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Hemachandra Reddy

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TOP 3
P Hemachandra Reddy
Is the mitochondrial outermembrane protein VDAC1 therapeutic target for Alzheimer's disease?
Maria Manczak; P Hemachandra Reddy
Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease.
Peizhong Mao; Peter S Rabinovitch; Arubala P Reddy; Marcus J Calkins; Herng-Hsiang Lo; Maria Manczak; Tejaswini P Reddy; Ulziibat Shirendeb; Quang Truong; P Hemachandra Reddy
Mitochondria-targeted catalase reduces abnormal APP processing, amyloid β production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension.

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All Publications

2013: P Hemachandra Reddy
Is the mitochondrial outermembrane protein VDAC1 therapeutic target for Alzheimer's disease?
Biochimica et biophysica acta 2013;1832(1):67-75.
2012: Maria Manczak; P Hemachandra Reddy
Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease.
Human molecular genetics 2012;21(23):5131-46.
2012: Peizhong Mao; Peter S Rabinovitch; Arubala P Reddy; Marcus J Calkins; Herng-Hsiang Lo; Maria Manczak; Tejaswini P Reddy; Ulziibat Shirendeb; Quang Truong; P Hemachandra Reddy
Mitochondria-targeted catalase reduces abnormal APP processing, amyloid β production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension.
Human molecular genetics 2012;21(13):2973-90.
2012: Maria Manczak; Yusuke Kageyama; Hiromi Sesaki; P Hemachandra Reddy
Dynamin-related protein 1 heterozygote knockout mice do not have synaptic and mitochondrial deficiencies.
Biochimica et biophysica acta 2012;1822(6):862-74.
2012: Maria Manczak; P Hemachandra Reddy
Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage.
Human molecular genetics 2012;21(11):2538-47.
2012: Yusuke Kageyama; Thomas W Kensler; P Hemachandra Reddy; Ricardo Roda; MASAHIRO FUKAYA; Miho Iijima; Junko Wakabayashi; Nobunao Wakabayashi; Zhongyan Zhang; Hiromi Sesaki
Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage.
The Journal of cell biology 2012;197(4):535-51.
2012: P Hemachandra Reddy; Tejaswini P Reddy; Ulziibat P Shirendeb; Karuna Tirumala; Raghav Tripathi; Quang Troung; Vishwanath Anekonda; Marcus J Calkins; Peizhong Mao; Arubala P Reddy; Maria Manczak
Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: implications to mitochondria-targeted antioxidant therapeutics.
Biochimica et biophysica acta 2012;1822(5):639-49.
2012: P Hemachandra Reddy
Editorial of a special issue. Current status of therapeutics and preventive measures for patients with thalassaemia and sickle cell disease.
Cardiovascular & hematological agents in medicinal chemistry 2012;10(1):2.
2011: Marcus J Calkins; Maria Manczak; Peizhong Mao; Ulziibat Shirendeb; P Hemachandra Reddy
Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease.
Human molecular genetics 2011;20(23):4515-29.
2011: Peizhong Mao; P Hemachandra Reddy
Aging and amyloid beta-induced oxidative DNA damage and mitochondrial dysfunction in Alzheimer's disease: implications for early intervention and therapeutics.
Biochimica et biophysica acta 2011;1812(11):1359-70.
2011: P Hemachandra Reddy
Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease.
Brain research 2011;1415():136-48.
2011: Marcus J Calkins; P Hemachandra Reddy
Assessment of newly synthesized mitochondrial DNA using BrdU labeling in primary neurons from Alzheimer's disease mice: Implications for impaired mitochondrial biogenesis and synaptic damage.
Biochimica et biophysica acta 2011;1812(9):1182-9.
2011: Ulises M Ricoy; Maria Manczak; Peizhong Mao; P Hemachandra Reddy; Matthew E Frerking
A transgenic mouse model for Alzheimer's disease has impaired synaptic gain but normal synaptic dynamics.
Neuroscience letters 2011;500(3):212-5.
2011: Maria Manczak; Marcus J Calkins; P Hemachandra Reddy
Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage.
Human molecular genetics 2011;20(13):2495-509.
2011: P Hemachandra Reddy; Tejaswini P Reddy; Maria Manczak; Marcus J Calkins; Ulziibat Shirendeb; Peizhong Mao
Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases.
Brain research reviews 2011;67(1-2):103-18.
2011: P Hemachandra Reddy; T P Reddy
Mitochondria as a therapeutic target for aging and neurodegenerative diseases.
Current Alzheimer research 2011;8(4):393-409.
2011: Marcus J Calkins; P Hemachandra Reddy
Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons.
Biochimica et biophysica acta 2011;1812(4):507-13.
2011: Tejaswini P Reddy; Maria Manczak; Marcus J Calkins; Peizhong Mao; Arubala P Reddy; Ulziibat Shirendeb; Byung Park; P Hemachandra Reddy
Toxicity of neurons treated with herbicides and neuroprotection by mitochondria-targeted antioxidant SS31.
International journal of environmental research and public health 2011;8(1):203-21.
2010: Maria Manczak; Peizhong Mao; Marcus J Calkins; Anda Cornea; Arubala P Reddy; Michael P Murphy; Hazel H Szeto; Byung S Park; P Hemachandra Reddy
Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons.
Journal of Alzheimer's disease : JAD 2010;20 Suppl 2():S609-31.
2010: P Hemachandra Reddy; Maria Manczak; Peizhong Mao; Marcus J Calkins; Arubala P Reddy; Ulziibat Shirendeb
Amyloid-beta and mitochondria in aging and Alzheimer's disease: implications for synaptic damage and cognitive decline.
Journal of Alzheimer's disease : JAD 2010;20 Suppl 2():S499-512.
2010: Peizhong Mao; P Hemachandra Reddy
Is multiple sclerosis a mitochondrial disease?
Biochimica et biophysica acta 2010;1802(1):66-79.
2009: P Hemachandra Reddy; Maria Manczak; Wei Zhao; Kazuhiro Nakamura; Christopher Bebbington; Geoffrey Yarranton; Peizhong Mao
Granulocyte-macrophage colony-stimulating factor antibody suppresses microglial activity: implications for anti-inflammatory effects in Alzheimer's disease and multiple sclerosis.
Journal of neurochemistry 2009;111(6):1514-28.
2009: Maria Manczak; Peizhong Mao; Kazuhiro Nakamura; Christopher Bebbington; Byung S Park; P Hemachandra Reddy
Neutralization of granulocyte macrophage colony-stimulating factor decreases amyloid beta 1-42 and suppresses microglial activity in a transgenic mouse model of Alzheimer's disease.
Human molecular genetics 2009;18(20):3876-93.
2009: P Hemachandra Reddy
Role of mitochondria in neurodegenerative diseases: mitochondria as a therapeutic target in Alzheimer's disease.
CNS spectrums 2009;14(8 Suppl 7):8-13; discussion 16-8.
2009: P Hemachandra Reddy
Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease.
Experimental neurology 2009;218(2):286-92.
2009: P Hemachandra Reddy; Peizhong Mao; Maria Manczak
Mitochondrial structural and functional dynamics in Huntington's disease.
Brain research reviews 2009;61(1):33-48.
2008: P Hemachandra Reddy; M Flint Beal
Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease.
Trends in molecular medicine 2008;14(2):45-53.
2008: P Hemachandra Reddy
Mitochondrial medicine for aging and neurodegenerative diseases.
Neuromolecular medicine 2008;10(4):291-315.
2007: P Hemachandra Reddy
Mitochondrial dysfunction in aging and Alzheimer's disease: strategies to protect neurons.
Antioxidants & redox signaling 2007;9(10):1647-58.
2006: M Flint Beal; Ella Bossy-Wetzel; Steven Finkbeiner; Gary Fiskum; Benoit Giasson; Carl Johnson; ZAVEN KHACHATURIAN; Virginia M-Y Lee; David Nicholls; P Hemachandra Reddy; Ian Reynolds; David B Teplow; Leon J Thal; John Q Trojanowski; Dominic M Walsh; Ronald B. Wetzel; Nancy S Wexler; Anne B Young; Lisa Bain
Common threads in neurodegenerative disorders of aging.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2006;2(4):322-6.
2006: P Hemachandra Reddy; Shannon McWeeney
Mapping cellular transcriptosomes in autopsied Alzheimer's disease subjects and relevant animal models.
Neurobiology of aging 2006;27(8):1060-77.
2006: Maria Manczak; Thimmappa S Anekonda; Edward Henson; Byung S Park; Joseph F Quinn; P Hemachandra Reddy
Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression.
Human molecular genetics 2006;15(9):1437-49.
2006: P Hemachandra Reddy
Mitochondrial oxidative damage in aging and Alzheimer's disease: implications for mitochondrially targeted antioxidant therapeutics.
Journal of biomedicine & biotechnology 2006;2006(3):31372.
2006: P Hemachandra Reddy
Amyloid precursor protein-mediated free radicals and oxidative damage: implications for the development and progression of Alzheimer's disease.
Journal of neurochemistry 2006;96(1):1-13.
2006: Thimmappa S Anekonda; P Hemachandra Reddy
Neuronal protection by sirtuins in Alzheimer's disease.
Journal of neurochemistry 2006;96(2):305-13.
2005: Thimmappa S Anekonda; P Hemachandra Reddy
Can herbs provide a new generation of drugs for treating Alzheimer's disease?
Brain research. Brain research reviews 2005;50(2):361-76.
2005: P Hemachandra Reddy; M Flint Beal
Are mitochondria critical in the pathogenesis of Alzheimer's disease?
Brain research. Brain research reviews 2005;49(3):618-32.
2005: P Hemachandra Reddy; Geethalakshmi Mani; Byung S Park; Joline Jacques; Geoffrey Murdoch; William O Whetsell; Jeffrey A Kaye; Maria Manczak
Differential loss of synaptic proteins in Alzheimer's disease: implications for synaptic dysfunction.
Journal of Alzheimer's disease : JAD 2005;7(2):103-17; discussion 173-80.
2005: Maria Manczak; Youngsin Jung; Byung S Park; Dara Partovi; P Hemachandra Reddy
Time-course of mitochondrial gene expressions in mice brains: implications for mitochondrial dysfunction, oxidative damage, and cytochrome c in aging.
Journal of neurochemistry 2005;92(3):494-504.
2005: Jonathan A Sayer; Maria Manczak; Lakshmi Akileswaran; P Hemachandra Reddy; Vincent M Coghlan
Interaction of the nuclear matrix protein NAKAP with HypA and huntingtin: implications for nuclear toxicity in Huntington's disease pathogenesis.
Neuromolecular medicine 2005;7(4):297-310.
2004: P Hemachandra Reddy; Shannon McWeeney; Byung S Park; Maria Manczak; Ramana V Gutala; Dara Partovi; Youngsin Jung; Vincent Yau; Robert Searles; Motomi Mori; Joseph F Quinn
Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease.
Human molecular genetics 2004;13(12):1225-40.
2004: Ramana V Gutala; P Hemachandra Reddy
The use of real-time PCR analysis in a gene expression study of Alzheimer's disease post-mortem brains.
Journal of neuroscience methods 2004;132(1):101-7.
2004: Maria Manczak; Byung S Park; Youngsin Jung; P Hemachandra Reddy
Differential expression of oxidative phosphorylation genes in patients with Alzheimer's disease: implications for early mitochondrial dysfunction and oxidative damage.
Neuromolecular medicine 2004;5(2):147-62.
2003: Vladimir V Senatorov; Vinod Charles; P Hemachandra Reddy; Danilo A Tagle; De-Maw Chuang
Overexpression and nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase in a transgenic mouse model of Huntington's disease.
Molecular and cellular neurosciences 2003;22(3):285-97.
2001: Genevieve Laforet; Ellen Sapp; Kathryn O Chase; C McIntyre; F M Boyce; M Campbell; B A Cadigan; L Warzecki; Danilo A Tagle; P Hemachandra Reddy; Carlos Cepeda; Christopher R Calvert; Eve S Jokel; Gloria J Klapstein; Marjorie A Ariano; Michael S Levine; Marian DiFiglia; Neil Aronin
Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(23):9112-23.
2001: Y Sun; A Savanenin; P Hemachandra Reddy; YF Liu
Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95.
The Journal of biological chemistry 2001;276(27):24713-8.
2001: Paolo Guidetti; Vinod Charles; Er-Yun Chen; P Hemachandra Reddy; Jeffrey Kordower; William O Whetsell; Robert Schwarcz; Danilo A Tagle
Early degenerative changes in transgenic mice expressing mutant huntingtin involve dendritic abnormalities but no impairment of mitochondrial energy production.
Experimental neurology 2001;169(2):340-50.
2000: Vinod Charles; Eva Mezey; P Hemachandra Reddy; AM Dehejia; Theresa A Young; Mihael H Polymeropoulos; MJ Brownstein; Danilo A Tagle
Alpha-synuclein immunoreactivity of huntingtin polyglutamine aggregates in striatum and cortex of Huntington's disease patients and transgenic mouse models.
Neuroscience letters 2000;289(1):29-32.
2000: Sarabjit Mastana; P Hemachandra Reddy; M K Das; P Reddy; K Das
Molecular genetic diversity in 5 populations of Madhya Pradesh, India.
Human biology 2000;72(3):499-510.
2000: Paolo Guidetti; P Hemachandra Reddy; Danilo A Tagle; Robert Schwarcz
Early kynurenergic impairment in Huntington's disease and in a transgenic animal model.
Neuroscience letters 2000;283(3):233-5.
1999: P Hemachandra Reddy; Vinod Charles; M Williams; G Miller; William O Whetsell; Danilo A Tagle
Transgenic mice expressing mutated full-length HD cDNA: a paradigm for locomotor changes and selective neuronal loss in Huntington's disease.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1999;354(1386):1035-45.
1999: P Hemachandra Reddy; M Williams; Danilo A Tagle
Recent advances in understanding the pathogenesis of Huntington's disease.
Trends in neurosciences 1999;22(6):248-55.
1999: M Kim; H S Lee; Genevieve Laforet; C McIntyre; E J Martin; P Chang; TW Kim; M Williams; P Hemachandra Reddy; Danilo A Tagle; F M Boyce; L Won; A Heller; Neil Aronin; Marian DiFiglia
Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(3):964-73.
1998: P Hemachandra Reddy; M Williams; Vinod Charles; L Garrett; L Pike-Buchanan; William O Whetsell; G Miller; Danilo A Tagle
Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA.
Nature genetics 1998;20(2):198-202.
1998: Sarabjit Mastana; R Calderon; J Pena; P Hemachandra Reddy; Surinder S Papiha
Anthropology of the apoplipoprotein E (apo E) gene: low frequency of apo E4 allele in Basques and in tribal (Baiga) populations of India.
Annals of human biology 1998;25(2):137-43.
1997: P Hemachandra Reddy; E Stockburger; P Gillevet; Danilo A Tagle
Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method.
Genomics 1997;46(2):174-82.
1997: P Hemachandra Reddy; Bernadette Modell
The Baigas of Madhya Pradesh: a demographic study.
Journal of biosocial science 1997;29(1):19-31.
1996: P Hemachandra Reddy; Bernadette Modell
Reproductive behaviour and natural selection for the sickle gene in the Baiga tribe of central India: the role of social parenting.
Annals of human genetics 1996;60(Pt 3):231-6.
1995: Jaspal Kaeda; G P Chhotray; M R Ranjit; José M Bautista; P Hemachandra Reddy; D Stevens; J M Naidu; R P Britt; Tom Vulliamy; Lucio Luzzatto
A new glucose-6-phosphate dehydrogenase variant, G6PD Orissa (44 Ala-->Gly), is the major polymorphic variant in tribal populations in India.
American journal of human genetics 1995;57(6):1335-41.
1995: P Hemachandra Reddy; Richard S Tedder
Hepatitis virus markers in the Baiga tribal population of Madhya Pradesh, India.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1995;89(6):620.
1995: P Hemachandra Reddy; Mary Petrou; P A Reddy; R S Tiwary; Bernadette Modell
Hereditary anaemias and iron deficiency in a tribal population (the Baiga) of central India.
European journal of haematology 1995;55(2):103-9.
1995: P Hemachandra Reddy; Bernadette Modell
Consanguinity and reproductive behaviour in a tribal population 'the Baiga' in Madhya Pradesh, India.
Annals of human biology 1995;22(3):235-46.
1995: P Hemachandra Reddy; Sarabjit Mastana
Genetic variation of serum proteins (GC, TF and PI subtypes) in the Baigas of Madhya Pradesh, India.
Anthropologischer Anzeiger; Bericht über die biologisch-anthropologische Literatur 1995;53(1):53-6.