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Martin Merkel

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Alexander Bartelt; Martin Merkel; Joerg Heeren
A new, powerful player in lipoprotein metabolism: brown adipose tissue.
Stefan K Nilsson; Gunilla Olivecrona; Joerg Heeren; Martin Merkel
Apolipoprotein A-V; a potent triglyceride reducer.
May Brundert; Joerg Heeren; Martin Merkel; Antonella Carambia; Johannes Herkel; Peter Groitl; Thomas Dobner; Rajasekhar Ramakrishnan; Kathryn J Moore; Franz Rinninger
Scavenger receptor CD36 mediates uptake of high density lipoproteins in mice and by cultured cells.

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All Publications

2012: Alexander Bartelt; Martin Merkel; Joerg Heeren
A new, powerful player in lipoprotein metabolism: brown adipose tissue.
Journal of molecular medicine (Berlin, Germany) 2012;90(8):887-93.
2011: Stefan K Nilsson; Gunilla Olivecrona; Joerg Heeren; Martin Merkel
Apolipoprotein A-V; a potent triglyceride reducer.
Atherosclerosis 2011;219(1):15-21.
2011: May Brundert; Joerg Heeren; Martin Merkel; Antonella Carambia; Johannes Herkel; Peter Groitl; Thomas Dobner; Rajasekhar Ramakrishnan; Kathryn J Moore; Franz Rinninger
Scavenger receptor CD36 mediates uptake of high density lipoproteins in mice and by cultured cells.
Journal of lipid research 2011;52(4):745-58.
2011: Martin Merkel; J Heeren
[Energy, brown adipose tissue, obesity].
Deutsche medizinische Wochenschrift (1946) 2011;136(11):548-50.
2011: Alexander Bartelt; Oliver T Bruns; Rudolph Reimer; Heinz Hohenberg; Harald Ittrich; Kersten Peldschus; Michael G Kaul; Ulrich I Tromsdorf; Horst Weller; Christian Waurisch; Alexander Eychmüller; Philip L S M Gordts; Franz Rinninger; Karoline Bruegelmann; Barbara Freund; Peter Nielsen; Martin Merkel; Joerg Heeren
Brown adipose tissue activity controls triglyceride clearance.
Nature medicine 2011;17(2):200-5.
2010: Joerg Heeren; Martin Merkel
Hypertriglyceridemia in obese subjects: caused by reduced apolipoprotein A5 plasma levels?
Atherosclerosis 2010;212(2):386-7.
2010: Dirk Müller-Wieland; Birgit Knebel; Jutta Haas; Martin Merkel; Jörg Kotzka
[Obesity: ectopic fat distribution and the heart].
Herz 2010;35(3):198-205.
2009: B Kohlschütter; Martin Merkel; René Santer; Mikhail Tchirikov; M Ellerbrok; J Zschocke; Kurt Ullrich
Phenylalanine tolerance in three phenylketonuric women pregnant with fetuses of different genetic PKU status.
Journal of inherited metabolic disease 2009;32 Suppl 1():S1-4.
2009: Martin Merkel
[Diabetic dyslipoproteinemia: beyond LDL].
Deutsche medizinische Wochenschrift (1946) 2009;134(20):1067-73.
2009: Martin Merkel
[53-year-old man with "lipemic" plasma and conspicuous skin eruptions].
Deutsche medizinische Wochenschrift (1946) 2009;134(20):1053-4.
2009: Alexander Laatsch; Martin Merkel; Philippa J Talmud; Thomas Grewal; Ulrike Beisiegel; Joerg Heeren
Insulin stimulates hepatic low density lipoprotein receptor-related protein 1 (LRP1) to increase postprandial lipoprotein clearance.
Atherosclerosis 2009;204(1):105-11.
2009: Oliver T Bruns; Harald Ittrich; Kersten Peldschus; Michael G Kaul; Ulrich I Tromsdorf; Joachim Lauterwasser; Marija S Nikolic; Birgit Mollwitz; Martin Merkel; Nadja C Bigall; Sameer Sapra; Rudolph Reimer; Heinz Hohenberg; Horst Weller; Alexander Eychmüller; Gerhard Adam; Ulrike Beisiegel; Joerg Heeren
Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals.
Nature nanotechnology 2009;4(3):193-201.
2008: B Dorfmeister; W W Zeng; A Dichlberger; S K Nilsson; F G Schaap; J A Hubacek; Martin Merkel; Jackie A Cooper; A Lookene; Wendy Putt; R Whittall; P J Lee; laurence lins; N Delsaux; M Nierman; J A Kuivenhoven; J J P Kastelein; M Vrablik; Gunilla Olivecrona; W J Schneider; J Heeren; Steve E Humphries; Philippa J Talmud
Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(10):1866-71.
2008: Andreas Niemeier; Dagmara Niedzielska; Rukiye Secer; Arndt Schilling; Martin Merkel; Carlos Enrich; Patrick C N Rensen; Joerg Heeren
Uptake of postprandial lipoproteins into bone in vivo: impact on osteoblast function.
Bone 2008;43(2):230-7.
2008: Daniëlle H J Martens; Jan Peter Rake; Martin Schwarz; Kurt Ullrich; David A Weinstein; Martin Merkel; Pieter J J Sauer; G Peter A Smit
Pregnancies in glycogen storage disease type Ia.
American journal of obstetrics and gynecology 2008;198(6):646.e1-7.
2008: Wanda Velez-Carrasco; Martin Merkel; Christian O Twiss; Jonathan D. Smith
Dietary methionine effects on plasma homocysteine and HDL metabolism in mice.
The Journal of nutritional biochemistry 2008;19(6):362-70.
2008: M Kluger; Joerg Heeren; Martin Merkel
Apoprotein A-V: an important regulator of triglyceride metabolism.
Journal of inherited metabolic disease 2008;31(2):281-8.
2007: Britta Loeffler; Joerg Heeren; Mareike Blaeser; Herbert Radner; Daniel Kayser; Birol Aydin; Martin Merkel
Lipoprotein lipase-facilitated uptake of LDL is mediated by the LDL receptor.
Journal of lipid research 2007;48(2):288-98.
2006: Roshni R Singaraja; Bjorn Stahmer; May Brundert; Martin Merkel; Joerg Heeren; Nagat Bissada; Martin Kang; Jenelle M Timmins; Rajasekhar Ramakrishnan; John S Parks; Michael R Hayden; Franz Rinninger
Hepatic ATP-binding cassette transporter A1 is a key molecule in high-density lipoprotein cholesteryl ester metabolism in mice.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(8):1821-7.
2005: Martin Merkel; Joerg Heeren
Give me A5 for lipoprotein hydrolysis!
The Journal of clinical investigation 2005;115(10):2694-6.
2005: Sergei Ragozin; Andreas Niemeier; Alexander Laatsch; Britta Loeffler; Martin Merkel; Ulrike Beisiegel; Joerg Heeren
Knockdown of hepatic ABCA1 by RNA interference decreases plasma HDL cholesterol levels and influences postprandial lipemia in mice.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(7):1433-8.
2005: Martin Merkel; Britta Loeffler; Malte Kluger; Nathalie Fabig; Gesa Geppert; Len A Pennacchio; Alexander Laatsch; Joerg Heeren
Apolipoprotein AV accelerates plasma hydrolysis of triglyceride-rich lipoproteins by interaction with proteoglycan-bound lipoprotein lipase.
The Journal of biological chemistry 2005;280(22):21553-60.
2005: Chris Mühlhausen; Reinhard Schneppenheim; U Budde; Martin Merkel; Nicole Muschol; Kurt Ullrich; R Santer
Decreased plasma concentration of von Willebrand factor antigen (VWF:Ag) in patients with glycogen storage disease type Ia.
Journal of inherited metabolic disease 2005;28(6):945-50.
2005: May Brundert; Anne Ewert; Joerg Heeren; Barbara Behrendt; Rajasekhar Ramakrishnan; Heiner Greten; Martin Merkel; Franz Rinninger
Scavenger receptor class B type I mediates the selective uptake of high-density lipoprotein-associated cholesteryl ester by the liver in mice.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(1):143-8.
2004: E Peer Lutz; Yuko Kako; Hiroaki Yagyu; Joerg Heeren; Steven Marks; Thamrah Wright; Kristan Melford; Osnat Ben-Zeev; Herbert Radner; Martin Merkel; André Bensadoun; Howard Wong; Ira J Goldberg
Mice expressing only covalent dimeric heparin binding-deficient lipoprotein lipase: muscles inefficiently secrete dimeric enzyme.
The Journal of biological chemistry 2004;279(1):238-44.
2003: Martin Merkel; Herbert Radner; Heiner Greten
[Lipoprotein lipase-mediated myopathy: implications for lipid metabolism and atherogenesis].
Medizinische Klinik (Munich, Germany : 1983) 2003;98(12):679-84.
2003: Martin Merkel; Heiner Greten
[L-carnitine and lipid lowering].
Deutsche medizinische Wochenschrift (1946) 2003;128(34-35):1792.
2003: Stefan Kluge; Peter Kühnelt; Andreas Block; Martin Merkel; Andreas Gocht; Zoltan Lukacs; Alfried Kohlschuetter; Georg Kreymann
A young woman with persistent hypoglycemia, rhabdomyolysis, and coma: recognizing fatty acid oxidation defects in adults.
Critical care medicine 2003;31(4):1273-6.
2003: Hiroaki Yagyu; Guangping Chen; Masayoshi Yokoyama; Kumiko Hirata; Ayanna Augustus; Yuko Kako; Toru Seo; Yunying Hu; E Peer Lutz; Martin Merkel; André Bensadoun; Shunichi Homma; Ira J Goldberg
Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy.
The Journal of clinical investigation 2003;111(3):419-26.
2002: Martin Merkel; Robert H Eckel; Ira J Goldberg
Lipoprotein lipase: genetics, lipid uptake, and regulation.
Journal of lipid research 2002;43(12):1997-2006.
2002: Joerg Heeren; Andreas Niemeier; Martin Merkel; Ulrike Beisiegel
Endothelial-derived lipoprotein lipase is bound to postprandial triglyceride-rich lipoproteins and mediates their hepatic clearance in vivo.
Journal of molecular medicine (Berlin, Germany) 2002;80(9):576-84.
2002: Martin Merkel; Joerg Heeren; Wiebke Dudeck; Franz Rinninger; Herbert Radner; Jan L Breslow; Ira J Goldberg; Rudolf Zechner; Heiner Greten
Inactive lipoprotein lipase (LPL) alone increases selective cholesterol ester uptake in vivo, whereas in the presence of active LPL it also increases triglyceride hydrolysis and whole particle lipoprotein uptake.
The Journal of biological chemistry 2002;277(9):7405-11.
2001: Martin Merkel; W Velez-Carrasco; Lisa Cooper Hudgins; Jan L Breslow
Compared with saturated fatty acids, dietary monounsaturated fatty acids and carbohydrates increase atherosclerosis and VLDL cholesterol levels in LDL receptor-deficient, but not apolipoprotein E-deficient, mice.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):13294-9.
2001: E Peer Lutz; Martin Merkel; Yuko Kako; Kristan Melford; Herbert Radner; Jan L Breslow; André Bensadoun; Ira J Goldberg
Heparin-binding defective lipoprotein lipase is unstable and causes abnormalities in lipid delivery to tissues.
The Journal of clinical investigation 2001;107(9):1183-92.
2001: Ira J Goldberg; Martin Merkel
Lipoprotein lipase: physiology, biochemistry, and molecular biology.
Frontiers in bioscience : a journal and virtual library 2001;6():D388-405.
2000: Ephraim Sehayek; Sarah Shefer; Lien B Nguyen; Jennie G Ono; Martin Merkel; Jan L Breslow
Apolipoprotein E regulates dietary cholesterol absorption and biliary cholesterol excretion: studies in C57BL/6 apolipoprotein E knockout mice.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3433-7.
1999: ER De Oliveira e Silva; M Kong; Zhihua Han; Catherine J Starr; E M Kass; S H Juo; D Foster; Hayes M Dansky; Martin Merkel; K Cundey; E A Brinton; Jan L Breslow; Jonathan D. Smith
Metabolic and genetic determinants of HDL metabolism and hepatic lipase activity in normolipidemic females.
Journal of lipid research 1999;40(7):1211-21.
1999: A C Tilkorn; Martin Merkel; Heiner Greten; D Meis
High-level baculoviral expression of lysosomal acid lipase.
Methods in molecular biology (Clifton, N.J.) 1999;109():177-85.
1999: Martin Merkel; A C Tilkorn; Heiner Greten; Detlev Ameis
Lysosomal acid lipase. Assay and purification.
Methods in molecular biology (Clifton, N.J.) 1999;109():95-107.
1998: Martin Merkel; Yuko Kako; Herbert Radner; I S Cho; R Ramasamy; J D Brunzell; Ira J Goldberg; Jan L Breslow
Catalytically inactive lipoprotein lipase expression in muscle of transgenic mice increases very low density lipoprotein uptake: direct evidence that lipoprotein lipase bridging occurs in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13841-6.
1998: Martin Merkel; PH Weinstock; T Chajek-Shaul; Herbert Radner; B Yin; Jan L Breslow; Ira J Goldberg
Lipoprotein lipase expression exclusively in liver. A mouse model for metabolism in the neonatal period and during cachexia.
The Journal of clinical investigation 1998;102(5):893-901.
1997: PH Weinstock; Charles L Bisgaier; T Hayek; K Aalto-Setala; Ephraim Sehayek; L Wu; P Sheiffele; Martin Merkel; AD Essenburg; Jan L Breslow
Decreased HDL cholesterol levels but normal lipid absorption, growth, and feeding behavior in apolipoprotein A-IV knockout mice.
Journal of lipid research 1997;38(9):1782-94.
1995: D Ameis; G Brockmann; R Knoblich; Martin Merkel; Richard E Ostlund; J W Yang; P M Coates; JA Cortner; S V Feinman; Heiner Greten
A 5' splice-region mutation and a dinucleotide deletion in the lysosomal acid lipase gene in two patients with cholesteryl ester storage disease.
Journal of lipid research 1995;36(2):241-50.
1994: D Ameis; Martin Merkel; C Eckerskorn; Heiner Greten
Purification, characterization and molecular cloning of human hepatic lysosomal acid lipase.
European journal of biochemistry / FEBS 1994;219(3):905-14.