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Philip Hardwidge

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Rachel L Olsen; Dilyara Cheranova; Wanyin Deng; Frank Echtenkamp; B Brett Finlay; Philip R Hardwidge
The enterohemorrhagic Escherichia coli effector protein NleF binds mammalian Tmp21.
Xiaofei Gao; Leigh Ann Feuerbacher; Minzhao Huang; Marie-Luise Lubos; Arcady Mushegian; Rachel Olsen; Thanh H Pham; Chad Slawson; Xiaogang Wang; Philip R Hardwidge
NleB, a bacterial effector with glycosyltransferase activity, targets GAPDH function to inhibit NF-κB activation.
Mingxu Zhou; Xiaofang Zhu; Qiangde Duan; Zhiyan Guo; Philip R Hardwidge; Yinchau Li; Guoqiang Zhu
Both flagella and F4 fimbriae from F4ac+ enterotoxigenic Escherichia coli contribute to attachment to IPEC-J2 cells in vitro.

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All Publications

2013: Rachel L Olsen; Dilyara Cheranova; Wanyin Deng; Frank Echtenkamp; B Brett Finlay; Philip R Hardwidge
The enterohemorrhagic Escherichia coli effector protein NleF binds mammalian Tmp21.
Veterinary microbiology 2013;164(1-2):164-70.
2013: Xiaofei Gao; Leigh Ann Feuerbacher; Minzhao Huang; Marie-Luise Lubos; Arcady Mushegian; Rachel Olsen; Thanh H Pham; Chad Slawson; Xiaogang Wang; Philip R Hardwidge
NleB, a bacterial effector with glycosyltransferase activity, targets GAPDH function to inhibit NF-κB activation.
Cell host & microbe 2013;13(1):87-99.
2013: Mingxu Zhou; Xiaofang Zhu; Qiangde Duan; Zhiyan Guo; Philip R Hardwidge; Yinchau Li; Guoqiang Zhu
Both flagella and F4 fimbriae from F4ac+ enterotoxigenic Escherichia coli contribute to attachment to IPEC-J2 cells in vitro.
Veterinary research 2013;44(1):30.
2012: Xiaogang Wang; Philip R Hardwidge
Enterotoxigenic Escherichia coli prevents host NF-κB activation by targeting IκBα polyubiquitination.
Infection and immunity 2012;80(12):4417-25.
2012: Xiaogang Wang; Xiaofei Gao; Philip R Hardwidge
Heat-labile enterotoxin-induced activation of NF-κB and MAPK pathways in intestinal epithelial cells impacts enterotoxigenic Escherichia coli (ETEC) adherence.
Cellular microbiology 2012;14(8):1231-41.
2012: Thanh H Pham; Karen Tsai; Fengyi Wan; Xiaofei Gao; Rachel Olsen; Philip R Hardwidge
Functional differences and interactions between the Escherichia coli type III secretion system effectors NleH1 and NleH2.
Infection and immunity 2012;80(6):2133-40.
2011: Qiji Deng; Xiaofei Gao; Philip R Hardwidge; Radhey S Kaushik; Dan Wang; Thorsten Wolff; Xiaoxiao Xiang; Suvobrata Chakravarty; Feng Li
Application of a split luciferase complementation assay for the detection of viral protein-protein interactions.
Journal of virological methods 2011;176(1-2):108-11.
2011: Fengyi Wan; Amanda Weaver; Xiaofei Gao; Michael Bern; Philip R Hardwidge; Michael J Lenardo
IKKβ phosphorylation regulates RPS3 nuclear translocation and NF-κB function during infection with Escherichia coli strain O157:H7.
Nature immunology 2011;12(4):335-43.
2011: Qiji Deng; Dan Wang; Xiaoxiao Xiang; Xiaofei Gao; Philip R Hardwidge; Radhey Kaushik; Thorsten Wolff; Suvobrata Chakravarty; Feng Li
Nuclear localization of influenza B polymerase proteins and their binary complexes.
Virus research 2011;156(1-2):49-53.
2011: Xiaofei Gao; Philip R Hardwidge
Ribosomal protein s3: a multifunctional target of attaching/effacing bacterial pathogens.
Frontiers in microbiology 2011;2():137.
2010: Stephanie R Shames; Wanyin Deng; Julian A Guttman; Carmen L de Hoog; Yuling Li; Philip R Hardwidge; Ho Pan Sham; Bruce A Vallance; Leonard J Foster; B Brett Finlay
The pathogenic E. coli type III effector EspZ interacts with host CD98 and facilitates host cell prosurvival signalling.
Cellular microbiology 2010;12(9):1322-39.
2010: Amber M Johnson; Radhey S Kaushik; Philip R Hardwidge
Disruption of transepithelial resistance by enterotoxigenic Escherichia coli.
Veterinary microbiology 2010;141(1-2):115-9.
2010: James M Fleckenstein; Philip R Hardwidge; Munson George; David Rasko; Halvor Sommerfelt; Hans Steinsland
Molecular mechanisms of enterotoxigenic Escherichia coli infection.
Microbes and infection / Institut Pasteur 2010;12(2):89-98.
2009: Xiaofei Gao; Fengyi Wan; Kristina Mateo; Eduardo Callegari; Dan Wang; Wanyin Deng; Jose Puente; Feng Li; Michael S Chaussee; B Brett Finlay; Michael J Lenardo; Philip R Hardwidge
Bacterial effector binding to ribosomal protein s3 subverts NF-kappaB function.
PLoS pathogens 2009;5(12):e1000708.
2009: Xiaofei Gao; Amy Schutz-Geschwender; Philip R Hardwidge
Near-infrared fluorescence detection of ATP-biotin-mediated phosphoprotein labeling.
Biotechnology letters 2009;31(1):113-7.
2008: Frank Echtenkamp; Wanyin Deng; Mark E Wickham; Alejandra Vazquez; José Luis Puente; Ajitha Thanabalasuriar; Samantha Gruenheid; B Brett Finlay; Philip R Hardwidge
Characterization of the NleF effector protein from attaching and effacing bacterial pathogens.
FEMS microbiology letters 2008;281(1):98-107.
2007: Eric A Brown; Philip R Hardwidge
Biochemical characterization of the enterotoxigenic Escherichia coli LeoA protein.
Microbiology (Reading, England) 2007;153(Pt 11):3776-84.
2007: Diane R Baker; Rodney A Moxley; Mike B Steele; Jeffrey T Lejeune; Jane Christopher-Hennings; Ding-Geng Chen; Philip R Hardwidge; David H Francis
Differences in virulence among Escherichia coli O157:H7 strains isolated from humans during disease outbreaks and from healthy cattle.
Applied and environmental microbiology 2007;73(22):7338-46.
2007: Jinoh Kim; Ajitha Thanabalasuriar; Tessa Chaworth-Musters; J Christopher Fromme; Elizabeth A Frey; Paula Lario; Pavel Metalnikov; Keyrillos Rizg; Nikhil A Thomas; Sau Fung Lee; Elizabeth L Hartland; Philip R Hardwidge; Tony Pawson; Natalie C J Strynadka; B Brett Finlay; Randy Schekman; Samantha Gruenheid
The bacterial virulence factor NleA inhibits cellular protein secretion by disrupting mammalian COPII function.
Cell host & microbe 2007;2(3):160-71.
2007: Eric A Brown; Radhey S Kaushik; Philip R Hardwidge
Susceptibility of human enterotoxigenic Escherichia coli isolates to growth inhibition by porcine intestinal epithelial cells.
FEMS microbiology letters 2007;274(1):95-101.
2006: Philip R Hardwidge; Samuel Donohoe; Ruedi Aebersold; B Brett Finlay
Proteomic analysis of the binding partners to enteropathogenic Escherichia coli virulence proteins expressed in Saccharomyces cerevisiae.
Proteomics 2006;6(7):2174-9.
2005: Isabel Rodríguez-Escudero; Philip R Hardwidge; César Nombela; Víctor J Cid; B Brett Finlay; María Molina
Enteropathogenic Escherichia coli type III effectors alter cytoskeletal function and signalling in Saccharomyces cerevisiae.
Microbiology (Reading, England) 2005;151(Pt 9):2933-45.
2005: Micah J McCauley; Philip R Hardwidge; L James Maher; Mark C Williams
Dual binding modes for an HMG domain from human HMGB2 on DNA.
Biophysical journal 2005;89(1):353-64.
2005: Philip R Hardwidge; Wanyin Deng; Bruce A Vallance; Isabel Rodriguez-Escudero; Víctor J Cid; Maria Molina; B Brett Finlay
Modulation of host cytoskeleton function by the enteropathogenic Escherichia coli and Citrobacter rodentium effector protein EspG.
Infection and immunity 2005;73(5):2586-94.
2005: Wanyin Deng; Yuling Li; Philip R Hardwidge; Elizabeth A Frey; Richard A Pfuetzner; Sansan Lee; Samantha Gruenheid; Natalie C J Strynakda; José Luis Puente; B Brett Finlay
Regulation of type III secretion hierarchy of translocators and effectors in attaching and effacing bacterial pathogens.
Infection and immunity 2005;73(4):2135-46.
2004: Philip R Hardwidge; Isabel Rodriguez-Escudero; David Goode; Samuel Donohoe; Jimmy Eng; David R Goodlett; Ruedi Aebersold; B Brett Finlay
Proteomic analysis of the intestinal epithelial cell response to enteropathogenic Escherichia coli.
The Journal of biological chemistry 2004;279(19):20127-36.
2004: Brian K Coombes; Philip R Hardwidge; B Brett Finlay
Interpreting the host-pathogen dialogue through microarrays.
Advances in applied microbiology 2004;54():291-331.
2003: Philip R Hardwidge; Kay M Parkhurst; Lawrence J Parkhurst; L James Maher
Reflections on apparent DNA bending by charge variants of bZIP proteins.
Biopolymers 2003;69(1):110-7.
2002: Philip R Hardwidge; Jason D Kahn; L James Maher
Dominant effect of protein charge rather than protein shape in apparent DNA bending by engineered bZIP domains.
Biochemistry 2002;41(26):8277-88.
2002: Philip R Hardwidge; Jiong Wu; Sarah L Williams; Kay M Parkhurst; Lawrence J Parkhurst; L James Maher
DNA bending by bZIP charge variants: a unified study using electrophoretic phasing and fluorescence resonance energy transfer.
Biochemistry 2002;41(24):7732-42.
2002: Philip R Hardwidge; Jeff M Zimmerman; L James Maher
Charge neutralization and DNA bending by the Escherichia coli catabolite activator protein.
Nucleic acids research 2002;30(9):1879-85.
2001: Philip R Hardwidge; D K Lee; T P Prakash; B Iglesias; RB Den; C Switzer; L James Maher
DNA bending by asymmetrically tethered cations: influence of tether flexibility.
Chemistry & biology 2001;8(10):967-80.
2001: Eric D Ross; Philip R Hardwidge; L James Maher
HMG proteins and DNA flexibility in transcription activation.
Molecular and cellular biology 2001;21(19):6598-605.
2001: Philip R Hardwidge; L James Maher
Experimental evaluation of the Liu-Beveridge dinucleotide step model of DNA structure.
Nucleic acids research 2001;29(12):2619-25.
2000: Philip R Hardwidge; Jeff M Zimmerman; L James Maher
Design and calibration of a semi-synthetic DNA phasing assay.
Nucleic acids research 2000;28(23):E102.
2000: Philip R Hardwidge; RB Den; Eric D Ross; L James Maher
Relating independent measures of DNA curvature: electrophoretic anomaly and cyclization efficiency.
Journal of biomolecular structure & dynamics 2000;18(2):219-30.
1999: Eric D Ross; RB Den; Philip R Hardwidge; L James Maher
Improved quantitation of DNA curvature using ligation ladders.
Nucleic acids research 1999;27(21):4135-42.
1999: D R Hostetter; Gresham T Weatherly; J R Beasley; K Bortone; D S Cohen; S A Finger; Philip R Hardwidge; D S Kakouras; Aleister J Saunders; S K Trojak; JC Waldner; Gary J Pielak
Partially formed native tertiary interactions in the A-state of cytochrome c.
Journal of molecular biology 1999;289(3):639-44.