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John Holloway

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Samuel A Collins; Keith M Godfrey; John W Holloway; Hazel M Inskip; Jane S A Lucas; Graham Roberts
HHIP, HDAC4, NCR3 and RARB polymorphisms affect fetal, childhood and adult lung function.
Wilfried Karmaus; Ali H Ziyab; Todd Everson; John W Holloway
Epigenetic mechanisms and models in the origins of asthma.
Nelís Soto-Ramírez; Hongmei Zhang; Veeresh Patil; Eric Schauberger; Syed Hasan Arshad; Susan L Ewart; John W Holloway; Wilfried Karmaus
The interaction of genetic variants and DNA methylation of the interleukin-4 receptor gene increase the risk of asthma at age 18 years.

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2013: Samuel A Collins; Keith M Godfrey; John W Holloway; Hazel M Inskip; Jane S A Lucas; Graham Roberts
HHIP, HDAC4, NCR3 and RARB polymorphisms affect fetal, childhood and adult lung function.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2013;41(3):756-7.
2013: Wilfried Karmaus; Ali H Ziyab; Todd Everson; John W Holloway
Epigenetic mechanisms and models in the origins of asthma.
Current opinion in allergy and clinical immunology 2013;13(1):63-9.
2013: Nelís Soto-Ramírez; Hongmei Zhang; Veeresh Patil; Eric Schauberger; Syed Hasan Arshad; Susan L Ewart; John W Holloway; Wilfried Karmaus
The interaction of genetic variants and DNA methylation of the interleukin-4 receptor gene increase the risk of asthma at age 18 years.
Clinical epigenetics 2013;5(1):1.
2013: Momoko Horikoshi; Jouke-Jan Hottenga; David M Hougaard; Elina Hyppönen; Hazel M Inskip; Aaron Isaacs; Vincent W V Jaddoe; Karen A Jameson; Marjo-Riitta Jarvelin; Torben Jørgensen; Marika Kaakinen; Christina Kanaka-Gantenbein; John P Kemp; Marjan Kerkhof; Wieland Kiess; Tuomas O Kilpeläinen; Mirna Kirin; Norman Klopp; Bridget A Knight; Gerard H Koppelman; Antje Körner; Eskil Kreiner-Møller; Zoltán Kutalik; Christopher W Kuzawa; Vasiliki Lagou; Timo A Lakka; Debbie A Lawlor; Terho Lehtimäki; Virpi Lindi; Ruth J F Loos; Anubha Mahajan; Mark I McCarthy; George McMahon; Aline Meirhaeghe; Mads Melbye; Brian F Meyer; Karen L Mohlke; Dorota M Monies; Dennis O Mook-Kanamori; Luis A Moreno; John P Newnham; Harri Niinikoski; Ioanna Ntalla; Ken K Ong; Ben A Oostra; Ewan R Pearson; Louise Pedersen; Oluf Pedersen; Craig E Pennell; Thiemo Pfab; Dirkje S Postma; Anneli Pouta; Chris Power; Andrew M Prentice; Inga Prokopenko; Olli T Raitakari; Susan M Ring; Fernando Rivadeneira; Neil R Robertson; Maiju Saarinen; Rany M Salem; Seang-Mei Saw; Sylvain Sebert; Beverley M Shields; Olli Simell; Torsten Slowinski; George Davey Smith; Ulla Sovio; Beate St Pourcain; Michael Stumvoll; H Rob Taal; Elisabeth Thiering; Carla M T Tiesler; Nicholas J Timpson; Anke Tönjes; André G Uitterlinden; Allan Vaag; Cornelia M van Duijn; Elisabeth M van Leeuwen; Jorma S Viikari; Jacqueline M Vink; Nadja Hawwa Vissing; Peter Vollenweider; Nicholas J Wareham; Nicole M Warrington; Elisabeth Widén; Gonneke Willemsen; James F Wilson; Daniel R Witte; Ying Wu; Hanieh Yaghootkar; Haitao Zhang; Jianhua Zhao; Jing Hua Zhao; Kaixin Zhou; Linda S Adair; Fowzan S Alkuraya; Ali Al-Odaib; Philippe Amouyel; Ehm Astrid Andersson; Sheila J Barton; Amanda J Bennett; Diane J Berry; Hans Bisgaard; Alexandra I F Blakemore; Klaus Bønnelykke; Dorret I Boomsma; Colin A G Boreham; Jonathan P Bradfield; Mariona Bustamante; Jessica L Buxton; Pimphen Charoen; Cyrus Cooper; Diana L Cousminer; Jean Dallongeville; Shikta Das; Eco J C de Geus; George V Dedoussis; Marcel den Hoed; Johan G Eriksson; Xavier Estivill; David M Evans; Bjarke Feenstra; Claudia Flexeder; Timothy M Frayling; Rachel M Freathy; Philippe Froguel; Anthony J Fulford; Frank Geller; Matthew W Gillman; Keith M Godfrey; Liang-Kee Goh; Frédéric Gottrand; Struan F A Grant; Christopher J Groves; Mònica Guxens; Hakon Hakonarson; Torben Hansen; Marie N Harder; Andrew T Hattersley; Jani Heikkinen; Joachim Heinrich; Branwen J Hennig; Joel N Hirschhorn; Berthold Hocher; Albert Hofman; Mads V Hollegaard; John W Holloway
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
Nature genetics 2013;45(1):76-82.
2012: Philip C Boger; John W Holloway; James R Neale; Praful Patel; James D Shutt; Susan J Wilson; Adrian C Bateman; Anthony P Sampson
Increased expression of the 5-lipoxygenase pathway and its cellular localization in Barrett's adenocarcinoma.
Histopathology 2012;61(3):509-17.
2012: Y I Wan; B A H Al-Momani; M Bafadhel; S Baltic; J D Blakey; C E Brightling; M A Brown; A Bush; R Chaudhuri; K F Chung; W O C M Cookson; M A R Ferreira; L Heaney; John W Holloway; P H Howarth; J Hui; A L James; S Manney; A H Mansur; M F Moffatt; A W Musk; R Niven; I Sayers; N R G Shrine; A Simpson; A Singapuri; M Soler Artigas; D P Strachan; P J Thompson; N C Thomson; M D Tobin; L V Wain; I P Hall
Genome-wide association study to identify genetic determinants of severe asthma.
Thorax 2012;67(9):762-8.
2012: Chuan Wang; Vincent Bours; Stephen T Holgate; John W Holloway; Gerard H Koppelman; Dirkje S Postma; Matthew J Rose-Zerilli; Johanna K Sandling; Ann-Christine Syvänen; Vinciane Dideberg
Evidence of association between interferon regulatory factor 5 gene polymorphisms and asthma.
Gene 2012;504(2):220-5.
2012: S Hasan Arshad; John W Holloway; Wilfried Karmaus; Ramesh J Kurukulaaratchy; Sharon M Matthews; Abid Raza; Graham Roberts; Alireza Sadeghnejad; Hongmei Zhang; Susan L Ewart
The effect of parental allergy on childhood allergic diseases depends on the sex of the child.
The Journal of allergy and clinical immunology 2012;130(2):427-34.e6.
2012: Robert A Scott; Peter Shrader; Dmitry Shungin; David S Siscovick; Alena Stancáková; Heather M Stringham; Michael Stumvoll; Toshiko Tanaka; Tanya M Teslovich; Anke Tönjes; Peter Vollenweider; Gérard Waeber; Mark Walker; Nicholas J Wareham; Richard M Watanabe; Gordon H Williams; Daniel R Witte; Andrew R Wood; Weijia Xie; Ajay Yesupriya; Cécile Lecoeur; Claire Lévy-Marchal; Guo Li; Ruth J F Loos; Valeri Lyssenko; Alisa K Manning; Diana Marek; Michael Marmot; Pedro Marques-Vidal; James B Meigs; Mario A Morken; Gabriele Müller; Kari E North; James S Pankow; Felicity Payne; Oluf Pedersen; Inga Prokopenko; Bruce M Psaty; Laura J Rasmussen-Torvik; Frida Renström; Ken Rice; Jerome I Rotter; Denis Rybin; Camilla H Sandholt; Avan A Sayer; Peter E H Schwarz; Mette Aadahl; Dan E Arking; Daniel Barnes; Inês Barroso; Sven Bergmann; Michael Boehnke; Eric Boerwinkle; Lori L Bonnycastle; Stefan R Bornstein; Nabila Bouatia-Naji; Soren Brage; Eric Brunner; Suzannah J Bumpstead; Olga D Carlson; Han Chen; Yii-Der Ida Chen; Peter S Chines; Audrey Y Chu; Francis S Collins; Cyrus Cooper; David J Couper; Elaine M Dennison; Nicole F Dowling; Josée Dupuis; Josephine S Egan; Ulf Ekelund; Michael R Erdos; Luigi Ferrucci; Jose C Florez; Nita G Forouhi; Caroline S Fox; Paul W Franks; Philippe Froguel; Nicole L Glazer; Mark O Goodarzi; Niels Grarup; Jürgen Grässler; Leif Groop; Stefan Gustafsson; Göran Hallmans; Torben Hansen; Aroon Hingorani; Marie-France Hivert; John W Holloway; Frank B Hu; Erik Ingelsson; Bo Isomaa; Anne U Jackson; Karen A Jameson; Ingegerd Johansson; Anna Jonsson; Torben Jørgensen; WEN KAO; Mika Kivimaki; Peter Kovacs; Meena Kumari; Zoltan Kutalik; Johanna Kuusisto; Markku Laakso; Vasiliki Lagou; Claudia Langenberg
No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels.
Diabetes 2012;61(5):1291-6.
2012: John W Holloway; Santiyagu Savarimuthu Francis; Kwun M Fong; Ian A Yang
Genomics and the respiratory effects of air pollution exposure.
Respirology (Carlton, Vic.) 2012;17(4):590-600.
2012: Gerard H Koppelman; John W Holloway
Successful grant writing.
Paediatric respiratory reviews 2012;13(1):63-6.
2012: Asif S Tulah; Sheila J Barton; Bianca Beghé; John W Holloway; Ian Sayers
Leukotriene B4 receptor locus gene characterisation and association studies in asthma.
BMC medical genetics 2012;13():110.
2012: Ali H Ziyab; Susan L Ewart; John W Holloway; Wilfried Karmaus; Eric Schauberger; Mitra Yousefi; Hongmei Zhang; Syed Hasan Arshad
Interplay of filaggrin loss-of-function variants, allergic sensitization, and eczema in a longitudinal study covering infancy to 18 years of age.
PloS one 2012;7(3):e32721.
2012: Sarah E Jackson; John W Holloway; Jane A Warner; Anthony P Sampson
Interleukin-13, but not indomethacin, increases cysteinyl-leukotriene synthesis in human lung macrophages.
Journal of allergy 2012;2012():348741.
2012: D S Postma; A Bush; G Brusselle; John W Holloway
I have taken my umbrella, so of course it does not rain.
Thorax 2012;67(1):88-9.
2011: María Soler Artigas; Thor Aspelund; R Graham Barr; Inês Barroso; John Beilby; John D Blakey; Mladen Boban; H Marike Boezen; Vesna Boraska; Jonas Brisman; John R Britton; Guy G Brusselle; Gemma Cadby; Harry Campbell; Patricia A Cassano; Bruno H Ch Stricker; Cyrus Cooper; David J Couper; Ivan Curjuric; Santosh Dahgam; Ian J Deary; Shah Ebrahim; Mark Eijgelsheim; Gudny Eiriksdottir; Paul Elliott; David M Evans; Myriam Fornage; Nora Franceschini; Clyde Francks; Melissa Garcia; Darya Gaysina; Sina A Gharib; Christian Gieger; Gauti Kjartan Gislason; Sven Gläser; Raquel Granell; Ivica Grkovic; Xiangjun Gu; Vilmundur Gudnason; Ian P Hall; Christopher J Hammond; Dana B Hancock; John L Hankinson; Rebecca Hardy; Sarah E Harris; Tamara B Harris; Anna-Liisa Hartikainen; Caroline Hayward; Susan R Heckbert; Joachim Heinrich; Markku Heliövaara; John Henderson; Amanda Henry; Aroon D Hingorani; Albert Hofman; John W Holloway; Patrick G Holt; Georg Homuth; Jennifer E Huffman; Jennie Hui; Michael L Hunter; Pirro G Hysi; Medea Imboden; Catherine M Jackson; Alan L James; Karen A Jameson; Stipan Jankovic; Marjo-Riitta Järvelin; Deborah L Jarvis; Toby Johnson; Bonnie R Joubert; Mika Kähönen; Jaakko Kaprio; Stefan Karrasch; Shona M Kerr; Norman Klopp; Beate Koch; Ivana Kolcic; Stephen B Kritchevsky; Florian Kronenberg; Diana Kuh; Lenore J Launer; Debbie A Lawlor; Jason Z Liu; Yongmei Liu; Laura R Loehr; Kurt Lohman; Stephanie J London; Ruth J F Loos; Lorna M Lopez; Daan W Loth; Thomas Lumley; Massimo Mangino; Ani Manichaikul; Jonathan Marchini; Kristin D Marciante; Wendy L McArdle; Tricia McKeever; Bernd Meibohm; Andrew D Morris; Richard W Morris; Alanna C Morrison; Arthur W Musk; Kari E North; Fredrik Nyberg; Ma'en Obeidat; George T O'Connor; Anna-Carin Olin; Ernst Omenaas; Lyle J Palmer; Craig E Pennell; Kirsi H Pietiläinen; Isabelle Pin; Ozren Pola Sbreve Ek; David J Porteous; Dirkje S Postma; Anneli Pouta; Nicole Probst-Hensch; Bruce M Psaty; Adaikalavan Ramasamy; Taina Rantanen; Stephen S Rich; Susan M Ring; Samuli Ripatti; Fernando Rivadeneira; Thierry Rochat; Jerome I Rotter; Igor Rudan; Alicja R Rudnicka; Avan Aihie Sayer; Ian Sayers; Holger Schulz; So-Youn Shin; Peter D Sly; Albert Vernon Smith; George Davey Smith; Akshay Sood; Tim D Spector; John M Starr; David P Strachan; Ida Surakka; Wenbo Tang; André G Uitterlinden; Veronique Vitart; Henry Völzke; Judith M Vonk; Louise V Wain; S Goya Wannamethee; Nicholas J Wareham; Nicole M Warrington; Peter H Whincup; H-Erich Wichmann; cisca wijmenga; Sarah H Wild; Jemma B Wilk; O Dale Williams; James F Wilson; Matthias Wjst; Andrew Wong; Alan F Wright; Tatijana Zemunik; Lina Zgaga; Guangju Zhai; Jing Hua Zhao; Khalid A Al Balushi; Eva Albrecht; Melinda C Aldrich; Wei Q Ang; Martin D Tobin
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
Nature genetics 2011;43(11):1082-90.
2011: María Soler Artigas; Ida Surakka; Martin D Tobin; Louise V Wain; S Goya Wannamethee; Nicholas J Wareham; Peter H Whincup; Jing Hua Zhao; Eva Albrecht; Inês Barroso; John D Blakey; John R Britton; Paul R Burton; Gemma Cadby; Cyrus Cooper; Santosh Dahgam; Elaine Dennison; Anna F Dominiczak; Shah Ebrahim; Ian P Hall; Joachim Heinrich; Markku Heliövaara; Aroon D Hingorani; John W Holloway; Jennie Hui; Cathy M Jackson; Alan L James; Toby Johnson; Mika Kähönen; Stefan Karrasch; Shona M Kerr; Debbie A Lawlor; Jason Z Liu; Ruth J F Loos; Jonathan Marchini; Tricia M McKeever; Richard W Morris; Asa Torinsson Naluai; Fredrik Nyberg; Ma'en Obeidat; Anna-Carin Olin; Lyle J Palmer; Ian D Pavord; Emmanouela Repapi; Samuli Ripatti; Ian Sayers; Holger Schulz; Seif O Shaheen; Blair H Smith; George Davey Smith
Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function.
American journal of respiratory and critical care medicine 2011;184(7):786-95.
2011: Eric M Schauberger; Max A Seibold; Hongmei Zhang; Julie T Ziegler; S Hasan Arshad; Pedro C Avila; Sheila J Barton; Esteban González Burchard; Susan L Ewart; Karen H Friderici; Christopher Gignoux; Qutayba Hamid; Isaac T W Harley; John B Harley; Stephen T Holgate; John W Holloway; Donglei Hu; Marianne Huebner; Wilfried Karmaus; Jeffrey R Kilpatrick; Ramesh J Kurukulaaratchy; Stephane Lajoie-Kadoch; Carl D Langefeld; Stephanie J London; William Rodriguez-Cintrón; Jose R Rodriguez-Santana; Isabelle Romieu; Matthew J Rose-Zerilli; MARSHA WILLS-KARP
Identification of ATPAF1 as a novel candidate gene for asthma in children.
The Journal of allergy and clinical immunology 2011;128(4):753-760.e11.
2011: Cassandra Richardson; Matthew Rose-Zerilli; Javier Virues-Ortega; Rebecca J Webster; Ana Baya; Romola S Bucks; Alexandra M Hogan; John W Holloway; Fenella J Kirkham; Lyle J Palmer; Torsten Baldeweg
Neurophysiological evidence for cognitive and brain functional adaptation in adolescents living at high altitude.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2011;122(9):1726-34.
2011: Seif O Shaheen; Holly E Syddall; Avan Aihie Sayer; Barbara J Boucher; Cyrus Cooper; John W Holloway; Karen A Jameson; Sian M Robinson; Elaine M Dennison
Relationship of vitamin D status to adult lung function and COPD.
Thorax 2011;66(8):692-8.
2011: Hongmei Zhang; Yan D Zhao; Weichao Bao; Jianjun Gan; John W Holloway; Wilfried Karmaus; Dewi Rahardja; Martha Scott; Syed Hasan Arshad
Adjusting wheal size measures to correct atopy misclassification.
International journal of general medicine 2011;4():597-606.
2011: Yize I Wan; David P Strachan; David M Evans; John Henderson; Tricia McKeever; John W Holloway; Ian P Hall; Ian Sayers
A genome-wide association study to identify genetic determinants of atopy in subjects from the United Kingdom.
The Journal of allergy and clinical immunology 2011;127(1):223-31, 231.e1-3.
2011: K C Pike; Matthew J Rose-Zerilli; E Caffrey Osvald; Hazel Inskip; Keith M Godfrey; Sarah Crozier; Graham Roberts; JB Clough; John W Holloway; Jane S A Lucas
The relationship between infant lung function and the risk of wheeze in the preschool years.
Pediatric pulmonology 2011;46(1):75-82.
2010: Seif O Shaheen; Roger B Newson; Susan M Ring; Matthew J Rose-Zerilli; John W Holloway; A John Henderson
Prenatal and infant acetaminophen exposure, antioxidant gene polymorphisms, and childhood asthma.
The Journal of allergy and clinical immunology 2010;126(6):1141-8.e7.
2010: A John Henderson; Roger B Newson; M Rose-Zerilli; S M Ring; John W Holloway; Seif O Shaheen
Maternal Nrf2 and gluthathione-S-transferase polymorphisms do not modify associations of prenatal tobacco smoke exposure with asthma and lung function in school-aged children.
Thorax 2010;65(10):897-902.
2010: Jim Stevenson; Edmund Sonuga-Barke; Donna McCann; Kate Grimshaw; Karen M Parker; Matthew J Rose-Zerilli; John W Holloway; John O Warner
The role of histamine degradation gene polymorphisms in moderating the effects of food additives on children's ADHD symptoms.
The American journal of psychiatry 2010;167(9):1108-15.
2010: John W Holloway; S Hasan Arshad; Stephen T Holgate
Using genetics to predict the natural history of asthma?
The Journal of allergy and clinical immunology 2010;126(2):200-9; quiz 210-1.
2010: John W Holloway; Ross Laxton; Matthew J Rose-Zerilli; Judith A Holloway; A Lynn Andrews; Zeshan Riaz; Susan J Wilson; Iain A Simpson; Shu Ye
ADAM33 expression in atherosclerotic lesions and relationship of ADAM33 gene variation with atherosclerosis.
Atherosclerosis 2010;211(1):224-30.
2010: Rachel S Agbeko; John W Holloway; Meredith L Allen; Shu Ye; Katy J Fidler; John Pappachan; Allan Goldman; David Pontefract; John Deanfield; Nigel J Klein; Mark J Peters
Genetic polymorphisms in the endotoxin receptor may influence platelet count as part of the acute phase response in critically ill children.
Intensive care medicine 2010;36(6):1023-32.
2010: John W Holloway; S J Barton; I Sayers
Atopy susceptibility and chromosome 19q13.
Allergy 2010;65(6):802-4.
2010: Alexandra M Hogan; Javier Virues-Ortega; Ana Baya Botti; Romola S Bucks; John W Holloway; Matthew J Rose-Zerilli; Lyle J Palmer; Rebecca J Webster; Torsten Baldeweg; Fenella J Kirkham
Development of aptitude at altitude.
Developmental science 2010;13(3):533-44.
2010: Cosetta Minelli; Raquel Granell; Roger Newson; Matthew J Rose-Zerilli; Maties Torrent; Sue M Ring; John W Holloway; Seif O Shaheen; John A Henderson
Glutathione-S-transferase genes and asthma phenotypes: a Human Genome Epidemiology (HuGE) systematic review and meta-analysis including unpublished data.
International journal of epidemiology 2010;39(2):539-62.
2010: John W Holloway; Ian A Yang; Stephen T Holgate
Genetics of allergic disease.
The Journal of allergy and clinical immunology 2010;125(2 Suppl 2):S81-94.
2010: Emmanouela Repapi; Ian Sayers; Louise V Wain; Paul R Burton; Toby Johnson; Ma'en Obeidat; Jing Hua Zhao; Adaikalavan Ramasamy; Guangju Zhai; Veronique Vitart; Jennifer E Huffman; Wilmar Igl; Eva Albrecht; Panos Deloukas; John Henderson; Raquel Granell; Wendy L McArdle; Alicja R Rudnicka; Inês Barroso; Ruth J F Loos; Nicholas J Wareham; Linda Mustelin; Taina Rantanen; Ida Surakka; Medea Imboden; H Erich Wichmann; Ivica Grkovic; Stipan Jankovic; Lina Zgaga; Anna-Liisa Hartikainen; Leena Peltonen; Ulf Gyllensten; Asa Johansson; Ghazal Zaboli; Harry Campbell; Sarah H Wild; James F Wilson; Sven Gläser; Georg Homuth; Henry Völzke; Massimo Mangino; Nicole Soranzo; Tim D Spector; Ozren Polasek; Igor Rudan; Alan F Wright; Markku Heliövaara; Samuli Ripatti; Anneli Pouta; Åsa Torinsson Naluai; Anna-Carin Olin; Kjell Torén; Matthew N Cooper; Alan L James; Lyle J Palmer; Aroon D Hingorani; S Goya Wannamethee; Peter H Whincup; George Davey Smith; Shah Ebrahim; Tricia M McKeever; Ian D Pavord; Andrew K MacLeod; Andrew D Morris; David J Porteous; Cyrus Cooper; Elaine Dennison; Seif Shaheen; Stefan Karrasch; Eva Schnabel; Holger Schulz; Harald Grallert; Nabila Bouatia-Naji; Jérôme Delplanque; Philippe Froguel; John D Blakey; John R Britton; Richard W Morris; John W Holloway; Debbie A Lawlor; Jennie Hui; Fredrik Nyberg; Marjo-Riitta Jarvelin; Cathy Jackson; Mika Kähönen; Jaakko Kaprio; Nicole M Probst-Hensch; Beate Koch; Caroline Hayward; David M Evans; Paul Elliott; David P Strachan; Ian P Hall; Martin D Tobin
Genome-wide association study identifies five loci associated with lung function.
Nature genetics 2010;42(1):36-44.
2009: Gerard H Koppelman; Deborah A Meyers; Timothy D Howard; S Lilly Zheng; Gregory A Hawkins; Elizabeth J Ampleford; Jianfeng Xu; Henk Koning; Marcel Bruinenberg; Ilja M Nolte; Cleo C van Diemen; H Marike Boezen; Wim Timens; Paul A Whittaker; O Colin Stine; Sheila J Barton; John W Holloway; Stephen T Holgate; Penelope E Graves; Fernando D Martinez; Antoon J van Oosterhout; Eugene R Bleecker; Dirkje S Postma
Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness.
American journal of respiratory and critical care medicine 2009;180(10):929-35.
2009: John V Pappachan; Tim G Coulson; Nicholas J A Child; David J Markham; Sarah M Nour; Mark C K Pulletz; Matthew J Rose-Zerilli; Kim de Courcey-Golder; Sheila J Barton; Ian A Yang; John W Holloway
Mortality in adult intensive care patients with severe systemic inflammatory response syndromes is strongly associated with the hypo-immune TNF -238A polymorphism.
Immunogenetics 2009;61(10):657-62.
2009: Matthew J Rose-Zerilli; Sheila J Barton; A John Henderson; Seif O Shaheen; John W Holloway
Copy-number variation genotyping of GSTT1 and GSTM1 gene deletions by real-time PCR.
Clinical chemistry 2009;55(9):1680-5.
2009: Ian A Yang; Kwun M Fong; Paul V Zimmerman; Stephen T Holgate; John W Holloway
Genetic susceptibility to the respiratory effects of air pollution.
Postgraduate medical journal 2009;85(1006):428-36.
2009: Allison-Lynn Andrews; Ida Karin Nordgren; Isabelle Kirby; John W Holloway; Stephen T Holgate; Donna E Davies; Ali Tavassoli
Cytoplasmic tail of IL-13Ralpha2 regulates IL-4 signal transduction.
Biochemical Society transactions 2009;37(Pt 4):873-6.
2009: S Black; A S Teixeira; A X W Loh; L Vinall; John W Holloway; R Hardy; D M Swallow
Contribution of functional variation in the IL13 gene to allergy, hay fever and asthma in the NSHD longitudinal 1946 birth cohort.
Allergy 2009;64(8):1172-8.
2009: Cecilia M Lindgren; Iris M Heid; Joshua C Randall; Claudia Lamina; Valgerdur Steinthorsdottir; Lu Qi; Elizabeth K Speliotes; Gudmar Thorleifsson; Cristen J Willer; Blanca M Herrera; Anne U Jackson; Noha Lim; Paul Scheet; Nicole Soranzo; Najaf Amin; Yurii S Aulchenko; John C Chambers; Alexander Drong; Jian'an Luan; Helen N Lyon; Fernando Rivadeneira; Serena Sanna; Nicholas J Timpson; M Carola Zillikens; Jing Hua Zhao; Peter Almgren; Stefania Bandinelli; Amanda J Bennett; Richard N Bergman; Lori L Bonnycastle; Suzannah J Bumpstead; STEPHEN CHANOCK; Lynn Cherkas; Peter Chines; Lachlan Coin; Cyrus Cooper; Gabriel Crawford; Angela Doering; Anna Dominiczak; Alex S F Doney; Shah Ebrahim; Paul Elliott; Michael R Erdos; Karol Estrada; Luigi Ferrucci; Guido Fischer; Nita G Forouhi; Christian Gieger; Harald Grallert; Christopher J Groves; Scott Grundy; Candace Guiducci; David Hadley; Anders Hamsten; Aki S Havulinna; Albert Hofman; Rolf Holle; John W Holloway; Thomas Illig; Bo Isomaa; Leonie C Jacobs; Karen Jameson; Pekka Jousilahti; Fredrik Karpe; Johanna Kuusisto; Jaana Laitinen; G Mark Lathrop; Debbie A Lawlor; Massimo Mangino; Wendy L McArdle; Thomas Meitinger; Mario A Morken; Andrew P Morris; Patricia Munroe; Narisu Narisu; Anna Nordström; Peter Nordström; Ben A Oostra; Colin N A Palmer; Felicity Payne; John F Peden; Inga Prokopenko; Frida Renström; Aimo Ruokonen; Veikko Salomaa; Manjinder S Sandhu; Laura J Scott; ANGELO SCUTERI; Kaisa Silander; Kijoung Song; Xin Yuan; Heather M Stringham; Amy J Swift; Tiinamaija Tuomi; Manuela Uda; Peter Vollenweider; Gerard Waeber; Chris Wallace; Gudmundur Bragi Walters; Michael N Weedon; Jacqueline C M Witteman; Cuilin Zhang; Weihua Zhang; Mark J Caulfield; Francis S Collins; George Davey Smith; Ian N M Day; Paul W Franks; Andrew T Hattersley; Frank B Hu; Marjo-Riitta Jarvelin; Augustine Kong; Jaspal S Kooner; Markku Laakso; Edward Lakatta; Vincent Mooser; Andrew D Morris; Leena Peltonen; Nilesh J Samani; Timothy D Spector; David P Strachan; Toshiko Tanaka; Jaakko Tuomilehto; André G Uitterlinden; C.M. Duijn; Nicholas J Wareham; Dawn M Waterworth; Michael Boehnke; Panos Deloukas; Leif Groop; David J Hunter; Unnur Thorsteinsdottir; David Schlessinger; H-Erich Wichmann; Timothy M Frayling; Gonçalo R Abecasis; Joel N Hirschhorn; Ruth J F Loos; Kari Stefansson; Karen L Mohlke; Inês Barroso; Mark I McCarthy
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.
PLoS genetics 2009;5(6):e1000508.
2009: Sheila J Barton; Gerard H Koppelman; Judith M Vonk; Claudia A Browning; Ilja M Nolte; Ceri E Stewart; Sue Bainbridge; Stacey Mutch; Matthew J Rose-Zerilli; Dirkje S Postma; Nikolas Maniatis; Amanda P Henry; Ian P Hall; Stephen T Holgate; Patrick Tighe; John W Holloway; I Sayers
PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline.
The Journal of allergy and clinical immunology 2009;123(6):1391-400.e17.
2009: Hans Michael Haitchi; Hajime Yoshisue; A Ribbene; Susan J Wilson; John W Holloway; Fabio Bucchieri; N A Hanley; D I Wilson; G Zummo; Stephen T Holgate; Donna E Davies
Chronological expression of Ciliated Bronchial Epithelium 1 during pulmonary development.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2009;33(5):1095-104.
2009: Seung-Hyun Kim; Young-Min Ye; Gyu-Young Hur; Hyun-Young Lee; Young-Koo Jee; Seung-Ho Lee; John W Holloway; Hae-Sim Park
Effect of beta2-adrenergic receptor polymorphism in asthma control of patients receiving combination treatment.
Yonsei medical journal 2009;50(2):182-8.
2009: Catherine A Thornton; Judith Holloway; Janis K Shute; John W Holloway; Norma D Diaper; John O Warner
Human mid-gestation amniotic fluid contains interleukin-16 bioactivity.
Immunology 2009;126(4):543-51.
2009: S M Behrends; G E Carstens; T D A Forbes; H Lippke; R K Miller; R D Randel; F M Rouquette; BG Warrington; T H Welsh; J M Behrends; John W Holloway
Relationship of temperament, growth, carcass characteristics and tenderness in beef steers.
Meat science 2009;81(3):433-8.
2009: Aleksandra Szczepankiewicz; Matthew J Rose-Zerilli; Sheila J Barton; Stephen T Holgate; John W Holloway
Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic families.
International archives of allergy and immunology 2009;149(4):343-9.
2008: John W Holloway; Gerard H Koppelman
17q21 variants and asthma - questions and answers.
The New England journal of medicine 2008;359(19):2043-5.
2008: Alan Pemberton; Matthew J Rose-Zerilli; John W Holloway; Robert D Gray; Stephen T Holgate
A single-nucleotide polymorphism in intelectin 1 is associated with increased asthma risk.
The Journal of allergy and clinical immunology 2008;122(5):1033-4.
2008: John W Holloway; Sheila J Barton; Stephen T Holgate; Matthew J Rose-Zerilli; I Sayers
The role of LTA4H and ALOX5AP polymorphism in asthma and allergy susceptibility.
Allergy 2008;63(8):1046-53.
2008: Ian A Yang; Kwun M Fong; Paul V Zimmerman; Stephen T Holgate; John W Holloway
Genetic susceptibility to the respiratory effects of air pollution.
Thorax 2008;63(6):555-63.
2008: Youwen Yang; Hans Michael Haitchi; Julie A Cakebread; David Sammut; Anna Harvey; Robert M Powell; John W Holloway; Peter H Howarth; Stephen T Holgate; Donna E Davies
Epigenetic mechanisms silence a disintegrin and metalloprotease 33 expression in bronchial epithelial cells.
The Journal of allergy and clinical immunology 2008;121(6):1393-9, 1399.e1-14.
2008: John W Holloway; Ian A Yang; Stephen T Holgate
Interpatient variability in rates of asthma progression: can genetics provide an answer?
The Journal of allergy and clinical immunology 2008;121(3):573-9.
2008: A K Konstantinidis; Sarah M Puddicombe; A Mochizuki; P D Sheth; Ian A Yang; Hajime Yoshisue; Susan J Wilson; Donna E Davies; Stephen T Holgate; John W Holloway
Cellular localization of interleukin 13 receptor alpha2 in human primary bronchial epithelial cells and fibroblasts.
Journal of investigational allergology & clinical immunology : official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunología 2008;18(3):174-80.
2007: Ian A Yang; John W Holloway
Asthma: advancing gene-environment studies.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2007;37(9):1264-6.
2007: Allison-Lynn Andrews; Fabio Bucchieri; Kazuhiko Arima; Kenji Izuhara; Stephen T Holgate; Donna E Davies; John W Holloway
Effect of IL-13 receptor alpha2 levels on the biological activity of IL-13 variant R110Q.
The Journal of allergy and clinical immunology 2007;120(1):91-7.
2007: A K Konstantinidis; Sheila J Barton; I Sayers; Ian A Yang; James L Lordan; Steuart Rorke; JB Clough; Stephen T Holgate; John W Holloway
Genetic association studies of interleukin-13 receptor alpha1 subunit gene polymorphisms in asthma and atopy.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2007;30(1):40-7.
2007: Stephen T Holgate; Donna E Davies; Robert M Powell; Peter H Howarth; Hans Michael Haitchi; John W Holloway
Local genetic and environmental factors in asthma disease pathogenesis: chronicity and persistence mechanisms.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2007;29(4):793-803.
2007: Seung-Hyun Kim; Hae-Sim Park; John W Holloway; Hyoung Doo Shin; Choon-Sik Park
Association between a TGFbeta1 promoter polymorphism and rhinosinusitis in aspirin-intolerant asthmatic patients.
Respiratory medicine 2007;101(3):490-5.
2007: Ian A Yang; Santiyagu M Savarimuthu; Samuel T Kim; John W Holloway; Scott C Bell; Kwun M Fong
Gene-environmental interaction in asthma.
Current opinion in allergy and clinical immunology 2007;7(1):75-82.
2007: John W Holloway; Gerard H Koppelman
Identifying novel genes contributing to asthma pathogenesis.
Current opinion in allergy and clinical immunology 2007;7(1):69-74.
2006: Allison-Lynn Andrews; Tosia Nasir; Fabio Bucchieri; John W Holloway; Stephen T Holgate; Donna E Davies
IL-13 receptor alpha 2: a regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts.
The Journal of allergy and clinical immunology 2006;118(4):858-65.
2006: Sang-Hoon Kim; Young-Min Ye; Seong Kyu Lee; Jeong Hee Choi; John W Holloway; Choon-Sik Park; Hae-Sim Park
Association of TNF-alpha genetic polymorphism with HLA DPB1*0301.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2006;36(10):1247-53.
2006: Sang-Hoon Kim; J-S Bae; John W Holloway; J-T Lee; Chang-Hee Suh; Dong-Ho Nahm; Hae-Sim Park
A polymorphism of MS4A2 (- 109T > C) encoding the beta-chain of the high-affinity immunoglobulin E receptor (FcepsilonR1beta) is associated with a susceptibility to aspirin-intolerant asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2006;36(7):877-83.
2006: Stephen T Holgate; Youwen Yang; Hans Michael Haitchi; Robert M Powell; John W Holloway; Hajime Yoshisue; Yun Yun Pang; Julie A Cakebread; Donna E Davies
The genetics of asthma: ADAM33 as an example of a susceptibility gene.
Proceedings of the American Thoracic Society 2006;3(5):440-3.
2006: Karine Rousseau; Lynne E Vinall; Suzanne Butterworth; Rebecca J Hardy; John W Holloway; Michael E J Wadsworth; Dallas M Swallow
MUC7 haplotype analysis: results from a longitudinal birth cohort support protective effect of the MUC7*5 allele on respiratory function.
Annals of human genetics 2006;70(Pt 4):417-27.
2006: Allison-Lynn Andrews; John W Holloway; Stephen T Holgate; Donna E Davies
IL-4 receptor alpha is an important modulator of IL-4 and IL-13 receptor binding: implications for the development of therapeutic targets.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(12):7456-61.
2006: L Hao; I Sayers; Julie A Cakebread; Sheila J Barton; B Beghé; Stephen T Holgate; Tony Sampson; John W Holloway
The cysteinyl-leukotriene type 1 receptor polymorphism 927T/C is associated with atopy severity but not with asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2006;36(6):735-41.
2006: Stephen T Holgate; John W Holloway; Susan Wilson; Peter H Howarth; Hans Michael Haitchi; Suresh Babu; Donna E Davies
Understanding the pathophysiology of severe asthma to generate new therapeutic opportunities.
The Journal of allergy and clinical immunology 2006;117(3):496-506; quiz 507.
2006: Ian A Yang; Kwun M Fong; Stephen T Holgate; John W Holloway
The role of Toll-like receptors and related receptors of the innate immune system in asthma.
Current opinion in allergy and clinical immunology 2006;6(1):23-8.
2006: Kristin M Burkart; Sheila J Barton; John W Holloway; Ian A Yang; Julie A Cakebread; William W Cruikshank; Frédéric F Little; Xiaoyi Jin; Lindsay A Farrer; Joanne B Clough; Tim P Keith; Stephen Holgate; David M Center; George T O'Connor
Association of asthma with a functional promoter polymorphism in the IL16 gene.
The Journal of allergy and clinical immunology 2006;117(1):86-91.
2006: Stephen T Holgate; Donna E Davies; Robert M Powell; John W Holloway
ADAM33: a newly identified protease involved in airway remodelling.
Pulmonary pharmacology & therapeutics 2006;19(1):3-11.
2005: Seung-Hyun Kim; Jeong-Hee Choi; John W Holloway; Chang-Hee Suh; Dong-Ho Nahm; Eun-Ho Ha; Choon-Sik Park; Hae-Sim Park
Leukotriene-related gene polymorphisms in patients with aspirin-intolerant urticaria and aspirin-intolerant asthma: differing contributions of ALOX5 polymorphism in Korean population.
Journal of Korean medical science 2005;20(6):926-31.
2005: Stephen T Holgate; Donna E Davies; Robert M Powell; John W Holloway
ADAM33: a newly identified gene in the pathogenesis of asthma.
Immunology and allergy clinics of North America 2005;25(4):655-68.
2005: Nicola L Harris; John W Holloway; Penny Fitzharris; Michael McDonald; Mali Camberis; Barbara Fazekas De St Groth; franca ronchese; Graham Le Gros
Tissue localization and frequency of antigen-specific effector CD4 T cells determines the development of allergic airway inflammation.
Immunology and cell biology 2005;83(5):490-7.
2005: Angela Simpson; Nikolas Maniatis; Francine Jury; Julie A Cakebread; Lesley A Lowe; Stephen T Holgate; Ashley Woodcock; W E R Ollier; ANDREW COLLINS; Adnan Custovic; John W Holloway; Sally L John
Polymorphisms in a disintegrin and metalloprotease 33 (ADAM33) predict impaired early-life lung function.
American journal of respiratory and critical care medicine 2005;172(1):55-60.
2005: Sang-Hoon Kim; J-S Bae; Chang-Hee Suh; Dong-Ho Nahm; John W Holloway; Hae-Sim Park
Polymorphism of tandem repeat in promoter of 5-lipoxygenase in ASA-intolerant asthma: a positive association with airway hyperresponsiveness.
Allergy 2005;60(6):760-5.
2005: Mark D Steel; Sarah M Puddicombe; Lynnsey M Hamilton; Robert M Powell; John W Holloway; Stephen T Holgate; Donna E Davies; Jane E Collins
Beta-catenin/T-cell factor-mediated transcription is modulated by cell density in human bronchial epithelial cells.
The international journal of biochemistry & cell biology 2005;37(6):1281-95.
2005: Sang-Hoon Kim; Jeong Hee Choi; Hae-Sim Park; John W Holloway; Seong Kyu Lee; Choon-Sik Park; Hyoung Doo Shin
Association of thromboxane A2 receptor gene polymorphism with the phenotype of acetyl salicylic acid-intolerant asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2005;35(5):585-90.
2005: John W Holloway; Ian A Yang
Beta2-Adrenergic receptor polymorphism and asthma: true or false?
The Journal of allergy and clinical immunology 2005;115(5):960-2.
2005: S T Holgate; John W Holloway
Is big beautiful? The continuing story of ADAM33 and asthma.
Thorax 2005;60(4):263-4.
2005: Ian A Yang; Olaf Holz; Rudolf A Jörres; Helgo Magnussen; Sheila J Barton; Santiago Rodriguez; Julie A Cakebread; John W Holloway; Stephen T Holgate
Association of tumor necrosis factor-alpha polymorphisms and ozone-induced change in lung function.
American journal of respiratory and critical care medicine 2005;171(2):171-6.
2005: John W Holloway; Ian A Yang; Shu Ye
Variation in the toll-like receptor 4 gene and susceptibility to myocardial infarction.
Pharmacogenetics and genomics 2005;15(1):15-21.
2004: Hajime Yoshisue; Sarah M Puddicombe; Susan J Wilson; Hans Michael Haitchi; Robert M Powell; David I Wilson; Anita Pandit; Ann E Berger; Donna E Davies; Stephen T Holgate; John W Holloway
Characterization of ciliated bronchial epithelium 1, a ciliated cell-associated gene induced during mucociliary differentiation.
American journal of respiratory cell and molecular biology 2004;31(5):491-500.
2004: Innes Asher; Carlos E Baena-Cagnani; Attilio Boner; Giorgio Walter Canonica; Alexander Chuchalin; Adnan Custovic; Elif Dagli; Tari Haahtela; Matthias Haus; Michal Lemmo-Hoten; Stephen Holgate; John W Holloway; Patrick Holt; Arne Host; Yoji Iikura; S G O Johansson; Allen Kaplan; Marek Kowalski; Richard F Lockey; Charles Naspitz; Joseph Odhiambo; Johannes Ring; Joaquin Sastre; Katherine Venables; Pakit Vichyanond; Benjamin Volovitz; Ulrich Wahn; John Warner; Kevin Weiss; Nan-shan Zhong
World Allergy Organization guidelines for prevention of allergy and allergic asthma.
International archives of allergy and immunology 2004;135(1):83-92.
2004: John W Holloway; Donna E Davies; Robert Powell; Hans Michael Haitchi; Tim P Keith; Stephen T Holgate
The discovery and role of ADAM33, a new candidate gene for asthma.
Expert reviews in molecular medicine 2004;6(17):1-12.
2004: Stephen T Holgate; Donna E Davies; Steuart Rorke; Julie A Cakebread; Gillian Murphy; Robert M Powell; John W Holloway
ADAM 33 and its association with airway remodeling and hyperresponsiveness in asthma.
Clinical reviews in allergy & immunology 2004;27(1):23-34.
2004: T Iwanaga; Alan R McEuen; A F Walls; JB Clough; Tim P Keith; Steuart Rorke; Sheila J Barton; Stephen T Holgate; John W Holloway
Polymorphism of the mast cell chymase gene (CMA1) promoter region: lack of association with asthma but association with serum total immunoglobulin E levels in adult atopic dermatitis.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2004;34(7):1037-42.
2004: Robert M Powell; James Wicks; John W Holloway; Stephen T Holgate; Donna E Davies
The splicing and fate of ADAM33 transcripts in primary human airways fibroblasts.
American journal of respiratory cell and molecular biology 2004;31(1):13-21.
2004: J H Lee; H-S Park; S W Park; An-Soo Jang; Soo Taek Uh; Tai Youn Rhim; C-S Park; S-J Hong; S T Holgate; John W Holloway; Hyoung Doo Shin
ADAM33 polymorphism: association with bronchial hyper-responsiveness in Korean asthmatics.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2004;34(6):860-5.
2004: Julie A Cakebread; Hans Michael Haitchi; John W Holloway; Robert M Powell; Tim P Keith; Donna E Davies; Stephen T Holgate
The role of ADAM33 in the pathogenesis of asthma.
Springer seminars in immunopathology 2004;25(3-4):361-75.
2004: Ian A Yang; S T Holgate; John W Holloway
Toll-like receptor polymorphisms and allergic disease: interpreting the evidence from genetic studies.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2004;34(2):163-6.
2004: Stephen T Holgate; John W Holloway; Susan Wilson; Fabio Bucchieri; Sarah M Puddicombe; Donna E Davies
Epithelial-mesenchymal communication in the pathogenesis of chronic asthma.
Proceedings of the American Thoracic Society 2004;1(2):93-8.
2004: John W Holloway; Stephen T Holgate
Genetics.
Chemical immunology and allergy 2004;84():1-35.
2004: Ian A Yang; Sheila J Barton; Steuart Rorke; Julie A Cakebread; Tim P Keith; JB Clough; Stephen T Holgate; John W Holloway
Toll-like receptor 4 polymorphism and severity of atopy in asthmatics.
Genes and immunity 2004;5(1):41-5.
2004: B Beghé; Michele Padoan; C T Moss; Sheila J Barton; John W Holloway; Stephen T Holgate; W M Howell; Cristina E Mapp
Lack of association of HLA class I genes and TNF alpha-308 polymorphism in toluene diisocyanate-induced asthma.
Allergy 2004;59(1):61-4.
2003: Ian A Yang; John W Holloway; Shu Ye
TLR4 Asp299Gly polymorphism is not associated with coronary artery stenosis.
Atherosclerosis 2003;170(1):187-90.
2003: B Beghé; S Barton; Steuart Rorke; Q Peng; I Sayers; Tom R Gaunt; Tim P Keith; JB Clough; Stephen T Holgate; John W Holloway
Polymorphisms in the interleukin-4 and interleukin-4 receptor alpha chain genes confer susceptibility to asthma and atopy in a Caucasian population.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2003;33(8):1111-7.
2003: I Sayers; S Barton; Steuart Rorke; J Sawyer; Q Peng; B Beghé; S Ye; Tim P Keith; JB Clough; John W Holloway; Tony Sampson; Stephen T Holgate
Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2003;33(8):1103-10.
2003: Robert M Powell; Lynnsey M Hamilton; Stephen T Holgate; Donna E Davies; John W Holloway
ADAM33: a novel therapeutic target for asthma.
Expert opinion on therapeutic targets 2003;7(4):485-94.
2003: S T Holgate; Donna E Davies; Gillian Murphy; Robert M Powell; John W Holloway
ADAM 33: just another asthma gene or a breakthrough in understanding the origins of bronchial hyperresponsiveness?
Thorax 2003;58(6):466-9.
2003: N J A Child; Ian A Yang; M C K Pulletz; K de Courcy-Golder; Allison-Lynn Andrews; V J Pappachan; John W Holloway
Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome.
Biochemical Society transactions 2003;31(Pt 3):652-3.
2003: I Sayers; S Barton; Steuart Rorke; B Beghé; Brooke Hayward; Paul Van Eerdewegh; Tim P Keith; JB Clough; Shu Ye; John W Holloway; Tony Sampson; Stephen T Holgate
Allelic association and functional studies of promoter polymorphism in the leukotriene C4 synthase gene (LTC4S) in asthma.
Thorax 2003;58(5):417-24.
2002: Allison-Lynn Andrews; John W Holloway; Sarah M Puddicombe; Stephen T Holgate; Donna E Davies
Kinetic analysis of the interleukin-13 receptor complex.
The Journal of biological chemistry 2002;277(48):46073-8.
2002: Paul Van Eerdewegh; Randall D Little; Josée Dupuis; Richard G Del Mastro; Kathy Falls; Jason Simon; Dana Torrey; Sunil Pandit; Joyce McKenny; Karen Braunschweiger; Alison Walsh; Ziying Liu; Brooke Hayward; Colleen Folz; Susan P Manning; Alicia Bawa; Lisa Saracino; Michelle Thackston; Youssef Benchekroun; Neva Capparell; Mei Wang; Ron Adair; Yun Feng; JoAnn Dubois; Michael G FitzGerald; Hui Huang; René Gibson; Kristina M Allen; Alex Pedan; Melvyn R Danzig; Shelby P Umland; Robert W Egan; Francis M Cuss; Steuart Rorke; Joanne B Clough; John W Holloway; Stephen T Holgate; Tim P Keith
Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness.
Nature 2002;418(6896):426-30.
2002: James L Lordan; Fabio Bucchieri; Audrey Richter; Athanassias Konstantinidis; John W Holloway; Matthew Thornber; Sarah M Puddicombe; Diana Buchanan; Susan J Wilson; Ratko Djukanović; Stephen T Holgate; Donna E Davies
Cooperative effects of Th2 cytokines and allergen on normal and asthmatic bronchial epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(1):407-14.
2002: John W Holloway
In that case. A multi-national pharmaceutical company wishes to recruit some of your patients to a pharmaco-genetic study. Response.
New Zealand bioethics journal 2002;3(2):29-30.
2002: Catherine A Jones; Judith Holloway; Eleanor J Popplewell; Norma D Diaper; John W Holloway; G H S Vance; Jill A Warner; John O Warner
Reduced soluble CD14 levels in amniotic fluid and breast milk are associated with the subsequent development of atopy, eczema, or both.
The Journal of allergy and clinical immunology 2002;109(5):858-66.
2001: Lyle Palmer; Kathleen C Barnes; P R Burton; H Chen; W O Cookson; K A Deichmann; Robert C Elston; John W Holloway; K B Jacobs; T Laitinen; Matthias Wjst
Meta-analysis for linkage to asthma and atopy in the chromosome 5q31-33 candidate region.
Human molecular genetics 2001;10(8):891-99.
2001: John W Holloway; Christine Lonjou; B Beghé; Q Peng; Tom R Gaunt; I Gomes; I P Hall; J C Dewar; J Wilkinson; N S Thomas; Stephen T Holgate; Newton E Morton
Linkage analysis of the 5q31-33 candidate region for asthma in 240 UK families.
Genes and immunity 2001;2(1):20-4.
2001: Lyle Palmer; W O Cookson; KA Deichmann; John W Holloway; T Laitinen
Single region linkage analyses of asthma: description of data sets.
Genetic epidemiology 2001;21 Suppl 1():S9-15.
2001: Stephen T Holgate; Peter M Lackie; Peter H Howarth; William Roche; Sarah M Puddicombe; Audrey Richter; Susan J Wilson; John W Holloway; Donna E Davies
Invited lecture: activation of the epithelial mesenchymal trophic unit in the pathogenesis of asthma.
International archives of allergy and immunology 2001;124(1-3):253-8.
2001: L Palmer; Christine Lonjou; Kathleen C Barnes; H Chen; W O Cookson; KA Deichmann; John W Holloway; T Laitinen; Matthias Wjst; Newton E Morton
A retrospective collaboration on chromosome 5 by the International Consortium on Asthma Genetics (COAG).
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2001;31(1):152-4.
2000: Tony Sampson; siddiqui salman; D Buchanan; Peter H Howarth; Stephen T Holgate; John W Holloway; I Sayers
Variant LTC(4) synthase allele modifies cysteinyl leukotriene synthesis in eosinophils and predicts clinical response to zafirlukast.
Thorax 2000;55 Suppl 2():S28-31.
2000: Christine Lonjou; Kathleen C Barnes; H Chen; W O Cookson; KA Deichmann; I P Hall; John W Holloway; T Laitinen; Lyle Palmer; Matthias Wjst; Newton E Morton
A first trial of retrospective collaboration for positional cloning in complex inheritance: assay of the cytokine region on chromosome 5 by the consortium on asthma genetics (COAG).
Proceedings of the National Academy of Sciences of the United States of America 2000;97(20):10942-7.
2000: John W Holloway; P R Dunbar; G A Riley; G M Sawyer; Penny Fitzharris; N Pearce; Graham Le Gros; R Beasley
Association of beta2-adrenergic receptor polymorphisms with severe asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2000;30(8):1097-103.
2000: John W Holloway; S Ye; I N Day
Tools for molecular genetic epidemiology: a comparison of MADGE methodology with other systems.
Biotechnology & genetic engineering reviews 2000;17():71-88.
1999: L Camporota; John W Holloway
Interleukin-12 and allergic tissue response.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1999;29(10):1298-300.
1999: John W Holloway; B Beghé; Stephen T Holgate
The genetic basis of atopic asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1999;29(8):1023-32.
1999: S Salvi; Amanda E Semper; Anders Blomberg; John W Holloway; Zeina Jaffar; A Papi; LM Teran; R Polosa; F Kelly; Thomas Sandström; Stephen T Holgate; Anthony J Frew
Interleukin-5 production by human airway epithelial cells.
American journal of respiratory cell and molecular biology 1999;20(5):984-91.
1999: John W Holloway; B Beghé; S Turner; Lesley J Hinks; Ian N M Day; W Martin Howell
Comparison of three methods for single nucleotide polymorphism typing for DNA bank studies: sequence-specific oligonucleotide probe hybridisation, TaqMan liquid phase hybridisation, and microplate array diagonal gel electrophoresis (MADGE).
Human mutation 1999;14(4):340-7.
1999: Sarah Hook; P Cheng; John W Holloway; G Riley; G Sawyer; Graham Le Gros; R Beasley
Analysis of two IL-4 promoter polymorphisms in a cohort of atopic and asthmatic subjects.
Experimental and clinical immunogenetics 1999;16(1):33-5.
1998: Graham Le Gros; Klaus J Erb; N Harris; John W Holloway; K McCoy; franca ronchese
Immunoregulatory networks in asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1998;28 Suppl 5():92-6; discussion 117-8.
1998: K J Erb; John W Holloway; Alexandra Sobeck; Heidrun Moll; Graham Le Gros
Infection of mice with Mycobacterium bovis-Bacillus Calmette-Guérin (BCG) suppresses allergen-induced airway eosinophilia.
The Journal of experimental medicine 1998;187(4):561-9.
1996: John W Holloway; I Doull; B Begishvili; R Beasley; Stephen T Holgate; W M Howell
Lack of evidence of a significant association between HLA-DR, DQ and DP genotypes and atopy in families with HDM allergy.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1996;26(10):1142-9.
1996: Klaus J Erb; John W Holloway; Graham Le Gros
Mast cells in the front line. Innate immunity.
Current biology : CB 1996;6(8):941-2.
1991: W A Phillips; John W Holloway; Samuel W Coleman
Effect of pre- and postweaning management system on the performance on Brahman crossbred feeder calves.
Journal of animal science 1991;69(8):3102-11.