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Qing-Yu He

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Tong Wang; Xingfeng Yin; Yizhi Cui; Jiahui Guo; Qing-Yu He; Jingjie Jin; Guibin Wang; Gong Zhang
Translating mRNAs strongly correlate to proteins in a multivariate manner and their translation ratios are phenotype specific.
Chuan-Le Xiao; Gong Zhang; Xiao-Zhou Chen; Yang-Li Du; Xuesong Sun; Qing-Yu He
Binomial probability distribution model-based protein identification algorithm for tandem mass spectrometry utilizing peak intensity information.
Chuan-Le Xiao; Gong Zhang; Xiao-Zhou Chen; Yang-Li Du; Zhe-Fu Li; Li Wei; Qing-Yu He
Dispec: a novel Peptide scoring algorithm based on Peptide matching discriminability.

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2013: Tong Wang; Xingfeng Yin; Yizhi Cui; Jiahui Guo; Qing-Yu He; Jingjie Jin; Guibin Wang; Gong Zhang
Translating mRNAs strongly correlate to proteins in a multivariate manner and their translation ratios are phenotype specific.
Nucleic acids research 2013;41(9):4743-54.
2013: Chuan-Le Xiao; Gong Zhang; Xiao-Zhou Chen; Yang-Li Du; Xuesong Sun; Qing-Yu He
Binomial probability distribution model-based protein identification algorithm for tandem mass spectrometry utilizing peak intensity information.
Journal of proteome research 2013;12(1):328-35.
2013: Chuan-Le Xiao; Gong Zhang; Xiao-Zhou Chen; Yang-Li Du; Zhe-Fu Li; Li Wei; Qing-Yu He
Dispec: a novel Peptide scoring algorithm based on Peptide matching discriminability.
PloS one 2013;8(5):e62724.
2013: Yong-Yang Zhu; Yu-Qiang Wang; Zheng Xu; Guang-Rong Yan; Guangchuang Yu; Ye Zhang; Qing-Yu He
A novel andrographolide derivative AL-1 exerts its cytotoxicity on K562 cells through a ROS-dependent mechanism.
Proteomics 2013;13(1):169-78.
2012: Guang-Rong Yan; Guangchuang Yu; Ye Zhang; Fei-Yan Zou; Bian-Li Dang; Xiao Liu; Qing-Yu He
Genistein-induced mitotic arrest of gastric cancer cells by downregulating KIF20A, a proteomics study.
Proteomics 2012;12(14):2391-9.
2012: Guangchuang Yu; Li-Gen Wang; Yanyan Han; Qing-Yu He
clusterProfiler: an R package for comparing biological themes among gene clusters.
Omics : a journal of integrative biology 2012;16(5):284-7.
2012: Xiaoxin Yang; Yongguang Yang; Wenjie Zheng; Lanmei Chen; Tianfeng Chen; Jie Liu; Yanan Liu; Qing-Yu He
Ruthenium methylimidazole complexes induced apoptosis in lung cancer A549 cells through intrinsic mitochondrial pathway.
Biochimie 2012;94(2):345-53.
2012: Guangchuang Yu; Xiao-Hua Meng; Li-Gen Wang; Qing-Yu He
LXtoo: an integrated live Linux distribution for the bioinformatics community.
BMC research notes 2012;5():360.
2011: Yang Xu; Yuan Zhou; Feng Chen; Yick-Pang Ching; Jen-Fu Chiu; Qing-Yu He
Multiple pathways were involved in tubeimoside-1-induced cytotoxicity of HeLa cells.
Journal of proteomics 2011;75(2):491-501.
2011: Qihao Zhang; Ping Zou; Taoli Dai; Hao Hu; Yadong Huang; Xia Liu; Zhijian Su; Qi Xiang; Xue Xiao; Lei Zhang; Minjing Zhang; Qing-Yu He
Identification of potential biomarkers for predicting acute dermal irritation by proteomic analysis.
Journal of applied toxicology : JAT 2011;31(8):762-72.
2011: Xuesong Sun; Chuan-Le Xiao; Xiao-Yan Yang; Xing-Feng Yin; Guangchuang Yu; Xiang He; Qing-Yu He
Proteomic analysis of membrane proteins from Streptococcus pneumoniae with multiple separation methods plus high accuracy mass spectrometry.
Omics : a journal of integrative biology 2011;15(10):683-94.
2011: Guang-Rong Yan; Xin-Feng Yin; Zi-Lu Tan; Song-Hui Xu; Qing-Yu He
Proteomics characterization of gastrokine 1-induced growth inhibition of gastric cancer cells.
Proteomics 2011;11(18):3657-64.
2011: Xuesong Sun; Chuan-le Xiao; Xiaoyan Yang; Xingfeng Yin; Ying Zhu; Ruiguang Ge; Xiang He; Hui Li; Nan Li; Qing-Yu He
Putative copper- and zinc-binding motifs in Streptococcus pneumoniae identified by immobilized metal affinity chromatography and mass spectrometry.
Proteomics 2011;11(16):3288-98.
2011: Xuesong Sun; Chuan-Le Xiao; Xiao-Yan Yang; Xing-Feng Yin; Xiang He; Hong-Ling Jia; Hui Li; Nan Li; Jie Lu; Qing-Yu He
Bacterial proteome of streptococcus pneumoniae through multidimensional separations coupled with LC-MS/MS.
Omics : a journal of integrative biology 2011;15(7-8):477-82.
2011: Guang-Rong Yan; Song-Hui Xu; Zi-Lu Tan; Langxia Liu; Qing-Yu He
Global identification of miR-373-regulated genes in breast cancer by quantitative proteomics.
Proteomics 2011;11(5):912-20.
2011: Li-Ping Li; Chun-Hua Lu; Zhi-Peng Chen; Feng Ge; Tong Wang; Wei Wang; Chuan-Le Xiao; Xin-Feng Yin; Langxia Liu; Jian-Xing He; Qing-Yu He
Subcellular proteomics revealed the epithelial-mesenchymal transition phenotype in lung cancer.
Proteomics 2011;11(3):429-39.
2011: Guangchuang Yu; Chuan-Le Xiao; Chun-Hua Lu; Hai-Tao Jia; Feng Ge; Wei Wang; Xing-Feng Yin; Hong-Ling Jia; Jian-Xing He; Qing-Yu He
Phosphoproteome profile of human lung cancer cell line A549.
Molecular bioSystems 2011;7(2):472-9.
2011: Guangchuang Yu; Qing-Yu He
Functional similarity analysis of human virus-encoded miRNAs.
Journal of clinical bioinformatics 2011;1(1):15.
2011: Guang-Rong Yan; Wen Ding; Song-Hui Xu; Zhen Xu; Chuan-Le Xiao; Xing-Feng Yin; Qing-Yu He
Characterization of phosphoproteins in gastric cancer secretome.
Omics : a journal of integrative biology 2011;15(1-2):83-90.
2010: Xuesong Sun; Ruiguang Ge; Dongmei Zhang; Hongzhe Sun; Qing-Yu He
Iron-containing lipoprotein SiaA in SiaABC, the primary heme transporter of Streptococcus pyogenes.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2010;15(8):1265-73.
2010: Zhen Cai; Qian Wang; Yuan Zhou; Lei Zheng; Jen-Fu Chiu; Qing-Yu He
Epidermal growth factor-induced epithelial-mesenchymal transition in human esophageal carcinoma cells--a model for the study of metastasis.
Cancer letters 2010;296(1):88-95.
2010: Qihao Zhang; Lei Zhang; Xue Xiao; Zhijian Su; Ping Zou; Hao Hu; Yadong Huang; Qing-Yu He
Heavy metals chromium and neodymium reduced phosphorylation level of heat shock protein 27 in human keratinocytes.
Toxicology in vitro : an international journal published in association with BIBRA 2010;24(4):1098-104.
2010: Guang-Rong Yan; Chuan-Le Xiao; Gui-Wei He; Xing-Feng Yin; Nan-Peng Chen; Ya Cao; Qing-Yu He
Global phosphoproteomic effects of natural tyrosine kinase inhibitor, genistein, on signaling pathways.
Proteomics 2010;10(5):976-86.
2010: Feng Ge; Chuan-Le Xiao; Li-Jun Bi; Sheng-Ce Tao; Sheng Xiong; Xin-Feng Yin; Li-Ping Li; Chun-Hua Lu; Hai-Tao Jia; Qing-Yu He
Quantitative phosphoproteomics of proteasome inhibition in multiple myeloma cells.
PloS one 2010;5(9):.
2010: Xuesong Sun; Feng Ge; Chuan-Le Xiao; Xing-Feng Yin; Ruiguang Ge; Liu-Hui Zhang; Qing-Yu He
Phosphoproteomic analysis reveals the multiple roles of phosphorylation in pathogenic bacterium Streptococcus pneumoniae.
Journal of proteome research 2010;9(1):275-82.
2010: Ka-Wing Cheng; Chi-Chun Wong; Mingfu Wang; Qing-Yu He; Feng Chen
Identification and characterization of molecular targets of natural products by mass spectrometry.
Mass spectrometry reviews 2010;29(1):126-55.
2009: Bin Li; Sai Wah Tsao; Yuk Yin Li; Xianghong Wang; Ming-Tat Ling; Yong Chuan Wong; Qing-Yu He; Annie L M Cheung
Id-1 promotes tumorigenicity and metastasis of human esophageal cancer cells through activation of PI3K/AKT signaling pathway.
International journal of cancer. Journal international du cancer 2009;125(11):2576-85.
2009: Xuesong Sun; Heather M Baker; Ruiguang Ge; Hongzhe Sun; Qing-Yu He; Edward N Baker
Crystal structure and metal binding properties of the lipoprotein MtsA, responsible for iron transport in Streptococcus pyogenes.
Biochemistry 2009;48(26):6184-90.
2009: Xuesong Sun; Ruiguang Ge; Zongwei Cai; Hongzhe Sun; Qing-Yu He
Iron depletion decreases proliferation and induces apoptosis in a human colonic adenocarcinoma cell line, Caco2.
Journal of inorganic biochemistry 2009;103(7):1074-81.
2009: Lin Jin; Chuan-Le Xiao; Chun-Hua Lu; Min Xia; Guo-Wen Xing; Sheng Xiong; Qiu-Ying Liu; Hui Liu; Yi-Cheng Li; Feng Ge; Qing-Duan Wang; Qing-Yu He; Yi-Fei Wang
Transcriptomic and proteomic approach to studying SNX-2112-induced K562 cells apoptosis and anti-leukemia activity in K562-NOD/SCID mice.
FEBS letters 2009;583(12):1859-66.
2009: Feng Ge; Xin-Peng Lu; Hui-Lan Zeng; Qing-Yu He; Sheng Xiong; Lin Jin; Qing-Yu He
Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells.
Journal of proteome research 2009;8(6):3006-19.
2009: Lin Jin; Ge Liu; Chuan-hai Zhang; Chun-hua Lu; Sheng Xiong; Mei-ying Zhang; Qiu-Ying Liu; Feng Ge; Qing-Yu He; Kaio Kitazato; Nobuyuki Kobayashi; Yi-Fei Wang
Nm23-H1 regulates the proliferation and differentiation of the human chronic myeloid leukemia K562 cell line: a functional proteomics study.
Life sciences 2009;84(13-14):458-67.
2009: Yang Xu; Jen-Fu Chiu; Qing-Yu He; Feng Chen
Tubeimoside-1 exerts cytotoxicity in HeLa cells through mitochondrial dysfunction and endoplasmic reticulum stress pathways.
Journal of proteome research 2009;8(3):1585-93.
2009: Feng Ge; Qing-Yu He
Genomic and proteomic approaches for predicting toxicity and adverse drug reactions.
Expert opinion on drug metabolism & toxicology 2009;5(1):29-37.
2009: Zhen Cai; Yuan Zhou; Ting Lei; Jen-Fu Chiu; Qing-Yu He
Mammary serine protease inhibitor inhibits epithelial growth factor-induced epithelial-mesenchymal transition of esophageal carcinoma cells.
Cancer 2009;115(1):36-48.
2008: B H Y Yeung; B W Y Kwan; Qing-Yu He; A S Lee; Jie Liu; Alice S T Wong
Glucose-regulated protein 78 as a novel effector of BRCA1 for inhibiting stress-induced apoptosis.
Oncogene 2008;27(53):6782-9.
2008: Qing-Yu He; Huaiyi Yang; Benjamin C Y Wong; Jen-Fu Chiu
Serological proteomics of gastritis: degradation of apolipoprotein A-I and alpha1-antitrypsin is a common response to inflammation irrespective of Helicobacter pylori infection.
Digestive diseases and sciences 2008;53(12):3112-8.
2008: Fung Ming Siu; Dik-Lung Ma; Yee-Wai Cheung; Chun-Nam Lok; Kun Yan; Zhiqi Yang; Mengsu Yang; SongXiao Xu; Ben Chi-Bun Ko; Qing-Yu He; Chi-Ming Che
Proteomic and transcriptomic study on the action of a cytotoxic saponin (Polyphyllin D): induction of endoplasmic reticulum stress and mitochondria-mediated apoptotic pathways.
Proteomics 2008;8(15):3105-17.
2008: G-R Yan; Qing-Yu He
Functional proteomics to identify critical proteins in signal transduction pathways.
Amino acids 2008;35(2):267-74.
2008: Ying Wang; Qing-Yu He; Sai Wah Tsao; Yim-Hing Cheung; Anita Wong; Jen-Fu Chiu
Cytokeratin 8 silencing in human nasopharyngeal carcinoma cells leads to cisplatin sensitization.
Cancer letters 2008;265(2):188-96.
2008: Ting Lei; Qing-Yu He; Zhen Cai; Yuan Zhou; Yi-Li Wang; Lu-Sheng Si; Zongwei Cai; Jen-Fu Chiu
Proteomic analysis of chromium cytotoxicity in cultured rat lung epithelial cells.
Proteomics 2008;8(12):2420-9.
2008: Yuan Zhou; Inderjeet Bhatia; Zhen Cai; Qing-Yu He; Pik-To Cheung; Jen-Fu Chiu
Proteomic analysis of neonatal mouse brain: evidence for hypoxia- and ischemia-induced dephosphorylation of collapsin response mediator proteins.
Journal of proteome research 2008;7(6):2507-15.
2008: Chi Chun Wong; Ying Wang; Ka-Wing Cheng; Jen-Fu Chiu; Qing-Yu He; Feng Chen
Comparative proteomic analysis of indioside D-triggered cell death in HeLa cells.
Journal of proteome research 2008;7(5):2050-8.
2008: Xuesong Sun; Ruiguang Ge; Jen-Fu Chiu; Hongzhe Sun; Qing-Yu He
Lipoprotein MtsA of MtsABC in Streptococcus pyogenes primarily binds ferrous ion with bicarbonate as a synergistic anion.
FEBS letters 2008;582(9):1351-4.
2008: Ying Wang; Qing-Yu He; Chi-Ming Che; Sai Wah Tsao; Raymond Wai-Yin Sun; Jen-Fu Chiu
Modulation of gold(III) porphyrin 1a-induced apoptosis by mitogen-activated protein kinase signaling pathways.
Biochemical pharmacology 2008;75(6):1282-91.
2008: Chi Chun Wong; Ka Wing Cheng; Qing-Yu He; Feng Chen
Unraveling the molecular targets of natural products: Insights from genomic and proteomic analyses.
Proteomics. Clinical applications 2008;2(3):338-54.
2008: Qing-Yu He; Rui Zhu; Ting Lei; Mandy Y M Ng; John Luk; Pak Sham; George K K Lau; Jen-Fu Chiu
Toward the proteomic identification of biomarkers for the prediction of HBV related hepatocellular carcinoma.
Journal of cellular biochemistry 2008;103(3):740-52.
2008: Ting Lei; Qing-Yu He; Yi-Li Wang; Lü-sheng Si; Jen-Fu Chiu
Heparin chromatography to deplete high-abundance proteins for serum proteomics.
Clinica chimica acta; international journal of clinical chemistry 2008;388(1-2):173-8.
2008: Ying Wang; Jen-Fu Chiu; Qing-Yu He
Isolation of cytoplasmatic proteins from cultured cells for two-dimensional gel electrophoresis.
Methods in molecular biology (Clifton, N.J.) 2008;425():101-12.
2008: Sheng Xiong; Ling Zhang; Qing-Yu He
Fractionation of proteins by heparin chromatography.
Methods in molecular biology (Clifton, N.J.) 2008;424():213-21.
2008: Xuesong Sun; Jen-Fu Chiu; Qing-Yu He
Fractionation of proteins by immobilized metal affinity chromatography.
Methods in molecular biology (Clifton, N.J.) 2008;424():205-12.
2008: Xuesong Sun; Ruiguang Ge; Jen-Fu Chiu; Hongzhe Sun; Qing-Yu He
Identification of Proteins Related to Nickel Homeostasis in Helicobater pylori by Immobilized Metal Affinity Chromatography and Two-Dimensional Gel Electrophoresis.
Metal-based drugs 2008;2008():289490.
2007: Ying Wang; Chi-Ming Che; Jen-Fu Chiu; Qing-Yu He
Dioscin (saponin)-induced generation of reactive oxygen species through mitochondria dysfunction: a proteomic-based study.
Journal of proteome research 2007;6(12):4703-10.
2007: Ruiguang Ge; Xuesong Sun; Qing Gu; Rory Munro Watt; Julian Tanner; Benjamin Chun-Yu Wong; Harry Huaxiang Xia; Jian-Dong Huang; Qing-Yu He; Hongzhe Sun
A proteomic approach for the identification of bismuth-binding proteins in Helicobacter pylori.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2007;12(6):831-42.
2007: Amy Lo; Alvin K H Cheung; Victor K L Hung; Chung-Man Yeung; Qing-Yu He; Jen-Fu Chiu; Stephen S M Chung; Sookja K Chung
Deletion of aldose reductase leads to protection against cerebral ischemic injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2007;27(8):1496-509.
2007: Chun-Nam Lok; Chi-Ming Ho; Rong Chen; Qing-Yu He; Wing-Yiu Yu; Hongzhe Sun; Paul K H Tam; Jen-Fu Chiu; Chi-Ming Che
Silver nanoparticles: partial oxidation and antibacterial activities.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2007;12(4):527-34.
2007: Ying Wang; Qing-Yu He; Hongming Chen; Jen-Fu Chiu
Synergistic effects of retinoic acid and tamoxifen on human breast cancer cells: proteomic characterization.
Experimental cell research 2007;313(2):357-68.
2007: Ying Wang; Qing-Yu He; Raymond Wai-Yin Sun; Chi-Ming Che; Jen-Fu Chiu
Cellular pharmacological properties of gold(III) porphyrin 1a, a potential anticancer drug lead.
European journal of pharmacology 2007;554(2-3):113-22.
2006: Ruiguang Ge; Yi Zhang; Xuesong Sun; Rory Munro Watt; Qing-Yu He; Jian-Dong Huang; Dean E Wilcox; Hongzhe Sun
Thermodynamic and kinetic aspects of metal binding to the histidine-rich protein, Hpn.
Journal of the American Chemical Society 2006;128(35):11330-1.
2006: Ying Wang; Jen-Fu Chiu; Qing-Yu He
Proteomics approach to illustrate drug action mechanisms.
Current drug discovery technologies 2006;3(3):199-209.
2006: Chun-Nam Lok; Chi-Ming Ho; Rong Chen; Qing-Yu He; Wing-Yiu Yu; Hongzhe Sun; Paul K H Tam; Jen-Fu Chiu; Chi-Ming Che
Proteomic analysis of the mode of antibacterial action of silver nanoparticles.
Journal of proteome research 2006;5(4):916-24.
2006: Ying Wang; Yim Hing Cheung; Zhiqi Yang; Jen-Fu Chiu; Chi-Ming Che; Qing-Yu He
Proteomic approach to study the cytotoxicity of dioscin (saponin).
Proteomics 2006;6(8):2422-32.
2006: Ying Wang; Qing-Yu He; Chi-Ming Che; Jen-Fu Chiu
Proteomic characterization of the cytotoxic mechanism of gold (III) porphyrin 1a, a potential anticancer drug.
Proteomics 2006;6(1):131-42.
2006: Ruiguang Ge; Rory Munro Watt; Xuesong Sun; Julian Tanner; Qing-Yu He; Jian-Dong Huang; Hongzhe Sun
Expression and characterization of a histidine-rich protein, Hpn: potential for Ni2+ storage in Helicobacter pylori.
The Biochemical journal 2006;393(Pt 1):285-93.
2005: Ying Wang; Qing-Yu He; Raymond Wai-Yin Sun; Chi-Ming Che; Jen-Fu Chiu
GoldIII porphyrin 1a induced apoptosis by mitochondrial death pathways related to reactive oxygen species.
Cancer research 2005;65(24):11553-64.
2005: Xuesong Sun; Jen-Fu Chiu; Qing-Yu He
Application of immobilized metal affinity chromatography in proteomics.
Expert review of proteomics 2005;2(5):649-57.
2005: Qing-Yu He; Yuan Zhou; Esther Wong; Thomas G Ehlen; Nelly Auersperg; Jen-Fu Chiu; Alice S T Wong
Proteomic analysis of a preneoplastic phenotype in ovarian surface epithelial cells derived from prophylactic oophorectomies.
Gynecologic oncology 2005;98(1):68-76.
2005: Pei-Hui Yang; Xuesong Sun; Jen-Fu Chiu; Hongzhe Sun; Qing-Yu He
Transferrin-mediated gold nanoparticle cellular uptake.
Bioconjugate chemistry 2005;16(3):494-6.
2005: Qing-Yu He; Rui Zhu; Yi Ren; Paul K H Tam; Jen-Fu Chiu
Serological protein profiling of neuroblastoma by ProteinChip SELDI-TOF technology.
Journal of cellular biochemistry 2005;95(1):165-72.
2005: Hongyan Li; Fei Li; Miufan Kwan; Qing-Yu He; Hongzhe Sun
NMR structures and orientation of the fourth transmembrane domain of the rat divalent metal transporter (DMT1) with G185D mutation in SDS micelles.
Biopolymers 2005;77(4):173-83.
2005: Fei Li; Hongyan Li; Lihong Hu; Miufan Kwan; Guanhua Chen; Qing-Yu He; Hongzhe Sun
Structure, assembly, and topology of the G185R mutant of the fourth transmembrane domain of divalent metal transporter.
Journal of the American Chemical Society 2005;127(5):1414-23.
2004: Yi Ren; Qing-Yu He; Jianqing Fan; Brian Jones; Yuan Zhou; Yi Xie; Chung-Yan Cheung; Adrian Wu; Jen-Fu Chiu; J S M Peiris; Paul K H Tam
The use of proteomics in the discovery of serum biomarkers from patients with severe acute respiratory syndrome.
Proteomics 2004;4(11):3477-84.
2004: Andy T Y Lau; Qing-Yu He; Jen-Fu Chiu
A proteome analysis of the arsenite response in cultured lung cells: evidence for in vitro oxidative stress-induced apoptosis.
The Biochemical journal 2004;382(Pt 2):641-50.
2004: Xuesong Sun; Hongzhe Sun; Ruiguang Ge; Megan Richter; Robert C Woodworth; Anne Mason; Qing-Yu He
The low pKa value of iron-binding ligand Tyr188 and its implication in iron release and anion binding of human transferrin.
FEBS letters 2004;573(1-3):181-5.
2004: Zhen Cai; Jen-Fu Chiu; Qing-Yu He
Application of proteomics in the study of tumor metastasis.
Genomics, proteomics & bioinformatics 2004;2(3):152-66.
2004: Jia Chen; Qing-Yu He; Anthony Po-Wing Yuen; Jen-Fu Chiu
Proteomics of buccal squamous cell carcinoma: the involvement of multiple pathways in tumorigenesis.
Proteomics 2004;4(8):2465-75.
2004: Yin-Lau Lee; Kai-Fai Lee; Jia-Sen Xu; Qing-Yu He; Jen-Fu Chiu; Will M Lee; John Luk; William S B Yeung
The embryotrophic activity of oviductal cell-derived complement C3b and iC3b, a novel function of complement protein in reproduction.
The Journal of biological chemistry 2004;279(13):12763-8.
2004: Qing-Yu He; Jia Chen; Hsiang-Fu Kung; Anthony Po-Wing Yuen; Jen-Fu Chiu
Identification of tumor-associated proteins in oral tongue squamous cell carcinoma by proteomics.
Proteomics 2004;4(1):271-8.
2004: Andy T Y Lau; Muyao Li; Ronglin Xie; Qing-Yu He; Jen-Fu Chiu
Opposed arsenite-induced signaling pathways promote cell proliferation or apoptosis in cultured lung cells.
Carcinogenesis 2004;25(1):21-8.
2003: Andy T Y Lau; Qing-Yu He; Jen-Fu Chiu
Proteomic technology and its biomedical applications.
Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica 2003;35(11):965-75.
2003: Qing-Yu He; Jen-Fu Chiu
Proteomics in biomarker discovery and drug development.
Journal of cellular biochemistry 2003;89(5):868-86.
2003: Qing-Yu He; Robert C Woodworth; N Dennis Chasteen
Anion exchange in human serum transferrin N-lobe: a model study with variant His249Ala.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2003;8(6):635-43.
2003: Heather M Baker; Qing-Yu He; Sara K Briggs; Anne Mason; Edward N Baker
Structural and functional consequences of binding site mutations in transferrin: crystal structures of the Asp63Glu and Arg124Ala mutants of the N-lobe of human transferrin.
Biochemistry 2003;42(23):7084-9.
2003: Qing-Yu He; George K K Lau; Yuan Zhou; Siu Tsan Yuen; Marie C Lin; Hsiang-Fu Kung; Jen-Fu Chiu
Serum biomarkers of hepatitis B virus infected liver inflammation: a proteomic study.
Proteomics 2003;3(5):666-74.
2003: Peter J Halbrooks; Qing-Yu He; Sara K Briggs; Stephen J Everse; Valerie C Smith; Ross T A MacGillivray; Anne Mason
Investigation of the mechanism of iron release from the C-lobe of human serum transferrin: mutational analysis of the role of a pH sensitive triad.
Biochemistry 2003;42(13):3701-7.
2003: Ty E Adams; Anne Mason; Qing-Yu He; Peter J Halbrooks; Sara K Briggs; Valerie C Smith; Ross T A MacGillivray; Stephen J Everse
The position of arginine 124 controls the rate of iron release from the N-lobe of human serum transferrin. A structural study.
The Journal of biological chemistry 2003;278(8):6027-33.
2003: Qing-Yu He; Ta-Tung Yip; Muyao Li; Jen-Fu Chiu
Proteomic analyses of arsenic-induced cell transformation with SELDI-TOF ProteinChip technology.
Journal of cellular biochemistry 2003;88(1):1-8.
2002: Anne Mason; Qing-Yu He; Peter J Halbrooks; Stephen J Everse; Dmitry R Gumerov; Igor A Kaltashov; Valerie C Smith; Jeff Hewitt; Ross T A MacGillivray
Differential effect of a his tag at the N- and C-termini: functional studies with recombinant human serum transferrin.
Biochemistry 2002;41(30):9448-54.
2001: Heather M Baker; Anne Mason; Qing-Yu He; Ross T A MacGillivray; Edward N Baker
Ligand variation in the transferrin family: the crystal structure of the H249Q mutant of the human transferrin N-lobe as a model for iron binding in insect transferrins.
Biochemistry 2001;40(39):11670-5.
2001: Anne Mason; Qing-Yu He; Ty E Adams; Dmitry R Gumerov; Igor A Kaltashov; V Nguyen; Ross T A MacGillivray
Expression, purification, and characterization of recombinant nonglycosylated human serum transferrin containing a C-terminal hexahistidine tag.
Protein expression and purification 2001;23(1):142-50.
2001: Qing-Yu He; Anne Mason; Barbara A Lyons; BM Tam; V Nguyen; Ross T A MacGillivray; Robert C Woodworth
Spectral and metal-binding properties of three single-point tryptophan mutants of the human transferrin N-lobe.
The Biochemical journal 2001;354(Pt 2):423-9.
2001: Didier Nurizzo; Heather M Baker; Qing-Yu He; Ross T A MacGillivray; Anne Mason; Robert C Woodworth; Edward N Baker
Crystal structures and iron release properties of mutants (K206A and K296A) that abolish the dilysine interaction in the N-lobe of human transferrin.
Biochemistry 2001;40(6):1616-23.
2000: Qing-Yu He; Anne Mason; V Nguyen; Ross T A MacGillivray; Robert C Woodworth
The chloride effect is related to anion binding in determining the rate of iron release from the human transferrin N-lobe.
The Biochemical journal 2000;350 Pt 3():909-15.
2000: Ross T A MacGillivray; Maria C Bewley; Clyde Smith; Qing-Yu He; Anne Mason; Robert C Woodworth; Edward N Baker
Mutation of the iron ligand His 249 to Glu in the N-lobe of human transferrin abolishes the dilysine "trigger" but does not significantly affect iron release.
Biochemistry 2000;39(6):1211-6.
2000: Qing-Yu He; Anne Mason; R Pakdaman; N Dennis Chasteen; B K Dixon; BM Tam; V Nguyen; Ross T A MacGillivray; Robert C Woodworth
Mutations at the histidine 249 ligand profoundly alter the spectral and iron-binding properties of human serum transferrin N-lobe.
Biochemistry 2000;39(6):1205-10.
1999: Qing-Yu He; Anne Mason; BM Tam; Ross T A MacGillivray; Robert C Woodworth
[13C]Methionine NMR and metal-binding studies of recombinant human transferrin N-lobe and five methionine mutants: conformational changes and increased sensitivity to chloride.
The Biochemical journal 1999;344 Pt 3():881-7.
1999: M C Cox; Kevin J Barnham; T A Frenkiel; J D Hoeschele; Anne Mason; Qing-Yu He; Robert C Woodworth; Peter J Sadler
Identification of platination sites on human serum transferrin using (13)C and (15)N NMR spectroscopy.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 1999;4(5):621-31.
1999: Qing-Yu He; Anne Mason; BM Tam; Ross T A MacGillivray; Robert C Woodworth
Dual role of Lys206-Lys296 interaction in human transferrin N-lobe: iron-release trigger and anion-binding site.
Biochemistry 1999;38(30):9704-11.
1998: Qing-Yu He; Anne Mason; Robert C Woodworth; BM Tam; Ross T A MacGillivray; John K Grady; N Dennis Chasteen
Mutations at nonliganding residues Tyr-85 and Glu-83 in the N-lobe of human serum transferrin. Functional second shell effects.
The Journal of biological chemistry 1998;273(27):17018-24.
1998: A Mason; Qing-Yu He; BM Tam; R A MacGillivray; Robert C Woodworth
Mutagenesis of the aspartic acid ligands in human serum transferrin: lobe-lobe interaction and conformation as revealed by antibody, receptor-binding and iron-release studies.
The Biochemical journal 1998;330 ( Pt 1)():35-40.
1997: Qing-Yu He; Anne Mason; Robert C Woodworth; BM Tam; Ross T A MacGillivray; John K Grady; N Dennis Chasteen
Inequivalence of the two tyrosine ligands in the N-lobe of human serum transferrin.
Biochemistry 1997;36(48):14853-60.
1997: Qing-Yu He; Anne Mason; Robert C Woodworth
Iron release from recombinant N-lobe and single point Asp63 mutants of human transferrin by EDTA.
The Biochemical journal 1997;328 ( Pt 2)():439-45.
1997: Qing-Yu He; Anne Mason; Robert C Woodworth; BM Tam; T Wadsworth; Ross T A MacGillivray
Effects of mutations of aspartic acid 63 on the metal-binding properties of the recombinant N-lobe of human serum transferrin.
Biochemistry 1997;36(18):5522-8.
1997: E J Beatty; M C Cox; T A Frenkiel; Qing-Yu He; Anne Mason; P J Sadler; A Tucker; Robert C Woodworth
Trp128Tyr mutation in the N-lobe of recombinant human serum transferrin: 1H- and 15N-NMR and metal binding studies.
Protein engineering 1997;10(5):583-91.
1996: Qing-Yu He; Anne Mason; Robert C Woodworth
Spectrophotometric titration with cobalt(III) for the determination of accurate absorption coefficients of transferrins.
The Biochemical journal 1996;318 ( Pt 1)():145-8.