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Jeremy Richman

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P Douglas Boatman; Ester Carballo-Jane; Luzelena Caro; Ruoping Chen; Martin C Cherrier; Steven L Colletti; Daniel T Connolly; Josee Cote; Milton Hammond; Benjamin R Johnson; Jae-Kyu Jung; Michelle Kasem; Jens Knudsen; Eseng Lai; Brett Lauring; Wen-Lin Luo; Carleton R Sage; Thomas O Schrader; Graeme Semple; Philip J Skinner; Andrew K P Taggart; James R Tata; John Wagner; M Gerard Waters; Peter J Webb; Jerry Xu; Jeremy G Richman
(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans.
P Douglas Boatman; Thomas O Schrader; Michelle Kasem; Benjamin R Johnson; Philip J Skinner; Jae-Kyu Jung; Jerry Xu; Martin C Cherrier; Peter J Webb; Graeme Semple; Carleton R Sage; Jens Knudsen; Ruoping Chen; Andrew K P Taggart; Ester Carballo-Jane; Jeremy G Richman
Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a).
Philip J Skinner; Peter J Webb; Carleton R Sage; T Huong Dang; Cameron C Pride; Ruoping Chen; Susan Y Tamura; Jeremy G Richman; Daniel T Connolly; Graeme Semple
5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b.

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All Publications

2012: P Douglas Boatman; Ester Carballo-Jane; Luzelena Caro; Ruoping Chen; Martin C Cherrier; Steven L Colletti; Daniel T Connolly; Josee Cote; Milton Hammond; Benjamin R Johnson; Jae-Kyu Jung; Michelle Kasem; Jens Knudsen; Eseng Lai; Brett Lauring; Wen-Lin Luo; Carleton R Sage; Thomas O Schrader; Graeme Semple; Philip J Skinner; Andrew K P Taggart; James R Tata; John Wagner; M Gerard Waters; Peter J Webb; Jerry Xu; Jeremy G Richman
(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans.
Journal of medicinal chemistry 2012;55(8):3644-66.
2010: P Douglas Boatman; Thomas O Schrader; Michelle Kasem; Benjamin R Johnson; Philip J Skinner; Jae-Kyu Jung; Jerry Xu; Martin C Cherrier; Peter J Webb; Graeme Semple; Carleton R Sage; Jens Knudsen; Ruoping Chen; Andrew K P Taggart; Ester Carballo-Jane; Jeremy G Richman
Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a).
Bioorganic & medicinal chemistry letters 2010;20(9):2797-800.
2009: Philip J Skinner; Peter J Webb; Carleton R Sage; T Huong Dang; Cameron C Pride; Ruoping Chen; Susan Y Tamura; Jeremy G Richman; Daniel T Connolly; Graeme Semple
5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b.
Bioorganic & medicinal chemistry letters 2009;19(15):4207-9.
2008: Graeme Semple; Philip J Skinner; Tawfik Gharbaoui; Young-Jun Shin; Jae-Kyu Jung; Martin C Cherrier; Peter J Webb; Susan Y Tamura; P Douglas Boatman; Carleton R Sage; Thomas O Schrader; Ruoping Chen; Steven L Colletti; James R Tata; M Gerard Waters; Kang Cheng; Andrew K Taggart; Tian-Quan Cai; Ester Carballo-Jane; Dominic P Behan; Daniel T Connolly; Jeremy G Richman
3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): a partial agonist of the nicotinic acid receptor, G-protein coupled receptor 109a, with antilipolytic but no vasodilatory activity in mice.
Journal of medicinal chemistry 2008;51(16):5101-8.
2007: Philip J Skinner; Martin C Cherrier; Peter J Webb; Carleton R Sage; Huong T Dang; Cameron C Pride; Ruoping Chen; Susan Y Tamura; Jeremy G Richman; Daniel T Connolly; Graeme Semple
3-Nitro-4-amino benzoic acids and 6-amino nicotinic acids are highly selective agonists of GPR109b.
Bioorganic & medicinal chemistry letters 2007;17(23):6619-22.
2007: Ester Carballo-Jane; Lynn S Gerckens; Silvi Luell; Allison S Parlapiano; Michael Wolff; Steven L Colletti; James R Tata; Andrew K P Taggart; M Gerard Waters; Jeremy G Richman; Margaret E McCann; Michael J Forrest
Comparison of rat and dog models of vasodilatation and lipolysis for the calculation of a therapeutic index for GPR109A agonists.
Journal of pharmacological and toxicological methods 2007;56(3):308-16.
2007: Philip J Skinner; Martin C Cherrier; Peter J Webb; Young-Jun Shin; Tawfik Gharbaoui; Andrew Lindstrom; Vu Hong; Susan Y Tamura; Huong T Dang; Cameron C Pride; Ruoping Chen; Jeremy G Richman; Daniel T Connolly; Graeme Semple
Fluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a.
Bioorganic & medicinal chemistry letters 2007;17(20):5620-3.
2007: Tawfik Gharbaoui; Philip J Skinner; Young-Jun Shin; Claudia Averbuj; Jae-Kyu Jung; Benjamin R Johnson; Tracy Duong; Marc Decaire; Jane Uy; Martin C Cherrier; Peter J Webb; Susan Y Tamura; Ning Zou; Nathalie Rodriguez; P Douglas Boatman; Carleton R Sage; Andrew Lindstrom; Jerry Xu; Thomas O Schrader; Brian M Smith; Ruoping Chen; Jeremy G Richman; Daniel T Connolly; Steven L Colletti; James R Tata; Graeme Semple
Agonist lead identification for the high affinity niacin receptor GPR109a.
Bioorganic & medicinal chemistry letters 2007;17(17):4914-9.
2007: Graeme Semple; P Douglas Boatman; Jeremy G Richman
Recent progress in the discovery of niacin receptor agonists.
Current opinion in drug discovery & development 2007;10(4):452-9.
2007: Jeremy G Richman; Martha Kanemitsu-Parks; Ibragim Gaidarov; Jill S Cameron; Peter Griffin; Hong Zheng; Nuvia C Guerra; Linda Cham; Dominique Maciejewski-Lenoir; Dominic P Behan; Doug Boatman; Ruoping Chen; Philip J Skinner; Pricilla Ornelas; M Gerard Waters; Samuel D Wright; Graeme Semple; Daniel T Connolly
Nicotinic acid receptor agonists differentially activate downstream effectors.
The Journal of biological chemistry 2007;282(25):18028-36.
2007: Jae-Kyu Jung; Benjamin R Johnson; Tracy Duong; Marc Decaire; Jane Uy; Tawfik Gharbaoui; P Douglas Boatman; Carleton R Sage; Ruoping Chen; Jeremy G Richman; Daniel T Connolly; Graeme Semple
Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b.
Journal of medicinal chemistry 2007;50(7):1445-8.
2006: Dominique Maciejewski-Lenoir; Jeremy G Richman; Yaron Hakak; Ibragim Gaidarov; Dominic P Behan; Daniel T Connolly
Langerhans cells release prostaglandin D2 in response to nicotinic acid.
The Journal of investigative dermatology 2006;126(12):2637-46.
2006: Graeme Semple; Philip J Skinner; Martin C Cherrier; Peter J Webb; Carleton R Sage; Susan Y Tamura; Ruoping Chen; Jeremy G Richman; Daniel T Connolly
1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b.
Journal of medicinal chemistry 2006;49(4):1227-30.
2005: Andrew K P Taggart; Jukka Kero; Xiaodong Gan; Tian-Quan Cai; Kang Cheng; Marc Ippolito; Ning Ren; Rebecca Kaplan; Kenneth Wu; Tsuei-Ju Wu; Lan Jin; Chen Liaw; Ruoping Chen; Jeremy G Richman; Daniel Connolly; Stefan Offermanns; Samuel D Wright; M Gerard Waters
(D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G.
The Journal of biological chemistry 2005;280(29):26649-52.
2003: Amy C Porter; Samuel P S Svensson; W Daniel Stamer; Joseph J Bahl; Jeremy G Richman; John W Regan
Alpha-2 adrenergic receptors stimulate actin organization in developing fetal rat cardiac myocytes.
Life sciences 2003;72(13):1455-66.
2001: Jeremy G Richman; Ashley E Brady; Qin Wang; J L Hensel; Roger J Colbran; Lee E Limbird
Agonist-regulated Interaction between alpha2-adrenergic receptors and spinophilin.
The Journal of biological chemistry 2001;276(18):15003-8.
1999: L Prezeau; Jeremy G Richman; Stephen Wilton Edwards; Lee E Limbird
The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor subtypes.
The Journal of biological chemistry 1999;274(19):13462-9.
1998: Jeremy G Richman; John W Regan
Alpha 2-adrenergic receptors increase cell migration and decrease F-actin labeling in rat aortic smooth muscle cells.
The American journal of physiology 1998;274(3 Pt 1):C654-62.
1996: Samuel P S Svensson; T J Bailey; Amy C Porter; Jeremy G Richman; John W Regan
Heterologous expression of the cloned guinea pig alpha 2A, alpha 2B, and alpha 2C adrenoceptor subtypes. Radioligand binding and functional coupling to a CAMP-responsive reporter gene.
Biochemical pharmacology 1996;51(3):291-300.
1994: I Sora; Jeremy G Richman; G Santoro; Hongbing Wei; Y Wang; Todd W Vanderah; R Horvath; M Nguyen; Sue Waite; William R Roeske
The cloning and expression of a human creatine transporter.
Biochemical and biophysical research communications 1994;204(1):419-27.