Pap
Peroxisomes in human fibroblasts have a basic pH.
Nature cell biology 2000;2(1):51-3.
1999: Gerry Snoek; Christopher P Berrie; T B Geijtenbeek; HA Van der Helm; J A Cadeé; Cristiano Iurisci; Daniela Corda; Karel W A Wirtz
Overexpression of phosphatidylinositol transfer protein alpha in NIH3T3 cells activates a phospholipase A.
The Journal of biological chemistry 1999;274(50):35393-9.
1999: Ardy van Helvoort; Arjan de Brouwer; Roelof Ottenhoff; Jos F Brouwers; Jan Wijnholds; Jos H Beijnen; A Rijneveld; T van der Poll; Martin van der Valk; Donné M Majoor; W Voorhout; Karel W A Wirtz; Ronald P J Oude Elferink; Piet Borst
Mice without phosphatidylcholine transfer protein have no defects in the secretion of phosphatidylcholine into bile or into lung airspaces.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11501-6.
1999: Everard Pap; Gregor Drummen; V J Winter; T W Kooij; P Rijken; Karel W A Wirtz; Jos A F Op den Kamp; WJ Hage; Jan Andries Post
Ratio-fluorescence microscopy of lipid oxidation in living cells using C11-BODIPY(581/591).
FEBS letters 1999;453(3):278-82.
1999: Tobias B Dansen; Jan Westerman; FS Wouters; Ronald J A Wanders; A van Hoek; Theodorus W J Gadella; Karel W A Wirtz
High-affinity binding of very-long-chain fatty acyl-CoA esters to the peroxisomal non-specific lipid-transfer protein (sterol carrier protein-2).
The Biochemical journal 1999;339 ( Pt 1)():193-9.
1998: FS Wouters; Philippe I H Bastiaens; Karel W A Wirtz; T M Jovin
FRET microscopy demonstrates molecular association of non-specific lipid transfer protein (nsL-TP) with fatty acid oxidation enzymes in peroxisomes.
The EMBO journal 1998;17(24):7179-89.
1998: Marie E Monaco; R J Alexander; Gerry Snoek; Nancy H Moldover; Karel W A Wirtz; Paul D Walden
Evidence that mammalian phosphatidylinositol transfer protein regulates phosphatidylcholine metabolism.
The Biochemical journal 1998;335 ( Pt 1)():175-9.
1998: Karel W A Wirtz; FS Wouters; P H Bastiaens; Ronald J A Wanders; Udo Seedorf; T M Jovin
The non-specific lipid transfer protein (sterol carrier protein 2) acts as a peroxisomal fatty acyl-CoA binding protein.
Biochemical Society transactions 1998;26(3):374-8.
1998: Ronald J A Wanders; Simone Denis; E van Berkel; FS Wouters; Karel W A Wirtz; Udo Seedorf
Identification of the newly discovered 58 kDa peroxisomal thiolase SCPx as the main thiolase involved in both pristanic acid and trihydroxycholestanoic acid oxidation: implications for peroxisomal beta-oxidation disorders.
Journal of inherited metabolic disease 1998;21(3):302-5.
1998: Udo Seedorf; M Raabe; Peter Ellinghaus; Frank Kannenberg; Manfred Fobker; Thomas Engel; Simone Denis; FS Wouters; Karel W A Wirtz; Ronald J A Wanders; Nobuyo Maeda; Gerd Assmann
Defective peroxisomal catabolism of branched fatty acyl coenzyme A in mice lacking the sterol carrier protein-2/sterol carrier protein-x gene function.
Genes & development 1998;12(8):1189-201.
1997: O Tüscher; C Lorra; Barend Bouma; Karel W A Wirtz; Wieland B Huttner
Cooperativity of phosphatidylinositol transfer protein and phospholipase D in secretory vesicle formation from the TGN--phosphoinositides as a common denominator?
FEBS letters 1997;419(2-3):271-5.
1997: Ronald J A Wanders; Simone Denis; FS Wouters; Karel W A Wirtz; Udo Seedorf
Sterol carrier protein X (SCPx) is a peroxisomal branched-chain beta-ketothiolase specifically reacting with 3-oxo-pristanoyl-CoA: a new, unique role for SCPx in branched-chain fatty acid metabolism in peroxisomes.
Biochemical and biophysical research communications 1997;236(3):565-9.
1997: Karel W A Wirtz
Phospholipid transfer proteins revisited.
The Biochemical journal 1997;324 ( Pt 2)():353-60.
1996: B C Ossendorp; WF Voorhout; A van Amerongen; F Brunink; Joseph J Batenburg; Karel W A Wirtz
Tissue-specific distribution of a peroxisomal 46-kDa protein related to the 58-kDa protein (sterol carrier protein x; sterol carrier protein 2/3-oxoacyl-CoA thiolase).
Archives of biochemistry and biophysics 1996;334(2):251-60.
1996: K J De Vries; J Westerman; Philippe I H Bastiaens; T M Jovin; Karel W A Wirtz; Gerry Snoek
Fluorescently labeled phosphatidylinositol transfer protein isoforms (alpha and beta), microinjected into fetal bovine heart endothelial cells, are targeted to distinct intracellular sites.
Experimental cell research 1996;227(1):33-9.
1996: T B Geijtenbeek; J Westerman; W Heerma; Karel W A Wirtz
Phosphatidylcholine transfer protein from bovine liver contains highly unsaturated phosphatidylcholine species.
FEBS letters 1996;391(3):333-5.
1995: K J de Vries; A A Heinrichs; E Cunningham; F Brunink; J Westerman; Pentti Somerharju; S Cockcroft; Karel W A Wirtz; Gerry Snoek
An isoform of the phosphatidylinositol-transfer protein transfers sphingomyelin and is associated with the Golgi system.
The Biochemical journal 1995;310 ( Pt 2)():643-9.
1995: Everard Pap; A Hanicak; Arie van Hoek; Karel W A Wirtz; Antonie J W G Visser
Quantitative analysis of lipid-lipid and lipid-protein interactions in membranes by use of pyrene-labeled phosphoinositides.
Biochemistry 1995;34(28):9118-25.
1995: J Westerman; K J de Vries; Pentti Somerharju; J L Timmermans-Hereijgers; Gerry Snoek; Karel W A Wirtz
A sphingomyelin-transferring protein from chicken liver. Use of pyrene-labeled phospholipid.
The Journal of biological chemistry 1995;270(24):14263-6.
1994: B C Ossendorp; WF Voorhout; Lambert M G van Golde; Karel W A Wirtz; Joseph J Batenburg
Identification of the non-specific lipid-transfer protein (sterol carrier protein 2) in peroxisomes of lung type II cells.
Biochemical and biophysical research communications 1994;205(3):1581-8.
1994: K J de Vries; A Momchilova-Pankova; Gerry Snoek; Karel W A Wirtz
A novel acidic form of the phosphatidylinositol transfer protein is preferentially retained in permeabilized Swiss mouse 3T3 fibroblasts.
Experimental cell research 1994;215(1):109-13.
1994: T B Geijtenbeek; E de Groot; J van Baal; F Brunink; J Westerman; Gerry Snoek; Karel W A Wirtz
Characterization of mouse phosphatidylinositol transfer protein expressed in Escherichia coli.
Biochimica et biophysica acta 1994;1213(3):309-18.
1994: A Hanicak; D Maretzki; B Reimann; Everard Pap; Antonie J W G Visser; Karel W A Wirtz; D Schubert
Erythrocyte band 3 protein strongly interacts with phosphoinositides.
FEBS letters 1994;348(2):169-72.
1994: Theodorus W J Gadella; Karel W A Wirtz
Phospholipid binding and transfer by the nonspecific lipid-transfer protein (sterol carrier protein 2). A kinetic model.
European journal of biochemistry / FEBS 1994;220(3):1019-28.
1994: Joseph J Batenburg; B C Ossendorp; Gerry Snoek; Karel W A Wirtz; Martin Houweling; R H Elfring
Phospholipid-transfer proteins and their mRNAs in developing rat lung and in alveolar type-II cells.
The Biochemical journal 1994;298 ( Pt 1)():223-9.
1993: Everard Pap; Philippe I H Bastiaens; Jan Willem Borst; P A van den Berg; Arie van Hoek; Gerry Snoek; Karel W A Wirtz; Antonie J W G Visser
Quantitation of the interaction of protein kinase C with diacylglycerol and phosphoinositides by time-resolved detection of resonance energy transfer.
Biochemistry 1993;32(48):13310-7.
1993: A Moritz; J Westerman; P N E De Graan; Bernard Payrastre; Willem Hendrik Gispen; Karel W A Wirtz
Characterization of phosphatidylinositol-4-phosphate 5-kinase activities from bovine brain membranes.
Biochimica et biophysica acta 1993;1168(1):79-86.
1993: Gerry Snoek; I S de Wit; Karel W A Wirtz
Properties and intracellular localization of phosphatidylinositol transfer protein in Swiss mouse 3T3 cells.
Biochemical Society transactions 1993;21(2):244-7.
1993: Gerry Snoek; J Westerman; FS Wouters; Karel W A Wirtz
Phosphorylation and redistribution of the phosphatidylinositol-transfer protein in phorbol 12-myristate 13-acetate- and bombesin-stimulated Swiss mouse 3T3 fibroblasts.
The Biochemical journal 1993;291 ( Pt 2)():649-56.
1993: B C Ossendorp; Karel W A Wirtz
The non-specific lipid-transfer protein (sterol carrier protein 2) and its relationship to peroxisomes.
Biochimie 1993;75(3-4):191-200.
1992: Gerry Snoek; I S de Wit; J H van Mourik; Karel W A Wirtz
The phosphatidylinositol transfer protein in 3T3 mouse fibroblast cells is associated with the Golgi system.
Journal of cellular biochemistry 1992;49(4):339-48.
1992: G M van Wijk; Theodorus W J Gadella; Karel W A Wirtz; Karl Y Hostetler; H van den Bosch
Spontaneous and protein-mediated intermembrane transfer of the antiretroviral liponucleotide 3'-deoxythymidine diphosphate diglyceride.
Biochemistry 1992;31(25):5912-7.
1992: G P van Heusden; J R van Beckhoven; R Thieringer; C R Raetz; Karel W A Wirtz
Increased cholesterol synthesis in Chinese hamster ovary cells deficient in peroxisomes.
Biochimica et biophysica acta 1992;1126(1):81-7.
1992: A Moritz; P N E De Graan; Willem Hendrik Gispen; Karel W A Wirtz
Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase.
The Journal of biological chemistry 1992;267(11):7207-10.
1992: L van Haren; K J Teerds; B C Ossendorp; G P van Heusden; J Orly; D M Stocco; Karel W A Wirtz; F F Rommerts
Sterol carrier protein 2 (non-specific lipid transfer protein) is localized in membranous fractions of Leydig cells and Sertoli cells but not in germ cells.
Biochimica et biophysica acta 1992;1124(3):288-96.
1992: B C Ossendorp; T B Geijtenbeek; Karel W A Wirtz
The precursor form of the rat liver non-specific lipid-transfer protein, expressed in Escherichia coli, has lipid transfer activity.
FEBS letters 1992;296(2):179-83.
1992: G P van Heusden; B C Ossendorp; Karel W A Wirtz
Subcellular distribution of nonspecific lipid transfer protein from rat tissues.
Methods in enzymology 1992;209():535-43.
1992: Pentti Somerharju; J Kasurinen; Karel W A Wirtz
Transfer activity and acyl-chain specificity of phosphatidylcholine transfer protein by fluorescence assays.
Methods in enzymology 1992;209():495-504.
1991: Theodorus W J Gadella; Karel W A Wirtz
The low-affinity lipid binding site of the non-specific lipid transfer protein. Implications for its mode of action.
Biochimica et biophysica acta 1991;1070(1):237-45.
1991: J Bernd Helms; K J de Vries; Karel W A Wirtz
Synthesis of phosphatidylinositol 4,5-bisphosphate in the endoplasmic reticulum of Chinese hamster ovary cells.
The Journal of biological chemistry 1991;266(32):21368-74.
1991: B C Ossendorp; G P Van Heusden; A L De Beer; K Bos; G L Schouten; Karel W A Wirtz
Identification of the cDNA clone which encodes the 58-kDa protein containing the amino acid sequence of rat liver non-specific lipid-transfer protein (sterol-carrier protein 2). Homology with rat peroxisomal and mitochondrial 3-oxoacyl-CoA thiolases.
European journal of biochemistry / FEBS 1991;201(1):233-9.
1991: Theodorus W J Gadella; Philippe I H Bastiaens; Antonie J W G Visser; Karel W A Wirtz
Shape and lipid-binding site of the nonspecific lipid-transfer protein (sterol carrier protein 2): a steady-state and time-resolved fluorescence study.
Biochemistry 1991;30(22):5555-64.
1991: Karel W A Wirtz
Phospholipid transfer proteins: from lipid monolayers to cells.
Klinische Wochenschrift 1991;69(3):105-11.
1991: Karel W A Wirtz
Phospholipid transfer proteins.
Annual review of biochemistry 1991;60():73-99.
1990: Willem van den Akker; J Westerman; Theodorus W J Gadella; Karel W A Wirtz; Gerry Snoek
Proteolytic activation of a bovine brain protein with phosphatidylinositol transfer activity.
FEBS letters 1990;276(1-2):123-6.
1990: J Bernd Helms; A Karrenbauer; Karel W A Wirtz; James E Rothman; Felix T Wieland
Reconstitution of steps in the constitutive secretory pathway in permeabilized cells. Secretion of glycosylated tripeptide and truncated sphingomyelin.
The Journal of biological chemistry 1990;265(32):20027-32.
1990: Karel W A Wirtz; Gerry Snoek; Theodorus W J Gadella; P A van Paridon; Pentti Somerharju
Properties and possible function of phosphatidylinositol-transfer proteins.
Biotechnology and applied biochemistry 1990;12(5):485-8.
1990: G P Van Heusden; K Bos; Karel W A Wirtz
The occurrence of soluble and membrane-bound non-specific lipid transfer protein (sterol carrier protein 2) in rat tissues.
Biochimica et biophysica acta 1990;1046(3):315-21.
1990: J Kasurinen; P A van Paridon; Karel W A Wirtz; Pentti Somerharju
Affinity of phosphatidylcholine molecular species for the bovine phosphatidylcholine and phosphatidylinositol transfer proteins. Properties of the sn-1 and sn-2 acyl binding sites.
Biochemistry 1990;29(37):8548-54.
1990: Karel W A Wirtz; Theodorus W J Gadella
Properties and modes of action of specific and non-specific phospholipid transfer proteins.
Experientia 1990;46(6):592-9.
1990: Klaas Nicolay; R Hovius; R Bron; Karel W A Wirtz; Ben de Kruijff
The phosphatidylcholine-transfer protein catalyzed import of phosphatidylcholine into isolated rat liver mitochondria.
Biochimica et biophysica acta 1990;1025(1):49-59.
1990: B C Ossendorp; G P van Heusden; Karel W A Wirtz
The amino acid sequence of rat liver non-specific lipid transfer protein (sterol carrier protein 2) is present in a high molecular weight protein: evidence from cDNA analysis.
Biochemical and biophysical research communications 1990;168(2):631-6.
1990: Theodorus W J Gadella; A Moritz; J Westerman; Karel W A Wirtz
Enzymatic synthesis of pyrene-labeled polyphosphoinositides and their behavior in organic solvents and phosphatidylcholine bilayers.
Biochemistry 1990;29(13):3389-95.
1990: G P van Heusden; K Bos; C R Raetz; Karel W A Wirtz
Chinese hamster ovary cells deficient in peroxisomes lack the nonspecific lipid transfer protein (sterol carrier protein 2).
The Journal of biological chemistry 1990;265(7):4105-10.
1990: Pentti Somerharju; P A van Paridon; Karel W A Wirtz
Application of fluorescent phospholipid analogues to studies on phospholipid transfer proteins.
Sub-cellular biochemistry 1990;16():21-43.
1990: A Moritz; P N E De Graan; P F Ekhart; Willem Hendrik Gispen; Karel W A Wirtz
Purification of a phosphatidylinositol 4-phosphate kinase from bovine brain membranes.
Journal of neurochemistry 1990;54(1):351-4.
1989: G P van Heusden; J W van Schijndel; Karel W A Wirtz
Cholesterol transfer from mitochondrial membranes and cells to human and rat serum lipoprotein fractions.
Journal of lipid research 1989;30(9):1357-64.
1989: A van Amerongen; Rudy A Demel; J Westerman; Karel W A Wirtz
Transfer of cholesterol and oxysterol derivatives by the nonspecific lipid transfer protein (sterol carrier protein 2): a study on its mode of action.
Biochimica et biophysica acta 1989;1004(1):36-43.
1989: A van Amerongen; M van Noort; J R van Beckhoven; F F Rommerts; J Orly; Karel W A Wirtz
The subcellular distribution of the nonspecific lipid transfer protein (sterol carrier protein 2) in rat liver and adrenal gland.
Biochimica et biophysica acta 1989;1001(3):243-8.
1988: P A van Paridon; Theodorus W J Gadella; Pentti Somerharju; Karel W A Wirtz
Properties of the binding sites for the sn-1 and sn-2 acyl chains on the phosphatidylinositol transfer protein from bovine brain.
Biochemistry 1988;27(17):6208-14.
1988: P A Van Paridon; Theodorus W J Gadella; Karel W A Wirtz
The effect of polyphosphoinositides and phosphatidic acid on the phosphatidylinositol transfer protein from bovine brain: a kinetic study.
Biochimica et biophysica acta 1988;943(1):76-86.
1988: M van Noort; F F Rommerts; A van Amerongen; Karel W A Wirtz
Intracellular redistribution of SCP2 in Leydig cells after hormonal stimulation may contribute to increased pregnenolone production.
Biochemical and biophysical research communications 1988;154(1):60-5.
1988: M van Noort; F F Rommerts; A van Amerongen; Karel W A Wirtz
Regulation of sterol carrier protein2 (SCP2) levels in the soluble fraction of rat Leydig cells. Kinetics and the possible role of calcium influx.
Molecular and cellular endocrinology 1988;56(1-2):133-40.
1988: P A van Paridon; J K Shute; Karel W A Wirtz; Antonie J W G Visser
A fluorescence decay study of parinaroyl-phosphatidylinositol incorporated into artificial and natural membranes.
European biophysics journal : EBJ 1988;16(1):53-63.
1987: Pentti Somerharju; D van Loon; Karel W A Wirtz
Determination of the acyl chain specificity of the bovine liver phosphatidylcholine transfer protein. Application of pyrene-labeled phosphatidylcholine species.
Biochemistry 1987;26(22):7193-9.
1987: P A Van Paridon; Theodorus W J Gadella; Pentti Somerharju; Karel W A Wirtz
On the relationship between the dual specificity of the bovine brain phosphatidylinositol transfer protein and membrane phosphatidylinositol levels.
Biochimica et biophysica acta 1987;903(1):68-77.
1987: P A Van Paridon; Pentti Somerharju; Karel W A Wirtz
Phosphatidylinositol-transfer protein and cellular phosphatidylinositol metabolism.
Biochemical Society transactions 1987;15(3):321-3.
1987: P A Van Paridon; Antonie J W G Visser; Karel W A Wirtz
Binding of phospholipids to the phosphatidylinositol transfer protein from bovine brain as studied by steady-state and time-resolved fluorescence spectroscopy.
Biochimica et biophysica acta 1987;898(2):172-80.
1986: D van Loon; J Westerman; R Akeroyd; Karel W A Wirtz
Identification of an essential lysine residue in the phosphatidylcholine-transfer protein from bovine liver by modification with phenylisothiocyanate.
European journal of biochemistry / FEBS 1986;157(2):347-50.
1986: M van Noort; F F Rommerts; A van Amerongen; Karel W A Wirtz
Localization and hormonal regulation of the non-specific lipid transfer protein (sterol carrier protein2) in the rat testis.
The Journal of endocrinology 1986;109(3):R13-6.
1983: P Somerharju; P Van Paridon; Karel W A Wirtz
Phosphatidylinositol transfer protein from bovine brain. Substrate specificity and membrane binding properties.
Biochimica et biophysica acta 1983;731(2):186-95.
1983: J Westerman; Karel W A Wirtz; T Berkhout; L L van Deenen; R Radhakrishnan; H Gobind Khorana
Identification of the lipid-binding site of phosphatidylcholine-transfer protein with phosphatidylcholine analogs containing photoactivable carbene precursors.
European journal of biochemistry / FEBS 1983;132(2):441-9.
1982: R Akeroyd; J A Lenstra; J Westerman; G Vriend; Karel W A Wirtz; L L van Deenen
Prediction of secondary structural elements in the phosphatidylcholine-transfer protein from bovine liver.
European journal of biochemistry / FEBS 1982;121(2):391-4.
1981: R Akeroyd; L G Lange; J Westerman; Karel W A Wirtz
Modification of the phosphatidylcholine-transfer protein from bovine liver with butanedione and phenylglyoxal. Evidence for one essential arginine residue.
European journal of biochemistry / FEBS 1981;121(1):77-81.
1981: R Akeroyd; P Moonen; J Westerman; W C Puyk; Karel W A Wirtz
The complete primary structure of the phosphatidylcholine-transfer protein from bovine liver. Isolation and characterization of the cyanogen bromide peptides.
European journal of biochemistry / FEBS 1981;114(2):385-91.
1980: P Moonen; R Akeroyd; J Westerman; W C Puijk; P Smits; Karel W A Wirtz
The primary structure of the phosphatidylcholine-exchange protein from bovine liver. Isolation and characterization of the staphylococcal protease peptides and the amino-acid sequence of the N-terminal half (residues 1--122).
European journal of biochemistry / FEBS 1980;106(1):279-90.
1980: Karel W A Wirtz; P Moonen; L L van Deenen; R Radhakrishnan; H Gobind Khorana
Identification of the lipid binding site of the phosphatidylcholine exchange protein with a photosensitive nitrene and carbene precursor of phosphatidylcholine.
Annals of the New York Academy of Sciences 1980;348():244-55.