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Robert Homer

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Won-Kyung Cho; Jack A Elias; Frank J Giordano; Robert J Homer; Yan Huang; Min-Jong Kang; Chang-Min Lee; Patty J Lee; William C Sessa; Terence K Trow; Chun Geun Lee
IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension.
Huanxing Sun; Angara Sureshbabu; Shuang Yu; Richard Bucala; Rayman Choo-Wing; Juan Fan; Robert J Homer; Dianhua Jiang; Lin Leng; Paul Noble; Vineet Bhandari
A critical regulatory role for macrophage migration inhibitory factor in hyperoxia-induced injury in the developing murine lung.
Vineet Bhandari; Rayman Choo-Wing; Anantha Krishnan Harijith; Robert J Homer; Huanxing Sun; Mansoor Ali Syed; Jack A Elias
Increased hyperoxia-induced lung injury in nitric oxide synthase 2 null mice is mediated via angiopoietin 2.

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2013: Won-Kyung Cho; Jack A Elias; Frank J Giordano; Robert J Homer; Yan Huang; Min-Jong Kang; Chang-Min Lee; Patty J Lee; William C Sessa; Terence K Trow; Chun Geun Lee
IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension.
American journal of physiology. Lung cellular and molecular physiology 2013;304(2):L112-24.
2013: Huanxing Sun; Angara Sureshbabu; Shuang Yu; Richard Bucala; Rayman Choo-Wing; Juan Fan; Robert J Homer; Dianhua Jiang; Lin Leng; Paul Noble; Vineet Bhandari
A critical regulatory role for macrophage migration inhibitory factor in hyperoxia-induced injury in the developing murine lung.
PloS one 2013;8(4):e60560.
2012: Vineet Bhandari; Rayman Choo-Wing; Anantha Krishnan Harijith; Robert J Homer; Huanxing Sun; Mansoor Ali Syed; Jack A Elias
Increased hyperoxia-induced lung injury in nitric oxide synthase 2 null mice is mediated via angiopoietin 2.
American journal of respiratory cell and molecular biology 2012;46(5):668-76.
2012: Valsamo K Anagnostou; Gerold Bepler; Daniel Boffa; Taxiarchis Botsis; Frank C Detterbeck; Anastasios T Dimou; Dimitrios Dougenis; Scott N Gettinger; Mark D Gustavson; Robert J Homer; Elizabeth J Killiam; Konstantinos N Syrigos; Lynn T Tanoue; Vassiliki Zolota; David L Rimm
Molecular classification of nonsmall cell lung cancer using a 4-protein quantitative assay.
Cancer 2012;118(6):1607-18.
2012: Danielle Antin-Ozerkis; Janine Evans; Robert J Homer; Ami Rubinowitz; RA Matthay
Interstitial lung disease in the connective tissue diseases.
Clinics in chest medicine 2012;33(1):123-49.
2011: Frank C Detterbeck; Robert J Homer
Approach to the ground-glass nodule.
Clinics in chest medicine 2011;32(4):799-810.
2011: Charlotte Mitchell; Naiqian Niu; Karin Provost; Robert J Homer; Lauren Cohn
IFN-γ acts on the airway epithelium to inhibit local and systemic pathology in allergic airway disease.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(7):3815-20.
2011: Lilia Mijares; Caroline Sokol; Tamding Wangdi; Robert J Homer; Ruslan Medzhitov; Barbara I Kazmierczak
Airway epithelial MyD88 restores control of Pseudomonas aeruginosa murine infection via an IL-1-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(12):7080-8.
2011: Hiroshi Matsuura; Yang Zhou; Charles Dela Cruz; Won Kyoo Cho; Geoffrey L Chupp; Jack A Elias; Dominik Hartl; Robert J Homer; Min-Jong Kang; Barbara Koller; Chun Geun Lee
Role of breast regression protein-39 in the pathogenesis of cigarette smoke-induced inflammation and emphysema.
American journal of respiratory cell and molecular biology 2011;44(6):777-86.
2011: Bing Ma; Charles Dela Cruz; Dominik Hartl; Min-Jong Kang; Shervin Takyar; Robert J Homer; Chun Geun Lee; Jack A Elias
RIG-like helicase innate immunity inhibits vascular endothelial growth factor tissue responses via a type I IFN-dependent mechanism.
American journal of respiratory and critical care medicine 2011;183(10):1322-35.
2011: Anantha Krishnan Harijith; Rayman Choo-Wing; Sule Cataltepe; Ryuji Yasumatsu; Zubair H Aghai; Joakim Janér; Sture Andersson; Robert J Homer; Vineet Bhandari
A role for matrix metalloproteinase 9 in IFNγ-mediated injury in developing lungs: relevance to bronchopulmonary dysplasia.
American journal of respiratory cell and molecular biology 2011;44(5):621-30.
2010: Paulette L Wright; Jun Yu; Y P Peter Di; Robert J Homer; Geoffrey L Chupp; Jack A Elias; Lauren Cohn; William C Sessa
Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation.
The Journal of experimental medicine 2010;207(12):2595-607.
2010: Robert J Homer; Erica L Herzog
Recent advances in pulmonary fibrosis: implications for scleroderma.
Current opinion in rheumatology 2010;22(6):683-9.
2010: Danielle Antin-Ozerkis; Janine Evans; Ami Rubinowitz; Robert J Homer; RA Matthay
Pulmonary manifestations of rheumatoid arthritis.
Clinics in chest medicine 2010;31(3):451-78.
2010: Valsamo K Anagnostou; Frank J Lowery; Vassiliki Zolota; Vassiliki Tzelepi; Arun Gopinath; Camil Liceaga; Nikolaos Panagopoulos; Konstantina Frangia; Lynn T Tanoue; Daniel Boffa; Scott Gettinger; Frank C Detterbeck; Robert J Homer; Dimitrios Dougenis; David L Rimm; Konstantinos N Syrigos
High expression of BCL-2 predicts favorable outcome in non-small cell lung cancer patients with non squamous histology.
BMC cancer 2010;10():186.
2009: Susan K Mathai; Ami N Rubinowitz; Robert J Homer; Frank C Detterbeck; Erica L Herzog
Of lungs, lipids, and lollipops.
Chest 2009;136(5):1420-3.
2009: Naiqian Niu; Terri Laufer; Robert J Homer; Lauren Cohn
Cutting edge: Limiting MHC class II expression to dendritic cells alters the ability to develop Th2- dependent allergic airway inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(3):1523-7.
2009: Valsamo K Anagnostou; Gerold Bepler; Konstantinos N Syrigos; Lynn T Tanoue; Scott Gettinger; Robert J Homer; Daniel Boffa; Frank C Detterbeck; David L Rimm
High expression of mammalian target of rapamycin is associated with better outcome for patients with early stage lung adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(12):4157-64.
2009: Ana I Caceres; Marian Brackmann; Maxwell D Elia; Bret F Bessac; Donato Del Camino; Marc D'Amours; JoAnn S Witek; Chistopher M Fanger; Jayhong A Chong; Neil J Hayward; Robert J Homer; Lauren Cohn; Xiaozhu Huang; Magdalene M Moran; Sven-Eric Jordt
A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(22):9099-104.
2009: Terence K Trow; D G Morris; C R Miller; Robert J Homer
Granulomatous bronchiolitis of Crohn's disease successfully treated with inhaled budesonide.
Thorax 2009;64(6):546-7.
2009: Chun Geun Lee; Dominik Hartl; Gap Ryol Lee; Barbara Koller; Hiroshi Matsuura; Carla A Da Silva; Myung Hyun Sohn; Lauren Cohn; Robert J Homer; Alexander A Kozhich; Alison A Humbles; Jennifer Kearley; Anthony J Coyle; Geoffrey L Chupp; Jennifer L Reed; Richard A Flavell; Jack A Elias
Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis.
The Journal of experimental medicine 2009;206(5):1149-66.
2009: Valsamo K Anagnostou; Konstantinos SYRIGOS; Gerold Bepler; Robert J Homer; David L Rimm
Thyroid transcription factor 1 is an independent prognostic factor for patients with stage I lung adenocarcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(2):271-8.
2008: Chun Geun Lee; Dominik Hartl; Hiroshi Matsuura; Felicity M Dunlop; Pierre D Scotney; Louis J Fabri; Andrew D Nash; ningyuan chen; Chu-Yan Tang; Qingsheng Chen; Robert J Homer; Manuel Baca; Jack A Elias
Endogenous IL-11 signaling is essential in Th2- and IL-13-induced inflammation and mucus production.
American journal of respiratory cell and molecular biology 2008;39(6):739-46.
2008: Dominik Hartl; Chuan Hua He; Barbara Koller; Carla A Da Silva; Robert J Homer; Chun G Lee; Jack A Elias
Acidic mammalian chitinase is secreted via an ADAM17/epidermal growth factor receptor-dependent pathway and stimulates chemokine production by pulmonary epithelial cells.
The Journal of biological chemistry 2008;283(48):33472-82.
2008: Vineet Bhandari; Rayman Choo-Wing; Chun Geun Lee; Kamran Yusuf; Jonathan H Nedrelow; Namasivayam Ambalavanan; Herbert Malkus; Robert J Homer; Jack A Elias
Developmental regulation of NO-mediated VEGF-induced effects in the lung.
American journal of respiratory cell and molecular biology 2008;39(4):420-30.
2008: Ami N Rubinowitz; Marianne Moon; Robert J Homer
A 34-year-old man presenting with gradual onset of shortness of breath and interstitial lung disease.
Chest 2008;133(4):1041-7.
2008: Masashi Yamasaki; Hye-Ryun Kang; Robert J Homer; Svetlana Chapoval; Soo Jung Cho; Byung Jae Lee; Jack A Elias; Chun Geun Lee
P21 regulates TGF-beta1-induced pulmonary responses via a TNF-alpha-signaling pathway.
American journal of respiratory cell and molecular biology 2008;38(3):346-53.
2007: Svetlana Chapoval; Amal Al-Garawi; Jose M Lora; Ian Strickland; Bing Ma; Patty J Lee; Robert J Homer; Sankar Ghosh; Anthony J Coyle; Jack A Elias
Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(10):7030-41.
2007: Barton Kenney; Jorge Dotto; Robert J Homer; Nelofar Shafi; Larisa Davydova
Primary malignant melanoma of the transverse colon: report of a case and review of the literature.
International journal of surgical pathology 2007;15(4):401-7.
2007: Rayman Choo-Wing; Jonathan H Nedrelow; Robert J Homer; Jack A Elias; Vineet Bhandari
Developmental differences in the responses of IL-6 and IL-13 transgenic mice exposed to hyperoxia.
American journal of physiology. Lung cellular and molecular physiology 2007;293(1):L142-50.
2007: Hye-Ryun Kang; Chun Geun Lee; Robert J Homer; Jack A Elias
Semaphorin 7A plays a critical role in TGF-beta1-induced pulmonary fibrosis.
The Journal of experimental medicine 2007;204(5):1083-93.
2007: Vineet Bhandari; Rayman Choo-Wing; Robert J Homer; Jack A Elias
Increased hyperoxia-induced mortality and acute lung injury in IL-13 null mice.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):4993-5000.
2007: Naiqian Niu; Marc K Le Goff; Fangyong Li; Marina Rahman; Robert J Homer; Lauren Cohn
A novel pathway that regulates inflammatory disease in the respiratory tract.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(6):3846-55.
2007: Hye-Ryun Kang; Soo Jung Cho; Chun Geun Lee; Robert J Homer; Jack A Elias
Transforming growth factor (TGF)-beta1 stimulates pulmonary fibrosis and inflammation via a Bax-dependent, bid-activated pathway that involves matrix metalloproteinase-12.
The Journal of biological chemistry 2007;282(10):7723-32.
2007: Min Jong Kang; Robert J Homer; Amy Gallo; Chun Geun Lee; Kristina Crothers; Soo Jung Cho; Carolyn L Rochester; Hilary Cain; Geoffrey L Chupp; Ho Joo Yoon; Jack A Elias
IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(3):1948-59.
2007: Barton Kenney; Marguerite Pinto; Robert J Homer
Benign pulmonary epithelial inclusions within the pleura: a case report.
Diagnostic pathology 2007;2():21.
2007: Ulla-Angela Temann; Yasmina Laouar; Elizabeth E Eynon; Robert J Homer; Richard A Flavell
IL9 leads to airway inflammation by inducing IL13 expression in airway epithelial cells.
International immunology 2007;19(1):1-10.
2006: Vineet Bhandari; Rayman Choo-Wing; Chun Geun Lee; Zhou Zhu; Jonathan H Nedrelow; Geoffrey L Chupp; Xucher Zhang; Michael A Matthay; Lorraine B Ware; Robert J Homer; Patty J Lee; Anke Geick; Antonin R de Fougerolles; Jack A Elias
Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death.
Nature medicine 2006;12(11):1286-93.
2006: N Khazeni; Robert J Homer; Ami N Rubinowitz; Geoffrey L Chupp
Massive cavitary pulmonary rheumatoid nodules in a patient with HIV.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2006;28(4):872-4.
2006: Robert J Homer; Zhou Zhu; Lauren Cohn; Chun Gun Lee; Wendy I White; Suping Chen; Jack A Elias
Differential expression of chitinases identify subsets of murine airway epithelial cells in allergic inflammation.
American journal of physiology. Lung cellular and molecular physiology 2006;291(3):L502-11.
2006: Min Jong Kang; Chun Geun Lee; Soo Jung Cho; Robert J Homer; Jack A Elias
IFN-gamma-dependent DNA injury and/or apoptosis are critical in cigarette smoke-induced murine emphysema.
Proceedings of the American Thoracic Society 2006;3(6):517-8.
2006: Jack A Elias; Min Jong Kang; Kristina Crothers; Kristina Crouthers; Robert J Homer; Chun Geun Lee
State of the art. Mechanistic heterogeneity in chronic obstructive pulmonary disease: insights from transgenic mice.
Proceedings of the American Thoracic Society 2006;3(6):494-8.
2006: Chun Geun Lee; Soojung Cho; Robert J Homer; Jack A Elias
Genetic control of transforming growth factor-beta1-induced emphysema and fibrosis in the murine lung.
Proceedings of the American Thoracic Society 2006;3(6):476-477.
2006: Vineet Bhandari; Rayman Choo-Wing; Svetlana Chapoval; Chun Geun Lee; C Tang; Yoon-Keun Kim; Bing Ma; Peter Baluk; Michelle I Lin; Donald M McDonald; Robert J Homer; William C Sessa; Jack A Elias
Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(29):11021-6.
2006: Chun Geun Lee; Hye-Ryun Kang; Robert J Homer; Geoffrey L Chupp; Jack A Elias
Transgenic modeling of transforming growth factor-beta(1): role of apoptosis in fibrosis and alveolar remodeling.
Proceedings of the American Thoracic Society 2006;3(5):418-23.
2006: Bing Ma; Michael R Blackburn; Chun Geun Lee; Robert J Homer; Wei Liu; Richard A Flavell; Lynn Boyden; Richard P Lifton; Chun-Xiao Sun; Hays W J Young; Jack A Elias
Adenosine metabolism and murine strain-specific IL-4-induced inflammation, emphysema, and fibrosis.
The Journal of clinical investigation 2006;116(5):1274-83.
2006: Bing Ma; Wei Liu; Robert J Homer; Patty J Lee; Anthony J Coyle; Jose M Lora; Chun Geun Lee; Jack A Elias
Role of CCR5 in the pathogenesis of IL-13-induced inflammation and remodeling.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(8):4968-78.
2006: Soo Jung Cho; Min Jong Kang; Robert J Homer; Hye-Ryun Kang; Xuchen Zhang; Patty J Lee; Jack A Elias; Chun Geun Lee
Role of early growth response-1 (Egr-1) in interleukin-13-induced inflammation and remodeling.
The Journal of biological chemistry 2006;281(12):8161-8.
2006: Patty J Lee; Xuchen Zhang; Peiying Shan; Bing Ma; Chun Geun Lee; Robert J Homer; Zhou Zhu; Mercedes Rincon; Brooke T Mossman; Jack A Elias
ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo.
The Journal of clinical investigation 2006;116(1):163-73.
2005: Bing Ma; Min Jong Kang; Chun Geun Lee; Svetlana Chapoval; Wei Liu; Qingsheng Chen; Anthony J Coyle; Jose M Lora; Dominic Picarella; Robert J Homer; Jack A Elias
Role of CCR5 in IFN-gamma-induced and cigarette smoke-induced emphysema.
The Journal of clinical investigation 2005;115(12):3460-72.
2005: Paul W Noble; Lynn Tanoue; Robert J Homer
Case study review.
Chest 2005;128(5 Suppl 1):540S-546S.
2005: Dianhua Jiang; Jiurong Liang; Juan Fan; Shuang Yu; Suping Chen; Yi Luo; Glenn D Prestwich; Marcella M Mascarenhas; Hari G Garg; Deborah A Quinn; Robert J Homer; Daniel R Goldstein; Richard Bucala; Patty J Lee; Ruslan Medzhitov; Paul W Noble
Regulation of lung injury and repair by Toll-like receptors and hyaluronan.
Nature medicine 2005;11(11):1173-9.
2005: Xuchen Zhang; Peiying Shan; Salman Qureshi; Robert J Homer; Ruslan Medzhitov; Paul W Noble; Patty J Lee
Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(8):4834-8.
2005: Jack A Elias; Robert J Homer; Qutayba Hamid; Chun Geun Lee
Chitinases and chitinase-like proteins in T(H)2 inflammation and asthma.
The Journal of allergy and clinical immunology 2005;116(3):497-500.
2005: Paul W Noble; Robert J Homer
Back to the future: historical perspective on the pathogenesis of idiopathic pulmonary fibrosis.
American journal of respiratory cell and molecular biology 2005;33(2):113-20.
2005: Tao Zheng; Min Jong Kang; Kristina Crothers; Zhou Zhu; Wei Liu; Chun Geun Lee; Lesley A Rabach; Harold A Chapman; Robert J Homer; David Aldous; George T De Sanctis; George Desanctis; Stephen Underwood; Michael Graupe; Richard A Flavell; John A Schmidt; Jack A Elias
Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(12):8106-15.
2005: Chuan Hua He; Aaron B Waxman; Chun Geun Lee; Holger W Link; Morgan E Rabach; Bing Ma; Qingsheng Chen; Zhou Zhu; Mei Zhong; Keiko Nakayama; Keiichi I Nakayama; Robert J Homer; Jack A Elias
Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury.
The Journal of clinical investigation 2005;115(4):1039-48.
2005: Qingsheng Chen; Lesley A Rabach; Paul Noble; Tao Zheng; Chun Geun Lee; Robert J Homer; Jack A Elias
IL-11 receptor alpha in the pathogenesis of IL-13-induced inflammation and remodeling.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(4):2305-13.
2005: Robert J Homer; Jack A Elias
Airway remodeling in asthma: therapeutic implications of mechanisms.
Physiology (Bethesda, Md.) 2005;20():28-35.
2004: Paul W Noble; Robert J Homer
Idiopathic pulmonary fibrosis: new insights into pathogenesis.
Clinics in chest medicine 2004;25(4):749-58, vii.
2004: Ivana Kawikova; Vipin Paliwal; Marian Szczepanik; Atsuko Itakura; Mieko Fukui; Regis A Campos; Gregory P Geba; Robert J Homer; Bettina P Iliopoulou; Jordan S Pober; Ryohei F Tsuji; Philip W Askenase
Airway hyper-reactivity mediated by B-1 cell immunoglobulin M antibody generating complement C5a at 1 day post-immunization in a murine hapten model of non-atopic asthma.
Immunology 2004;113(2):234-45.
2004: Chun Geun Lee; Holger W Link; Peter Baluk; Robert J Homer; Svetlana Chapoval; Vineet Bhandari; Min Jong Kang; Lauren Cohn; Yoon-Keun Kim; Donald M McDonald; Jack A Elias
Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung.
Nature medicine 2004;10(10):1095-103.
2004: Chun Geun Lee; Soo Jung Cho; Min Jong Kang; Svetlana Chapoval; Patty J Lee; Paul W Noble; Teshome Yehualaeshet; Binfeng Lu; Richard A Flavell; Jeffrey Milbrandt; Robert J Homer; Jack A Elias
Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis.
The Journal of experimental medicine 2004;200(3):377-89.
2004: Dianhua Jiang; Jiurong Liang; Jennifer Hodge; Bao Lu; Zhou Zhu; Shuang Yu; Juan Fan; Yunfei Gao; Zhinan Yin; Robert J Homer; Craig Gerard; Paul W Noble
Regulation of pulmonary fibrosis by chemokine receptor CXCR3.
The Journal of clinical investigation 2004;114(2):291-9.
2004: Zhou Zhu; Tao Zheng; Robert J Homer; Yoon-Keun Kim; ningyuan chen; Lauren Cohn; Qutayba Hamid; Jack A Elias
Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation.
Science (New York, N.Y.) 2004;304(5677):1678-82.
2004: Bing Ma; Zhou Zhu; Robert J Homer; Craig Gerard; Robert M Strieter; Jack A Elias
The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(3):1872-81.
2003: Jingming Wang; Qingsheng Chen; Jonathan Corne; Zhou Zhu; Chun Geun Lee; Vineet Bhandari; Robert J Homer; Jack A Elias
Pulmonary expression of leukemia inhibitory factor induces B cell hyperplasia and confers protection in hyperoxia.
The Journal of biological chemistry 2003;278(33):31226-32.
2003: Tao Zheng; Zhou Zhu; Wei Liu; Chun Geun Lee; Qingsheng Chen; Robert J Homer; Jack A Elias
Cytokine regulation of IL-13Ralpha2 and IL-13Ralpha1 in vivo and in vitro.
The Journal of allergy and clinical immunology 2003;111(4):720-8.
2003: Zhou Zhu; Goran Enhorning; Tao Zheng; Qingsheng Chen; ningyuan chen; Robert J Homer; Jack A Elias
Interleukin-13 induces surfactant function abnormality in the murine lung.
Chest 2003;123(3 Suppl):375S-6S.
2003: Jack A Elias; Tao Zheng; Chun Geun Lee; Robert J Homer; Qingsheng Chen; Bing Ma; Michael Blackburn; Zhou Zhu
Transgenic modeling of interleukin-13 in the lung.
Chest 2003;123(3 Suppl):339S-45S.
2003: Jack A Elias; Chun Geun Lee; Tao Zheng; Bing Ma; Robert J Homer; Zhou Zhu
New insights into the pathogenesis of asthma.
The Journal of clinical investigation 2003;111(3):291-7.
2002: Laurie A Whittaker; Naiqian Niu; Ulla-Angela Temann; Amy Stoddard; Richard A Flavell; Anuradha Ray; Robert J Homer; Lauren Cohn
Interleukin-13 mediates a fundamental pathway for airway epithelial mucus induced by CD4 T cells and interleukin-9.
American journal of respiratory cell and molecular biology 2002;27(5):593-602.
2002: Chun Geun Lee; Robert J Homer; Lauren Cohn; Holger W Link; Sungsoo Jung; Joseph E Craft; Barney S Graham; Teresa Johnson; Jack A Elias
Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways.
The Journal of biological chemistry 2002;277(38):35466-74.
2002: Sophie Lanone; Tao Zheng; Zhou Zhu; Wei Liu; Chun Geun Lee; Bing Ma; Qingsheng Chen; Robert J Homer; Jingming Wang; Lesley A Rabach; Morgan E Rabach; J Michael Shipley; Steven D Shapiro; Robert M Senior; Jack A Elias
Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling.
The Journal of clinical investigation 2002;110(4):463-74.
2002: Robert J Homer; Tao Zheng; Geoffrey L Chupp; Susan He; Zhou Zhu; Quingshen Chen; Bing Ma; R Duncan Hite; Laurice I Gobran; Seamus A Rooney; Jack A Elias
Pulmonary type II cell hypertrophy and pulmonary lipoproteinosis are features of chronic IL-13 exposure.
American journal of physiology. Lung cellular and molecular physiology 2002;283(1):L52-9.
2002: Zhou Zhu; Tao Zheng; Chun Geun Lee; Robert J Homer; Jack A Elias
Tetracycline-controlled transcriptional regulation systems: advances and application in transgenic animal modeling.
Seminars in cell & developmental biology 2002;13(2):121-8.
2002: Zhou Zhu; Bing Ma; Tao Zheng; Robert J Homer; Chun Geun Lee; Israel F Charo; Paul Noble; Jack A Elias
IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(6):2953-62.
2002: Lauren Cohn; Laurie A Whittaker; Naiqian Niu; Robert J Homer
Cytokine regulation of mucus production in a model of allergic asthma.
Novartis Foundation symposium 2002;248():201-13; discussion 213-20, 277-82.
2001: Zhou Zhu; Chun Geun Lee; Tao Zheng; Geoffrey L Chupp; Jingming Wang; Robert J Homer; Paul W Noble; Qutayba Hamid; Jack A Elias
Airway inflammation and remodeling in asthma. Lessons from interleukin 11 and interleukin 13 transgenic mice.
American journal of respiratory and critical care medicine 2001;164(10 Pt 2):S67-70.
2001: Tao Zheng; Zhou Zhu; Jingming Wang; Robert J Homer; Jack A Elias
IL-11: insights in asthma from overexpression transgenic modeling.
The Journal of allergy and clinical immunology 2001;108(4):489-96.
2001: Chun Geun Lee; Robert J Homer; Zhou Zhu; Sophie Lanone; X Wang; V Koteliansky; J Michael Shipley; Philip J Gotwals; Paul Noble; Quingshen Chen; Robert M Senior; Jack A Elias
Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1).
The Journal of experimental medicine 2001;194(6):809-21.
2001: Zhou Zhu; Bing Ma; Robert J Homer; Tao Zheng; Jack A Elias
Use of the tetracycline-controlled transcriptional silencer (tTS) to eliminate transgene leak in inducible overexpression transgenic mice.
The Journal of biological chemistry 2001;276(27):25222-9.
2001: Lauren Cohn; Christina A Herrick; Naiqian Niu; Robert J Homer; Kim Bottomly
IL-4 promotes airway eosinophilia by suppressing IFN-gamma production: defining a novel role for IFN-gamma in the regulation of allergic airway inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2760-7.
2000: Z Wang; Tao Zheng; Zhou Zhu; Robert J Homer; Richard J Riese; Harold A Chapman; Steven D Shapiro; Jack A Elias
Interferon gamma induction of pulmonary emphysema in the adult murine lung.
The Journal of experimental medicine 2000;192(11):1587-600.
2000: Tao Zheng; Zhou Zhu; Z Wang; Robert J Homer; Bing Ma; Richard J Riese; Harold A Chapman; Steven D Shapiro; Jack A Elias
Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema.
The Journal of clinical investigation 2000;106(9):1081-93.
2000: Jingming Wang; Robert J Homer; Qingsheng Chen; Jack A Elias
Endogenous and exogenous IL-6 inhibit aeroallergen-induced Th2 inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(7):4051-61.
2000: J Corne; Geoffrey L Chupp; Chun Geun Lee; Robert J Homer; Zhou Zhu; Quingshen Chen; Bing Ma; Y Du; F Roux; J McArdle; Aaron B Waxman; Jack A Elias
IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury.
The Journal of clinical investigation 2000;106(6):783-91.
2000: Jingming Wang; Robert J Homer; L Hong; Lauren Cohn; Chun Geun Lee; S Jung; Jack A Elias
IL-11 selectively inhibits aeroallergen-induced pulmonary eosinophilia and Th2 cytokine production.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(4):2222-31.
2000: Robert J Homer; Jack A Elias
Consequences of long-term inflammation. Airway remodeling.
Clinics in chest medicine 2000;21(2):331-43, ix.
2000: N S Ward; Aaron B Waxman; Robert J Homer; Lin L Mantell; O Einarsson; Y Du; Jack A Elias
Interleukin-6-induced protection in hyperoxic acute lung injury.
American journal of respiratory cell and molecular biology 2000;22(5):535-42.
1999: Lauren Cohn; Robert J Homer; Naiqian Niu; Kim Bottomly
T helper 1 cells and interferon gamma regulate allergic airway inflammation and mucus production.
The Journal of experimental medicine 1999;190(9):1309-18.
1999: DH Zhang; L Yang; Lauren Cohn; L Parkyn; Robert J Homer; Prabir Ray; Anuradha Ray
Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3.
Immunity 1999;11(4):473-82.
1999: Jack A Elias; Zhou Zhu; Geoffrey L Chupp; Robert J Homer
Airway remodeling in asthma.
The Journal of clinical investigation 1999;104(8):1001-6.
1999: Aaron B Waxman; O Einarsson; T Seres; Roy Knickelbein; Robert J Homer; JB Warshaw; R Johnston; Jack A Elias
Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation.
Chest 1999;116(1 Suppl):8S-9S.
1999: Lauren Cohn; Robert J Homer; H MacLeod; M Mohrs; F Brombacher; Kim Bottomly
Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(10):6178-83.
1999: Zhou Zhu; Robert J Homer; Z Wang; Quingshen Chen; Gregory P Geba; Jingming Wang; Y Zhang; Jack A Elias
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production.
The Journal of clinical investigation 1999;103(6):779-88.
1998: Robert J Homer
Antineutrophil cytoplasmic antibodies as markers for systemic autoimmune disease.
Clinics in chest medicine 1998;19(4):627-39, viii.
1998: L Yang; Lauren Cohn; DH Zhang; Robert J Homer; Anuradha Ray; Prabir Ray
Essential role of nuclear factor kappaB in the induction of eosinophilia in allergic airway inflammation.
The Journal of experimental medicine 1998;188(9):1739-50.
1998: Aaron B Waxman; O Einarsson; T Seres; Roy Knickelbein; JB Warshaw; R Johnston; Robert J Homer; Jack A Elias
Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation.
The Journal of clinical investigation 1998;101(9):1970-82.
1997: Lauren Cohn; Robert J Homer; A Marinov; J Rankin; Kim Bottomly
Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production.
The Journal of experimental medicine 1997;186(10):1737-47.
1997: Prabir Ray; W Tang; Peili Wang; Robert J Homer; C Kuhn; Richard A Flavell; Jack A Elias
Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and -independent phenotypes.
The Journal of clinical investigation 1997;100(10):2501-11.
1997: D Trawick; A Kotch; RA Matthay; Robert J Homer
Eosinophilic pneumonia as a presentation of occult chronic granulomatous disease.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1997;10(9):2166-70.
1996: W Tang; Gregory P Geba; Tao Zheng; Prabir Ray; Robert J Homer; C Kuhn; Richard A Flavell; Jack A Elias
Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction.
The Journal of clinical investigation 1996;98(12):2845-53.
1996: Carrie A Redlich; Robert J Homer; Brian R Smith; J A Wirth; Mark R Cullen
Immunologic responses to isocyanates in sensitized asthmatic subjects.
Chest 1996;109(3 Suppl):6S-8S.
1995: Robert J Homer; L Khoo; G J Smith
Diffuse panbronchiolitis in a Hispanic man with travel history to Japan.
Chest 1995;107(4):1176-8.
1994: M A Azrin; F S Ling; Q Chen; A Pawashe; F Migliaccio; Robert J Homer; M Todd; M D Ezekowitz
Preparation, characterization, and evaluation of a monoclonal antibody against the rabbit platelet glycoprotein IIb/IIIa in an experimental angioplasty model.
Circulation research 1994;75(2):268-77.
1993: Robert J Homer; Clio Mamalaki; Dimitris Kioussis; Richard A Flavell
T cell unresponsiveness correlates with quantitative TCR levels in a transgenic model.
International immunology 1993;5(12):1495-500.