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David Hein

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Lori M Millner; J.Christopher States; Jian Cai; Mark A Doll; David W Hein
NATb/NAT1*4 promotes greater arylamine N-acetyltransferase 1 mediated DNA adducts and mutations than NATa/NAT1*4 following exposure to 4-aminobiphenyl.
Lori M Millner; J.Christopher States; Marcus W Stepp; Mark A Doll; David W Hein
Functional analysis of arylamine N-acetyltransferase 1 (NAT1) NAT1*10 haplotypes in a complete NATb mRNA construct.
Nicole A Lavender; Jason H Moore; Erica N Rogers; James Rudd; Susan Yeyeodu; Jie Zhang; Guy N Brock; David W Hein; Ting Hu; Kevin S Kimbro; La Creis R Kidd
Interaction among apoptosis-associated sequence variants and joint effects on aggressive prostate cancer.

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2012: Lori M Millner; J.Christopher States; Jian Cai; Mark A Doll; David W Hein
NATb/NAT1*4 promotes greater arylamine N-acetyltransferase 1 mediated DNA adducts and mutations than NATa/NAT1*4 following exposure to 4-aminobiphenyl.
Molecular carcinogenesis 2012;51(8):636-46.
2012: Lori M Millner; J.Christopher States; Marcus W Stepp; Mark A Doll; David W Hein
Functional analysis of arylamine N-acetyltransferase 1 (NAT1) NAT1*10 haplotypes in a complete NATb mRNA construct.
Carcinogenesis 2012;33(2):348-55.
2012: Nicole A Lavender; Jason H Moore; Erica N Rogers; James Rudd; Susan Yeyeodu; Jie Zhang; Guy N Brock; David W Hein; Ting Hu; Kevin S Kimbro; La Creis R Kidd
Interaction among apoptosis-associated sequence variants and joint effects on aggressive prostate cancer.
BMC medical genomics 2012;5():11.
2012: Lisa F Potts; Rosa Rademakers; Shesh N Rai; Owen A Ross; Ryan J Uitti; Zbigniew K Wszolek; Alex C Cambon; Dennis W Dickson; Matthew J Farrer; David W Hein; Irene Litvan
Polymorphic genes of detoxification and mitochondrial enzymes and risk for progressive supranuclear palsy: a case control study.
BMC medical genetics 2012;13():16.
2011: Stella Koutros; Lee E Moore; Lindsay M Morton; Nathaniel Rothman; Alan R Schned; Molly Schwenn; Debra T Silverman; Shelia Hoar Zahm; Dalsu Baris; Sai Cherala; Joanne S Colt; Mark A Doll; David W Hein; Alison Johnson; Margaret R Karagas
Hair dye use and risk of bladder cancer in the New England bladder cancer study.
International journal of cancer. Journal international du cancer 2011;129(12):2894-904.
2011: Montserrat García-Closas; David W Hein; Debra Silverman; Núria Malats; Meredith Yeager; Kevin Jacobs; Mark A Doll; Jonine D Figueroa; Dalsu Baris; Molly Schwenn; Manolis Kogevinas; Alison Johnson; Nilanjan Chatterjee; Lee E Moore; Timothy Moeller; Francisco X Real; STEPHEN CHANOCK; Nathaniel Rothman
A single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European background.
Pharmacogenetics and genomics 2011;21(4):231-6.
2011: Lee E Moore; D R Baris; Jonine D Figueroa; Montserrat Garcia-Closas; Margaret R Karagas; Molly Schwenn; A T Johnson; Jay H Lubin; David W Hein; C L Dagnall; Joanne S Colt; M Kida; M A Jones; Alan R Schned; S S Cherala; STEPHEN CHANOCK; Kenneth P Cantor; Debra T Silverman; Nathaniel Rothman
GSTM1 null and NAT2 slow acetylation genotypes, smoking intensity and bladder cancer risk: results from the New England bladder cancer study and NAT2 meta-analysis.
Carcinogenesis 2011;32(2):182-9.
2011: LaCreis R Kidd; David W Hein; Karen Woodson; Philip R Taylor; Demetrius Albanes; Jarmo Virtamo; Joseph A Tangrea
Lack of association of the N-acetyltransferase NAT1*10 allele with prostate cancer incidence, grade, or stage among smokers in Finland.
Biochemical genetics 2011;49(1-2):73-82.
2010: Robert C G Martin; Yan Li; Qiahong Liu; David Barker; Mark A Doll; David W Hein
Manganese superoxide dismutase expression as a function of genotype and lung cancer pathology.
Cancer investigation 2010;28(8):813-9.
2010: Mark A Doll; Yu Zang; Timothy Moeller; David W Hein
Codominant expression of N-acetylation and O-acetylation activities catalyzed by N-acetyltransferase 2 in human hepatocytes.
The Journal of pharmacology and experimental therapeutics 2010;334(2):540-4.
2010: Kristin J Metry; Jason R Neale; Mark A Doll; Ashley L Howarth; J.Christopher States; W Glenn McGregor; William M Pierce; David W Hein
Effect of rapid human N-acetyltransferase 2 haplotype on DNA damage and mutagenesis induced by 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline (MeIQx).
Mutation research 2010;684(1-2):66-73.
2010: Ziad Kanaan; M Robert Eichenberger; Michael Young; Daniel Colliver; Nigel Crawford; Gary A Cobbs; David W Hein; Susan Galandiuk
An alternative cyclin-D1 splice site is not linked to inflammatory bowel disease-associated neoplasia.
The International journal of biological markers 2010;25(1):27-31.
2010: Briseis A Kilfoy; Tongzhang Zheng; Qing Lan; Xuesong Han; Theodore R Holford; David W Hein; Qin Qin; Brian P Leaderer; Lindsay M Morton; Meredith Yeager; Peter Boyle; Ping Zhao; STEPHEN CHANOCK; Nathaniel Rothman; Yawei Zhang
Genetic variation in N-acetyltransferases 1 and 2, cigarette smoking, and risk of non-Hodgkin lymphoma.
Cancer causes & control : CCC 2010;21(1):127-33.
2009: Jean Bendaly; Mark A Doll; Lori M Millner; Kristin J Metry; Ned B Smith; William M Pierce; David W Hein
Differences between human slow N-acetyltransferase 2 alleles in levels of 4-aminobiphenyl-induced DNA adducts and mutations.
Mutation research 2009;671(1-2):13-9.
2009: Kathy B Baumgartner; Thomas J Schlierf; Dongyan Yang; Mark A Doll; David W Hein
N-acetyltransferase 2 genotype modification of active cigarette smoking on breast cancer risk among hispanic and non-hispanic white women.
Toxicological sciences : an official journal of the Society of Toxicology 2009;112(1):211-20.
2009: Kristin J Metry; Jason R Neale; Jean Bendaly; Ned B Smith; William M Pierce; David W Hein
Effect of N-acetyltransferase 2 polymorphism on tumor target tissue DNA adduct levels in rapid and slow acetylator congenic rats administered 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine or 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(11):2123-6.
2009: J Bendaly; K J Metry; Mark A Doll; G Jiang; J C States; N B Smith; J R Neale; J L Holloman; William M Pierce; David W Hein
Role of human CYP1A1 and NAT2 in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mutagenicity and DNA adducts.
Xenobiotica; the fate of foreign compounds in biological systems 2009;39(5):399-406.
2009: David W Hein
N-acetyltransferase SNPs: emerging concepts serve as a paradigm for understanding complexities of personalized medicine.
Expert opinion on drug metabolism & toxicology 2009;5(4):353-66.
2009: Nicole A Lavender; Marnita L Benford; Tiva T VanCleave; Guy N Brock; Rick Kittles; Jason H Moore; David W Hein; La Creis R Kidd
Examination of polymorphic glutathione S-transferase (GST) genes, tobacco smoking and prostate cancer risk among men of African descent: a case-control study.
BMC cancer 2009;9():397.
2009: Robert C G Martin; Yan Li; Qiahong Liu; Neil S Jensen; David Barker; Mark A Doll; David W Hein
Manganese superoxide dismutase V16A single-nucleotide polymorphism in the mitochondrial targeting sequence is associated with reduced enzymatic activity in cryopreserved human hepatocytes.
DNA and cell biology 2009;28(1):3-7.
2008: Lindsay Morton; Sophia S Wang; Wendy Cozen; Martha S Linet; Nilanjan Chatterjee; Scott Davis; Richard K Severson; Joanne S Colt; Mohammad A Vasef; Nathaniel Rothman; Aaron Blair; Leslie Bernstein; Amanda J Cross; Anneclaire J De Roos; Eric A Engels; David W Hein; Deirdre Hill; Linda E Kelemen; Unhee Lim; Charles F Lynch; Maryjean Schenk; Sholom Wacholder; Mary H Ward; Shelia Hoar Zahm; STEPHEN CHANOCK; James Cerhan; Patricia Hartge
Etiologic heterogeneity among non-Hodgkin lymphoma subtypes.
Blood 2008;112(13):5150-60.
2008: David Barker; Jason M Walraven; Elizabeth H Ristagno; Mark A Doll; J.Christopher States; David W Hein
Quantitative tissue and gene-specific differences and developmental changes in Nat1, Nat2, and Nat3 mRNA expression in the rat.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(12):2445-51.
2008: David W Hein; Jean Bendaly; Jason R Neale; Mark A Doll
Systemic functional expression of N-acetyltransferase polymorphism in the F344 Nat2 congenic rat.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(12):2452-9.
2008: Yusheng Zhu; David W Hein
Functional effects of single nucleotide polymorphisms in the coding region of human N-acetyltransferase 1.
The pharmacogenomics journal 2008;8(5):339-48.
2008: Guihua Zhou; Xiaokun Li; David W Hein; Xilin Xiang; James P Marshall; Sumanth D Prabhu; Lu Cai
Metallothionein suppresses angiotensin II-induced nicotinamide adenine dinucleotide phosphate oxidase activation, nitrosative stress, apoptosis, and pathological remodeling in the diabetic heart.
Journal of the American College of Cardiology 2008;52(8):655-66.
2008: Jason M Walraven; Yu Zang; John O Trent; David W Hein
Structure/function evaluations of single nucleotide polymorphisms in human N-acetyltransferase 2.
Current drug metabolism 2008;9(6):471-86.
2008: Hideo Suzuki; Jeffrey S Morris; Yanan Li; Mark A Doll; David W Hein; Jun Liu; Li Jiao; Manal M Hassan; Rena S Day; Melissa L Bondy; James L Abbruzzese; Donghui Li
Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer.
Carcinogenesis 2008;29(6):1184-91.
2008: Robert C G Martin; David Barker; Mark A Doll; Sharon R Pine; Leah Mechanic; Elise D Bowman; Curtis C Harris; David W Hein
Manganese superoxide dismutase gene coding region polymorphisms lack clinical incidence in general population.
DNA and cell biology 2008;27(6):321-3.
2008: David W Hein; Sotiria Boukouvala; Denis M Grant; Rodney F Minchin; Edith Sim
Changes in consensus arylamine N-acetyltransferase gene nomenclature.
Pharmacogenetics and genomics 2008;18(4):367-8.
2008: Srivani Ravoori; Yi Feng; Jason R Neale; Jeyaprakash Jeyabalan; Cidambi Srinivasan; David W Hein; Ramesh C Gupta
Dose-dependent reduction of 3,2'-dimethyl-4-aminobiphenyl-derived DNA adducts in colon and liver of rats administered celecoxib.
Mutation research 2008;638(1-2):103-9.
2008: Larissa Wakefield; Valerie Cornish; Hilary Long; Akane Kawamura; Xiaoyan Zhang; David W Hein; Edith Sim
Mouse arylamine N-acetyltransferase 2 (Nat2) expression during embryogenesis: a potential marker for the developing neuroendocrine system.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2008;13(1):106-18.
2008: Jason M Walraven; John O Trent; David W Hein
Structure-function analyses of single nucleotide polymorphisms in human N-acetyltransferase 1.
Drug metabolism reviews 2008;40(1):169-84.
2008: Yi Feng; Jason R Neale; Mark A Doll; David W Hein
Chemoprevention of arylamine-induced colorectal aberrant crypts.
Experimental biology and medicine (Maywood, N.J.) 2008;233(1):71-5.
2007: Li Jiao; Mark A Doll; David W Hein; Melissa L Bondy; Manal M Hassan; James E Hixson; James L Abbruzzese; Donghui Li
Haplotype of N-acetyltransferase 1 and 2 and risk of pancreatic cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(11):2379-86.
2007: Anwar Husain; Jennifer A Loehle; David W Hein
Clinical pharmacogenetics in pediatric patients.
Pharmacogenomics 2007;8(10):1403-11.
2007: Jason M Walraven; David Barker; Mark A Doll; David W Hein
Tissue expression and genomic sequences of rat N-acetyltransferases rNat1, rNat2, rNat3, and Functional characterization of a novel rNat3*2 genetic variant.
Toxicological sciences : an official journal of the Society of Toxicology 2007;99(2):413-21.
2007: Anwar Husain; Xiaoyan Zhang; Mark A Doll; J.Christopher States; David Barker; David W Hein
Functional analysis of the human N-acetyltransferase 1 major promoter: quantitation of tissue expression and identification of critical sequence elements.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(9):1649-56.
2007: Lindsay Morton; Leslie Bernstein; Sophia S Wang; David W Hein; Nathaniel Rothman; Joanne S Colt; Scott Davis; James Cerhan; Richard K Severson; Robert Welch; Patricia Hartge; Shelia Hoar Zahm
Hair dye use, genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma.
Carcinogenesis 2007;28(8):1759-64.
2007: Yu Zang; Mark A Doll; Shuang Zhao; J.Christopher States; David W Hein
Functional characterization of single-nucleotide polymorphisms and haplotypes of human N-acetyltransferase 2.
Carcinogenesis 2007;28(8):1665-71.
2007: Jean Bendaly; Shuang Zhao; Jason R Neale; Kristin J Metry; Mark A Doll; J.Christopher States; William M Pierce; David W Hein
2-Amino-3,8-dimethylimidazo-[4,5-f]quinoxaline-induced DNA adduct formation and mutagenesis in DNA repair-deficient Chinese hamster ovary cells expressing human cytochrome P4501A1 and rapid or slow acetylator N-acetyltransferase 2.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(7):1503-9.
2007: Kristin J Metry; Shuang Zhao; Jason R Neale; Mark A Doll; J.Christopher States; W Glenn McGregor; William M Pierce; David W Hein
2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine-induced DNA adducts and genotoxicity in chinese hamster ovary (CHO) cells expressing human CYP1A2 and rapid or slow acetylator N-acetyltransferase 2.
Molecular carcinogenesis 2007;46(7):553-63.
2007: Jason M Walraven; John O Trent; David W Hein
Computational and experimental analyses of mammalian arylamine N-acetyltransferase structure and function.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(6):1001-7.
2007: Anwar Husain; Xiaoyan Zhang; Mark A Doll; J.Christopher States; David Barker; David W Hein
Identification of N-acetyltransferase 2 (NAT2) transcription start sites and quantitation of NAT2-specific mRNA in human tissues.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(5):721-7.
2007: Jay H Lubin; Manolis Kogevinas; Debra Silverman; Núria Malats; Montserrat Garcia-Closas; Adonina Tardón; David W Hein; Reina Garcia-Closas; Consol Serra; Mustafa Dosemeci; Alfredo Carrato; Nathaniel Rothman
Evidence for an intensity-dependent interaction of NAT2 acetylation genotype and cigarette smoking in the Spanish Bladder Cancer Study.
International journal of epidemiology 2007;36(1):236-41.
2007: Nathaniel Rothman; Montserrat Garcia-Closas; David W Hein
Commentary: Reflections on G. M. Lower and colleagues' 1979 study associating slow acetylator phenotype with urinary bladder cancer: meta-analysis, historical refinements of the hypothesis, and lessons learned.
International journal of epidemiology 2007;36(1):23-8.
2007: Suhal S Mahid; Daniel W Colliver; Nigel Crawford; Benjamin D Martini; Mark A Doll; David W Hein; Gary A Cobbs; Robert E Petras; Susan Galandiuk
Characterization of N-acetyltransferase 1 and 2 polymorphisms and haplotype analysis for inflammatory bowel disease and sporadic colorectal carcinoma.
BMC medical genetics 2007;8():28.
2007: Yu Zang; Shuang Zhao; Mark A Doll; J Christopher States; David W Hein
Functional characterization of the A411T (L137F) and G364A (D122N) genetic polymorphisms in human N-acetyltransferase 2.
Pharmacogenetics and genomics 2007;17(1):37-45.
2006: Jennifer A Loehle; Valerie Cornish; Larissa Wakefield; Mark A Doll; Jason R Neale; Yu Zang; Edith Sim; David W Hein
N-acetyltransferase (Nat) 1 and 2 expression in Nat2 knockout mice.
The Journal of pharmacology and experimental therapeutics 2006;319(2):724-8.
2006: Jason M Walraven; Mark A Doll; David W Hein
Identification and characterization of functional rat arylamine N-acetyltransferase 3: comparisons with rat arylamine N-acetyltransferases 1 and 2.
The Journal of pharmacology and experimental therapeutics 2006;319(1):369-75.
2006: Roxana Moslehi; Nilanjan Chatterjee; Timothy R Church; Jinbo Chen; Meredith Yeager; Joel L Weissfeld; David W Hein; Richard Hayes
Cigarette smoking, N-acetyltransferase genes and the risk of advanced colorectal adenoma.
Pharmacogenomics 2006;7(6):819-29.
2006: Payal Bhaiya; Sanjoy Roychowdhury; Piyush M Vyas; Mark A Doll; David W Hein; Craig K Svensson
Bioactivation, protein haptenation, and toxicity of sulfamethoxazole and dapsone in normal human dermal fibroblasts.
Toxicology and applied pharmacology 2006;215(2):158-67.
2006: David W Hein; Adrian J Fretland; Mark A Doll
Effects of single nucleotide polymorphisms in human N-acetyltransferase 2 on metabolic activation (O-acetylation) of heterocyclic amine carcinogens.
International journal of cancer. Journal international du cancer 2006;119(5):1208-11.
2006: Lindsay Morton; Maryjean Schenk; David W Hein; Scott Davis; Shelia Hoar Zahm; Wendy Cozen; James Cerhan; Patricia Hartge; Robert Welch; STEPHEN CHANOCK; Nathaniel Rothman; Sophia S Wang
Genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2) and risk of non-Hodgkin lymphoma.
Pharmacogenetics and genomics 2006;16(8):537-45.
2006: David Barker; Anwar Husain; Jason R Neale; Benjamin D Martini; Xiaoyan Zhang; Mark A Doll; J.Christopher States; David W Hein
Functional properties of an alternative, tissue-specific promoter for human arylamine N-acetyltransferase 1.
Pharmacogenetics and genomics 2006;16(7):515-25.
2006: Yusheng Zhu; David W Hein; Mark A Doll; Kristen K Reynolds; Ntei Abudu; Roland Valdes; Mark W Linder
Simultaneous determination of 7 N-acetyltransferase-2 single-nucleotide variations by allele-specific primer extension assay.
Clinical chemistry 2006;52(6):1033-9.
2006: David W Hein; Mark A Doll; Donald E Nerland; Adrian J Fretland
Tissue distribution of N-acetyltransferase 1 and 2 catalyzing the N-acetylation of 4-aminobiphenyl and O-acetylation of N-hydroxy-4-aminobiphenyl in the congenic rapid and slow acetylator Syrian hamster.
Molecular carcinogenesis 2006;45(4):230-8.
2006: David W Hein
N-acetyltransferase 2 genetic polymorphism: effects of carcinogen and haplotype on urinary bladder cancer risk.
Oncogene 2006;25(11):1649-58.
2006: Robert C G Martin; Jiyoung Ahn; Susan Nowell; David W Hein; Mark A Doll; Benjamin D Martini; Christine B Ambrosone
Association between manganese superoxide dismutase promoter gene polymorphism and breast cancer survival.
Breast cancer research : BCR 2006;8(4):R45.
2006: Xiaoyan Zhang; Jason C Lambert; Mark A Doll; Jason M Walraven; Gavin E Arteel; David W Hein
4,4'-methylenedianiline-induced hepatotoxicity is modified by N-acetyltransferase 2 (NAT2) acetylator polymorphism in the rat.
The Journal of pharmacology and experimental therapeutics 2006;316(1):289-94.
2006: Donghui Li; Li Jiao; Yanan Li; Mark A Doll; David W Hein; Melissa L Bondy; Douglas B Evans; Robert A Wolff; Renato Lenzi; Peter W T Pisters; James L Abbruzzese; Manal M Hassan
Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancer.
Carcinogenesis 2006;27(1):103-11.
2005: Montserrat García-Closas; Núria Malats; Debra Silverman; Mustafa Dosemeci; Manolis Kogevinas; David W Hein; Adonina Tardón; Consol Serra; Alfredo Carrato; Reina García-Closas; Josep Lloreta; Gemma Castaño-Vinyals; Meredith Yeager; Robert Welch; STEPHEN CHANOCK; Nilanjan Chatterjee; Sholom Wacholder; Claudine Samanic; Montserrat Torà; Francisco Fernández; Francisco X Real; Nathaniel Rothman
NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses.
Lancet 2005;366(9486):649-59.
2005: Robert C G Martin; Qing Lan; Kalista Hughes; Mark A Doll; Benjamin D Martini; Jolanta Lissowska; Witold Zatonski; Nathaniel Rothman; David W Hein
No apparent association between genetic polymorphisms (-102 C>T) and (-9 T>C) in the human manganese superoxide dismutase gene and gastric cancer(1).
The Journal of surgical research 2005;124(1):92-7.
2005: David W Hein; Mark A Doll
TaqMan real time-polymerase chain reaction methods for determination of nucleotide polymorphisms in human N-acetyltransferase-1 (NAT1) and -2 (NAT2).
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] 2005;Chapter 4():Unit4.15.
2004: Robert C G Martin; Kalista Hughes; Mark A Doll; Qing Lan; Benjamin D Martini; Jolanta Lissowska; Nathaniel Rothman; David W Hein
Method for determination of (-102C>T) single nucleotide polymorphism in the human manganese superoxide dismutase promoter.
BMC genetics 2004;5():33.
2004: Yu Zang; Shuang Zhao; Mark A Doll; J.Christopher States; David W Hein
The T341C (Ile114Thr) polymorphism of N-acetyltransferase 2 yields slow acetylator phenotype by enhanced protein degradation.
Pharmacogenetics 2004;14(11):717-23.
2004: Luping Guo; Katharine S Richardson; Lindsay M Tucker; Mark A Doll; David W Hein; Gavin E Arteel
Role of the renin-angiotensin system in hepatic ischemia reperfusion injury in rats.
Hepatology (Baltimore, Md.) 2004;40(3):583-9.
2004: Anne C Deitz; Nathaniel Rothman; Timothy R Rebbeck; Richard Hayes; Wong-Ho Chow; Wei Zheng; David W Hein; Montserrat García-Closas
Impact of misclassification in genotype-exposure interaction studies: example of N-acetyltransferase 2 (NAT2), smoking, and bladder cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004;13(9):1543-6.
2004: Anwar Husain; David Barker; J.Christopher States; Mark A Doll; David W Hein
Identification of the major promoter and non-coding exons of the human arylamine N-acetyltransferase 1 gene (NAT1).
Pharmacogenetics 2004;14(7):397-406.
2004: Larry I Palmer; Robert C G Martin; David W Hein
Chemopreventive drug treatment in subjects with genetic predisposition to cancer: prescriber liability and healthcare disparities.
Pharmacogenomics 2004;5(3):319-29.
2003: Adrian J Fretland; Uday S Devanaboyina; Mark A Doll; Shuang Zhao; Gong H Xiao; David W Hein
Metabolic activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Syrian hamsters congenic at the N-acetyltransferase 2 (NAT2) locus.
Toxicological sciences : an official journal of the Society of Toxicology 2003;74(2):253-9.
2003: Qing Lan; Nathaniel Rothman; Wong-Ho Chow; Jolanta Lissowska; Mark A Doll; Gong H Xiao; Witold Zatonski; David W Hein
No apparent association between NAT1 and NAT2 genotypes and risk of stomach cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2003;12(4):384-6.
2003: David W Hein; Mark A Doll; Gong H Xiao; Yi Feng
Prostate expression of N-acetyltransferase 1 (NAT1) and 2 (NAT2) in rapid and slow acetylator congenic Syrian hamster.
Pharmacogenetics 2003;13(3):159-67.
2002: David W Hein
Molecular genetics and function of NAT1 and NAT2: role in aromatic amine metabolism and carcinogenesis.
Mutation research 2002;506-507():65-77.
2002: Yuanqi Zhu; Mark A Doll; David W Hein
Functional genomics of C190T single nucleotide polymorphism in human N-acetyltransferase 2.
Biological chemistry 2002;383(6):983-7.
2002: William M O'Neil; Rodger D MacArthur; Marti J Farrough; Mark A Doll; Adrian J Fretland; David W Hein; Lawrence R Crane; Craig K Svensson
Acetylator phenotype and genotype in HIV-infected patients with and without sulfonamide hypersensitivity.
Journal of clinical pharmacology 2002;42(6):613-9.
2002: Naoko Ishibe; Rashmi Sinha; David W Hein; Martin Kulldorff; Paul T Strickland; Adrian J Fretland; Wong-Ho Chow; Fred F Kadlubar; Nicholas P Lang; Nathaniel Rothman
Genetic polymorphisms in heterocyclic amine metabolism and risk of colorectal adenomas.
Pharmacogenetics 2002;12(2):145-50.
2002: Mark A Doll; David W Hein
Rapid genotype method to distinguish frequent and/or functional polymorphisms in human N-acetyltransferase-1.
Analytical biochemistry 2002;301(2):328-32.
2002: David W Hein; Matthew A Leff; Naoko Ishibe; Rashmi Sinha; Harold A Frazier; Mark A Doll; Gong H Xiao; Martin C Weinrich; Neil E Caporaso
Association of prostate cancer with rapid N-acetyltransferase 1 (NAT1*10) in combination with slow N-acetyltransferase 2 acetylator genotypes in a pilot case-control study.
Environmental and molecular mutagenesis 2002;40(3):161-7.
2002: Adrian J Fretland; Mark A Doll; Yuanqi Zhu; Leo Smith; Matthew A Leff; David W Hein
Effect of nucleotide substitutions in N-acetyltransferase-1 on N-acetylation (deactivation) and O-acetylation (activation) of arylamine carcinogens: implications for cancer predisposition.
Cancer detection and prevention 2002;26(1):10-4.
2001: Q Lan; Wong-Ho Chow; Jolanta Lissowska; David W Hein; K Buetow; Lawrence S Engel; B Ji; W Zatonski; Nathaniel Rothman
Glutathione S-transferase genotypes and stomach cancer in a population-based case-control study in Warsaw, Poland.
Pharmacogenetics 2001;11(8):655-61.
2001: Adrian J Fretland; Mark A Doll; Matthew A Leff; David W Hein
Functional characterization of nucleotide polymorphisms in the coding region of N-acetyltransferase 1.
Pharmacogenetics 2001;11(6):511-20.
2001: Adrian J Fretland; Matthew A Leff; Mark A Doll; David W Hein
Functional characterization of human N-acetyltransferase 2 (NAT2) single nucleotide polymorphisms.
Pharmacogenetics 2001;11(3):207-15.
2001: Adrian J Fretland; Uday S Devanaboyina; Yi Feng; Matthew A Leff; Gong H Xiao; Stephanie J Webb; David W Hein
Oral administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) yields PhIP-DNA adducts but not tumors in male Syrian hamsters congenic at the N-acetyltransferase 2 (NAT2) locus.
Toxicological sciences : an official journal of the Society of Toxicology 2001;59(2):226-30.
2001: Adrian J Fretland; Uday S Devanaboyina; N A Nangju; Matthew A Leff; Gong H Xiao; Stephanie J Webb; Mark A Doll; David W Hein
DNA adduct levels and absence of tumors in female rapid and slow acetylator congenic hamsters administered the rat mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine.
Journal of biochemical and molecular toxicology 2001;15(1):26-33.
2001: Mark A Doll; David W Hein
Comprehensive human NAT2 genotype method using single nucleotide polymorphism-specific polymerase chain reaction primers and fluorogenic probes.
Analytical biochemistry 2001;288(1):106-8.
2000: David W Hein; Charlene A McQueen; Denis M Grant; Geoffrey H Goodfellow; Fred F Kadlubar; Wendell W Weber
Pharmacogenetics of the arylamine N-acetyltransferases: a symposium in honor of Wendell W. Weber.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(12):1425-32.
2000: Anne C Deitz; Wei Zheng; Matthew A Leff; M Gross; W Q Wen; Mark A Doll; Gong H Xiao; Aaron R Folsom; David W Hein
N-Acetyltransferase-2 genetic polymorphism, well-done meat intake, and breast cancer risk among postmenopausal women.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2000;9(9):905-10.
2000: Inger-Lise Steffensen; Adrian J Fretland; Jan Erik Paulsen; Yi Feng; Tor Jacob Eide; Uday S Devanaboyina; David W Hein; Jan Alexander
DNA adduct levels and intestinal lesions in congenic rapid and slow acetylator syrian hamsters admi food mutagens 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) or 2-amino-3-methylimidazo[4,5-f]quinoline (IQ).
Pharmacology & toxicology 2000;86(6):257-63.
2000: Timothy P Reilly; Lawrence H Lash; Mark A Doll; David W Hein; Patrick M Woster; Craig K Svensson
A role for bioactivation and covalent binding within epidermal keratinocytes in sulfonamide-induced cutaneous drug reactions.
The Journal of investigative dermatology 2000;114(6):1164-73.
2000: M Purewal; Marco De Velasco; Adrian J Fretland; David W Hein; Michael J Wargovich
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine induces a higher number of aberrant crypt foci in Fischer 344 (rapid) than in Wistar Kyoto (slow) acetylator inbred rats.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2000;9(5):529-32.
2000: David W Hein
N-Acetyltransferase genetics and their role in predisposition to aromatic and heterocyclic amine-induced carcinogenesis.
Toxicology letters 2000;112-113():349-56.
2000: William M O'Neil; Robert K Drobitch; Rodger D MacArthur; Marti J Farrough; Mark A Doll; Adrian J Fretland; David W Hein; Lawrence R Crane; Craig K Svensson
Acetylator phenotype and genotype in patients infected with HIV: discordance between methods for phenotype determination and genotype.
Pharmacogenetics 2000;10(2):171-82.
2000: M Purewal; Adrian J Fretland; H A Schut; David W Hein; Michael J Wargovich
Association between acetylator genotype and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) DNA adduct formation in colon and prostate of inbred Fischer 344 and Wistar Kyoto rats.
Cancer letters 2000;149(1-2):53-60.
2000: David W Hein; Mark A Doll; Adrian J Fretland; Matthew A Leff; Stephanie J Webb; Gong H Xiao; Uday S Devanaboyina; N A Nangju; Yi Feng
Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2000;9(1):29-42.
1999: Matthew A Leff; Adrian J Fretland; Mark A Doll; David W Hein
Novel human N-acetyltransferase 2 alleles that differ in mechanism for slow acetylator phenotype.
The Journal of biological chemistry 1999;274(49):34519-22.
1999: Matthew A Leff; Paul N Epstein; Mark A Doll; Adrian J Fretland; Uday S Devanaboyina; TD Rustan; David W Hein
Prostate-specific human N-acetyltransferase 2 (NAT2) expression in the mouse.
The Journal of pharmacology and experimental therapeutics 1999;290(1):182-7.
1999: Yi Feng; John W Finley; Cindy D Davis; WK Becker; Adrian J Fretland; David W Hein
Dietary selenium reduces the formation of aberrant crypts in rats administered 3,2'-dimethyl-4-aminobiphenyl.
Toxicology and applied pharmacology 1999;157(1):36-42.
1999: W Jiang; Yi Feng; David W Hein
Higher DNA adduct levels in urinary bladder and prostate of slow acetylator inbred rats administered 3,2'-dimethyl-4-aminobiphenyl.
Toxicology and applied pharmacology 1999;156(3):187-94.
1999: Wei Zheng; Anne C Deitz; D R Campbell; W Q Wen; JR Cerhan; Thomas A Sellers; Aaron R Folsom; David W Hein
N-acetyltransferase 1 genetic polymorphism, cigarette smoking, well-done meat intake, and breast cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1999;8(3):233-9.
1999: J E Hulla; M S Miller; J A Taylor; David W Hein; C E Furlong; C J Omiecinski; T A Kunkel
Symposium overview: the role of genetic polymorphism and repair deficiencies in environmental disease.
Toxicological sciences : an official journal of the Society of Toxicology 1999;47(2):135-43.
1999: Cindy D Davis; Y Feng; David W Hein; John W Finley
The chemical form of selenium influences 3,2'-dimethyl-4-aminobiphenyl-DNA adduct formation in rat colon.
The Journal of nutrition 1999;129(1):63-9.
1998: Yi Feng; TD Rustan; Adrian J Fretland; A M Cooley; K J Lee; WK Becker; David W Hein
A rapid and sensitive method for detection of urinary bladder tumors in rodents.
Proceedings of the Western Pharmacology Society 1998;41():11-3.
1997: Anne C Deitz; Mark A Doll; David W Hein
A restriction fragment length polymorphism assay that differentiates human N-acetyltransferase-1 (NAT1) alleles.
Analytical biochemistry 1997;253(2):219-24.
1997: Yi Feng; Adrian J Fretland; TD Rustan; W Jiang; WK Becker; David W Hein
Higher frequency of aberrant crypt foci in rapid than slow acetylator inbred rats administered the colon carcinogen 3,2'-dimethyl-4-aminobiphenyl.
Toxicology and applied pharmacology 1997;147(1):56-62.
1997: H Zaher; W J Lindblad; W Jiang; Mark A Doll; David W Hein; Craig K Svensson
Acetyl CoA:arylamine N-acetyltransferase activity in rat hepatocytes cultured on different extracellular matrices.
Toxicology in vitro : an international journal published in association with BIBRA 1997;11(3):271-83.
1997: David W Hein; Mark A Doll; Adrian J Fretland; K Gray; Anne C Deitz; Yi Feng; W Jiang; TD Rustan; S L Satran; T R Wilkie
Rodent models of the human acetylation polymorphism: comparisons of recombinant acetyltransferases.
Mutation research 1997;376(1-2):101-6.
1997: Mark A Doll; W Jiang; Anne C Deitz; TD Rustan; David W Hein
Identification of a novel allele at the human NAT1 acetyltransferase locus.
Biochemical and biophysical research communications 1997;233(3):584-91.
1997: Adrian J Fretland; Mark A Doll; K Gray; Yi Feng; David W Hein
Cloning, sequencing, and recombinant expression of NAT1, NAT2, and NAT3 derived from the C3H/HeJ (rapid) and A/HeJ (slow) acetylator inbred mouse: functional characterization of the activation and deactivation of aromatic amine carcinogens.
Toxicology and applied pharmacology 1997;142(2):360-6.
1997: Adrian J Fretland; Yi Feng; David W Hein
DNA adduct levels in rapid and slow acetylator inbred rats administered 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Proceedings of the Western Pharmacology Society 1997;40():9-12.
1997: David W Hein; R J Ferguson; Mark A Doll; Anne C Deitz
Recombinant expression and catalytic analysis of rapid and slow acetylator Syrian hamster chimeric NAT2 alleles.
Archives of toxicology 1997;71(5):306-13.
1996: Yi Feng; W Jiang; David W Hein
2-Aminofluorene-DNA adduct levels in tumor-target and nontarget organs of rapid and slow acetylator Syrian hamsters congenic at the NAT2 locus.
Toxicology and applied pharmacology 1996;141(1):248-55.
1996: Yi Feng; W Jiang; Anne C Deitz; David W Hein
3,2'-Dimethyl-4-aminobiphenyl-DNA adduct formation in tumor target and nontarget organs of rapid and slow acetylator Syrian hamsters cogenic at the NAT2 locus.
Toxicology and applied pharmacology 1996;140(2):315-21.
1996: T V Zenser; V M Lakshmi; TD Rustan; Mark A Doll; Anne C Deitz; B B Davis; David W Hein
Human N-acetylation of benzidine: role of NAT1 and NAT2.
Cancer research 1996;56(17):3941-7.
1996: R J Ferguson; Mark A Doll; TD Rustan; David W Hein
Cloning, expression, and functional characterization of rapid and slow acetylator polymorphic N-acetyl-transferase encoding genes of the Syrian hamster.
Pharmacogenetics 1996;6(1):55-66.
1996: Yi Feng; R J Wagner; Adrian J Fretland; W K Becker; A M Cooley; T P Pretlow; K J Lee; David W Hein
Acetylator genotype (NAT2)-dependent formation of aberrant crypts in congenic Syrian hamsters administered 3,2'-dimethyl-4-aminobiphenyl.
Cancer research 1996;56(3):527-31.
1995: Mark A Doll; Adrian J Fretland; Anne C Deitz; David W Hein
Determination of human NAT2 acetylator genotype by restriction fragment-length polymorphism and allele-specific amplification.
Analytical biochemistry 1995;231(2):413-20.
1995: David W Hein; Mark A Doll; TD Rustan; R J Ferguson
Metabolic activation of N-hydroxyarylamines and N-hydroxyarylamides by 16 recombinant human NAT2 allozymes: effects of 7 specific NAT2 nucleic acid substitutions.
Cancer research 1995;55(16):3531-6.
1995: Mark A Doll; David W Hein
Cloning, sequencing and expression of NAT1 and NAT2 encoding genes from rapid and slow acetylator inbred rats.
Pharmacogenetics 1995;5(4):247-51.
1995: David W Hein; Mark A Doll; R J Ferguson
Metabolic activation of carcinogenic arylamines by rapid acetylator, slow acetylator, and chimeric recombinant Syrian hamster NAT2 allozymes.
Proceedings of the Western Pharmacology Society 1995;38():59-62.
1994: David W Hein; R J Ferguson; Mark A Doll; TD Rustan; K Gray
Molecular genetics of human polymorphic N-acetyltransferase: enzymatic analysis of 15 recombinant wild-type, mutant, and chimeric NAT2 allozymes.
Human molecular genetics 1994;3(5):729-34.
1994: R J Ferguson; Mark A Doll; TD Rustan; K Gray; David W Hein
Cloning, expression, and functional characterization of two mutant (NAT2(191) and NAT2(341/803)) and wild-type human polymorphic N-acetyltransferase (NAT2) alleles.
Drug metabolism and disposition: the biological fate of chemicals 1994;22(3):371-6.
1994: R J Ferguson; Mark A Doll; TD Rustan; Barbara R Baumstark; David W Hein
Syrian hamster monomorphic N-acetyltransferase (NAT1) alleles: amplification, cloning, sequencing, and expression in E. coli.
Pharmacogenetics 1994;4(2):82-90.
1994: R J Ferguson; Mark A Doll; Barbara R Baumstark; David W Hein
Polymorphic arylamine N-acetyltransferase encoding gene (NAT2) from homozygous rapid and slow acetylator congenic Syrian hamsters.
Gene 1994;140(2):247-9.
1994: David W Hein; Mark A Doll; TD Rustan; K Gray; R J Ferguson; Yi Feng
Construction of Syrian hamster lines congenic at the polymorphic acetyltransferase locus (NAT2): acetylator genotype-dependent N- and O-acetylation of arylamine carcinogens.
Toxicology and applied pharmacology 1994;124(1):16-24.
1994: Yi Feng; TD Rustan; R J Ferguson; Mark A Doll; David W Hein
Acetylator genotype-dependent formation of 2-aminofluorene-hemoglobin adducts in rapid and slow acetylator Syrian hamsters congenic at the NAT2 locus.
Toxicology and applied pharmacology 1994;124(1):10-5.
1994: David W Hein; TD Rustan; R J Ferguson; Mark A Doll; K Gray
Metabolic activation of aromatic and heterocyclic N-hydroxyarylamines by wild-type and mutant recombinant human NAT1 and NAT2 acetyltransferases.
Archives of toxicology 1994;68(2):129-33.
1993: David W Hein; Mark A Doll; TD Rustan; K Gray; Yi Feng; R J Ferguson; D M Grant
Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases.
Carcinogenesis 1993;14(8):1633-8.
1993: David W Hein; Mark A Doll; K Gray; TD Rustan; R J Ferguson
Metabolic activation of N-hydroxy-2-aminofluorene and N-hydroxy-2-acetylaminofluorene by monomorphic N-acetyltransferase (NAT1) and polymorphic N-acetyltransferase (NAT2) in colon cytosols of Syrian hamsters congenic at the NAT2 locus.
Cancer research 1993;53(3):509-14.
1993: J W Rodriguez; Ward G Kirlin; R J Ferguson; Mark A Doll; K Gray; TD Rustan; M E Lee; K Kemp; P Urso; David W Hein
Human acetylator genotype: relationship to colorectal cancer incidence and arylamine N-acetyltransferase expression in colon cytosol.
Archives of toxicology 1993;67(7):445-52.
1992: David W Hein; TD Rustan; Mark A Doll; K D Bucher; R J Ferguson; Yi Feng; E J Furman; K Gray
Acetyltransferases and susceptibility to chemicals.
Toxicology letters 1992;64-65 Spec No():123-30.
1992: T J Flammang; Toks Yerokun; Matthew Bryant; Letha H Couch; Ward G Kirlin; K J Lee; F Ogolla; R J Ferguson; G Talaska; David W Hein
Hemoglobin adduct and hepatic- and urinary bladder-DNA adduct levels in rapid and slow acetylator Syrian inbred hamsters administered 2-aminofluorene.
The Journal of pharmacology and experimental therapeutics 1992;260(2):865-71.
1992: David W Hein; TD Rustan; W J Martin; K D Bucher; L S Miller; E J Furman
Acetylator genotype-dependent N-acetylation of arylamines in vivo and in vitro by hepatic and extrahepatic organ cytosols of Syrian hamsters congenic at the polymorphic acetyltransferase locus.
Archives of toxicology 1992;66(2):112-7.
1991: David W Hein; TD Rustan; K D Bucher; L S Miller
Polymorphic and monomorphic expression of arylamine carcinogen N-acetyltransferase isozymes in tumor target organ cytosols of Syrian hamsters congenic at the polymorphic acetyltransferase locus.
The Journal of pharmacology and experimental therapeutics 1991;259(2):699-704.
1991: David W Hein; TD Rustan; K D Bucher; W J Martin; E J Furman
Acetylator phenotype-dependent and -independent expression of arylamine N-acetyltransferase isozymes in rapid and slow acetylator inbred rat liver.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(5):933-7.
1991: David W Hein; TD Rustan; K D Bucher; E J Furman; W J Martin
Extrahepatic expression of the N-acetylation polymorphism toward arylamine carcinogens in tumor target organs of an inbred rat model.
The Journal of pharmacology and experimental therapeutics 1991;258(1):232-6.
1991: Ward G Kirlin; F Ogolla; A F Andrews; A Trinidad; R J Ferguson; Toks Yerokun; M Mpezo; David W Hein
Acetylator genotype-dependent expression of arylamine N-acetyltransferase in human colon cytosol from non-cancer and colorectal cancer patients.
Cancer research 1991;51(2):549-55.
1991: David W Hein
Genetic regulation of N-acetyltransferase in target organs of arylamine tumors: homologous expression in human and hamster bladder and colon.
Proceedings of the Western Pharmacology Society 1991;34():55-60.
1990: A Trinidad; David W Hein; TD Rustan; R J Ferguson; L S Miller; K D Bucher; Ward G Kirlin; F Ogolla; A F Andrews
Purification of hepatic polymorphic arylamine N-acetyltransferase from homozygous rapid acetylator inbred hamster: identity with polymorphic N-hydroxyarylamine-O-acetyltransferase.
Cancer research 1990;50(24):7942-9.
1990: F Ogolla; R J Ferguson; Ward G Kirlin; A Trinidad; A F Andrews; M Mpezo; David W Hein
Acetylator genotype-dependent expression of arylamine N-acetyltransferase and N-hydroxyarylamine O-acetyltransferase in Syrian inbred hamster intestine and colon. Identity with the hepatic acetylation polymorphism.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(5):680-5.
1990: Toks Yerokun; David W Hein; R J Ferguson; F Ogolla; R H Heflich; T Y Minor; A Trinidad; Ward G Kirlin; A F Andrews
Relationship of Syrian inbred hamster acetylator genotype to the mutagenic activation of 2-aminofluorene.
Mutagenesis 1990;5(3):233-9.
1990: David W Hein; A Trinidad; Toks Yerokun; Ward G Kirlin; F Ogolla; R J Ferguson; A F Andrews
Genetic regulation of acetyltransferases in the Syrian inbred hamster: a model for man.
Progress in clinical and biological research 1990;340B():115-24.
1989: Ward G Kirlin; A Trinidad; Toks Yerokun; F Ogolla; R J Ferguson; A F Andrews; P K Brady; David W Hein
Polymorphic expression of acetyl coenzyme A-dependent arylamine N-acetyltransferase and acetyl coenzyme A-dependent O-acetyltransferase-mediated activation of N-hydroxyarylamines by human bladder cytosol.
Cancer research 1989;49(9):2448-54.
1989: A Trinidad; Ward G Kirlin; F Ogolla; A F Andrews; Toks Yerokun; R J Ferguson; P K Brady; David W Hein
Kinetic characterization of acetylator genotype-dependent and -independent N-acetyltransferase isozymes in homozygous rapid and slow acetylator inbred hamster liver cytosol.
Drug metabolism and disposition: the biological fate of chemicals 1989;17(3):238-47.
1989: Toks Yerokun; Ward G Kirlin; A Trinidad; R J Ferguson; F Ogolla; A F Andrews; P K Brady; David W Hein
Identification and kinetic characterization of acetylator genotype-dependent and -independent arylamine carcinogen N-acetyltransferases in hamster bladder cytosol.
Drug metabolism and disposition: the biological fate of chemicals 1989;17(3):231-7.
1988: David W Hein; A Trinidad; Toks Yerokun; R J Ferguson; Ward G Kirlin; Wendell W Weber
Genetic control of acetyl coenzyme A-dependent arylamine N-acetyltransferase, hydrazine N-acetyltransferase, and N-hydroxy-arylamine O-acetyltransferase enzymes in C57BL/6J, A/J, AC57F1, and the rapid and slow acetylator A.B6 and B6.A congenic inbred mouse.
Drug metabolism and disposition: the biological fate of chemicals 1988;16(3):341-7.
1987: David W Hein; T J Flammang; Ward G Kirlin; A Trinidad; F Ogolla
Acetylator genotype-dependent metabolic activation of carcinogenic N-hydroxyarylamines by S-acetyl coenzyme A-dependent enzymes of inbred hamster tissue cytosols: relationship to arylamine N-acetyltransferase.
Carcinogenesis 1987;8(12):1767-74.
1987: David W Hein; Ward G Kirlin; Toks Yerokun; A Trinidad; F Ogolla
Inheritance of acetylator genotype-dependent arylamine N-acetyltransferase in hamster bladder cytosol.
Carcinogenesis 1987;8(5):647-52.
1987: David W Hein; Ward G Kirlin; F Ogolla; A Trinidad
Extrahepatic expression of N-acetylator genotype in the inbred hamster.
Drug metabolism and disposition: the biological fate of chemicals 1987;15(1):68-73.
1986: David W Hein; Ward G Kirlin; R J Ferguson; L K Thompson; F Ogolla
Identification and inheritance of inbred hamster N-acetyltransferase isozymes in peripheral blood.
The Journal of pharmacology and experimental therapeutics 1986;239(3):823-8.
1986: David W Hein; Ward G Kirlin; F Ogolla; A Trinidad; L K Thompson; R J Ferguson
The role of acetylator genotype on hepatic and extrahepatic acetylation, deacetylation, and sulfation of 2-aminofluorene, 2-acetylaminofluorene, and N-hydroxy-2-acetylaminofluorene in the inbred hamster.
Drug metabolism and disposition: the biological fate of chemicals 1986;14(5):566-73.
1985: David W Hein; Ward G Kirlin; R J Ferguson; Wendell W Weber
Biochemical investigation of the basis for the genetic N-acetylation polymorphism in the inbred hamster.
The Journal of pharmacology and experimental therapeutics 1985;234(2):358-64.
1985: David W Hein; Ward G Kirlin; R J Ferguson; Wendell W Weber
Inheritance of liver N-acetyltransferase activity in the rapid and slow acetylator inbred hamster.
The Journal of pharmacology and experimental therapeutics 1985;233(3):584-7.