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Dirk Geerts

Research Profile

Disorders

Neuroblastoma

Chemicals & Drugs

Anatomy

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Publications

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Lisette P Yco; Dirk Geerts; Jan Koster; André S Bachmann
PRAF2 stimulates cell proliferation and migration and predicts poor prognosis in neuroblastoma.
Dana-Lynn T Koomoa; Jan Koster; Ingo Lange; Anthony E Pegg; David J Feith; Dirk Geerts; André S Bachmann
DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma.
Joanna E Gawecka; Dirk Geerts; Jan Koster; John Opoku-Ansah; André S Bachmann; Maisel J Caliva; Florian J Sulzmaier; Randal K Wada; Joe W Ramos
PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.

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All Publications

2013: Lisette P Yco; Dirk Geerts; Jan Koster; André S Bachmann
PRAF2 stimulates cell proliferation and migration and predicts poor prognosis in neuroblastoma.
International journal of oncology 2013;42(4):1408-16.
2013: Dana-Lynn T Koomoa; Jan Koster; Ingo Lange; Anthony E Pegg; David J Feith; Dirk Geerts; André S Bachmann
DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma.
International journal of oncology 2013;42(4):1219-28.
2012: Joanna E Gawecka; Dirk Geerts; Jan Koster; John Opoku-Ansah; André S Bachmann; Maisel J Caliva; Florian J Sulzmaier; Randal K Wada; Joe W Ramos
PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.
International journal of cancer. Journal international du cancer 2012;131(7):1556-68.
2012: F J Sulzmaier; M K G Valmiki; E P White; M J Caliva; Dirk Geerts; M L Matter; D A Nelson; Joe W Ramos
PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D.
Oncogene 2012;31(30):3547-60.
2011: Bjørn Helge Haug; Jørn R Henriksen; Per Kogner; Tommy Martinsson; Baldur Sveinbjørnsson; Ellen Tømte; Jochen Buechner; Trond Flaegstad; Dirk Geerts; Christer Einvik
MYCN-regulated miRNA-92 inhibits secretion of the tumor suppressor DICKKOPF-3 (DKK3) in neuroblastoma.
Carcinogenesis 2011;32(7):1005-12.
2010: Tamás Borsics; Emma Lundberg; Dirk Geerts; Dana-Lynn Takeko Koomoa; Jan Koster; Kenneth Wester; André S Bachmann
Subcellular distribution and expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in malignant glioma: Influence on cell survival and migration.
Cancer science 2010;101(7):1624-31.
2010: J J Molenaar; M E Ebus; J Koster; E Santo; Dirk Geerts; Rogier Versteeg; Huib N Caron
Cyclin D1 is a direct transcriptional target of GATA3 in neuroblastoma tumor cells.
Oncogene 2010;29(18):2739-45.
2010: Dirk Geerts; Jan Koster; David Albert; Dana-Lynn Takeko Koomoa; David J Feith; Anthony E Pegg; Richard Volckmann; Huib N Caron; Rogier Versteeg; André S Bachmann
The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification.
International journal of cancer. Journal international du cancer 2010;126(9):2012-24.
2010: Ingrid Revet; Gerda Huizenga; Jan Koster; Richard Volckmann; Peter G van Sluis; Rogier Versteeg; Dirk Geerts
MSX1 induces the Wnt pathway antagonist genes DKK1, DKK2, DKK3, and SFRP1 in neuroblastoma cells, but does not block Wnt3 and Wnt5A signalling to DVL3.
Cancer letters 2010;289(2):195-207.
2010: Gerben Schaaf; Mohamed Hamdi; Danny Zwijnenburg; Arjan Lakeman; Dirk Geerts; Rogier Versteeg; Marcel Kool
Silencing of SPRY1 triggers complete regression of rhabdomyosarcoma tumors carrying a mutated RAS gene.
Cancer research 2010;70(2):762-71.
2009: Jan J Molenaar; Marli E Ebus; Dirk Geerts; Jan Koster; Fieke Lamers; Linda J Valentijn; Ellen M Westerhout; Rogier Versteeg; Huib N Caron
Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(31):12968-73.
2008: Ingrid Revet; Gerda Huizenga; Alvin Chan; Jan Koster; Richard Volckmann; Peter G van Sluis; Ingrid Øra; Rogier Versteeg; Dirk Geerts
The MSX1 homeobox transcription factor is a downstream target of PHOX2B and activates the Delta-Notch pathway in neuroblastoma.
Experimental cell research 2008;314(4):707-19.
2007: Dirk Geerts; Christopher J Wallick; Dana-Lynn Takeko Koomoa; Jan Koster; Rogier Versteeg; Ramon Christopher V Go; André S Bachmann
Expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in neuroblastoma: correlation with clinical features, cellular localization, and cerulenin-mediated apoptosis regulation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(21):6312-9.
2007: Hinco J Gierman; Mireille H G Indemans; Jan Koster; Sandra Goetze; Jurgen Seppen; Dirk Geerts; Roel Van Driel; Rogier Versteeg
Domain-wide regulation of gene expression in the human genome.
Genome research 2007;17(9):1286-95.
2007: Jørn R Henriksen; Cecilie Løkke; Martin Hammerø; Dirk Geerts; Rogier Versteeg; Trond Flaegstad; Christer Einvik
Comparison of RNAi efficiency mediated by tetracycline-responsive H1 and U6 promoter variants in mammalian cell lines.
Nucleic acids research 2007;35(9):e67.
2006: Peter J M Stroeken; Belén Alvarez; Jacco van Rheenen; Yvonne M Wijnands; Dirk Geerts; Kees Jalink; Ed Roos
Integrin cytoplasmic domain-associated protein-1 (ICAP-1) interacts with the ROCK-I kinase at the plasma membrane.
Journal of cellular physiology 2006;208(3):620-8.
2005: Dirk Geerts; Ingrid Revet; Gerda Jorritsma; Nathalie Schilderink; Rogier Versteeg
MEIS homeobox genes in neuroblastoma.
Cancer letters 2005;228(1-2):43-50.
2003: Dirk Geerts; Nathalie Schilderink; Gerda Jorritsma; Rogier Versteeg
The role of the MEIS homeobox genes in neuroblastoma.
Cancer letters 2003;197(1-2):87-92.
2003: Lionel Fontao; Bertrand Favre; Sara Riou; Dirk Geerts; Fabienne Jaunin; Jean-Hilaire Saurat; Kathleen J Green; Arnoud Sonnenberg; Luca Borradori
Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus.
Molecular biology of the cell 2003;14(5):1978-92.
2003: Jan Koster; Dirk Geerts; Bertrand Favre; Luca Borradori; Arnoud Sonnenberg
Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.
Journal of cell science 2003;116(Pt 2):387-99.
2002: Haquima El Mourabit; Patrice Poinat; Jan Koster; Holger Sondermann; Viktor Wixler; Elmar Wegener; Emmanuel Laplantine; Dirk Geerts; Elisabeth Georges-Labouesse; Arnoud Sonnenberg; Monique Aumailley
The PDZ domain of TIP-2/GIPC interacts with the C-terminus of the integrin alpha5 and alpha6 subunits.
Matrix biology : journal of the International Society for Matrix Biology 2002;21(2):207-14.
2002: Arjan van der Flier; Ingrid Kuikman; Duco Kramer; Dirk Geerts; Maaike Kreft; Toshiro Takafuta; Sandor S Shapiro; Arnoud Sonnenberg
Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits.
The Journal of cell biology 2002;156(2):361-76.
2001: Lionel Fontao; Dirk Geerts; Ingrid Kuikman; Jan Koster; Duco Kramer; Arnoud Sonnenberg
The interaction of plectin with actin: evidence for cross-linking of actin filaments by dimerization of the actin-binding domain of plectin.
Journal of cell science 2001;114(Pt 11):2065-76.
2000: Viktor Wixler; Dirk Geerts; Emmanuel Laplantine; D Westhoff; Neil Smyth; Monique Aumailley; Arnoud Sonnenberg; Mats Paulsson
The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes.
The Journal of biological chemistry 2000;275(43):33669-78.
2000: MG Nievers; Ingrid Kuikman; Dirk Geerts; Irene M Leigh; Arnoud Sonnenberg
Formation of hemidesmosome-like structures in the absence of ligand binding by the (alpha)6(beta)4 integrin requires binding of HD1/plectin to the cytoplasmic domain of the (beta)4 integrin subunit.
Journal of cell science 2000;113 ( Pt 6)():963-73.
2000: Peter J M Stroeken; EA van Rijthoven; E Boer; Dirk Geerts; Ed Roos
Cytoplasmic domain mutants of beta1 integrin, expressed in beta 1-knockout lymphoma cells, have distinct effects on adhesion, invasion and metastasis.
Oncogene 2000;19(9):1232-8.
1999: Dirk Geerts; Lionel Fontao; MG Nievers; RQ Schaapveld; Patricia Purkis; G N Wheeler; E B Lane; Irene M Leigh; Arnoud Sonnenberg
Binding of integrin alpha6beta4 to plectin prevents plectin association with F-actin but does not interfere with intermediate filament binding.
The Journal of cell biology 1999;147(2):417-34.
1999: Arnoud Sonnenberg; MG Nievers; RQ Schaapveld; Dirk Geerts; CM Niessen; Luca Borradori
Interaction of BP180 and alpha6beta4.
The Journal of investigative dermatology 1999;112(5):830-2.
1999: Viktor Wixler; Emmanuel Laplantine; Dirk Geerts; Arnoud Sonnenberg; D Petersohn; Beate Eckes; Mats Paulsson; Monique Aumailley
Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains.
FEBS letters 1999;445(2-3):351-5.
1998: RQ Schaapveld; Luca Borradori; Dirk Geerts; MR van Leusden; Ingrid Kuikman; MG Nievers; CM Niessen; R D Steenbergen; P J Snijders; Arnoud Sonnenberg
Hemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180.
The Journal of cell biology 1998;142(1):271-84.
1998: MG Nievers; RQ Schaapveld; Lauran Oomen; Lionel Fontao; Dirk Geerts; Arnoud Sonnenberg
Ligand-independent role of the beta 4 integrin subunit in the formation of hemidesmosomes.
Journal of cell science 1998;111 ( Pt 12)():1659-72.