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Jérôme Pugin

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Irène Dunn-Siegrist; Stéphane Moutel; Jacques Bauer; Geneviève Drifte; Pierre Tissières; Jérôme Pugin
Toll-like receptor activation of human cells by synthetic triacylated lipid A-like molecules.
Sophie de Seigneux; Pierre-Yves Martin; Belen Ponte; Jérôme Pugin; Jacques-André Romand; Lucien Weiss; Patrick Saudan
Epoetin administrated after cardiac surgery: effects on renal function and inflammation in a randomized controlled study.
Jérôme Pugin
How tissue injury alarms the immune system and causes a systemic inflammatory response syndrome.

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2012: Irène Dunn-Siegrist; Stéphane Moutel; Jacques Bauer; Geneviève Drifte; Pierre Tissières; Jérôme Pugin
Toll-like receptor activation of human cells by synthetic triacylated lipid A-like molecules.
The Journal of biological chemistry 2012;287(20):16121-31.
2012: Sophie de Seigneux; Pierre-Yves Martin; Belen Ponte; Jérôme Pugin; Jacques-André Romand; Lucien Weiss; Patrick Saudan
Epoetin administrated after cardiac surgery: effects on renal function and inflammation in a randomized controlled study.
BMC nephrology 2012;13():132.
2012: Jérôme Pugin
How tissue injury alarms the immune system and causes a systemic inflammatory response syndrome.
Annals of intensive care 2012;2(1):27.
2012: Pierre Tissières; Michel Berner; Geneviève Drifte; Irène Dunn-Siegrist; Michel Morales; Agnieszka Ochoda; Riccardo Pfister; Jérôme Pugin
Innate immune deficiency of extremely premature neonates can be reversed by interferon-γ.
PloS one 2012;7(3):e32863.
2011: Pierre Emmanuel Charles; Pascal Chavanet; Delphine Croisier; Julien Dufour; Irène Dunn-Siegrist; Saber Davide Barbar; Pierre Tissières; Jérôme Pugin
Mild-stretch mechanical ventilation upregulates toll-like receptor 2 and sensitizes the lung to bacterial lipopeptide.
Critical care (London, England) 2011;15(4):R181.
2009: Pierre Tissières; Tanguy Araud; Agnieszka Ochoda; Geneviève Drifte; Irène Dunn-Siegrist; Jérôme Pugin
Cooperation between PU.1 and CAAT/enhancer-binding protein beta is necessary to induce the expression of the MD-2 gene.
The Journal of biological chemistry 2009;284(39):26261-72.
2009: Pierre Tissières; Jérôme Pugin
The role of MD-2 in the opsonophagocytosis of Gram-negative bacteria.
Current opinion in infectious diseases 2009;22(3):286-91.
2009: Massimo Antonelli; Elie Azoulay; Marc J M Bonten; Jean Chastre; Giuseppe Citerio; Giorgio Conti; Daniel de Backer; François Lemaire; Herwig Gerlach; Johan Groeneveld; Goran Hedenstierna; Duncan Macrae; Jordi Mancebo; Salvatore Maurizio Maggiore; Alexandre Mebazaa; Philipp Metnitz; Jérôme Pugin; Jan Wernerman; Haibo Zhang
Year in review in Intensive Care Medicine, 2008: III. Paediatrics, ethics, outcome research and critical care organization, sedation, pharmacology and miscellanea.
Intensive care medicine 2009;35(3):405-16.
2009: Massimo Antonelli; Elie Azoulay; Marc J M Bonten; Jean Chastre; Giuseppe Citerio; Giorgio Conti; Daniel de Backer; François Lemaire; Herwig Gerlach; Johan Groeneveld; Goran Hedenstierna; Duncan Macrae; Jordi Mancebo; Salvatore Maurizio Maggiore; Alexandre Mebazaa; Philipp Metnitz; Jérôme Pugin; Jan Wernerman; Haibo Zhang
Year in review in Intensive Care Medicine, 2008: II. Experimental, acute respiratory failure and ARDS, mechanical ventilation and endotracheal intubation.
Intensive care medicine 2009;35(2):215-31.
2009: Massimo Antonelli; Elie Azoulay; Marc J M Bonten; Jean Chastre; Giuseppe Citerio; Giorgio Conti; Daniel de Backer; François Lemaire; Herwig Gerlach; Johan Groeneveld; Goran Hedenstierna; Duncan Macrae; Jordi Mancebo; Salvatore Maurizio Maggiore; Alexandre Mebazaa; Philipp Metnitz; Jérôme Pugin; Jan Wernerman; Haibo Zhang
Year in review in Intensive Care Medicine, 2008: I. Brain injury and neurology, renal failure and endocrinology, metabolism and nutrition, sepsis, infections and pneumonia.
Intensive care medicine 2009;35(1):30-44.
2008: Fabienne Brégeon; Laurent Papazian; Stéphane Delpierre; Osamu Kajikawa; Marie-José Payan; Thomas R Martin; Nathalie Kipson; Jérôme Pugin
Role of proinflammatory activity contained in gastric juice from intensive care unit patients to induce lung injury in a rabbit aspiration model.
Critical care medicine 2008;36(12):3205-12.
2008: Jérôme Pugin
Profiling genes in the ICU: are we there yet?
Intensive care medicine 2008;34(8):1357-9.
2008: Massimo Antonelli; Elie Azoulay; Marc J M Bonten; Jean Chastre; Giuseppe Citerio; Giorgio Conti; Daniel de Backer; François Lemaire; Herwig Gerlach; Johan Groeneveld; Goran Hedenstierna; Duncan Macrae; Jordi Mancebo; Salvatore Maurizio Maggiore; Alexandre Mebazaa; Philipp Metnitz; Jérôme Pugin; Jan Wernerman; Haibo Zhang
Year in review in Intensive Care Medicine, 2007. III. Ethics and legislation, health services research, pharmacology and toxicology, nutrition and paediatrics.
Intensive care medicine 2008;34(4):598-609.
2008: Massimo Antonelli; Elie Azoulay; Marc J M Bonten; Jean Chastre; Giuseppe Citerio; Giorgio Conti; Daniel de Backer; François Lemaire; Herwig Gerlach; Johan Groeneveld; Goran Hedenstierna; Duncan Macrae; Jordi Mancebo; Salvatore Maurizio Maggiore; Alexandre Mebazaa; Philipp Metnitz; Jérôme Pugin; Jan Wernerman; Haibo Zhang
Year in review in Intensive Care Medicine, 2007. II. Haemodynamics, pneumonia, infections and sepsis, invasive and non-invasive mechanical ventilation, acute respiratory distress syndrome.
Intensive care medicine 2008;34(3):405-22.
2008: Vandack Nobre; Stephan Harbarth; Jean-Daniel Graf; Peter Rohner; Jérôme Pugin
Use of procalcitonin to shorten antibiotic treatment duration in septic patients: a randomized trial.
American journal of respiratory and critical care medicine 2008;177(5):498-505.
2008: Jérôme Pugin; Irène Dunn-Siegrist; Julien Dufour; Pierre Tissières; Pierre-Emmanuel Charles; Rachel Comte
Cyclic stretch of human lung cells induces an acidification and promotes bacterial growth.
American journal of respiratory cell and molecular biology 2008;38(3):362-70.
2008: Pierre Tissières; Irène Dunn-Siegrist; Michela Schäppi; Greg Elson; Rachel Comte; Vandack Nobre; Jérôme Pugin
Soluble MD-2 is an acute-phase protein and an opsonin for Gram-negative bacteria.
Blood 2008;111(4):2122-31.
2008: Massimo Antonelli; Elie Azoulay; Marc J M Bonten; Jean Chastre; Giuseppe Citerio; Giorgio Conti; Daniel de Backer; François Lemaire; Herwig Gerlach; Johan Groeneveld; Goran Hedenstierna; Duncan Macrae; Jordi Mancebo; Salvatore Maurizio Maggiore; Alexandre Mebazaa; Philipp Metnitz; Jérôme Pugin; Jan Wernerman; Haibo Zhang
Year in review in Intensive Care Medicine, 2007. I. Experimental studies. Clinical studies: brain injury and neurology, renal failure and endocrinology.
Intensive care medicine 2008;34(2):229-42.
2008: Jérôme Pugin
Dear SIRS, the concept of "alarmins" makes a lot of sense!
Intensive care medicine 2008;34(2):218-21.
2007: Irene Dunn-Siegrist; Olivier Leger; Bruno Daubeuf; Yves Poitevin; Fabien Dépis; Suzanne Herren; Marie H Kosco-Vilbois; Yann Dean; Jérôme Pugin; Greg Elson
Pivotal involvement of Fcgamma receptor IIA in the neutralization of lipopolysaccharide signaling via a potent novel anti-TLR4 monoclonal antibody 15C1.
The Journal of biological chemistry 2007;282(48):34817-27.
2007: Vandack Nobre; François P Sarasin; Jérôme Pugin
Prompt antibiotic administration and goal-directed hemodynamic support in patients with severe sepsis and septic shock.
Current opinion in critical care 2007;13(5):586-91.
2007: Peter Andrews; Elie Azoulay; Massimo Antonelli; Laurent Brochard; Christian Brun-Buisson; Daniel de Backer; Geoffrey Dobb; Jean-Yves Fagon; Herwig Gerlach; Johan Groeneveld; Duncan Macrae; Jordi Mancebo; Philipp Metnitz; Stefano Nava; Jérôme Pugin; Michael Pinsky; Peter Radermacher; Christian Richard
Year in Review in Intensive Care Medicine, 2006. III. Circulation, ethics, cancer, outcome, education, nutrition, and pediatric and neonatal critical care.
Intensive care medicine 2007;33(3):414-22.
2007: Greg Elson; Irène Dunn-Siegrist; Bruno Daubeuf; Jérôme Pugin
Contribution of Toll-like receptors to the innate immune response to Gram-negative and Gram-positive bacteria.
Blood 2007;109(4):1574-83.
2007: Peter Andrews; Elie Azoulay; Massimo Antonelli; Laurent Brochard; Christian Brun-Buisson; Daniel de Backer; Geoffrey Dobb; Jean-Yves Fagon; Herwig Gerlach; Johan Groeneveld; Duncan Macrae; Jordi Mancebo; Philipp Metnitz; Stefano Nava; Jérôme Pugin; Michael Pinsky; Peter Radermacher; Christian Richard
Year in review in Intensive Care Medicine, 2006. II. Infections and sepsis, haemodynamics, elderly, invasive and noninvasive mechanical ventilation, weaning, ARDS.
Intensive care medicine 2007;33(2):214-29.
2007: Alain Fraisse; Fabienne Bregeon; Stéphane Delpierre; jean gaudart; Marie José Payan; Jérôme Pugin; Laurent Papazian
Hemodynamics in experimental gastric juice induced aspiration pneumonitis.
Intensive care medicine 2007;33(2):300-7.
2007: Jérôme Pugin
Immunostimulation is a rational therapeutic strategy in sepsis.
Novartis Foundation symposium 2007;280():21-7; discussion 27-36, 160-4.
2007: Peter Andrews; Elie Azoulay; Massimo Antonelli; Laurent Brochard; Christian Brun-Buisson; Daniel de Backer; Geoffrey Dobb; Jean-Yves Fagon; Herwig Gerlach; Johan Groeneveld; Duncan Macrae; Jordi Mancebo; Philipp Metnitz; Stefano Nava; Jérôme Pugin; Michael Pinsky; Peter Radermacher; Christian Richard
Year in review in Intensive Care Medicine, 2006. I. Experimental studies. Clinical studies: brain injury, renal failure and endocrinology.
Intensive care medicine 2007;33(1):49-57.
2006: Patrick Saudan; Michel Niederberger; S De Seigneux; Jacques-André Romand; Jérôme Pugin; Thomas Perneger; Pierre-Yves Martin
Adding a dialysis dose to continuous hemofiltration increases survival in patients with acute renal failure.
Kidney international 2006;70(7):1312-7.
2006: Thierry Fumeaux; Jérôme Pugin
Is the measurement of monocytes HLA-DR expression useful in patients with sepsis?
Intensive care medicine 2006;32(8):1106-8.
2006: Peter Andrews; Elie Azoulay; Massimo Antonelli; Laurent Brochard; Christian Brun-Buisson; Geoffrey Dobb; Jean-Yves Fagon; Herwig Gerlach; Johan Groeneveld; Jordi Mancebo; Philipp Metnitz; Stefano Nava; Jérôme Pugin; Michael Pinsky; Peter Radermacher; Christian Richard; Robert Tasker
Year in review in intensive care medicine, 2005. III. Nutrition, pediatric and neonatal critical care, and experimental.
Intensive care medicine 2006;32(4):490-500.
2006: Peter Andrews; Elie Azoulay; Massimo Antonelli; Laurent Brochard; Christian Brun-Buisson; Geoffrey Dobb; Jean-Yves Fagon; Herwig Gerlach; Johan Groeneveld; Jordi Mancebo; Philipp Metnitz; Stefano Nava; Jérôme Pugin; Michael Pinsky; Peter Radermacher; Christian Richard; Robert Tasker
Year in review in intensive care medicine, 2005. II. Infection and sepsis, ventilator-associated pneumonia, ethics, haematology and haemostasis, ICU organisation and scoring, brain injury.
Intensive care medicine 2006;32(3):380-90.
2006: Stephan Harbarth; Cristina Masuet-Aumatell; Jacques Schrenzel; Patrice Francois; Christophe Akakpo; Gesuele Renzi; Jérôme Pugin; Bara Ricou; Didier Pittet
Evaluation of rapid screening and pre-emptive contact isolation for detecting and controlling methicillin-resistant Staphylococcus aureus in critical care: an interventional cohort study.
Critical care (London, England) 2006;10(1):R25.
2006: Peter Andrews; Elie Azoulay; Massimo Antonelli; Laurent Brochard; Christian Brun-Buisson; Daniel de Backer; Geoffrey Dobb; Jean-Yves Fagon; Herwig Gerlach; Johan Groeneveld; Jordi Mancebo; Philipp Metnitz; Stefano Nava; Jérôme Pugin; Michael Pinsky; Peter Radermacher; Christian Richard; Robert Tasker
Year in review in intensive care medicine. 2005. I. Acute respiratory failure and acute lung injury, ventilation, hemodynamics, education, renal failure.
Intensive care medicine 2006;32(2):207-16.
2006: Arnaud Scherpereel; Florence Depontieu; Bogdan GRIGORIU; Béatrice Cavestri; Anne Tsicopoulos; Thibaut Gentina; Mercé Jourdain; Jérôme Pugin; André-Bernard Tonnel; Philippe Lassalle
Endocan, a new endothelial marker in human sepsis.
Critical care medicine 2006;34(2):532-7.
2005: Stephan Harbarth; Jorge Garbino; Jérôme Pugin; Jacques-André Romand; Didier Pittet
Lack of effect of combination antibiotic therapy on mortality in patients with pneumococcal sepsis.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2005;24(10):688-90.
2005: Pierre Emmanuel Charles; Manuel Etienne; Delphine Croisier; Lionel Piroth; Catherine Lequeu; Jérôme Pugin; Henri Portier; Pascal Chavanet
The impact of mechanical ventilation on the moxifloxacin treatment of experimental pneumonia caused by Streptococcus pneumoniae.
Critical care medicine 2005;33(5):1029-35.
2005: Alain Gervaix; Jérôme Pugin
[Usefulness of procalcitonin in adults and children].
Revue médicale suisse 2005;1(13):872-4, 877.
2005: Peter Andrews; Elie Azoulay; Massimo Antonelli; Laurent Brochard; Christian Brun-Buisson; Geoffrey Dobb; Jean-Yves Fagon; Herwig Gerlach; Johan Groeneveld; Jordi Mancebo; Philipp Metnitz; Stefano Nava; Jérôme Pugin; Michael Pinsky; Peter Radermacher; Christian Richard; Robert Tasker; Benoit Vallet
Year in review in intensive care medicine, 2004. III. Outcome, ICU organisation, scoring, quality of life, ethics, psychological problems and communication in the ICU, immunity and hemodynamics during sepsis, pediatric and neonatal critical care, experimental studies.
Intensive care medicine 2005;31(3):356-72.
2005: Fabienne Brégeon; Stéphane Delpierre; Bruno Chetaille; Osamu Kajikawa; Thomas R Martin; Amapola Autillo-Touati; Yves Jammes; Jérôme Pugin
Mechanical ventilation affects lung function and cytokine production in an experimental model of endotoxemia.
Anesthesiology 2005;102(2):331-9.
2005: Peter Andrews; Elie Azoulay; Massimo Antonelli; Laurent Brochard; Christian Brun-Buisson; Geoffrey Dobb; Jean-Yves Fagon; Herwig Gerlach; Johan Groeneveld; Jordi Mancebo; Philipp Metnitz; Stefano Nava; Jérôme Pugin; Michael Pinsky; Peter Radermacher; Christian Richard; Robert Tasker; Benoit Vallet
Year in review in intensive care medicine, 2004. II. Brain injury, hemodynamic monitoring and treatment, pulmonary embolism, gastrointestinal tract, and renal failure.
Intensive care medicine 2005;31(2):177-88.
2005: Peter Andrews; Elie Azoulay; Massimo Antonelli; Laurent Brochard; Christian Brun-Buisson; Geoffrey Dobb; Jean-Yves Fagon; Herwig Gerlach; Johan Groeneveld; Jordi Mancebo; Philipp Metnitz; Stefano Nava; Jérôme Pugin; Michael Pinsky; Peter Radermacher; Christian Richard; Robert Tasker; Benoit Vallet
Year in review in intensive care medicine, 2004. I. Respiratory failure, infection, and sepsis.
Intensive care medicine 2005;31(1):28-40.
2004: Jérôme Pugin; Sabine Stern-Voeffray; Bruno Daubeuf; Michael A Matthay; Greg Elson; Irène Dunn-Siegrist
Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock.
Blood 2004;104(13):4071-9.
2004: Pierre Emmanuel Charles; Laurent Martin; Manuel Etienne; Delphine Croisier; Lionel Piroth; Catherine Lequeu; Jérôme Pugin; Henri Portier; Pascal Chavanet
Influence of positive end-expiratory pressure (PEEP) on histopathological and bacteriological aspects of pneumonia during low tidal volume mechanical ventilation.
Intensive care medicine 2004;30(12):2263-70.
2004: Karim Bendjelid; Jérôme Pugin
Is Dressler syndrome dead?
Chest 2004;126(5):1680-2.
2004: Thierry Fumeaux; Julien Dufour; Sabine Stern; Jérôme Pugin
Immune monitoring of patients with septic shock by measurement of intraleukocyte cytokines.
Intensive care medicine 2004;30(11):2028-37.
2004: Catherine M Pastor; Jérôme Pugin; Brenda R Kwak; Marc Chanson; François Mach; Antoine Hadengue; Jean-Louis Frossard
Role of Toll-like receptor 4 on pancreatic and pulmonary injury in a mice model of acute pancreatitis associated with endotoxemia.
Critical care medicine 2004;32(8):1759-63.
2004: Stephan Harbarth; Jorge Garbino; Didier Pittet; Jérôme Pugin
Is anti-tumor necrosis factor therapy associated with increased mortality in patients with severe sepsis caused by pneumonia?
The Journal of infectious diseases 2004;189(9):1743.
2004: Alexandra Schmid; Jérôme Pugin; Jean-Claude Chevrolet; S Marsch; S Ludwig; Reto A Stocker; H Finnern
Burden of illness imposed by severe sepsis in Switzerland.
Swiss medical weekly 2004;134(7-8):97-102.
2004: Mitchell A Olman; Kimberly E White; Lorraine B Ware; Warren L Simmons; Etty N Benveniste; Sha Zhu; Jérôme Pugin; Michael A Matthay
Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through IL-1 beta-induced IL-6 expression.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(4):2668-77.
2003: Richard B Goodman; Jérôme Pugin; Janet S Lee; Michael A Matthay
Cytokine-mediated inflammation in acute lung injury.
Cytokine & growth factor reviews 2003;14(6):523-35.
2003: Stephan Harbarth; Jorge Garbino; Jérôme Pugin; Jacques-André Romand; Daniel Lew; Didier Pittet
Inappropriate initial antimicrobial therapy and its effect on survival in a clinical trial of immunomodulating therapy for severe sepsis.
The American journal of medicine 2003;115(7):529-35.
2003: Laurent Spahr; Christoph Becker; Jérôme Pugin; Pietro Majno; Antoine Hadengue
Acute portal hemodynamics and cytokine changesfollowing selective transarterial chemoembolization in patients with cirrhosis and hepatocellular carcinoma.
Medical science monitor : international medical journal of experimental and clinical research 2003;9(9):CR383-8.
2003: Thierry Dugernier; Pierre-François Laterre; Xavier Wittebole; Jean Roeseler; Dominique Latinne; Marc Reynaert; Jérôme Pugin
Compartmentalization of the inflammatory response during acute pancreatitis: correlation with local and systemic complications.
American journal of respiratory and critical care medicine 2003;168(2):148-57.
2003: Jérôme Pugin
Molecular mechanisms of lung cell activation induced by cyclic stretch.
Critical care medicine 2003;31(4 Suppl):S200-6.
2002: Thierry Fumeaux; Jérôme Pugin
Role of interleukin-10 in the intracellular sequestration of human leukocyte antigen-DR in monocytes during septic shock.
American journal of respiratory and critical care medicine 2002;166(11):1475-82.
2002: Laurent Spahr; Laura Rubbia-Brandt; Jean-Louis Frossard; Emiliano Giostra; Anne-Laure Rougemont; Jérôme Pugin; Maria Fischer; Hanspeter Egger; Antoine Hadengue
Combination of steroids with infliximab or placebo in severe alcoholic hepatitis: a randomized controlled pilot study.
Journal of hepatology 2002;37(4):448-55.
2002: Jérôme Pugin
Biomarkers of sepsis: is procalcitonin ready for prime time?
Intensive care medicine 2002;28(9):1203-4.
2002: Fabienne Brégeon; Antoine Roch; Stéphane Delpierre; Eric Ghigo; Amapola Autillo-Touati; Osamu Kajikawa; Thomas R Martin; Jérôme Pugin; Henri Portugal; Jean-Pierre Auffray; Yves Jammes
Conventional mechanical ventilation of healthy lungs induced pro-inflammatory cytokine gene transcription.
Respiratory physiology & neurobiology 2002;132(2):191-203.
2002: Jérôme Pugin
Is the ventilator responsible for lung and systemic inflammation?
Intensive care medicine 2002;28(7):817-9.
2002: Séverine Oudin; Jérôme Pugin
Role of MAP kinase activation in interleukin-8 production by human BEAS-2B bronchial epithelial cells submitted to cyclic stretch.
American journal of respiratory cell and molecular biology 2002;27(1):107-14.
2002: Rudolf Luca; H Roger Lijnen; Anthony F Suffredini; Michael S Pepper; Kenneth P Steinberg; Thomas R Martin; Jérôme Pugin
Increased angiostatin levels in bronchoalveolar lavage fluids from ARDS patients and from human volunteers after lung instillation of endotoxin.
Thrombosis and haemostasis 2002;87(6):966-71.
2002: Jérôme Pugin
Clinical signs and scores for the diagnosis of ventilator-associated pneumonia.
Minerva anestesiologica 2002;68(4):261-5.
2001: William Y Park; Richard B Goodman; Kenneth P Steinberg; John Ruzinski; Frank Radella; David R Park; Jérôme Pugin; Shawn J Skerrett; Leonard D Hudson; Thomas R Martin
Cytokine balance in the lungs of patients with acute respiratory distress syndrome.
American journal of respiratory and critical care medicine 2001;164(10 Pt 1):1896-903.
2001: Laurent Spahr; Laura Rubbia-Brandt; Jérôme Pugin; Emiliano Giostra; Jean-Louis Frossard; B Borisch; Antoine Hadengue
Rapid changes in alcoholic hepatitis histology under steroids: correlation with soluble intercellular adhesion molecule-1 in hepatic venous blood.
Journal of hepatology 2001;35(5):582-9.
2001: Stephan Harbarth; K Holeckova; C Froidevaux; Didier Pittet; Bara Ricou; Georges E Grau; L Vadas; Jérôme Pugin
Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis.
American journal of respiratory and critical care medicine 2001;164(3):396-402.
2001: Naomi P O'Grady; HL Preas; Jérôme Pugin; Carmen Fiuza; Margaret Tropea; Debra Reda; Steven M Banks; Anthony F Suffredini
Local inflammatory responses following bronchial endotoxin instillation in humans.
American journal of respiratory and critical care medicine 2001;163(7):1591-8.
2001: Thomas Geiser; Kamran Atabai; P H Jarreau; Lorraine B Ware; Jérôme Pugin; Michael A Matthay
Pulmonary edema fluid from patients with acute lung injury augments in vitro alveolar epithelial repair by an IL-1beta-dependent mechanism.
American journal of respiratory and critical care medicine 2001;163(6):1384-8.
2001: Laurent Spahr; Isabelle Morard; Antoine Hadengue; L Vadas; Jérôme Pugin
Procalcitonin is not an accurate marker of spontaneous bacterial peritonitis in patients with cirrhosis.
Hepato-gastroenterology 2001;48(38):502-5.
2001: Robert S Munford; Jérôme Pugin
Normal responses to injury prevent systemic inflammation and can be immunosuppressive.
American journal of respiratory and critical care medicine 2001;163(2):316-21.
2001: Robert S Munford; Jérôme Pugin
The crucial role of systemic responses in the innate (non-adaptive) host defense.
Journal of endotoxin research 2001;7(4):327-32.
2000: Bernd Jilma; Nicole Hergovich; Monika Homoncik; Petra Jilma-Stohlawetz; C Kreuzer; Hans-Georg Eichler; Maria Zellner; Jérôme Pugin
Granulocyte colony-stimulating factor (G-CSF) downregulates its receptor (CD114) on neutrophils and induces gelatinase B release in humans.
British journal of haematology 2000;111(1):314-20.
2000: P Farmer; Jérôme Pugin
beta-adrenergic agonists exert their "anti-inflammatory" effects in monocytic cells through the IkappaB/NF-kappaB pathway.
American journal of physiology. Lung cellular and molecular physiology 2000;279(4):L675-82.
2000: Isabelle Tillie-Leblond; Hamida Hammad; S Desurmont; Jérôme Pugin; B Wallaert; A B Tonnel; P Gosset
CC chemokines and interleukin-5 in bronchial lavage fluid from patients with status asthmaticus. Potential implication in eosinophil recruitment.
American journal of respiratory and critical care medicine 2000;162(2 Pt 1):586-92.
2000: Thierry Calandra; Bernd Echtenacher; D L Roy; Jérôme Pugin; C N Metz; Lothar Hültner; Didier Heumann; Daniela N Männel; R Bucala; Michel-Pierre Glauser
Protection from septic shock by neutralization of macrophage migration inhibitory factor.
Nature medicine 2000;6(2):164-70.
1999: F Gisou van der Goot; Jérôme Pugin; Marusa Hribar; L Fransen; Yves Dunant; Patrick De Baetselier; Alain Bloc; Rudolf Lucas
Membrane interaction of TNF is not sufficient to trigger increase in membrane conductance in mammalian cells.
FEBS letters 1999;460(1):107-11.
1999: Marusa Hribar; Alain Bloc; F Gisou van der Goot; L Fransen; Patrick De Baetselier; Georges E Grau; H Bluethmann; M A Matthay; Yves Dunant; Jérôme Pugin; Rudolf Lucas
The lectin-like domain of tumor necrosis factor-alpha increases membrane conductance in microvascular endothelial cells and peritoneal macrophages.
European journal of immunology 1999;29(10):3105-11.
1999: Jérôme Pugin
Sepsis and the immune response.
Intensive care medicine 1999;25(9):1027-8.
1999: Laurent Spahr; Philippe De Saussure; Christian Felley; Jérôme Pugin; Antoine Hadengue
Pseudomembranous colitis: an unusual cause of neutrocytic ascites.
European journal of gastroenterology & hepatology 1999;11(7):789-92.
1999: I Dunn; Jérôme Pugin
Mechanical ventilation of various human lung cells in vitro: identification of the macrophage as the main producer of inflammatory mediators.
Chest 1999;116(1 Suppl):95S-97S.
1999: Jérôme Pugin; M C Widmer; S Kossodo; C M Liang; Anthony F Suffredini
Human neutrophils secrete gelatinase B in vitro and in vivo in response to endotoxin and proinflammatory mediators.
American journal of respiratory cell and molecular biology 1999;20(3):458-64.
1999: Jérôme Pugin; G Verghese; M C Widmer; M A Matthay
The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome.
Critical care medicine 1999;27(2):304-12.
1999: Isabelle Tillie-Leblond; Jérôme Pugin; Charles-Hugo Marquette; Catherine Lamblin; F Saulnier; Anne Brichet; Benoît Wallaert; André-Bernard Tonnel; Philippe Gosset
Balance between proinflammatory cytokines and their inhibitors in bronchial lavage from patients with status asthmaticus.
American journal of respiratory and critical care medicine 1999;159(2):487-94.
1998: Jérôme Pugin; I Dunn; P Jolliet; Didier Tassaux; J L Magnenat; Laurent Nicod; Jean-Claude Chevrolet
Activation of human macrophages by mechanical ventilation in vitro.
The American journal of physiology 1998;275(6 Pt 1):L1040-50.
1998: C Poussin; M Foti; J L Carpentier; Jérôme Pugin
CD14-dependent endotoxin internalization via a macropinocytic pathway.
The Journal of biological chemistry 1998;273(32):20285-91.
1998: Timothy J Sellati; DA Bouis; Richard L Kitchens; R P Darveau; Jérôme Pugin; R J Ulevitch; Sophie C Gangloff; Sanna Goyert; Michael V Norgard; Justin D Radolf
Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides activate monocytic cells via a CD14-dependent pathway distinct from that used by lipopolysaccharide.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(11):5455-64.
1998: Jérôme Pugin; Vladimir V Kravchenko; JD Lee; Lawrence E Kline; Richard J Ulevitch; Peter S Tobias
Cell activation mediated by glycosylphosphatidylinositol-anchored or transmembrane forms of CD14.
Infection and immunity 1998;66(3):1174-80.
1997: D E Schiff; Lawrence E Kline; Katrin Soldau; JD Lee; Jérôme Pugin; Peter S Tobias; Richard J Ulevitch
Phagocytosis of gram-negative bacteria by a unique CD14-dependent mechanism.
Journal of leukocyte biology 1997;62(6):786-94.
1996: Jérôme Pugin; B Ricou; K P Steinberg; P M Suter; T R Martin
Proinflammatory activity in bronchoalveolar lavage fluids from patients with ARDS, a prominent role for interleukin-1.
American journal of respiratory and critical care medicine 1996;153(6 Pt 1):1850-6.
1995: Jérôme Pugin; Richard J Ulevitch; Peter S Tobias
Activation of endothelial cells by endotoxin: direct versus indirect pathways and the role of CD14.
Progress in clinical and biological research 1995;392():369-73.
1995: Jérôme Pugin; Richard J Ulevitch; Peter S Tobias
Tumor necrosis factor-alpha and interleukin-1 beta mediate human endothelial cell activation in blood at low endotoxin concentrations.
Journal of inflammation 1995;45(1):49-55.
1994: Jérôme Pugin; I D Heumann; A Tomasz; Vladimir V Kravchenko; Y Akamatsu; M Nishijima; M P Glauser; Peter S Tobias; Richard J Ulevitch
CD14 is a pattern recognition receptor.
Immunity 1994;1(6):509-16.
1994: Simeon E Goldblum; T W Brann; X Ding; Jérôme Pugin; Peter S Tobias
Lipopolysaccharide (LPS)-binding protein and soluble CD14 function as accessory molecules for LPS-induced changes in endothelial barrier function, in vitro.
The Journal of clinical investigation 1994;93(2):692-702.
1994: Jérôme Pugin
Bacteremia, sepsis and shock.
Intensive care medicine 1994;20(2):92-3.
1994: Peter S Tobias; J Gegner; Jiahuai Han; Theo N Kirkland; Vladimir V Kravchenko; D Leturcq; J D Lee; A Moriarty; John C Mathison; Jérôme Pugin
LPS binding protein and CD14 in the LPS dependent activation of cells.
Progress in clinical and biological research 1994;388():31-9.
1994: Daniel O Slosman; Jérôme Pugin
Lack of correlation between tritiated deoxyglucose, thallium-201 and technetium-99m-MIBI cell incorporation under various cell stresses.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1994;35(1):120-6.
1993: Jérôme Pugin; Richard J Ulevitch; Peter S Tobias
A critical role for monocytes and CD14 in endotoxin-induced endothelial cell activation.
The Journal of experimental medicine 1993;178(6):2193-200.
1993: Jérôme Pugin; C C Schürer-Maly; D Leturcq; A Moriarty; Richard J Ulevitch; Peter S Tobias
Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(7):2744-8.
1992: Peter S Tobias; John C Mathison; D Mintz; J D Lee; Vladimir V Kravchenko; K Kato; Jérôme Pugin; Richard J Ulevitch
Participation of lipopolysaccharide-binding protein in lipopolysaccharide-dependent macrophage activation.
American journal of respiratory cell and molecular biology 1992;7(3):239-45.
1992: Jérôme Pugin; R Auckenthaler; O Delaspre; E van Gessel; P M Suter
Rapid diagnosis of gram negative pneumonia by assay of endotoxin in bronchoalveolar lavage fluid.
Thorax 1992;47(7):547-9.
1992: Jérôme Pugin; P Vanhems; Bernard Hirschel; J P Chave; Markus Flepp
Extreme elevations of serum lactic dehydrogenase differentiating pulmonary toxoplasmosis from Pneumocystis pneumonia.
The New England journal of medicine 1992;326(18):1226.
1992: Jérôme Pugin; P M Suter
Diagnostic bronchoalveolar lavage in patients with pneumonia produces sepsis-like systemic effects.
Intensive care medicine 1992;18(1):6-10.
1991: Jérôme Pugin; J C Chevrolet
[ The intestine-liver-lung axis in septic syndrome].
Schweizerische medizinische Wochenschrift 1991;121(42):1538-44.
1991: Jérôme Pugin; R Auckenthaler; D P Lew; P M Suter
Oropharyngeal decontamination decreases incidence of ventilator-associated pneumonia. A randomized, placebo-controlled, double-blind clinical trial.
JAMA : the journal of the American Medical Association 1991;265(20):2704-10.
1991: Jérôme Pugin; R Auckenthaler; N Mili; J P Janssens; P D Lew; P M Suter
Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and nonbronchoscopic "blind" bronchoalveolar lavage fluid.
The American review of respiratory disease 1991;143(5 Pt 1):1121-9.
1990: Jérôme Pugin
[The diagnosis of pneumonia in the ventilated patient].
Schweizerische medizinische Wochenschrift 1990;120(45):1672-7.