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Wojciech Danysz

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Caroline Chambon; Andreas Gravius; Claudia Jatzke; Nico Wegener; Wojciech Danysz
Using cholinergic M1 receptor positive allosteric modulators to improve memory via enhancement of brain cholinergic communication.
Martine Hofmann; Kata Bölcskei; Wojciech Danysz; Andrzej Dekundy; László Dézsi; Andreas Gravius; István Gyertyán; Krisztina Sz Kordás; Chris G Parsons; Katalin Sághy; Ina M Wittko-Schneider; Csilla Horváth
Assessment of the effects of NS11394 and L-838417, α2/3 subunit-selective GABA(A) [corrected] receptor-positive allosteric modulators, in tests for pain, anxiety, memory and motor function.
Wojciech Danysz; Chris G Parsons
Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine--searching for the connections.

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All Publications

2012: Caroline Chambon; Andreas Gravius; Claudia Jatzke; Nico Wegener; Wojciech Danysz
Using cholinergic M1 receptor positive allosteric modulators to improve memory via enhancement of brain cholinergic communication.
European journal of pharmacology 2012;697(1-3):73-80.
2012: Martine Hofmann; Kata Bölcskei; Wojciech Danysz; Andrzej Dekundy; László Dézsi; Andreas Gravius; István Gyertyán; Krisztina Sz Kordás; Chris G Parsons; Katalin Sághy; Ina M Wittko-Schneider; Csilla Horváth
Assessment of the effects of NS11394 and L-838417, α2/3 subunit-selective GABA(A) [corrected] receptor-positive allosteric modulators, in tests for pain, anxiety, memory and motor function.
Behavioural pharmacology 2012;23(8):790-801.
2012: Wojciech Danysz; Chris G Parsons
Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine--searching for the connections.
British journal of pharmacology 2012;167(2):324-52.
2011: Caroline Chambon; Andreas Gravius; Nico Wegener; Wojciech Danysz
Behavioural and cellular effects of exogenous amyloid-β peptides in rodents.
Behavioural brain research 2011;225(2):623-41.
2011: Andrzej Dekundy; Andreas Gravius; Mirko Hechenberger; Flora Mela; Jens Nagel; Christopher G Parsons; Malgorzata Pietraszek; Carsten Tober; Martine van der Elst; Wojciech Danysz
Pharmacological characterization of MRZ-8676, a novel negative allosteric modulator of subtype 5 metabotropic glutamate receptors (mGluR5): focus on L: -DOPA-induced dyskinesia.
Journal of neural transmission (Vienna, Austria : 1996) 2011;118(12):1703-16.
2011: Jolanta H Kotlinska; Marcin Bochenski; Wojciech Danysz
The role of group I mGlu receptors in the expression of ethanol-induced conditioned place preference and ethanol withdrawal seizures in rats.
European journal of pharmacology 2011;670(1):154-61.
2011: Nico Wegener; Caroline Chambon; Andreas Gravius; Sergio Greco; Ralph Gross; Jens Nagel; Malgorzata Pietraszek; Wojciech Danysz
Evaluation of brain pharmacokinetics of (+)MK-801 in relation to behaviour.
Neuroscience letters 2011;503(1):68-72.
2011: Caroline Chambon; Nico Wegener; Andreas Gravius; Wojciech Danysz
A new automated method to assess the rat recognition memory: validation of the method.
Behavioural brain research 2011;222(1):151-7.
2010: Y A Novitskaya; Olga A Dravolina; Edwin E Zvartau; Wojciech Danysz; Anton Y Bespalov
Interaction of blockers of ionotropic NMDA receptors and metabotropic glutamate receptors in a working memory test in rats.
Neuroscience and behavioral physiology 2010;40(7):807-11.
2010: Daniella Rylander; Hanna Iderberg; Qin Li; Andrzej Dekundy; Jinlan Zhang; Hao Li; Ren Baishen; Wojciech Danysz; Erwan Bezard; M Angela Cenci
A mGluR5 antagonist under clinical development improves L-DOPA-induced dyskinesia in parkinsonian rats and monkeys.
Neurobiology of disease 2010;39(3):352-61.
2009: Chantal Schlumberger; Malgorzata Pietraszek; Andreas Gravius; Kai-Uwe Klein; Sergio Greco; Lorenzo Morè; Wojciech Danysz
Comparison of the mGlu(5) receptor positive allosteric modulator ADX47273 and the mGlu(2/3) receptor agonist LY354740 in tests for antipsychotic-like activity.
European journal of pharmacology 2009;623(1-3):73-83.
2009: M Alam; Wojciech Danysz; Werner Jürgen Schmidt; Andrzej Dekundy
Effects of glutamate and alpha2-noradrenergic receptor antagonists on the development of neurotoxicity produced by chronic rotenone in rats.
Toxicology and applied pharmacology 2009;240(2):198-207.
2009: Wolfgang Jacob; Andreas Gravius; Malgorzata Pietraszek; Jens Nagel; Irina Belozertseva; Elena Shekunova; Andrey Malyshkin; Sergio Greco; Caroline Barberi; Wojciech Danysz
The anxiolytic and analgesic properties of fenobam, a potent mGlu5 receptor antagonist, in relation to the impairment of learning.
Neuropharmacology 2009;57(2):97-108.
2009: Daniella Rylander; Alessandra Recchia; Flora Mela; Andrzej Dekundy; Wojciech Danysz; M Angela Cenci
Pharmacological modulation of glutamate transmission in a rat model of L-DOPA-induced dyskinesia: effects on motor behavior and striatal nuclear signaling.
The Journal of pharmacology and experimental therapeutics 2009;330(1):227-35.
2009: Chantal Schlumberger; Daniela Schäfer; Caroline Barberi; Lorenzo Morè; Jens Nagel; Malgorzata Pietraszek; Werner J Schmidt; Wojciech Danysz
Effects of a metabotropic glutamate receptor group II agonist LY354740 in animal models of positive schizophrenia symptoms and cognition.
Behavioural pharmacology 2009;20(1):56-66.
2008: Andreas Gravius; Andrzej Dekundy; Jens Nagel; Lorenzo Morè; Malgorzata Pietraszek; Wojciech Danysz
Investigation on tolerance development to subchronic blockade of mGluR5 in models of learning, anxiety, and levodopa-induced dyskinesia in rats.
Journal of neural transmission (Vienna, Austria : 1996) 2008;115(12):1609-19.
2008: Adam Bisaga; Wojciech Danysz; Richard W Foltin
Antagonism of glutamatergic NMDA and mGluR5 receptors decreases consumption of food in baboon model of binge-eating disorder.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2008;18(11):794-802.
2008: Lorenzo Morè; Andreas Gravius; Jens Nagel; Barbara Valastro; Sergio Greco; Wojciech Danysz
Therapeutically relevant plasma concentrations of memantine produce significant L-N-methyl-D-aspartate receptor occupation and do not impair learning in rats.
Behavioural pharmacology 2008;19(7):724-34.
2008: Richard W Foltin; Wojciech Danysz; Adam Bisaga
A novel procedure for assessing the effects of drugs on satiation in baboons: effects of memantine and dexfenfluramine.
Psychopharmacology 2008;199(4):583-92.
2008: Irina A Sukhotina; Olga A Dravolina; Yulia Novitskaya; Edwin E Zvartau; Wojciech Danysz; Anton Y Bespalov
Effects of mGlu1 receptor blockade on working memory, time estimation, and impulsivity in rats.
Psychopharmacology 2008;196(2):211-20.
2008: Anna Kiryk; Tomomi Aida; Kohichi Tanaka; Pradeep Banerjee; Grzegorz M Wilczynski; Ksenia Meyza; Ewelina Knapska; Robert Filipkowski; Leszek Kaczmarek; Wojciech Danysz
Behavioral characterization of GLT1 (+/-) mice as a model of mild glutamatergic hyperfunction.
Neurotoxicity research 2008;13(1):19-30.
2008: Karolina Stepien; Wojciech Danysz; Stanislaw J Czuczwar
Interactions of MRZ 2/576 with felbamate, lamotrigine, oxcarbazepine and topiramate in the mouse maximal electroshock-induced seizure model.
Pharmacology 2008;81(3):259-65.
2007: Chris G Parsons; Albrecht Stöffler; Wojciech Danysz
Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system--too little activation is bad, too much is even worse.
Neuropharmacology 2007;53(6):699-723.
2007: Barbara Valastro; Andrzej Dekundy; Morten Krogh; Martin Lundblad; Peter James; Wojciech Danysz; Guenter Quack; M Angela Cenci
Proteomic analysis of striatal proteins in the rat model of L-DOPA-induced dyskinesia.
Journal of neurochemistry 2007;102(4):1395-409.
2007: Lorenzo Morè; Andreas Gravius; Malgorzata Pietraszek; Irina Belozertseva; Andrey A Malyshkin; Elena V Shekunova; Caroline Barberi; Daniela Schaefer; Werner J Schmidt; Wojciech Danysz
Comparison of the mGluR1 antagonist A-841720 in rat models of pain and cognition.
Behavioural pharmacology 2007;18(4):273-81.
2007: Andrzej Dekundy; Martin Lundblad; Wojciech Danysz; M Angela Cenci
Modulation of L-DOPA-induced abnormal involuntary movements by clinically tested compounds: further validation of the rat dyskinesia model.
Behavioural brain research 2007;179(1):76-89.
2007: Flora Mela; Matteo Marti; Andrzej Dekundy; Wojciech Danysz; Michele Morari; M Angela Cenci
Antagonism of metabotropic glutamate receptor type 5 attenuates l-DOPA-induced dyskinesia and its molecular and neurochemical correlates in a rat model of Parkinson's disease.
Journal of neurochemistry 2007;101(2):483-97.
2007: Olga A Dravolina; Elena S Zakharova; Elena V Shekunova; Edwin E Zvartau; Wojciech Danysz; Anton Y Bespalov
mGlu1 receptor blockade attenuates cue- and nicotine-induced reinstatement of extinguished nicotine self-administration behavior in rats.
Neuropharmacology 2007;52(2):263-9.
2007: Malgorzata Pietraszek; J Nagel; Andreas Gravius; D Schäfer; Wojciech Danysz
The role of group I metabotropic glutamate receptors in schizophrenia.
Amino acids 2007;32(2):173-8.
2007: Irina Belozertseva; Tomasz Kos; Piotr Popik; Wojciech Danysz; Anton Y Bespalov
Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and the mouse tail suspension tests.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2007;17(3):172-9.
2007: Kinga Szydlowska; Bozena Kaminska; Andrea Baude; Chris G Parsons; Wojciech Danysz
Neuroprotective activity of selective mGlu1 and mGlu5 antagonists in vitro and in vivo.
European journal of pharmacology 2007;554(1):18-29.
2006: Jens Nagel; Irina Belozertseva; Sergio Greco; Vladimir Kashkin; Andrey A Malyshkin; Aigars Jirgensons; Elena V Shekunova; Bernd Eilbacher; Anton Y Bespalov; Wojciech Danysz
Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain - relation to brain concentration.
Neuropharmacology 2006;51(7-8):1163-71.
2006: Andreas Gravius; C Barberi; D Schäfer; Werner J Schmidt; Wojciech Danysz
The role of group I metabotropic glutamate receptors in acquisition and expression of contextual and auditory fear conditioning in rats - a comparison.
Neuropharmacology 2006;51(7-8):1146-55.
2006: Phillip R Zoladz; Adam M Campbell; Collin R Park; Daniela Schaefer; Wojciech Danysz; David M Diamond
Enhancement of long-term spatial memory in adult rats by the noncompetitive NMDA receptor antagonists, memantine and neramexane.
Pharmacology, biochemistry, and behavior 2006;85(2):298-306.
2006: Gary L Wenk; Chris G Parsons; Wojciech Danysz
Potential role of N-methyl-D-aspartate receptors as executors of neurodegeneration resulting from diverse insults: focus on memantine.
Behavioural pharmacology 2006;17(5-6):411-24.
2006: Olga A Dravolina; Wojciech Danysz; Anton Y Bespalov
Effects of group I metabotropic glutamate receptor antagonists on the behavioral sensitization to motor effects of cocaine in rats.
Psychopharmacology 2006;187(4):397-404.
2006: Natalia Y Sevostianova; Wojciech Danysz
Analgesic effects of mGlu1 and mGlu5 receptor antagonists in the rat formalin test.
Neuropharmacology 2006;51(3):623-30.
2006: Tomasz Kos; Beata Legutko; Wojciech Danysz; Gary Samoriski; Piotr Popik
Enhancement of antidepressant-like effects but not brain-derived neurotrophic factor mRNA expression by the novel N-methyl-D-aspartate receptor antagonist neramexane in mice.
The Journal of pharmacology and experimental therapeutics 2006;318(3):1128-36.
2006: Wolfgang Löscher; Andrzej Dekundy; Jens Nagel; Wojciech Danysz; Chris G Parsons; Heidrun Potschka
mGlu1 and mGlu5 receptor antagonists lack anticonvulsant efficacy in rodent models of difficult-to-treat partial epilepsy.
Neuropharmacology 2006;50(8):1006-15.
2006: Dorota Makarewicz; Malgorzata Duszczyk; Roman Gadamski; Wojciech Danysz; Jerzy W Łazarewicz
Neuroprotective potential of group I metabotropic glutamate receptor antagonists in two ischemic models.
Neurochemistry international 2006;48(6-7):485-90.
2006: Tomasz Kos; Piotr Popik; Malgorzata Pietraszek; D Schäfer; Wojciech Danysz; Olga A Dravolina; Elena A Blokhina; T Galankin; Anton Y Bespalov
Effect of 5-HT3 receptor antagonist MDL 72222 on behaviors induced by ketamine in rats and mice.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2006;16(4):297-310.
2006: Andrzej Dekundy; Malgorzata Pietraszek; Daniela Schaefer; M Angela Cenci; Wojciech Danysz
Effects of group I metabotropic glutamate receptors blockade in experimental models of Parkinson's disease.
Brain research bulletin 2006;69(3):318-26.
2006: Andreas Gravius; Malgorzata Pietraszek; Werner J Schmidt; Wojciech Danysz
Functional interaction of NMDA and group I metabotropic glutamate receptors in negatively reinforced learning in rats.
Psychopharmacology 2006;185(1):58-65.
2006: Jolanta Kotlinska; Marcin Bochenski; Wojciech Danysz
N-methyl-D-aspartate and group I metabotropic glutamate receptors are involved in the expression of ethanol-induced sensitization in mice.
Behavioural pharmacology 2006;17(1):1-8.
2005: Natalia Y Sevostianova; Wojciech Danysz; Anton Y Bespalov
Analgesic effects of morphine and loperamide in the rat formalin test: interactions with NMDA receptor antagonists.
European journal of pharmacology 2005;525(1-3):83-90.
2005: Andrey A Malyshkin; Ivan O Medvedev; Wojciech Danysz; Anton Y Bespalov
Anti-allodynic interactions between NMDA receptor channel blockers and morphine or clonidine in neuropathic rats.
European journal of pharmacology 2005;519(1-2):80-5.
2005: Wojciech Danysz
LY-544344. Eli Lilly.
IDrugs : the investigational drugs journal 2005;8(9):755-62.
2005: Malgorzata Pietraszek; Andreas Gravius; D Schäfer; T Weil; D Trifanova; Wojciech Danysz
mGluR5, but not mGluR1, antagonist modifies MK-801-induced locomotor activity and deficit of prepulse inhibition.
Neuropharmacology 2005;49(1):73-85.
2005: Daniel Bachteler; Daina Economidou; Wojciech Danysz; Roberto Ciccocioppo; Rainer Spanagel
The effects of acamprosate and neramexane on cue-induced reinstatement of ethanol-seeking behavior in rat.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(6):1104-10.
2005: Malgorzata Pietraszek; Ilya Sukhanov; Piotr Maciejak; Janusz Szyndler; Andreas Gravius; Aleksandra Wisłowska; Adam Płaźnik; Anton Y Bespalov; Wojciech Danysz
Anxiolytic-like effects of mGlu1 and mGlu5 receptor antagonists in rats.
European journal of pharmacology 2005;514(1):25-34.
2005: Valentina Vengeliene; Daniel Bachteler; Wojciech Danysz; Rainer Spanagel
The role of the NMDA receptor in alcohol relapse: a pharmacological mapping study using the alcohol deprivation effect.
Neuropharmacology 2005;48(6):822-9.
2005: Elena S Zakharova; Wojciech Danysz; Anton Y Bespalov
Drug discrimination analysis of NMDA receptor channel blockers as nicotinic receptor antagonists in rats.
Psychopharmacology 2005;179(1):128-35.
2005: Andreas Gravius; Malgorzata Pietraszek; D Schäfer; Werner J Schmidt; Wojciech Danysz
Effects of mGlu1 and mGlu5 receptor antagonists on negatively reinforced learning.
Behavioural pharmacology 2005;16(2):113-21.
2005: Wojciech Danysz; Ewa Kozela; Christopher G Parsons; Meik Sladek; Tanja Bauer; Piotr Popik
Peripherally acting NMDA receptor/glycineB site receptor antagonists inhibit morphine tolerance.
Neuropharmacology 2005;48(3):360-71.
2005: Elena A Blokhina; Vladimir A Kashkin; Edwin E Zvartau; Wojciech Danysz; Anton Y Bespalov
Effects of nicotinic and NMDA receptor channel blockers on intravenous cocaine and nicotine self-administration in mice.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2005;15(2):219-25.
2005: Elzbieta Salińska; Wojciech Danysz; Jerzy W Łazarewicz
The role of excitotoxicity in neurodegeneration.
Folia neuropathologica / Association of Polish Neuropathologists and Medical Research Centre, Polish Academy of Sciences 2005;43(4):322-39.
2005: Malgorzata Duszczyk; Roman Gadamski; Apolonia Ziembowicz; Wojciech Danysz; Jerzy W Lazarewicz
NMDA receptor antagonism does not inhibit induction of ischemic tolerance in gerbil brain in vivo.
Neurotoxicity research 2005;7(4):283-92.
2005: Anton Y Bespalov; Olga A Dravolina; Ilya Sukhanov; Elena S Zakharova; Elena A Blokhina; Edwin E Zvartau; Wojciech Danysz; Gino van Heeke; Athina Markou
Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cue- and schedule-induced reinstatement of nicotine self-administration behavior in rats.
Neuropharmacology 2005;49 Suppl 1():167-78.
2004: Jolanta Kotlinska; Grazyna Biala; Piotr Rafalski; Marcin Bochenski; Wojciech Danysz
Effect of neramexane on ethanol dependence and reinforcement.
European journal of pharmacology 2004;503(1-3):95-8.
2004: Ivan O Medvedev; Andrey A Malyshkin; Irina Belozertseva; Irina A Sukhotina; Natalia Y Sevostianova; Kamal Aliev; Edwin E Zvartau; Chris G Parsons; Wojciech Danysz; Anton Y Bespalov
Effects of low-affinity NMDA receptor channel blockers in two rat models of chronic pain.
Neuropharmacology 2004;47(2):175-83.
2004: Elena S Zakharova; Andrey A Malyshkin; Vladimir A Kashkin; Olga N Neznanova; Irina A Sukhotina; Wojciech Danysz; Anton Y Bespalov
The NMDA receptor channel blocker memantine and opioid receptor antagonist naltrexone inhibit the saccharin deprivation effect in rats.
Behavioural pharmacology 2004;15(4):273-8.
2004: Ilya Sukhanov; Elena S Zakharova; Wojciech Danysz; Anton Y Bespalov
Effects of NMDA receptor channel blockers, MK-801 and memantine, on locomotor activity and tolerance to delay of reward in Wistar-Kyoto and spontaneously hypertensive rats.
Behavioural pharmacology 2004;15(4):263-71.
2004: Irina A Sukhotina; Edwin E Zvartau; Wojciech Danysz; Anton Y Bespalov
Caffeine withdrawal syndrome in social interaction test in mice: effects of the NMDA receptor channel blockers, memantine and neramexane.
Behavioural pharmacology 2004;15(3):207-14.
2004: Undine E Lang; M Mühlbacher; M B Hesselink; Wojciech Zajaczkowski; Wojciech Danysz; Heidi Danker-Hopfe; Rainer Hellweg
No nerve growth factor response to treatment with memantine in adult rats.
Journal of neural transmission (Vienna, Austria : 1996) 2004;111(2):181-90.
2004: Wojciech Danysz
Society of neuroscience-33rd annual meeting: metabotropic glutamate receptors.
IDrugs : the investigational drugs journal 2004;7(1):9-14.
2003: Wojciech Danysz; Chris G Parsons
The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer's disease: preclinical evidence.
International journal of geriatric psychiatry 2003;18(Suppl 1):S23-32.
2003: Wolfgang Löscher; Heidrun Potschka; Piotr Wlaź; Wojciech Danysz; Christopher G Parsons
Are neuronal nicotinic receptors a target for antiepileptic drug development? Studies in different seizure models in mice and rats.
European journal of pharmacology 2003;466(1-2):99-111.
2003: Natalia Y Sevostianova; Edwin E Zvartau; Anton Y Bespalov; Wojciech Danysz
Effects of morphine on formalin-induced nociception in rats.
European journal of pharmacology 2003;462(1-3):109-13.
2002: Wojciech Danysz
The glutamatergic system.
IDrugs : the investigational drugs journal 2002;5(12):1104-6.
2002: Wojciech Danysz
CX-516 Cortex pharmaceuticals.
Current opinion in investigational drugs (London, England : 2000) 2002;3(7):1081-8.
2002: Wojciech Danysz
Positive modulators of AMPA receptors as a potential treatment for schizophrenia.
Current opinion in investigational drugs (London, England : 2000) 2002;3(7):1062-6.
2002: Zofia Rogóz; Grazyna Skuza; Jerzy Maj; Wojciech Danysz
Synergistic effect of uncompetitive NMDA receptor antagonists and antidepressant drugs in the forced swimming test in rats.
Neuropharmacology 2002;42(8):1024-30.
2002: Monika Sopala; Steffen Schweizer; Nicole Schäfer; Eberhard Nürnberg; Jörg Kreuter; Erhard Seiller; Wojciech Danysz
Neuroprotective activity of a nanoparticulate formulation of the glycineB site antagonist MRZ 2/576 in transient focal ischaemia in rats.
Arzneimittel-Forschung 2002;52(3):168-74.
2002: Wojciech Danysz; Christopher G Parsons; Aigars Jirgensons; V Kauss; J Tillner
Amino-alkyl-cyclohexanes as a novel class of uncompetitive NMDA receptor antagonists.
Current pharmaceutical design 2002;8(10):835-43.
2001: Ewa Kozela; Wojciech Danysz; Piotr Popik
Uncompetitive NMDA receptor antagonists potentiate morphine antinociception recorded from the tail but not from the hind paw in rats.
European journal of pharmacology 2001;423(1):17-26.
2001: Przemyslaw Bienkowski; Pawel Krzascik; Eliza Koros; Wojciech Kostowski; Anna Scinska; Wojciech Danysz
Effects of a novel uncompetitive NMDA receptor antagonist, MRZ 2/579 on ethanol self-administration and ethanol withdrawal seizures in the rat.
European journal of pharmacology 2001;413(1):81-9.
2001: Monika Sopala; Wojciech Danysz
Chronic cerebral hypoperfusion in the rat enhances age-related deficits in spatial memory.
Journal of neural transmission (Vienna, Austria : 1996) 2001;108(12):1445-56.
2000: LB Willard; Beatrice Hauss-Wegrzyniak; Wojciech Danysz; Gary L Wenk
The cytotoxicity of chronic neuroinflammation upon basal forebrain cholinergic neurons of rats can be attenuated by glutamatergic antagonism or cyclooxygenase-2 inhibition.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 2000;134(1):58-65.
2000: Aigars Jirgensons; V Kauss; Ivars Kalvinsh; M R Gold; Wojciech Danysz; Christopher G Parsons; G Quack
Synthesis and structure-affinity relationships of 1,3, 5-alkylsubstituted cyclohexylamines binding at NMDA receptor PCP site.
European journal of medicinal chemistry 2000;35(6):555-65.
2000: Irina Belozertseva; Wojciech Danysz; Anton Y Bespalov
Effects of short-acting NMDA receptor antagonist MRZ 2/576 on morphine tolerance development in mice.
Naunyn-Schmiedeberg's archives of pharmacology 2000;361(6):573-7.
2000: Irina Belozertseva; Olga A Dravolina; Olga N Neznanova; Wojciech Danysz; Anton Y Bespalov
Antinociceptive activity of combination of morphine and NMDA receptor antagonists depends on the inter-injection interval.
European journal of pharmacology 2000;396(2-3):77-83.
2000: Wojciech Zajaczkowski; Michal Hetman; Evgeni Nikolaev; G Quack; Wojciech Danysz; Leszek Kaczmarek
Behavioural evaluation of long-term neurotoxic effects of NMDA receptor antagonists.
Neurotoxicity research 2000;1(4):299-310.
2000: Piotr Popik; Ewa Kozela; Wojciech Danysz
Clinically available NMDA receptor antagonists memantine and dextromethorphan reverse existing tolerance to the antinociceptive effects of morphine in mice.
Naunyn-Schmiedeberg's archives of pharmacology 2000;361(4):425-32.
2000: Monika Sopala; Tadeusz Frankiewicz; C Parsons; Wojciech Danysz
Middle cerebral artery occlusion produces secondary, remote impairment in hippocampal plasticity of rats - involvement of N-methyl-D-aspartate receptors?
Neuroscience letters 2000;281(2-3):143-6.
2000: Irina Belozertseva; Wojciech Danysz; Anton Y Bespalov
Short-acting NMDA receptor antagonist MRZ 2/576 produces prolonged suppression of morphine withdrawal in mice.
Naunyn-Schmiedeberg's archives of pharmacology 2000;361(3):279-82.
2000: Gary L Wenk; G Quack; H J Moebius; Wojciech Danysz
No interaction of memantine with acetylcholinesterase inhibitors approved for clinical use.
Life sciences 2000;66(12):1079-83.
2000: Wojciech Danysz; Christopher G Parsons; H J Mobius; Albrecht Stöffler; G Quack
Neuroprotective and symptomatological action of memantine relevant for Alzheimer's disease--a unified glutamatergic hypothesis on the mechanism of action.
Neurotoxicity research 2000;2(2-3):85-97.
2000: Wojciech Danysz; Christopher G Parsons; G Quack
NMDA channel blockers: memantine and amino-aklylcyclohexanes--in vivo characterization.
Amino acids 2000;19(1):167-72.
2000: Christopher G Parsons; Wojciech Danysz; G Quack
Memantine and the amino-alkyl-cyclohexane MRZ 2/579 are moderate affinity uncompetitive NMDA receptor antagonists--in vitro characterisation.
Amino acids 2000;19(1):157-66.
1999: MB Hesselink; Christopher G Parsons; C Wollenburg; Wojciech Danysz
Brain distribution of an uncompetitive NMDA receptor antagonist; comparison to its in vitro potency in electrophysiological studies.
Naunyn-Schmiedeberg's archives of pharmacology 1999;360(2):144-50.
1999: MB Hesselink; H Smolders; Bernd Eilbacher; Albertus G de Boer; Douwe D Breimer; Wojciech Danysz
The role of probenecid-sensitive organic acid transport in the pharmacokinetics of N-methyl-D-aspartate receptor antagonists acting at the glycine(B)-site: microdialysis and maximum electroshock seizures studies.
The Journal of pharmacology and experimental therapeutics 1999;290(2):543-50.
1999: Svetlana Semenova; Wojciech Danysz; Anton Y Bespalov
Low-affinity NMDA receptor channel blockers inhibit acquisition of intravenous morphine self-administration in naive mice.
European journal of pharmacology 1999;378(1):1-8.
1999: Christopher G Parsons; Wojciech Danysz; G Quack
Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist--a review of preclinical data.
Neuropharmacology 1999;38(6):735-67.
1999: Przemyslaw Bienkowski; Eliza Koros; Wojciech Kostowski; Wojciech Danysz
Effects of N-methyl-D-aspartate receptor antagonists on reinforced and nonreinforced responding for ethanol in rats.
Alcohol (Fayetteville, N.Y.) 1999;18(2-3):131-7.
1999: MB Hesselink; B G De Boer; Douwe D Breimer; Wojciech Danysz
Brain penetration and in vivo recovery of NMDA receptor antagonists amantadine and memantine: a quantitative microdialysis study.
Pharmaceutical research 1999;16(5):637-42.
1999: MB Hesselink; H Smolders; Albertus G de Boer; Douwe D Breimer; Wojciech Danysz
Modifications of the behavioral profile of non-competitive NMDA receptor antagonists, memantine, amantadine and (+)MK-801 after chronic administration.
Behavioural pharmacology 1999;10(1):85-98.
1999: Eliza Koros; Wojciech Kostowski; Wojciech Danysz; Przemyslaw Bienkowski
Ethanol discrimination in the rat: lack of modulation by restraint stress and memantine.
Naunyn-Schmiedeberg's archives of pharmacology 1999;359(2):117-22.
1999: M Karcz-Kubicha; Krzysztof Wedzony; Wojciech Zajaczkowski; Wojciech Danysz
NMDA receptor antagonists acting at the glycineB site in rat models for antipsychotic-like activity.
Journal of neural transmission (Vienna, Austria : 1996) 1999;106(11-12):1189-204.
1999: MB Hesselink; Albertus G de Boer; Douwe D Breimer; Wojciech Danysz
Dopamine release in the prefrontal cortex in response to memantine following sub-chronic NMDA receptor blockade with memantine: a microdialysis study in rats.
Journal of neural transmission (Vienna, Austria : 1996) 1999;106(9-10):803-18.
1999: MB Hesselink; Albertus G de Boer; Douwe D Breimer; Wojciech Danysz
Adaptations of NMDA and dopamine D2, but not of muscarinic receptors following 14 days administration of uncompetitive NMDA receptor antagonists.
Journal of neural transmission (Vienna, Austria : 1996) 1999;106(5-6):409-21.
1999: M Karcz-Kubicha; B Lorenz; Wojciech Danysz
GlycineB antagonists and partial agonists in rodent models of Parkinson's disease--comparison with uncompetitive N-methyl-D-aspartate receptor antagonist.
Neuropharmacology 1999;38(1):109-19.
1999: Christopher G Parsons; Wojciech Danysz; A Bartmann; P Spielmanns; Tadeusz Frankiewicz; MB Hesselink; Bernd Eilbacher; G Quack
Amino-alkyl-cyclohexanes are novel uncompetitive NMDA receptor antagonists with strong voltage-dependency and fast blocking kinetics: in vitro and in vivo characterization.
Neuropharmacology 1999;38(1):85-108.
1998: Wojciech Danysz; C G Parsons
Glycine and N-methyl-D-aspartate receptors: physiological significance and possible therapeutic applications.
Pharmacological reviews 1998;50(4):597-664.
1998: Christopher G Parsons; Wojciech Danysz; G Quack
Glutamate in CNS disorders as a target for drug development: an update.
Drug news & perspectives 1998;11(9):523-69.
1998: J Piasecki; Eliza Koros; Wanda Dyr; Wojciech Kostowski; Wojciech Danysz; Przemyslaw Bienkowski
Ethanol-reinforced behaviour in the rat: effects of uncompetitive NMDA receptor antagonist, memantine.
European journal of pharmacology 1998;354(2-3):135-43.
1998: Piotr Popik; J Mamczarz; M Fraczek; M Widła; M Hesselink; Wojciech Danysz
Inhibition of reinforcing effects of morphine and naloxone-precipitated opioid withdrawal by novel glycine site and uncompetitive NMDA receptor antagonists.
Neuropharmacology 1998;37(8):1033-42.
1998: Gary L Wenk; LM Baker; JD Stoehr; Beatrice Hauss-Wegrzyniak; Wojciech Danysz
Neuroprotection by novel antagonists at the NMDA receptor channel and glycineB sites.
European journal of pharmacology 1998;347(2-3):183-7.
1998: M Karcz-Kubicha; G Quack; Wojciech Danysz
Amantadine attenuates response alterations resulting from repetitive L-DOPA treatment in rats.
Journal of neural transmission (Vienna, Austria : 1996) 1998;105(10-12):1229-36.
1998: Wojciech Danysz; Christopher G Parsons; M Karcz-Kubicha; A Schwaier; Piotr Popik; Krzysztof Wedzony; Jerzy W Lazarewicz; G Quack
GlycineB antagonists as potential therapeutic agents. Previous hopes and present reality.
Amino acids 1998;14(1-3):235-9.
1998: Gary L Wenk; LM Baker; Beatrice Hauss-Wegrzyniak; Wojciech Danysz; JD Stoehr
Novel glycineB antagonists show neuroprotective activity in vivo.
Amino acids 1998;14(1-3):223-6.
1998: Christopher G Parsons; Wojciech Danysz; MB Hesselink; S Hartmann; B Lorenz; C Wollenburg; G Quack
Modulation of NMDA receptors by glycine--introduction to some basic aspects and recent developments.
Amino acids 1998;14(1-3):207-16.
1998: Przemyslaw Bienkowski; Wojciech Danysz; Wojciech Kostowski
Study on the role of glycine, strychnine-insensitive receptors (glycineB sites) in the discriminative stimulus effects of ethanol in the rat.
Alcohol (Fayetteville, N.Y.) 1998;15(1):87-91.
1997: Christopher G Parsons; Wojciech Danysz; G Quack; S Hartmann; B Lorenz; C Wollenburg; L Baran; Edmund Przegalinski; Wojciech Kostowski; Pawel Krzascik; Boris A Chizh; P Max Headley
Novel systemically active antagonists of the glycine site of the N-methyl-D-aspartate receptor: electrophysiological, biochemical and behavioral characterization.
The Journal of pharmacology and experimental therapeutics 1997;283(3):1264-75.
1997: M Karcz-Kubicha; M Jessa; M Nazar; Adam Plaznik; S Hartmann; Christopher G Parsons; Wojciech Danysz
Anxiolytic activity of glycine-B antagonists and partial agonists--no relation to intrinsic activity in the patch clamp.
Neuropharmacology 1997;36(10):1355-67.
1997: Michal Hetman; Wojciech Danysz; Leszek Kaczmarek
Increased expression of cathepsin D in retrosplenial cortex of MK-801-treated rats.
Experimental neurology 1997;147(2):229-37.
1997: Wojciech Zajaczkowski; Tadeusz Frankiewicz; Christopher G Parsons; Wojciech Danysz
Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP.
Neuropharmacology 1997;36(7):961-71.
1997: Wojciech Danysz; Christopher G Parsons; J Kornhuber; W J Schmidt; G Quack
Aminoadamantanes as NMDA receptor antagonists and antiparkinsonian agents--preclinical studies.
Neuroscience and biobehavioral reviews 1997;21(4):455-68.
1997: Gary L Wenk; Wojciech Zajaczkowski; Wojciech Danysz
Neuroprotection of acetylcholinergic basal forebrain neurons by memantine and neurokinin B.
Behavioural brain research 1997;83(1-2):129-33.
1997: Piotr Popik; Wojciech Danysz
Inhibition of reinforcing effects of morphine and motivational aspects of naloxone-precipitated opioid withdrawal by N-methyl-D-aspartate receptor antagonist, memantine.
The Journal of pharmacology and experimental therapeutics 1997;280(2):854-65.
1997: Jerzy W Lazarewicz; Roman Gadamski; C G Parsons; Wojciech Danysz
Protection against post-ischaemic neuronal loss in gerbil hippocampal CA1 by glycineB and AMPA antagonists. Short communication.
Journal of neural transmission (Vienna, Austria : 1996) 1997;104(11-12):1249-54.
1997: Wojciech Zajaczkowski; Wojciech Danysz
Effects of D-cycloserine and aniracetam on spatial learning in rats with entorhinal cortex lesions.
Pharmacology, biochemistry, and behavior 1997;56(1):21-9.
1996: Gary L Wenk; Wojciech Danysz; D D Roice
The effects of mitochondrial failure upon cholinergic toxicity in the nucleus basalis.
Neuroreport 1996;7(9):1453-6.
1996: M Misztal; J Skangiel-Kramska; G Niewiadomska; Wojciech Danysz
Subchronic intraventricular infusion of quinolinic acid produces working memory impairment--a model of progressive excitotoxicity.
Neuropharmacology 1996;35(4):449-58.
1996: Carol A Barnes; Wojciech Danysz; C G Parsons
Effects of the uncompetitive NMDA receptor antagonist memantine on hippocampal long-term potentiation, short-term exploratory modulation and spatial memory in awake, freely moving rats.
The European journal of neuroscience 1996;8(3):565-71.
1996: Wojciech Zajaczkowski; G Quack; Wojciech Danysz
Infusion of (+) -MK-801 and memantine -- contrasting effects on radial maze learning in rats with entorhinal cortex lesion.
European journal of pharmacology 1996;296(3):239-46.
1996: M Misztal; Tadeusz Frankiewicz; Christopher G Parsons; Wojciech Danysz
Learning deficits induced by chronic intraventricular infusion of quinolinic acid--protection by MK-801 and memantine.
European journal of pharmacology 1996;296(1):1-8.
1996: Wojciech Danysz; R Raulli; Jarda T Wroblewski
Concanavalin A enhances quisqualate-induced calcium influx in cerebellar granule cells in culture.
Acta neurobiologiae experimentalis 1996;56(3):649-56.
1995: Gary L Wenk; Wojciech Danysz; S L Mobley
MK-801, memantine and amantadine show neuroprotective activity in the nucleus basalis magnocellularis.
European journal of pharmacology 1995;293(3):267-70.
1995: Christopher G Parsons; G Quack; I Bresink; L Baran; Edmund Przegalinski; W Kostowski; P Krzascik; S Hartmann; Wojciech Danysz
Comparison of the potency, kinetics and voltage-dependency of a series of uncompetitive NMDA receptor antagonists in vitro with anticonvulsive and motor impairment activity in vivo.
Neuropharmacology 1995;34(10):1239-58.
1995: I Bresink; Wojciech Danysz; Christopher G Parsons; E Mutschler
Different binding affinities of NMDA receptor channel blockers in various brain regions--indication of NMDA receptor heterogeneity.
Neuropharmacology 1995;34(5):533-40.
1995: G Quack; MB Hesselink; Wojciech Danysz; R Spanagel
Microdialysis studies with amantadine and memantine on pharmacokinetics and effects on dopamine turnover.
Journal of neural transmission. Supplementum 1995;46():97-105.
1995: M Gossel; W J Schmidt; W Löscher; Wojciech Zajaczkowski; Wojciech Danysz
Effect of coadministration of glutamate receptor antagonists and dopaminergic agonists on locomotion in monoamine-depleted rats.
Journal of neural transmission. Parkinson's disease and dementia section 1995;10(1):27-39.
1995: I Bresink; Wojciech Danysz; Christopher G Parsons; P Tiedtke; E Mutschler
Chronic treatment with the uncompetitive NMDA receptor antagonist memantine influences the polyamine and glycine binding sites of the NMDA receptor complex in aged rats.
Journal of neural transmission. Parkinson's disease and dementia section 1995;10(1):11-26.
1994: Gary L Wenk; Wojciech Danysz; S L Mobley
Investigations of neurotoxicity and neuroprotection within the nucleus basalis of the rat.
Brain research 1994;655(1-2):7-11.
1994: Wojciech Danysz; U Essmann; I Bresink; R Wilke
Glutamate antagonists have different effects on spontaneous locomotor activity in rats.
Pharmacology, biochemistry, and behavior 1994;48(1):111-8.
1994: Grazyna Skuza; Z Rogoz; G Quack; Wojciech Danysz
Memantine, amantadine, and L-deprenyl potentiate the action of L-dopa in monoamine-depleted rats.
Journal of neural transmission. General section 1994;98(1):57-67.
1994: Wojciech Danysz; M Gossel; Wojciech Zajaczkowski; D Dill; G Quack
Are NMDA antagonistic properties relevant for antiparkinsonian-like activity in rats?--case of amantadine and memantine.
Journal of neural transmission. Parkinson's disease and dementia section 1994;7(3):155-66.
1993: Adam Bisaga; P Krzascik; E Jankowska; W Palejko; Wojciech Kostowski; Wojciech Danysz
Effect of glutamate receptor antagonists on N-methyl-D-aspartate- and (S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-induced convulsant effects in mice and rats.
European journal of pharmacology 1993;242(3):213-20.
1992: Wojciech Danysz; Wanda Dyr; E Jankowska; S Glazewski; Wojciech Kostowski
The involvement of NMDA receptors in acute and chronic effects of ethanol.
Alcoholism, clinical and experimental research 1992;16(3):499-504.
1991: Wojciech Kostowski; Wojciech Danysz; Wanda Dyr; E Jankowska; P Krzaścik; W Pałejko; R Stefański; A Płaźnik
MIF-1 potentiates the action of tricyclic antidepressants in an animal model of depression.
Peptides 1991;12(5):915-8.
1991: R Raulli; Wojciech Danysz; Jarda T Wroblewski
Pretreatment of cerebellar granule cells with concanavalin A potentiates quisqualate-stimulated phosphoinositide hydrolysis.
Journal of neurochemistry 1991;56(6):2116-24.
1991: Wojciech Danysz
Metaphit fails to antagonize PCP-induced passive avoidance deficit.
Pharmacology, biochemistry, and behavior 1991;38(1):231-3.
1990: Wojciech Danysz; E Fadda; Jarda T Wroblewski; Erminio Costa
[3H]D-serine labels strychnine-insensitive glycine recognition sites of rat central nervous system.
Life sciences 1990;46(3):155-64.
1989: Wojciech Danysz; E Fadda; Jarda T Wroblewski; Erminio Costa
Different modes of action of 3-amino-1-hydroxy-2-pyrrolidone (HA-966) and 7-chlorokynurenic acid in the modulation of N-methyl-D-aspartate-sensitive glutamate receptors.
Molecular pharmacology 1989;36(6):912-6.
1989: Wojciech Danysz; Jarda T Wroblewski; Gary Brooker; Erminio Costa
Modulation of glutamate receptors by phencyclidine and glycine in the rat cerebellum: cGMP increase in vivo.
Brain research 1989;479(2):270-6.
1989: Wojciech Danysz; E Fadda; Jarda T Wroblewski; Erminio Costa
Kynurenate and 2-amino-5-phosphonovalerate interact with multiple binding sites of the N-methyl-D-aspartate-sensitive glutamate receptor domain.
Neuroscience letters 1989;96(3):340-4.
1989: Wojciech Danysz; Wanda Dyr; A Płaznik; Wojciech Kostowski
The effect of microinjections of clonidine into the locus coeruleus on cortical EEG in rats.
Polish journal of pharmacology and pharmacy 1989;41(1):45-50.
1989: Jarda T Wroblewski; Wojciech Danysz
Modulation of glutamate receptors: molecular mechanisms and functional implications.
Annual review of pharmacology and toxicology 1989;29():441-74.
1988: E Fadda; Wojciech Danysz; Jarda T Wroblewski; Erminio Costa
Glycine and D-serine increase the affinity of N-methyl-D-aspartate sensitive glutamate binding sites in rat brain synaptic membranes.
Neuropharmacology 1988;27(11):1183-5.
1988: Wojciech Danysz; Jarda T Wroblewski; Erminio Costa
Learning impairment in rats by N-methyl-D-aspartate receptor antagonists.
Neuropharmacology 1988;27(6):653-6.
1988: Wojciech Danysz; Adam Plaznik; Wojciech Kostowski; E Malatynska; T U Järbe; Arto J Hiltunen; T Archer
Comparison of desipramine, amitriptyline, zimeldine and alaproclate in six animal models used to investigate antidepressant drugs.
Pharmacology & toxicology 1988;62(1):42-50.
1986: Wojciech Kostowski; E Malatyńska; A Płaźnik; Wanda Dyr; Wojciech Danysz
Comparative studies on antidepressant action of alprazolam in different animal models.
Polish journal of pharmacology and pharmacy 1986;38(5-6):471-81.