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Stephen Brennan

Research Profile

Genes & Molecular Sequences

Amino Acid Sequences

Chemicals & Drugs

Physiology

Disorders

Afibrinogenemia

Concepts & Ideas

Living Beings

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Publications

TOP 3
Stephen O Brennan; Maurice C Owen; Beverley Pullon; Thomas Brittain
Novel haemoglobin mutation (α127Lys→Glu) increases oxygen affinity and has a minor effect on haptoglobin binding.
Richard D Ireland; Stephen O Brennan; Peter M George; Juliet A Gerrard; Trevor A Walmsley; Richard I King
A mass-spectroscopic method for measuring des-Leu albumin--a novel marker for chronic pancreatitis.
Stephen O Brennan; Richard I King; Christopher M Florkowski
β37Trp→Cys mutation leads to multiple new hemoglobin species in red cells.

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All Publications

2012: Stephen O Brennan; Maurice C Owen; Beverley Pullon; Thomas Brittain
Novel haemoglobin mutation (α127Lys→Glu) increases oxygen affinity and has a minor effect on haptoglobin binding.
Clinical biochemistry 2012;45(18):1587-90.
2012: Richard D Ireland; Stephen O Brennan; Peter M George; Juliet A Gerrard; Trevor A Walmsley; Richard I King
A mass-spectroscopic method for measuring des-Leu albumin--a novel marker for chronic pancreatitis.
Clinical biochemistry 2012;45(18):1664-8.
2012: Stephen O Brennan; Richard I King; Christopher M Florkowski
β37Trp→Cys mutation leads to multiple new hemoglobin species in red cells.
Clinical biochemistry 2012;45(3):259-63.
2011: Stephen O Brennan; Fernando Roncolato
Novel fibrinogen (B β401Gly→Val) presents as dys- or hypodysfibrinogenaemia due to alterations in sialic acid content.
Thrombosis and haemostasis 2011;106(3):551-3.
2011: Stephen O Brennan; J Oliver; R L Davis
Epigenetic, polymorphic and mutational (Αα167Arg→Lys) contribution to a functionally abnormal fibrinogen.
Journal of thrombosis and haemostasis : JTH 2011;9(7):1410-2.
2011: Stephen O Brennan; Jocelyn Oliver; Ryan L Davis
Adjacent substitutions (γ352Gly→Cys and 353Thr→Pro) in fibrinogen Ilam cause diminished γ chain expression.
Thrombosis and haemostasis 2011;105(2):379-81.
2010: Stephen O Brennan; Ryan L Davis; Robin Lowen; Bart Baker
Benign substitution (Aα289 Arg→Gln) in the αC region of human fibrinogen.
Blood cells, molecules & diseases 2010;45(4):336-7.
2010: Stephen O Brennan; Ryan L Davis
Substitution (γ335Trp→Arg) in fibrinogen Fremantle causes diminished γ chain expression and increased sialic acid content.
Thrombosis and haemostasis 2010;104(6):1274-6.
2010: Stephen O Brennan; Ryan L Davis; Katrina Conard; Anthony Savo; Katryn N Furuya
Novel fibrinogen mutation γ314Thr→Pro (fibrinogen AI duPont) associated with hepatic fibrinogen storage disease and hypofibrinogenaemia.
Liver international : official journal of the International Association for the Study of the Liver 2010;30(10):1541-7.
2010: Campbell R Sheen; Amy Dear; Stephen O Brennan
Expression of four mutant fibrinogen gammaC domains in Pichia pastoris confirms them as causes of hypofibrinogenaemia.
Protein expression and purification 2010;73(2):184-8.
2010: Stephen O Brennan; R L Davis; M Chitlur
New fibrinogen substitution (gammaSer313Arg) causes diminished gamma chain expression and hypodysfibrinogenaemia.
Thrombosis and haemostasis 2010;103(2):478-9.
2010: Stephen O Brennan; Sheila Ryken; Tim Chan
Hb Koya Dora [alpha142, Term-->Ser (TAA>TCA in alpha2)]: a rare mutation of the alpha2 gene stop codon associated with alpha-thalassemia.
Hemoglobin 2010;34(4):402-5.
2010: Stephen O Brennan; Tim Chan
Hb Perpignan [beta136(H14)Gly-->Ser], a silent variant associated with normal hematology.
Hemoglobin 2010;34(2):157-60.
2009: Carl-Erik Dempfle; Peter M George; Martin Borggrefe; Michael Neumaier; Stephen O Brennan
Demonstration of heterodimeric fibrinogen molecules partially conjugated with albumin in a novel dysfibrinogen: fibrinogen Mannheim V.
Thrombosis and haemostasis 2009;102(1):29-34.
2009: Ryan L Davis; Stephen May; Sanjeev Chunilal; Stephen O Brennan
Two novel mutations at contiguous codons in the fibrinogen Bbeta chain associated with hypofibrinogenaemia.
Thrombosis and haemostasis 2009;101(5):980-2.
2009: Stephen O Brennan; Ryan L Davis; Robin Lowen; Anna Ruskova
Deletion of five residues from the coiled coil of fibrinogen (Bbeta Asn167_Glu171del) associated with bleeding and hypodysfibrinogenemia.
Haematologica 2009;94(4):585-8.
2009: Ryan L Davis; Vivienne M Homer; Peter M George; Stephen O Brennan
A deep intronic mutation in FGB creates a consensus exonic splicing enhancer motif that results in afibrinogenemia caused by aberrant mRNA splicing, which can be corrected in vitro with antisense oligonucleotide treatment.
Human mutation 2009;30(2):221-7.
2009: Stephen O Brennan; Tim Chan; Sheila Ryken; Anna Ruskova
A second case of Hb Fontainebleau [alpha21(B2)Ala-->Pro] in an individual with microcytosis.
Hemoglobin 2009;33(3):258-61.
2008: Ryan L Davis; Theodore Peters; Stephen O Brennan
Novel frameshift in the serum albumin gene results in analbuminemia through premature truncation and post translational modification.
Clinical biochemistry 2008;41(18):1482-5.
2008: Ryan L Davis; Bartrum Baker; Stephen O Brennan
Fibrinogen Foxton: a novel BbetaA277V mutation causing low normal plasma fibrinogen concentration.
Thrombosis and haemostasis 2008;100(4):708-10.
2008: Stephen O Brennan; Maurice C Owen; Tim Chan; Anna Ruskova
Novel hemoglobin alpha chain elongation resulting from a 15-residue insertion and tandem duplication of the F helix.
Clinical biochemistry 2008;41(14-15):1156-61.
2008: Stephen O Brennan
Fifty-eight years of hemoglobin analysis.
Clinical chemistry 2008;54(1):8-10.
2007: David Schmidt; Stephen O Brennan
Modified form of the fibrinogen Bbeta chain (des-Gln Bbeta), a potential long-lived marker of pancreatitis.
Clinical chemistry 2007;53(12):2105-11.
2007: Campbell R Sheen; Ursula R Jewell; Christine Morris; Stephen O Brennan; Claude Férec; Peter M George; Mark P Smith; Jian-Min Chen
Double complex mutations involving F8 and FUNDC2 caused by distinct break-induced replication.
Human mutation 2007;28(12):1198-206.
2007: Amy Dear; Stephen O Brennan; M J Sheat; JM Faed; Peter M George
Acquired dysfibrinogenemia caused by monoclonal production of immunoglobulin lambda light chain.
Haematologica 2007;92(11):e111-7.
2007: Ryan L Davis; Stephen O Brennan
Fibrinogen Tolaga Bay: a novel gammaAla341Val mutation causing hypofibrinogenaemia.
Thrombosis and haemostasis 2007;98(5):1136-8.
2007: Michael Meyer; Hermann Dietzel; Ralph Kaetzel; David Schmidt; Karin Liebscher; Stephen O Brennan
Fibrinogen Leipzig II (gamma351Gly-->Ser and gamma82Ala-->Gly): hypodysfibrinogenaemia due to two independent amino acid substitutions within the same polypeptide chain.
Thrombosis and haemostasis 2007;98(4):903-5.
2007: Stephen O Brennan; Tim Chan; Michael Beard
Hemoglobin Hagley Park: a novel (alpha82Ala-->Thr) substitution identified in an infant with severe hemolytic anemia.
Clinical chemistry 2007;53(9):1718-9.
2007: Stephen O Brennan; Ryan L Davis; Michael W Mosesson; Irene Hernandez; Robin Lowen; Saramma J Alexander
Congenital hypodysfibrinogenaemia (Fibrinogen Des Moines) due to a gamma320Asp deletion at the Ca2+ binding site.
Thrombosis and haemostasis 2007;98(2):467-9.
2007: Ryan L Davis; Michael W Mosesson; Bryce A Kerlin; Jason A Canner; Frederick B Ruymann; Stephen O Brennan
Fibrinogen Columbus: a novel gamma Gly200Val mutation causing hypofibrinogenemia in a family with associated thrombophilia.
Haematologica 2007;92(8):1151-2.
2007: Adam G Testro; Stephen O Brennan; Richard A L Macdonell; Philip N Hawkins; Peter W Angus
Hereditary amyloidosis with progressive peripheral neuropathy associated with apolipoprotein AI Gly26Arg: outcome of hepatorenal transplantation.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2007;13(7):1028-31.
2007: Victoria J Metcalf; Peter M George; Stephen O Brennan
Lungfish albumin is more similar to tetrapod than to teleost albumins: purification and characterisation of albumin from the Australian lungfish, Neoceratodus forsteri.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2007;147(3):428-37.
2007: Stephen O Brennan; Tim Chan; Campbell R Sheen
Novel hemoglobin (Hb Grey Lynn) substitution (alpha91Leu --> Phe) affects heme interactions and alpha1beta2 contacts.
Clinical chemistry 2007;53(5):990-1.
2007: Glenys A Tennent; Stephen O Brennan; Arie J Stangou; John O'Grady; Philip N Hawkins; Mark B Pepys
Human plasma fibrinogen is synthesized in the liver.
Blood 2007;109(5):1971-4.
2007: Oi Wah Liew; Pek Ching Jenny Chong; Yok Zuan Lim; Cui Xia Ang; Yong Chen Amy Lau; Timothy G Yandle; Stephen O Brennan
An SRLLR motif downstream of the scissile bond enhances enterokinase cleavage efficiency.
Biochimie 2007;89(1):21-9.
2006: Campbell R Sheen; Joyce Low; Joanne Joseph; Eugene Kotlyar; Peter M George; Stephen O Brennan
Fibrinogen Darlinghurst: hypofibrinogenaemia caused by a W253G mutation in the gamma chain in a patient with both bleeding and thrombotic complications.
Thrombosis and haemostasis 2006;96(5):685-7.
2006: Stephen O Brennan; Vivienne M Homer; Ryan L Davis; Michael Meyer; Peter M George
Hypofibrinogenaemia associated with common gamma82Ala-->Gly mutation is not mediated by altered mRNA splicing.
Thrombosis and haemostasis 2006;96(4):535-7.
2006: Marian B Hill; Stephen O Brennan; Amy Dear; Jane Strong; Tara Nejim; Gerrard Dolan
Fibrinogen Nottingham II: a novel Bbeta Arg264gly substitution causing hypofibrinogenaemia.
Thrombosis and haemostasis 2006;96(3):378-80.
2006: Campbell R Sheen; Stephen O Brennan; Nada Jabado; Peter M George
Fibrinogen Montreal: a novel missense mutation (Aa D496N) associated with hypofibrinogenaemia.
Thrombosis and haemostasis 2006;96(2):231-2.
2006: Stephen O Brennan; Michael W Mosesson; Robin Lowen; Christopher Frantz
Dysfibrinogenemia (fibrinogen Wilmington) due to a novel Aalpha chain truncation causing decreased plasma expression and impaired fibrin polymerisation.
Thrombosis and haemostasis 2006;96(1):88-9.
2006: Stephen O Brennan; Michael W Mosesson; Robin Lowen; Kevin R Siebenlist; Alison Matsunaga
Hypofibrinogenaemia resulting from novel single nucleotide deletion at codon Bbeta58 (3404del A) associated with thrombotic stroke in infancy.
Thrombosis and haemostasis 2006;95(4):738-9.
2006: Kristina B Kruse; Amy Dear; Erin R Kaltenbrun; Brandan E Crum; Peter M George; Stephen O Brennan; Ardythe A McCracken
Mutant fibrinogen cleared from the endoplasmic reticulum via endoplasmic reticulum-associated protein degradation and autophagy: an explanation for liver disease.
The American journal of pathology 2006;168(4):1299-308; quiz 1404-5.
2006: Amy Dear; J Daly; Stephen O Brennan; A Tuckfield; Peter M George
An intronic mutation within FGB (IVS1+2076 a-->g) is associated with afibrinogenemia and recurrent transient ischemic attacks.
Journal of thrombosis and haemostasis : JTH 2006;4(2):471-2.
2006: Michael Meyer; Frauke Bergmann; Stephen O Brennan
Novel fibrinogen mutation (gamma 313 Ser-->Asn) associated with hypofibrinogenemia in two unrelated families.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2006;17(1):63-7.
2005: Emmanuelle de Raucourt; Philippe de Mazancourt; Ghassan J Maghzal; Stephen O Brennan; Michael W Mosesson
Fibrinogen Saint-Germain II: hypofibrinogenemia due to heterozygous gamma N345S mutation.
Thrombosis and haemostasis 2005;94(5):965-8.
2005: Stephen O Brennan; Campbell R Sheen; Peter M George
Novel gamma230 Asn-->Asp substitution in fibrinogen Middlemore associated hypofibrinogenaemia.
Thrombosis and haemostasis 2005;93(6):1196-7.
2005: Oi Wah Liew; Jenny Pek Ching Chong; Timothy G Yandle; Stephen O Brennan
Preparation of recombinant thioredoxin fused N-terminal proCNP: Analysis of enterokinase cleavage products reveals new enterokinase cleavage sites.
Protein expression and purification 2005;41(2):332-40.
2005: Amy Dear; Stephen O Brennan; Peter M George
Familial hypodysfibrinogenaemia associated with second occurrence of gamma326 Cys-->Tyr mutation.
Thrombosis and haemostasis 2005;93(3):612-3.
2005: Stephen O Brennan; Campbell R Sheen; Tim Chan; Peter M George
Hb taradale [beta82(EF6)Lys-->Arg]: a novel mutation at a 2,3-diphosphoglycerate binding site.
Hemoglobin 2005;29(4):281-4.
2005: Stephen O Brennan; Tim Chan; Mary Obele; Peter M George
Hb riccarton [alpha51(CE9)Gly-->Ser]: a variant arising from a novel mutation in the alpha1 gene.
Hemoglobin 2005;29(1):61-4.
2005: Ghassan J Maghzal; Stephen O Brennan; Peter M George
The sialic acid content of fibrinogen decreases during pregnancy and increases in response to fibrate therapy.
Thrombosis research 2005;115(4):293-9.
2004: Amy Dear; Carl-Erik Dempfle; Stephen O Brennan; W Kirschstein; Peter M George
Fibrinogen Mannheim II: a novel gamma307 His-->Tyr substitution in the gammaD domain causes hypofibrinogenemia.
Journal of thrombosis and haemostasis : JTH 2004;2(12):2194-9.
2004: Alec Mushunje; G Evans; Stephen O Brennan; Robin W Carrell; Aiwu Zhou
Latent antithrombin and its detection, formation and turnover in the circulation.
Journal of thrombosis and haemostasis : JTH 2004;2(12):2170-7.
2004: Amy Dear; Stephen O Brennan; Carl-Erik Dempfle; Werner Kirschstein; Peter M George
Hypofibrinogenaemia associated with a novel heterozygous gamma289 Ala -->Val substitution (fibrinogen Dorfen).
Thrombosis and haemostasis 2004;92(6):1291-5.
2004: Ghassan J Maghzal; Stephen O Brennan; Vivienne M Homer; Peter M George
The molecular mechanisms of congenital hypofibrinogenaemia.
Cellular and molecular life sciences : CMLS 2004;61(12):1427-38.
2004: Phil Lefebvre; Pauline T Velasco; Amy Dear; Karim C Lounes; Susan T Lord; Stephen O Brennan; David Green; Laszlo Lorand
Severe hypodysfibrinogenemia in compound heterozygotes of the fibrinogen AalphaIVS4 + 1G>T mutation and an AalphaGln328 truncation (fibrinogen Keokuk).
Blood 2004;103(7):2571-6.
2003: Ghassan J Maghzal; Stephen O Brennan; Peter M George
Fibrinogen B beta polymorphisms do not directly contribute to an altered in vitro clot structure in humans.
Thrombosis and haemostasis 2003;90(6):1021-8.
2003: Anna L P Chapman; Christine C Winterbourn; Stephen O Brennan; T William Jordan; Anthony J Kettle
Characterization of non-covalent oligomers of proteins treated with hypochlorous acid.
The Biochemical journal 2003;375(Pt 1):33-40.
2003: Stephen O Brennan; Tim Chan; Campbell R Sheen; Lisa Rae
Hb Lusaka [alpha131(H14)Ser-->phe (alpha1)]: a new variant found in a woman heterozygous for Hb S [beta6(A3)G1u-->Val].
Hemoglobin 2003;27(3):177-80.
2003: Vivienne M Homer; J L Mullin; Stephen O Brennan; A Barr; Peter M George
Novel Aalpha chain truncation (fibrinogen Perth) resulting in low expression and impaired fibrinogen polymerization.
Journal of thrombosis and haemostasis : JTH 2003;1(6):1245-50.
2003: Christopher M Florkowski; Trevor Walmsley; Stephen O Brennan; Peter M George
Haemoglobin Marseille-Long Island and interpretation of HbA1c: which HbA1c result is the "right answer"?
Postgraduate medical journal 2003;79(929):174-5.
2003: Ghassan J Maghzal; Stephen O Brennan; Andrew P Fellowes; Ruth Spearing; Peter M George
Familial hypofibrinogenaemia associated with heterozygous substitution of a conserved arginine residue; Bbeta255 Arg-->His (Fibrinogen Merivale).
Biochimica et biophysica acta 2003;1645(2):146-51.
2002: Vivienne M Homer; Stephen O Brennan; Peter M George
Novel fibrinogen Bbeta gene mutation causing hypofibrinogenaemia.
Thrombosis and haemostasis 2002;88(6):1066-7.
2002: Stephen O Brennan; Campbell R Sheen; Stephen Johnson
Hb Manawatu [alpha 37(C2)Pro-->Leu]: a new mildly unstable mutation at an invariant proline residue.
Hemoglobin 2002;26(4):389-92.
2002: Stephen O Brennan; Vivienne M Homer; Paul Ockelford; Peter M George
Low expression of truncated Aalpha chain variant in circulating fibrinogen.
Thrombosis and haemostasis 2002;88(3):533-4.
2002: Vivienne M Homer; Stephen O Brennan; Paul Ockelford; Peter M George
Novel fibrinogen truncation with deletion of Bbeta chain residues 440-461 causes hypofibrinogenaemia.
Thrombosis and haemostasis 2002;88(3):427-31.
2002: Stephen O Brennan; Ghassan J Maghzal; Benjamin L Shneider; Ronald Gordon; Margret S Magid; Peter M George
Novel fibrinogen gamma375 Arg-->Trp mutation (fibrinogen aguadilla) causes hepatic endoplasmic reticulum storage and hypofibrinogenemia.
Hepatology (Baltimore, Md.) 2002;36(3):652-8.
2002: Jennifer L Mullin; Stephen O Brennan; Peter S Ganly; Peter M George
Fibrinogen Hillsborough: a novel gammaGly309Asp dysfibrinogen with impaired clotting.
Blood 2002;99(10):3597-601.
2002: Stephen O Brennan; Howard C Potter; Lia M Kubala; Susan A Carnoutsos; Martin M Ferguson
Hb Canterbury [beta112(G14)Cys-->Phe]: a new, mildly unstable variant.
Hemoglobin 2002;26(1):67-9.
2002: Vivienne M Homer; Stephen O Brennan; Peter M George
Four novel polymorphisms in the fibrinogen Aalpha gene.
Thrombosis and haemostasis 2002;87(2):354-5.
2001: Stephen O Brennan; JM Wyatt; Andrew P Fellowes; JS Dlott; Douglas A Triplett; Peter M George
Gamma371 Thr-->Ile substitution in the fibrinogen gammaD domain causes hypofibrinogenaemia.
Biochimica et biophysica acta 2001;1550(2):183-8.
2001: M E Beard; H C Potter; Ruth Spearing; Stephen O Brennan
Haemoglobin Pierre-Benite--a high affinity variant associated with relative polycythaemia.
Clinical and laboratory haematology 2001;23(6):407-9.
2001: Rena M Hill; Stephen O Brennan; Nigel P Birch
Expression, purification, and functional characterization of the serine protease inhibitor neuroserpin expressed in Drosophila S2 cells.
Protein expression and purification 2001;22(3):406-13.
2001: DA Meh; Michael W Mosesson; Kevin R Siebenlist; P J Simpson-Haidaris; Stephen O Brennan; JP DiOrio; K Thompson; G Di Minno
Fibrinogen naples I (B beta A68T) nonsubstrate thrombin-binding capacities.
Thrombosis research 2001;103(1):63-73.
2001: DA Meh; Kevin R Siebenlist; Stephen O Brennan; T Holyst; Michael W Mosesson
The amino acid sequence in fibrin responsible for high affinity thrombin binding.
Thrombosis and haemostasis 2001;85(3):470-4.
2001: Stephen O Brennan; JM Wyatt; S May; S De Caigney; Peter M George
Hypofibrinogenemia due to novel 316 Asp --> Tyr substitution in the fibrinogen Bbeta chain.
Thrombosis and haemostasis 2001;85(3):450-3.
2001: Stephen O Brennan; Andrew P Fellowes; Peter M George
Molecular mechanisms of hypo- and afibrinogenemia.
Annals of the New York Academy of Sciences 2001;936():91-100.
2001: Andrew P Fellowes; Stephen O Brennan; Peter M George
Identification and characterization of five new fibrinogen gene polymorphisms.
Annals of the New York Academy of Sciences 2001;936():536-41.
2001: Daniela Medicina; G Fabbretti; Stephen O Brennan; Peter M George; B Kudryk; Francesco Callea
Genetic and immunological characterization of fibrinogen inclusion bodies in patients with hepatic fibrinogen storage and liver disease.
Annals of the New York Academy of Sciences 2001;936():522-5.
2000: Stephen O Brennan; Peter M George
Three truncated forms of serum albumin associated with pancreatic pseudocyst.
Biochimica et biophysica acta 2000;1481(2):337-43.
2000: J Wyatt; Stephen O Brennan; S May; Peter M George
Hypofibrinogenaemia with compound heterozygosity for two gamma chain mutations - gamma 82 Ala-->Gly and an intron two GT-->AT splice site mutation.
Thrombosis and haemostasis 2000;84(3):449-52.
2000: Andrew P Fellowes; Stephen O Brennan; R Holme; Helge Stormorken; Frank Brosstad; Peter M George
Homozygous truncation of the fibrinogen A alpha chain within the coiled coil causes congenital afibrinogenemia.
Blood 2000;96(2):773-5.
2000: Stephen O Brennan; J Wyatt; Daniela Medicina; Francesco Callea; Peter M George
Fibrinogen brescia: hepatic endoplasmic reticulum storage and hypofibrinogenemia because of a gamma284 Gly-->Arg mutation.
The American journal of pathology 2000;157(1):189-96.
2000: Stephen O Brennan; Andrew P Fellowes; JM Faed; Peter M George
Hypofibrinogenemia in an individual with 2 coding (gamma82 A-->G and Bbeta235 P-->L) and 2 noncoding mutations.
Blood 2000;95(5):1709-13.
2000: Stephen O Brennan; JM Wyatt; Paul Ockelford; Peter M George
Defective fibrinogen polymerization associated with a novel gamma279Ala-->Asp mutation.
British journal of haematology 2000;108(2):236-40.
1999: Victoria J Metcalf; Stephen O Brennan; Peter M George
The Antarctic toothfish (Dissostichus mawsoni) lacks plasma albumin and utilises high density lipoprotein as its major palmitate binding protein.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 1999;124(2):147-55.
1999: Stephen O Brennan; Andrew P Fellowes; Peter M George
Albumin banks peninsula: a new termination variant characterised by electrospray mass spectrometry.
Biochimica et biophysica acta 1999;1433(1-2):321-6.
1999: Victoria J Metcalf; Stephen O Brennan; G Chambers; Peter M George
High density lipoprotein (HDL), and not albumin, is the major palmitate binding protein in New Zealand long-finned (Anguilla dieffenbachii) and short-finned eel (Anguilla australis schmidtii) plasma.
Biochimica et biophysica acta 1999;1429(2):467-75.
1998: Stephen O Brennan
Electrospray ionization mass analysis of normal and genetic variants of human serum albumin.
Clinical chemistry 1998;44(11):2264-9.
1998: Stephen O Brennan; R M Loreth; Peter M George
Oligosaccharide configuration of fibrinogen Kaiserslautern: electrospray ionisation analysis of intact gamma chains.
Thrombosis and haemostasis 1998;80(2):263-5.
1998: Victoria J Metcalf; Stephen O Brennan; G K Chambers; Peter M George
The albumin of the brown trout (Salmo trutta) is a glycoprotein.
Biochimica et biophysica acta 1998;1386(1):90-6.
1998: Andrew P Fellowes; Stephen O Brennan; HJ Ridgway; D C Heaton; Peter M George
Electrospray ionization mass spectrometry identification of fibrinogen Banks Peninsula (gamma280Tyr-->Cys): a new variant with defective polymerization.
British journal of haematology 1998;101(1):24-31.
1998: E K Chua; Stephen O Brennan; Peter M George
Albumin Church Bay: 560 Lys-->Glu a new mutation detected by electrospray ionisation mass spectrometry.
Biochimica et biophysica acta 1998;1382(2):305-10.
1997: Stephen O Brennan; B Hammonds; Ruth Spearing; Peter M George
Electrospray ionisation mass spectrometry facilitates detection of fibrinogen (Bbeta 14 Arg --> Cys) mutation in a family with thrombosis.
Thrombosis and haemostasis 1997;78(6):1484-7.
1997: HJ Ridgway; Stephen O Brennan; R M Loreth; Peter M George
Fibrinogen Kaiserslautern (gamma 380 Lys to Asn): a new glycosylated fibrinogen variant with delayed polymerization.
British journal of haematology 1997;99(3):562-9.
1997: HJ Ridgway; Stephen O Brennan; Andrew P Fellowes; Peter M George
Rapid detection of the fibrinogen A alpha 16Arg --> His mutation.
Clinical chemistry 1997;43(11):2184-6.
1997: Henning Nielsen; Ulrich Kragh-Hansen; Lorenzo Minchiotti; Monica Galliano; Stephen O Brennan; AL Tárnoky; Maria Helena L P Franco; F M Salzano; O Sugita
Effect of genetic variation on the fatty acid-binding properties of human serum albumin and proalbumin.
Biochimica et biophysica acta 1997;1342(2):191-204.
1997: HJ Ridgway; Stephen O Brennan; JM Faed; Peter M George
Fibrinogen Otago: a major alpha chain truncation associated with severe hypofibrinogenaemia and recurrent miscarriage.
British journal of haematology 1997;98(3):632-9.
1997: Stephen O Brennan; J R Matthews
Hb Auckland [alpha 87(F8) His-->Asn]: a new mutation of the proximal histidine identified by electrospray mass spectrometry.
Hemoglobin 1997;21(5):393-403.
1997: Stephen O Brennan
Electrospray ionisation analysis of human fibrinogen.
Thrombosis and haemostasis 1997;78(3):1055-8.
1997: E C Ledgerwood; Stephen O Brennan; Peter M George
Endoproteases other than furin have a role in hepatic proprotein processing.
Biochemistry and molecular biology international 1997;42(6):1131-42.
1997: Christine C Winterbourn; Stephen O Brennan
Characterization of the oxidation products of the reaction between reduced glutathione and hypochlorous acid.
The Biochemical journal 1997;326 ( Pt 1)():87-92.
1997: Stephen O Brennan; HJ Ridgway; Helge Stormorken; Frank Brosstad; Peter M George
Characterisation of Fibrinogen Oslo IV by electrospray mass spectrometry.
Thrombosis and haemostasis 1997;77(5):1040-1.
1997: Lynley K Lewis; M W Smith; Stephen O Brennan; Timothy G Yandle; A Mark Richards; M Gary Nicholls
Degradation of human adrenomedullin(1-52) by plasma membrane enzymes and identification of metabolites.
Peptides 1997;18(5):733-9.
1996: Ulrich Kragh-Hansen; A O Pedersen; Monica Galliano; Lorenzo Minchiotti; Stephen O Brennan; A L Tárnoky; M H Franco; F M Salzano
High-affinity binding of laurate to naturally occurring mutants of human serum albumin and proalbumin.
The Biochemical journal 1996;320 ( Pt 3)():911-6.
1996: G R Hill; C M Hickton; Stephen O Brennan; C H Atkinson; D C Heaton
Acquired heparin-like anticoagulants: a second case in metastatic breast carcinoma and literature review.
Clinical and laboratory haematology 1996;18(4):291-5.
1996: E C Ledgerwood; Stephen O Brennan; Nigel P Birch; Peter M George
The specificity of the neuroendocrine convertase PC3 is determined by residues NH2- and COOH-terminal to the cleavage site.
Biochemistry and molecular biology international 1996;39(6):1167-76.
1996: HJ Ridgway; Stephen O Brennan; S Gibbons; Peter M George
Fibrinogen Lincoln: a new truncated alpha chain variant with delayed clotting.
British journal of haematology 1996;93(1):177-84.
1996: E C Ledgerwood; Stephen O Brennan; N X Cawley; Y P Loh; Peter M George
Yeast aspartic protease 3 (Yap3) prefers substrates with basic residues in the P2, P1 and P2' positions.
FEBS letters 1996;383(1-2):67-71.
1995: Stephen O Brennan; B Hammonds; Peter M George
Aberrant hepatic processing causes removal of activation peptide and primary polymerisation site from fibrinogen Canterbury (A alpha 20 Val --> Asp).
The Journal of clinical investigation 1995;96(6):2854-8.
1995: R M Hill; E C Ledgerwood; Stephen O Brennan; L P Pu; Y P Loh; David L Christie; Nigel P Birch
Comparison of the molecular forms of the Kex2/subtilisin-like serine proteases SPC2, SPC3, and furin in neuroendocrine secretory vesicles reveals differences in carboxyl-terminus truncation and membrane association.
Journal of neurochemistry 1995;65(5):2318-26.
1995: E C Ledgerwood; Peter M George; R J Peach; Stephen O Brennan
Endoproteolytic processing of recombinant proalbumin variants by the yeast Kex2 protease.
The Biochemical journal 1995;308 ( Pt 1)():321-5.
1994: Ulrich Kragh-Hansen; Stephen O Brennan; Lorenzo Minchiotti; Monica Galliano
Modified high-affinity binding of Ni2+, Ca2+ and Zn2+ to natural mutants of human serum albumin and proalbumin.
The Biochemical journal 1994;301 ( Pt 1)():217-23.
1994: Stephen O Brennan; K Nakayama
Cleavage of proalbumin peptides by furin reveals unexpected restrictions at the P2 and P'1 sites.
FEBS letters 1994;347(1):80-4.
1994: Stephen O Brennan; K Nakayama
Furin has the proalbumin substrate specificity and serpin inhibitory properties of an in situ hepatic convertase.
FEBS letters 1994;338(2):147-51.
1993: K C Fay; Stephen O Brennan; J M Costello; H C Potter; D A Williamson; R J Trent; Paul Ockelford; Ross Boswell
Haemoglobin Manukau beta 67[E11] Val-->Gly: transfusion-dependent haemolytic anaemia ameliorated by coexisting alpha thalassaemia.
British journal of haematology 1993;85(2):352-5.
1993: N W Rufaut; Stephen O Brennan; D J Hakes; J E Dixon; Nigel P Birch
Purification and characterization of the candidate prohormone-processing enzyme SPC3 produced in a mouse L cell line.
The Journal of biological chemistry 1993;268(27):20291-8.
1993: Stephen O Brennan; Andrew P Fellowes
Albumin Hawkes Bay; a low level variant caused by loss of a sulphydryl group at position 177.
Biochimica et biophysica acta 1993;1182(1):46-50.
1993: J B Wilson; Stephen O Brennan; J Allen; J G Shaw; LH Gu; TH Huisman
The M gamma chain of human fetal hemoglobin is an A gamma chain with an in vitro modification of gamma 141 leucine to hydroxyleucine.
Journal of chromatography 1993;617(1):37-42.
1993: Stephen O Brennan; J M Sheat; M Aiach
Circulating proalbumin associated with a second case of antitrypsin Pittsburgh.
Clinica chimica acta; international journal of clinical chemistry 1993;214(2):123-8.
1993: Stephen O Brennan; J G Shaw; Peter M George; T H Huisman
Posttranslational modification of beta 141 Leu associated with the beta 75(E19)Leu-->Pro mutation in Hb Atlanta.
Hemoglobin 1993;17(1):1-7.
1992: K Oda; Yoshio Misumi; Yukio Ikehara; Stephen O Brennan; K Hatsuzawa; K Nakayama
Proteolytic cleavages of proalbumin and complement Pro-C3 in vitro by a truncated soluble form of furin, a mammalian homologue of the yeast Kex2 protease.
Biochemical and biophysical research communications 1992;189(3):1353-61.
1992: P A Haynes; M Batley; R J Peach; Stephen O Brennan; JW Redmond
Characterisation of oligosaccharides from a glycoprotein variant of human serum albumin (albumin Casebrook) using high-performance anion-exchange chromatography and nuclear magnetic resonance spectroscopy.
Journal of chromatography 1992;581(2):187-93.
1992: R J Peach; Andrew P Fellowes; Stephen O Brennan; Peter M George
Albumin Rugby Park: a truncated albumin variant caused by a G-->C splice-site mutation in intron 13.
Biochimica et biophysica acta 1992;1180(1):107-10.
1992: E C Ledgerwood; Peter M George; I C Bathurst; Stephen O Brennan
The predicted proteinase furin is not the hepatic proalbumin convertase.
Biochimica et biophysica acta 1992;1159(1):9-12.
1992: R M G Wells; Stephen O Brennan
The detection and importance of functionally abnormal haemoglobins.
The New Zealand medical journal 1992;105(940):329-30.
1992: Stephen O Brennan; J Shaw; J Allen; Peter M George
Beta 141 Leu is not deleted in the unstable haemoglobin Atlanta-Coventry but is replaced by a novel amino acid of mass 129 daltons.
British journal of haematology 1992;81(1):99-103.
1992: Peter M George; Timothy Myles; D Williamson; R Higuchi; W A Symmans; Stephen O Brennan
A family with haemolytic anaemia and three beta-globins: the deletion in haemoglobin Atlanta-Coventry (beta 75 Leu----Pro, 141 Leu deleted) is not present at the nucleotide level.
British journal of haematology 1992;81(1):93-8.
1991: Stephen O Brennan; R J Peach
The processing of human proinsulin and chicken proalbumin by rat hepatic vesicles suggests a convertase specific for X-Y-Arg-Arg or Arg-X-Y-Arg sequences.
The Journal of biological chemistry 1991;266(32):21504-8.
1991: R J Peach; Ross Boswell; Stephen O Brennan
Prediction of the site of signal peptidase cleavage in normal and variant human preproalbumin.
Protein sequences & data analysis 1991;4(2):123-6.
1991: R J Peach; Stephen O Brennan
Structural characterization of a glycoprotein variant of human serum albumin: albumin Casebrook (494 Asp----Asn).
Biochimica et biophysica acta 1991;1097(1):49-54.
1991: Stephen O Brennan; J Y Borg; G J Shaw; J Caen; Peter M George
Functional antithrombin-III variant (41 Pro----Leu) identified by liquid secondary ion mass spectrometry.
Pathology 1991;23(1):1-4.
1991: Stephen O Brennan; I R Lowrey; M G Harris; R Rodwell; K Zarkos; T Wilkinson; J Yakas; H Kronenberg
Hb J-Camaguey [alpha 141(HC3)Arg----Gly] associated with alpha-thalassemia-1 in an Australian family.
Hemoglobin 1991;15(4):303-7.
1990: Stephen O Brennan; R J Peach; I C Bathurst
Specificity of yeast KEX2 protease for variant human proalbumins is identical to the in vivo specificity of the hepatic proalbumin convertase.
The Journal of biological chemistry 1990;265(35):21494-7.
1990: Ulrich Kragh-Hansen; Lorenzo Minchiotti; Stephen O Brennan; O Sugita
Hormone binding to natural mutants of human serum albumin.
European journal of biochemistry / FEBS 1990;193(1):169-74.
1990: J Y Borg; Stephen O Brennan; R W Carrell; Peter M George; D J Perry; J Shaw
Antithrombin Rouen-IV 24 Arg----Cys. The amino-terminal contribution to heparin binding.
FEBS letters 1990;266(1-2):163-6.
1990: Stephen O Brennan; K Arai; J Madison; C B Laurell; Monica Galliano; S Watkins; R Peach; Timothy Myles; Peter M George; F W Putnam
Hypermutability of CpG dinucleotides in the propeptide-encoding sequence of the human albumin gene.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(10):3909-13.
1990: Mark Wardell; SC Rall; Stephen O Brennan; E R Nye; Peter M George; E D Janus; Karl H Weisgraber
Apolipoprotein E2-Dunedin (228 Arg replaced by Cys): an apolipoprotein E2 variant with normal receptor-binding activity.
Journal of lipid research 1990;31(3):535-43.
1990: Ulrich Kragh-Hansen; Stephen O Brennan; Monica Galliano; O Sugita
Binding of warfarin, salicylate, and diazepam to genetic variants of human serum albumin with known mutations.
Molecular pharmacology 1990;37(2):238-42.
1990: D Williamson; J Nutkins; S Rosthoj; Stephen O Brennan; D H Williams; R W Carrell
Characterization of Hb Aalborg, a new unstable hemoglobin variant, by fast atom bombardment mass spectrometry.
Hemoglobin 1990;14(2):137-45.
1990: Stephen O Brennan; Timothy Myles; R J Peach; D Donaldson; Peter M George
Albumin Redhill (-1 Arg, 320 Ala----Thr): a glycoprotein variant of human serum albumin whose precursor has an aberrant signal peptidase cleavage site.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(1):26-30.
1989: Stephen O Brennan; R J Peach; Ross Boswell
Novel human proalbumin variant with intact dibasic sequence facilitates identification of its converting enzyme.
Biochimica et biophysica acta 1989;993(1):48-50.
1989: S P McCormick; Andrew P Fellowes; Stephen O Brennan; Peter M George
Apolipoprotein E variation in patients with hyperlipidaemia: DNA and protein phenotyping.
The New Zealand medical journal 1989;102(877):534-6.
1989: C J Rhodes; Stephen O Brennan; John C Hutton
Proalbumin to albumin conversion by a proinsulin processing endopeptidase of insulin secretory granules.
The Journal of biological chemistry 1989;264(24):14240-5.
1989: Timothy G Yandle; Stephen O Brennan; Eric A Espiner; M G Nicholls; A Mark Richards
Endopeptidase-24.11 in human plasma degrades atrial natriuretic factor (ANF) to ANF(99-105/106-126).
Peptides 1989;10(4):891-4.
1989: R J Peach; Stephen O Brennan
Identification of a calcium-dependent microsomal proteinase responsible for monobasic cleavage of chicken proalbumin.
Biochimica et biophysica acta 1989;990(3):276-9.
1989: Stephen O Brennan
Propeptide cleavage: evidence from human proalbumins.
Molecular biology & medicine 1989;6(1):87-92.
1988: Stephen O Brennan; J Y Borg; Peter M George; C Soria; J Soria; J Caen; R W Carrell
New carbohydrate site in mutant antithrombin (7 Ile----Asn) with decreased heparin affinity.
FEBS letters 1988;237(1-2):118-22.
1988: Stephen O Brennan; Peter M George; R J Peach
Characterisation of a slow component of normal human serum albumin.
Clinica chimica acta; international journal of clinical chemistry 1988;176(2):179-84.
1988: Margret C M Vissers; Peter M George; I C Bathurst; Stephen O Brennan; Christine C Winterbourn
Cleavage and inactivation of alpha 1-antitrypsin by metalloproteinases released from neutrophils.
The Journal of clinical investigation 1988;82(2):706-11.
1988: Stephen O Brennan; R J Peach
Calcium-dependent KEX2-like protease found in hepatic secretory vesicles converts proalbumin to albumin.
FEBS letters 1988;229(1):167-70.
1987: Mark Wardell; Stephen O Brennan; E D Janus; R Fraser; R W Carrell
Apolipoprotein E2-Christchurch (136 Arg----Ser). New variant of human apolipoprotein E in a patient with type III hyperlipoproteinemia.
The Journal of clinical investigation 1987;80(2):483-90.
1987: Stephen O Brennan; Peter M George; R E Jordan
Physiological variant of antithrombin-III lacks carbohydrate sidechain at Asn 135.
FEBS letters 1987;219(2):431-6.
1987: Stephen O Brennan; P Herbert
Albumin Canterbury (313 Lys----Asn). A point mutation in the second domain of serum albumin.
Biochimica et biophysica acta 1987;912(2):191-7.
1987: I C Bathurst; Stephen O Brennan; R W Carrell; L S Cousens; A J Brake; P J Barr
Yeast KEX2 protease has the properties of a human proalbumin converting enzyme.
Science (New York, N.Y.) 1987;235(4786):348-50.
1987: T Wilkinson; P Como; P Brock; H Kronenberg; Ronald J Trent; Stephen O Brennan
Hemoglobin I High Wycombe in an Australian family.
Hemoglobin 1987;11(1):51-3.
1986: Stephen O Brennan; R W Carrell
alpha 1-Antitrypsin Christchurch, 363 Glu----Lys: mutation at the P'5 position does not affect inhibitory activity.
Biochimica et biophysica acta 1986;873(1):13-9.
1986: Stephen O Brennan; D Williamson; W A Symmans; R W Carrell
Two de novo mutations in one beta globin chain: hemoglobin Atlanta-Coventry, beta 75 Leu----Pro and beta 141 Leu deleted.
Hemoglobin 1986;10(3):225-37.
1985: Stephen O Brennan
The molecular abnormality of albumin Parklands: 365 Asp----His.
Biochimica et biophysica acta 1985;830(3):320-4.
1985: D Williamson; M E Whisson; M Whineray; R M Wells; Stephen O Brennan; R W Carrell
Polycythaemia associated with a new haemoglobin variant: haemoglobin Palmerston North beta 23 (B5) val----phe.
The New Zealand medical journal 1985;98(783):585-7.
1985: Stephen O Brennan
The separation of globin chains by high pressure cation exchange chromatography.
Hemoglobin 1985;9(1):53-63.
1984: Stephen O Brennan; M C Owen; Ross Boswell; J H Lewis; R W Carrell
Circulating proalbumin associated with a variant proteinase inhibitor.
Biochimica et biophysica acta 1984;802(1):24-8.
1984: D Williamson; Stephen O Brennan; H Strosberg; J Whitty; R W Carrell
Hemoglobin A2 Fitzroy delta 142 Ala----Asp: a new delta-chain variant.
Hemoglobin 1984;8(4):325-32.
1984: Stephen O Brennan; D Williamson; M B Smith; M N Cauchi; A Macphee; R W Carrell
HbA2 Victoria delta 24 (B6) Gly----Asp. A new delta chain variant occurring with beta-thalassemia.
Hemoglobin 1984;8(2):163-8.
1984: R W Carrell; I C Bathurst; Stephen O Brennan
The molecular pathology of human alpha 1-antitrypsin.
Biochemical Society symposium 1984;49():55-66.
1983: M C Owen; Stephen O Brennan; J H Lewis; R W Carrell
Mutation of antitrypsin to antithrombin. alpha 1-antitrypsin Pittsburgh (358 Met leads to Arg), a fatal bleeding disorder.
The New England journal of medicine 1983;309(12):694-8.
1983: Ross Boswell; J O Jeppsson; Stephen O Brennan; R W Carrell
The reactive site of alpha 1-antitrypsin is C-terminal, not N-terminal.
Biochimica et biophysica acta 1983;744(2):212-8.
1983: D Williamson; Stephen O Brennan; R W Carrell
Hb Brisbane (beta 68 (E12) Leu replaced by His) is unstable.
Hemoglobin 1983;7(5):473-5.
1983: Stephen O Brennan; D Williamson; W A Symmans; R W Carrell
Two unstable hemoglobins in one individual: Hb Atlanta (beta 75 Leu leads to Pro) and Hb Coventry (beta 141 Leu deleted).
Hemoglobin 1983;7(4):303-12.
1983: D Williamson; Stephen O Brennan; H Muir; R W Carrell
Hemoglobin Collingwood beta 60 (E4) Val replaced by Ala. A new unstable hemoglobin.
Hemoglobin 1983;7(6):511-9.
1982: R W Carrell; J O Jeppsson; C B Laurell; Stephen O Brennan; M C Owen; L Vaughan; Ross Boswell
Structure and variation of human alpha 1-antitrypsin.
Nature 1982;298(5872):329-34.
1982: Stephen O Brennan; D Williamson; M E Whisson; R W Carrell
Hemoglobin Palmerston North beta 23 (B5) Val replaced by Phe. A new variant identified in a patient with polycythemia.
Hemoglobin 1982;6(6):569-75.
1981: R W Carrell; J O Jeppsson; L Vaughan; Stephen O Brennan; M C Owen; Ross Boswell
Human alpha 1-antitrypsin: carbohydrate attachment and sequence homology.
FEBS letters 1981;135(2):301-3.
1981: Stephen O Brennan; R M Wells; H Smith; R W Carrell
Hemoglobin Brisbane: beta68 Leu replaced by His. A new high oxygen affinity variant.
Hemoglobin 1981;5(4):325-35.
1980: R G Reed; T Peters; Stephen O Brennan; R W Carrell
Ligand-binding properties of proalbumin Christchurch.
The Biochemical journal 1980;191(1):281-3.
1980: R W Carrell; Ross Boswell; Stephen O Brennan; M C Owen
Active site of alpha 1-antitrypsin: homologous site in antithrombin-III.
Biochemical and biophysical research communications 1980;93(2):399-402.
1980: Stephen O Brennan; R W Carrell
Functional abnormality of proalbumin Christchurch.
Biochimica et biophysica acta 1980;621(1):83-8.
1980: P A Ockelford; A Y Liang; R M Wells; M Vissers; Stephen O Brennan; D Williamson; R W Carrell
Hemoglobin Volga, beta 27 (B9) Ala replaced by Asp: functional and clinical correlations of an unstable hemoglobin.
Hemoglobin 1980;4(3-4):295-306.
1980: T Wilkinson; Stephen O Brennan; R W Carrell; R M Wells; P Como; H Kronenberg
Hemoglobin Summer Hill beta 52(D3) Asp leads to His a new variant from Sydney, Australia.
Hemoglobin 1980;4(2):185-93.
1979: M E Beard; J W Hamer; Stephen O Brennan; J N Jones; J M Sheat; J S Maclaurin
Familial relative polycythaemia due to haemoglobin Heathrow.
Australian and New Zealand journal of medicine 1979;9(3):297-301.
1978: Stephen O Brennan; R W Carrell
A circulating variant of human proalbumin.
Nature 1978;274(5674):908-9.
1977: Stephen O Brennan; K O Jones; L Crethar; B J Arnold; P J Fleming; C C Winterbourn
Haemoglobin North Shore, beta134 Val replaced by Glu, a new unstable haemoglobin.
Biochimica et biophysica acta 1977;494(2):403-7.
1977: Stephen O Brennan; G P Tauro; W Melrose
Haemoglobin Port Phillip alpha91 (FG3) Leu replaced by Pro, a new unstable haemoglobin.
FEBS letters 1977;81(1):115-7.
1977: Stephen O Brennan; M B Smith; R W Carrell
Haemoglobin F Melbourne Ggamma 16 Gly leads to Arg and haemoglobin F carlton Ggamma 121 Glu leads to Lys. Further evidence for varied activity of gamma-chain genes.
Biochimica et biophysica acta 1977;490(2):452-5.
1977: Stephen O Brennan
Absolute identification of Hb D-Los Angeles (beta121 Glu replaced by Gln).
Hemoglobin 1977;1(6):571-6.
1977: Stephen O Brennan; C C Winterbourn; R W Carrell
Isolation of high oxygen affinity hemoglobins.
Hemoglobin 1977;1(5):479-85.
1976: M C Owen; R W Carrell; Stephen O Brennan
The abnormality of the S variant of human alpha-1-antitrypsin.
Biochimica et biophysica acta 1976;453(1):257-61.
1974: Stephen O Brennan; P F Davis; G G Midwinter
Structural aspects of sheep-heart phosphofructokinase.
European journal of biochemistry / FEBS 1974;42(2):489-94.