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Antonio Lavecchia

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Antonio Lavecchia; Carmen Cerchia; Carmen Di Giovanni; Annapina Russo; Giulia Russo; Ettore Novellino
Discovery of a novel small molecule inhibitor targeting the frataxin/ubiquitin interaction via structure-based virtual screening and bioassays.
Antonio Laghezza; Antonio Lavecchia; D Capelli; C Di Giovanni; S Faliti; Giuseppe Fracchiolla; Vito Iacobazzi; V Infantino; R Montanari; L Piemontese; Giorgio Pochetti; Paolo Tortorella; Fulvio Loiodice
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression.
Antonio Lavecchia; Nicola Massimiliano Martucci; Mariorosario Masullo; Nunzia Montuori; Emmanuele De Vendittis; Carmen Di Giovanni; Ada Pesapane; Pia Ragno; Ettore Novellino
Discovery of new inhibitors of Cdc25B dual specificity phosphatases by structure-based virtual screening.

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All Publications

2013: Antonio Lavecchia; Carmen Cerchia; Carmen Di Giovanni; Annapina Russo; Giulia Russo; Ettore Novellino
Discovery of a novel small molecule inhibitor targeting the frataxin/ubiquitin interaction via structure-based virtual screening and bioassays.
Journal of medicinal chemistry 2013;56(7):2861-73.
2013: Antonio Laghezza; Antonio Lavecchia; D Capelli; C Di Giovanni; S Faliti; Giuseppe Fracchiolla; Vito Iacobazzi; V Infantino; R Montanari; L Piemontese; Giorgio Pochetti; Paolo Tortorella; Fulvio Loiodice
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression.
Journal of medicinal chemistry 2013;56(1):60-72.
2012: Antonio Lavecchia; Nicola Massimiliano Martucci; Mariorosario Masullo; Nunzia Montuori; Emmanuele De Vendittis; Carmen Di Giovanni; Ada Pesapane; Pia Ragno; Ettore Novellino
Discovery of new inhibitors of Cdc25B dual specificity phosphatases by structure-based virtual screening.
Journal of medicinal chemistry 2012;55(9):4142-58.
2012: Enrica Calleri; Giuseppe Fracchiolla; Antonio Laghezza; Antonio Lavecchia; Fulvio Loiodice; Gabriella Massolini; R Montanari; L Piemontese; Giorgio Pochetti; Caterina Temporini
Frontal affinity chromatography with MS detection of the ligand binding domain of PPARγ receptor: ligand affinity screening and stereoselective ligand-macromolecule interaction.
Journal of chromatography. A 2012;1232():84-92.
2012: Maria Grazia Perrone; Rosanna Rizzi; Paola Vitale; Angela Altomare; Carmen Di Giovanni; Antonio Lavecchia; Paola Malerba; Ettore Novellino; Antonio Scilimati
Diarylheterocycle core ring features effect in selective COX-1 inhibition.
ChemMedChem 2012;7(4):629-41.
2012: Giuseppe Fracchiolla; Antonio Laghezza; Antonio Lavecchia; Roberta Montanari; Ettore Novellino; Mariagiovanna Parente; Luca Piemontese; Giorgio Pochetti; Paolo Tortorella; Giuseppe Carbonara; Carmen Di Giovanni; Fulvio Loiodice
Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors α/γ dual agonists.
Bioorganic & medicinal chemistry 2012;20(6):2141-51.
2012: Carmen Di Giovanni; Alessandro Grottesi; Antonio Lavecchia
Conformational switch of a flexible loop in human laminin receptor determines laminin-1 interaction.
European biophysics journal : EBJ 2012;41(3):353-8.
2011: Antonio Lavecchia; C Di Giovanni; Ettore Novellino
STAT-3 inhibitors: state of the art and new horizons for cancer treatment.
Current medicinal chemistry 2011;18(16):2359-75.
2010: Romano Silvestri; Alessia Ligresti; Giuseppe La Regina; Francesco Piscitelli; Valerio Gatti; Antonio Lavecchia; Antonella Brizzi; Serena Pasquini; Marco Allarà; Noemi Fantini; Mauro Antonio Maria Carai; Chiara Bigogno; Marco Giulio Rozio; Roberta Sinisi; Ettore Novellino; Giancarlo Colombo; Vincenzo Di Marzo; Giulio Dondio; Federico Corelli
Synthesis and biological evaluation of new N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands.
European journal of medicinal chemistry 2010;45(12):5878-86.
2010: Giorgio Pochetti; Nico Mitro; Antonio Lavecchia; Federica Gilardi; Neva Besker; Elena Scotti; Massimiliano Aschi; Nazzareno Re; Giuseppe Fracchiolla; Antonio Laghezza; Paolo Tortorella; Roberta Montanari; Ettore Novellino; Fernando Mazza; Maurizio Crestani; Fulvio Loiodice
Structural insight into peroxisome proliferator-activated receptor gamma binding of two ureidofibrate-like enantiomers by molecular dynamics, cofactor interaction analysis, and site-directed mutagenesis.
Journal of medicinal chemistry 2010;53(11):4354-66.
2009: Lisa Dalla Via; SM Magno; Ornella Gia; Anna Maria Marini; Federico Da Settimo; Silvia Salerno; Concettina La Motta; Francesca Simorini; Sabrina Taliani; Antonio Lavecchia; Carmen Di Giovanni; Giuseppe Brancato; Vincenzo Barone; Ettore Novellino
Benzothiopyranoindole-based antiproliferative agents: synthesis, cytotoxicity, nucleic acids interaction, and topoisomerases inhibition properties.
Journal of medicinal chemistry 2009;52(17):5429-41.
2009: Romano Silvestri; Alessia Ligresti; Giuseppe La Regina; Francesco Piscitelli; Valerio Gatti; Antonella Brizzi; Serena Pasquini; Antonio Lavecchia; Marco Allarà; Noemi Fantini; Mauro Antonio Maria Carai; Ettore Novellino; Giancarlo Colombo; Vincenzo Di Marzo; Federico Corelli
Synthesis, cannabinoid receptor affinity, molecular modeling studies and in vivo pharmacological evaluation of new substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides. 2. Effect of the 3-carboxamide substituent on the affinity and selectivity profile.
Bioorganic & medicinal chemistry 2009;17(15):5549-64.
2009: Francesco Piscitelli; Antonio Coluccia; Andrea Brancale; Giuseppe La Regina; Anna Sansone; Cesare Giordano; Jan Balzarini; giovanni maga; Samantha Zanoli; Alberta Samuele; Roberto Cirilli; Francesco La Torre; Antonio Lavecchia; Ettore Novellino; Romano Silvestri
Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
Journal of medicinal chemistry 2009;52(7):1922-34.
2009: Concettina La Motta; Stefania Sartini; Laura Mugnaini; Silvia Salerno; Francesca Simorini; Sabrina Taliani; Anna Maria Marini; Federico Da Settimo; Antonio Lavecchia; Ettore Novellino; luca Antonioli; Matteo Fornai; Corrado Blandizzi; Mario Del Tacca
Exploiting the pyrazolo[3,4-d]pyrimidin-4-one ring system as a useful template to obtain potent adenosine deaminase inhibitors.
Journal of medicinal chemistry 2009;52(6):1681-92.
2009: Antonio Lavecchia; Carmen Di Giovanni; Ettore Novellino
CDC25A and B dual-specificity phosphatase inhibitors: potential agents for cancer therapy.
Current medicinal chemistry 2009;16(15):1831-49.
2008: Roberta Montanari; Fulvio Saccoccia; Elena Scotti; Maurizio Crestani; Cristina Godio; Federica Gilardi; Fulvio Loiodice; Giuseppe Fracchiolla; Antonio Laghezza; Paolo Tortorella; Antonio Lavecchia; Ettore Novellino; Fernando Mazza; Massimiliano Aschi; Giorgio Pochetti
Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design.
Journal of medicinal chemistry 2008;51(24):7768-76.
2008: Adele Bolognese; Gaetano Correale; Michele Manfra; Anna Esposito; Ettore Novellino; Antonio Lavecchia
Antitumor agents 6. Synthesis, structure-activity relationships, and biological evaluation of spiro[imidazolidine-4,3'-thieno[2,3-g]quinoline]-tetraones and spiro[thieno[2,3-g]quinoline-3,5'-[1,2,4]triazinane]-tetraones with potent antiproliferative activity.
Journal of medicinal chemistry 2008;51(24):8148-57.
2008: Antonio Lavecchia; Antonio Coluccia; Carmen Di Giovanni; Ettore Novellino
Cdc25B phosphatase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective.
Anti-cancer agents in medicinal chemistry 2008;8(8):843-56.
2008: Giuseppe La Regina; Romano Silvestri; Valerio Gatti; Antonio Lavecchia; Ettore Novellino; Olivia Befani; Paola Turini; Enzo Agostinelli
Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B.
Bioorganic & medicinal chemistry 2008;16(22):9729-40.
2008: Giuseppe Fracchiolla; Antonio Lavecchia; Antonio Laghezza; Luca Piemontese; Raffaella Trisolini; Giuseppe Carbonara; Paolo Tortorella; Ettore Novellino; Fulvio Loiodice
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARalpha and PPARgamma agonist activity.
Bioorganic & medicinal chemistry 2008;16(21):9498-510.
2008: Roberto Di Santo; Roberta Costi; Alessandra Roux; Gaetano Miele; Giuliana Cuzzucoli Crucitti; Alberto Iacovo; Federica Rosi; Antonio Lavecchia; Luciana Marinelli; Carmen Di Giovanni; Ettore Novellino; Lucia Palmisano; Mauro Andreotti; Roberta Amici; Clementina M Galluzzo; Lucia Nencioni; Anna Teresa Palamara; Yves Pommier; Christophe Marchand
Novel quinolinonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, and biological activities.
Journal of medicinal chemistry 2008;51(15):4744-50.
2008: Loredana Cappellacci; Palmarisa Franchetti; Patrizia Vita; Riccardo Petrelli; Antonio Lavecchia; Hiremagalur N Jayaram; Philipp Saiko; Geraldine Graser; Thomas Szekeres; Mario Grifantini
Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3'-C-methyladenosine derivatives.
Journal of medicinal chemistry 2008;51(14):4260-9.
2008: Romano Silvestri; Maria Grazia Cascio; Giuseppe La Regina; Francesco Piscitelli; Antonio Lavecchia; Antonella Brizzi; Serena Pasquini; Maurizio Botta; Ettore Novellino; Vincenzo Di Marzo; Federico Corelli
Synthesis, cannabinoid receptor affinity, and molecular modeling studies of substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides.
Journal of medicinal chemistry 2008;51(6):1560-76.
2008: Loredana Cappellacci; Palmarisa Franchetti; Patrizia Vita; Riccardo Petrelli; Antonio Lavecchia; Barbara Costa; Francesca Spinetti; Claudia Martini; Karl-Norbert Klotz; Mario Grifantini
5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 receptor from different species.
Bioorganic & medicinal chemistry 2008;16(1):336-53.
2007: Caterina Temporini; Enrica Calleri; Giuseppe Fracchiolla; Giuseppe Carbonara; Fulvio Loiodice; Antonio Lavecchia; Paolo Tortorella; GLORIA BRUSOTTI; Gabriella Massolini
Enantiomeric separation of 2-aryloxyalkyl- and 2-arylalkyl-2-aryloxyacetic acids on a Penicillin G Acylase-based chiral stationary phase: influence of the chemical structure on retention and enantioselectivity.
Journal of pharmaceutical and biomedical analysis 2007;45(2):211-8.
2007: Concettina La Motta; Stefania Sartini; Laura Mugnaini; Francesca Simorini; Sabrina Taliani; Silvia Salerno; Anna Maria Marini; Federico Da Settimo; Antonio Lavecchia; Ettore Novellino; Miriam Cantore; Paola Failli; Mario Ciuffi
Pyrido[1,2-a]pyrimidin-4-one derivatives as a novel class of selective aldose reductase inhibitors exhibiting antioxidant activity.
Journal of medicinal chemistry 2007;50(20):4917-27.
2007: Ana C Montes-Gil; Marcos Zanfolin; Cristina E Okuyama; Sergio Lilla; Delma P Alves; Vincenzo Santagada; Elisa Perissutti; Antonio Lavecchia; Ferdinando Fiorino; Beatrice Severino; Giuseppe Caliendo; Fernanda Priviero; Gustavo D Mendes; Jose Luiz Donato; Gilberto de Nucci
Pharmacokinetic profile of atenolol aspirinate.
Archiv der Pharmazie 2007;340(9):445-55.
2007: Giuseppe La Regina; Michael Edler; Andrea Brancale; Sahar Kandil; Antonio Coluccia; Francesco Piscitelli; Ernest Hamel; Gabriella De Martino; Ruth Matesanz; J Fernando Díaz; Anna Scovassi; Ennio Prosperi; Antonio Lavecchia; Ettore Novellino; Marino Artico; Romano Silvestri
Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies.
Journal of medicinal chemistry 2007;50(12):2865-74.
2007: Giorgio Pochetti; Cristina Godio; Nico Mitro; Donatella Caruso; Andrea Galmozzi; Silvia Scurati; Fulvio Loiodice; Giuseppe Fracchiolla; Paolo Tortorella; Antonio Laghezza; Antonio Lavecchia; Ettore Novellino; Fernando Mazza; Maurizio Crestani
Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands.
The Journal of biological chemistry 2007;282(23):17314-24.
2007: Giuseppe Fracchiolla; Antonio Laghezza; Luca Piemontese; Giuseppe Carbonara; Antonio Lavecchia; Paolo Tortorella; Maurizio Crestani; Ettore Novellino; Fulvio Loiodice
Synthesis, biological evaluation, and molecular modeling investigation of chiral phenoxyacetic acid analogues with PPARalpha and PPARgamma agonist activity.
ChemMedChem 2007;2(5):641-54.
2007: Sandro Cosconati; Luciana Marinelli; Antonio Lavecchia; Ettore Novellino
Characterizing the 1,4-dihydropyridines binding interactions in the L-type Ca2+ channel: model construction and docking calculations.
Journal of medicinal chemistry 2007;50(7):1504-13.
2007: Giuseppe La Regina; Romano Silvestri; Marino Artico; Antonio Lavecchia; Ettore Novellino; Olivia Befani; Paola Turini; Enzo Agostinelli
New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.
Journal of medicinal chemistry 2007;50(5):922-31.
2007: Antonio Lavecchia; Sandro Cosconati; Ettore Novellino; Enrica Calleri; Caterina Temporini; Gabriella Massolini; Giuseppe Carbonara; Giuseppe Fracchiolla; Fulvio Loiodice
Exploring the molecular basis of the enantioselective binding of penicillin G acylase towards a series of 2-aryloxyalkanoic acids: a docking and molecular dynamics study.
Journal of molecular graphics & modelling 2007;25(6):773-83.
2006: Antonio Lavecchia; Roberta Costi; Marino Artico; Gaetano Miele; Ettore Novellino; Alberto Bergamini; Emmanuele Crespan; giovanni maga; Roberto Di Santo
Arylthiopyrrole (AThP) derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis, structure-activity relationships, and docking studies (part 2).
ChemMedChem 2006;1(12):1379-90.
2006: Roberto Di Santo; Roberta Costi; Marino Artico; Gaetano Miele; Antonio Lavecchia; Ettore Novellino; Alberto Bergamini; Reynel Cancio; giovanni maga
Arylthiopyrrole (AThP) derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis, structure-activity relationships, and docking studies (part 1).
ChemMedChem 2006;1(12):1367-78.
2006: Romano Silvestri; Gabriella Marfè; Marino Artico; Giuseppe La Regina; Antonio Lavecchia; Ettore Novellino; Emanuela Morgante; Manuela Morgante; Carla Di Stefano; Gianfranco Catalano; Giuseppe Filomeni; Elisabetta Abruzzese; Maria Rosa Ciriolo; Matteo A Russo; Sergio Amadori; Roberto Cirilli; Francesco La Torre; Paola Sinibaldi-Salimei
Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs): A new class of agents with high apoptotic activity in chronic myelogenous leukemia K562 cells and in cells from patients at onset and who were imatinib-resistant.
Journal of medicinal chemistry 2006;49(19):5840-4.
2006: Adele Bolognese; Gaetano Correale; Michele Manfra; Antonio Lavecchia; Ettore Novellino; Stefano Pepe
Antitumor agents. 5. synthesis, structure-activity relationships, and biological evaluation of dimethyl-5H-pyridophenoxazin-5-ones, tetrahydro-5h-benzopyridophenoxazin-5-ones, and 5h-benzopyridophenoxazin-5-ones with potent antiproliferative activity.
Journal of medicinal chemistry 2006;49(17):5110-8.
2006: Gabriella Massolini; Giuseppe Fracchiolla; Enrica Calleri; Giuseppe Carbonara; Caterina Temporini; Antonio Lavecchia; Sandro Cosconati; Ettore Novellino; Fulvio Loiodice
Elucidation of the enantioselective recognition mechanism of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxy-2-arylacetic acids.
Chirality 2006;18(8):633-43.
2006: Rino Ragno; Antonio Coluccia; Giuseppe La Regina; Gabriella De Martino; Francesco Piscitelli; Antonio Lavecchia; Ettore Novellino; Alberto Bergamini; Chiara Ciaprini; Anna Sinistro; giovanni maga; Emmanuele Crespan; Marino Artico; Romano Silvestri
Design, molecular modeling, synthesis, and anti-HIV-1 activity of new indolyl aryl sulfones. Novel derivatives of the indole-2-carboxamide.
Journal of medicinal chemistry 2006;49(11):3172-84.
2006: Antonio Lavecchia; Sandro Cosconati; Vittorio Limongelli; Ettore Novellino
Modeling of Cdc25B dual specifity protein phosphatase inhibitors: docking of ligands and enzymatic inhibition mechanism.
ChemMedChem 2006;1(5):540-50.
2006: Roberto Di Santo; Roberta Costi; Alessandra Roux; Marino Artico; Antonio Lavecchia; Luciana Marinelli; Ettore Novellino; Lucia Palmisano; Mauro Andreotti; Roberta Amici; Clementina M Galluzzo; Lucia Nencioni; Anna Teresa Palamara; Yves Pommier; Christophe Marchand
Novel bifunctional quinolonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, biological activities, and mechanism of action.
Journal of medicinal chemistry 2006;49(6):1939-45.
2006: Vincenzo Santagada; Giuseppe Caliendo; Beatrice Severino; Antonio Lavecchia; Elisa Perissutti; Ferdinando Fiorino; Angela Zampella; Valentina Sepe; Daniela Califano; Giovanni Santelli; Ettore Novellino
Synthesis, pharmacological evaluation, and molecular modeling studies of novel peptidic CAAX analogues as farnesyl-protein-transferase inhibitors.
Journal of medicinal chemistry 2006;49(6):1882-90.
2006: Roberto Di Santo; Roberta Costi; Marino Artico; Rino Ragno; Antonio Lavecchia; Ettore Novellino; Enrico Gavuzzo; Francesco La Torre; Roberto Cirilli; Reynel Cancio; giovanni maga
Design, synthesis, biological evaluation, and molecular modeling studies of TIBO-like cyclic sulfones as non-nucleoside HIV-1 reverse transcriptase inhibitors.
ChemMedChem 2006;1(1):82-95.
2005: Ettore Novellino; Barbara Cosimelli; Marina Ehlardo; Giovanni Greco; Manuela Iadanza; Antonio Lavecchia; Maria Grazia Rimoli; Annalisa Sala; Antonio Da Settimo; Giampaolo Primofiore; Federico Da Settimo; Sabrina Taliani; Concettina La Motta; Karl-Norbert Klotz; Daniela Tuscano; Maria Letizia Trincavelli; Claudia Martini
2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database searching.
Journal of medicinal chemistry 2005;48(26):8253-60.
2005: Gjermund Henriksen; Stefan Platzer; János Marton; Andrea Hauser; Achim Berthele; Markus Schwaiger; Luciana Marinelli; Antonio Lavecchia; Ettore Novellino; Hans-Jürgen Wester
Syntheses, biological evaluation, and molecular modeling of 18F-labeled 4-anilidopiperidines as mu-opioid receptor imaging agents.
Journal of medicinal chemistry 2005;48(24):7720-32.
2005: Federico Da Settimo; Giampaolo Primofiore; Concettina La Motta; Stefania Sartini; Sabrina Taliani; Francesca Simorini; Anna Maria Marini; Antonio Lavecchia; Ettore Novellino; Enrico Boldrini
Naphtho[1,2-d]isothiazole acetic acid derivatives as a novel class of selective aldose reductase inhibitors.
Journal of medicinal chemistry 2005;48(22):6897-907.
2005: Arnaldo Pinelli; Cristina Godio; Antonio Laghezza; Nico Mitro; Giuseppe Fracchiolla; Vincenzo Tortorella; Antonio Lavecchia; Ettore Novellino; Jean-Charles Fruchart; Bart Staels; Maurizio Crestani; Fulvio Loiodice
Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARalpha and PPARgamma agonist activity.
Journal of medicinal chemistry 2005;48(17):5509-19.
2005: Federico Da Settimo; Giampaolo Primofiore; Concettina La Motta; Sabrina Taliani; Francesca Simorini; Anna Maria Marini; Laura Mugnaini; Antonio Lavecchia; Ettore Novellino; Daniela Tuscano; Claudia Martini
Novel, highly potent adenosine deaminase inhibitors containing the pyrazolo[3,4-d]pyrimidine ring system. Synthesis, structure-activity relationships, and molecular modeling studies.
Journal of medicinal chemistry 2005;48(16):5162-74.
2005: Luciana Marinelli; Axel Meyer; Dominik Heckmann; Antonio Lavecchia; Ettore Novellino; Horst Kessler
Ligand binding analysis for human alpha5beta1 integrin: strategies for designing new alpha5beta1 integrin antagonists.
Journal of medicinal chemistry 2005;48(13):4204-7.
2005: Antonio Lavecchia; Sandro Cosconati; Ettore Novellino
Architecture of the human urotensin II receptor: comparison of the binding domains of peptide and non-peptide urotensin II agonists.
Journal of medicinal chemistry 2005;48(7):2480-92.
2005: Loredana Cappellacci; Palmarisa Franchetti; Michela Pasqualini; Riccardo Petrelli; Patrizia Vita; Antonio Lavecchia; Ettore Novellino; Barbara Costa; Claudia Martini; Karl-Norbert Klotz; Mario Grifantini
Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists.
Journal of medicinal chemistry 2005;48(5):1550-62.
2005: Federico Da Settimo; Giampaolo Primofiore; Concettina La Motta; Silvia Salerno; Ettore Novellino; Giovanni Greco; Antonio Lavecchia; Sonia Laneri; Enrico Boldrini
Spirohydantoin derivatives of thiopyrano[2,3-b]pyridin-4(4H)-one as potent in vitro and in vivo aldose reductase inhibitors.
Bioorganic & medicinal chemistry 2005;13(2):491-9.
2004: Adele Bolognese; Gaetano Correale; Michele Manfra; Antonio Lavecchia; Ettore Novellino; Vincenzo Barone
Thiazolidin-4-one formation. Mechanistic and synthetic aspects of the reaction of imines and mercaptoacetic acid under microwave and conventional heating.
Organic & biomolecular chemistry 2004;2(19):2809-13.
2004: Adele Bolognese; Gaetano Correale; Michele Manfra; Antonio Lavecchia; Orazio Mazzoni; Ettore Novellino; Paolo La Colla; Giuseppina Sanna; Roberta Loddo
Antitumor agents. 3. Design, synthesis, and biological evaluation of new pyridoisoquinolindione and dihydrothienoquinolindione derivatives with potent cytotoxic activity.
Journal of medicinal chemistry 2004;47(4):849-58.
2003: Angelo Alberti; Adele Bolognese; Maurizio Guerra; Antonio Lavecchia; Dante Macciantelli; Massimo Marcaccio; Ettore Novellino; Francesco Paolucci
Antitumor agents 4. Characterization of free radicals produced during reduction of the antitumor drug 5H-pyridophenoxazin-5-one: an EPR study.
Biochemistry 2003;42(41):11924-31.
2003: Luciana Marinelli; Antonio Lavecchia; Kay-Eberhard Gottschalk; Ettore Novellino; Horst Kessler
Docking studies on alphavbeta3 integrin ligands: pharmacophore refinement and implications for drug design.
Journal of medicinal chemistry 2003;46(21):4393-404.
2003: Renate M van Well; Luciana Marinelli; Cornelis Altona; Kees Erkelens; Gregg Siegal; Mark van Raaij; Antonio Luis Llamas-Saiz; Horst Kessler; Ettore Novellino; Antonio Lavecchia; Jacques H van Boom; Mark Overhand
Conformational analysis of furanoid epsilon-sugar amino acid containing cyclic peptides by NMR spectroscopy, molecular dynamics simulation, and X-ray crystallography: evidence for a novel turn structure.
Journal of the American Chemical Society 2003;125(36):10822-9.
2003: Federico Da Settimo; Giampaolo Primofiore; Antonio Da Settimo; Concettina La Motta; Francesca Simorini; Ettore Novellino; Giovanni Greco; Antonio Lavecchia; Enrico Boldrini
Novel, highly potent aldose reductase inhibitors: cyano(2-oxo-2,3-dihydroindol-3-yl)acetic acid derivatives.
Journal of medicinal chemistry 2003;46(8):1419-28.
2003: Gabriella Massolini; Enrica Calleri; Antonio Lavecchia; Fulvio Loiodice; Dieter Lubda; Caterina Temporini; Giuseppe Fracchiolla; Paolo Tortorella; Ettore Novellino; Gabriele Caccialanza
Enantioselective hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues using a penicillin G acylase-based HPLC monolithic silica column.
Analytical chemistry 2003;75(3):535-42.
2002: Paolo Grieco; Antonio Lavecchia; Minying Cai; Dev Trivedi; David Weinberg; Tanya MacNeil; Lex H T Van Der Ploeg; Victor J Hruby
Structure-activity studies of the melanocortin peptides: discovery of potent and selective affinity antagonists for the hMC3 and hMC4 receptors.
Journal of medicinal chemistry 2002;45(24):5287-94.
2002: Adele Bolognese; Gaetano Correale; Michele Manfra; Antonio Lavecchia; Orazio Mazzoni; Ettore Novellino; Vincenzo Barone; Paolo La Colla; Roberta Loddo
Antitumor agents. 2. Synthesis, structure-activity relationships, and biological evaluation of substituted 5H-pyridophenoxazin-5-ones with potent antiproliferative activity.
Journal of medicinal chemistry 2002;45(24):5217-23.
2002: Adele Bolognese; Gaetano Correale; Michele Manfra; Antonio Lavecchia; Orazio Mazzoni; Ettore Novellino; Vincenzo Barone; Alessandra Pani; Enzo Tramontano; Paolo La Colla; Chiara Murgioni; Ilaria Serra; Giovanna Setzu; Roberta Loddo
Antitumor agents. 1. Synthesis, biological evaluation, and molecular modeling of 5H-pyrido[3,2-a]phenoxazin-5-one, a compound with potent antiproliferative activity.
Journal of medicinal chemistry 2002;45(24):5205-16.
2002: Ettore Novellino; Enrico Abignente; Barbara Cosimelli; Giovanni Greco; Manuela Iadanza; Sonia Laneri; Antonio Lavecchia; Maria Grazia Rimoli; Federico Da Settimo; Giampaolo Primofiore; Daniela Tuscano; Letizia Trincavelli; Claudia Martini
Design, synthesis and biological evaluation of novel N-alkyl- and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs) as novel A(1) adenosine receptor antagonists.
Journal of medicinal chemistry 2002;45(23):5030-6.
2001: Federico Da Settimo; Giampaolo Primofiore; Antonio Da Settimo; Concettina La Motta; Sabrina Taliani; Francesca Simorini; Ettore Novellino; Giovanni Greco; Antonio Lavecchia; Enrico Boldrini
[1,2,4]Triazino[4,3-a]benzimidazole acetic acid derivatives: a new class of selective aldose reductase inhibitors.
Journal of medicinal chemistry 2001;44(25):4359-69.
2001: Antonello Mai; Gianluca Sbardella; Marino Artico; Rino Ragno; Silvio Massa; Ettore Novellino; G Greco; Antonio Lavecchia; Chiara Musiu; Massimiliano La Colla; Chiara Murgioni; Paolo La Colla; Roberta Loddo
Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Journal of medicinal chemistry 2001;44(16):2544-54.
2001: Giampaolo Primofiore; F D Settimo; Sabrina Taliani; Anna Maria Marini; Ettore Novellino; Giovanni Greco; Antonio Lavecchia; Francois Besnard; Letizia Trincavelli; Barbara Costa; Claudia Martini
Novel N-(arylalkyl)indol-3-ylglyoxylylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships.
Journal of medicinal chemistry 2001;44(14):2286-97.
2001: Federico Da Settimo; Giampaolo Primofiore; Sabrina Taliani; Anna Maria Marini; Concettina La Motta; Ettore Novellino; Giovanni Greco; Antonio Lavecchia; Letizia Trincavelli; Claudia Martini
3-Aryl[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: a new class of selective A1 adenosine receptor antagonists.
Journal of medicinal chemistry 2001;44(3):316-27.
2000: Romano Silvestri; Marino Artico; Gabriella De Martino; Ettore Novellino; G Greco; Antonio Lavecchia; Silvio Massa; Anna Giulia Loi; S Doratiotto; Paolo La Colla
Computer-assisted design, synthesis and biological evaluation of novel pyrrolyl heteroaryl sulfones targeted at HIV-1 reverse transcriptase as non-nucleoside inhibitors.
Bioorganic & medicinal chemistry 2000;8(9):2305-9.
2000: Antonio Lavecchia; Giovanni Greco; Ettore Novellino; Franco Vittorio; Giuseppe Ronsisvalle
Modeling of kappa-opioid receptor/agonists interactions using pharmacophore-based and docking simulations.
Journal of medicinal chemistry 2000;43(11):2124-34.
2000: P Vianello; A Albinati; Gérard A Pinna; Antonio Lavecchia; Luciana Marinelli; P A Borea; Stefania Gessi; Paola Fadda; S Tronci; Giorgio Cignarella
Synthesis, molecular modeling, and opioid receptor affinity of 9, 10-diazatricyclo[4.2.1.1(2,5)]decanes and 2,7-diazatricyclo[4.4.0. 0(3,8)]decanes structurally related to 3,8-diazabicyclo[3.2. 1]octanes.
Journal of medicinal chemistry 2000;43(11):2115-23.
2000: Roberta Costi; Roberto Di Santo; Marino Artico; Silvio Massa; Antonio Lavecchia; Tiziana Marceddu; L Sanna; Paolo La Colla; Maria Elena Marongiu
Structure-activity relationship studies on potential non-nucleoside DABO-like inhibitors of HIV-1 reverse transcriptase.
Antiviral chemistry & chemotherapy 2000;11(2):117-33.
1999: Anna Maria D'Ursi; Stefania Albrizio; Caterina Fattorusso; Antonio Lavecchia; G Zanotti; Piero A Temussi
Solution conformation of a potent cyclic analogue of tuftsin: low- temperature nuclear magnetic resonance study in a cryoprotective mixture.
Journal of medicinal chemistry 1999;42(10):1705-13.