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Tom Brown

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Lisha Wu; Tom Brown; Krzysztof Kazimierczuk; Per Lincoln; Bengt Nordén; Cecilia Persson; Anna Reymer; Martin Billeter
Initial DNA Interactions of the Binuclear Threading Intercalator Λ,Λ-[μ-bidppz(bipy)4 Ru2 ](4+) : An NMR Study with [d(CGCGAATTCGCG)]2.
James A Milton; Samson Patole; Qiang Xiao; Huabing Yin; Tom Brown; Tracy Melvin
Efficient self-assembly of DNA-functionalized fluorophores and gold nanoparticles with DNA functionalized silicon surfaces: the effect of oligomer spacers.
Jonas K Hannestad; Aldo Jesorka; Bo Albinsson; Tom Brown; Ralf Brune; Ilja Czolkos; Afaf H El-Sagheer; Owe Orwar
Kinetics of diffusion-mediated DNA hybridization in lipid monolayer films determined by single-molecule fluorescence spectroscopy.

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2013: Lisha Wu; Tom Brown; Krzysztof Kazimierczuk; Per Lincoln; Bengt Nordén; Cecilia Persson; Anna Reymer; Martin Billeter
Initial DNA Interactions of the Binuclear Threading Intercalator Λ,Λ-[μ-bidppz(bipy)4 Ru2 ](4+) : An NMR Study with [d(CGCGAATTCGCG)]2.
Chemistry (Weinheim an der Bergstrasse, Germany) 2013;19(17):5401-10.
2013: James A Milton; Samson Patole; Qiang Xiao; Huabing Yin; Tom Brown; Tracy Melvin
Efficient self-assembly of DNA-functionalized fluorophores and gold nanoparticles with DNA functionalized silicon surfaces: the effect of oligomer spacers.
Nucleic acids research 2013;41(7):e80.
2013: Jonas K Hannestad; Aldo Jesorka; Bo Albinsson; Tom Brown; Ralf Brune; Ilja Czolkos; Afaf H El-Sagheer; Owe Orwar
Kinetics of diffusion-mediated DNA hybridization in lipid monolayer films determined by single-molecule fluorescence spectroscopy.
ACS nano 2013;7(1):308-15.
2012: Jo-Anne Riley; Tom Brown; Nittaya Gale; Julie M Herniman; G John Langley
Self reporting RNA probes as an alternative to cleavable small molecule mass tags.
The Analyst 2012;137(24):5817-22.
2012: Montserrat Shelbourne; Afaf H El-Sagheer; Tom Brown; Tom Brown
Fast and efficient DNA crosslinking and multiple orthogonal labelling by copper-free click chemistry.
Chemical communications (Cambridge, England) 2012;48(91):11184-6.
2012: A Pia Sanzone; Tom Brown; Afaf H El-Sagheer; Ali Tavassoli
Assessing the biocompatibility of click-linked DNA in Escherichia coli.
Nucleic acids research 2012;40(20):10567-75.
2012: Simon R Gerrard; Claire Hardiman; Iris Nandhakumar; Bengt Nordén; Montserrat Shelbourne; Tom Brown
A new modular approach to nanoassembly: stable and addressable DNA nanoconstructs via orthogonal click chemistries.
ACS nano 2012;6(10):9221-8.
2012: David A Rusling; Iris S Nandhakumar; Tom Brown; Keith R Fox
Triplex-directed covalent cross-linking of a DNA nanostructure.
Chemical communications (Cambridge, England) 2012;48(77):9592-4.
2012: Niklas Bosaeus; Tom Brown; Carlos Bustamante; Afaf H El-Sagheer; Björn Akerman; Steven B Smith; Bengt Nordén
Tension induces a base-paired overstretched DNA conformation.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(38):15179-84.
2012: Robert P Johnson; James A Richardson; Tom Brown; Philip N Bartlett
A label-free, electrochemical SERS-based assay for detection of DNA hybridization and discrimination of mutations.
Journal of the American Chemical Society 2012;134(34):14099-107.
2012: Afaf H El-Sagheer; Tom Brown
Click nucleic acid ligation: applications in biology and nanotechnology.
Accounts of chemical research 2012;45(8):1258-67.
2012: Lucy M Hall; Marta Gerowska; Tom Brown
A highly fluorescent DNA toolkit: synthesis and properties of oligonucleotides containing new Cy3, Cy5 and Cy3B monomers.
Nucleic acids research 2012;40(14):e108.
2012: Anke Dierckx; Francois-Alexandre Miannay; Søren Preus; Nouha Ben Gaied; Markus Björck; Tom Brown; L Marcus Wilhelmsson
Quadracyclic adenine: a non-perturbing fluorescent adenine analogue.
Chemistry (Weinheim an der Bergstrasse, Germany) 2012;18(19):5987-97.
2012: David A Rusling; Iris S Nandhakumar; Tom Brown; Keith R Fox
Triplex-directed recognition of a DNA nanostructure assembled by crossover strand exchange.
ACS nano 2012;6(4):3604-13.
2012: Antonia S Cardew; Tom Brown; Keith R Fox
Secondary binding sites for heavily modified triplex forming oligonucleotides.
Nucleic acids research 2012;40(8):3753-62.
2012: Robert P Johnson; James A Richardson; Tom Brown; Philip N Bartlett
Real-time surface-enhanced Raman spectroscopy monitoring of surface pH during electrochemical melting of double-stranded DNA.
Langmuir : the ACS journal of surfaces and colloids 2012;28(12):5464-70.
2011: Afaf H el-Sagheer; Tom Brown
Efficient RNA synthesis by in vitro transcription of a triazole-modified DNA template.
Chemical communications (Cambridge, England) 2011;47(44):12057-8.
2011: Jonas K Hannestad; Tom Brown; Simon R Gerrard; Bo Albinsson
Self-assembled DNA-based fluorescence waveguide with selectable output.
Small (Weinheim an der Bergstrasse, Germany) 2011;7(22):3178-85.
2011: Ilona Węgrzyn; Martin Katterle; Birgit Nagel; Owe Orwar; Tom Brown; Simon R Gerrard; Gavin D M Jeffries; Aldo Jesorka
Membrane protrusion coarsening and nanotubulation within giant unilamellar vesicles.
Journal of the American Chemical Society 2011;133(45):18046-9.
2011: Erik P Lundberg; Tom Brown; Per Lincoln; Calin Plesa; L Marcus Wilhelmsson; Bengt Nordén
Nanofabrication yields. Hybridization and click-fixation of polycyclic DNA nanoassemblies.
ACS nano 2011;5(9):7565-75.
2011: Afaf H El-Sagheer; Rachel Gao; A Pia Sanzone; Ali Tavassoli; Tom Brown
Biocompatible artificial DNA linker that is read through by DNA polymerases and is functional in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(28):11338-43.
2011: Montserrat Shelbourne; Xiong Chen; Tom Brown; Afaf H El-Sagheer
Fast copper-free click DNA ligation by the ring-strain promoted alkyne-azide cycloaddition reaction.
Chemical communications (Cambridge, England) 2011;47(22):6257-9.
2011: Anke Dierckx; Peter Dinér; Afaf H El-Sagheer; Joshi Dhruval Kumar; Tom Brown; Morten Grøtli; L Marcus Wilhelmsson
Characterization of photophysical and base-mimicking properties of a novel fluorescent adenine analogue in DNA.
Nucleic acids research 2011;39(10):4513-24.
2011: Rohan T Ranasinghe; Tom Brown
Ultrasensitive fluorescence-based methods for nucleic acid detection: towards amplification-free genetic analysis.
Chemical communications (Cambridge, England) 2011;47(13):3717-35.
2011: Keith R Fox; Tom Brown
Formation of stable DNA triplexes.
Biochemical Society transactions 2011;39(2):629-34.
2011: Afaf H El-Sagheer; Vee Vee Cheong; Tom Brown
Rapid chemical ligation of oligonucleotides by the Diels-Alder reaction.
Organic & biomolecular chemistry 2011;9(1):232-5.
2010: James A Richardson; Marta Gerowska; Montserrat Shelbourne; David French; Tom Brown
Six-colour HyBeacon probes for multiplex genetic analysis.
Chembiochem : a European journal of chemical biology 2010;11(18):2530-3.
2010: Simon R Gerrard; Mastoura M Edrees; Imenne Bouamaied; Keith R Fox; Tom Brown
CG base pair recognition within DNA triple helices by modified N-methylpyrrolo-dC nucleosides.
Organic & biomolecular chemistry 2010;8(22):5087-96.
2010: Karl Börjesson; Joanna Wiberg; Afaf H El-Sagheer; Thomas Ljungdahl; Jerker Mårtensson; Tom Brown; Bengt Nordén; Bo Albinsson
Functionalized nanostructures: redox-active porphyrin anchors for supramolecular DNA assemblies.
ACS nano 2010;4(9):5037-46.
2010: Chenguang Lou; Qiang Xiao; Lavinia Brennan; Mark E Light; Nuria Vergara-Irigaray; Elizabeth M Atkinson; Lindy M Holden-Dye; Keith R Fox; Tom Brown
Synthesis and properties of triplex-forming oligonucleotides containing 2'-O-(2-methoxyethyl)-5-(3-aminoprop-1-ynyl)-uridine.
Bioorganic & medicinal chemistry 2010;18(17):6389-97.
2010: Afaf H El-Sagheer; Tom Brown
New strategy for the synthesis of chemically modified RNA constructs exemplified by hairpin and hammerhead ribozymes.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(35):15329-34.
2010: Damion Corrigan; Nittaya Gale; Tom Brown; Philip N Bartlett
Analysis of short tandem repeats by using SERS monitoring and electrochemical melting.
Angewandte Chemie (International ed. in English) 2010;49(34):5917-20.
2010: Nouha Ben Gaied; James A Richardson; Daniel G Singleton; Zhengyun Zhao; David French; Tom Brown
End-capped HyBeacon probes for the analysis of human genetic polymorphisms related to warfarin metabolism.
Organic & biomolecular chemistry 2010;8(12):2728-34.
2010: Erik P Lundberg; Afaf H El-Sagheer; Petr Kocalka; L Marcus Wilhelmsson; Tom Brown; Bengt Nordén
A new fixation strategy for addressable nano-network building blocks.
Chemical communications (Cambridge, England) 2010;46(21):3714-6.
2010: F Gambinossi; Martina Banchelli; Adeline Durand; Debora Berti; Tom Brown; Gabriella Caminati; Piero Baglioni
Modulation of density and orientation of amphiphilic DNA anchored to phospholipid membranes. I. Supported lipid bilayers.
The journal of physical chemistry. B 2010;114(21):7338-47.
2010: Martina Banchelli; F Gambinossi; Adeline Durand; Gabriella Caminati; Tom Brown; Debora Berti; Piero Baglioni
Modulation of density and orientation of amphiphilic DNA on phospholipid membranes. II. Vesicles.
The journal of physical chemistry. B 2010;114(21):7348-58.
2010: Afaf H El-Sagheer; Tom Brown
Click chemistry with DNA.
Chemical Society reviews 2010;39(4):1388-405.
2010: P Glynne-Jones; R J Boltryk; Martyn Hill; F Zhang; L Dong; James S Wilkinson; Tom Brown; Tracy Melvin; N R Harris
Multi-modal particle manipulator to enhance bead-based bioassays.
Ultrasonics 2010;50(2):235-9.
2009: David A Rusling; Phillip A Rachwal; Tom Brown; Keith R Fox
The stability of triplex DNA is affected by the stability of the underlying duplex.
Biophysical chemistry 2009;145(2-3):105-10.
2009: Nouha Ben Gaied; Zhengyun Zhao; Simon R Gerrard; Keith R Fox; Tom Brown
Potent triple helix stabilization by 5',3'-modified triplex-forming oligonucleotides.
Chembiochem : a European journal of chemical biology 2009;10(11):1839-51.
2009: Ilja Czolkos; Jonas K Hannestad; Aldo Jesorka; Ravindra Kumar; Tom Brown; Bo Albinsson; Owe Orwar
Platform for controlled supramolecular nanoassembly.
Nano letters 2009;9(6):2482-6.
2009: Quan-Hong Yang; Qi Wang; Nittaya Gale; Claudio J Oton; Lan Cui; Iris S Nandhakumar; Zhenping Zhu; Zhiyuan Tang; Tom Brown; Wei H Loh
Loosening the DNA wrapping around single-walled carbon nanotubes by increasing the strand length.
Nanotechnology 2009;20(19):195603.
2009: Karl Börjesson; Søren Preus; Afaf H El-Sagheer; Tom Brown; Bo Albinsson; L Marcus Wilhelmsson
Nucleic acid base analog FRET-pair facilitating detailed structural measurements in nucleic acid containing systems.
Journal of the American Chemical Society 2009;131(12):4288-93.
2009: Afaf H El-Sagheer; Tom Brown
Synthesis and polymerase chain reaction amplification of DNA strands containing an unnatural triazole linkage.
Journal of the American Chemical Society 2009;131(11):3958-64.
2009: Karl Börjesson; John Tumpane; Thomas Ljungdahl; L Marcus Wilhelmsson; Bengt Nordén; Tom Brown; Jerker Mårtensson; Bo Albinsson
Membrane-anchored DNA assembly for energy and electron transfer.
Journal of the American Chemical Society 2009;131(8):2831-9.
2009: David A Rusling; Guomei Peng; Natarajan Srinivasan; Keith R Fox; Tom Brown
DNA triplex formation with 5-dimethylaminopropargyl deoxyuridine.
Nucleic acids research 2009;37(4):1288-96.
2009: Peter Glynne-Jones; Rosemary J Boltryk; Martyn Hill; Fan Zhang; Liqin Dong; James S Wilkinson; Tracy Melvin; Nicholas R Harris; Tom Brown
Flexible acoustic particle manipulation device with integrated optical waveguide for enhanced microbead assays.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 2009;25(2):285-91.
2008: Nittaya Gale; David J French; Rebecca Howard; David G McDowell; Paul G Debenham; Tom Brown
Rapid typing of STRs in the human genome by HyBeacon melting.
Organic & biomolecular chemistry 2008;6(24):4553-9.
2008: Ross Stevenson; Helen C Baxter; Alastair Aitken; Tom Brown; Robert L Baxter
Binding of 14-3-3 proteins to a single stranded oligodeoxynucleotide aptamer.
Bioorganic chemistry 2008;36(5):215-9.
2008: Petr Kocalka; Afaf H El-Sagheer; Tom Brown
Rapid and efficient DNA strand cross-linking by click chemistry.
Chembiochem : a European journal of chemical biology 2008;9(8):1280-5.
2008: David A Rusling; Victoria J Broughton-Head; Alex Tuck; Hannah Khairallah; Sadie D Osborne; Tom Brown; Keith R Fox
Kinetic studies on the formation of DNA triplexes containing the nucleoside analogue 2'-O-(2-aminoethyl)-5-(3-amino-1-propynyl)uridine.
Organic & biomolecular chemistry 2008;6(1):122-9.
2008: Afaf H El-Sagheer; Ravindra Kumar; Stuart Findlow; Joern Werner; Andrew N Lane; Tom Brown
A very stable cyclic DNA miniduplex with just two base pairs.
Chembiochem : a European journal of chemical biology 2008;9(1):50-2.
2008: Karl Börjesson; John Tumpane; Thomas Ljungdahl; L Marcus Wilhelmsson; Bengt Nordén; Tom Brown; Jerker Mårtensson; Bo Albinsson
A membrane anchored DNA-based energy/electron transfer assembly.
Nucleic acids symposium series (2004) 2008;(52):691.
2008: Erik Lundberg; John Tumpane; Ravindra Kumar; Peter Sandin; Nittaya Gale; Iris S Nandhakumar; Bo Albinsson; Per Lincoln; L Marcus Wilhelmsson; Tom Brown; Bengt Nordén
Addressable molecular node assembly--high information density DNA nanostructures.
Nucleic acids symposium series (2004) 2008;(52):683-4.
2008: Karl Börjesson; Peter Sandin; Bo Albinsson; Jerker Mårtensson; Tom Brown; L Marcus Wilhelmsson
Characterization and use of tricyclic fluorescent nucleic acid base analogues.
Nucleic acids symposium series (2004) 2008;(52):3-4.
2008: Yavuz Erkan; Kiona Halma; Ilja Czolkos; Aldo Jesorka; Paul Dommersnes; Ravindra Kumar; Tom Brown; Owe Orwar
Controlled release of chol-TEG-DNA from Nano- and micropatterned SU-8 surfaces by a spreading lipid film.
Nano letters 2008;8(1):227-31.
2008: Peter Sandin; Karl Börjesson; Hong Li; Jerker Mårtensson; Tom Brown; L Marcus Wilhelmsson; Bo Albinsson
Characterization and use of an unprecedentedly bright and structurally non-perturbing fluorescent DNA base analogue.
Nucleic acids research 2008;36(1):157-67.
2007: John Tumpane; Ravindra Kumar; Erik P Lundberg; Peter Sandin; Nittaya Gale; Iris S Nandhakumar; Bo Albinsson; Per Lincoln; L Marcus Wilhelmsson; Tom Brown; Bengt Nordén
Triplex addressability as a basis for functional DNA nanostructures.
Nano letters 2007;7(12):3832-9.
2007: Naomi Hammond; Peter Koumi; G John Langley; Alex Lowe; Tom Brown
Rapid mass spectrometric identification of human genomic polymorphisms using multiplexed photocleavable mass-tagged probes and solid phase capture.
Organic & biomolecular chemistry 2007;5(12):1878-85.
2007: Ravindra Kumar; Afaf El-Sagheer; John Tumpane; Per Lincoln; L Marcus Wilhelmsson; Tom Brown
Template-directed oligonucleotide strand ligation, covalent intramolecular DNA circularization and catenation using click chemistry.
Journal of the American Chemical Society 2007;129(21):6859-64.
2007: Phillip A Rachwal; Tom Brown; Keith R Fox
Sequence effects of single base loops in intramolecular quadruplex DNA.
FEBS letters 2007;581(8):1657-60.
2007: Phillip A Rachwal; Tom Brown; Keith R Fox
Effect of G-tract length on the topology and stability of intramolecular DNA quadruplexes.
Biochemistry 2007;46(11):3036-44.
2007: Adeline Durand; Tom Brown
Synthesis and properties of oligonucleotides containing a cholesterol thymidine monomer.
Nucleosides, nucleotides & nucleic acids 2007;26(6-7):785-94.
2007: Simon R Gerrard; Natarajan Srinivasan; Keith R Fox; Tom Brown
CG base pair recognition within DNA triple helices using N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1363-7.
2007: Lavinia Brennan; Guomei Peng; Natarajan Srinivasan; Keith R Fox; Tom Brown
2'-o-dimethylaminoethoxyuridine and 5-dimethylaminopropargyl deoxyuridine for at base pair recognition in triple helices.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1283-6.
2007: Hong Li; Victoria J Broughton-Head; Keith R Fox; Tom Brown
Photoinduced crosslinking of double-helical DNA by psoralen covalently linked to a triple helix-forming oligonucleotide under near-physiological conditions.
Nucleosides, nucleotides & nucleic acids 2007;26(8-9):1005-9.
2007: Zhengyun Zhao; Guomei Peng; Jan Michels; Keith R Fox; Tom Brown
Synthesis of anthraquinone oligonucleotides for triplex stabilization.
Nucleosides, nucleotides & nucleic acids 2007;26(8-9):921-5.
2007: Phillip A Rachwal; I Stuart Findlow; Joern Werner; Tom Brown; Keith R Fox
Intramolecular DNA quadruplexes with different arrangements of short and long loops.
Nucleic acids research 2007;35(12):4214-22.
2007: Peter Sandin; Per Lincoln; Tom Brown; L Marcus Wilhelmsson
Synthesis and oligonucleotide incorporation of fluorescent cytosine analogue tC: a promising nucleic acid probe.
Nature protocols 2007;2(3):615-23.
2006: Hong Li; Victoria J Broughton-Head; Guomei Peng; Vicki E C Powers; Matthew J Ovens; Keith R Fox; Tom Brown
Triplex staples: DNA double-strand cross-linking at internal and terminal sites using psoralen-containing triplex-forming oligonucleotides.
Bioconjugate chemistry 2006;17(6):1561-7.
2006: David A Rusling; Tom Brown; Keith R Fox
DNA triple-helix formation at target sites containing duplex mismatches.
Biophysical chemistry 2006;123(2-3):134-40.
2006: Andrew J Hampshire; Hannah Khairallah; Abedawn I Khalaf; Abdolrasoul Haghir Ebrahimabadi; Roger D Waigh; Colin J Suckling; Tom Brown; Keith R Fox
DNA sequence recognition by an imidazole-containing isopropyl-substituted thiazole polyamide (thiazotropsin B).
Bioorganic & medicinal chemistry letters 2006;16(13):3469-74.
2005: David A Rusling; Loic Le Strat; Vicki E C Powers; Victoria J Broughton-Head; James Booth; Oliver Lack; Tom Brown; Keith R Fox
Combining nucleoside analogues to achieve recognition of oligopurine tracts by triplex-forming oligonucleotides at physiological pH.
FEBS letters 2005;579(29):6616-20.
2005: Rohan T Ranasinghe; Tom Brown
Fluorescence based strategies for genetic analysis.
Chemical communications (Cambridge, England) 2005;(44):5487-502.
2005: Nicholas M Brown; Phillip A Rachwal; Tom Brown; Keith R Fox
Exceptionally slow kinetics of the intramolecular quadruplex formed by the Oxytricha telomeric repeat.
Organic & biomolecular chemistry 2005;3(22):4153-7.
2005: Keith R Fox; Tom Brown
An extra dimension in nucleic acid sequence recognition.
Quarterly reviews of biophysics 2005;38(4):311-20.
2005: Jonathan P May; Lynda J Brown; Ian van Delft; Nicola Thelwell; Kate Harley; Tom Brown
Synthesis and evaluation of a new non-fluorescent quencher in fluorogenic oligonucleotide probes for real-time PCR.
Organic & biomolecular chemistry 2005;3(14):2534-42.
2005: L Dyadyusha; H Yin; S Jaiswal; Tom Brown; Jeremy J Baumberg; frank booy; Tracy Melvin
Quenching of CdSe quantum dot emission, a new approach for biosensing.
Chemical communications (Cambridge, England) 2005;(25):3201-3.
2005: Rohan T Ranasinghe; David A Rusling; Vicki E C Powers; Keith R Fox; Tom Brown
Recognition of CG inversions in DNA triple helices by methylated 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues.
Chemical communications (Cambridge, England) 2005;(20):2555-7.
2005: Yang Wang; David A Rusling; Vicki E C Powers; Oliver Lack; Sadie D Osborne; Keith R Fox; Tom Brown
Stable recognition of TA interruptions by triplex forming oligonucleotides containing a novel nucleoside.
Biochemistry 2005;44(15):5884-92.
2005: James Booth; Tom Brown; Sunil J Vadhia; Oliver Lack; W Jon Cummins; John O Trent; Andrew N Lane
Determining the origin of the stabilization of DNA by 5-aminopropynylation of pyrimidines.
Biochemistry 2005;44(12):4710-9.
2005: Peter Sandin; L Marcus Wilhelmsson; Per Lincoln; Vicki E C Powers; Tom Brown; Bo Albinsson
Fluorescent properties of DNA base analogue tC upon incorporation into DNA--negligible influence of neighbouring bases on fluorescence quantum yield.
Nucleic acids research 2005;33(16):5019-25.
2005: David A Rusling; Vicki E C Powers; Rohan T Ranasinghe; Yang Wang; Sadie D Osborne; Tom Brown; Keith R Fox
Four base recognition by triplex-forming oligonucleotides at physiological pH.
Nucleic acids research 2005;33(9):3025-32.
2004: Peter L James; Loic Le Strat; Ulf Ellervik; Christina Bratwall; Bengt Nordén; Tom Brown; Keith R Fox
Effects of a hairpin polyamide on DNA melting: comparison with distamycin and Hoechst 33258.
Biophysical chemistry 2004;111(3):205-12.
2004: James Booth; W Jon Cummins; Tom Brown
An analogue of adenine that forms an "A:T" base pair of comparable stability to G:C.
Chemical communications (Cambridge, England) 2004;(19):2208-9.
2004: K Cecilia Engman; Peter Sandin; Sadie Osborne; Tom Brown; Martin Billeter; Per Lincoln; Bengt Nordén; Bo Albinsson; L Marcus Wilhelmsson
DNA adopts normal B-form upon incorporation of highly fluorescent DNA base analogue tC: NMR structure and UV-Vis spectroscopy characterization.
Nucleic acids research 2004;32(17):5087-95.
2004: Sadie D Osborne; Vicki E C Powers; David A Rusling; Oliver Lack; Keith R Fox; Tom Brown
Selectivity and affinity of triplex-forming oligonucleotides containing 2'-aminoethoxy-5-(3-aminoprop-1-ynyl)uridine for recognizing AT base pairs in duplex DNA.
Nucleic acids research 2004;32(15):4439-47.
2004: H B Yin; Tom Brown; James S Wilkinson; Robert W Eason; Tracy Melvin
Submicron patterning of DNA oligonucleotides on silicon.
Nucleic acids research 2004;32(14):e118.
2004: Peter L James; Elena E Merkina; Abedawn I Khalaf; Colin J Suckling; Roger D Waigh; Tom Brown; Keith R Fox
DNA sequence recognition by an isopropyl substituted thiazole polyamide.
Nucleic acids research 2004;32(11):3410-7.
2003: Melanie D Keppler; Peter L James; Stephen Neidle; Tom Brown; Keith R Fox
DNA sequence specificity of triplex-binding ligands.
European journal of biochemistry / FEBS 2003;270(24):4982-92.
2003: Peter L James; Tom Brown; Keith R Fox
Thermodynamic and kinetic stability of intermolecular triple helices containing different proportions of C+*GC and T*AT triplets.
Nucleic acids research 2003;31(19):5598-606.
2003: Catherine M McKeen; Lynda J Brown; Jamie T G Nicol; John M Mellor; Tom Brown
Synthesis of fluorophore and quencher monomers for use in scorpion primers and nucleic acid structural probes.
Organic & biomolecular chemistry 2003;1(13):2267-75.
2003: Neil Dobson; David G McDowell; David J French; Lynda J Brown; John M Mellor; Tom Brown
Synthesis of HyBeacons and dual-labelled probes containing 2'-fluorescent groups for use in genetic analysis.
Chemical communications (Cambridge, England) 2003;(11):1234-5.
2003: Jeffrey I Gyi; Daquan Gao; Graeme L Conn; John O Trent; Tom Brown; Andrew N Lane
The solution structure of a DNA*RNA duplex containing 5-propynyl U and C; comparison with 5-Me modifications.
Nucleic acids research 2003;31(10):2683-93.
2003: James Brown; Tom Brown; Keith R Fox
Cleavage of fragments containing DNA mismatches by enzymic and chemical probes.
The Biochemical journal 2003;371(Pt 3):697-708.
2003: Jonathan P May; Lynda J Brown; Ivo Rudloff; Tom Brown
A new dark quencher for use in genetic analysis.
Chemical communications (Cambridge, England) 2003;(8):970-1.
2002: Antonio Solinas; Nicola Thelwell; Tom Brown
Intramolecular TaqMan probes for genetic analysis.
Chemical communications (Cambridge, England) 2002;(19):2272-3.
2002: Matthieu Sollogoub; Richard A J Darby; Bernard Cuenoud; Tom Brown; Keith R Fox
Stable DNA triple helix formation using oligonucleotides containing 2'-aminoethoxy,5-propargylamino-U.
Biochemistry 2002;41(23):7224-31.
2002: Richard A J Darby; Matthieu Sollogoub; Catherine M McKeen; Lynda Brown; Antonina Risitano; Nicholas Brown; Christopher Barton; Tom Brown; Keith R Fox
High throughput measurement of duplex, triplex and quadruplex melting curves using molecular beacons and a LightCycler.
Nucleic acids research 2002;30(9):e39.
2001: Antonio Solinas; Lynda J Brown; Catherine M McKeen; John M Mellor; J Nicol; Nicola Thelwell; Tom Brown
Duplex Scorpion primers in SNP analysis and FRET applications.
Nucleic acids research 2001;29(20):E96.
2001: Tom Brown; K Mackey
Analysis of RNA by northern and slot-blot hybridization.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] 2001;Chapter 5():Unit 5.17.
2001: Tom Brown
Hybridization analysis of DNA blots.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001;Chapter 10():Unit 10.6B.
2001: Tom Brown
Southern blotting.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001;Chapter 10():Unit 10.6A.
2001: Tom Brown
Analysis of RNA by northern and slot-blot hybridization.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001;Chapter 10():Unit 10.12.
2001: Tom Brown; K Struhl
Hybridization analysis of DNA blots.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2001;Appendix 4():Appendix 4H.
2001: Tom Brown
Southern blotting.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2001;Appendix 4():Appendix 4G.
2001: J Brown; Tom Brown; Keith R Fox
Affinity of mismatch-binding protein MutS for heteroduplexes containing different mismatches.
The Biochemical journal 2001;354(Pt 3):627-33.
2000: Nicola Thelwell; S Millington; Antonio Solinas; J Booth; Tom Brown
Mode of action and application of Scorpion primers to mutation detection.
Nucleic acids research 2000;28(19):3752-61.
2000: Keith R Fox; S L Allinson; H Sahagun-Krause; Tom Brown
Recognition of GT mismatches by Vsr mismatch endonuclease.
Nucleic acids research 2000;28(13):2535-40.
1999: Melanie D Keppler; Catherine M McKeen; Oliwia Zegrocka; Lucjan Strekowski; Tom Brown; Keith R Fox
DNA triple helix stabilisation by covalent attachment of a triplex-specific ligand.
Biochimica et biophysica acta 1999;1447(2-3):137-45.
1999: DM Gowers; J Bijapur; Tom Brown; Keith R Fox
DNA triple helix formation at target sites containing several pyrimidine interruptions: stabilization by protonated cytosine or 5-(1-propargylamino)dU.
Biochemistry 1999;38(41):13747-58.
1999: J Bijapur; Melanie D Keppler; S Bergqvist; Tom Brown; Keith R Fox
5-(1-propargylamino)-2'-deoxyuridine (UP): a novel thymidine analogue for generating DNA triplexes with increased stability.
Nucleic acids research 1999;27(8):1802-9.
1999: JL Asensio; Tom Brown; Andrew N Lane
Solution conformation of a parallel DNA triple helix with 5' and 3' triplex-duplex junctions.
Structure (London, England : 1993) 1999;7(1):1-11.
1999: G L Conn; Tom Brown; G A Leonard
The crystal structure of the RNA/DNA hybrid r(GAAGAGAAGC). d(GCTTCTCTTC) shows significant differences to that found in solution.
Nucleic acids research 1999;27(2):555-61.
1999: G John Langley; Julie M Herniman; N L Davies; Tom Brown
Simplified sample preparation for the analysis of oligonucleotides by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry.
Rapid communications in mass spectrometry : RCM 1999;13(17):1717-23.
1998: JL Asensio; Tom Brown; Andrew N Lane
Comparison of the solution structures of intramolecular DNA triple helices containing adjacent and non-adjacent CG.C+ triplets.
Nucleic acids research 1998;26(16):3677-86.
1998: Jeffrey I Gyi; Andrew N Lane; Graeme L Conn; Tom Brown
The orientation and dynamics of the C2'-OH and hydration of RNA and DNA.RNA hybrids.
Nucleic acids research 1998;26(13):3104-10.
1998: JL Asensio; Andrew N Lane; J Dhesi; S Bergqvist; Tom Brown
The contribution of cytosine protonation to the stability of parallel DNA triple helices.
Journal of molecular biology 1998;275(5):811-22.
1998: Jeffrey I Gyi; Andrew N Lane; Graeme L Conn; Tom Brown
Solution structures of DNA.RNA hybrids with purine-rich and pyrimidine-rich strands: comparison with the homologous DNA and RNA duplexes.
Biochemistry 1998;37(1):73-80.
1997: G F Bonifacio; Tom Brown; Graeme L Conn; Andrew N Lane
Comparison of the electrophoretic and hydrodynamic properties of DNA and RNA oligonucleotide duplexes.
Biophysical journal 1997;73(3):1532-8.
1997: M R Conte; Graeme L Conn; Tom Brown; Andrew N Lane
Conformational properties and thermodynamics of the RNA duplex r(CGCAAAUUUGCG)2: comparison with the DNA analogue d(CGCAAATTTGCG)2.
Nucleic acids research 1997;25(13):2627-34.
1997: A A Moraru-Allen; S Cassidy; J L Asensio Alvarez; K R Fox; Tom Brown; Andrew N Lane
Coralyne has a preference for intercalation between TA.T triples in intramolecular DNA triple helices.
Nucleic acids research 1997;25(10):1890-6.
1997: D H Sutton; Graeme L Conn; Tom Brown; Andrew N Lane
The dependence of DNase I activity on the conformation of oligodeoxynucleotides.
The Biochemical journal 1997;321 ( Pt 2)():481-6.
1996: M R Conte; Graeme L Conn; Tom Brown; Andrew N Lane
Hydration of the RNA duplex r(CGCAAAUUUGCG)2 determined by NMR.
Nucleic acids research 1996;24(19):3693-9.
1996: J I Gyi; Graeme L Conn; Andrew N Lane; Tom Brown
Comparison of the thermodynamic stabilities and solution conformations of DNA.RNA hybrids containing purine-rich and pyrimidine-rich strands with DNA and RNA duplexes.
Biochemistry 1996;35(38):12538-48.
1996: P J Finn; N J Gibson; R Fallon; A Hamilton; Tom Brown
Synthesis and properties of DNA-PNA chimeric oligomers.
Nucleic acids research 1996;24(17):3357-63.
1996: Titus Boggon; E L Hancox; K E McAuley-Hecht; B A Connolly; William N Hunter; Tom Brown; RT Walker; G A Leonard
The crystal structure analysis of d(CGCGAASSCGCG)2, a synthetic DNA dodecamer duplex containing four 4'-thio-2'-deoxythymidine nucleotides.
Nucleic acids research 1996;24(5):951-61.
1995: Alain Dautant; Béatrice Langlois d'Estaintot; Bernard Gallois; Tom Brown; William N Hunter
A trigonal form of the idarubicin:d(CGATCG) complex; crystal and molecular structure at 2.0 A resolution.
Nucleic acids research 1995;23(10):1710-6.
1995: G A Leonard; S Zhang; M R Peterson; S J Harrop; John R Helliwell; W B Cruse; B L d'Estaintot; O Kennard; Tom Brown; William N Hunter
Self-association of a DNA loop creates a quadruplex: crystal structure of d(GCATGCT) at 1.8 A resolution.
Structure (London, England : 1993) 1995;3(4):335-40.
1995: A Chen; Lynn M Powell; David T F Dryden; Noreen E Murray; Tom Brown
Tyrosine 27 of the specificity polypeptide of EcoKI can be UV crosslinked to a bromodeoxyuridine-substituted DNA target sequence.
Nucleic acids research 1995;23(7):1177-83.
1995: G A Leonard; K McAuley-Hecht; Tom Brown; William N Hunter
Do C-H...O hydrogen bonds contribute to the stability of nucleic acid base pairs?
Acta crystallographica. Section D, Biological crystallography 1995;51(Pt 2):136-9.
1994: K E McAuley-Hecht; G A Leonard; N J Gibson; J B Thomson; W P Watson; William N Hunter; Tom Brown
Crystal structure of a DNA duplex containing 8-hydroxydeoxyguanine-adenine base pairs.
Biochemistry 1994;33(34):10266-70.
1994: G A Leonard; K E McAuley-Hecht; S Ebel; D M Lough; Tom Brown; William N Hunter
Crystal and molecular structure of r(CGCGAAUUAGCG): an RNA duplex containing two G(anti).A(anti) base pairs.
Structure (London, England : 1993) 1994;2(6):483-94.
1994: G A Leonard; K E McAuley-Hecht; N J Gibson; Tom Brown; W P Watson; William N Hunter
Guanine-1,N6-ethenoadenine base pairs in the crystal structure of d(CGCGAATT(epsilon dA)GCG).
Biochemistry 1994;33(16):4755-61.
1994: A Lane; S y Ebel; Tom Brown
Properties of multiple G.A mismatches in stable oligonucleotide duplexes.
European journal of biochemistry / FEBS 1994;220(3):717-27.
1994: S Ebel; Tom Brown; Andrew N Lane
Thermodynamic stability and solution conformation of tandem G.A mismatches in RNA and RNA.DNA hybrid duplexes.
European journal of biochemistry / FEBS 1994;220(3):703-15.
1993: S Teigelkamp; S Ebel; D W Will; Tom Brown; Jean D Beggs
Branched poly-labelled oligonucleotides: enhanced specificity of fork-shaped biotinylated oligoribonucleotides for antisense affinity selection.
Nucleic acids research 1993;21(19):4651-2.
1993: G A Leonard; T W Hambley; K McAuley-Hecht; Tom Brown; William N Hunter
Anthracycline-DNA interactions at unfavourable base-pair triplet-binding sites: structures of d(CGGCCG)/daunomycin and d(TGGCCA)/adriamycin complexes.
Acta crystallographica. Section D, Biological crystallography 1993;49(Pt 5):458-67.
1993: Andrew N Lane; S Ebel; Tom Brown
NMR assignments and solution conformation of the DNA.RNA hybrid duplex d(GTGAACTT).r(AAGUUCAC).
European journal of biochemistry / FEBS 1993;215(2):297-306.
1993: Bernard Gallois; B L d'Estaintot; Tom Brown; William N Hunter
The structure of an idarubicin-d(TGATCA) complex at high resolution.
Acta crystallographica. Section D, Biological crystallography 1993;49(Pt 3):311-7.
1993: J Grzybowski; D W Will; R E Randall; C A Smith; Tom Brown
Synthesis and antibody-mediated detection of oligonucleotides containing multiple 2,4-dinitrophenyl reporter groups.
Nucleic acids research 1993;21(8):1705-12.
1993: A Lane; Stephen Martin; S Ebel; Tom Brown
Solution conformation of a deoxynucleotide containing tandem G.A mismatched base pairs and 3'-overhanging ends in d(GTGAACTT)2.
Biochemistry 1993;32(14):3829.
1992: S Ebel; Andrew N Lane; Tom Brown
Very stable mismatch duplexes: structural and thermodynamic studies on tandem G.A mismatches in DNA.
Biochemistry 1992;31(48):12083-6.
1992: A Lane; Stephen Martin; S Ebel; Tom Brown
Solution conformation of a deoxynucleotide containing tandem G.A mismatched base pairs and 3'-overhanging ends in d(GTGAACTT)2.
Biochemistry 1992;31(48):12087-95.
1992: G A Leonard; E D Booth; William N Hunter; Tom Brown
The conformational variability of an adenosine.inosine base-pair in a synthetic DNA dodecamer.
Nucleic acids research 1992;20(18):4753-9.
1992: G A Leonard; A Guy; Tom Brown; R Téoule; William N Hunter
Conformation of guanine-8-oxoadenine base pairs in the crystal structure of d(CGCGAATT(O8A)GCG).
Biochemistry 1992;31(36):8415-20.
1992: Béatrice Langlois d'Estaintot; Bernard Gallois; Tom Brown; William N Hunter
The molecular structure of a 4'-epiadriamycin complex with d(TGATCA) at 1.7A resolution: comparison with the structure of 4'-epiadriamycin d(TGTACA) and d(CGATCG) complexes.
Nucleic acids research 1992;20(14):3561-6.
1992: C MacKellar; D Graham; D W Will; S Burgess; Tom Brown
Synthesis and physical properties of anti-HIV antisense oligonucleotides bearing terminal lipophilic groups.
Nucleic acids research 1992;20(13):3411-7.
1992: Katherine L B Borden; T C Jenkins; J V Skelly; Tom Brown; Andrew N Lane
Conformational properties of the G.G mismatch in d(CGCGAATTGGCG)2 determined by NMR.
Biochemistry 1992;31(23):5411-22.
1992: G A Leonard; Tom Brown; William N Hunter
Anthracycline binding to DNA. High-resolution structure of d(TGTACA) complexed with 4'-epiadriamycin.
European journal of biochemistry / FEBS 1992;204(1):69-74.
1991: Andrew N Lane; T C Jenkins; D J Brown; Tom Brown
N.m.r. determination of the solution conformation and dynamics of the A.G mismatch in the d(CGCAAATTGGCG)2 dodecamer.
The Biochemical journal 1991;279 ( Pt 1)():269-81.
1991: D W Will; C E Pritchard; Tom Brown
The synthesis of oligonucleotides that contain 2,4-dinitrophenyl reporter groups.
Carbohydrate research 1991;216():315-22.
1991: Andrew N Lane; T C Jenkins; Tom Brown; S Neidle
Interaction of berenil with the EcoRI dodecamer d(CGCGAATTCGCG)2 in solution studied by NMR.
Biochemistry 1991;30(5):1372-85.
1990: G A Leonard; J Thomson; W P Watson; Tom Brown
High-resolution structure of a mutagenic lesion in DNA.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9573-6.
1990: G A Leonard; E D Booth; Tom Brown
Structural and thermodynamic studies on the adenine.guanine mismatch in B-DNA.
Nucleic acids research 1990;18(19):5617-23.
1990: Tom Brown; G A Leonard; E D Booth; G Kneale
Influence of pH on the conformation and stability of mismatch base-pairs in DNA.
Journal of molecular biology 1990;212(3):437-40.
1989: Tom Brown; G A Leonard; E D Booth; J Chambers
Crystal structure and stability of a DNA duplex containing A(anti).G(syn) base-pairs.
Journal of molecular biology 1989;207(2):455-7.
1989: W B Cruse; J Aymani; O Kennard; Tom Brown; A G Jack; G A Leonard
Refined crystal structure of an octanucleotide duplex with I.T. mismatched base pairs.
Nucleic acids research 1989;17(1):55-72.
1987: P W Corfield; William N Hunter; Tom Brown; P Robinson; O Kennard
Inosine.adenine base pairs in a B-DNA duplex.
Nucleic acids research 1987;15(19):7935-49.
1986: W B Cruse; S A Salisbury; Tom Brown; R Cosstick; F Eckstein; O Kennard
Chiral phosphorothioate analogues of B-DNA. The crystal structure of Rp-d[Gp(S)CpGp(S)CpGp(S)C].
Journal of molecular biology 1986;192(4):891-905.