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Sharad Purohit

Research Profile

Living Beings

Disorders

Type 1 Diabetes Mellitus

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Publications

TOP 3
Yulan Jin; Sharad Purohit; Xueqin Chen; Bing Yi; Jin-Xiong She
Over-expression of Stat5b confers protection against diabetes in the non-obese diabetic (NOD) mice via up-regulation of CD4(+)CD25(+) regulatory T cells.
Wenbo Zhi; Sharad Purohit; Colleen Carey; Meiyao Wang; Jin-Xiong She
Proteomic technologies for the discovery of type 1 diabetes biomarkers.
Junyan Han; Jixin Zhong; Wenzhong Wei; Ying Wang; Yafei Huang; Ping Yang; Sharad Purohit; Zheng Dong; Mong-Heng Wang; Jin-Xiong She; Feili Gong; David M Stern; Cong-Yi Wang
Extracellular high-mobility group box 1 acts as an innate immune mediator to enhance autoimmune progression and diabetes onset in NOD mice.

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All Publications

2012: Yulan Jin; Sharad Purohit; Xueqin Chen; Bing Yi; Jin-Xiong She
Over-expression of Stat5b confers protection against diabetes in the non-obese diabetic (NOD) mice via up-regulation of CD4(+)CD25(+) regulatory T cells.
Biochemical and biophysical research communications 2012;424(4):669-74.
2010: Wenbo Zhi; Sharad Purohit; Colleen Carey; Meiyao Wang; Jin-Xiong She
Proteomic technologies for the discovery of type 1 diabetes biomarkers.
Journal of diabetes science and technology 2010;4(4):993-1002.
2008: Junyan Han; Jixin Zhong; Wenzhong Wei; Ying Wang; Yafei Huang; Ping Yang; Sharad Purohit; Zheng Dong; Mong-Heng Wang; Jin-Xiong She; Feili Gong; David M Stern; Cong-Yi Wang
Extracellular high-mobility group box 1 acts as an innate immune mediator to enhance autoimmune progression and diabetes onset in NOD mice.
Diabetes 2008;57(8):2118-27.
2008: Sharad Purohit; Malini Laloraya; Pradeep G Kumar
Distribution of N- and O-linked oligosaccharides on surface of spermatozoa from normal and infertile subjects.
Andrologia 2008;40(1):7-12.
2007: Qing-Guo Ruan; Kenneth Tung; Daniel Eisenman; Yulius Y Setiady; Sarah Eckenrode; Bing Yi; Sharad Purohit; Wei-Peng Zheng; Yan Zhang; Leena Peltonen; Jin-Xiong She
The autoimmune regulator directly controls the expression of genes critical for thymic epithelial function.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(11):7173-80.
2006: Sharad Purohit; Robert Podolsky; Desmond Schatz; Andrew Muir; Diane Hopkins; Yi-Hua Huang; Jin-Xiong She
Assessing the utility of SELDI-TOF and model averaging for serum proteomic biomarker discovery.
Proteomics 2006;6(24):6405-15.
2006: Christin D Collins; Sharad Purohit; Robert Podolsky; H S Zhao; Desmond Schatz; Sarah Eckenrode; Ping Yang; Diane Hopkins; Andrew Muir; M Hoffman; McIndoe Richard; Marian Rewers; Jin-Xiong She
The application of genomic and proteomic technologies in predictive, preventive and personalized medicine.
Vascular pharmacology 2006;45(5):258-67.
2005: Sharad Purohit; Robert Podolsky; Christin Collins; Weipeng Zheng; Desmond Schatz; Andrew Muir; Diane Hopkins; Yi-Hua Huang; Jin-Xiong She
Lack of correlation between the levels of soluble cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and the CT-60 genotypes.
Journal of autoimmune diseases 2005;2():8.
2005: Sharad Purohit; Pradeep G Kumar; Malini Laloraya; Jin-Xiong She
Mapping DNA-binding domains of the autoimmune regulator protein.
Biochemical and biophysical research communications 2005;327(3):939-44.
2004: Dehuang Guo; Manyu Li; Yan Zhang; Ping Yang; Sarah Eckenrode; Diane Hopkins; Weipeng Zheng; Sharad Purohit; Robert Podolsky; Andrew Muir; Jinzhao Wang; Zheng Dong; Todd Brusko; Mark Atkinson; Paolo Pozzilli; Adina Zeidler; Leslie J Raffel; Chaim O Jacob; Yongsoo Park; Manuel Serrano-Rios; Maria T Martinez Larrad; Zixin Zhang; Henri-Jean Garchon; Jean-Francois Bach; Jerome I Rotter; Jin-Xiong She; Cong-Yi Wang
A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes.
Nature genetics 2004;36(8):837-41.
2004: Sharad Purohit; Mopidevi Brahmaraju; Abha Palta; Sunita Shukla; Malini Laloraya; Pradeep G Kumar
Impaired E-cadherin expression in human spermatozoa in a male factor infertility subset signifies E-cadherin-mediated adhesion mechanisms operative in sperm-oolemma interactions.
Biochemical and biophysical research communications 2004;316(3):903-9.
2004: Abdoreza Davoodi-Semiromi; Malini Laloraya; G Pradeep Kumar; Sharad Purohit; Rajesh Kumar Jha; Jin-Xiong She
A mutant Stat5b with weaker DNA binding affinity defines a key defective pathway in nonobese diabetic mice.
The Journal of biological chemistry 2004;279(12):11553-61.
2004: Cong-Yi Wang; Ping Yang; Jing-Da Shi; Sharad Purohit; Dehuang Guo; Haiqian An; Jian-Guo Gu; Jennifer Ling; Zheng Dong; Jin-Xiong She
Molecular cloning and characterization of the mouse Acdp gene family.
BMC genomics 2004;5(1):7.
2000: D Saxena; Sharad Purohit; G P Kumer; Malini Laloraya
Increased appearance of inducible nitric oxide synthase in the uterus and embryo at implantation.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2000;4(4):384-91.
2000: Sharad Purohit; D Saxena; Malini Laloraya; P Kumar G
Altered molecular dynamics and antioxidant status in the spermatozoa in testosterone-induced oligospermia in mouse.
Molecular reproduction and development 2000;55(3):316-25.
1999: Sharad Purohit; Malini Laloraya; G Pradeep Kumar
Role of ions and ion channels in capacitation and acrosome reaction of spermatozoa.
Asian journal of andrology 1999;1(3):95-107.
1999: S Agnihotri; Sharad Purohit; Malini Laloraya; G Pradeep Kumar
Regional heterogeneity in intracellular distribution of superoxide and hydrogen peroxide within the sperm and its relation to sperm development.
Archives of andrology 1999;43(2):113-21.
1998: Sharad Purohit; Malini Laloraya; Pradeep G Kumar
Bicarbonate-dependent lipid ordering and protein aggregation are part of the nongenomic action of progesterone on capacitated spermatozoa.
Journal of andrology 1998;19(5):608-18.
1998: Sharad Purohit; Malini Laloraya; G Pradeep Kumar
Acrosome reaction inducers impose alterations in repulsive strain and hydration barrier in human sperm membranes.
Biochemistry and molecular biology international 1998;45(2):227-35.
1997: S Chatterjee; Sharad Purohit; Malini Laloraya; P Kumar
Vasectomy-induced superoxide dismutase inactivation in the male reproductive tract of rat: a prerequisite for spermatic granuloma formation.
Urologia internationalis 1997;59(1):23-5.
1994: Sharad Purohit; G Pradeep Kumar; Malini Laloraya; M M Laloraya
Involvement of superoxide radical in signal transduction regulating stomatal movements.
Biochemical and biophysical research communications 1994;205(1):30-7.
1992: Sharad Purohit; P Kumar; M Laloraya; S Bharti; Malini Laloraya
ABA-induced 'lipid melting' and its reversal by umbelliferone in the plasmalemma of guard cell protoplasts: a breakthrough in plant hormone-receptor binding and hormone action.
Biochemical and biophysical research communications 1992;186(2):652-8.
1986: Malini Laloraya; C Nozzolillo; Sharad Purohit; L Stevenson
Reversal of Abscisic Acid-Induced Stomatal Closure by trans-Cinnamic and p-Coumaric Acid.
Plant physiology 1986;81(1):253-8.