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Rob Vandebriel

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Rob Vandebriel; Marcel M N Hoefnagel
Dendritic cell-based in vitro assays for vaccine immunogenicity.
Rob Vandebriel; Hilda J I De Jong; Eric R Gremmer; Olaf H Klungel; Wout Slob; Jan-Willem Cohen Tervaert; Jan Willem Van Der Laan; Henk Van Loveren
Statins accelerate the onset of collagen type II-induced arthritis in mice.
Rob Vandebriel; Sandra Verstraelen; Conchita Callant Cransveld; Daan Crommelin; Zuzana Diamant; Berend Glazenburg; Guy Joos; Frieke Kuper; Andreas Natsch; Frans Nijkamp; Hub Noteborn; Raymond Pieters; David Roberts; Erwin Roggen; Emiel Rorije; Martin Seed; Katharina Sewald; Rosette van den Heuvel; Jacqueline van Engelen; Henk Van Loveren
Respiratory sensitization: advances in assessing the risk of respiratory inflammation and irritation.

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All Publications

2012: Rob Vandebriel; Marcel M N Hoefnagel
Dendritic cell-based in vitro assays for vaccine immunogenicity.
Human vaccines & immunotherapeutics 2012;8(9):1323-5.
2012: Rob Vandebriel; Hilda J I De Jong; Eric R Gremmer; Olaf H Klungel; Wout Slob; Jan-Willem Cohen Tervaert; Jan Willem Van Der Laan; Henk Van Loveren
Statins accelerate the onset of collagen type II-induced arthritis in mice.
Arthritis research & therapy 2012;14(2):R90.
2011: Rob Vandebriel; Sandra Verstraelen; Conchita Callant Cransveld; Daan Crommelin; Zuzana Diamant; Berend Glazenburg; Guy Joos; Frieke Kuper; Andreas Natsch; Frans Nijkamp; Hub Noteborn; Raymond Pieters; David Roberts; Erwin Roggen; Emiel Rorije; Martin Seed; Katharina Sewald; Rosette van den Heuvel; Jacqueline van Engelen; Henk Van Loveren
Respiratory sensitization: advances in assessing the risk of respiratory inflammation and irritation.
Toxicology in vitro : an international journal published in association with BIBRA 2011;25(7):1251-8.
2011: Marcel H N Hoefnagel; Rik J Scheper; Jolanda P Vermeulen; Rob Vandebriel
Response of MUTZ-3 dendritic cells to the different components of the Haemophilus influenzae type B conjugate vaccine: towards an in vitro assay for vaccine immunogenicity.
Vaccine 2011;29(32):5114-21.
2010: Rob Vandebriel; Jeroen L A Pennings; Kirsten A Baken; Tessa E Pronk; Andre Boorsma; Ralph Gottschalk; Henk Van Loveren
Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds.
Toxicological sciences : an official journal of the Society of Toxicology 2010;117(1):81-9.
2010: Rob Vandebriel; Henk Van Loveren
Non-animal sensitization testing: state-of-the-art.
Critical reviews in toxicology 2010;40(5):389-404.
2010: D P K Lankveld; Henk Van Loveren; K A Baken; Rob Vandebriel
In vitro testing for direct immunotoxicity: state of the art.
Methods in molecular biology (Clifton, N.J.) 2010;598():401-23.
2008: Jeroen Geurtsen; Floris Fransen; Rob Vandebriel; Eric R Gremmer; Liset J J de la Fonteyne-Blankestijn; Betsy Kuipers; Jan Tommassen; Peter van der Ley
Supplementation of whole-cell pertussis vaccines with lipopolysaccharide analogs: modification of vaccine-induced immune responses.
Vaccine 2008;26(7):899-906.
2008: Sander Banus; Rachel M Stenger; Eric R Gremmer; J A M A Dormans; Frits R Mooi; Tjeerd G Kimman; Rob Vandebriel
The role of Toll-like receptor-4 in pertussis vaccine-induced immunity.
BMC immunology 2008;9():21.
2007: Sander Banus; Renske W B Bottema; Christine L E Siezen; Rob Vandebriel; Johan H J Reimerink; Monique Mommers; Gerard H Koppelman; Barbara Hoebee; Carel Thijs; Dirkje S Postma; Tjeerd G Kimman; Foekje F Stelma
Toll-like receptor 4 polymorphism associated with the response to whole-cell pertussis vaccination in children from the KOALA study.
Clinical and vaccine immunology : CVI 2007;14(10):1377-80.
2007: Kirsten A Baken; Joanna Arkusz; Jeroen L A Pennings; Rob Vandebriel; Henk Van Loveren
In vitro immunotoxicity of bis(tri-n-butyltin)oxide (TBTO) studied by toxicogenomics.
Toxicology 2007;237(1-3):35-48.
2007: Jeroen Geurtsen; Rob Vandebriel; Eric R Gremmer; Betsy Kuipers; Jan Tommassen; Peter van der Ley
Consequences of the expression of lipopolysaccharide-modifying enzymes for the efficacy and reactogenicity of whole-cell pertussis vaccines.
Microbes and infection / Institut Pasteur 2007;9(9):1096-103.
2007: Jeroen Geurtsen; H Alexander Banus; Eric R Gremmer; Henke Ferguson; Liset J J de la Fonteyne-Blankestijn; Jolanda P Vermeulen; J A M A Dormans; Jan Tommassen; Peter van der Ley; Frits R Mooi; Rob Vandebriel
Lipopolysaccharide analogs improve efficacy of acellular pertussis vaccine and reduce type I hypersensitivity in mice.
Clinical and vaccine immunology : CVI 2007;14(7):821-9.
2007: Sander Banus; Jeroen L A Pennings; Rob Vandebriel; Piet Wester; Timo Breit; Frits R Mooi; Barbara Hoebee; Tjeerd G Kimman
Lung response to Bordetella pertussis infection in mice identified by gene-expression profiling.
Immunogenetics 2007;59(7):555-64.
2007: Rob Vandebriel; Eric R Gremmer; Jolanda P Vermeulen; Sandra M M Hellwig; J A M A Dormans; Paul Roholl; Frits R Mooi
Lung pathology and immediate hypersensitivity in a mouse model after vaccination with pertussis vaccines and challenge with Bordetella pertussis.
Vaccine 2007;25(12):2346-60.
2007: Rob Vandebriel; Eric R Gremmer; Michiel van Hartskamp; J A M A Dormans; Frits R Mooi
Effects of a diphtheria-tetanus-acellular pertussis vaccine on immune responses in murine local lymph node and lung allergy models.
Clinical and vaccine immunology : CVI 2007;14(3):211-9.
2007: Sander Banus; Rob Vandebriel; Jeroen L A Pennings; Eric R Gremmer; Piet W Wester; Henk J van Kranen; Timo M Breit; Peter Demant; Frits R Mooi; Barbara Hoebee; Tjeerd G Kimman
Comparative gene expression profiling in two congenic mouse strains following Bordetella pertussis infection.
BMC microbiology 2007;7():88.
2007: Tjeerd G Kimman; Rob Vandebriel; Barbara Hoebee
Genetic variation in the response to vaccination.
Community genetics 2007;10(4):201-17.
2007: Kirsten A Baken; Rob Vandebriel; Jeroen L A Pennings; Jos C S Kleinjans; Henk Van Loveren
Toxicogenomics in the assessment of immunotoxicity.
Methods (San Diego, Calif.) 2007;41(1):132-41.
2006: H Alexander Banus; Rob Vandebriel; H de Ruiter; J A M A Dormans; N J Nagelkerke; Frits R Mooi; Barbara Hoebee; Henk J van Kranen; Tjeerd G Kimman
Host genetics of Bordetella pertussis infection in mice: significance of Toll-like receptor 4 in genetic susceptibility and pathobiology.
Infection and immunity 2006;74(5):2596-605.
2005: Rob Vandebriel; François M M Van Och; Henk Van Loveren
In vitro assessment of sensitizing activity of low molecular weight compounds.
Toxicology and applied pharmacology 2005;207(2 Suppl):142-8.
2005: G Ehling; M Hecht; A Heusener; J Huesler; AO Gamer; H van Loveren; Th Maurer; K Riecke; L Ullmann; Peter Ulrich; Rob Vandebriel; Hans-Werner Vohr
An European inter-laboratory validation of alternative endpoints of the murine local lymph node assay: first round.
Toxicology 2005;212(1):60-8.
2005: G Ehling; M Hecht; A Heusener; J Huesler; AO Gamer; H van Loveren; Th Maurer; K Riecke; L Ullmann; Peter Ulrich; Rob Vandebriel; Hans-Werner Vohr
An European inter-laboratory validation of alternative endpoints of the murine local lymph node assay: 2nd round.
Toxicology 2005;212(1):69-79.
2005: François M M Van Och; Henk Van Loveren; Josien C Van Wolfswinkel; Anja J C Machielsen; Rob Vandebriel
Assessment of potency of allergenic activity of low molecular weight compounds based on IL-1alpha and IL-18 production by a murine and human keratinocyte cell line.
Toxicology 2005;210(2-3):95-109.
2005: Alessandra Gennari; Masarin Ban; Armin Braun; Silvia Casati; Emanuela Corsini; Jaroslaw Dastych; Jacques Descotes; Thomas Hartung; Robert Hooghe-Peters; Robert House; Marc Pallardy; Raymond Pieters; Lynnda Reid; Helen Tryphonas; Eric Tschirhart; Helga Tuschl; Rob Vandebriel; Laura Gribaldo
The Use of In Vitro Systems for Evaluating Immunotoxicity: The Report and Recommendations of an ECVAM Workshop.
Journal of immunotoxicology 2005;2(2):61-83.
2005: Tove Ringerike; Erik Ullerås; Rene Volker; Bert Verlaan; Ase Eikeset; Dominika Trzaska; Violetta Adamczewska; Maciej Olszewski; Aurelia Walczak-Drzewiecka; Joanna Arkusz; Henk Van Loveren; Gunnar Nilsson; Martinus Lovik; Jaroslaw Dastych; Rob Vandebriel
Detection of immunotoxicity using T-cell based cytokine reporter cell lines ("Cell Chip").
Toxicology 2005;206(2):257-72.
2005: Erik Ullerås; Dominika Trzaska; Joanna Arkusz; Tove Ringerike; Violetta Adamczewska; Maciej Olszewski; Janina Wyczółkowska; Aurelia Walczak-Drzewiecka; Khalid Al-Nedawi; Gunnar Nilsson; Urszula Białek-Wyrzykowska; Maciej Stepnik; Henk Van Loveren; Rob Vandebriel; Martinus Løvik; Konrad Rydzyński; Jaroslaw Dastych
Development of the "Cell Chip": a new in vitro alternative technique for immunotoxicity testing.
Toxicology 2005;206(2):245-56.
2004: Janine Ezendam; Staedtler Frank; Jeroen L A Pennings; Rob Vandebriel; Raymond Pieters; Johannes H Harleman; Joseph G Vos
Toxicogenomics of subchronic hexachlorobenzene exposure in Brown Norway rats.
Environmental health perspectives 2004;112(7):782-91.
2004: Rob Vandebriel
Gene polymorphisms within the immune system that may underlie drug allergy.
Naunyn-Schmiedeberg's archives of pharmacology 2004;369(1):125-32.
2003: Rob Vandebriel; Sandra M M Hellwig; Jolanda P Vermeulen; Jan H G Hoekman; J A M A Dormans; Paul Roholl; Frits R Mooi
Association of Bordetella pertussis with host immune cells in the mouse lung.
Microbial pathogenesis 2003;35(1):19-29.
2003: Rob Vandebriel; Wim H De Jong; Jerome J A Hendriks; Henk Van Loveren
Impact of exposure duration by low molecular weight compounds on interferon-gamma and interleukin-4 mRNA expression and production in the draining lymph nodes of mice.
Toxicology 2003;188(1):1-13.
2003: François M M Van Och; Rob Vandebriel; Wim H De Jong; Henk Van Loveren
Effect of prolonged exposure to low antigen concentration for sensitization.
Toxicology 2003;184(1):23-30.
2002: François M M Van Och; Henk Van Loveren; Wim H De Jong; Rob Vandebriel
Cytokine production induced by low-molecular-weight chemicals as a function of the stimulation index in a modified local lymph node assay: an approach to discriminate contact sensitizers from respiratory sensitizers.
Toxicology and applied pharmacology 2002;184(1):46-56.
2002: Wim H De Jong; Marlies Tentij; S. Spiekstra; Rob Vandebriel; Henk Van Loveren
Determination of the sensitising activity of the rubber contact sensitisers TMTD, ZDMC, MBT and DEA in a modified local lymph node assay and the effect of sodium dodecyl sulfate pretreatment on local lymph node responses.
Toxicology 2002;176(1-2):123-34.
2002: Wim H De Jong; François M M Van Och; Constance F Den Hartog Jager; S. Spiekstra; Wout Slob; Rob Vandebriel; Henk Van Loveren
Ranking of allergenic potency of rubber chemicals in a modified local lymph node assay.
Toxicological sciences : an official journal of the Society of Toxicology 2002;66(2):226-32.
2001: François M M Van Och; Rob Vandebriel; M K Prinsen; Wim H De Jong; Wout Slob; Henk Van Loveren
Comparison of dose-responses of contact allergens using the guinea pig maximization test and the local lymph node assay.
Toxicology 2001;167(3):207-15.
2001: Henk Van Loveren; J G C van Amsterdam; Rob Vandebriel; Tjeerd G Kimman; Hans Rümke; P S Steerenberg; Joseph G Vos
Vaccine-induced antibody responses as parameters of the influence of endogenous and environmental factors.
Environmental health perspectives 2001;109(8):757-64.
2000: Rob Vandebriel; C Meredith; M P Scott; M van Dijk; Henk Van Loveren
Interleukin-10 is an unequivocal Th2 parameter in the rat, whereas interleukin-4 is not.
Scandinavian journal of immunology 2000;52(5):519-24.
2000: François M M Van Och; Wout Slob; Wim H De Jong; Rob Vandebriel; Henk Van Loveren
A quantitative method for assessing the sensitizing potency of low molecular weight chemicals using a local lymph node assay: employment of a regression method that includes determination of the uncertainty margins.
Toxicology 2000;146(1):49-59.
2000: Rob Vandebriel; Wim H De Jong; S. Spiekstra; M Van Dijk; A Fluitman; Johan Garssen; Henk Van Loveren
Assessment of preferential T-helper 1 or T-helper 2 induction by low molecular weight compounds using the local lymph node assay in conjunction with RT-PCR and ELISA for interferon-gamma and interleukin-4.
Toxicology and applied pharmacology 2000;162(2):77-85.
1999: Peter A Steerenberg; J G C van Amsterdam; Rob Vandebriel; Joseph G Vos; Leendert van Bree; Henk Van Loveren
Environmental and lifestyle factors may act in concert to increase the prevalence of respiratory allergy including asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1999;29(10):1303-8.
1999: Rob Vandebriel; S. Spiekstra; BN Hudspith; C Meredith; Henk Van Loveren
In vitro exposure effects of cyclosporin A and bis(tri-n-butyltin)oxide on lymphocyte proliferation, cytokine (receptor) mRNA expression, and cell surface marker expression in rat thymocytes and splenocytes.
Toxicology 1999;135(1):49-66.
1999: Johan Garssen; Rob Vandebriel; Frank R de Gruijl; D A Wolvers; M Van Dijk; A Fluitman; Henk Van Loveren
UVB exposure-induced systemic modulation of Th1- and Th2-mediated immune responses.
Immunology 1999;97(3):506-14.
1998: Henk Van Loveren; Wim H De Jong; Rob Vandebriel; Joseph G Vos; Johan Garssen
Risk assessment and immunotoxicology.
Toxicology letters 1998;102-103():261-5.
1998: Rob Vandebriel; Henk Van Loveren; C Meredith
Altered cytokine (receptor) mRNA expression as a tool in immunotoxicology.
Toxicology 1998;130(1):43-67.
1998: Rob Vandebriel; C Meredith; M P Scott; Paul Roholl; Henk Van Loveren
Effects of in vivo exposure to bis(tri-n-butyltin)oxide, hexachlorobenzene, and benzo(a)pyrene on cytokine (receptor) mRNA levels in cultured rat splenocytes and on IL-2 receptor protein levels.
Toxicology and applied pharmacology 1998;148(1):126-36.
1998: Henk Van Loveren; Wout Slob; Rob Vandebriel; BN Hudspith; C Meredith; Johan Garssen
Immunotoxicology: extrapolation from animal to man--estimation of the immunotoxicologic risk associated with TBTO exposure.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1998;20():285-92.
1997: Johan Garssen; Rob Vandebriel; Henk Van Loveren
Molecular aspects of UVB-induced immunosuppression.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1997;19():97-109.
1996: Rob Vandebriel; C Meredith; M P Scott; E Gleichmann; N Bloksma; E H Van't Erve; J Descotes; Henk Van Loveren; H Ott
Early indicators of immunotoxicity: development of molecular biological test batteries.
Human & experimental toxicology 1996;15 Suppl 1():S1, S2-10.
1995: Rob Vandebriel; M van der Kolk; L Geerse; Peter A Steerenberg; M R Krul
A helper T-cell epitope of the E7 protein of human papillomavirus type 16 in BALB/c mice.
Virus research 1995;37(1):13-22.
1994: Rob Vandebriel; Roel A de Weger; Henk Van Loveren; Johan Garssen; Mireille van Poppel; Dick F van Wichen; Willem Den Otter
Specific T-cell factors that initiate cellular immune responses are produced by CD4-, CD8-, V beta 8- lymphocytes and are present in nude mice.
Cellular immunology 1994;159(1):1-14.
1992: Rob Vandebriel; Dick F van Wichen; Mireille van Poppel; M Robertus-Teunissen; D Zimmermann; H C Korswagen; N E Van Emmerik; Roel A de Weger
Specific T-cell factor production and lymphocytes in the direct surroundings of a subcutaneous allogeneic tumor.
Cellular immunology 1992;144(2):269-86.
1989: Rob Vandebriel; R A De Weger; Gerrit Los; H Van Loveren; G J Wiegers; P A Oude Weernink; Willem Den Otter
Two specific T cell factors that initiate immune responses in murine allograft systems. A comparison of biologic functions.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(1):66-73.
1989: J W De Groot; R A De Weger; Rob Vandebriel; W Den Otter
Differences in the induction of macrophage cytotoxicity by the specific T lymphocyte factor, specific macrophage arming factor (SMAF), and the lymphokine, macrophage activating factor (MAF).
Immunobiology 1989;179(2-3):131-44.
1989: Hub F J Dullens; Roel A de Weger; M Van der Maas; P J Den Besten; Rob Vandebriel; Willem Den Otter
Production of specific macrophage-arming factor precedes cytotoxic T lymphocyte activity in vivo during tumor rejection.
Cancer immunology, immunotherapy : CII 1989;30(1):28-33.
1989: Roel A de Weger; Rob Vandebriel; H Slager; D Mans; Henk Van Loveren; berry wilbrink; Hub F J Dullens; Willem Den Otter
Initial immunochemical characterization of specific macrophage-arming factor.
Cancer immunology, immunotherapy : CII 1989;30(1):21-7.
1989: Roel A de Weger; Henk Van Loveren; Rob Vandebriel; H K Parmentier
Sequential activity of gamma-delta T-cell receptor bearing lymphocytes, specific T-cell factors, and alpha-beta T-cell receptor bearing T-cells: a hypothesis.
Thymus 1989;14(1-3):19-29.