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Ellen Duysen

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Wei Jiang; Ellen G Duysen; Oksana Lockridge
Mice treated with a nontoxic dose of chlorpyrifos oxon have diethoxyphosphotyrosine labeled proteins in blood up to 4 days post exposure, detected by mass spectrometry.
Ellen G Duysen; Patrick Masson; Florian Nachon; Lawrence M Schopfer; John R Cashman; Oksana Lockridge
Differential sensitivity of plasma carboxylesterase-null mice to parathion, chlorpyrifos and chlorpyrifos oxon, but not to diazinon, dichlorvos, diisopropylfluorophosphate, cresyl saligenin phosphate, cyclosarin thiocholine, tabun thiocholine, and carbofuran.
Ellen G Duysen; Frank Koentgen; Lawrence M Schopfer; Christopher M Timperley; Gareth R Williams; Douglas M Cerasoli; Oksana Lockridge
Production of ES1 plasma carboxylesterase knockout mice for toxicity studies.

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All Publications

2012: Wei Jiang; Ellen G Duysen; Oksana Lockridge
Mice treated with a nontoxic dose of chlorpyrifos oxon have diethoxyphosphotyrosine labeled proteins in blood up to 4 days post exposure, detected by mass spectrometry.
Toxicology 2012;295(1-3):15-22.
2012: Ellen G Duysen; Patrick Masson; Florian Nachon; Lawrence M Schopfer; John R Cashman; Oksana Lockridge
Differential sensitivity of plasma carboxylesterase-null mice to parathion, chlorpyrifos and chlorpyrifos oxon, but not to diazinon, dichlorvos, diisopropylfluorophosphate, cresyl saligenin phosphate, cyclosarin thiocholine, tabun thiocholine, and carbofuran.
Chemico-biological interactions 2012;195(3):189-98.
2011: Ellen G Duysen; Frank Koentgen; Lawrence M Schopfer; Christopher M Timperley; Gareth R Williams; Douglas M Cerasoli; Oksana Lockridge
Production of ES1 plasma carboxylesterase knockout mice for toxicity studies.
Chemical research in toxicology 2011;24(11):1891-8.
2011: Ellen G Duysen; Oksana Lockridge
Induction of plasma acetylcholinesterase activity in mice challenged with organophosphorus poisons.
Toxicology and applied pharmacology 2011;255(2):214-20.
2011: Ellen G Duysen; Oksana Lockridge
Prolonged toxic effects after cocaine challenge in butyrylcholinesterase/plasma carboxylesterase double knockout mice: a model for butyrylcholinesterase-deficient humans.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(8):1321-3.
2011: Michael Adler; Ellen G Duysen; Tracey A Hamilton; Oksana Lockridge; Angela L Purcell; Richard E Sweeney; Sharad S Deshpande
Role of acetylcholinesterase on the structure and function of cholinergic synapses: insights gained from studies on knockout mice.
Cellular and molecular neurobiology 2011;31(6):909-20.
2011: Kalpana Parikh; Ellen G Duysen; Benjamin Snow; Neil S Jensen; Veeraswamy Manne; Oksana Lockridge; Nageswararao Chilukuri
Gene-delivered butyrylcholinesterase is prophylactic against the toxicity of chemical warfare nerve agents and organophosphorus compounds.
The Journal of pharmacology and experimental therapeutics 2011;337(1):92-101.
2011: Ellen G Duysen; K Parikh; V Aleti; V Manne; Oksana Lockridge; N Chilukuri
Adenovirus-mediated human paraoxonase1 gene transfer to provide protection against the toxicity of the organophosphorus pesticide toxicant diazoxon.
Gene therapy 2011;18(3):250-7.
2010: Shelley Camp; Limin Zhang; Eric Krejci; Alexandre Dobbertin; Véronique Bernard; Emmanuelle Girard; Ellen G Duysen; Oksana Lockridge; Antonella De Jaco; Palmer Taylor
Contributions of selective knockout studies to understanding cholinesterase disposition and function.
Chemico-biological interactions 2010;187(1-3):72-7.
2010: Andrea Gaydess; Ellen G Duysen; Yuan Li; Vladimir Gilman; Alexander Kabanov; Oksana Lockridge; Tatiana Bronich
Visualization of exogenous delivery of nanoformulated butyrylcholinesterase to the central nervous system.
Chemico-biological interactions 2010;187(1-3):295-8.
2010: Wei Jiang; Ellen G Duysen; Heidi Hansen; Luda Shlyakhtenko; Lawrence M Schopfer; Oksana Lockridge
Mice treated with chlorpyrifos or chlorpyrifos oxon have organophosphorylated tubulin in the brain and disrupted microtubule structures, suggesting a role for tubulin in neurotoxicity associated with exposure to organophosphorus agents.
Toxicological sciences : an official journal of the Society of Toxicology 2010;115(1):183-93.
2010: Anna Hrabovska; Vladimir Farar; Veronique Bernard; Ellen G Duysen; Jiri Brabec; Oksana Lockridge; Jaromir Myslivecek
Drastic decrease in dopamine receptor levels in the striatum of acetylcholinesterase knock-out mouse.
Chemico-biological interactions 2010;183(1):194-201.
2009: Hasmik Grigoryan; Lawrence M Schopfer; Eric S Peeples; Ellen G Duysen; Marine Grigoryan; Charles M Thompson; Oksana Lockridge
Mass spectrometry identifies multiple organophosphorylated sites on tubulin.
Toxicology and applied pharmacology 2009;240(2):149-58.
2009: Nageswararao Chilukuri; Ellen G Duysen; Kalpana Parikh; Robert diTargiani; Bhupendra P Doctor; Oksana Lockridge; Ashima Saxena
Adenovirus-transduced human butyrylcholinesterase in mouse blood functions as a bioscavenger of chemical warfare nerve agents.
Molecular pharmacology 2009;76(3):612-7.
2009: Noel D Johnson; Ellen G Duysen; Oksana Lockridge
Intrathecal delivery of fluorescent labeled butyrylcholinesterase to the brains of butyrylcholinesterase knock-out mice: visualization and quantification of enzyme distribution in the brain.
Neurotoxicology 2009;30(3):386-92.
2009: Ellen G Duysen; Bin Li; Oksana Lockridge
The butyrylcholinesterase knockout mouse a research tool in the study of drug sensitivity, bio-distribution, obesity and Alzheimer's disease.
Expert opinion on drug metabolism & toxicology 2009;5(5):523-8.
2009: Runa S Naik; Joachim Hartmann; Cornelia Kiewert; Ellen G Duysen; Oksana Lockridge; Jochen Klein
Effects of rivastigmine and donepezil on brain acetylcholine levels in acetylcholinesterase-deficient mice.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques 2009;12(1):79-85.
2008: Ellen G Duysen; Bin Li; Michaela Carlson; Yi-Fan Li; Stacy Wieseler; Steven H Hinrichs; Oksana Lockridge
Increased hepatotoxicity and cardiac fibrosis in cocaine-treated butyrylcholinesterase knockout mice.
Basic & clinical pharmacology & toxicology 2008;103(6):514-21.
2008: Nageswararao Chilukuri; Ellen G Duysen; Kalpana Parikh; Wei Sun; Bhupendra P Doctor; Oksana Lockridge; Ashima Saxena
Adenovirus-mediated gene transfer of human butyrylcholinesterase results in persistent high-level transgene expression in vivo.
Chemico-biological interactions 2008;175(1-3):327-31.
2008: Ellen G Duysen; Oksana Lockridge
Whole body and tissue imaging of the butyrylcholinesterase knockout mouse injected with near infrared dye labeled butyrylcholinesterase.
Chemico-biological interactions 2008;175(1-3):119-24.
2008: Bin Li; Ellen G Duysen; Oksana Lockridge
The butyrylcholinesterase knockout mouse is obese on a high-fat diet.
Chemico-biological interactions 2008;175(1-3):88-91.
2008: Joachim Hartmann; Cornelia Kiewert; Ellen G Duysen; Oksana Lockridge; Jochen Klein
Choline availability and acetylcholine synthesis in the hippocampus of acetylcholinesterase-deficient mice.
Neurochemistry international 2008;52(6):972-8.
2008: Bin Li; Ellen G Duysen; Michaela Carlson; Oksana Lockridge
The butyrylcholinesterase knockout mouse as a model for human butyrylcholinesterase deficiency.
The Journal of pharmacology and experimental therapeutics 2008;324(3):1146-54.
2007: Jaromír Myslivecek; Ellen G Duysen; Oksana Lockridge
Adaptation to excess acetylcholine by downregulation of adrenoceptors and muscarinic receptors in lungs of acetylcholinesterase knockout mice.
Naunyn-Schmiedeberg's archives of pharmacology 2007;376(1-2):83-92.
2007: Stephen G Rice; Lee Nowak; Ellen G Duysen; Oksana Lockridge; Debomoy K Lahiri; Patricio Reyes
Neuropathological and immunochemical studies of brain parenchyma in acetylcholinesterase knockout mice: implications in Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2007;11(4):481-9.
2007: Ellen G Duysen; Bin Li; Sultan Darvesh; Oksana Lockridge
Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission.
Toxicology 2007;233(1-3):60-9.
2007: Joachim Hartmann; Cornelia Kiewert; Ellen G Duysen; Oksana Lockridge; Nigel H Greig; Jochen Klein
Excessive hippocampal acetylcholine levels in acetylcholinesterase-deficient mice are moderated by butyrylcholinesterase activity.
Journal of neurochemistry 2007;100(5):1421-9.
2006: Bin Li; Ellen G Duysen; Larisa Poluektova; Leonard Murrin; Oksana Lockridge
Protection from the toxicity of diisopropylfluorophosphate by adeno-associated virus expressing acetylcholinesterase.
Toxicology and applied pharmacology 2006;214(2):152-65.
2006: Bin Li; Ellen G Duysen; Thomas L Saunders; Oksana Lockridge
Production of the butyrylcholinesterase knockout mouse.
Journal of molecular neuroscience : MN 2006;30(1-2):193-5.
2006: Ellen G Duysen; Oksana Lockridge
Phenotype comparison of three acetylcholinesterase knockout strains.
Journal of molecular neuroscience : MN 2006;30(1-2):91-2.
2006: Bin Li; Ellen G Duysen; Oksana Lockridge
Gene transfer of acetylcholinesterase protects the knockout mouse from the toxicity of DFP.
Journal of molecular neuroscience : MN 2006;30(1-2):79-80.
2005: Anna Hrabovska; Ellen G Duysen; Jeff D Sanders; Leonard Murrin; Oksana Lockridge
Delivery of human acetylcholinesterase by adeno-associated virus to the acetylcholinesterase knockout mouse.
Chemico-biological interactions 2005;157-158():71-8.
2005: Bin Li; Meghan Sedlacek; Indumathi Manoharan; Rathnam Boopathy; Ellen G Duysen; Patrick Masson; Oksana Lockridge
Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasma.
Biochemical pharmacology 2005;70(11):1673-84.
2005: Oksana Lockridge; Charles M Thompson; Troy Voelker; Ellen G Duysen; Lawrence M Schopfer
Life without acetylcholinesterase: the implications of cholinesterase inhibitor toxicity in AChE-knockout mice.
Environmental toxicology and pharmacology 2005;19(3):463-9.
2005: Eric S Peeples; Lawrence M Schopfer; Ellen G Duysen; Reggie S Spaulding; Troy Voelker; Charles M Thompson; Oksana Lockridge
Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry.
Toxicological sciences : an official journal of the Society of Toxicology 2005;83(2):303-12.
2004: Michael Adler; Heather A Manley; Angela L Purcell; Sharad S Deshpande; Tracey A Hamilton; Robert K Kan; George A Oyler; Oksana Lockridge; Ellen G Duysen; Robert E Sheridan
Reduced acetylcholine receptor density, morphological remodeling, and butyrylcholinesterase activity can sustain muscle function in acetylcholinesterase knockout mice.
Muscle & nerve 2004;30(3):317-27.
2004: Yuxia Wang; Lawrence M Schopfer; Ellen G Duysen; Florian Nachon; Patrick Masson; Oksana Lockridge
Screening assays for cholinesterases resistant to inhibition by organophosphorus toxicants.
Analytical biochemistry 2004;329(1):131-8.
2004: Yuxia Wang; Andreea Ticu Boeck; Ellen G Duysen; Margaret Van Keuren; Thomas L Saunders; Oksana Lockridge
Resistance to organophosphorus agent toxicity in transgenic mice expressing the G117H mutant of human butyrylcholinesterase.
Toxicology and applied pharmacology 2004;196(3):356-66.
2003: Laura A Volpicelli-Daley; Anna Hrabovska; Ellen G Duysen; Shawn M Ferguson; Randy D Blakely; Oksana Lockridge; Allan Levey
Altered striatal function and muscarinic cholinergic receptors in acetylcholinesterase knockout mice.
Molecular pharmacology 2003;64(6):1309-16.
2003: Laura A Volpicelli-Daley; Ellen G Duysen; Oksana Lockridge; Allan Levey
Altered hippocampal muscarinic receptors in acetylcholinesterase-deficient mice.
Annals of neurology 2003;53(6):788-96.
2003: Bin Li; Ellen G Duysen; Laura A Volpicelli-Daley; Allan Levey; Oksana Lockridge
Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice.
Pharmacology, biochemistry, and behavior 2003;74(4):977-86.
2002: Ellen G Duysen; Debra L Fry; Oksana Lockridge
Early weaning and culling eradicated Helicobacter hepaticus from an acetylcholinesterase knockout 129S6/SvEvTac mouse colony.
Comparative medicine 2002;52(5):461-6.
2002: Ellen G Duysen; Cynthia F Bartels; Oksana Lockridge
Wild-type and A328W mutant human butyrylcholinesterase tetramers expressed in Chinese hamster ovary cells have a 16-hour half-life in the circulation and protect mice from cocaine toxicity.
The Journal of pharmacology and experimental therapeutics 2002;302(2):751-8.
2002: Ellen G Duysen; Judith A Stribley; Debra L Fry; Steven H Hinrichs; Oksana Lockridge
Rescue of the acetylcholinesterase knockout mouse by feeding a liquid diet; phenotype of the adult acetylcholinesterase deficient mouse.
Brain research. Developmental brain research 2002;137(1):43-54.
2002: Marek-Marsel Mesulam; Angela L Guillozet; Pamela Shaw; Allan Levey; Ellen G Duysen; Oksana Lockridge
Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine.
Neuroscience 2002;110(4):627-39.
2001: Ellen G Duysen; B Li; W Xie; Lawrence M Schopfer; R S Anderson; Clarence A Broomfield; Oksana Lockridge
Evidence for nonacetylcholinesterase targets of organophosphorus nerve agent: supersensitivity of acetylcholinesterase knockout mouse to VX lethality.
The Journal of pharmacology and experimental therapeutics 2001;299(2):528-35.
2001: J Przybyszewski; AL Yaktine; Ellen G Duysen; D Blackwood; Weiqun Wang; Angela Au; Diane F Birt
Inhibition of phorbol ester-induced AP-1-DNA binding, c-Jun protein and c-jun mRNA by dietary energy restriction is reversed by adrenalectomy in SENCAR mouse epidermis.
Carcinogenesis 2001;22(9):1421-7.
2001: Diane F Birt; Ellen G Duysen; Weiqun Wang; AL Yaktine
Corticosterone supplementation reduced selective protein kinase C isoform expression in the epidermis of adrenalectomized mice.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2001;10(6):679-85.
2001: Yinghui Liu; Ellen G Duysen; AL Yaktine; Angela Au; Weiqun Wang; Diane F Birt
Dietary energy restriction inhibits ERK but not JNK or p38 activity in the epidermis of SENCAR mice.
Carcinogenesis 2001;22(4):607-12.
1999: Diane F Birt; AL Yaktine; Ellen G Duysen
Glucocorticoid mediation of dietary energy restriction inhibition of mouse skin carcinogenesis.
The Journal of nutrition 1999;129(2S Suppl):571S-574S.
1998: AL Yaktine; R Vaughn; DJ Blackwood; Ellen G Duysen; Diane F Birt
Dietary energy restriction in the SENCAR mouse: elevation of glucocorticoid hormone levels but no change in distribution of glucocorticoid receptor in epidermal cells.
Molecular carcinogenesis 1998;21(1):62-9.
1997: Diane F Birt; Parviz M Pour; D L Nagel; T Barnett; D Blackwood; Ellen G Duysen
Dietary energy restriction does not inhibit pancreatic carcinogenesis by N-nitrosobis-2-(oxopropyl)amine in the Syrian hamster.
Carcinogenesis 1997;18(11):2107-11.