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Nick Holford

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TOP 3
Nick Holford
Modeling helps in understanding antidepressants.
Thuy C Vu; John G Nutt; Nick Holford
Disease progress and response to treatment as predictors of survival, disability, cognitive impairment and depression in Parkinson's disease.
Thuy C Vu; John G Nutt; Nick Holford
Progression of motor and nonmotor features of Parkinson's disease and their response to treatment.

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All Publications

2012: Nick Holford
Modeling helps in understanding antidepressants.
Clinical pharmacology and therapeutics 2012;92(2):155-6.
2012: Thuy C Vu; John G Nutt; Nick Holford
Disease progress and response to treatment as predictors of survival, disability, cognitive impairment and depression in Parkinson's disease.
British journal of clinical pharmacology 2012;74(2):284-95.
2012: Thuy C Vu; John G Nutt; Nick Holford
Progression of motor and nonmotor features of Parkinson's disease and their response to treatment.
British journal of clinical pharmacology 2012;74(2):267-83.
2011: Nick Holford
Holford NHG and Sheiner LB "Understanding the Dose-Effect Relationship-Clinical Application of Pharmacokinetic-Pharmacodynamic Models", Clin Pharmacokin 6:429-453 (1981)-The Backstory.
The AAPS journal 2011;13(4):662-4.
2011: Brian Anderson; Nick Holford
Evaluation of a morphine maturation model for the prediction of morphine clearance in children.
British journal of clinical pharmacology 2011;72(3):518-20; author reply 521-3.
2011: Anita L Sumpter; Nick Holford
Predicting weight using postmenstrual age--neonates to adults.
Paediatric anaesthesia 2011;21(3):309-15.
2011: Brian J Anderson; Nick Holford
Tips and traps analyzing pediatric PK data.
Paediatric anaesthesia 2011;21(3):222-37.
2010: Nick Holford; S C Ma; B A Ploeger
Clinical trial simulation: a review.
Clinical pharmacology and therapeutics 2010;88(2):166-82.
2010: Amanda L Potts; Brian J Anderson; Nick Holford; Thuy C Vu; Guy R Warman
Dexmedetomidine hemodynamics in children after cardiac surgery.
Paediatric anaesthesia 2010;20(5):425-33.
2010: Nick Holford
Dosing in children.
Clinical pharmacology and therapeutics 2010;87(3):367-70.
2008: Lai-San Tham; Ling-Zhi Wang; Ross Soo; How-Sung Lee; Soo-Chin Lee; Boon Cher Goh; Nick Holford
Does saturable formation of gemcitabine triphosphate occur in patients?
Cancer chemotherapy and pharmacology 2008;63(1):55-64.
2008: Lai-San Tham; Lingzhi Wang; Ross Soo; Soo-Chin Lee; How-Sung Lee; Wei-Peng Yong; Boon Cher Goh; Nick Holford
A pharmacodynamic model for the time course of tumor shrinkage by gemcitabine + carboplatin in non-small cell lung cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(13):4213-8.
2008: Nick Holford; John G Nutt
Disease progression, drug action and Parkinson's disease: why time cannot be ignored.
European journal of clinical pharmacology 2008;64(2):207-16.
2008: David W Herd; Brian J Anderson; Natalie A Keene; Nick Holford
Investigating the pharmacodynamics of ketamine in children.
Paediatric anaesthesia 2008;18(1):36-42.
2008: B J Anderson; Nick Holford
Mechanism-based concepts of size and maturity in pharmacokinetics.
Annual review of pharmacology and toxicology 2008;48():303-32.
2007: Lai-San Tham; Nick Holford; Sok-Ying Hor; Theresa Tan; Lingzhi Wang; Rui-Chen Lim; How-Sung Lee; Soo-Chin Lee; Boon Cher Goh
Lack of association of single-nucleotide polymorphisms in pregnane X receptor, hepatic nuclear factor 4alpha, and constitutive androstane receptor with docetaxel pharmacokinetics.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(23):7126-32.
2007: David W Herd; Brian J Anderson; Nick Holford
Modeling the norketamine metabolite in children and the implications for analgesia.
Paediatric anaesthesia 2007;17(9):831-40.
2007: Nick Holford; M O Karlsson
Time for quantitative clinical pharmacology: a proposal for a pharmacometrics curriculum.
Clinical pharmacology and therapeutics 2007;82(1):103-5.
2007: Phylinda L S Chan; John G Nutt; Nick Holford
Levodopa slows progression of Parkinson's disease: external validation by clinical trial simulation.
Pharmaceutical research 2007;24(4):791-802.
2007: Lanyan Fang; Nick Holford; George Hinkle; Xianhua Cao; Jim J Xiao; Mark Bloomston; Seth Gibbs; Osama Habib Al Saif; James T Dalton; Kenneth K Chan; Jeffery Schlom; Edward W Martin; Duxin Sun
Population pharmacokinetics of humanized monoclonal antibody HuCC49deltaCH2 and murine antibody CC49 in colorectal cancer patients.
Journal of clinical pharmacology 2007;47(2):227-37.
2007: Brian J Anderson; Karel Allegaert; John N van den Anker; Veerle Cossey; Nick Holford
Vancomycin pharmacokinetics in preterm neonates and the prediction of adult clearance.
British journal of clinical pharmacology 2007;63(1):75-84.
2006: Stacey J Tannenbaum; Nick Holford; Howard Lee; Carl C Peck; Diane R Mould
Simulation of correlated continuous and categorical variables using a single multivariate distribution.
Journal of pharmacokinetics and pharmacodynamics 2006;33(6):773-94.
2006: Brian J Anderson; Karel Allegaert; Nick Holford
Population clinical pharmacology of children: modelling covariate effects.
European journal of pediatrics 2006;165(12):819-29.
2006: Brian J Anderson; Karel Allegaert; Nick Holford
Population clinical pharmacology of children: general principles.
European journal of pediatrics 2006;165(11):741-6.
2006: Nick Holford; Phylinda L S Chan; John G Nutt; Karl Kieburtz; Ira Shoulson
Disease progression and pharmacodynamics in Parkinson disease - evidence for functional protection with levodopa and other treatments.
Journal of pharmacokinetics and pharmacodynamics 2006;33(3):281-311.
2006: Karel Allegaert; Brian J Anderson; Veerle Cossey; Nick Holford
Limited predictability of amikacin clearance in extreme premature neonates at birth.
British journal of clinical pharmacology 2006;61(1):39-48.
2005: Phylinda L S Chan; John G Nutt; Nick Holford
Pharmacokinetic and pharmacodynamic changes during the first four years of levodopa treatment in Parkinson's disease.
Journal of pharmacokinetics and pharmacodynamics 2005;32(3-4):459-84.
2005: Phylinda L S Chan; John G Nutt; Nick Holford
Importance of within subject variation in levodopa pharmacokinetics: a 4 year cohort study in Parkinson's disease.
Journal of pharmacokinetics and pharmacodynamics 2005;32(3-4):307-31.
2005: Stephen B Duffull; Carl M J Kirkpatrick; Bruce Green; Nick Holford
Analysis of population pharmacokinetic data using NONMEM and WinBUGS.
Journal of biopharmaceutical statistics 2005;15(1):53-73.
2004: Ivan Matthews; Carl Kirkpatrick; Nick Holford
Quantitative justification for target concentration intervention--parameter variability and predictive performance using population pharmacokinetic models for aminoglycosides.
British journal of clinical pharmacology 2004;58(1):8-19.
2004: Phylinda L S Chan; John G Nutt; Nick Holford
Modeling the short- and long-duration responses to exogenous levodopa and to endogenous levodopa production in Parkinson's disease.
Journal of pharmacokinetics and pharmacodynamics 2004;31(3):243-68.
2004: Brian J Anderson; Nick Holford
No urine, no urinary clearance.
European journal of clinical pharmacology 2004;60(4):297.
2003: Caroline D van der Marel; Brian J Anderson; Richard A van Lingen; Nick Holford; M A L Pluim; Frank G A Jansman; John N van den Anker; Dick Tibboel
Paracetamol and metabolite pharmacokinetics in infants.
European journal of clinical pharmacology 2003;59(3):243-51.
2002: Robert A Hauser; Nick Holford
Quantitative description of loss of clinical benefit following withdrawal of levodopa-carbidopa and bromocriptine in early Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2002;17(5):961-8.
2002: Brian Whiting; Nick Holford; Evan J Begg
Clinical pharmacology: principles and practice of drug therapy in medical education.
British journal of clinical pharmacology 2002;54(1):1-2.
2002: Brian J Anderson; Richard A van Lingen; Tom G Hansen; Yuan-Chi Lin; Nick Holford
Acetaminophen developmental pharmacokinetics in premature neonates and infants: a pooled population analysis.
Anesthesiology 2002;96(6):1336-45.
2002: Diane R Mould; Nick Holford; Jan H M Schellens; Jos H Beijnen; Paul R Hutson; Hilde Rosing; Willem W ten Bokkel Huinink; Eric K Rowinsky; Joan H Schiller; Mark Russo; Graham Ross
Population pharmacokinetic and adverse event analysis of topotecan in patients with solid tumors.
Clinical pharmacology and therapeutics 2002;71(5):334-48.
2002: Lewis B Sheiner; Nick Holford
Determination of maximum effect.
Clinical pharmacology and therapeutics 2002;71(4):304; author reply 304-5.
2001: Brian J Anderson; Gerald Woollard; Nick Holford
Acetaminophen analgesia in children: placebo effect and pain resolution after tonsillectomy.
European journal of clinical pharmacology 2001;57(8):559-69.
2001: Nick Holford
Target concentration intervention: beyond Y2K.
British journal of clinical pharmacology 2001;52 Suppl 1():55S-59S.
2001: Phylinda L S Chan; Nick Holford
Drug treatment effects on disease progression.
Annual review of pharmacology and toxicology 2001;41():625-59.
2000: Hui C Kimko; S S Reele; Nick Holford; Carl C Peck
Prediction of the outcome of a phase 3 clinical trial of an antischizophrenic agent (quetiapine fumarate) by simulation with a population pharmacokinetic and pharmacodynamic model.
Clinical pharmacology and therapeutics 2000;68(5):568-77.
2000: B J Anderson; Gerald Woollard; Nick Holford
A model for size and age changes in the pharmacokinetics of paracetamol in neonates, infants and children.
British journal of clinical pharmacology 2000;50(2):125-34.
2000: Brian J Anderson; C J Ralph; A W Stewart; C Barber; Nick Holford
The dose-effect relationship for morphine and vomiting after day-stay tonsillectomy in children.
Anaesthesia and intensive care 2000;28(2):155-60.
2000: Brian J Anderson; S Pearce; J E McGann; A J Newson; Nick Holford
Investigations using logistic regression models on the effect of the LMA on morphine induced vomiting after tonsillectomy.
Paediatric anaesthesia 2000;10(6):633-8.
2000: Nick Holford; Hui C Kimko; JP Monteleone; C C Peck
Simulation of clinical trials.
Annual review of pharmacology and toxicology 2000;40():209-34.
1999: M Schuitmaker; Brian J Anderson; Nick Holford; Gerald Woollard
Pharmacokinetics of paracetamol in adults after cardiac surgery.
Anaesthesia and intensive care 1999;27(6):615-22.
1999: Nick Holford
Target concentration intervention: beyond Y2K.
British journal of clinical pharmacology 1999;48(1):9-13.
1999: Brian J Anderson; T R Gunn; Nick Holford; R Johnson
Caffeine overdose in a premature infant: clinical course and pharmacokinetics.
Anaesthesia and intensive care 1999;27(3):307-11.
1999: Brian J Anderson; Nick Holford; Gerald Woollard; S Kanagasundaram; M Mahadevan
Perioperative pharmacodynamics of acetaminophen analgesia in children.
Anesthesiology 1999;90(2):411-21.
1998: B J Anderson; Nick Holford; Gerald Woollard; Phylinda L S Chan
Paracetamol plasma and cerebrospinal fluid pharmacokinetics in children.
British journal of clinical pharmacology 1998;46(3):237-43.
1997: Brian J Anderson; A D McKee; Nick Holford
Size, myths and the clinical pharmacokinetics of analgesia in paediatric patients.
Clinical pharmacokinetics 1997;33(5):313-27.
1997: Brian J Anderson; Nick Holford; Gerald Woollard
Aspects of theophylline clearance in children.
Anaesthesia and intensive care 1997;25(5):497-501.
1997: B J Anderson; Nick Holford
Rectal paracetamol dosing regimens: determination by computer simulation.
Paediatric anaesthesia 1997;7(6):451-5.