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David Hein

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Acetylation

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Publications

TOP 3
Bendaly Jean; Doll Mark A; Millner Lori M; Metry Kristin J; Smith Ned B; Pierce William M; Hein David W
Differences between human slow N-acetyltransferase 2 alleles in levels of 4-aminobiphenyl-induced DNA adducts and mutations.
Baumgartner Kathy B; Schlierf Thomas J; Yang Dongyan; Doll Mark A; Hein David W
N-acetyltransferase 2 genotype modification of active cigarette smoking on breast cancer risk among hispanic and non-hispanic white women.
Metry Kristin J; Neale Jason R; Bendaly Jean; Smith Ned B; Pierce William M; Hein David W
Effect of N-acetyltransferase 2 polymorphism on tumor target tissue DNA adduct levels in rapid and slow acetylator congenic rats administered 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine or 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline.

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All Publications

2009: Bendaly Jean; Doll Mark A; Millner Lori M; Metry Kristin J; Smith Ned B; Pierce William M; Hein David W
Differences between human slow N-acetyltransferase 2 alleles in levels of 4-aminobiphenyl-induced DNA adducts and mutations.
Mutation research 2009;671(1-2):13-9.
2009: Baumgartner Kathy B; Schlierf Thomas J; Yang Dongyan; Doll Mark A; Hein David W
N-acetyltransferase 2 genotype modification of active cigarette smoking on breast cancer risk among hispanic and non-hispanic white women.
Toxicological sciences : an official journal of the Society of Toxicology 2009;112(1):211-20.
2009: Metry Kristin J; Neale Jason R; Bendaly Jean; Smith Ned B; Pierce William M; Hein David W
Effect of N-acetyltransferase 2 polymorphism on tumor target tissue DNA adduct levels in rapid and slow acetylator congenic rats administered 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine or 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(11):2123-6.
2009: Hein David W
N-acetyltransferase SNPs: emerging concepts serve as a paradigm for understanding complexities of personalized medicine.
Expert opinion on drug metabolism & toxicology 2009;5(4):353-66.
2008: Barker David F; Walraven Jason M; Ristagno Elizabeth H; Doll Mark A; States J Christopher; Hein David W
Quantitative tissue and gene-specific differences and developmental changes in Nat1, Nat2, and Nat3 mRNA expression in the rat.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(12):2445-51.
2008: Hein David W; Bendaly Jean; Neale Jason R; Doll Mark A
Systemic functional expression of N-acetyltransferase polymorphism in the F344 Nat2 congenic rat.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(12):2452-9.
2008: Morton Lindsay M; Wang Sophia S; Cozen Wendy; Linet Martha S; Chatterjee Nilanjan; Davis Scott; Severson Richard K; Colt Joanne S; Vasef Mohammad A; Rothman Nathaniel; Blair Aaron; Bernstein Leslie; Cross Amanda J; De Roos Anneclaire J; Engels Eric A; Hein David W; Hill Deirdre A; Kelemen Linda E; Lim Unhee; Lynch Charles F; Schenk Maryjean; Wacholder Sholom; Ward Mary H; Hoar Zahm Shelia; Chanock Stephen J; Cerhan James R; Hartge Patricia
Etiologic heterogeneity among non-Hodgkin lymphoma subtypes.
Blood 2008;112(13):5150-60.
2008: Zhu Y; Hein D W
Functional effects of single nucleotide polymorphisms in the coding region of human N-acetyltransferase 1.
The pharmacogenomics journal 2008;8(5):339-48.
2008: Zhou Guihua; Li Xiaokun; Hein David W; Xiang Xilin; Marshall James P; Prabhu Sumanth D; Cai Lu
Metallothionein suppresses angiotensin II-induced nicotinamide adenine dinucleotide phosphate oxidase activation, nitrosative stress, apoptosis, and pathological remodeling in the diabetic heart.
Journal of the American College of Cardiology 2008;52(8):655-66.
2008: Walraven Jason M; Zang Yu; Trent John O; Hein David W
Structure/function evaluations of single nucleotide polymorphisms in human N-acetyltransferase 2.
Current drug metabolism 2008;9(6):471-86.
2008: Suzuki Hideo; Morris Jeffrey S; Li Yanan; Doll Mark A; Hein David W; Liu Jun; Jiao Li; Hassan Manal M; Day Rena S; Bondy Melissa L; Abbruzzese James L; Li Donghui
Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer.
Carcinogenesis 2008;29(6):1184-91.
2008: Martin Robert C G; Barker David F; Doll Mark A; Pine Sharon R; Mechanic Leah; Bowman Elise D; Harris Curtis C; Hein David W
Manganese superoxide dismutase gene coding region polymorphisms lack clinical incidence in general population.
DNA and cell biology 2008;27(6):321-3.
2008: Hein David W; Boukouvala Sotiria; Grant Denis M; Minchin Rodney F; Sim Edith
Changes in consensus arylamine N-acetyltransferase gene nomenclature.
Pharmacogenetics and genomics 2008;18(4):367-8.
2008: Ravoori Srivani; Feng Yi; Neale Jason R; Jeyabalan Jeyaprakash; Srinivasan Cidambi; Hein David W; Gupta Ramesh C
Dose-dependent reduction of 3,2'-dimethyl-4-aminobiphenyl-derived DNA adducts in colon and liver of rats administered celecoxib.
Mutation research 2008;638(1-2):103-9.
2008: Wakefield Larissa; Cornish Valerie; Long Hilary; Kawamura Akane; Zhang Xiaoyan; Hein David W; Sim Edith
Mouse arylamine N-acetyltransferase 2 (Nat2) expression during embryogenesis: a potential marker for the developing neuroendocrine system.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2008;13(1):106-18.
2008: Feng Yi; Neale Jason R; Doll Mark A; Hein David W
Chemoprevention of arylamine-induced colorectal aberrant crypts.
Experimental biology and medicine (Maywood, N.J.) 2008;233(1):71-5.
2008: Walraven Jason M; Trent John O; Hein David W
Structure-function analyses of single nucleotide polymorphisms in human N-acetyltransferase 1.
Drug metabolism reviews 2008;40(1):169-84.
2007: Jiao Li; Doll Mark A; Hein David W; Bondy Melissa L; Hassan Manal M; Hixson James E; Abbruzzese James L; Li Donghui
Haplotype of N-acetyltransferase 1 and 2 and risk of pancreatic cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(11):2379-86.
2007: Husain Anwar; Loehle Jennifer A; Hein David W
Clinical pharmacogenetics in pediatric patients.
Pharmacogenomics 2007;8(10):1403-11.
2007: Walraven Jason M; Barker David F; Doll Mark A; Hein David W
Tissue expression and genomic sequences of rat N-acetyltransferases rNat1, rNat2, rNat3, and Functional characterization of a novel rNat3*2 genetic variant.
Toxicological sciences : an official journal of the Society of Toxicology 2007;99(2):413-21.
2007: Husain Anwar; Zhang Xiaoyan; Doll Mark A; States J Christopher; Barker David F; Hein David W
Functional analysis of the human N-acetyltransferase 1 major promoter: quantitation of tissue expression and identification of critical sequence elements.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(9):1649-56.
2007: Morton Lindsay M; Bernstein Leslie; Wang Sophia S; Hein David W; Rothman Nathaniel; Colt Joanne S; Davis Scott; Cerhan James R; Severson Richard K; Welch Robert; Hartge Patricia; Zahm Shelia Hoar
Hair dye use, genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma.
Carcinogenesis 2007;28(8):1759-64.
2007: Zang Yu; Doll Mark A; Zhao Shuang; States J Christopher; Hein David W
Functional characterization of single-nucleotide polymorphisms and haplotypes of human N-acetyltransferase 2.
Carcinogenesis 2007;28(8):1665-71.
2007: Bendaly Jean; Zhao Shuang; Neale Jason R; Metry Kristin J; Doll Mark A; States J Christopher; Pierce William M; Hein David W
2-Amino-3,8-dimethylimidazo-[4,5-f]quinoxaline-induced DNA adduct formation and mutagenesis in DNA repair-deficient Chinese hamster ovary cells expressing human cytochrome P4501A1 and rapid or slow acetylator N-acetyltransferase 2.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(7):1503-9.
2007: Metry Kristin J; Zhao Shuang; Neale Jason R; Doll Mark A; States J Christopher; McGregor W Glenn; Pierce William M; Hein David W
2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine-induced DNA adducts and genotoxicity in chinese hamster ovary (CHO) cells expressing human CYP1A2 and rapid or slow acetylator N-acetyltransferase 2.
Molecular carcinogenesis 2007;46(7):553-63.
2007: Walraven Jason M; Trent John O; Hein David W
Computational and experimental analyses of mammalian arylamine N-acetyltransferase structure and function.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(6):1001-7.
2007: Husain Anwar; Zhang Xiaoyan; Doll Mark A; States J Christopher; Barker David F; Hein David W
Identification of N-acetyltransferase 2 (NAT2) transcription start sites and quantitation of NAT2-specific mRNA in human tissues.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(5):721-7.
2007: Lubin Jay H; Kogevinas Manolis; Silverman Debra; Malats Núria; Garcia-Closas Montserrat; Tardón Adonina; Hein David W; Garcia-Closas Reina; Serra Consol; Dosemeci Mustafa; Carrato Alfredo; Rothman Nathaniel
Evidence for an intensity-dependent interaction of NAT2 acetylation genotype and cigarette smoking in the Spanish Bladder Cancer Study.
International journal of epidemiology 2007;36(1):236-41.
2007: Rothman Nathaniel; Garcia-Closas Montserrat; Hein David W
Commentary: Reflections on G. M. Lower and colleagues' 1979 study associating slow acetylator phenotype with urinary bladder cancer: meta-analysis, historical refinements of the hypothesis, and lessons learned.
International journal of epidemiology 2007;36(1):23-8.
2007: Zang Yu; Zhao Shuang; Doll Mark A; Christopher States J; Hein David W
Functional characterization of the A411T (L137F) and G364A (D122N) genetic polymorphisms in human N-acetyltransferase 2.
Pharmacogenetics and genomics 2007;17(1):37-45.
2007: Mahid Suhal S; Colliver Daniel W; Crawford Nigel P S; Martini Benjamin D; Doll Mark A; Hein David W; Cobbs Gary A; Petras Robert E; Galandiuk Susan
Characterization of N-acetyltransferase 1 and 2 polymorphisms and haplotype analysis for inflammatory bowel disease and sporadic colorectal carcinoma.
BMC medical genetics 2007;8():28.
2006: Loehle Jennifer A; Cornish Valerie; Wakefield Larissa; Doll Mark A; Neale Jason R; Zang Yu; Sim Edith; Hein David W
N-acetyltransferase (Nat) 1 and 2 expression in Nat2 knockout mice.
The Journal of pharmacology and experimental therapeutics 2006;319(2):724-8.
2006: Walraven Jason M; Doll Mark A; Hein David W
Identification and characterization of functional rat arylamine N-acetyltransferase 3: comparisons with rat arylamine N-acetyltransferases 1 and 2.
The Journal of pharmacology and experimental therapeutics 2006;319(1):369-75.
2006: Moslehi Roxana; Chatterjee Nilanjan; Church Timothy R; Chen Jinbo; Yeager Meredith; Weissfeld Joel; Hein David W; Hayes Richard B
Cigarette smoking, N-acetyltransferase genes and the risk of advanced colorectal adenoma.
Pharmacogenomics 2006;7(6):819-29.
2006: Bhaiya Payal; Roychowdhury Sanjoy; Vyas Piyush M; Doll Mark A; Hein David W; Svensson Craig K
Bioactivation, protein haptenation, and toxicity of sulfamethoxazole and dapsone in normal human dermal fibroblasts.
Toxicology and applied pharmacology 2006;215(2):158-67.
2006: Hein David W; Fretland Adrian J; Doll Mark A
Effects of single nucleotide polymorphisms in human N-acetyltransferase 2 on metabolic activation (O-acetylation) of heterocyclic amine carcinogens.
International journal of cancer. Journal international du cancer 2006;119(5):1208-11.
2006: Morton Lindsay M; Schenk Maryjean; Hein David W; Davis Scott; Zahm Shelia Hoar; Cozen Wendy; Cerhan James R; Hartge Patricia; Welch Robert; Chanock Stephen J; Rothman Nathaniel; Wang Sophia S
Genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2) and risk of non-Hodgkin lymphoma.
Pharmacogenetics and genomics 2006;16(8):537-45.
2006: Barker David F; Husain Anwar; Neale Jason R; Martini Benjamin D; Zhang Xiaoyan; Doll Mark A; States J Christopher; Hein David W
Functional properties of an alternative, tissue-specific promoter for human arylamine N-acetyltransferase 1.
Pharmacogenetics and genomics 2006;16(7):515-25.
2006: Zhu Yusheng; Hein David W; Doll Mark A; Reynolds Kristen K; Abudu Ntei; Valdes Roland; Linder Mark W
Simultaneous determination of 7 N-acetyltransferase-2 single-nucleotide variations by allele-specific primer extension assay.
Clinical chemistry 2006;52(6):1033-9.
2006: Hein David W; Doll Mark A; Nerland Donald E; Fretland Adrian J
Tissue distribution of N-acetyltransferase 1 and 2 catalyzing the N-acetylation of 4-aminobiphenyl and O-acetylation of N-hydroxy-4-aminobiphenyl in the congenic rapid and slow acetylator Syrian hamster.
Molecular carcinogenesis 2006;45(4):230-8.
2006: Hein D W
N-acetyltransferase 2 genetic polymorphism: effects of carcinogen and haplotype on urinary bladder cancer risk.
Oncogene 2006;25(11):1649-58.
2006: Zhang Xiaoyan; Lambert Jason C; Doll Mark A; Walraven Jason M; Arteel Gavin E; Hein David W
4,4'-methylenedianiline-induced hepatotoxicity is modified by N-acetyltransferase 2 (NAT2) acetylator polymorphism in the rat.
The Journal of pharmacology and experimental therapeutics 2006;316(1):289-94.
2006: Li Donghui; Jiao Li; Li Yanan; Doll Mark A; Hein David W; Bondy Melissa L; Evans Douglas B; Wolff Robert A; Lenzi Renato; Pisters Peter W; Abbruzzese James L; Hassan Manal M
Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancer.
Carcinogenesis 2006;27(1):103-11.
2006: Martin Robert C G; Ahn Jiyoung; Nowell Susan A; Hein David W; Doll Mark A; Martini Benjamin D; Ambrosone Christine B
Association between manganese superoxide dismutase promoter gene polymorphism and breast cancer survival.
Breast cancer research : BCR 2006;8(4):R45.
2005: García-Closas Montserrat; Malats Núria; Silverman Debra; Dosemeci Mustafa; Kogevinas Manolis; Hein David W; Tardón Adonina; Serra Consol; Carrato Alfredo; García-Closas Reina; Lloreta Josep; Castaño-Vinyals Gemma; Yeager Meredith; Welch Robert; Chanock Stephen; Chatterjee Nilanjan; Wacholder Sholom; Samanic Claudine; Torà Montserrat; Fernández Francisco; Real Francisco X; Rothman Nathaniel
NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses.
Lancet 2005;366(9486):649-59.
2005: Martin Robert C G; Lan Qing; Hughes Kalista; Doll Mark A; Martini Benjamin D; Lissowska Jolanta; Zatonski Witold; Rothman Nathaniel; Hein David W
No apparent association between genetic polymorphisms (-102 C>T) and (-9 T>C) in the human manganese superoxide dismutase gene and gastric cancer(1).
The Journal of surgical research 2005;124(1):92-7.
2004: Martin Robert C G; Hughes Kalista; Doll Mark A; Lan Qing; Martini Benjamin D; Lissowska Jolanta; Rothman Nathaniel; Hein David W
Method for determination of (-102C>T) single nucleotide polymorphism in the human manganese superoxide dismutase promoter.
BMC genetics 2004;5(1):33.
2004: Zang Yu; Zhao Shuang; Doll Mark A; States J Christopher; Hein David W
The T341C (Ile114Thr) polymorphism of N-acetyltransferase 2 yields slow acetylator phenotype by enhanced protein degradation.
Pharmacogenetics 2004;14(11):717-23.
2004: Guo Luping; Richardson Katharine S; Tucker Lindsay M; Doll Mark A; Hein David W; Arteel Gavin E
Role of the renin-angiotensin system in hepatic ischemia reperfusion injury in rats.
Hepatology (Baltimore, Md.) 2004;40(3):583-9.
2004: Deitz Anne C; Rothman Nathanial; Rebbeck Timothy R; Hayes Richard B; Chow Wong-Ho; Zheng Wei; Hein David W; García-Closas Montserrat
Impact of misclassification in genotype-exposure interaction studies: example of N-acetyltransferase 2 (NAT2), smoking, and bladder cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004;13(9):1543-6.
2004: Husain Anwar; Barker David F; States J Christopher; Doll Mark A; Hein David W
Identification of the major promoter and non-coding exons of the human arylamine N-acetyltransferase 1 gene (NAT1).
Pharmacogenetics 2004;14(7):397-406.
2004: Palmer Larry I; Martin Robert C G; Hein David W
Chemopreventive drug treatment in subjects with genetic predisposition to cancer: prescriber liability and healthcare disparities.
Pharmacogenomics 2004;5(3):319-29.
2003: Fretland Adrian J; Devanaboyina Uday S; Doll Mark A; Zhao Shuang; Xiao Gong H; Hein David W
Metabolic activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Syrian hamsters congenic at the N-acetyltransferase 2 (NAT2) locus.
Toxicological sciences : an official journal of the Society of Toxicology 2003;74(2):253-9.
2003: Lan Qing; Rothman Nathaniel; Chow Wong-Ho; Lissowska Jolanta; Doll Mark A; Xiao Gong H; Zatonski Witold; Hein David W
No apparent association between NAT1 and NAT2 genotypes and risk of stomach cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2003;12(4):384-6.
2003: Hein David W; Doll Mark A; Xiao Gong H; Feng Yi
Prostate expression of N-acetyltransferase 1 (NAT1) and 2 (NAT2) in rapid and slow acetylator congenic Syrian hamster.
Pharmacogenetics 2003;13(3):159-67.
2002: Hein David W
Molecular genetics and function of NAT1 and NAT2: role in aromatic amine metabolism and carcinogenesis.
Mutation research 2002;506-507():65-77.
2002: Zhu Yuanqi; Doll Mark A; Hein David W
Functional genomics of C190T single nucleotide polymorphism in human N-acetyltransferase 2.
Biological chemistry 2002;383(6):983-7.
2002: O'Neil William M; MacArthur Rodger D; Farrough Marti J; Doll Mark A; Fretland Adrian J; Hein David W; Crane Lawrence R; Svensson Craig K
Acetylator phenotype and genotype in HIV-infected patients with and without sulfonamide hypersensitivity.
Journal of clinical pharmacology 2002;42(6):613-9.
2002: Ishibe Naoko; Sinha Rashmi; Hein David W; Kulldorff Martin; Strickland Paul; Fretland Adrian J; Chow Wong-Ho; Kadlubar Fred F; Lang Nicholas P; Rothman Nathaniel
Genetic polymorphisms in heterocyclic amine metabolism and risk of colorectal adenomas.
Pharmacogenetics 2002;12(2):145-50.
2002: Doll Mark A; Hein David W
Rapid genotype method to distinguish frequent and/or functional polymorphisms in human N-acetyltransferase-1.
Analytical biochemistry 2002;301(2):328-32.
2002: Hein David W; Leff Matthew A; Ishibe Naoko; Sinha Rashmi; Frazier Harold A; Doll Mark A; Xiao Gong H; Weinrich Martin C; Caporaso Neil E
Association of prostate cancer with rapid N-acetyltransferase 1 (NAT1*10) in combination with slow N-acetyltransferase 2 acetylator genotypes in a pilot case-control study.
Environmental and molecular mutagenesis 2002;40(3):161-7.
2002: Fretland Adrian J; Doll Mark A; Zhu Yuanqi; Smith Leo; Leff Matthew A; Hein David W
Effect of nucleotide substitutions in N-acetyltransferase-1 on N-acetylation (deactivation) and O-acetylation (activation) of arylamine carcinogens: implications for cancer predisposition.
Cancer detection and prevention 2002;26(1):10-4.
2001: Lan Q; Chow W H; Lissowska J; Hein D W; Buetow K; Engel L S; Ji B; Zatonski W; Rothman N
Glutathione S-transferase genotypes and stomach cancer in a population-based case-control study in Warsaw, Poland.
Pharmacogenetics 2001;11(8):655-61.
2001: Fretland A J; Doll M A; Leff M A; Hein D W
Functional characterization of nucleotide polymorphisms in the coding region of N-acetyltransferase 1.
Pharmacogenetics 2001;11(6):511-20.
2001: Fretland A J; Leff M A; Doll M A; Hein D W
Functional characterization of human N-acetyltransferase 2 (NAT2) single nucleotide polymorphisms.
Pharmacogenetics 2001;11(3):207-15.
2001: Fretland A J; Devanaboyina U S; Feng Y; Leff M A; Xiao G H; Webb S J; Hein D W
Oral administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) yields PhIP-DNA adducts but not tumors in male Syrian hamsters congenic at the N-acetyltransferase 2 (NAT2) locus.
Toxicological sciences : an official journal of the Society of Toxicology 2001;59(2):226-30.
2001: Doll M A; Hein D W
Comprehensive human NAT2 genotype method using single nucleotide polymorphism-specific polymerase chain reaction primers and fluorogenic probes.
Analytical biochemistry 2001;288(1):106-8.
2001: Fretland A J; Devanaboyina U S; Nangju N A; Leff M A; Xiao G H; Webb S J; Doll M A; Hein D W
DNA adduct levels and absence of tumors in female rapid and slow acetylator congenic hamsters administered the rat mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine.
Journal of biochemical and molecular toxicology 2001;15(1):26-33.
2000: Hein D W; McQueen C A; Grant D M; Goodfellow G H; Kadlubar F F; Weber W W
Pharmacogenetics of the arylamine N-acetyltransferases: a symposium in honor of Wendell W. Weber.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(12):1425-32.
2000: Deitz A C; Zheng W; Leff M A; Gross M; Wen W Q; Doll M A; Xiao G H; Folsom A R; Hein D W
N-Acetyltransferase-2 genetic polymorphism, well-done meat intake, and breast cancer risk among postmenopausal women.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2000;9(9):905-10.
2000: Steffensen I L; Fretland A J; Paulsen J E; Feng Y; Eide T J; Devanaboyina U S; Hein D W; Alexander J
DNA adduct levels and intestinal lesions in congenic rapid and slow acetylator syrian hamsters admi food mutagens 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) or 2-amino-3-methylimidazo[4,5-f]quinoline (IQ).
Pharmacology & toxicology 2000;86(6):257-63.
2000: Reilly T P; Lash L H; Doll M A; Hein D W; Woster P M; Svensson C K
A role for bioactivation and covalent binding within epidermal keratinocytes in sulfonamide-induced cutaneous drug reactions.
The Journal of investigative dermatology 2000;114(6):1164-73.
2000: Purewal M; Velasco M; Fretland A J; Hein D W; Wargovich M J
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine induces a higher number of aberrant crypt foci in Fischer 344 (rapid) than in Wistar Kyoto (slow) acetylator inbred rats.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2000;9(5):529-32.
2000: O'Neil W M; Drobitch R K; MacArthur R D; Farrough M J; Doll M A; Fretland A J; Hein D W; Crane L R; Svensson C K
Acetylator phenotype and genotype in patients infected with HIV: discordance between methods for phenotype determination and genotype.
Pharmacogenetics 2000;10(2):171-82.
2000: Hein D W
N-Acetyltransferase genetics and their role in predisposition to aromatic and heterocyclic amine-induced carcinogenesis.
Toxicology letters 2000;112-113():349-56.
2000: Purewal M; Fretland A J; Schut H A; Hein D W; Wargovich M J
Association between acetylator genotype and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) DNA adduct formation in colon and prostate of inbred Fischer 344 and Wistar Kyoto rats.
Cancer letters 2000;149(1-2):53-60.
2000: Hein D W; Doll M A; Fretland A J; Leff M A; Webb S J; Xiao G H; Devanaboyina U S; Nangju N A; Feng Y
Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2000;9(1):29-42.
1999: Leff M A; Fretland A J; Doll M A; Hein D W
Novel human N-acetyltransferase 2 alleles that differ in mechanism for slow acetylator phenotype.
The Journal of biological chemistry 1999;274(49):34519-22.
1999: Leff M A; Epstein P N; Doll M A; Fretland A J; Devanaboyina U S; Rustan T D; Hein D W
Prostate-specific human N-acetyltransferase 2 (NAT2) expression in the mouse.
The Journal of pharmacology and experimental therapeutics 1999;290(1):182-7.
1999: Feng Y; Finley J W; Davis C D; Becker W K; Fretland A J; Hein D W
Dietary selenium reduces the formation of aberrant crypts in rats administered 3,2'-dimethyl-4-aminobiphenyl.
Toxicology and applied pharmacology 1999;157(1):36-42.
1999: Jiang W; Feng Y; Hein D W
Higher DNA adduct levels in urinary bladder and prostate of slow acetylator inbred rats administered 3,2'-dimethyl-4-aminobiphenyl.
Toxicology and applied pharmacology 1999;156(3):187-94.
1999: Zheng W; Deitz A C; Campbell D R; Wen W Q; Cerhan J R; Sellers T A; Folsom A R; Hein D W
N-acetyltransferase 1 genetic polymorphism, cigarette smoking, well-done meat intake, and breast cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1999;8(3):233-9.
1999: Hulla J E; Miller M S; Taylor J A; Hein D W; Furlong C E; Omiecinski C J; Kunkel T A
Symposium overview: the role of genetic polymorphism and repair deficiencies in environmental disease.
Toxicological sciences : an official journal of the Society of Toxicology 1999;47(2):135-43.
1999: Davis C D; Feng Y; Hein D W; Finley J W
The chemical form of selenium influences 3,2'-dimethyl-4-aminobiphenyl-DNA adduct formation in rat colon.
The Journal of nutrition 1999;129(1):63-9.
1998: Feng Y; Rustan T D; Fretland A J; Cooley A M; Lee K J; Becker W K; Hein D W
A rapid and sensitive method for detection of urinary bladder tumors in rodents.
Proceedings of the Western Pharmacology Society 1998;41():11-3.
1997: Deitz A C; Doll M A; Hein D W
A restriction fragment length polymorphism assay that differentiates human N-acetyltransferase-1 (NAT1) alleles.
Analytical biochemistry 1997;253(2):219-24.
1997: Feng Y; Fretland A J; Rustan T D; Jiang W; Becker W K; Hein D W
Higher frequency of aberrant crypt foci in rapid than slow acetylator inbred rats administered the colon carcinogen 3,2'-dimethyl-4-aminobiphenyl.
Toxicology and applied pharmacology 1997;147(1):56-62.
1997: Hein D W; Doll M A; Fretland A J; Gray K; Deitz A C; Feng Y; Jiang W; Rustan T D; Satran S L; Wilkie T R
Rodent models of the human acetylation polymorphism: comparisons of recombinant acetyltransferases.
Mutation research 1997;376(1-2):101-6.
1997: Doll M A; Jiang W; Deitz A C; Rustan T D; Hein D W
Identification of a novel allele at the human NAT1 acetyltransferase locus.
Biochemical and biophysical research communications 1997;233(3):584-91.
1997: Fretland A J; Doll M A; Gray K; Feng Y; Hein D W
Cloning, sequencing, and recombinant expression of NAT1, NAT2, and NAT3 derived from the C3H/HeJ (rapid) and A/HeJ (slow) acetylator inbred mouse: functional characterization of the activation and deactivation of aromatic amine carcinogens.
Toxicology and applied pharmacology 1997;142(2):360-6.
1997: Fretland A J; Feng Y; Hein D W
DNA adduct levels in rapid and slow acetylator inbred rats administered 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Proceedings of the Western Pharmacology Society 1997;40():9-12.
1997: Hein D W; Ferguson R J; Doll M A; Deitz A C
Recombinant expression and catalytic analysis of rapid and slow acetylator Syrian hamster chimeric NAT2 alleles.
Archives of toxicology 1997;71(5):306-13.
1996: Feng Y; Jiang W; Hein D W
2-Aminofluorene-DNA adduct levels in tumor-target and nontarget organs of rapid and slow acetylator Syrian hamsters congenic at the NAT2 locus.
Toxicology and applied pharmacology 1996;141(1):248-55.
1996: Feng Y; Jiang W; Deitz A C; Hein D W
3,2'-Dimethyl-4-aminobiphenyl-DNA adduct formation in tumor target and nontarget organs of rapid and slow acetylator Syrian hamsters cogenic at the NAT2 locus.
Toxicology and applied pharmacology 1996;140(2):315-21.
1996: Zenser T V; Lakshmi V M; Rustan T D; Doll M A; Deitz A C; Davis B B; Hein D W
Human N-acetylation of benzidine: role of NAT1 and NAT2.
Cancer research 1996;56(17):3941-7.
1996: Ferguson R J; Doll M A; Rustan T D; Hein D W
Cloning, expression, and functional characterization of rapid and slow acetylator polymorphic N-acetyl-transferase encoding genes of the Syrian hamster.
Pharmacogenetics 1996;6(1):55-66.
1996: Feng Y; Wagner R J; Fretland A J; Becker W K; Cooley A M; Pretlow T P; Lee K J; Hein D W
Acetylator genotype (NAT2)-dependent formation of aberrant crypts in congenic Syrian hamsters administered 3,2'-dimethyl-4-aminobiphenyl.
Cancer research 1996;56(3):527-31.
1995: Doll M A; Fretland A J; Deitz A C; Hein D W
Determination of human NAT2 acetylator genotype by restriction fragment-length polymorphism and allele-specific amplification.
Analytical biochemistry 1995;231(2):413-20.
1995: Doll M A; Hein D W
Cloning, sequencing and expression of NAT1 and NAT2 encoding genes from rapid and slow acetylator inbred rats.
Pharmacogenetics 1995;5(4):247-51.
1995: Hein D W; Doll M A; Rustan T D; Ferguson R J
Metabolic activation of N-hydroxyarylamines and N-hydroxyarylamides by 16 recombinant human NAT2 allozymes: effects of 7 specific NAT2 nucleic acid substitutions.
Cancer research 1995;55(16):3531-6.
1995: Hein D W; Doll M A; Ferguson R J
Metabolic activation of carcinogenic arylamines by rapid acetylator, slow acetylator, and chimeric recombinant Syrian hamster NAT2 allozymes.
Proceedings of the Western Pharmacology Society 1995;38():59-62.
1994: Hein D W; Ferguson R J; Doll M A; Rustan T D; Gray K
Molecular genetics of human polymorphic N-acetyltransferase: enzymatic analysis of 15 recombinant wild-type, mutant, and chimeric NAT2 allozymes.
Human molecular genetics 1994;3(5):729-34.
1994: Ferguson R J; Doll M A; Rustan T D; Gray K; Hein D W
Cloning, expression, and functional characterization of two mutant (NAT2(191) and NAT2(341/803)) and wild-type human polymorphic N-acetyltransferase (NAT2) alleles.
Drug metabolism and disposition: the biological fate of chemicals 1994;22(3):371-6.
1994: Ferguson R J; Doll M A; Rustan T D; Baumstark B R; Hein D W
Syrian hamster monomorphic N-acetyltransferase (NAT1) alleles: amplification, cloning, sequencing, and expression in E. coli.
Pharmacogenetics 1994;4(2):82-90.
1994: Ferguson R J; Doll M A; Baumstark B R; Hein D W
Polymorphic arylamine N-acetyltransferase encoding gene (NAT2) from homozygous rapid and slow acetylator congenic Syrian hamsters.
Gene 1994;140(2):247-9.
1994: Hein D W; Doll M A; Rustan T D; Gray K; Ferguson R J; Feng Y
Construction of Syrian hamster lines congenic at the polymorphic acetyltransferase locus (NAT2): acetylator genotype-dependent N- and O-acetylation of arylamine carcinogens.
Toxicology and applied pharmacology 1994;124(1):16-24.
1994: Feng Y; Rustan T D; Ferguson R J; Doll M A; Hein D W
Acetylator genotype-dependent formation of 2-aminofluorene-hemoglobin adducts in rapid and slow acetylator Syrian hamsters congenic at the NAT2 locus.
Toxicology and applied pharmacology 1994;124(1):10-5.
1994: Hein D W; Rustan T D; Ferguson R J; Doll M A; Gray K
Metabolic activation of aromatic and heterocyclic N-hydroxyarylamines by wild-type and mutant recombinant human NAT1 and NAT2 acetyltransferases.
Archives of toxicology 1994;68(2):129-33.
1993: Hein D W; Doll M A; Rustan T D; Gray K; Feng Y; Ferguson R J; Grant D M
Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases.
Carcinogenesis 1993;14(8):1633-8.
1993: Hein D W; Doll M A; Gray K; Rustan T D; Ferguson R J
Metabolic activation of N-hydroxy-2-aminofluorene and N-hydroxy-2-acetylaminofluorene by monomorphic N-acetyltransferase (NAT1) and polymorphic N-acetyltransferase (NAT2) in colon cytosols of Syrian hamsters congenic at the NAT2 locus.
Cancer research 1993;53(3):509-14.
1993: Rodriguez J W; Kirlin W G; Ferguson R J; Doll M A; Gray K; Rustan T D; Lee M E; Kemp K; Urso P; Hein D W
Human acetylator genotype: relationship to colorectal cancer incidence and arylamine N-acetyltransferase expression in colon cytosol.
Archives of toxicology 1993;67(7):445-52.
1992: Hein D W; Rustan T D; Doll M A; Bucher K D; Ferguson R J; Feng Y; Furman E J; Gray K
Acetyltransferases and susceptibility to chemicals.
Toxicology letters 1992;64-65 Spec No():123-30.
1992: Flammang T J; Yerokun T; Bryant M S; Couch L H; Kirlin W G; Lee K J; Ogolla F; Ferguson R J; Talaska G; Hein D W
Hemoglobin adduct and hepatic- and urinary bladder-DNA adduct levels in rapid and slow acetylator Syrian inbred hamsters administered 2-aminofluorene.
The Journal of pharmacology and experimental therapeutics 1992;260(2):865-71.
1992: Hein D W; Rustan T D; Martin W J; Bucher K D; Miller L S; Furman E J
Acetylator genotype-dependent N-acetylation of arylamines in vivo and in vitro by hepatic and extrahepatic organ cytosols of Syrian hamsters congenic at the polymorphic acetyltransferase locus.
Archives of toxicology 1992;66(2):112-7.
1991: Hein D W; Rustan T D; Bucher K D; Miller L S
Polymorphic and monomorphic expression of arylamine carcinogen N-acetyltransferase isozymes in tumor target organ cytosols of Syrian hamsters congenic at the polymorphic acetyltransferase locus.
The Journal of pharmacology and experimental therapeutics 1991;259(2):699-704.
1991: Hein D W; Rustan T D; Bucher K D; Martin W J; Furman E J
Acetylator phenotype-dependent and -independent expression of arylamine N-acetyltransferase isozymes in rapid and slow acetylator inbred rat liver.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(5):933-7.
1991: Hein D W; Rustan T D; Bucher K D; Furman E J; Martin W J
Extrahepatic expression of the N-acetylation polymorphism toward arylamine carcinogens in tumor target organs of an inbred rat model.
The Journal of pharmacology and experimental therapeutics 1991;258(1):232-6.
1991: Kirlin W G; Ogolla F; Andrews A F; Trinidad A; Ferguson R J; Yerokun T; Mpezo M; Hein D W
Acetylator genotype-dependent expression of arylamine N-acetyltransferase in human colon cytosol from non-cancer and colorectal cancer patients.
Cancer research 1991;51(2):549-55.
1991: Hein D W
Genetic regulation of N-acetyltransferase in target organs of arylamine tumors: homologous expression in human and hamster bladder and colon.
Proceedings of the Western Pharmacology Society 1991;34():55-60.
1990: Trinidad A; Hein D W; Rustan T D; Ferguson R J; Miller L S; Bucher K D; Kirlin W G; Ogolla F; Andrews A F
Purification of hepatic polymorphic arylamine N-acetyltransferase from homozygous rapid acetylator inbred hamster: identity with polymorphic N-hydroxyarylamine-O-acetyltransferase.
Cancer research 1990;50(24):7942-9.
1990: Ogolla F; Ferguson R J; Kirlin W G; Trinidad A; Andrews A F; Mpezo M; Hein D W
Acetylator genotype-dependent expression of arylamine N-acetyltransferase and N-hydroxyarylamine O-acetyltransferase in Syrian inbred hamster intestine and colon. Identity with the hepatic acetylation polymorphism.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(5):680-5.
1990: Yerokun T; Hein D W; Ferguson R J; Ogolla F; Heflich R H; Minor T Y; Trinidad A; Kirlin W G; Andrews A F
Relationship of Syrian inbred hamster acetylator genotype to the mutagenic activation of 2-aminofluorene.
Mutagenesis 1990;5(3):233-9.
1990: Hein D W; Trinidad A; Yerokun T; Kirlin W G; Ogolla F; Ferguson R J; Andrews A F
Genetic regulation of acetyltransferases in the Syrian inbred hamster: a model for man.
Progress in clinical and biological research 1990;340B():115-24.
1989: Kirlin W G; Trinidad A; Yerokun T; Ogolla F; Ferguson R J; Andrews A F; Brady P K; Hein D W
Polymorphic expression of acetyl coenzyme A-dependent arylamine N-acetyltransferase and acetyl coenzyme A-dependent O-acetyltransferase-mediated activation of N-hydroxyarylamines by human bladder cytosol.
Cancer research 1989;49(9):2448-54.
1989: Trinidad A; Kirlin W G; Ogolla F; Andrews A F; Yerokun T; Ferguson R J; Brady P K; Hein D W
Kinetic characterization of acetylator genotype-dependent and -independent N-acetyltransferase isozymes in homozygous rapid and slow acetylator inbred hamster liver cytosol.
Drug metabolism and disposition: the biological fate of chemicals 1989;17(3):238-47.
1989: Yerokun T; Kirlin W G; Trinidad A; Ferguson R J; Ogolla F; Andrews A F; Brady P K; Hein D W
Identification and kinetic characterization of acetylator genotype-dependent and -independent arylamine carcinogen N-acetyltransferases in hamster bladder cytosol.
Drug metabolism and disposition: the biological fate of chemicals 1989;17(3):231-7.
1988: Hein D W; Trinidad A; Yerokun T; Ferguson R J; Kirlin W G; Weber W W
Genetic control of acetyl coenzyme A-dependent arylamine N-acetyltransferase, hydrazine N-acetyltransferase, and N-hydroxy-arylamine O-acetyltransferase enzymes in C57BL/6J, A/J, AC57F1, and the rapid and slow acetylator A.B6 and B6.A congenic inbred mouse.
Drug metabolism and disposition: the biological fate of chemicals 1988;16(3):341-7.
1987: Hein D W; Flammang T J; Kirlin W G; Trinidad A; Ogolla F
Acetylator genotype-dependent metabolic activation of carcinogenic N-hydroxyarylamines by S-acetyl coenzyme A-dependent enzymes of inbred hamster tissue cytosols: relationship to arylamine N-acetyltransferase.
Carcinogenesis 1987;8(12):1767-74.
1987: Hein D W; Kirlin W G; Yerokun T; Trinidad A; Ogolla F
Inheritance of acetylator genotype-dependent arylamine N-acetyltransferase in hamster bladder cytosol.
Carcinogenesis 1987;8(5):647-52.
1987: Hein D W; Kirlin W G; Ogolla F; Trinidad A
Extrahepatic expression of N-acetylator genotype in the inbred hamster.
Drug metabolism and disposition: the biological fate of chemicals 1987;15(1):68-73.
1986: Hein D W; Kirlin W G; Ferguson R J; Thompson L K; Ogolla F
Identification and inheritance of inbred hamster N-acetyltransferase isozymes in peripheral blood.
The Journal of pharmacology and experimental therapeutics 1986;239(3):823-8.
1986: Hein D W; Kirlin W G; Ogolla F; Trinidad A; Thompson L K; Ferguson R J
The role of acetylator genotype on hepatic and extrahepatic acetylation, deacetylation, and sulfation of 2-aminofluorene, 2-acetylaminofluorene, and N-hydroxy-2-acetylaminofluorene in the inbred hamster.
Drug metabolism and disposition: the biological fate of chemicals 1986;14(5):566-73.
1985: Hein D W; Kirlin W G; Ferguson R J; Weber W W
Biochemical investigation of the basis for the genetic N-acetylation polymorphism in the inbred hamster.
The Journal of pharmacology and experimental therapeutics 1985;234(2):358-64.
1985: Hein D W; Kirlin W G; Ferguson R J; Weber W W
Inheritance of liver N-acetyltransferase activity in the rapid and slow acetylator inbred hamster.
The Journal of pharmacology and experimental therapeutics 1985;233(3):584-7.

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