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David Gewirtz

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David Gewirtz
Autophagy and senescence: A partnership in search of definition.
Molly L Bristol; Xu Di; Zhen Fan; Scott C Henderson; Aparna Maiti; Eden N Wilson; Matthew J Beckman; David Gewirtz
Dual functions of autophagy in the response of breast tumor cells to radiation: cytoprotective autophagy with radiation alone and cytotoxic autophagy in radiosensitization by vitamin D 3.
Xu Di; Chris Gennings; Harry D Bear; Laura J Graham; Christopher M Sheth; Kimber L White; David Gewirtz
Influence of the phosphodiesterase-5 inhibitor, sildenafil, on sensitivity to chemotherapy in breast tumor cells.

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All Publications

2013: David Gewirtz
Autophagy and senescence: A partnership in search of definition.
Autophagy 2013;9(5):808-12.
2012: Molly L Bristol; Xu Di; Zhen Fan; Scott C Henderson; Aparna Maiti; Eden N Wilson; Matthew J Beckman; David Gewirtz
Dual functions of autophagy in the response of breast tumor cells to radiation: cytoprotective autophagy with radiation alone and cytotoxic autophagy in radiosensitization by vitamin D 3.
Autophagy 2012;8(5):739-53.
2010: Xu Di; Chris Gennings; Harry D Bear; Laura J Graham; Christopher M Sheth; Kimber L White; David Gewirtz
Influence of the phosphodiesterase-5 inhibitor, sildenafil, on sensitivity to chemotherapy in breast tumor cells.
Breast cancer research and treatment 2010;124(2):349-60.
2010: David Gewirtz; Molly L Bristol; Jack C Yalowich
Toxicity issues in cancer drug development.
Current opinion in investigational drugs (London, England : 2000) 2010;11(6):612-4.
2009: David Gewirtz
Autophagy, senescence and tumor dormancy in cancer therapy.
Autophagy 2009;5(8):1232-4.
2009: David Gewirtz; Molly L Hilliker; Eden N Wilson
Promotion of autophagy as a mechanism for radiation sensitization of breast tumor cells.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2009;92(3):323-8.
2009: Xiao Di; Robert P Shiu; Irene Newsham; David Gewirtz
Apoptosis, autophagy, accelerated senescence and reactive oxygen in the response of human breast tumor cells to adriamycin.
Biochemical pharmacology 2009;77(7):1139-50.
2008: David Gewirtz; Shawn E Holt; Lynne W Elmore
Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation.
Biochemical pharmacology 2008;76(8):947-57.
2008: David Gewirtz
The role of senescence in the action of antitumor drugs.
Current opinion in investigational drugs (London, England : 2000) 2008;9(6):562-4.
2008: Xu Di; Andrew Taylor Bright; Ricardo Bellott; Elizabeth Gaskins; Jacques Robert; Shawn Holt; David Gewirtz; Lynne W Elmore
A chemotherapy-associated senescence bystander effect in breast cancer cells.
Cancer biology & therapy 2008;7(6):864-72.
2008: Ashutosh Tripathi; Micaela Fornabaio; Glen E Kellogg; John T Gupton; David Gewirtz; W Andrew Yeudall; Nina E Vega; Susan Mooberry
Docking and hydropathic scoring of polysubstituted pyrrole compounds with antitubulin activity.
Bioorganic & medicinal chemistry 2008;16(5):2235-42.
2007: Christopher R Arthur; John T Gupton; Glen E Kellogg; W Andrew Yeudall; Myles C Cabot; Irene Newsham; David Gewirtz
Autophagic cell death, polyploidy and senescence induced in breast tumor cells by the substituted pyrrole JG-03-14, a novel microtubule poison.
Biochemical pharmacology 2007;74(7):981-91.
2007: Sheena M Aris; David Gewirtz; John J Ryan; Kenneth M Knott; Nicholas Farrell
Promotion of DNA strand breaks, interstrand cross-links and apoptotic cell death in A2780 human ovarian cancer cells by transplatinum planar amine complexes.
Biochemical pharmacology 2007;73(11):1749-57.
2007: David Gewirtz
Autophagy as a mechanism of radiation sensitization in breast tumor cells.
Autophagy 2007;3(3):249-50.
2006: Sujatha Sundaram; Matthew J Beckman; Amandeep Bajwa; Jeffrey Wei; Kathleen M Smith; Gary H Posner; David Gewirtz
QW-1624F2-2, a synthetic analogue of 1,25-dihydroxyvitamin D3, enhances the response to other deltanoids and suppresses the invasiveness of human metastatic breast tumor cells.
Molecular cancer therapeutics 2006;5(11):2806-14.
2006: Gerald A DeMasters; Xu Di; Irene Newsham; Robert Shiu; David Gewirtz
Potentiation of radiation sensitivity in breast tumor cells by the vitamin D3 analogue, EB 1089, through promotion of autophagy and interference with proliferative recovery.
Molecular cancer therapeutics 2006;5(11):2786-97.
2006: Quincy A Quick; David Gewirtz
Enhancement of radiation sensitivity, delay of proliferative recovery after radiation and abrogation of MAPK (p44/42) signaling by imatinib in glioblastoma cells.
International journal of oncology 2006;29(2):407-12.
2006: Quincy A Quick; David Gewirtz
An accelerated senescence response to radiation in wild-type p53 glioblastoma multiforme cells.
Journal of neurosurgery 2006;105(1):111-8.
2006: David Gewirtz; Xu Di; Teneille D Walker; Stephen T Sawyer
Erythropoietin fails to interfere with the antiproliferative and cytotoxic effects of antitumor drugs.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(7 Pt 1):2232-8.
2006: David Gewirtz
Caveolin and STAT-5 signaling: potential overlap in lactation and breast tumor promotion.
Cancer biology & therapy 2006;5(3):298-9.
2005: David Gewirtz; Lynne W Elmore
Apoptosis as the predominant tumor cell response to chemotherapy and irradiation: a case of TUNEL vision?
Current opinion in investigational drugs (London, England : 2000) 2005;6(12):1199.
2005: Kara R Jones; David Gewirtz; Steven M Yannone; Shaoming Zhou; David G Schatz; Kristoffer Valerie; Lawrence F Povirk
Radiosensitization of MDA-MB-231 breast tumor cells by adenovirus-mediated overexpression of a fragment of the XRCC4 protein.
Molecular cancer therapeutics 2005;4(10):1541-7.
2005: Kara R Jones; Lynne W Elmore; Colleen Jackson-Cook; Gerald A DeMasters; Lawrence F Povirk; Shawn E Holt; David Gewirtz
p53-Dependent accelerated senescence induced by ionizing radiation in breast tumour cells.
International journal of radiation biology 2005;81(6):445-58.
2005: Lynne W Elmore; Xu Di; Catherine I Dumur; Shawn E Holt; David Gewirtz
Evasion of a single-step, chemotherapy-induced senescence in breast cancer cells: implications for treatment response.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(7):2637-43.
2004: Gerald A DeMasters; Mona S Gupta; Kara R Jones; Myles C Cabot; Hongtao Wang; Chris Gennings; Misook Park; Ase Bratland; Anne Hansen Ree; David Gewirtz
Potentiation of cell killing by fractionated radiation and suppression of proliferative recovery in MCF-7 breast tumor cells by the Vitamin D3 analog EB 1089.
The Journal of steroid biochemistry and molecular biology 2004;92(5):365-74.
2004: Deepali K Hattangadi; Gerald A DeMasters; Teneille D Walker; Kara R Jones; Xu Di; Irene Newsham; David Gewirtz
Influence of p53 and caspase 3 activity on cell death and senescence in response to methotrexate in the breast tumor cell.
Biochemical pharmacology 2004;68(9):1699-708.
2004: Nicholas Farrell; Lawrence F Povirk; Yojana Dange; Gerald A DeMasters; Mona S Gupta; Glenda Kohlhagen; Qasim A Khan; Yves Pommier; David Gewirtz
Cytotoxicity, DNA strand breakage and DNA-protein crosslinking by a novel transplatinum compound in human A2780 ovarian and MCF-7 breast carcinoma cells.
Biochemical pharmacology 2004;68(5):857-66.
2003: Sujatha Sundaram; Andrea Sea; Stephanie Feldman; Rendall R Strawbridge; P Jack Hoopes; Eugene Demidenko; Lise Binderup; David Gewirtz
The combination of a potent vitamin D3 analog, EB 1089, with ionizing radiation reduces tumor growth and induces apoptosis of MCF-7 breast tumor xenografts in nude mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(6):2350-6.
2003: Mark K Polar; Chris Gennings; Misook Park; Mona S Gupta; David Gewirtz
Effect of the vitamin D3 analog ILX 23-7553 on apoptosis and sensitivity to fractionated radiation in breast tumor cells and normal human fibroblasts.
Cancer chemotherapy and pharmacology 2003;51(5):415-21.
2002: David Gewirtz; Mona S Gupta; Sujatha Sundaram
Vitamin D3 and vitamin D3 analogues as an adjunct to cancer chemo-therapy and radiotherapy.
Current medicinal chemistry. Anti-cancer agents 2002;2(6):683-90.
2002: Lynne W Elmore; Catherine W Rehder; Xu Di; Patricia McChesney; Colleen Jackson-Cook; David Gewirtz; Shawn E Holt
Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction.
The Journal of biological chemistry 2002;277(38):35509-15.
2001: KJ Magnet; MS Orr; J L Cleveland; C Rodriguez-Galindo; H Yang; C Yang; YM Di; PT Jain; David Gewirtz
Suppression of c-myc expression and c-Myc function in response to sustained DNA damage in MCF-7 breast tumor cells.
Biochemical pharmacology 2001;62(5):593-602.
2001: Gary H Posner; Kenneth R Crawford; Sara Peleg; J E Welsh; S Romu; David Gewirtz; Mona S Gupta; Patrick Dolan; Thomas W Kensler
A non-calcemic sulfone version of the vitamin D(3) analogue seocalcitol (EB 1089): chemical synthesis, biological evaluation and potency enhancement of the anticancer drug adriamycin.
Bioorganic & medicinal chemistry 2001;9(9):2365-71.
2001: M Chaudhry; Sujatha Sundaram; Chris Gennings; H Carter; David Gewirtz
The vitamin D3 analog, ILX-23-7553, enhances the response to adriamycin and irradiation in MCF-7 breast tumor cells.
Cancer chemotherapy and pharmacology 2001;47(5):429-36.
2001: David Gewirtz; YM Di; JK Randolph; PT Jain; K Valerie; S Bullock; Niharika Nath; Srikumar Chellappan
Rb dephosphorylation and suppression of E2F activity in human breast tumor cells exposed to a pharmacological concentration of estradiol.
Archives of biochemistry and biophysics 2001;388(2):243-52.
2000: David Gewirtz
Overview. A new discovery phase for antitumor drugs?
Current opinion in investigational drugs (London, England : 2000) 2000;1(4):508-10.
2000: Sujatha Sundaram; M Chaudhry; D Reardon; M Gupta; David Gewirtz
The vitamin D3 analog EB 1089 enhances the antiproliferative and apoptotic effects of adriamycin in MCF-7 breast tumor cells.
Breast cancer research and treatment 2000;63(1):1-10.
2000: David Gewirtz
Growth arrest and cell death in the breast tumor cell in response to ionizing radiation and chemotherapeutic agents which induce DNA damage.
Breast cancer research and treatment 2000;62(3):223-35.
2000: David Gewirtz; Sujatha Sundaram; KJ Magnet
Influence of topoisomerase II inhibitors and ionizing radiation on growth arrest and cell death pathways in the breast tumor cell.
Cell biochemistry and biophysics 2000;33(1):19-31.
1999: Sujatha Sundaram; David Gewirtz
The vitamin D3 analog EB 1089 enhances the response of human breast tumor cells to radiation.
Radiation research 1999;152(5):479-86.
1999: PT Jain; Prem Seth; David Gewirtz
Estradiol enhances liposome-mediated uptake, preferential nuclear accumulation and functional expression of exogenous genes in MDA-MB231 breast tumor cells.
Biochimica et biophysica acta 1999;1451(2-3):224-32.
1999: David Gewirtz
A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin.
Biochemical pharmacology 1999;57(7):727-41.
1999: PT Jain; David Gewirtz
Sustained enhancement of liposome-mediated gene delivery and gene expression in human breast tumour cells by ionizing radiation.
International journal of radiation biology 1999;75(2):217-23.
1998: PT Jain; David Gewirtz
Estradiol enhances gene delivery to human breast tumor cells.
Journal of molecular medicine (Berlin, Germany) 1998;76(10):709-14.
1998: PT Jain; FA Fornari; JK Randolph; MS Orr; David Gewirtz
Induction of DNA damage, inhibition of DNA synthesis, and suppression of c-myc expression by the topoisomerase I inhibitor, camptothecin, in MCF-7 human breast tumor cells.
Biochemical pharmacology 1998;55(8):1263-9.
1998: PT Jain; David Gewirtz
Enhancement of liposomal gene delivery in human breast cancer cells by dimethyl sulfoxide.
International journal of molecular medicine 1998;1(3):609-11.
1998: David Gewirtz; JK Randolph; J Chawla; MS Orr; FA Fornari
Induction of DNA damage, inhibition of DNA synthesis and suppression of c-myc expression by the anthracycline analog, idarubicin (4-demethoxy-daunorubicin) in the MCF-7 breast tumor cell line.
Cancer chemotherapy and pharmacology 1998;41(5):361-9.
1997: N C Watson; YM Di; MS Orr; FA Fornari; JK Randolph; KJ Magnet; PT Jain; David Gewirtz
Influence of ionizing radiation on proliferation, c-myc expression and the induction of apoptotic cell death in two breast tumour cell lines differing in p53 status.
International journal of radiation biology 1997;72(5):547-59.
1997: MS Orr; N C Watson; Sujatha Sundaram; JK Randolph; PT Jain; David Gewirtz
Ionizing radiation and teniposide increase p21(waf1/cip1) and promote Rb dephosphorylation but fail to suppress E2F activity in MCF-7 breast tumor cells.
Molecular pharmacology 1997;52(3):373-9.
1996: FA Fornari; D W Jarvis; Steven Grant; MS Orr; JK Randolph; F K White; David Gewirtz
Growth arrest and non-apoptotic cell death associated with the suppression of c-myc expression in MCF-7 breast tumor cells following acute exposure to doxorubicin.
Biochemical pharmacology 1996;51(7):931-40.
1996: N C Watson; W David Jarvis; MS Orr; Steven Grant; David Gewirtz
Radiosensitization of HL-60 human leukaemia cells by bryostatin-1 in the absence of increased DNA fragmentation or apoptotic cell death.
International journal of radiation biology 1996;69(2):183-92.
1995: R T Bunch; David Gewirtz; Lawrence F Povirk
Ionizing radiation-induced DNA strand breakage and rejoining in specific genomic regions as determined by an alkaline unwinding/Southern blotting method.
International journal of radiation biology 1995;68(5):553-62.
1995: MS Orr; FA Fornari; JK Randolph; David Gewirtz
Transcriptional down-regulation of c-myc expression in the MCF-7 breast tumor cell line by the topoisomerase II inhibitor, VM-26.
Biochimica et biophysica acta 1995;1262(2-3):139-45.
1994: W David Jarvis; FA Fornari; J L Browning; David Gewirtz; Richard Kolesnick; Steven Grant
Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia cells.
The Journal of biological chemistry 1994;269(50):31685-92.
1994: FA Fornari; W David Jarvis; Steven Grant; MS Orr; JK Randolph; F K White; V R Mumaw; E T Lovings; R H Freeman; David Gewirtz
Induction of differentiation and growth arrest associated with nascent (nonoligosomal) DNA fragmentation and reduced c-myc expression in MCF-7 human breast tumor cells after continuous exposure to a sublethal concentration of doxorubicin.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(7):723-33.
1994: K E Woods; JK Randolph; David Gewirtz
Antagonism between tamoxifen and doxorubicin in the MCF-7 human breast tumor cell line.
Biochemical pharmacology 1994;47(8):1449-52.
1994: FA Fornari; JK Randolph; Jack C Yalowich; M K Ritke; David Gewirtz
Interference by doxorubicin with DNA unwinding in MCF-7 breast tumor cells.
Molecular pharmacology 1994;45(4):649-56.
1994: W David Jarvis; Lawrence F Povirk; A J Turner; R S Traylor; David Gewirtz; George R Pettit; Steven Grant
Effects of bryostatin 1 and other pharmacological activators of protein kinase C on 1-[beta-D-arabinofuranosyl]cytosine-induced apoptosis in HL-60 human promyelocytic leukemia cells.
Biochemical pharmacology 1994;47(5):839-52.
1994: R T Bunch; Lawrence F Povirk; MS Orr; JK Randolph; FA Fornari; David Gewirtz
Influence of amsacrine (m-AMSA) on bulk and gene-specific DNA damage and c-myc expression in MCF-7 breast tumor cells.
Biochemical pharmacology 1994;47(2):317-29.
1994: W David Jarvis; Richard Kolesnick; FA Fornari; R S Traylor; David Gewirtz; Steven Grant
Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(1):73-7.
1994: K E Woods; Steven Grant; Saul Yanovich; David Gewirtz
Variable effects of tamoxifen on human hematopoietic progenitor cell growth and sensitivity to doxorubicin.
Cancer chemotherapy and pharmacology 1994;33(6):509-14.
1993: David Gewirtz; MS Orr; FA Fornari; JK Randolph; Jack C Yalowich; M K Ritke; Lawrence F Povirk; R T Bunch
Dissociation between bulk damage to DNA and the antiproliferative activity of teniposide (VM-26) in the MCF-7 breast tumor cell line: evidence for induction of gene-specific damage and alterations in gene expression.
Cancer research 1993;53(15):3547-54.
1993: David Gewirtz
DNA damage, gene expression, growth arrest and cell death.
Oncology research 1993;5(10-11):397-408.
1992: Steven Grant; W David Jarvis; Paul Steven Swerdlow; A J Turner; R S Traylor; H J Wallace; P S Lin; George R Pettit; David Gewirtz
Potentiation of the activity of 1-beta-D-arabinofuranosylcytosine by the protein kinase C activator bryostatin 1 in HL-60 cells: association with enhanced fragmentation of mature DNA.
Cancer research 1992;52(22):6270-8.
1992: R T Bunch; David Gewirtz; Lawrence F Povirk
A combined alkaline unwinding/Southern blotting assay for measuring low levels of cellular DNA breakage within specific genomic regions.
Oncology research 1992;4(1):7-15.
1991: David Gewirtz
Does bulk damage to DNA explain the cytostatic and cytotoxic effects of topoisomerase II inhibitors?
Biochemical pharmacology 1991;42(12):2253-8.
1990: A L Ellis; JK Randolph; B R Conway; David Gewirtz
Biochemical lesions in DNA associated with the antiproliferative effects of mitoxantrone in the hepatoma cell.
Biochemical pharmacology 1990;39(10):1549-56.
1990: W F Kuhn; Douglas M Heuman; Z Reno Vlahcevic; David Gewirtz
Receptor-mediated stimulation of taurocholate efflux from the rat hepatocyte and the ex vivo perfused rat liver.
European journal of pharmacology 1990;175(2):117-28.
1989: K E Woods; A L Ellis; JK Randolph; David Gewirtz
Enhanced sensitivity of the rat hepatoma cell to the daunorubicin analogue 4-demethoxydaunorubicin associated with induction of DNA damage.
Cancer research 1989;49(17):4846-51.
1989: Saul Yanovich; R E Hall; David Gewirtz
Characterization of a K562 multidrug-resistant cell line.
Cancer research 1989;49(16):4499-503.
1989: David Gewirtz; A L Ellis; JK Randolph; Saul Yanovich; Paul Steven Swerdlow; Lawrence F Povirk; Jack C Yalowich
Expression of protein-associated DNA damage in the alkaline elution assay in the absence of enzymatic deproteinization.
Cancer communications 1989;1(3):175-80.
1988: W F Kuhn; David Gewirtz
Stimulation of taurocholate and glycocholate efflux from the rat hepatocyte by arginine vasopressin.
The American journal of physiology 1988;254(5 Pt 1):G732-40.
1988: C Munger; A Ellis; K Woods; J Randolph; Saul Yanovich; David Gewirtz
Evidence for inhibition of growth related to compromised DNA synthesis in the interaction of daunorubicin with H-35 rat hepatoma.
Cancer research 1988;48(9):2404-11.
1987: David Gewirtz; Saul Yanovich
Metabolism of adriamycin in hepatocytes isolated from the rat and the rabbit.
Biochemical pharmacology 1987;36(11):1793-8.
1986: David Gewirtz; Saul Yanovich
Metabolism of the anthracycline antibiotic daunorubicin to daunorubicinol and deoxydaunorubicinol aglycone in hepatocytes isolated from the rat and the rabbit.
Biochemical pharmacology 1986;35(22):4059-64.
1985: David Gewirtz; JK Randolph; M Jaramillo
Induction of methotrexate release from rat hepatocytes in suspension by alpha-adrenergic agents: involvement of calcium and metabolic energy.
Archives of biochemistry and biophysics 1985;237(1):237-43.
1984: David Gewirtz; J H Plotkin; JK Randolph
Interaction of probenecid with methotrexate transport and release in the isolated rat hepatocyte in suspension.
Cancer research 1984;44(9):3846-50.
1984: David Gewirtz; JK Randolph; I David Goldman
Induction of taurocholate release from isolated rat hepatocytes in suspension by alpha-adrenergic agents and vasopressin: implications for control of bile salt secretion.
Hepatology (Baltimore, Md.) 1984;4(2):205-12.
1983: D W Fry; David Gewirtz; Jack C Yalowich; I David Goldman
Characteristics of the accumulation of methotrexate polyglutamate derivatives in Ehrlich ascites tumor cells and isolated rat hepatocytes.
Advances in experimental medicine and biology 1983;163():215-34.
1982: David Gewirtz; JK Randolph; I David Goldman
Catecholamine-induced release of the folic acid analogue, methotrexate, from rat hepatocytes in suspension. An alpha-adrenergic phenomenon.
Molecular pharmacology 1982;22(2):493-9.
1981: David Gewirtz; JK Randolph; I David Goldman
Efflux in isolated hepatocytes as a possible correlate of secretion in vivo: induced exit of the folic acid analog methotrexate, by dibutyryl cyclic AMP or isobutyl methyl xanthine.
Biochemical and biophysical research communications 1981;101(2):366-74.
1980: David Gewirtz; JK Randolph; I David Goldman
Potent bile salt and organic anion inhibition of methotrexate uptake and accumulation in the freshly isolated rat hepatocyte.
Cancer research 1980;40(6):1852-7.
1980: David Gewirtz; J C White; JK Randolph; I David Goldman
Transport, binding, and polyglutamation of methotrexate in freshly isolated rat hepatocytes.
Cancer research 1980;40(3):573-8.