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Wendy Dean

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Stefanie Seisenberger; Fátima Santos; Wendy Dean; Timothy A Hore; Julian R Peat; Wolf Reik
Reprogramming DNA methylation in the mammalian life cycle: building and breaking epigenetic barriers.
Stefanie Seisenberger; Bernard Thienpont; Jörn Walter; Fátima Santos; Simon Andrews; Julia Arand; Wendy Dean; Felix Krueger; Christian Popp; Wolf Reik
The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells.
Samuel P Rowbotham; Leila Barki; Ana Neves-Costa; Fatima Santos; Wendy Dean; Nicola Hawkes; Parul Choudhary; W Ryan Will; Judith Webster; David Oxley; Catherine Green; Patrick Varga-Weisz; Jacqueline E Mermoud
Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.

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All Publications

2013: Stefanie Seisenberger; Fátima Santos; Wendy Dean; Timothy A Hore; Julian R Peat; Wolf Reik
Reprogramming DNA methylation in the mammalian life cycle: building and breaking epigenetic barriers.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2013;368(1609):20110330.
2012: Stefanie Seisenberger; Bernard Thienpont; Jörn Walter; Fátima Santos; Simon Andrews; Julia Arand; Wendy Dean; Felix Krueger; Christian Popp; Wolf Reik
The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells.
Molecular cell 2012;48(6):849-62.
2011: Samuel P Rowbotham; Leila Barki; Ana Neves-Costa; Fatima Santos; Wendy Dean; Nicola Hawkes; Parul Choudhary; W Ryan Will; Judith Webster; David Oxley; Catherine Green; Patrick Varga-Weisz; Jacqueline E Mermoud
Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.
Molecular cell 2011;42(3):285-96.
2010: Fátima Santos; Louise Hyslop; Petra Stojkovic; Christine Leary; Alison Murdoch; Wolf Reik; Miodrag Stojkovic; Mary Herbert; Wendy Dean
Evaluation of epigenetic marks in human embryos derived from IVF and ICSI.
Human reproduction (Oxford, England) 2010;25(9):2387-95.
2010: Christian Popp; Wendy Dean; Suhua Feng; Shawn J Cokus; Simon Andrews; Matteo Pellegrini; Steven E Jacobsen; Wolf Reik
Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency.
Nature 2010;463(7284):1101-5.
2009: Myriam Hemberger; Wendy Dean; Wolf Reik
Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal.
Nature reviews. Molecular cell biology 2009;10(8):526-37.
2009: Mita Chotalia; Sebastien A Smallwood; Nico Ruf; Claire Dawson; Diana Lucifero; Margalida Frontera; Katherine James; Wendy Dean; Gavin Kelsey
Transcription is required for establishment of germline methylation marks at imprinted genes.
Genes & development 2009;23(1):105-17.
2008: Ray Kit Ng; Wendy Dean; Claire Dawson; Diana Lucifero; Zofia Madeja; Wolf Reik; Myriam Hemberger
Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5.
Nature cell biology 2008;10(11):1280-90.
2008: Mark Screen; Wendy Dean; James C Cross; Myriam Hemberger
Cathepsin proteases have distinct roles in trophoblast function and vascular remodelling.
Development (Cambridge, England) 2008;135(19):3311-20.
2008: Wendy Dean
The elusive Dnmt1 and its role during early development.
Epigenetics : official journal of the DNA Methylation Society 2008;3(4):175-8.
2008: Cassandra R Farthing; Gabriella Ficz; Ray Kit Ng; Chun-Fung Chan; Simon Andrews; Wendy Dean; Myriam Hemberger; Wolf Reik
Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes.
PLoS genetics 2008;4(6):e1000116.
2007: Aline V Probst; Fátima Santos; Wolf Reik; Geneviève Almouzni; Wendy Dean
Structural differences in centromeric heterochromatin are spatially reconciled on fertilisation in the mouse zygote.
Chromosoma 2007;116(4):403-15.
2007: Myriam Hemberger; Wendy Dean
Epigenetic arbitration of cell fate decisions: tipping the bias.
Developmental cell 2007;12(2):176-8.
2007: Kelly Green; Annabelle Lewis; Claire Dawson; Wendy Dean; Brenda J Reinhart; J Richard Chaillet; Wolf Reik
A developmental window of opportunity for imprinted gene silencing mediated by DNA methylation and the Kcnq1ot1 noncoding RNA.
Mammalian genome : official journal of the International Mammalian Genome Society 2007;18(1):32-42.
2006: E Angiolini; Abigail Fowden; Philip Coan; Ionel Sandovici; Paul Smith; Wendy Dean; G Burton; B Tycko; Wolf Reik; Colin Sibley; Miguel Constância
Regulation of placental efficiency for nutrient transport by imprinted genes.
Placenta 2006;27 Suppl A():S98-102.
2006: Lyle Armstrong; Majlinda Lako; Wendy Dean; Miodrag Stojkovic
Epigenetic modification is central to genome reprogramming in somatic cell nuclear transfer.
Stem cells (Dayton, Ohio) 2006;24(4):805-14.
2006: Fátima Santos; Wendy Dean
Using immunofluorescence to observe methylation changes in mammalian preimplantation embryos.
Methods in molecular biology (Clifton, N.J.) 2006;325():129-37.
2005: Miguel Constância; Emily Angiolini; Ionel Sandovici; Paul Smith; Rachel Smith; Gavin Kelsey; Wendy Dean; Anne C Ferguson-Smith; Colin P Sibley; Wolf Reik; Abigail Fowden
Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(52):19219-24.
2005: Wendy Dean; Diana Lucifero; Fátima Santos
DNA methylation in mammalian development and disease.
Birth defects research. Part C, Embryo today : reviews 2005;75(2):98-111.
2005: Hugh D Morgan; Fátima Santos; Kelly Green; Wendy Dean; Wolf Reik
Epigenetic reprogramming in mammals.
Human molecular genetics 2005;14 Spec No 1():R47-58.
2005: Antonius Plagge; Anthony R Isles; Emma Gordon; Trevor Humby; Wendy Dean; Sabine Gritsch; Reiner Fischer-Colbrie; Lawrence S Wilkinson; Gavin Kelsey
Imprinted Nesp55 influences behavioral reactivity to novel environments.
Molecular and cellular biology 2005;25(8):3019-26.
2005: Fátima Santos; Antoine H Peters; Arie P Otte; Wolf Reik; Wendy Dean
Dynamic chromatin modifications characterise the first cell cycle in mouse embryos.
Developmental biology 2005;280(1):225-36.
2005: Flavia Cerrato; Angela Sparago; Ines Di Matteo; Xiangang Zou; Wendy Dean; Hiroyuki Sasaki; Paul Smith; Rita Genesio; Marianne Bruggemann; Wolf Reik; Andrea Riccio
The two-domain hypothesis in Beckwith-Wiedemann syndrome: autonomous imprinting of the telomeric domain of the distal chromosome 7 cluster.
Human molecular genetics 2005;14(4):503-11.
2004: Hugh D Morgan; Wendy Dean; Heather A Coker; Wolf Reik; Svend K Petersen-Mahrt
Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming.
The Journal of biological chemistry 2004;279(50):52353-60.
2004: Annabelle Lewis; Kohzoh Mitsuya; David Umlauf; Paul Smith; Wendy Dean; Joern Walter; Michael J Higgins; Robert Feil; Wolf Reik
Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation.
Nature genetics 2004;36(12):1291-5.
2004: Dan Ma; Julian P H Shield; Wendy Dean; Isabelle Leclerc; Claude Knauf; R éMy Burcelin R; Guy Rutter; Gavin Kelsey
Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM.
The Journal of clinical investigation 2004;114(3):339-48.
2004: Antonius Plagge; Emma Gordon; Wendy Dean; Romina Boiani; Saverio Cinti; Jo Peters; Gavin Kelsey
The imprinted signaling protein XL alpha s is required for postnatal adaptation to feeding.
Nature genetics 2004;36(8):818-26.
2004: Fátima Santos; Wendy Dean
Epigenetic reprogramming during early development in mammals.
Reproduction (Cambridge, England) 2004;127(6):643-51.
2004: Colin P Sibley; Philip Coan; Anne C Ferguson-Smith; Wendy Dean; J Hughes; Paul Smith; Wolf Reik; Graham J Burton; Abigail Fowden; Miguel Constância
Placental-specific insulin-like growth factor 2 (Igf2) regulates the diffusional exchange characteristics of the mouse placenta.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(21):8204-8.
2004: Wolf Reik; Adele Murrell; Annabelle Lewis; Kohzoh Mitsuya; David Umlauf; Wendy Dean; Michael J Higgins; Robert Feil
Chromosome loops, insulators, and histone methylation: new insights into regulation of imprinting in clusters.
Cold Spring Harbor symposia on quantitative biology 2004;69():29-37.
2003: Flavia Cerrato; Wendy Dean; Karen Davies; Kazuhiro Kagotani; Kohzoh Mitsuya; Katsuzumi Okumura; Andrea Riccio; Wolf Reik
Paternal imprints can be established on the maternal Igf2-H19 locus without altering replication timing of DNA.
Human molecular genetics 2003;12(23):3123-32.
2003: Wolf Reik; Fátima Santos; Kohzoh Mitsuya; Hugh Morgan; Wendy Dean
Epigenetic asymmetry in the mammalian zygote and early embryo: relationship to lineage commitment?
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2003;358(1436):1403-9; discussion 1409.
2003: Candice Coombes; philippe arnaud; Emma Gordon; Wendy Dean; Elizabeth A Coar; Christine M Williamson; Robert Feil; Jo Peters; Gavin Kelsey
Epigenetic properties and identification of an imprint mark in the Nesp-Gnasxl domain of the mouse Gnas imprinted locus.
Molecular and cellular biology 2003;23(16):5475-88.
2003: Fátima Santos; Valeri Zakhartchenko; Miodrag Stojkovic; Antoine Peters; Thomas Jenuwein; Eckhard Wolf; Wolf Reik; Wendy Dean
Epigenetic marking correlates with developmental potential in cloned bovine preimplantation embryos.
Current biology : CB 2003;13(13):1116-21.
2003: Wolf Reik; Wendy Dean
Gene expression: Silent clones speak up.
Nature 2003;423(6938):390-1.
2003: philippe arnaud; David Monk; Megan P Hitchins; Emma Gordon; Wendy Dean; Colin V Beechey; Jo Peters; William Craigen; Michael Preece; Philip Stanier; Gudrun E Moore; Gavin Kelsey
Conserved methylation imprints in the human and mouse GRB10 genes with divergent allelic expression suggests differential reading of the same mark.
Human molecular genetics 2003;12(9):1005-19.
2003: Rachel J Smith; Wendy Dean; Galia Konfortova; Gavin Kelsey
Identification of novel imprinted genes in a genome-wide screen for maternal methylation.
Genome research 2003;13(4):558-69.
2003: Wolf Reik; Miguel Constância; Abigail Fowden; Neil Anderson; Wendy Dean; Anne C Ferguson-Smith; Benjamin Tycko; Colin Sibley
Regulation of supply and demand for maternal nutrients in mammals by imprinted genes.
The Journal of physiology 2003;547(Pt 1):35-44.
2003: Susana Lopes; Annabelle Lewis; Petra Hajkova; Wendy Dean; Joachim Oswald; Thierry Forné; Adele Murrell; Miguel Constância; Marisa Bartolomei; Jörn Walter; Wolf Reik
Epigenetic modifications in an imprinting cluster are controlled by a hierarchy of DMRs suggesting long-range chromatin interactions.
Human molecular genetics 2003;12(3):295-305.
2003: Natasha Lane; Wendy Dean; Sylvia Erhardt; Petra Hajkova; Azim Surani; Jörn Walter; Wolf Reik
Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse.
Genesis (New York, N.Y. : 2000) 2003;35(2):88-93.
2003: Wendy Dean; Fátima Santos; Wolf Reik
Epigenetic reprogramming in early mammalian development and following somatic nuclear transfer.
Seminars in cell & developmental biology 2003;14(1):93-100.
2003: Wolf Reik; Fátima Santos; Wendy Dean
Mammalian epigenomics: reprogramming the genome for development and therapy.
Theriogenology 2003;59(1):21-32.
2002: Wolf Reik; Wendy Dean
Back to the beginning.
Nature 2002;420(6912):127.
2002: Miguel Constância; Myriam Hemberger; Jennifer Hughes; Wendy Dean; Anne C Ferguson-Smith; Reinald Fundele; Francesca Stewart; Gavin Kelsey; Abigail Fowden; Colin Sibley; Wolf Reik
Placental-specific IGF-II is a major modulator of placental and fetal growth.
Nature 2002;417(6892):945-8.
2002: Rachel J Smith; philippe arnaud; Galia Konfortova; Wendy Dean; Colin V Beechey; Gavin Kelsey
The mouse Zac1 locus: basis for imprinting and comparison with human ZAC.
Gene 2002;292(1-2):101-12.
2002: Karen Davies; Lucy Bowden; Paul Smith; Wendy Dean; David Hill; Hiroyasu Furuumi; Hiroyuki Sasaki; Bruce Cattanach; Wolf Reik
Disruption of mesodermal enhancers for Igf2 in the minute mutant.
Development (Cambridge, England) 2002;129(7):1657-68.
2002: Josef Fulka; Pasqualino Loi; Helena Fulka; Radomir Kren; Wendy Dean; Milan Mrazek; Wolf Reik
Nucleus replacement in Mammalian oocytes.
Cloning and stem cells 2002;4(3):181-7.
2002: Fátima Santos; Brian Hendrich; Wolf Reik; Wendy Dean
Dynamic reprogramming of DNA methylation in the early mouse embryo.
Developmental biology 2002;241(1):172-82.
2001: Adele Murrell; Sarah Heeson; Lucy Bowden; Miguel Constância; Wendy Dean; Gavin Kelsey; Wolf Reik
An intragenic methylated region in the imprinted Igf2 gene augments transcription.
EMBO reports 2001;2(12):1101-6.
2001: Wendy Dean; F Santos; M Stojkovic; Valeri Zakhartchenko; Jörn Walter; E Wolf; Wolf Reik
Conservation of methylation reprogramming in mammalian development: aberrant reprogramming in cloned embryos.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13734-8.
2001: Wolf Reik; Wendy Dean; Jörn Walter
Epigenetic reprogramming in mammalian development.
Science (New York, N.Y.) 2001;293(5532):1089-93.
2001: Wolf Reik; Wendy Dean
DNA methylation and mammalian epigenetics.
Electrophoresis 2001;22(14):2838-43.
2001: Wendy Dean; A Ferguson-Smith
Genomic imprinting: mother maintains methylation marks.
Current biology : CB 2001;11(13):R527-30.
2001: S Eden; Miguel Constancia; Tamar Hashimshony; Wendy Dean; B Goldstein; A C Johnson; Ilana Keshet; Wolf Reik; Howard Cedar
An upstream repressor element plays a role in Igf2 imprinting.
The EMBO journal 2001;20(13):3518-25.
2001: Sanjeev Khosla; Wendy Dean; Wolf Reik; Robert Feil
Culture of preimplantation embryos and its long-term effects on gene expression and phenotype.
Human reproduction update 2001;7(4):419-27.
2001: B Pickard; Wendy Dean; Sabine Engemann; K Bergmann; M Fuermann; M Jung; A Reis; N Allen; Wolf Reik; Jörn Walter
Epigenetic targeting in the mouse zygote marks DNA for later methylation: a mechanism for maternal effects in development.
Mechanisms of development 2001;103(1-2):35-47.
2001: S L Thompson; Galia Konfortova; Richard I Gregory; Wolf Reik; Wendy Dean; Robert Feil
Environmental effects on genomic imprinting in mammals.
Toxicology letters 2001;120(1-3):143-50.
2001: S Khosla; Wendy Dean; D Brown; Wolf Reik; Robert Feil
Culture of preimplantation mouse embryos affects fetal development and the expression of imprinted genes.
Biology of reproduction 2001;64(3):918-26.
2001: Wendy Dean; Gavin Kelsey; Wolf Reik
Generation of monoparental embryos for investigation into genomic imprinting.
Methods in molecular biology (Clifton, N.J.) 2001;181():1-19.
2001: Wolf Reik; Karen Davies; Wendy Dean; Gavin Kelsey; Miguel Constância
Imprinted genes and the coordination of fetal and postnatal growth in mammals.
Novartis Foundation symposium 2001;237():19-31; discussion 31-42.
2000: Miguel Constância; Wendy Dean; S Lopes; T Moore; Gavin Kelsey; Wolf Reik
Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19.
Nature genetics 2000;26(2):203-6.
2000: Joachim Oswald; Sabine Engemann; Natasha Lane; Wolfgang Mayer; Alexander Olek; Reinald Fundele; Wendy Dean; Wolf Reik; Jörn Walter
Active demethylation of the paternal genome in the mouse zygote.
Current biology : CB 2000;10(8):475-8.
2000: Wolf Reik; Miguel Constancia; Wendy Dean; Karen Davies; Lucy Bowden; Adele Murrell; Robert Feil; Jörn Walter; Gavin Kelsey
Igf2 imprinting in development and disease.
The International journal of developmental biology 2000;44(1):145-50.
1999: J Petrik; J M Pell; Edith Arany; TJ McDonald; Wendy Dean; Wolf Reik; David J Hill
Overexpression of insulin-like growth factor-II in transgenic mice is associated with pancreatic islet cell hyperplasia.
Endocrinology 1999;140(5):2353-63.
1999: Stephen J Gaunt; Wendy Dean; H Sang; R D Burton
Evidence that Hoxa expression domains are evolutionarily transposed in spinal ganglia, and are established by forward spreading in paraxial mesoderm.
Mechanisms of development 1999;82(1-2):109-18.
1999: Michael J Skynner; D J Drage; Wendy Dean; S Turner; D J Watt; Nicholas D Allen
Transgenic mice ubiquitously expressing human placental alkaline phosphatase (PLAP): an additional reporter gene for use in tandem with beta-galactosidase (lacZ).
The International journal of developmental biology 1999;43(1):85-90.
1998: M Paulsen; K R Davies; Lucy Bowden; A J Villar; O Franck; M Fuermann; Wendy Dean; T F Moore; N Rodrigues; K E Davies; RJ Hu; Andrew P Feinberg; Eamonn R Maher; Wolf Reik; Jörn Walter
Syntenic organization of the mouse distal chromosome 7 imprinting cluster and the Beckwith-Wiedemann syndrome region in chromosome 11p15.5.
Human molecular genetics 1998;7(7):1149-59.
1998: Wendy Dean; Lucy Bowden; A Aitchison; J Klose; T Moore; J J Meneses; Wolf Reik; Robert Feil
Altered imprinted gene methylation and expression in completely ES cell-derived mouse fetuses: association with aberrant phenotypes.
Development (Cambridge, England) 1998;125(12):2273-82.
1997: Cristina Rada; J Yélamos; Wendy Dean; César Milstein
The 5' hypermutation boundary of kappa chains is independent of local and neighbouring sequences and related to the distance from the initiation of transcription.
European journal of immunology 1997;27(12):3115-20.
1997: F L Sun; Wendy Dean; Gavin Kelsey; Nicholas D Allen; Wolf Reik
Transactivation of Igf2 in a mouse model of Beckwith-Wiedemann syndrome.
Nature 1997;389(6653):809-15.
1997: Thierry Forné; Joachim Oswald; Wendy Dean; JR Saam; B Bailleul; Luisa Dandolo; SM Tilghman; Jörn Walter; Wolf Reik
Loss of the maternal H19 gene induces changes in Igf2 methylation in both cis and trans.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(19):10243-8.
1997: I Roemer; Wolf Reik; Wendy Dean; Joachim Klose
Epigenetic inheritance in the mouse.
Current biology : CB 1997;7(4):277-80.
1996: Ruth Shemer; Y Birger; Wendy Dean; Wolf Reik; A D Riggs; Aharon Razin
Dynamic methylation adjustment and counting as part of imprinting mechanisms.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(13):6371-6.
1996: Wolf Reik; L Bowden; Miguel Constancia; Wendy Dean; Robert Feil; T Forné; Gavin Kelsey; E Maher; T Moore; F L Sun; Jörn Walter
Regulation of Igf2 imprinting in development and disease.
The International journal of developmental biology 1996;Suppl 1():53S-54S.
1994: Fred G Biddle; Brenda A Eales; Wendy Dean
Haldane's rule and heterogametic female and male sterility in the mouse.
Genome / National Research Council Canada = Génome / Conseil national de recherches Canada 1994;37(2):198-202.
1990: Wendy Dean; Gilbert A Schultz
Relocalization of small ribonucleoprotein particles (snRNPs) during the first cell cycle of mouse embryo development is independent of RNA synthesis, DNA synthesis and cytokinesis.
Cell differentiation and development : the official journal of the International Society of Developmental Biologists 1990;31(1):43-51.
1990: R Prather; Calvin Simerly; Gerald Schatten; D R Pilch; S M Lobo; William F Marzluff; Wendy Dean; Gilbert A Schultz
U3 snRNPs and nucleolar development during oocyte maturation, fertilization and early embryogenesis in the mouse: U3 snRNA and snRNPs are not regulated coordinate with other snRNAs and snRNPs.
Developmental biology 1990;138(2):247-55.
1989: Wendy Dean; A C Seufert; Gilbert A Schultz; R S Prather; Calvin Simerly; Gerald Schatten; D R Pilch; William F Marzluff
The small nuclear RNAs for pre-mRNA splicing are coordinately regulated during oocyte maturation and early embryogenesis in the mouse.
Development (Cambridge, England) 1989;106(2):325-34.
1988: S M Lobo; William F Marzluff; A C Seufert; Wendy Dean; Gilbert A Schultz; Calvin Simerly; Gerald Schatten
Localization and expression of U1 RNA in early mouse embryo development.
Developmental biology 1988;127(2):349-61.