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Ratna Vadlamudi

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Quan-Guang Zhang; Yan Dong; Dong Han; Gangadhara Reddy Sareddy; Erin Scott; Jing-Yi Tu; Ratna K Vadlamudi; Rui-Min Wang; Fang Yang; Darrell W Brann
Hypersensitivity of the hippocampal CA3 region to stress-induced neurodegeneration and amyloidogenesis in a rat model of surgical menopause.
Gangadhara R Sareddy; Takayoshi Suzuki; Quan-guang Zhang; Darrell W Brann; Andrew J Brenner; Vijay K Gonugunta; Samaya K Krishnan; Naoki Miyata; Binoj C Nair; Ratna K Vadlamudi
KDM1 is a novel therapeutic target for the treatment of gliomas.
Pavlos Fanis; Nynke Gillemans; Frank Grosveld; Sjaak Philipsen; Farzin Pourfarzad; Ratna K Vadlamudi; Ali Aghajanirefah; Jeroen A A Demmers; Fatemehsadat Esteghamat; Thamar B van Dijk
Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation.

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2013: Quan-Guang Zhang; Yan Dong; Dong Han; Gangadhara Reddy Sareddy; Erin Scott; Jing-Yi Tu; Ratna K Vadlamudi; Rui-Min Wang; Fang Yang; Darrell W Brann
Hypersensitivity of the hippocampal CA3 region to stress-induced neurodegeneration and amyloidogenesis in a rat model of surgical menopause.
Brain : a journal of neurology 2013;136(Pt 5):1432-45.
2013: Gangadhara R Sareddy; Takayoshi Suzuki; Quan-guang Zhang; Darrell W Brann; Andrew J Brenner; Vijay K Gonugunta; Samaya K Krishnan; Naoki Miyata; Binoj C Nair; Ratna K Vadlamudi
KDM1 is a novel therapeutic target for the treatment of gliomas.
Oncotarget 2013;4(1):18-28.
2012: Pavlos Fanis; Nynke Gillemans; Frank Grosveld; Sjaak Philipsen; Farzin Pourfarzad; Ratna K Vadlamudi; Ali Aghajanirefah; Jeroen A A Demmers; Fatemehsadat Esteghamat; Thamar B van Dijk
Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation.
Molecular & cellular proteomics : MCP 2012;11(11):1263-73.
2012: Gangadhara R Sareddy; Rajeshwar Tekmal; Quan-guang Zhang; Darrell W Brann; Andrew Brenner; Vijay K Gonugunta; Binoj C Nair; Ratna K Vadlamudi
Therapeutic significance of estrogen receptor β agonists in gliomas.
Molecular cancer therapeutics 2012;11(5):1174-82.
2012: Hareesh B Nair; Sujit S Nair; Rao P Perla; Rajib Rajhans; Pothana Saikumar; Manonmani Ganapathy; Nameer Kirma; Naveen K Krishnegowda; Ratna K Vadlamudi; Rajeshwar Tekmal
Estrogen receptor-beta mediates the protective effects of aromatase induction in the MMTV-Her-2/neu x aromatase double transgenic mice.
Hormones & cancer 2012;3(1-2):26-36.
2012: M Mann; S Krishnan; Ratna K Vadlamudi
Emerging significance of estrogen cancer coregulator signaling in breast cancer.
Minerva ginecologica 2012;64(1):75-88.
2012: J Saadi Imam; Subbarayalu Panneerdoss; Alexander Pertsemlidis; Jason R Plyler; Suresh Prajapati; Jennifer Rebeles; Gail Tomlinson; Ratna K Vadlamudi; Behyar Zoghi; Hima Bansal; Sanjay Bansal; Russell Broaddus; Kalyan C Buddavarapu; Yao-Fu Chang; Hung-I Harry Chen; Yidong Chen; Jeffrey Dome; Peter Hornsby; Manjeet K Rao
Genomic loss of tumor suppressor miRNA-204 promotes cancer cell migration and invasion by activating AKT/mTOR/Rac1 signaling and actin reorganization.
PloS one 2012;7(12):e52397.
2012: Sudipa Saha Roy; Ratna K Vadlamudi
Role of estrogen receptor signaling in breast cancer metastasis.
International journal of breast cancer 2012;2012():654698.
2012: Sudipa Roy; Luzhe Sun; Rajeshwar Tekmal; Jung-Mo Ahn; Abhik Bandyopadhyay; Dimple Chakravarty; Valerie Cortez; Keya De Mukhopadhyay; Ganesh V Raj; Ratna K Vadlamudi
Significance of PELP1 in ER-negative breast cancer metastasis.
Molecular cancer research : MCR 2012;10(1):25-33.
2012: Erin Scott; Ratna K Vadlamudi; Ruimin Wang; Quan-guang Zhang; Darrell W Brann
Estrogen neuroprotection and the critical period hypothesis.
Frontiers in neuroendocrinology 2012;33(1):85-104.
2012: Darrell W Brann; Ratna K Vadlamudi; L Raz; R Wang; Q Zhang
Oestrogen signalling and neuroprotection in cerebral ischaemia.
Journal of neuroendocrinology 2012;24(1):34-47.
2011: Sreeram Vallabhaneni; Dimple Chakravarty; Rambabu Challa; Valerie Cortez; Binoj C Nair; Rajeshwar Tekmal; Ratna K Vadlamudi
Significance of ER-Src axis in hormonal therapy resistance.
Breast cancer research and treatment 2011;130(2):377-85.
2011: Quanguang Zhang; Yan Dong; Dong Han; Ratna K Vadlamudi; Rui-min Wang; Fang Yang; Darrell W Brann
C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(35):E617-24.
2011: Hareesh B Nair; Manonmani Ganapathy; Nameer Kirma; Ratna K Vadlamudi; Rajeshwar Tekmal
Estrogen receptor-β activation in combination with letrozole blocks the growth of breast cancer tumors resistant to letrozole therapy.
Steroids 2011;76(8):792-6.
2011: Dimple Chakravarty; Sudipa Saha Roy; Challa Ram Babu; Rajasekhar Dandamudi; Tyler J Curiel; Pablo Vivas-Mejia; Gabriel Lopez-Berestein; Anil K Sood; Ratna K Vadlamudi
Therapeutic targeting of PELP1 prevents ovarian cancer growth and metastasis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(8):2250-9.
2011: Binoj C Nair; Rajeshwar Tekmal; Sreeram Vallabhaneni; Ratna K Vadlamudi
Roscovitine confers tumor suppressive effect on therapy-resistant breast tumor cells.
Breast cancer research : BCR 2011;13(3):R80.
2011: Vijay K Gonugunta; Binoj C Nair; Sujit S Nair; Rajib Rajhans; Gangadhara R Sareddy; Ratna K Vadlamudi
Regulation of rDNA transcription by proto-oncogene PELP1.
PloS one 2011;6(6):e21095.
2011: Valerie Cortez; Binoj C Nair; Dimple Chakravarty; Ratna K Vadlamudi
Integrin-linked kinase 1: role in hormonal cancer progression.
Frontiers in bioscience (Scholar edition) 2011;3():788-96.
2010: V Cortez; M Mann; Darrell W Brann; Ratna K Vadlamudi
Extranuclear signaling by estrogen: role in breast cancer progression and metastasis.
Minerva ginecologica 2010;62(6):573-83.
2010: Binoj C Nair; Sujit S Nair; Dimple Chakravarty; Rambabu Challa; Bramanandam Manavathi; Patricia Yew; Rakesh Kumar; Rajeshwar Tekmal; Ratna K Vadlamudi
Cyclin-dependent kinase-mediated phosphorylation plays a critical role in the oncogenic functions of PELP1.
Cancer research 2010;70(18):7166-75.
2010: Pei-Yi Lin; Lishi Sun; Suzanne R Thibodeaux; Sara M Ludwig; Ratna K Vadlamudi; vincent hurez; Rumana Bahar; Mark J Kious; Carolina B Livi; Shawna R Wall; Lieping Chen; Bin Zhang; Tae Kwang Shin; Tyler J Curiel
B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(5):2747-53.
2010: Sujit S Nair; Binoj C Nair; Valerie Cortez; Dimple Chakravarty; Eric Metzger; Roland Schüle; Darrell W Brann; Rajeshwar Tekmal; Ratna K Vadlamudi
PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor-alpha target gene activation by regulating lysine demethylase 1 specificity.
EMBO reports 2010;11(6):438-44.
2010: Dimple Chakravarty; Sujit S Nair; Bindu Santhamma; Binoj C Nair; Long Wang; Abhik Bandyopadhyay; Joseph Agyin; Darrell W Brann; Luzhe Sun; I-Tien Yeh; Francis Y Lee; Rajeshwar Tekmal; Rakesh Kumar; Ratna K Vadlamudi
Extranuclear functions of ER impact invasive migration and metastasis by breast cancer cells.
Cancer research 2010;70(10):4092-101.
2010: Binoj C Nair; Ratna K Vadlamudi
ZD6474 coerces breast cancer for an apoptotic journey.
Cancer biology & therapy 2010;9(8):604-6.
2010: Dimple Chakravarty; Rajeshwar Tekmal; Ratna K Vadlamudi
PELP1: A novel therapeutic target for hormonal cancers.
IUBMB life 2010;62(3):162-9.
2010: Ratna K Vadlamudi; Rajib Rajhans; Dimple Chakravarty; Binoj C Nair; Sujit S Nair; Dean B Evans; Shiuan Chen; Rajeshwar Tekmal
Regulation of aromatase induction by nuclear receptor coregulator PELP1.
The Journal of steroid biochemistry and molecular biology 2010;118(4-5):211-8.
2009: Quanguang Zhang; Limor Raz; Ruimin Wang; Dong Han; Liesl M De Sevilla; Fang Yang; Ratna K Vadlamudi; Darrell W Brann
Estrogen attenuates ischemic oxidative damage via an estrogen receptor alpha-mediated inhibition of NADPH oxidase activation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(44):13823-36.
2009: Vladimir M Popov; Jie Zhou; L Andrew Shirley; Judy Quong; Wen-Shuz Yeow; Jennifer A Wright; Kongming Wu; Hallgeir Rui; Ratna K Vadlamudi; Jie Jiang; Rakesh Kumar; Chenguang Wang; Richard G Pestell
The cell fate determination factor DACH1 is expressed in estrogen receptor-alpha-positive breast cancer and represses estrogen receptor-alpha signaling.
Cancer research 2009;69(14):5752-60.
2009: Rakesh Kumar; Hao Zhang; Caroline Holm; Ratna K Vadlamudi; Goran Landberg; Suresh K Rayala
Extranuclear coactivator signaling confers insensitivity to tamoxifen.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(12):4123-30.
2008: Midori Kayahara; Jacqueline Ohanian; Vasken Ohanian; Andrew Berry; Ratna K Vadlamudi; David W Ray
MNAR functionally interacts with both NH2- and COOH-terminal GR domains to modulate transactivation.
American journal of physiology. Endocrinology and metabolism 2008;295(5):E1047-55.
2008: Darrell W Brann; Quanguang Zhang; Rui-Min Wang; Virendra B Mahesh; Ratna K Vadlamudi
PELP1--a novel estrogen receptor-interacting protein.
Molecular and cellular endocrinology 2008;290(1-2):2-7.
2008: Chakravarty Dimple; Sujit S Nair; Rajib Rajhans; Perla R Pitcheswara; Jinsong Liu; Seetharaman Balasenthil; Xiao-Feng Le; Matthew Burow; Nelly Auersperg; Rajeshwar Tekmal; Russell R Broaddus; Ratna K Vadlamudi
Role of PELP1/MNAR signaling in ovarian tumorigenesis.
Cancer research 2008;68(12):4902-9.
2008: JATIN NAGPAL; Sujit Nair; Dimple Chakravarty; Rajib Rajhans; Saikumar Pothana; Darrell W Brann; Rajeshwar Tekmal; Ratna K Vadlamudi
Growth factor regulation of estrogen receptor coregulator PELP1 functions via Protein Kinase A pathway.
Molecular cancer research : MCR 2008;6(5):851-61.
2008: Rajib Rajhans; Hareesh B. Nair; Sujit S Nair; Valerie Cortez; Kijima Ikuko; Nameer Kirma; Dujin Zhou; Alan EC Holden; Darrell W Brann; Shiuan Chen; Rajeshwar Tekmal; Ratna K Vadlamudi
Modulation of in situ estrogen synthesis by proline-, glutamic acid-, and leucine-rich protein-1: potential estrogen receptor autocrine signaling loop in breast cancer cells.
Molecular endocrinology (Baltimore, Md.) 2008;22(3):649-64.
2008: Limor Raz; Mohammad M Khan; Virendra B Mahesh; Ratna K Vadlamudi; Darrell W Brann
Rapid estrogen signaling in the brain.
Neuro-Signals 2008;16(2-3):140-53.
2007: Kazufumi Ohshiro; Rayala Suresh; Seiji Kondo; Amitabh Gaur; Ratna K Vadlamudi; Adel K El-Naggar; Rakesh Kumar
Identifying the estrogen receptor coactivator PELP1 in autophagosomes.
Cancer research 2007;67(17):8164-71.
2007: Anupama E Gururaj; Shaohua Peng; Ratna K Vadlamudi; Rakesh Kumar
Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1).
Molecular endocrinology (Baltimore, Md.) 2007;21(8):1847-60.
2007: Rajib Rajhans; Sujit Nair; Alan EC Holden; Rakesh Kumar; Rajeshwar Tekmal; Ratna K Vadlamudi
Oncogenic potential of the nuclear receptor coregulator proline-, glutamic acid-, leucine-rich protein 1/modulator of the nongenomic actions of the estrogen receptor.
Cancer research 2007;67(11):5505-12.
2007: Sujit S Nair; Zhiyong Guo; Judith M Mueller; Shahriar Koochekpour; Yun Qiu; Rajeshwar Tekmal; Roland Schüle; Hsing-Jien Kung; Rakesh Kumar; Ratna K Vadlamudi
Proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor enhances androgen receptor functions through LIM-only coactivator, four-and-a-half LIM-only protein 2.
Molecular endocrinology (Baltimore, Md.) 2007;21(3):613-24.
2007: Ratna K Vadlamudi; Rakesh Kumar
Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR.
Nuclear receptor signaling 2007;5():e004.
2007: S Nair; Ratna K Vadlamudi
Emerging significance of ER-coregulator PELP1/MNAR in cancer.
Histology and histopathology 2007;22(1):91-6.
2006: Yun Zhu; Lacey L Sullivan; Sujit S Nair; Christopher C Williams; Arvind K Pandey; Luis Marrero; Ratna K Vadlamudi; Frank E Jones
Coregulation of estrogen receptor by ERBB4/HER4 establishes a growth-promoting autocrine signal in breast tumor cells.
Cancer research 2006;66(16):7991-8.
2006: Rajesh R Singh; Anupama E Gururaj; Ratna K Vadlamudi; Rakesh Kumar
9-cis-retinoic acid up-regulates expression of transcriptional coregulator PELP1, a novel coactivator of the retinoid X receptor alpha pathway.
The Journal of biological chemistry 2006;281(22):15394-404.
2006: Rayala Suresh; Petra den Hollander; Seetharaman Balasenthil; Poonam R Molli; Andrew J Bean; Ratna K Vadlamudi; Rui-An Wang; Rakesh Kumar
Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) interacts with PELP1 and activates MAPK.
The Journal of biological chemistry 2006;281(7):4395-403.
2006: Rayala Suresh; Joseph Mascarenhas; Ratna K Vadlamudi; Rakesh Kumar
Altered localization of a coactivator sensitizes breast cancer cells to tumor necrosis factor-induced apoptosis.
Molecular cancer therapeutics 2006;5(2):230-7.
2006: Anupama E Gururaj; Rayala Suresh; Ratna K Vadlamudi; Rakesh Kumar
Novel mechanisms of resistance to endocrine therapy: genomic and nongenomic considerations.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(3 Pt 2):1001s-1007s.
2006: Rajib Rajhans; Ratna K Vadlamudi
Comprehensive analysis of recent biochemical and biologic findings regarding a newly discovered protein-PELP1/MNAR.
Clinical & experimental metastasis 2006;23(1):1-7.
2005: Mohammad M Khan; Martin Hadman; Chandramohan Wakade; Liesl M De Sevilla; Krishnan Michael Dhandapani; Virendra B Mahesh; Ratna K Vadlamudi; Darrell W Brann
Cloning, expression, and localization of MNAR/PELP1 in rodent brain: colocalization in estrogen receptor-alpha- but not in gonadotropin-releasing hormone-positive neurons.
Endocrinology 2005;146(12):5215-27.
2005: Ratna K Vadlamudi; Bramanandam Manavathi; Seetharaman Balasenthil; Sujit S Nair; Zhibo Yang; Aysegul A Sahin; Rakesh Kumar
Functional implications of altered subcellular localization of PELP1 in breast cancer cells.
Cancer research 2005;65(17):7724-32.
2005: Bramanandam Manavathi; Sujit S Nair; Rui-An Wang; Rakesh Kumar; Ratna K Vadlamudi
Proline-, glutamic acid-, and leucine-rich protein-1 is essential in growth factor regulation of signal transducers and activators of transcription 3 activation.
Cancer research 2005;65(13):5571-7.
2005: Ratna K Vadlamudi; Bramanandam Manavathi; Rajesh R Singh; Diep Nguyen; Feng Li; Rakesh Kumar
An essential role of Pak1 phosphorylation of SHARP in Notch signaling.
Oncogene 2005;24(28):4591-6.
2005: Ratna K Vadlamudi; Seetharaman Balasenthil; Aysegul A Sahin; Merrill S Kies; Randal S Weber; Rakesh Kumar; Adel K El-Naggar
Novel estrogen receptor coactivator PELP1/MNAR gene and ERbeta expression in salivary duct adenocarcinoma: potential therapeutic targets.
Human pathology 2005;36(6):670-5.
2005: Ratna K Vadlamudi; Christopher J Barnes; Rayala Suresh; Feng Li; Seetharaman Balasenthil; Stevan Marcus; Holly V Goodson; Aysegul A Sahin; Rakesh Kumar
p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B.
Molecular and cellular biology 2005;25(9):3726-36.
2005: Rakesh Kumar; Anupama E Gururaj; Ratna K Vadlamudi; Rayala Suresh
The clinical relevance of steroid hormone receptor corepressors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(8):2822-31.
2005: Zhibo Yang; Rayala Suresh; Diep Nguyen; Ratna K Vadlamudi; Shiuan Chen; Rakesh Kumar
Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functions.
Cancer research 2005;65(8):3179-84.
2005: Zhibo Yang; Ratna K Vadlamudi; Rakesh Kumar
Dynein light chain 1 phosphorylation controls macropinocytosis.
The Journal of biological chemistry 2005;280(1):654-9.
2004: Ratna K Vadlamudi; Seetharaman Balasenthil; Russell R Broaddus; Jan-�ke GUSTAFSSON; Rakesh Kumar
Deregulation of estrogen receptor coactivator proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor in human endometrial tumors.
The Journal of clinical endocrinology and metabolism 2004;89(12):6130-8.
2004: Anupama E Gururaj; Christopher J Barnes; Ratna K Vadlamudi; Rakesh Kumar
Regulation of phosphoglucomutase 1 phosphorylation and activity by a signaling kinase.
Oncogene 2004;23(49):8118-27.
2004: Sujit S Nair; Sandip K Mishra; Zhibo Yang; Seetharaman Balasenthil; Rakesh Kumar; Ratna K Vadlamudi
Potential role of a novel transcriptional coactivator PELP1 in histone H1 displacement in cancer cells.
Cancer research 2004;64(18):6416-23.
2004: Amjad H Talukder; Anupama E Gururaj; Sandip K Mishra; Ratna K Vadlamudi; Rakesh Kumar
Metastasis-associated protein 1 interacts with NRIF3, an estrogen-inducible nuclear receptor coregulator.
Molecular and cellular biology 2004;24(15):6581-91.
2004: Sandip K Mishra; Amjad H Talukder; Anupama E Gururaj; Zhibo Yang; Rajesh R Singh; My G Mahoney; Clara Francí; Ratna K Vadlamudi; Rakesh Kumar
Upstream determinants of estrogen receptor-alpha regulation of metastatic tumor antigen 3 pathway.
The Journal of biological chemistry 2004;279(31):32709-15.
2004: Rozita Bagheri-Yarmand; Amjad H Talukder; Rui-An Wang; Ratna K Vadlamudi; Rakesh Kumar
Metastasis-associated protein 1 deregulation causes inappropriate mammary gland development and tumorigenesis.
Development (Cambridge, England) 2004;131(14):3469-79.
2004: Ratna K Vadlamudi; Rozita Bagheri-Yarmand; Zhibo Yang; Seetharaman Balasenthil; Diep Nguyen; Aysegul A Sahin; Petra den Hollander; Rakesh Kumar
Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes.
Cancer cell 2004;5(6):575-85.
2004: Sandip K Mishra; Seetharaman Balasenthil; Diep Nguyen; Ratna K Vadlamudi
Cloning and functional characterization of PELP1/MNAR promoter.
Gene 2004;330():115-22.
2004: Christopher J Barnes; Ratna K Vadlamudi; R Kumar
Novel estrogen receptor coregulators and signaling molecules in human diseases.
Cellular and molecular life sciences : CMLS 2004;61(3):281-91.
2004: Ratna K Vadlamudi; Feng Li; Christopher J Barnes; Rozita Bagheri-Yarmand; Rakesh Kumar
p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate.
EMBO reports 2004;5(2):154-60.
2004: Seetharaman Balasenthil; Aysegul A Sahin; Christopher J Barnes; Rui-An Wang; Richard G Pestell; Ratna K Vadlamudi; Rakesh Kumar
p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells.
The Journal of biological chemistry 2004;279(2):1422-8.
2004: Ratna K Vadlamudi; Rakesh Kumar
p21-activated kinase 1: an emerging therapeutic target.
Cancer treatment and research 2004;119():77-88.
2003: Ratna K Vadlamudi; Rakesh Kumar
P21-activated kinases in human cancer.
Cancer metastasis reviews 2003;22(4):385-93.
2003: Christopher J Barnes; Ratna K Vadlamudi; Sandip K Mishra; Raymond Jacobsonr; Feng Li; Rakesh Kumar
Functional inactivation of a transcriptional corepressor by a signaling kinase.
Nature structural biology 2003;10(8):622-8.
2003: Seetharaman Balasenthil; Ratna K Vadlamudi
Functional interactions between the estrogen receptor coactivator PELP1/MNAR and retinoblastoma protein.
The Journal of biological chemistry 2003;278(24):22119-27.
2003: Sandip K Mishra; Abhijit Mazumdar; Ratna K Vadlamudi; Feng Li; Rui-An Wang; Wei Yu; V Craig Jordan; Richard J Santen; Rakesh Kumar
MICoA, a novel metastasis-associated protein 1 (MTA1) interacting protein coactivator, regulates estrogen receptor-alpha transactivation functions.
The Journal of biological chemistry 2003;278(21):19209-19.
2003: Ratna K Vadlamudi; Aysegul A Sahin; Liana Adam; Rui-An Wang; Rakesh Kumar
Heregulin and HER2 signaling selectively activates c-Src phosphorylation at tyrosine 215.
FEBS letters 2003;543(1-3):76-80.
2003: Rui-An Wang; Ratna K Vadlamudi; Rozita Bagheri-Yarmand; Iwan Beuvink; Nancy E Hynes; Rakesh Kumar
Essential functions of p21-activated kinase 1 in morphogenesis and differentiation of mammary glands.
The Journal of cell biology 2003;161(3):583-92.
2003: Rozita Bagheri-Yarmand; Ratna K Vadlamudi; Rakesh Kumar
Activating transcription factor 4 overexpression inhibits proliferation and differentiation of mammary epithelium resulting in impaired lactation and accelerated involution.
The Journal of biological chemistry 2003;278(19):17421-9.
2002: Rakesh Kumar; Ratna K Vadlamudi
Emerging functions of p21-activated kinases in human cancer cells.
Journal of cellular physiology 2002;193(2):133-44.
2002: Rui-An Wang; Abhijit Mazumdar; Ratna K Vadlamudi; Rakesh Kumar
P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium.
The EMBO journal 2002;21(20):5437-47.
2002: J A Dorsch; Mehmet Candas; Natalya B Griko; W S A Maaty; Eric G Midboe; Ratna K Vadlamudi; Lee A Bulla
Cry1A toxins of Bacillus thuringiensis bind specifically to a region adjacent to the membrane-proximal extracellular domain of BT-R(1) in Manduca sexta: involvement of a cadherin in the entomopathogenicity of Bacillus thuringiensis.
Insect biochemistry and molecular biology 2002;32(9):1025-36.
2002: Ratna K Vadlamudi; Feng Li; Liana Adam; Diep Nguyen; Yasutaka Ohta; Thomas P Stossel; Rakesh Kumar
Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1.
Nature cell biology 2002;4(9):681-90.
2002: Rakesh Kumar; Rui-An Wang; Abhijit Mazumdar; Amjad H Talukder; Mahitosh Mandal; Zhibo Yang; Rozita Bagheri-Yarmand; Aysegul Sahin; Gabriel Hortobagyi; Liana Adam; Christopher J Barnes; Ratna K Vadlamudi
A naturally occurring MTA1 variant sequesters oestrogen receptor-alpha in the cytoplasm.
Nature 2002;418(6898):654-7.
2002: Feng Li; Liana Adam; Ratna K Vadlamudi; Hongyi Zhou; Subrata Sen; Jonathan Chernoff; Mahitosh Mandal; Rakesh Kumar
p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells.
EMBO reports 2002;3(8):767-73.
2002: Ratna K Vadlamudi; Liana Adam; Diep Nguyen; Manes Santos; Rakesh Kumar
Differential regulation of components of the focal adhesion complex by heregulin: role of phosphatase SHP-2.
Journal of cellular physiology 2002;190(2):189-99.
2001: Feng Li; Mahitosh Mandal; Christopher J Barnes; Ratna K Vadlamudi; Rakesh Kumar
Growth factor regulation of the molecular chaperone calnexin.
Biochemical and biophysical research communications 2001;289(3):725-32.
2001: Ratna K Vadlamudi; Rui-An Wang; Abhijit Mazumdar; Youngchang Kim; J Shin; Aysegul Sahin; Rakesh Kumar
Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha.
The Journal of biological chemistry 2001;276(41):38272-9.
2001: Rozita Bagheri-Yarmand; Mahitosh Mandal; A H Taludker; Rui-An Wang; Ratna K Vadlamudi; Hsing-Jien Kung; Rakesh Kumar
Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells.
The Journal of biological chemistry 2001;276(31):29403-9.
2001: Liana Adam; Ratna K Vadlamudi; Pierre D McCrea; Rakesh Kumar
Tiam1 overexpression potentiates heregulin-induced lymphoid enhancer factor-1/beta -catenin nuclear signaling in breast cancer cells by modulating the intercellular stability.
The Journal of biological chemistry 2001;276(30):28443-50.
2001: Mahitosh Mandal; Ratna K Vadlamudi; Diep Nguyen; Rui-An Wang; L Costa; Rozita Bagheri-Yarmand; John Mendelsohn; Rakesh Kumar
Growth factors regulate heterogeneous nuclear ribonucleoprotein K expression and function.
The Journal of biological chemistry 2001;276(13):9699-704.
2001: Amjad H Talukder; HF Jorgensen; Mahitosh Mandal; Sandip K Mishra; Ratna K Vadlamudi; Brian F C Clark; John Mendelsohn; Rakesh Kumar
Regulation of elongation factor-1alpha expression by growth factors and anti-receptor blocking antibodies.
The Journal of biological chemistry 2001;276(8):5636-42.
2001: Mahitosh Mandal; D J Olson; T Sharma; Ratna K Vadlamudi; Rakesh Kumar
Butyric acid induces apoptosis by up-regulating Bax expression via stimulation of the c-Jun N-terminal kinase/activation protein-1 pathway in human colon cancer cells.
Gastroenterology 2001;120(1):71-8.
2001: Abhijit Mazumdar; Rui-An Wang; Sandip K Mishra; Liana Adam; Rozita Bagheri-Yarmand; Mahitosh Mandal; Ratna K Vadlamudi; Rakesh Kumar
Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor.
Nature cell biology 2001;3(1):30-7.
2000: Rozita Bagheri-Yarmand; Ratna K Vadlamudi; Rui-An Wang; John Mendelsohn; Rakesh Kumar
Vascular endothelial growth factor up-regulation via p21-activated kinase-1 signaling regulates heregulin-beta1-mediated angiogenesis.
The Journal of biological chemistry 2000;275(50):39451-7.
2000: Rakesh Kumar; Mahitosh Mandal; Ratna K Vadlamudi
New insights into anti-HER-2 receptor monoclonal antibody research.
Seminars in oncology 2000;27(6 Suppl 11):84-91; discussion 92-100.
2000: R Kumar; Ratna K Vadlamudi; Liana Adam
Apoptosis in mammary gland and cancer.
Endocrine-related cancer 2000;7(4):257-69.
2000: Ratna K Vadlamudi; Rui-An Wang; Amjad H Talukder; Liana Adam; R Johnson; Rakesh Kumar
Evidence of Rab3A expression, regulation of vesicle trafficking, and cellular secretion in response to heregulin in mammary epithelial cells.
Molecular and cellular biology 2000;20(23):9092-101.
2000: Ratna K Vadlamudi; Liana Adam; Rui-An Wang; Mahitosh Mandal; Diep Nguyen; Aysegul Sahin; Jonathan Chernoff; Mien-Chie Hung; Rakesh Kumar
Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells.
The Journal of biological chemistry 2000;275(46):36238-44.
2000: Xiao-Feng Le; Ratna K Vadlamudi; Amanda McWatters; D S Bae; Gordon B Mills; Rakesh Kumar; Robert C Bast
Differential signaling by an anti-p185(HER2) antibody and heregulin.
Cancer research 2000;60(13):3522-31.
2000: Liana Adam; Ratna K Vadlamudi; Mahitosh Mandal; Jonathan Chernoff; Rakesh Kumar
Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1.
The Journal of biological chemistry 2000;275(16):12041-50.
2000: Amjad H Talukder; Ratna K Vadlamudi; Mahitosh Mandal; Rakesh Kumar
Heregulin induces expression, DNA binding activity, and transactivating functions of basic leucine zipper activating transcription factor 4.
Cancer research 2000;60(2):276-81.
1999: Ratna K Vadlamudi; Liana Adam; Amjad H Talukder; John Mendelsohn; Rakesh Kumar
Serine phosphorylation of paxillin by heregulin-beta1: role of p38 mitogen activated protein kinase.
Oncogene 1999;18(51):7253-64.
1999: Ratna K Vadlamudi; Liana Adam; B Tseng; L Costa; Rakesh Kumar
Transcriptional up-regulation of paxillin expression by heregulin in human breast cancer cells.
Cancer research 1999;59(12):2843-6.
1999: Ratna K Vadlamudi; Mahitosh Mandal; Liana Adam; G Steinbach; John Mendelsohn; Rakesh Kumar
Regulation of cyclooxygenase-2 pathway by HER2 receptor.
Oncogene 1999;18(2):305-14.
1998: Liana Adam; Ratna K Vadlamudi; S B Kondapaka; Jonathan Chernoff; John Mendelsohn; Rakesh Kumar
Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase.
The Journal of biological chemistry 1998;273(43):28238-46.
1998: Ratna K Vadlamudi; J Shin
Genomic structure and promoter analysis of the p62 gene encoding a non-proteasomal multiubiquitin chain binding protein.
FEBS letters 1998;435(2-3):138-42.
1996: Ratna K Vadlamudi; I Joung; Jack L Strominger; J Shin
p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins.
The Journal of biological chemistry 1996;271(34):20235-7.
1995: Ratna K Vadlamudi; E Weber; Inhae Ji; Tae H Ji; Lee A Bulla
Cloning and expression of a receptor for an insecticidal toxin of Bacillus thuringiensis.
The Journal of biological chemistry 1995;270(10):5490-4.
1994: C J Belfiore; Ratna K Vadlamudi; Y A Osman; Lee A Bulla
A specific binding protein from Tenebrio molitor for the insecticidal toxin of Bacillus thuringiensis subsp. tenebrionis.
Biochemical and biophysical research communications 1994;200(1):359-64.
1993: S D Zimmerman; Richard J McCormick; Ratna K Vadlamudi; D Paul Thomas
Age and training alter collagen characteristics in fast- and slow-twitch rat limb muscle.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;75(4):1670-4.
1993: Ratna K Vadlamudi; Tae H Ji; Lee A Bulla
A specific binding protein from Manduca sexta for the insecticidal toxin of Bacillus thuringiensis subsp. berliner.
The Journal of biological chemistry 1993;268(17):12334-40.
1993: Ratna K Vadlamudi; Richard J McCormick; Denis M Medeiros; J Vossoughi; M L Failla
Copper deficiency alters collagen types and covalent cross-linking in swine myocardium and cardiac valves.
The American journal of physiology 1993;264(6 Pt 2):H2154-61.
1992: D Paul Thomas; Richard J McCormick; S D Zimmerman; Ratna K Vadlamudi; L E Gosselin
Aging- and training-induced alterations in collagen characteristics of rat left ventricle and papillary muscle.
The American journal of physiology 1992;263(3 Pt 2):H778-83.