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Michael Kuhar

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M O Job; G W Hubert; J Licata; Michael J Kuhar
Intra-accumbal administration of shRNAs against CART peptides cause increases in body weight and cocaine-induced locomotor activity in rats.
Burcu Balkan; Oguz Gozen; Aysegul Keser; Ersin O Koylu; Michael J Kuhar; Sakire Pogun
Region- and sex-specific changes in CART mRNA in rat hypothalamic nuclei induced by forced swim stress.
Burcu Balkan; Aysegul Keser; Michael J Kuhar; Oguz Gozen; Taner Dagci; Ersin O Koylu; Sakire Pogun
Forced swim stress elicits region-specific changes in CART expression in the stress axis and stress regulatory brain areas.

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All Publications

2012: M O Job; G W Hubert; J Licata; Michael J Kuhar
Intra-accumbal administration of shRNAs against CART peptides cause increases in body weight and cocaine-induced locomotor activity in rats.
Brain research 2012;1482():47-54.
2012: Burcu Balkan; Oguz Gozen; Aysegul Keser; Ersin O Koylu; Michael J Kuhar; Sakire Pogun
Region- and sex-specific changes in CART mRNA in rat hypothalamic nuclei induced by forced swim stress.
Brain research 2012;1479():62-71.
2012: Burcu Balkan; Aysegul Keser; Michael J Kuhar; Oguz Gozen; Taner Dagci; Ersin O Koylu; Sakire Pogun
Forced swim stress elicits region-specific changes in CART expression in the stress axis and stress regulatory brain areas.
Brain research 2012;1432():56-65.
2011: Michael J Kuhar
Collegial ethics: what, why and how.
Drug and alcohol dependence 2011;119(3):235-8.
2011: Yiming Lin; Randy A Hall; Michael J Kuhar
CART peptide stimulation of G protein-mediated signaling in differentiated PC12 cells: identification of PACAP 6-38 as a CART receptor antagonist.
Neuropeptides 2011;45(5):351-8.
2011: Syed F Ali; J L Cadet; P R Dodd; Michael J Kuhar; E S Onaivi; S Schenk; G F Koob
Understanding the Global Problem of Drug Addiction is a Challenge for IDARS Scientists.
Current neuropharmacology 2011;9(1):2-7.
2011: Mark C Moffett; Jane Song; Michael J Kuhar
CART peptide inhibits locomotor activity induced by simultaneous stimulation of D1 and D2 receptors, but not by stimulation of individual dopamine receptors.
Synapse (New York, N.Y.) 2011;65(1):1-7.
2010: Julia A Frugoli; Anne M Etgen; Michael J Kuhar
Developing and communicating responsible data management policies to trainees and colleagues.
Science and engineering ethics 2010;16(4):753-62.
2010: George A Rogge; Li-Ling Shen; Michael J Kuhar
Chromatin immunoprecipitation assays revealed CREB and serine 133 phospho-CREB binding to the CART gene proximal promoter.
Brain research 2010;1344():1-12.
2010: Glenda L Keating; Michael J Kuhar; Donald L Bliwise; David B Rye
Wake promoting effects of cocaine and amphetamine-regulated transcript (CART).
Neuropeptides 2010;44(3):241-6.
2010: Michael J Kuhar
Conversation with Michael Kuhar.
Addiction (Abingdon, England) 2010;105(4):593-600.
2010: Michael J Kuhar
Measuring levels of proteins by various technologies: can we learn more by measuring turnover?
Biochemical pharmacology 2010;79(5):665-8.
2010: George W Hubert; D F Manvich; Michael J Kuhar
Cocaine and amphetamine-regulated transcript-containing neurons in the nucleus accumbens project to the ventral pallidum in the rat and may inhibit cocaine-induced locomotion.
Neuroscience 2010;165(1):179-87.
2009: Michael J Kuhar
Blacklisting among scientists.
Synapse (New York, N.Y.) 2009;63(7):539-40.
2009: D C Jones; Anita Lakatos; G A Rogge; Michael J Kuhar
Regulation of cocaine- and amphetamine-regulated transcript mRNA expression by calcium-mediated signaling in GH3 cells.
Neuroscience 2009;160(2):339-47.
2009: Michael J Kuhar
On the use of protein turnover and half-lives.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009;34(5):1172-3.
2009: George A Rogge; Douglas C Jones; Thomas Green; Eric Nestler; Michael J Kuhar
Regulation of CART peptide expression by CREB in the rat nucleus accumbens in vivo.
Brain research 2009;1251():42-52.
2008: George Rogge; D Jones; George W Hubert; Y Lin; Michael J Kuhar
CART peptides: regulators of body weight, reward and other functions.
Nature reviews. Neuroscience 2008;9(10):747-58.
2008: Michael J Kuhar
On blacklisting in science.
Science and engineering ethics 2008;14(3):301-3.
2008: D D Francis; Michael J Kuhar
Frequency of maternal licking and grooming correlates negatively with vulnerability to cocaine and alcohol use in rats.
Pharmacology, biochemistry, and behavior 2008;90(3):497-500.
2008: F B Lima; Jessica A Henderson; Ashok P Reddy; Y Tokuyama; G W Hubert; Michael J Kuhar; Cynthia L Bethea
Unique responses of midbrain CART neurons in macaques to ovarian steroids.
Brain research 2008;1227():76-88.
2008: Jason N Jaworski; Stephen T Hansen; Michael J Kuhar; Gregory P Mark
Injection of CART (cocaine- and amphetamine-regulated transcript) peptide into the nucleus accumbens reduces cocaine self-administration in rats.
Behavioural brain research 2008;191(2):266-71.
2008: George W Hubert; Michael J Kuhar
Cocaine administration increases the fraction of CART cells in the rat nucleus accumbens that co-immunostain for c-Fos.
Neuropeptides 2008;42(3):339-43.
2008: S M Bartell; Carlos M. Isales; Clifton A Baile; Michael J Kuhar; Mark W Hamrick
CART deficiency increases body weight but does not alter bone strength.
Journal of musculoskeletal & neuronal interactions 2008;8(2):146-53.
2008: Glenda L Keating; Michael J Kuhar; David B Rye
High dose CART peptide induces abnormal EEG activity and behavioral seizures.
Neuropeptides 2008;42(2):199-204.
2008: Douglas C Jones; Michael J Kuhar
CART receptor binding in primary cell cultures of the rat nucleus accumbens.
Synapse (New York, N.Y.) 2008;62(2):122-7.
2008: Jorien M M van der Burg; Karl Bacos; Nigel I Wood; Andreas Lindqvist; Nils Wierup; Ben Woodman; Jaclyn I Wamsteeker; Ruben Smith; Tomas Deierborg; Michael J Kuhar; Gillian P Bates; Hindrik Mulder; Charlotte Erlanson-Albertsson; A Jennifer Morton; Patrik Brundin; Asa Petersén; Maria Björkqvist
Increased metabolism in the R6/2 mouse model of Huntington's disease.
Neurobiology of disease 2008;29(1):41-51.
2008: George W Hubert; Douglas C Jones; Mark C Moffett; George Rogge; Michael J Kuhar
CART peptides as modulators of dopamine and psychostimulants and interactions with the mesolimbic dopaminergic system.
Biochemical pharmacology 2008;75(1):57-62.
2007: Paul K Gong; Bruce E Blough; Lawrence E Brieaddy; Xiaodong Huang; Michael J Kuhar; Hernán A Navarro; Frank carroll
Synthesis, monoamine transporter binding, properties, and functional monoamine uptake activity of 3beta-[4-methylphenyl and 4-chlorophenyl]-2 beta-[5-(substituted phenyl)thiazol-2-yl]tropanes.
Journal of medicinal chemistry 2007;50(15):3686-95.
2007: Oguz Gozen; Burcu Balkan; Gorkem Yararbas; Ersin O Koylu; Michael J Kuhar; Sakire Pogun
Sex differences in the regulation of cocaine and amphetamine-regulated transcript expression in hypothalamic nuclei of rats by forced swim stress.
Synapse (New York, N.Y.) 2007;61(7):561-8.
2007: Anna Gunnarsdóttir; Nils Wierup; Lars-Torsten Larsson; Michael J Kuhar; Eva Ekblad
CART-peptide immunoreactivity in enteric nerves in patients with Hirschsprung's disease.
European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie 2007;17(3):184-9.
2007: Jason N Jaworski; Heather L Kimmel; Darlene A Mitrano; Ronald J Tallarida; Michael J Kuhar
Intra-VTA CART 55-102 reduces the locomotor effect of systemic cocaine in rats: an isobolographic analysis.
Neuropeptides 2007;41(2):65-72.
2007: Mark C Moffett; Aleksandra Vicentic; Marie Kozel; Paul M Plotsky; Darlene D Francis; Michael J Kuhar
Maternal separation alters drug intake patterns in adulthood in rats.
Biochemical pharmacology 2007;73(3):321-30.
2006: Frank carroll; Barbara S Fox; Michael J Kuhar; James L Howard; Gerald T Pollard; Susan Schenk
Effects of dopamine transporter selective 3-phenyltropane analogs on locomotor activity, drug discrimination, and cocaine self-administration after oral administration.
European journal of pharmacology 2006;553(1-3):149-56.
2006: George W Hubert; Michael J Kuhar
Colocalization of CART peptide with prodynorphin and dopamine D1 receptors in the rat nucleus accumbens.
Neuropeptides 2006;40(6):409-15.
2006: Ersin O Koylu; Burcu Balkan; Michael J Kuhar; Sakire Pogun
Cocaine and amphetamine regulated transcript (CART) and the stress response.
Peptides 2006;27(8):1956-69.
2006: M Imad Damaj; Jianfeng Zheng; Billy R Martin; Michael J Kuhar
Intrathecal CART (55-102) attenuates hyperlagesia and allodynia in a mouse model of neuropathic but not inflammatory pain.
Peptides 2006;27(8):2019-23.
2006: Mark C Moffett; Lisa M Stanek; Jill Harley; George Rogge; Mark Asnicar; Hansen M Hsiung; Michael J Kuhar
Studies of cocaine- and amphetamine-regulated transcript (CART) knockout mice.
Peptides 2006;27(8):2037-45.
2006: Michael J Kuhar
Should Codes of Ethics include expectations of others?
Science and engineering ethics 2006;12(3):413-4.
2006: Andrew R Joyce; Keith W Easterling; Stephen G Holtzman; Michael J Kuhar
Modeling the onset of drug dependence: a consideration of the requirement for protein synthesis.
Journal of theoretical biology 2006;240(4):531-7.
2006: Aleksandra Vicentic; D Francis; Mark C Moffett; Anita Lakatos; George Rogge; George W Hubert; Jill Harley; Michael J Kuhar
Maternal separation alters serotonergic transporter densities and serotonergic 1A receptors in rat brain.
Neuroscience 2006;140(1):355-65.
2006: Burcu Balkan; Oguz Gozen; Gorkem Yararbas; Ersin O Koylu; Serra Akinturk; Michael J Kuhar; Sakire Pogun
CART expression in limbic regions of rat brain following forced swim stress: sex differences.
Neuropeptides 2006;40(3):185-93.
2006: Mark C Moffett; Jill Harley; Darlene Francis; Sonal P Sanghani; Wilhelmina I Davis; Michael J Kuhar
Maternal separation and handling affects cocaine self-administration in both the treated pups as adults and the dams.
The Journal of pharmacology and experimental therapeutics 2006;317(3):1210-8.
2006: Richard Hunter; Douglas Jones; Aleksandra Vicentic; Gillian Hue; David Rye; Michael J Kuhar
Regulation of CART mRNA in the rat nucleus accumbens via D3 dopamine receptors.
Neuropharmacology 2006;50(7):858-64.
2006: Douglas C Jones; Michael J Kuhar
Cocaine-amphetamine-regulated transcript expression in the rat nucleus accumbens is regulated by adenylyl cyclase and the cyclic adenosine 5'-monophosphate/protein kinase a second messenger system.
The Journal of pharmacology and experimental therapeutics 2006;317(1):454-61.
2006: Nils Wierup; Maria Björkqvist; Michael J Kuhar; Hindrik Mulder; Frank Sundler
CART regulates islet hormone secretion and is expressed in the beta-cells of type 2 diabetic rats.
Diabetes 2006;55(2):305-11.
2006: Frank carroll; James L Howard; Leonard L Howell; Barbara S Fox; Michael J Kuhar
Development of the dopamine transporter selective RTI-336 as a pharmacotherapy for cocaine abuse.
The AAPS journal 2006;8(1):E196-203.
2006: Emanuele Miraglia del Giudice; N Santoro; P Fiumani; G Dominguez; Michael J Kuhar; Laura Perrone
Adolescents carrying a missense mutation in the CART gene exhibit increased anxiety and depression.
Depression and anxiety 2006;23(2):90-2.
2006: Tulin Yanik; Geraldina Dominguez; Michael J Kuhar; Emanuele M Del Giudice; Y Peng Loh
The Leu34Phe ProCART mutation leads to cocaine- and amphetamine-regulated transcript (CART) deficiency: a possible cause for obesity in humans.
Endocrinology 2006;147(1):39-43.
2005: Aleksandra Vicentic; Anita Lakatos; Michael J Kuhar
CART (cocaine- and amphetamine-regulated transcript) peptide receptors: specific binding in AtT20 cells.
European journal of pharmacology 2005;528(1-3):188-9.
2005: Scott Hemby; Wenxue Tang; E Chris Muly; Michael J Kuhar; Leonard L Howell; Deborah C Mash
Cocaine-induced alterations in nucleus accumbens ionotropic glutamate receptor subunits in human and non-human primates.
Journal of neurochemistry 2005;95(6):1785-93.
2005: Sharadsrikar Kotturi; Songchun Jiang; An-Chih Chang; Philip Abraham; Hernán A Navarro; Michael J Kuhar; Frank carroll
Synthesis and monoamine transporter binding properties of 2,3-diaryltropanes.
Journal of medicinal chemistry 2005;48(23):7437-44.
2005: Anita Lakatos; Steven Prinster; Aleksandra Vicentic; Randy A Hall; Michael J Kuhar
Cocaine- and amphetamine-regulated transcript (CART) peptide activates the extracellular signal-regulated kinase (ERK) pathway in AtT20 cells via putative G-protein coupled receptors.
Neuroscience letters 2005;384(1-2):198-202.
2005: J N Jaworski; Darlene D Francis; C L Brommer; Edward T Morgan; Michael J Kuhar
Effects of early maternal separation on ethanol intake, GABA receptors and metabolizing enzymes in adult rats.
Psychopharmacology 2005;181(1):8-15.
2005: George W Hubert; Michael J Kuhar
Colocalization of CART with substance P but not enkephalin in the rat nucleus accumbens.
Brain research 2005;1050(1-2):8-14.
2005: N Wierup; W G Richards; Anthony W Bannon; Michael J Kuhar; B Ahrén; Frank Sundler
CART knock out mice have impaired insulin secretion and glucose intolerance, altered beta cell morphology and increased body weight.
Regulatory peptides 2005;129(1-3):203-11.
2005: Richard Hunter; Aleksandra Vicentic; George Rogge; Michael J Kuhar
The effects of cocaine on CART expression in the rat nucleus accumbens: a possible role for corticosterone.
European journal of pharmacology 2005;517(1-2):45-50.
2005: Richard Hunter; Miranda M Lim; Kelly B Philpot; Larry J Young; Michael J Kuhar
Species differences in brain distribution of CART mRNA and CART peptide between prairie and meadow voles.
Brain research 2005;1048(1-2):12-23.
2005: Frank carroll; Sameer Tyagi; Bruce E Blough; Michael J Kuhar; Hernán A Navarro
Synthesis and monoamine transporter binding properties of 3alpha-(substituted phenyl)nortropane-2beta-carboxylic acid methyl esters. Norepinephrine transporter selective compounds.
Journal of medicinal chemistry 2005;48(11):3852-7.
2005: Frank carroll; Bruce E Blough; Zhe Nie; Michael J Kuhar; Leonard L Howell; Hernán A Navarro
Synthesis and monoamine transporter binding properties of 3beta-(3',4'-disubstituted phenyl)tropane-2beta-carboxylic acid methyl esters.
Journal of medicinal chemistry 2005;48(8):2767-71.
2005: Scott P Runyon; Jason P Burgess; Philip Abraham; Kathryn I Keverline-Frantz; Judith L Flippen-Anderson; Jeffrey Deschamps; Anita H Lewin; Hernán A Navarro; John W Boja; Michael J Kuhar; Frank carroll
Synthesis, structural identification, and ligand binding of tropane ring analogs of paroxetine and an unexpected aza-bicyclo[3.2.2]nonane rearrangement product.
Bioorganic & medicinal chemistry 2005;13(7):2439-49.
2005: Aleksandra Vicentic; Richard Hunter; Michael J Kuhar
Effect of corticosterone on CART peptide levels in rat blood.
Peptides 2005;26(3):531-3.
2005: Aleksandra Vicentic; Anita Lakatos; Richard Hunter; Kelly B Philpot; Geraldina Dominguez; Michael J Kuhar
CART peptide diurnal rhythm in brain and effect of fasting.
Brain research 2005;1032(1-2):111-5.
2005: Kelly B Philpot; Stephanie Dallvechia-Adams; Yoland Smith; Michael J Kuhar
A cocaine-and-amphetamine-regulated-transcript peptide projection from the lateral hypothalamus to the ventral tegmental area.
Neuroscience 2005;135(3):915-25.
2005: Michael J Kuhar; Jason N Jaworski; George W Hubert; Kelly B Philpot; Geraldina Dominguez
Cocaine- and amphetamine-regulated transcript peptides play a role in drug abuse and are potential therapeutic targets.
The AAPS journal 2005;7(1):E259-65.
2005: Douglas Osei-Hyiaman; Michael Depetrillo; Judith Harvey-White; Anthony W Bannon; Benjamin F Cravatt; Michael J Kuhar; Ken Mackie; Miklós Palkovits; George Kunos
Cocaine- and amphetamine-related transcript is involved in the orexigenic effect of endogenous anandamide.
Neuroendocrinology 2005;81(4):273-82.
2004: Frank carroll; Scott P Runyon; Philip Abraham; Hernán A Navarro; Michael J Kuhar; Gerald T Pollard; James L Howard
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
Journal of medicinal chemistry 2004;47(25):6401-9.
2004: G Dominguez; E M del Giudice; Michael J Kuhar
CART peptide levels are altered by a mutation associated with obesity at codon 34.
Molecular psychiatry 2004;9(12):1065-6.
2004: Richard Hunter; Kelly B Philpot; Aleksandra Vicentic; Geraldina Dominguez; George W Hubert; Michael J Kuhar
CART in feeding and obesity.
Trends in endocrinology and metabolism: TEM 2004;15(9):454-9.
2004: M Imad Damaj; Richard Hunter; Billy R Martin; Michael J Kuhar
Intrathecal CART (55-102) enhances the spinal analgesic actions of morphine in mice.
Brain research 2004;1024(1-2):146-9.
2004: Geraldina Dominguez; Aleksandra Vicentic; Emanuele Miraglia del Giudice; Jason N Jaworski; Richard Hunter; Michael J Kuhar
CART peptides: modulators of mesolimbic dopamine, feeding, and stress.
Annals of the New York Academy of Sciences 2004;1025():363-9.
2004: Yang-Ho Choi; Mary Anne Della-Fera; ChangLong Li; Diane L Hartzell; Dianne E Little; Michael J Kuhar; Clifton A Baile
CART peptide: central mediator of leptin-induced adipose tissue apoptosis?
Regulatory peptides 2004;121(1-3):155-62.
2004: Aleksandra Vicentic; Geraldina Dominguez; Richard Hunter; Kelly B Philpot; Mark E. Wilson; Michael J Kuhar
Cocaine- and amphetamine-regulated transcript peptide levels in blood exhibit a diurnal rhythm: regulation by glucocorticoids.
Endocrinology 2004;145(9):4119-24.
2004: Geraldina Dominguez; Michael J Kuhar
Transcriptional regulation of the CART promoter in CATH.a cells.
Brain research. Molecular brain research 2004;126(1):22-9.
2004: Genshin Kuriyama; Susumu Takekoshi; Katsuyoshi Tojo; Yoshikatsu Nakai; Michael J Kuhar; R Yoshiyuki Osamura
Cocaine- and amphetamine-regulated transcript peptide in the rat anterior pituitary gland is localized in gonadotrophs and suppresses prolactin secretion.
Endocrinology 2004;145(5):2542-50.
2004: Nils Wierup; Michael J Kuhar; Bengt-Olof Nilsson; Hindrik Mulder; Eva Ekblad; F Sundler
Cocaine- and amphetamine-regulated transcript (CART) is expressed in several islet cell types during rat development.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004;52(2):169-77.
2004: Frank carroll; Neil Pawlush; Michael J Kuhar; Gerald T Pollard; James L Howard
Synthesis, monoamine transporter binding properties, and behavioral pharmacology of a series of 3beta-(substituted phenyl)-2beta-(3'-substituted isoxazol-5-yl)tropanes.
Journal of medicinal chemistry 2004;47(2):296-302.
2003: Jason N Jaworski; Marie A Kozel; Kelly B Philpot; Michael J Kuhar
Intra-accumbal injection of CART (cocaine-amphetamine regulated transcript) peptide reduces cocaine-induced locomotor activity.
The Journal of pharmacology and experimental therapeutics 2003;307(3):1038-44.
2003: Eva Ekblad; Michael J Kuhar; Nils Wierup; F Sundler
Cocaine- and amphetamine-regulated transcript: distribution and function in rat gastrointestinal tract.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2003;15(5):545-57.
2003: Burcu Balkan; Ersin O Koylu; Sakire Pogun; Michael J Kuhar
Effects of adrenalectomy on CART expression in the rat arcuate nucleus.
Synapse (New York, N.Y.) 2003;50(1):14-9.
2003: M Imad Damaj; Billy R Martin; Michael J Kuhar
Antinociceptive effects of supraspinal rat cart (55-102) peptide in mice.
Brain research 2003;983(1-2):233-6.
2003: Michael J Kuhar; AR Joyce
Is the onset of psychoactive drug effects compatible with a protein-synthesis mechanism?
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28 Suppl 1():S94-7.
2003: Jason N Jaworski; Aleksandra Vicentic; Richard Hunter; Heather L Kimmel; Michael J Kuhar
CART peptides are modulators of mesolimbic dopamine and psychostimulants.
Life sciences 2003;73(6):741-7.
2003: Richard Hunter; Michael J Kuhar
CART peptides as targets for CNS drug development.
Current drug targets. CNS and neurological disorders 2003;2(3):201-5.
2003: Heather L Kimmel; Frank carroll; Michael J Kuhar
Withdrawal from repeated cocaine alters dopamine transporter protein turnover in the rat striatum.
The Journal of pharmacology and experimental therapeutics 2003;304(1):15-21.
2002: Bruce E Blough; Kathryn I Keverline; Zhe Nie; Hernán A Navarro; Michael J Kuhar; Frank carroll
Synthesis and transporter binding properties of 3beta-[4'-(phenylalkyl, -phenylalkenyl, and -phenylalkynyl)phenyl]tropane-2beta-carboxylic acid methyl esters: evidence of a remote phenyl binding domain on the dopamine transporter.
Journal of medicinal chemistry 2002;45(18):4029-37.
2002: Anita Lakatos; Geraldina Dominguez; Michael J Kuhar
CART promoter CRE site binds phosphorylated CREB.
Brain research. Molecular brain research 2002;104(1):81-5.
2002: Stephanie Dallvechia-Adams; Michael J Kuhar; Yoland Smith
Cocaine- and amphetamine-regulated transcript peptide projections in the ventral midbrain: colocalization with gamma-aminobutyric acid, melanin-concentrating hormone, dynorphin, and synaptic interactions with dopamine neurons.
The Journal of comparative neurology 2002;448(4):360-72.
2002: Geraldina Dominguez; Anita Lakatos; Michael J Kuhar
Characterization of the cocaine- and amphetamine-regulated transcript (CART) peptide gene promoter and its activation by a cyclic AMP-dependent signaling pathway in GH3 cells.
Journal of neurochemistry 2002;80(5):885-93.
2002: Heather L Kimmel; L Thim; Michael J Kuhar
Activity of various CART peptides in changing locomotor activity in the rat.
Neuropeptides 2002;36(1):9-12.
2002: Michael J Kuhar; S Adams; Geraldina Dominguez; Jason N Jaworski; B Balkan
CART peptides.
Neuropeptides 2002;36(1):1-8.
2002: Michael J Kuhar
Social rank and vulnerability to drug abuse.
Nature neuroscience 2002;5(2):88-90.
2001: Heather L Kimmel; Frank carroll; Michael J Kuhar
Locomotor stimulant effects of novel phenyltropanes in the mouse.
Drug and alcohol dependence 2001;65(1):25-36.
2001: Burcu Balkan; Ersin O Koylu; Michael J Kuhar; Sakire Pogun
The effect of adrenalectomy on cocaine and amphetamine-regulated transcript (CART) expression in the hypothalamic nuclei of the rat.
Brain research 2001;917(1):15-20.
2001: Michael J Kuhar; AR Joyce
Slow onset of CNS drugs: can changes in protein concentration account for the delay?
Trends in pharmacological sciences 2001;22(9):450-6.
2001: Hernán A Navarro; H Xu; D Zhong; Bruce E Blough; W P Ross; Michael J Kuhar; Frank carroll
[(125)I]3beta-(4-ethyl-3-iodophenyl)nortropane-2beta-carboxylic acid methyl ester ([(125)I]EINT): a potent and selective radioligand for the brain serotonin transporter.
Synapse (New York, N.Y.) 2001;41(3):241-7.
2001: Qun Wu; Maarten E A Reith; Michael J Kuhar; Frank carroll; Paul Garris
Preferential increases in nucleus accumbens dopamine after systemic cocaine administration are caused by unique characteristics of dopamine neurotransmission.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(16):6338-47.
2001: Michael J Kuhar; Frank carroll; Narine Bharat; Donald W Landry
Anticocaine catalytic antibodies have no affinity for RTI compounds: implications for treatment.
Synapse (New York, N.Y.) 2001;41(2):176-8.
2001: Heather L Kimmel; AR Joyce; Frank carroll; Michael J Kuhar
Dopamine D1 and D2 receptors influence dopamine transporter synthesis and degradation in the rat.
The Journal of pharmacology and experimental therapeutics 2001;298(1):129-40.
2001: Susan Aja; Gary J Schwartz; Michael J Kuhar; Timothy H Moran
Intracerebroventricular CART peptide reduces rat ingestive behavior and alters licking microstructure.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;280(6):R1613-9.
2001: Stephanie Dallvechia-Adams; Yoland Smith; Michael J Kuhar
CART peptide-immunoreactive projection from the nucleus accumbens targets substantia nigra pars reticulata neurons in the rat.
The Journal of comparative neurology 2001;434(1):29-39.
2001: Michael J Kuhar
In vitro autoradiography.
Current protocols in pharmacology / editorial board, S.J. Enna (editor-in-chief) ... [et al.] 2001;Chapter 8():Unit 8.1.
2001: Michael J Kuhar; A Joyce; G Dominguez
Genes in drug abuse.
Drug and alcohol dependence 2001;62(3):157-62.
2001: Heather L Kimmel; Aleksandra Vicentic; Michael J Kuhar
Neurotransmitter transporters synthesis and degradation rates.
Life sciences 2001;68(19-20):2181-5.
2001: Heather L Kimmel; Frank carroll; Michael J Kuhar
RTI-76, an irreversible inhibitor of dopamine transporter binding, increases locomotor activity in the rat at high doses.
Brain research 2001;897(1-2):157-63.
2001: CF Elias; Charlotte E Lee; JF Kelly; Rexford S Ahima; Michael J Kuhar; Clifford B Saper; Joel K Elmquist
Characterization of CART neurons in the rat and human hypothalamus.
The Journal of comparative neurology 2001;432(1):1-19.
2001: Sarah A Stanley; Caroline J Small; Kevin G Murphy; E Rayes; Caroline R Abbott; Leighton J Seal; D G A Morgan; D Sunter; Catherine L Dakin; Min-Seon Kim; R Hunter; Michael J Kuhar; Mohammad A Ghatei; Stephen R Bloom
Actions of cocaine- and amphetamine-regulated transcript (CART) peptide on regulation of appetite and hypothalamo-pituitary axes in vitro and in vivo in male rats.
Brain research 2001;893(1-2):186-94.
2000: Csaba Fekete; Emese Mihály; LG Luo; J Kelly; Jes Thorn Clausen; Q Mao; William M Rand; L G Moss; Michael J Kuhar; Charles H Emerson; IM Jackson; Ronald M Lechan
Association of cocaine- and amphetamine-regulated transcript-immunoreactive elements with thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and its role in the regulation of the hypothalamic-pituitary-thyroid axis during fasting.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(24):9224-34.
2000: Jeanette E Johansen; C Broberger; Catharina Lavebratt; C Johansson; Michael J Kuhar; Tomas Hökfelt; Martin Schalling
Hypothalamic CART and serum leptin levels are reduced in the anorectic (anx/anx) mouse.
Brain research. Molecular brain research 2000;84(1-2):97-105.
2000: Bruce E Blough; C R Holmquist; Philip Abraham; Michael J Kuhar; Frank carroll
3alpha-(4-Substituted phenyl)nortropane-2beta-carboxylic acid methyl esters show selective binding at the norepinephrine transporter.
Bioorganic & medicinal chemistry letters 2000;10(21):2445-7.
2000: Lijuan C Wang; Janet L Berfield; Michael J Kuhar; F I Carroll; Maarten E A Reith
RTI-76, an isothiocyanate derivative of a phenyltropane cocaine analog, as a tool for irreversibly inactivating dopamine transporter function in vitro.
Naunyn-Schmiedeberg's archives of pharmacology 2000;362(3):238-47.
2000: Kevin G Murphy; Caroline R Abbott; M Mahmoudi; R Hunter; James V Gardiner; M Rossi; Sarah A Stanley; Mohammad A Ghatei; Michael J Kuhar; Stephen R Bloom
Quantification and synthesis of cocaine- and amphetamine-regulated transcript peptide (79-102)-like immunoreactivity and mRNA in rat tissues.
The Journal of endocrinology 2000;166(3):659-68.
2000: Heather L Kimmel; W Gong; SD Vechia; Richard Hunter; Michael J Kuhar
Intra-ventral tegmental area injection of rat cocaine and amphetamine-regulated transcript peptide 55-102 induces locomotor activity and promotes conditioned place preference.
The Journal of pharmacology and experimental therapeutics 2000;294(2):784-92.
2000: Ersin O Koylu; Eduardo Weruaga; Burcu Balkan; José R Alonso; Michael J Kuhar; Sakire Pogun
Co-localization of cart peptide immunoreactivity and nitric oxide synthase activity in rat hypothalamus.
Brain research 2000;868(2):352-7.
2000: Michael J Kuhar; L D Adams; Richard Hunter; SD Vechia; Yoland Smith
CART peptides.
Regulatory peptides 2000;89(1-3):1-6.
2000: Heather L Kimmel; Frank carroll; Michael J Kuhar
Dopamine transporter synthesis and degradation rate in rat striatum and nucleus accumbens using RTI-76.
Neuropharmacology 2000;39(4):578-85.
2000: Leonard L Howell; Paul W Czoty; Michael J Kuhar; F I Carrol
Comparative behavioral pharmacology of cocaine and the selective dopamine uptake inhibitor RTI-113 in the squirrel monkey.
The Journal of pharmacology and experimental therapeutics 2000;292(2):521-9.
2000: SE Dall Vechia; PD Lambert; P C Couceyro; Michael J Kuhar; Yoland Smith
CART peptide immunoreactivity in the hypothalamus and pituitary in monkeys: analysis of ultrastructural features and synaptic connections in the paraventricular nucleus.
The Journal of comparative neurology 2000;416(3):291-308.
1999: L D Adams; W Gong; SD Vechia; Richard Hunter; Michael J Kuhar
CART: from gene to function.
Brain research 1999;848(1-2):137-40.
1999: S Javanmard; Howard M Deutsch; David M Collard; Michael J Kuhar; Margaret M Schweri
Synthesis and pharmacology of site-specific cocaine abuse treatment agents: 2-substituted-6-amino-5-phenylbicyclo[2.2.2]octanes.
Journal of medicinal chemistry 1999;42(23):4836-43.
1999: Christian Broberger; Kristina Holmberg; Michael J Kuhar; Tomas Hökfelt
Cocaine- and amphetamine-regulated transcript in the rat vagus nerve: A putative mediator of cholecystokinin-induced satiety.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(23):13506-11.
1999: Christian Broberger; T J Visser; Michael J Kuhar; Tomas Hökfelt
Neuropeptide Y innervation and neuropeptide-Y-Y1-receptor-expressing neurons in the paraventricular hypothalamic nucleus of the mouse.
Neuroendocrinology 1999;70(5):295-305.
1999: A Vicentic; George Battaglia; F I Carroll; Michael J Kuhar
Serotonin transporter production and degradation rates: studies with RTI-76.
Brain research 1999;841(1-2):1-10.
1999: Michael J Kuhar; L L Yoho
CART peptide analysis by Western blotting.
Synapse (New York, N.Y.) 1999;33(3):163-71.
1999: Michael J Kuhar; KM McGirr; Richard Hunter; PD Lambert; B E Garrett; Frank carroll
Studies of selected phenyltropanes at monoamine transporters.
Drug and alcohol dependence 1999;56(1):9-15.
1999: PD Lambert; KM McGirr; Timothy D Ely; Clinton D Kilts; Michael J Kuhar
Chronic lithium treatment decreases neuronal activity in the nucleus accumbens and cingulate cortex of the rat.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1999;21(2):229-37.
1999: Frank carroll; Leonard L Howell; Michael J Kuhar
Pharmacotherapies for treatment of cocaine abuse: preclinical aspects.
Journal of medicinal chemistry 1999;42(15):2721-36.
1999: M Garzón; RA Vaughan; George R. Uhl; Michael J Kuhar; Virginia M Pickel
Cholinergic axon terminals in the ventral tegmental area target a subpopulation of neurons expressing low levels of the dopamine transporter.
The Journal of comparative neurology 1999;410(2):197-210.
1999: Michael J Kuhar; SE Dall Vechia
CART peptides: novel addiction- and feeding-related neuropeptides.
Trends in neurosciences 1999;22(7):316-20.
1999: Yoland Smith; Jeremiah Kieval; PR Couceyro; Michael J Kuhar
CART peptide-immunoreactive neurones in the nucleus accumbens in monkeys: ultrastructural analysis, colocalization studies, and synaptic interactions with dopaminergic afferents.
The Journal of comparative neurology 1999;407(4):491-511.
1999: EO Koylu; Yoland Smith; PR Couceyro; Michael J Kuhar
CART peptides colocalize with tyrosine hydroxylase neurons in rat locus coeruleus.
Synapse (New York, N.Y.) 1999;31(4):309-11.
1999: Yu-Shin Ding; Patricia E Molina; Joanna S Fowler; Jean Logan; Nora D Volkow; Michael J Kuhar; F I Carroll
Comparative studies of epibatidine derivatives [18F]NFEP and [18F]N-methyl-NFEP: kinetics, nicotine effect, and toxicity.
Nuclear medicine and biology 1999;26(1):139-48.
1998: S Jiang; A C Chang; Philip Abraham; Michael J Kuhar; Frank carroll
Synthesis and transporter binding properties of (R)-2 beta, 3 beta- and (R)-2 alpha, 3 alpha-diaryltropanes.
Bioorganic & medicinal chemistry letters 1998;8(24):3689-92.
1998: CF Elias; C Lee; J Kelly; Carl J Aschkenasi; Rexford S Ahima; P R Couceyro; Michael J Kuhar; Clifford B Saper; Joel K Elmquist
Leptin activates hypothalamic CART neurons projecting to the spinal cord.
Neuron 1998;21(6):1375-85.
1998: SI Dworkin; P Lambert; Glen M Sizemore; F I Carroll; Michael J Kuhar
RTI-113 administration reduces cocaine self-administration at high occupancy of dopamine transporter.
Synapse (New York, N.Y.) 1998;30(1):49-55.
1998: J W Boja; Frank carroll; R A Vaughan; Theresa A Kopajtic; Michael J Kuhar
Multiple binding sites for [125I]RTI-121 and other cocaine analogs in rat frontal cerebral cortex.
Synapse (New York, N.Y.) 1998;30(1):9-17.
1998: PR Couceyro; Maryse Paquet; EO Koylu; Michael J Kuhar; Yoland Smith
Cocaine- and amphetamine-regulated transcript (CART) peptide immunoreactivity in myenteric plexus neurons of the rat ileum and co-localization with choline acetyltransferase.
Synapse (New York, N.Y.) 1998;30(1):1-8.
1998: PD Lambert; PR Couceyro; KM McGirr; SE Dall Vechia; Yoland Smith; Michael J Kuhar
CART peptides in the central control of feeding and interactions with neuropeptide Y.
Synapse (New York, N.Y.) 1998;29(4):293-8.
1998: EO Koylu; PR Couceyro; PD Lambert; Michael J Kuhar
Cocaine- and amphetamine-regulated transcript peptide immunohistochemical localization in the rat brain.
The Journal of comparative neurology 1998;391(1):115-32.
1998: A M Persico; Stephen G Reich; Jack E Henningfield; Michael J Kuhar; George R. Uhl
Parkinsonian patients report blunted subjective effects of methylphenidate.
Experimental and clinical psychopharmacology 1998;6(1):54-63.
1998: K I Keverline-Frantz; John W Boja; Michael J Kuhar; Philip Abraham; Jason P Burgess; Anita H Lewin; Frank carroll
Synthesis and ligand binding of tropane ring analogues of paroxetine.
Journal of medicinal chemistry 1998;41(2):247-57.
1998: Michael J Kuhar
Recent biochemical studies of the dopamine transporter--a CNS drug target.
Life sciences 1998;62(17-18):1573-5.
1998: Roxanne A Vaughan; Robin Huff; George R. Uhl; Michael J Kuhar
Phosphorylation of dopamine transporters and rapid adaptation to cocaine.
Advances in pharmacology (San Diego, Calif.) 1998;42():1042-5.
1998: Dean F Wong; George A Ricaurte; Gerhard Gründer; Richard E Rothman; Sakkubai Naidu; Harvey S Singer; James C Harris; Fuji Yokoi; Victor L Villemagne; Sally Szymanski; Albert Gjedde; Michael J Kuhar
Dopamine transporter changes in neuropsychiatric disorders.
Advances in pharmacology (San Diego, Calif.) 1998;42():219-23.
1998: Michael J Kuhar; R Vaughan; George R. Uhl; C Cerruti; R Revay; Curt R Freed; M Nirenburg; V Pickel
Localization of dopamine transporter protein by microscopic histochemistry.
Advances in pharmacology (San Diego, Calif.) 1998;42():168-70.
1997: B E Blough; Philip Abraham; A C Mills; Anita H Lewin; John W Boja; U Scheffel; Michael J Kuhar; Frank carroll
3 Beta-(4-ethyl-3-iodophenyl)nortropane-2 beta-carboxylic acid methyl ester as a high-affinity selective ligand for the serotonin transporter.
Journal of medicinal chemistry 1997;40(24):3861-4.
1997: Patricia E Molina; Yu-Shin Ding; F I Carroll; F Liang; Nora D Volkow; Naomi Pappas; Michael J Kuhar; N Abumrad; S John Gatley; Joanna S Fowler
Fluoro-norchloroepibatidine: preclinical assessment of acute toxicity.
Nuclear medicine and biology 1997;24(8):743-7.
1997: EO Koylu; PR Couceyro; PD Lambert; N C Ling; E B DeSouza; Michael J Kuhar
Immunohistochemical localization of novel CART peptides in rat hypothalamus, pituitary and adrenal gland.
Journal of neuroendocrinology 1997;9(11):823-33.
1997: MJ Nirenberg; June Chan; A Pohorille; RA Vaughan; George R. Uhl; Michael J Kuhar; Virginia M Pickel
The dopamine transporter: comparative ultrastructure of dopaminergic axons in limbic and motor compartments of the nucleus accumbens.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(18):6899-907.
1997: Yoland Smith; EO Koylu; PR Couceyro; Michael J Kuhar
Ultrastructural localization of CART (cocaine- and amphetamine-regulated transcript) peptides in the nucleus accumbens of monkeys.
Synapse (New York, N.Y.) 1997;27(1):90-4.
1997: PR Couceyro; M Shoaib; M McCoy; S R Goldberg; Michael J Kuhar
Cocaine self-administration alters brain NADH dehydrogenase mRNA levels.
Neuroreport 1997;8(11):2437-41.
1997: F Liang; H A Navarro; Philip Abraham; P Kotian; Y S Ding; Joanna S Fowler; Nora D Volkow; Michael J Kuhar; Frank carroll
Synthesis and nicotinic acetylcholine receptor binding properties of exo-2-(2'-fluoro-5'-pyridinyl)-7-azabicyclo-[2.2.1]heptane: a new positron emission tomography ligand for nicotinic receptors.
Journal of medicinal chemistry 1997;40(15):2293-5.
1997: MJ Nirenberg; June Chan; RA Vaughan; George R. Uhl; Michael J Kuhar; Virginia M Pickel
Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(14):5255-62.
1997: Roxanne A Vaughan; Robin Huff; George R. Uhl; Michael J Kuhar
Protein kinase C-mediated phosphorylation and functional regulation of dopamine transporters in striatal synaptosomes.
The Journal of biological chemistry 1997;272(24):15541-6.
1997: MJ Nirenberg; June Chan; RA Vaughan; George R. Uhl; Michael J Kuhar; Virginia M Pickel
Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(11):4037-44.
1997: PR Couceyro; EO Koylu; Michael J Kuhar
Further studies on the anatomical distribution of CART by in situ hybridization.
Journal of chemical neuroanatomy 1997;12(4):229-41.
1997: A C Chang; Jason P Burgess; Wayne Mascarella; Philip Abraham; Michael J Kuhar; Frank carroll
Synthesis and transporter binding properties of 2,3-diphenyltropane stereoisomers. Comparison to 3beta-phenyltropane-2beta-carboxylic acid esters.
Journal of medicinal chemistry 1997;40(8):1247-51.
1997: Y Zhan; A M Saindane; Ursula Scheffel; F I Carroll; C R Holmquist; J A Kepler; G F Taylor; Michael J Kuhar
RTI-352: a 3 alpha analogue of RTI-55 as an in vivo dopamine transporter binding ligand.
Synapse (New York, N.Y.) 1997;25(4):389-92.
1997: Ursula Scheffel; John R Lever; P Abraham; K R Parham; William B Mathews; Theresa A Kopajtic; F I Carroll; Michael J Kuhar
N-substituted phenyltropanes as in vivo binding ligands for rapid imaging studies of the dopamine transporter.
Synapse (New York, N.Y.) 1997;25(4):345-9.
1997: Dean F Wong; Godfrey D Pearlson; Larry E Tune; L T Young; Carolyn Meltzer; Robert F Dannals; Hayden T Ravert; J Reith; Michael J Kuhar; Albert Gjedde
Quantification of neuroreceptors in the living human brain: IV. Effect of aging and elevations of D2-like receptors in schizophrenia and bipolar illness.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1997;17(3):331-42.
1997: Robin Huff; Roxanne A Vaughan; Michael J Kuhar; George R. Uhl
Phorbol esters increase dopamine transporter phosphorylation and decrease transport Vmax.
Journal of neurochemistry 1997;68(1):225-32.
1996: W J Houlihan; J W Boja; V A Parrino; Theresa A Kopajtic; Michael J Kuhar
Halogenated mazindol analogs as potential inhibitors of the cocaine binding site at the dopamine transporter.
Journal of medicinal chemistry 1996;39(25):4935-41.
1996: Yu-Shin Ding; S John Gatley; Joanna S Fowler; Nora D Volkow; D Aggarwal; Jean Logan; Stephen L Dewey; F Liang; F I Carroll; Michael J Kuhar
Mapping nicotinic acetylcholine receptors with PET.
Synapse (New York, N.Y.) 1996;24(4):403-7.
1996: C R Holmquist; K I Keverline-Frantz; Philip Abraham; J W Boja; Michael J Kuhar; Frank carroll
3 alpha-(4'-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters: novel ligands with high affinity and selectivity at the dopamine transporter.
Journal of medicinal chemistry 1996;39(21):4139-41.
1996: A E Fleckenstein; S Pögün; Frank carroll; Michael J Kuhar
Recovery of dopamine transporter binding and function after intrastriatal administration of the irreversible inhibitor RTI-76 [3 beta-(3p-chlorophenyl) tropan-2 beta-carboxylic acid p-isothiocyanatophenylethyl ester hydrochloride].
The Journal of pharmacology and experimental therapeutics 1996;279(1):200-6.
1996: B E Blough; Philip Abraham; Anita H Lewin; Michael J Kuhar; J W Boja; Frank carroll
Synthesis and transporter binding properties of 3 beta-(4'-alkyl-, 4'-alkenyl-, and 4'-alkynylphenyl)nortropane-2 beta-carboxylic acid methyl esters: serotonin transporter selective analogs.
Journal of medicinal chemistry 1996;39(20):4027-35.
1996: A E Fleckenstein; Theresa A Kopajtic; J W Boja; Frank carroll; Michael J Kuhar
Highly potent cocaine analogs cause long-lasting increases in locomotor activity.
European journal of pharmacology 1996;311(2-3):109-14.
1996: Roxanne A Vaughan; Michael J Kuhar
Dopamine transporter ligand binding domains. Structural and functional properties revealed by limited proteolysis.
The Journal of biological chemistry 1996;271(35):21672-80.
1996: P Kotian; Wayne Mascarella; Philip Abraham; Anita H Lewin; J W Boja; Michael J Kuhar; Frank carroll
Synthesis, ligand binding, and quantitative structure-activity relationship study of 3 beta-(4'-substituted phenyl)-2 beta-heterocyclic tropanes: evidence for an electrostatic interaction at the 2 beta-position.
Journal of medicinal chemistry 1996;39(14):2753-63.
1996: Michael J Kuhar; N S Pilotte
Neurochemical changes in cocaine withdrawal.
Trends in pharmacological sciences 1996;17(7):260-4.
1996: Ursula Scheffel; C Steinert; Sang Eun Kim; Michael D Ehlers; J W Boja; Michael J Kuhar
Effect of dopaminergic drugs on the in vivo binding of [3H]WIN 35,428 to central dopamine transporters.
Synapse (New York, N.Y.) 1996;23(2):61-9.
1996: Dean F Wong; James C Harris; Sakkubai Naidu; Fuji Yokoi; S Marenco; Robert F Dannals; Hayden T Ravert; Myron Yaster; A Evans; Olivier Rousset; R Nick Bryan; Albert Gjedde; Michael J Kuhar; George R Breese
Dopamine transporters are markedly reduced in Lesch-Nyhan disease in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(11):5539-43.
1996: Roxanne A Vaughan; V L Brown; Michael T McCoy; Michael J Kuhar
Species- and brain region-specific dopamine transporters: immunological and glycosylation characteristics.
Journal of neurochemistry 1996;66(5):2146-52.
1996: Susan P Hume; Sajinder K Luthra; D J Brown; Jolanta Opacka-Juffry; Safiye Osman; S Ashworth; R Myers; Frank Brady; F I Carroll; Michael J Kuhar; David J Brooks
Evaluation of [11C]RTI-121 as a selective radioligand for PET studies of the dopamine transporter.
Nuclear medicine and biology 1996;23(3):377-84.
1996: John R Lever; Ursula Scheffel; M Stathis; Herbert H Seltzman; C D Wyrick; Philip Abraham; K Parham; Brian Thomas; J W Boja; Michael J Kuhar; Frank carroll
Synthesis and in vivo studies of a selective ligand for the dopamine transporter: 3 beta-(4-[125I]iodophenyl) tropan-2 beta-carboxylic acid isopropyl ester ([125I]RTI-121).
Nuclear medicine and biology 1996;23(3):277-84.
1996: RS Revay; R Vaughan; S Grant; Michael J Kuhar
Dopamine transporter immunohistochemistry in median eminence, amygdala, and other areas of the rat brain.
Synapse (New York, N.Y.) 1996;22(2):93-9.
1996: S John Gatley; Nora D Volkow; R Chen; Joanna S Fowler; F I Carroll; Michael J Kuhar
Displacement of RTI-55 from the dopamine transporter by cocaine.
European journal of pharmacology 1996;296(2):145-51.
1996: MJ Nirenberg; RA Vaughan; George R. Uhl; Michael J Kuhar; Virginia M Pickel
The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(2):436-47.
1996: N S Pilotte; Lawrence G Sharpe; S D Rountree; Michael J Kuhar
Cocaine withdrawal reduces dopamine transporter binding in the shell of the nucleus accumbens.
Synapse (New York, N.Y.) 1996;22(1):87-92.
1995: Ursula Scheffel; G F Taylor; J A Kepler; Frank carroll; Michael J Kuhar
In vivo labeling of neuronal nicotinic acetylcholine receptors with radiolabeled isomers of norchloroepibatidine.
Neuroreport 1995;6(18):2483-8.
1995: Frank carroll; U Scheffel; Robert F Dannals; J W Boja; Michael J Kuhar
Development of imaging agents for the dopamine transporter.
Medicinal research reviews 1995;15(5):419-44.
1995: P Kotian; Philip Abraham; Anita H Lewin; Wayne Mascarella; J W Boja; Michael J Kuhar; Frank carroll
Synthesis and ligand binding study of 3 beta-(4'-substituted phenyl)-2 beta-(heterocyclic)tropanes.
Journal of medicinal chemistry 1995;38(18):3451-3.
1995: Curt R Freed; RS Revay; Roxanne A Vaughan; E Kriek; S Grant; George R. Uhl; Michael J Kuhar
Dopamine transporter immunoreactivity in rat brain.
The Journal of comparative neurology 1995;359(2):340-9.
1995: M Stathis; Ursula Scheffel; SZ Lever; J W Boja; Frank carroll; Michael J Kuhar
Rate of binding of various inhibitors at the dopamine transporter in vivo.
Psychopharmacology 1995;119(4):376-84.
1995: Frank carroll; P Kotian; A Dehghani; J L Gray; M A Kuzemko; K A Parham; Philip Abraham; Anita H Lewin; J W Boja; Michael J Kuhar
Cocaine and 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid ester and amide analogues. New high-affinity and selective compounds for the dopamine transporter.
Journal of medicinal chemistry 1995;38(2):379-88.
1994: A P Patel; C Cerruti; Roxanne A Vaughan; Michael J Kuhar
Developmentally regulated glycosylation of dopamine transporter.
Brain research. Developmental brain research 1994;83(1):53-8.
1994: S Pögün; Michael J Kuhar
Regulation of neurotransmitter reuptake by nitric oxide.
Annals of the New York Academy of Sciences 1994;738():305-15.
1994: Frank carroll; Wayne Mascarella; M A Kuzemko; Y Gao; Philip Abraham; Anita H Lewin; J W Boja; Michael J Kuhar
Synthesis, ligand binding, and QSAR (CoMFA and classical) study of 3 beta-(3'-substituted phenyl)-, 3 beta-(4'-substituted phenyl)-, and 3 beta-(3',4'-disubstituted phenyl)tropane-2 beta-carboxylic acid methyl esters.
Journal of medicinal chemistry 1994;37(18):2865-73.
1994: S Pogun; Valina Dawson; Michael J Kuhar
Nitric oxide inhibits 3H-glutamate transport in synaptosomes.
Synapse (New York, N.Y.) 1994;18(1):21-6.
1994: N S Pilotte; Lawrence G Sharpe; Michael J Kuhar
Withdrawal of repeated intravenous infusions of cocaine persistently reduces binding to dopamine transporters in the nucleus accumbens of Lewis rats.
The Journal of pharmacology and experimental therapeutics 1994;269(3):963-9.
1994: J W Boja; Michael J Kuhar; Theresa A Kopajtic; Emily Boja; Philip Abraham; Anita H Lewin; Frank carroll
Secondary amine analogues of 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid esters and N-norcocaine exhibit enhanced affinity for serotonin and norepinephrine transporters.
Journal of medicinal chemistry 1994;37(8):1220-3.
1994: Ursula Scheffel; S Kim; E J Cline; Michael J Kuhar
Occupancy of the serotonin transporter by fluoxetine, paroxetine, and sertraline: in vivo studies with [125I]RTI-55.
Synapse (New York, N.Y.) 1994;16(4):263-8.
1994: S Pogun; Michael H Baumann; Michael J Kuhar
Nitric oxide inhibits [3H]dopamine uptake.
Brain research 1994;641(1):83-91.
1994: C Cerruti; N S Pilotte; George R. Uhl; Michael J Kuhar
Reduction in dopamine transporter mRNA after cessation of repeated cocaine administration.
Brain research. Molecular brain research 1994;22(1-4):132-8.
1994: U Scheffel; Robert F Dannals; M Suehiro; George A Ricaurte; Frank carroll; Michael J Kuhar; Henry N Wagner
Development of PET/SPECT ligands for the serotonin transporter.
NIDA research monograph 1994;138():111-30.
1993: Frank carroll; J L Gray; Philip Abraham; M A Kuzemko; Anita H Lewin; J W Boja; Michael J Kuhar
3-Aryl-2-(3'-substituted-1',2',4'-oxadiazol-5'-yl)tropane analogues of cocaine: affinities at the cocaine binding site at the dopamine, serotonin, and norepinephrine transporters.
Journal of medicinal chemistry 1993;36(20):2886-90.
1993: A Brouard; D Pelaprat; J W Boja; F I Carroll; M Vial; Michael J Kuhar; W Rostene
Potent cocaine analogs inhibit [3H]dopamine uptake in rat mesencephalic cells in primary cultures: pharmacological selectivity of embryonic cocaine sites.
Brain research. Developmental brain research 1993;75(1):13-7.
1993: A Patel; George R. Uhl; Michael J Kuhar
Species differences in dopamine transporters: postmortem changes and glycosylation differences.
Journal of neurochemistry 1993;61(2):496-500.
1993: Roxanne A Vaughan; George R. Uhl; Michael J Kuhar
Recognition of dopamine transporters by antipeptide antibodies.
Molecular and cellular neurosciences 1993;4(2):209-15.
1993: C Cerruti; D M Walther; Michael J Kuhar; George R. Uhl
Dopamine transporter mRNA expression is intense in rat midbrain neurons and modest outside midbrain.
Brain research. Molecular brain research 1993;18(1-2):181-6.
1993: Frank carroll; Anita H Lewin; Michael J Kuhar; J W Boja
Cocaine receptor: a structure-activity relationship study.
NIDA research monograph 1993;134():229-37.
1993: Susan Amara; Michael J Kuhar
Neurotransmitter transporters: recent progress.
Annual review of neuroscience 1993;16():73-93.
1993: M C Ritz; Michael J Kuhar
Psychostimulant drugs and a dopamine hypothesis regarding addiction: update on recent research.
Biochemical Society symposium 1993;59():51-64.
1992: J W Boja; R M McNeill; Anita H Lewin; Philip Abraham; Frank carroll; Michael J Kuhar
Selective dopamine transporter inhibition by cocaine analogs.
Neuroreport 1992;3(11):984-6.
1992: Ursula Scheffel; Robert F Dannals; Dean F Wong; Fuji Yokoi; Frank carroll; Michael J Kuhar
Dopamine transporter imaging with novel, selective cocaine analogs.
Neuroreport 1992;3(11):969-72.
1992: E J Cline; Ursula Scheffel; J W Boja; W M Mitchell; Frank carroll; Philip Abraham; Anita H Lewin; Michael J Kuhar
In vivo binding of [125I]RTI-55 to dopamine transporters: pharmacology and regional distribution with autoradiography.
Synapse (New York, N.Y.) 1992;12(1):37-46.
1992: J W Boja; W M Mitchell; A Patel; Theresa A Kopajtic; Frank carroll; Anita H Lewin; Philip Abraham; Michael J Kuhar
High-affinity binding of [125I]RTI-55 to dopamine and serotonin transporters in rat brain.
Synapse (New York, N.Y.) 1992;12(1):27-36.
1992: W Rostène; J W Boja; D Scherman; F I Carroll; Michael J Kuhar
Dopamine transport: pharmacological distinction between the synaptic membrane and the vesicular transporter in rat striatum.
European journal of pharmacology 1992;218(1):175-7.
1992: R Lew; A Patel; Roxanne A Vaughan; A Wilson; Michael J Kuhar
Microheterogeneity of dopamine transporters in rat striatum and nucleus accumbens.
Brain research 1992;584(1-2):266-71.
1992: J W Boja; E J Cline; Frank carroll; Anita H Lewin; A Philip; Robert F Dannals; Dean F Wong; Ursula Scheffel; Michael J Kuhar
High potency cocaine analogs: neurochemical, imaging, and behavioral studies.
Annals of the New York Academy of Sciences 1992;654():282-91.
1992: Frank carroll; Philip Abraham; Anita H Lewin; K A Parham; J W Boja; Michael J Kuhar
Isopropyl and phenyl esters of 3 beta-(4-substituted phenyl)tropan-2 beta-carboxylic acids. Potent and selective compounds for the dopamine transporter.
Journal of medicinal chemistry 1992;35(13):2497-500.
1992: Ursula Scheffel; Robert F Dannals; E J Cline; George A Ricaurte; Frank carroll; Philip Abraham; Anita H Lewin; Michael J Kuhar
[123/125I]RTI-55, an in vivo label for the serotonin transporter.
Synapse (New York, N.Y.) 1992;11(2):134-9.
1992: Frank carroll; Y Gao; Philip Abraham; Anita H Lewin; R Lew; A Patel; J W Boja; Michael J Kuhar
Probes for the cocaine receptor. Potentially irreversible ligands for the dopamine transporter.
Journal of medicinal chemistry 1992;35(10):1813-7.
1992: A Patel; J W Boja; John R Lever; R Lew; R Simantov; Frank carroll; Anita H Lewin; A Philip; Y Gao; Michael J Kuhar
A cocaine analog and a GBR analog label the same protein in rat striatal membranes.
Brain research 1992;576(1):173-4.
1992: Frank carroll; Anita H Lewin; J W Boja; Michael J Kuhar
Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter.
Journal of medicinal chemistry 1992;35(6):969-81.
1992: E J Cline; Ursula Scheffel; J W Boja; Frank carroll; Jonathan L Katz; Michael J Kuhar
Behavioral effects of novel cocaine analogs: a comparison with in vivo receptor binding potency.
The Journal of pharmacology and experimental therapeutics 1992;260(3):1174-9.
1992: J W Boja; L Markham; A Patel; George R. Uhl; Michael J Kuhar
Expression of a single dopamine transporter cDNA can confer two cocaine binding sites.
Neuroreport 1992;3(3):247-8.
1992: ELIAS SHAYA; Ursula Scheffel; Robert F Dannals; George A Ricaurte; Frank carroll; Henry N Wagner; Michael J Kuhar; Dean F Wong
In vivo imaging of dopamine reuptake sites in the primate brain using single photon emission computed tomography (SPECT) and iodine-123 labeled RTI-55.
Synapse (New York, N.Y.) 1992;10(2):169-72.
1992: Philip Abraham; J B Pitner; Anita H Lewin; J W Boja; Michael J Kuhar; Frank carroll
N-modified analogues of cocaine: synthesis and inhibition of binding to the cocaine receptor.
Journal of medicinal chemistry 1992;35(1):141-4.
1992: Anita H Lewin; Y G Gao; Philip Abraham; J W Boja; Michael J Kuhar; Frank carroll
2 beta-substituted analogues of cocaine. Synthesis and inhibition of binding to the cocaine receptor.
Journal of medicinal chemistry 1992;35(1):135-40.
1992: Michael J Kuhar
Molecular pharmacology of cocaine: a dopamine hypothesis and its implications.
Ciba Foundation symposium 1992;166():81-9; discussion 89-95.
1992: M C Ritz; Michael J Kuhar; Frank R George
Molecular mechanisms associated with cocaine effects. Possible relationships with effects of ethanol.
Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism 1992;10():273-302.
1991: Roxanne A Vaughan; R Simantov; R Lew; Michael J Kuhar
A rapid binding assay for solubilized dopamine transporters using [3H]WIN 35,428.
Journal of neuroscience methods 1991;40(1):9-16.
1991: S Shimada; S Kitayama; C L Lin; A Patel; E Nanthakumar; P Gregor; Michael J Kuhar; George R. Uhl
Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA.
Science (New York, N.Y.) 1991;254(5031):576-8.
1991: Frank carroll; Y G Gao; M A Rahman; Philip Abraham; K Parham; Anita H Lewin; J W Boja; Michael J Kuhar
Synthesis, ligand binding, QSAR, and CoMFA study of 3 beta-(p-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters.
Journal of medicinal chemistry 1991;34(9):2719-25.
1991: Michael J Kuhar; D G Lloyd; N Appel; H L Loats
Imaging receptors by autoradiography: computer-assisted approaches.
Journal of chemical neuroanatomy 1991;4(5):319-27.
1991: G Battaglia; John Sharkey; Michael J Kuhar; E B de Souza
Neuroanatomic specificity and time course of alterations in rat brain serotonergic pathways induced by MDMA (3,4-methylenedioxymethamphetamine): assessment using quantitative autoradiography.
Synapse (New York, N.Y.) 1991;8(4):249-60.
1991: Michael J Kuhar; M C Ritz; J W Boja
The dopamine hypothesis of the reinforcing properties of cocaine.
Trends in neurosciences 1991;14(7):299-302.
1991: S Pögün; Ursula Scheffel; Michael J Kuhar
Cocaine displaces [3H]WIN 35,428 binding to dopamine uptake sites in vivo more rapidly than mazindol or GBR 12909.
European journal of pharmacology 1991;198(2-3):203-5.
1991: Ursula Scheffel; S Pögün; M Stathis; J W Boja; Michael J Kuhar
In vivo labeling of cocaine binding sites on dopamine transporters with [3H]WIN 35,428.
The Journal of pharmacology and experimental therapeutics 1991;257(3):954-8.
1991: R Lew; R Vaughan; R Simantov; A Wilson; Michael J Kuhar
Dopamine transporters in the nucleus accumbens and the striatum have different apparent molecular weights.
Synapse (New York, N.Y.) 1991;8(2):152-3.
1991: Frank carroll; Anita H Lewin; Philip Abraham; K Parham; J W Boja; Michael J Kuhar
Synthesis and ligand binding of cocaine isomers at the cocaine receptor.
Journal of medicinal chemistry 1991;34(3):883-6.
1991: J W Boja; M A Rahman; A Philip; Anita H Lewin; Frank carroll; Michael J Kuhar
Isothiocyanate derivatives of cocaine: irreversible inhibition of ligand binding at the dopamine transporter.
Molecular pharmacology 1991;39(3):339-45.
1991: J W Boja; A Patel; Frank carroll; M A Rahman; A Philip; Anita H Lewin; Theresa A Kopajtic; Michael J Kuhar
[125I]RTI-55: a potent ligand for dopamine transporters.
European journal of pharmacology 1991;194(1):133-4.
1991: R Lew; D Grigoriadis; A Wilson; J W Boja; R Simantov; Michael J Kuhar
Dopamine transporter: deglycosylation with exo- and endoglycosidases.
Brain research 1991;539(2):239-46.
1990: Michael J Kuhar
A GABA transporter cDNA has been cloned.
Trends in neurosciences 1990;13(12):473-4.
1990: M C Ritz; J W Boja; D Grigoriadis; Robert Zaczek; Frank carroll; A H Lewis; Michael J Kuhar
[3H]WIN 35,065-2: a ligand for cocaine receptors in striatum.
Journal of neurochemistry 1990;55(5):1556-62.
1990: J W Boja; Frank carroll; M A Rahman; A Philip; Anita H Lewin; Michael J Kuhar
New, potent cocaine analogs: ligand binding and transport studies in rat striatum.
European journal of pharmacology 1990;184(2-3):329-32.
1990: Michael J Kuhar; J W Boja; Edward J Cone
Phencyclidine binding to striatal cocaine receptors.
Neuropharmacology 1990;29(3):295-7.
1990: M C Ritz; Edward J Cone; Michael J Kuhar
Cocaine inhibition of ligand binding at dopamine, norepinephrine and serotonin transporters: a structure-activity study.
Life sciences 1990;46(9):635-45.
1990: Michael J Kuhar; P M Sanchez-Roa; Dean F Wong; Robert F Dannals; D E Grigoriadis; R Lew; M Milberger
Dopamine transporter: biochemistry, pharmacology and imaging.
European neurology 1990;30 Suppl 1():15-20.
1990: Frank carroll; M A Rahman; A Philip; Anita H Lewin; J W Boja; Michael J Kuhar
Synthesis and receptor binding of cocaine analogs.
NIDA research monograph 1990;105():147-53.
1990: M A Zarbin; J K Wamsley; Michael J Kuhar
Anterograde transport of opioid receptors in rat vagus nerves and dorsal roots of spinal nerves: pharmacology and sensitivity to sodium and guanine nucleotides.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1990;81(2):267-78.
1989: J W Boja; Michael J Kuhar
[3H]cocaine binding and inhibition of [3H]dopamine uptake is similar in both the rat striatum and nucleus accumbens.
European journal of pharmacology 1989;173(2-3):215-7.
1989: Laura T Goldsmith; Joan Skurnick; Andrea Wojtczuk; M Linden; Michael J Kuhar; Gerson Weiss
The antagonistic effect of oxytocin and relaxin on rat uterine segment contractility.
American journal of obstetrics and gynecology 1989;161(6 Pt 1):1644-9.
1989: C L Schmidt; D de Ziegler; C L Gagliardi; R W Mellon; F H Taney; Michael J Kuhar; Jose M Colon; Gerson Weiss
Transfer of cryopreserved-thawed embryos: the natural cycle versus controlled preparation of the endometrium with gonadotropin-releasing hormone agonist and exogenous estradiol and progesterone (GEEP).
Fertility and sterility 1989;52(4):609-16.
1989: M Titeler; R A Lyon; Michael J Kuhar; J James Frost; Robert F Dannals; S Leonhardt; A Bullock; L T Rydelek; Donald L Price; R G Struble
Mu opiate receptors are selectively labelled by [3H]carfentanil in human and rat brain.
European journal of pharmacology 1989;167(2):221-8.
1989: D E Grigoriadis; A A Wilson; R Lew; John Sharkey; Michael J Kuhar
Dopamine transport sites selectively labeled by a novel photoaffinity probe: 125I-DEEP.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1989;9(8):2664-70.
1989: M C Ritz; Michael J Kuhar
Relationship between self-administration of amphetamine and monoamine receptors in brain: comparison with cocaine.
The Journal of pharmacology and experimental therapeutics 1989;248(3):1010-7.
1989: R Lew; D E Grigoriadis; John Sharkey; Michael J Kuhar
Dopamine transporter: solubilization from dog caudate nucleus.
Synapse (New York, N.Y.) 1989;3(4):372-5.
1989: U Scheffel; J W Boja; Michael J Kuhar
Cocaine receptors: in vivo labeling with 3H-(-)cocaine, 3H-WIN 35,065-2, and 3H-WIN 35,428.
Synapse (New York, N.Y.) 1989;4(4):390-2.
1989: Jeffrey M Witkin; Steven R Goldberg; Jonathan L Katz; Michael J Kuhar
Modulation of the lethal effects of cocaine by cholinomimetics.
Life sciences 1989;45(24):2295-301.
1989: L J Porrino; M C Ritz; N L Goodman; Lawrence G Sharpe; Michael J Kuhar; Steven R Goldberg
Differential effects of the pharmacological manipulation of serotonin systems on cocaine and amphetamine self-administration in rats.
Life sciences 1989;45(17):1529-35.
1989: M C Ritz; J W Boja; Frank R George; Michael J Kuhar
Cocaine binding sites related to drug self-administration.
NIDA research monograph 1989;95():239-46.
1989: P M Sánchez-Roa; D E Grigoriadis; Alan Wilson; John Sharkey; Robert F Dannals; Victor L Villemagne; Dean F Wong; Henry N Wagner; Michael J Kuhar
[125]I-spectramide: a novel benzamide displaying potent and selective effects at the D2 dopamine receptor.
Life sciences 1989;45(19):1821-9.
1988: John Sharkey; M C Ritz; J A Schenden; R C Hanson; Michael J Kuhar
Cocaine inhibits muscarinic cholinergic receptors in heart and brain.
The Journal of pharmacology and experimental therapeutics 1988;246(3):1048-52.
1988: Elizabeth O'Hearn; G Battaglia; E B De Souza; Michael J Kuhar; Mark E Molliver
Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1988;8(8):2788-803.
1988: John Sharkey; K A Glen; S Wolfe; Michael J Kuhar
Cocaine binding at sigma receptors.
European journal of pharmacology 1988;149(1-2):171-4.
1988: Nick E Goeders; M C Ritz; Michael J Kuhar
Buspirone enhances benzodiazepine receptor binding in vivo.
Neuropharmacology 1988;27(3):275-80.
1988: M C Ritz; Richard J Lamb; Steven R Goldberg; Michael J Kuhar
Cocaine self-administration appears to be mediated by dopamine uptake inhibition.
Progress in neuro-psychopharmacology & biological psychiatry 1988;12(2-3):233-9.
1988: Henry N Wagner; Daniel R Weinberger; J E Kleinman; M F Casanova; C J Gibbs; R E Gur; Oleh Hornykiewicz; Michael J Kuhar; J W Pettegrew; Philip Seeman
Neuroimaging and neuropathology.
Schizophrenia bulletin 1988;14(3):383-97.
1988: Michael J Kuhar; M C Ritz; John Sharkey
Cocaine receptors on dopamine transporters mediate cocaine-reinforced behavior.
NIDA research monograph 1988;88():14-22.
1988: Dean F Wong; Michael J Kuhar
In vivo PET and SPECT receptor imaging: new technology and tactics for receptor measurement.
Advances in experimental medicine and biology 1988;236():181-93.
1988: E B De Souza; W K Schmidt; Michael J Kuhar
Nalbuphine: an autoradiographic opioid receptor binding profile in the central nervous system of an agonist/antagonist analgesic.
The Journal of pharmacology and experimental therapeutics 1988;244(1):391-402.
1987: M C Ritz; Richard J Lamb; Steven R Goldberg; Michael J Kuhar
Cocaine receptors on dopamine transporters are related to self-administration of cocaine.
Science (New York, N.Y.) 1987;237(4819):1219-23.
1987: G Battaglia; SY Yeh; Elizabeth O'Hearn; Mark E Molliver; Michael J Kuhar; E B De Souza
3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites.
The Journal of pharmacology and experimental therapeutics 1987;242(3):911-6.
1987: Michael J Kuhar
Imaging receptors for drugs in neural tissue.
Neuropharmacology 1987;26(7B):911-6.
1987: Peter J Whitehouse; W W Vale; R M Zweig; Harvey S Singer; Richard Mayeux; Michael J Kuhar; Donald L Price; E B De Souza
Reductions in corticotropin releasing factor-like immunoreactivity in cerebral cortex in Alzheimer's disease, Parkinson's disease, and progressive supranuclear palsy.
Neurology 1987;37(6):905-9.
1987: Henry D Jampel; M G Lynch; R H Brown; Michael J Kuhar; E B De Souza
Beta-adrenergic receptors in human trabecular meshwork. Identification and autoradiographic localization.
Investigative ophthalmology & visual science 1987;28(5):772-9.
1987: J James Frost; A C Smith; Michael J Kuhar; Robert F Dannals; Henry N Wagner
In vivo binding of 3H-N-methylspiperone to dopamine and serotonin receptors.
Life sciences 1987;40(10):987-95.
1987: N E Goeders; Michael J Kuhar
Chronic cocaine administration induces opposite changes in dopamine receptors in the striatum and nucleus accumbens.
Alcohol and drug research 1987;7(4):207-16.
1986: Dean F Wong; Henry N Wagner; L E Tune; Robert F Dannals; Godfrey D Pearlson; Jonathan M Links; Carol A Tamminga; E P Broussolle; Hayden T Ravert; Alan Wilson; J K Toung; J Malat; J A Williams; L A O'Tuama; Solomon H Snyder; Michael J Kuhar; Albert Gjedde
Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics.
Science (New York, N.Y.) 1986;234(4783):1558-63.
1986: N E Goeders; E B De Souza; Michael J Kuhar
Benzodiazepine receptor GABA ratios: regional differences in rat brain and modulation by adrenalectomy.
European journal of pharmacology 1986;129(3):363-6.
1986: R A Lyon; M Titeler; J James Frost; Peter J Whitehouse; Dean F Wong; Henry N Wagner; Robert F Dannals; Jonathan M Links; Michael J Kuhar
3H-3-N-methylspiperone labels D2 dopamine receptors in basal ganglia and S2 serotonin receptors in cerebral cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1986;6(10):2941-9.
1986: E B De Souza; N E Goeders; Michael J Kuhar
Benzodiazepine receptors in rat brain are altered by adrenalectomy.
Brain research 1986;381(1):176-81.
1986: Dean F Wong; Henry N Wagner; Robert F Dannals; Jonathan M Links; Michael J Kuhar; Albert Gjedde
Response: human brain receptor distribution.
Science (New York, N.Y.) 1986;232(4755):1270-1.
1986: M A Zarbin; J K Wamsley; J M Palacios; Michael J Kuhar
Autoradiographic localization of high affinity GABA, benzodiazepine, dopaminergic, adrenergic and muscarinic cholinergic receptors in the rat, monkey and human retina.
Brain research 1986;374(1):75-92.
1986: Dean F Wong; Albert Gjedde; Henry N Wagner; Robert F Dannals; K H Douglass; Jonathan M Links; Michael J Kuhar
Quantification of Neuroreceptors in the living human brain. II. Inhibition studies of receptor density and affinity.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1986;6(2):147-53.
1986: E B De Souza; Peter J Whitehouse; Michael J Kuhar; Donald L Price; W W Vale
Reciprocal changes in corticotropin-releasing factor (CRF)-like immunoreactivity and CRF receptors in cerebral cortex of Alzheimer's disease.
Nature 1986;319(6054):593-5.
1986: E B De Souza; Michael J Kuhar
Corticotropin-releasing factor receptors: autoradiographic identification.
Research publications - Association for Research in Nervous and Mental Disease 1986;64():179-98.
1986: E B De Souza; Michael J Kuhar
Corticotropin-releasing factor receptors in the pituitary gland and central nervous system: methods and overview.
Methods in enzymology 1986;124():560-90.
1986: Michael J Kuhar; E B De Souza; JR Unnerstall
Neurotransmitter receptor mapping by autoradiography and other methods.
Annual review of neuroscience 1986;9():27-59.
1985: E B De Souza; Thomas R Insel; M H Perrin; J Rivier; W W Vale; Michael J Kuhar
Corticotropin-releasing factor receptors are widely distributed within the rat central nervous system: an autoradiographic study.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1985;5(12):3189-203.
1985: W R Millington; E Aizenman; G G Bierkamper; M A Zarbin; Michael J Kuhar
Axonal transport of alpha-bungarotoxin binding sites in rat sciatic nerve.
Brain research 1985;340(2):269-76.
1985: Peter J Whitehouse; R R Trifiletti; B E Jones; Susan E Folstein; Donald L Price; Solomon H Snyder; Michael J Kuhar
Neurotransmitter receptor alterations in Huntington's disease: autoradiographic and homogenate studies with special reference to benzodiazepine receptor complexes.
Annals of neurology 1985;18(2):202-10.
1985: N E Goeders; Michael J Kuhar
Benzodiazepine receptor binding in vivo with [3H]-Ro 15-1788.
Life sciences 1985;37(4):345-55.
1985: N E Goeders; W D Horst; R O'Brien; G Bautz; Michael J Kuhar
Benzodiazepine receptor binding with a new ligand, Ro 22-8515.
European journal of pharmacology 1985;113(1):147-8.
1985: M Titeler; E B De Souza; Michael J Kuhar
[3H]Nitrendipine binding to calcium channels in bovine and rat pituitary.
Journal of neurochemistry 1985;44(6):1955-8.
1985: E B De Souza; Thomas R Insel; M H Perrin; J Rivier; W W Vale; Michael J Kuhar
Differential regulation of corticotropin-releasing factor receptors in anterior and intermediate lobes of pituitary and in brain following adrenalectomy in rats.
Neuroscience letters 1985;56(2):121-8.
1985: E B De Souza; H Seifert; Michael J Kuhar
Vasoactive intestinal peptide receptor localization in rat forebrain by autoradiography.
Neuroscience letters 1985;56(2):113-20.
1985: E B De Souza; M H Perrin; Peter J Whitehouse; J Rivier; W Vale; Michael J Kuhar
Corticotropin-releasing factor receptors in human pituitary gland: autoradiographic localization.
Neuroendocrinology 1985;40(5):419-22.
1985: Peter J Whitehouse; J K Wamsley; M A Zarbin; Donald L Price; Michael J Kuhar
Neurotransmitter receptors in amyotrophic lateral sclerosis: possible relationship to sparing of eye movements.
Annals of neurology 1985;17(5):518.
1985: R R Anholt; E B De Souza; Michael J Kuhar; Solomon H Snyder
Depletion of peripheral-type benzodiazepine receptors after hypophysectomy in rat adrenal gland and testis.
European journal of pharmacology 1985;110(1):41-6.
1985: M A Zarbin; Michael J Kuhar; T L O'Donohue; S S Wolf; T W Moody
Autoradiographic localization of (125I-Tyr4)bombesin-binding sites in rat brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1985;5(2):429-37.
1985: Henry N Wagner; Robert F Dannals; J James Frost; Dean F Wong; Hayden T Ravert; Alan Wilson; Jonathan M Links; H Donald Burns; Michael J Kuhar; Solomon H Snyder
Imaging neuroreceptors in the human brain in health and disease.
Radioisotopes 1985;34(2):103-7.
1985: R J Summers; J A Stephenson; Michael J Kuhar
Localization of beta adrenoceptor subtypes in rat kidney by light microscopic autoradiography.
The Journal of pharmacology and experimental therapeutics 1985;232(2):561-9.
1985: E B De Souza; R R Anholt; K M Murphy; Solomon H Snyder; Michael J Kuhar
Peripheral-type benzodiazepine receptors in endocrine organs: autoradiographic localization in rat pituitary, adrenal, and testis.
Endocrinology 1985;116(2):567-73.
1985: Dean F Wong; Henry N Wagner; Godfrey D Pearlson; Robert F Dannals; Jonathan M Links; Hayden T Ravert; Alan Wilson; S Suneja; E Bjorvvinssen; Michael J Kuhar
Dopamine receptor binding of C-11-3-N-methylspiperone in the caudate in schizophrenia and bipolar disorder: a preliminary report.
Psychopharmacology bulletin 1985;21(3):595-8.
1985: Y Inoue; Henry N Wagner; Dean F Wong; Jonathan M Links; J James Frost; Robert F Dannals; A E Rosenbaum; K Takeda; G Di Chiro; Michael J Kuhar
Atlas of dopamine receptor images (PET) of the human brain.
Journal of computer assisted tomography 1985;9(1):129-40.
1985: Michael J Kuhar; JR Unnerstall; E B De Souza
Receptor mapping in neuropharmacology by autoradiography: some technical problems.
NIDA research monograph 1985;62():1-12.
1984: H Donald Burns; Robert F Dannals; B Langström; Hayden T Ravert; S E Zemyan; T Duelfer; Dean F Wong; J James Frost; Michael J Kuhar; Henry N Wagner
(3-N-[11C]methyl)spiperone, a ligand binding to dopamine receptors: radiochemical synthesis and biodistribution studies in mice.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1984;25(11):1222-7.
1984: S J Peroutka; Michael J Kuhar
Autoradiographic localization of 5-HT1 receptors to human and canine basilar arteries.
Brain research 1984;310(1):193-6.
1984: George R. Uhl; Peter J Whitehouse; Donald L Price; W W Tourtelotte; Michael J Kuhar
Parkinson's disease: depletion of substantia nigra neurotensin receptors.
Brain research 1984;308(1):186-90.
1984: H Lepor; Michael J Kuhar
Characterization of muscarinic cholinergic receptor binding in the vas deferens, bladder, prostate and penis of the rabbit.
The Journal of urology 1984;132(2):392-6.
1984: Peter J Whitehouse; D Lynch; Michael J Kuhar
Effects of postmortem delay and temperature on neurotransmitter receptor binding in a rat model of the human autopsy process.
Journal of neurochemistry 1984;43(2):553-9.
1984: H Lepor; Michael J Kuhar
Characterization and localization of the muscarinic cholinergic receptor in human prostatic tissue.
The Journal of urology 1984;132(2):397-402.
1984: E B De Souza; Michael J Kuhar
Dopamine receptors in the anterior lobe of the human pituitary gland: autoradiographic localization.
Brain research 1984;306(1-2):391-5.
1984: E B De Souza; M H Perrin; Thomas R Insel; J Rivier; W W Vale; Michael J Kuhar
Corticotropin-releasing factor receptors in rat forebrain: autoradiographic identification.
Science (New York, N.Y.) 1984;224(4656):1449-51.
1984: George R. Uhl; Michael J Kuhar
Chronic neuroleptic treatment enhances neurotensin receptor binding in human and rat substantia nigra.
Nature 1984;309(5966):350-2.
1984: E B De Souza; M H Perrin; J Rivier; W W Vale; Michael J Kuhar
Corticotropin-releasing factor receptors in rat pituitary gland: autoradiographic localization.
Brain research 1984;296(1):202-7.
1984: J K Wamsley; M A Zarbin; Michael J Kuhar
Distribution of muscarinic cholinergic high and low affinity agonist binding sites: a light microscopic autoradiographic study.
Brain research bulletin 1984;12(3):233-43.
1984: JR Unnerstall; T A Kopajtic; Michael J Kuhar
Distribution of alpha 2 agonist binding sites in the rat and human central nervous system: analysis of some functional, anatomic correlates of the pharmacologic effects of clonidine and related adrenergic agents.
Brain research 1984;319(1):69-101.
1984: G T Smith; Timothy H Moran; J T Coyle; Michael J Kuhar; T L O'Donahue; Paul R McHugh
Anatomic localization of cholecystokinin receptors to the pyloric sphincter.
The American journal of physiology 1984;246(1 Pt 2):R127-30.
1984: Michael J Kuhar; JR Unnerstall
Mapping receptors for alpha 2-agonists in the central nervous system.
Journal of cardiovascular pharmacology 1984;6 Suppl 3():S536-42.
1983: W J Freed; G N Ko; D L Niehoff; Michael J Kuhar; Barry Hoffer; Lars Olson; H E Cannon-Spoor; J M Morihisa; R J Wyatt
Normalization of spiroperidol binding in the denervated rat striatum by homologous grafts of substantia nigra.
Science (New York, N.Y.) 1983;222(4626):937-9.
1983: M M Lo; D L Niehoff; Michael J Kuhar; Solomon H Snyder
Differential localization of type I and type II benzodiazepine binding sites in substantia nigra.
Nature 1983;306(5938):57-60.
1983: D L Niehoff; Michael J Kuhar
Benzodiazepine receptors: localization in rat amygdala.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1983;3(10):2091-7.
1983: Henry N Wagner; H Donald Burns; Robert F Dannals; Dean F Wong; B Langstrom; T Duelfer; J James Frost; Hayden T Ravert; Jonathan M Links; S B Rosenbloom; S E Lukas; A V Kramer; Michael J Kuhar
Imaging dopamine receptors in the human brain by positron tomography.
Science (New York, N.Y.) 1983;221(4617):1264-6.
1983: M A Zarbin; J M Palacios; J K Wamsley; Michael J Kuhar
Axonal transport of beta-adrenergic receptors. Antero- and retrogradely transported receptors differ in agonist affinity and nucleotide sensitivity.
Molecular pharmacology 1983;24(2):341-8.
1983: M M Lo; D L Niehoff; Michael J Kuhar; Solomon H Snyder
Autoradiographic differentiation of multiple benzodiazepine receptors by detergent solubilization and pharmacologic specificity.
Neuroscience letters 1983;39(1):37-44.
1983: D L Niehoff; R D Mashal; Michael J Kuhar
Benzodiazepine receptors: preferential stimulation of Type 1 receptors by pentobarbital.
European journal of pharmacology 1983;92(1-2):131-4.
1983: R J Summers; Michael J Kuhar
Autoradiographic localization of beta-adrenoceptors in rat kidney.
European journal of pharmacology 1983;91(2-3):305-10.
1983: Peter J Whitehouse; J K Wamsley; M A Zarbin; Donald L Price; W W Tourtellotte; Michael J Kuhar
Amyotrophic lateral sclerosis: alterations in neurotransmitter receptors.
Annals of neurology 1983;14(1):8-16.
1983: R R Goodman; Michael J Kuhar; Lynda D Hester; Solomon H Snyder
Adenosine receptors: autoradiographic evidence for their location on axon terminals of excitatory neurons.
Science (New York, N.Y.) 1983;220(4600):967-9.
1983: JR Unnerstall; M E Molliver; Michael J Kuhar; J M Palacios
Ontogeny of opiate binding sites in the hippocampus, olfactory bulb and other regions of the rat forebrain by autoradiographic methods.
Brain research 1983;283(2-3):157-69.
1983: M A Zarbin; Robert B Innis; J K Wamsley; Solomon H Snyder; Michael J Kuhar
Autoradiographic localization of cholecystokinin receptors in rodent brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1983;3(4):877-906.
1983: S S Wolf; T W Moody; T L O'Donohue; M A Zarbin; Michael J Kuhar
Autoradiographic visualization of rat brain binding sites for bombesin-like peptides.
European journal of pharmacology 1983;87(1):163-4.
1983: S F Atweh; Michael J Kuhar
Distribution and physiological significance of opioid receptors in the brain.
British medical bulletin 1983;39(1):47-52.
1982: Michael J Kuhar; JR Unnerstall
In vitro labeling receptor autoradiography: loss of label during ethanol dehydration and preparative procedures.
Brain research 1982;244(1):178-81.
1982: J M Palacios; Michael J Kuhar; Stanley I Rapoport; E D London
Effects of gamma-aminobutyric acid agonist and antagonist drugs on local cerebral glucose utilization.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1982;2(7):853-60.
1982: M A Zarbin; J K Wamsley; Michael J Kuhar
Axonal transport of muscarinic cholinergic receptors in rat vagus nerve: high and low affinity agonist receptors move in opposite directions and differ in nucleotide sensitivity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1982;2(7):934-41.
1982: JR Unnerstall; D L Niehoff; Michael J Kuhar; J M Palacios
Quantitative receptor autoradiography using [3H]ultrofilm: application to multiple benzodiazepine receptors.
Journal of neuroscience methods 1982;6(1-2):59-73.
1982: D L Niehoff; R D Mashal; W D Horst; R A O'Brien; J M Palacios; Michael J Kuhar
Binding of a radiolabeled triazolopyridazine to a subtype of benzodiazepine receptor in the rat cerebellum.
The Journal of pharmacology and experimental therapeutics 1982;221(3):670-5.
1982: Michael J Kuhar
Receptors for clonidine in brain: insights into therapeutic actions.
The Journal of clinical psychiatry 1982;43(6 Pt 2):17-9.
1982: J K Wamsley; M A Zarbin; W S Young; Michael J Kuhar
Distribution of opiate receptors in the monkey brain: an autoradiographic study.
Neuroscience 1982;7(3):595-613.
1982: J Palacios; Michael J Kuhar
Beta adrenergic receptor localization in rat brain by light microscopic autoradiography.
Neurochemistry international 1982;4(6):473-90.
1982: M A Zarbin; J K Wamsley; Michael J Kuhar
Peptide receptors undergo axonal transport in the rat vagus nerve.
Advances in biochemical psychopharmacology 1982;33():463-70.
1981: J M Palacios; Michael J Kuhar
Neurotensin receptors are located on dopamine-containing neurones in rat midbrain.
Nature 1981;294(5841):587-9.
1981: J K Wamsley; J M Palacios; Michael J Kuhar
Autoradiographic localization of opioid receptors in the mammalian retina.
Neuroscience letters 1981;27(1):19-24.
1981: J M Palacios; Michael J Kuhar
Ontogeny of high-affinity GABA and benzodiazepine receptors in the rat cerebellum: an autoradiographic study.
Brain research 1981;254(4):531-9.
1981: J M Palacios; J K Wamsley; Michael J Kuhar
High affinity GABA receptors-autoradiographic localization.
Brain research 1981;222(2):285-307.
1981: J M Palacios; D L Niehoff; Michael J Kuhar
Receptor autoradiography with tritium-sensitive film: potential for computerized densitometry.
Neuroscience letters 1981;25(2):101-5.
1981: JR Unnerstall; Michael J Kuhar; D L Niehoff; J M Palacios
Benzodiazepine receptors are coupled to a subpopulation of gamma-aminobutyric acid (GABA) receptors: evidence from a quantitative autoradiographic study.
The Journal of pharmacology and experimental therapeutics 1981;218(3):797-804.
1981: M A Zarbin; J K Wamsley; Robert B Innis; Michael J Kuhar
Cholecystokinin receptors: presence and axonal flow in the rat vagus nerve.
Life sciences 1981;29(7):697-705.
1981: J K Wamsley; M A Zarbin; Michael J Kuhar
Muscarinic cholinergic receptors flow in the sciatic nerve.
Brain research 1981;217(1):155-61.
1981: Michael J Kuhar; N Taylor; J K Wamsley; E C Hulme; N J Birdsall
Muscarinic cholinergic receptor localization in brain by electron microscopic autoradiography.
Brain research 1981;216(1):1-9.
1981: J M Palacios; J K Wamsley; Michael J Kuhar
GABA benzodiazepine and histamine-H1 receptors in the guinea pig cerebellum: effects of kainic acid injections studied by autoradiographic methods.
Brain research 1981;214(1):155-62.
1981: J M Palacios; D L Niehoff; Michael J Kuhar
[3H]Spiperone binding sites in brain: autoradiographic localization of multiple receptors.
Brain research 1981;213(2):277-89.
1981: J M Palacios; Michael J Kuhar; Stanley I Rapoport; E D London
Increases and decreases in local cerebral glucose utilization in response to GABA agonists.
European journal of pharmacology 1981;71(2-3):333-6.
1981: M A Zarbin; Robert B Innis; J K Wamsley; Solomon H Snyder; Michael J Kuhar
Autoradiographic localization of CCK receptors in guinea pig brain.
European journal of pharmacology 1981;71(2-3):349-50.
1981: M A Zarbin; J K Wamsley; Michael J Kuhar
Glycine receptor: light microscopic autoradiographic localization with [3H]strychnine.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1981;1(5):532-47.
1981: W S Young; Michael J Kuhar
Neurotensin receptor localization by light microscopic autoradiography in rat brain.
Brain research 1981;206(2):273-85.
1981: J K Wamsley; M S Lewis; W S Young; Michael J Kuhar
Autoradiographic localization of muscarinic cholinergic receptors in rat brainstem.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1981;1(2):176-91.
1981: W S Young; D Niehoff; Michael J Kuhar; B Beer; A S Lippa
Multiple benzodiazepine receptor localization by light microscopic radiohistochemistry.
The Journal of pharmacology and experimental therapeutics 1981;216(2):425-30.
1981: W S Young; Michael J Kuhar
Anatomical mapping of clonidine (alpha-2 noradrenergic) receptors in rat brain: relationship to function.
Progress in clinical and biological research 1981;71():41-52.
1981: J K Wamsley; J M Palacios; W S Young; Michael J Kuhar
Autoradiographic determination of neurotransmitter receptor distributions in the cerebral and cerebellar cortices.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1981;29(1A Suppl):125-35.
1981: J M Palacios; J K Wamsley; M A Zarbin; Michael J Kuhar
GABA and glycine receptors in rat brain: autoradiographic localization.
Advances in biochemical psychopharmacology 1981;29():445-51.
1981: J M Palacios; JR Unnerstall; W S Young; Michael J Kuhar
Radiohistochemical studies of benzodiazepine and GABA receptors and their interactions.
Advances in biochemical psychopharmacology 1981;26():53-60.
1981: J M Palacios; J K Wamsley; Michael J Kuhar
The distribution of histamine H1-receptors in the rat brain: an autoradiographic study.
Neuroscience 1981;6(1):15-37.
1980: W S Young; Michael J Kuhar
alpha 2-Adrenergic receptors are associated with renal proximal tubules.
European journal of pharmacology 1980;67(4):493-5.
1980: J K Wamsley; M A Zarbin; N J Birdsall; Michael J Kuhar
Muscarinic cholinergic receptors: autoradiographic localization of high and low affinity agonist binding sites.
Brain research 1980;200(1):1-12.
1980: W S Young; J K Wamsley; M A Zarbin; Michael J Kuhar
Opioid receptors undergo axonal flow.
Science (New York, N.Y.) 1980;210(4465):76-8.
1980: R R Goodman; Solomon H Snyder; Michael J Kuhar; W S Young
Differentiation of delta and mu opiate receptor localizations by light microscopic autoradiography.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(10):6239-43.
1980: Leonard Murrin; J T Coyle; Michael J Kuhar
Striatal opiate receptors: pre- and postsynaptic localization.
Life sciences 1980;27(13):1175-83.
1980: F Batzold; R DeHaven; Michael J Kuhar; N Birdsall
Inhibition of high affinity choline uptake. Structure activity studies.
Biochemical pharmacology 1980;29(18):2413-6.
1980: J M Palacios; Michael J Kuhar
Beta-adrenergic-receptor localization by light microscopic autoradiography.
Science (New York, N.Y.) 1980;208(4450):1378-80.
1980: J K Wamsley; W S Young; Michael J Kuhar
Immunohistochemical localization of enkephalin in rat forebrain.
Brain research 1980;190(1):153-74.
1980: W S Young; Michael J Kuhar
Serotonin receptor localization in rat brain by light microscopic autoradiography.
European journal of pharmacology 1980;62(2-3):237-9.
1980: W S Young; Michael J Kuhar
Noradrenergic alpha 1 and alpha 2 receptors: light microscopic autoradiographic localization.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(3):1696-700.
1980: Michael J Kuhar; Nigel J M Birdsall; A S Burgen; Edward C Hulme
Ontogeny of muscarinic receptors in rat brain.
Brain research 1980;184(2):375-83.
1980: W S Young; Michael J Kuhar
Radiohistochemical localization of benzodiazepine receptors in rat brain.
The Journal of pharmacology and experimental therapeutics 1980;212(2):337-46.
1980: J K Wamsley; W S Young; Michael J Kuhar
Anatomical localization of enkephalin immunoreactive sites in rat forebrain.
Advances in biochemical psychopharmacology 1980;22():257-70.
1980: Michael J Kuhar
The benzodiazepine receptor: anatomical aspects.
NIDA research monograph 1980;(33):12-21.
1980: W S Young; J M Palacios; Michael J Kuhar
Histochemistry of receptors.
Advances in biochemical psychopharmacology 1980;21():51-6.
1980: J M Palacios; W S Young; Michael J Kuhar
Autoradiographic localization of gamma-aminobutyric acid (GABA) receptors in the rat cerebellum.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(1):670-4.
1979: W S Young; Michael J Kuhar
A new method for receptor autoradiography: [3H]opioid receptors in rat brain.
Brain research 1979;179(2):255-70.
1979: J M Palacios; D L Niehoff; Michael J Kuhar
Ontogeny of GABA and benzodiazepine receptors: effects of Triton X-100, bromide and muscimol.
Brain research 1979;179(2):390-5.
1979: Leonard Murrin; K Gale; Michael J Kuhar
Autoradiographic localization of neuroleptic and dopamine receptors in the caudate-putamen and substantia nigra: effects of lesions.
European journal of pharmacology 1979;60(2-3):229-35.
1979: Leonard Murrin; Michael J Kuhar
Dompamine receptors in the rat frontal cortex: an autoradiographic study.
Brain research 1979;177(2):279-85.
1979: W S Young; Michael J Kuhar
Noradrenergic alpha 1 and alpha 2 receptors: autoradiographic visualization.
European journal of pharmacology 1979;59(3-4):317-9.
1979: J M Palacios; Michael J Kuhar
Choline: binding studies provide some evidence for a weak, direct agonist action in brain.
Molecular pharmacology 1979;16(3):1084-8.
1979: W S Young; Michael J Kuhar
Neurotensin receptors: autoradiographic localization in rat CNS.
European journal of pharmacology 1979;59(1-2):161-3.
1979: J M Palacios; W S Young; Michael J Kuhar
Autoradiographic localization of H1-histamine receptors in brain using 3H-mepyramine: preliminary studies.
European journal of pharmacology 1979;58(3):295-304.
1979: D L Niehoff; J M Palacios; Michael J Kuhar
In vivo receptor binding: attempts to improve specific/non-specific ratios.
Life sciences 1979;25(10):819-26.
1979: W S Young; Michael J Kuhar
Autoradiographic localisation of benzodiazepine receptors in the brains of humans and animals.
Nature 1979;280(5721):391-4.
1979: N Klemm; Leonard Murrin; Michael J Kuhar
Neuroleptic and dopamine receptors: autoradiographic localization of [3H]spiperone in rat brain.
Brain research 1979;169(1):1-9.
1979: N Klemm; Michael J Kuhar
Post-mortem changes in high affinity choline uptake.
Journal of neurochemistry 1979;32(5):1487-94.
1979: George R. Uhl; R R Goodman; Michael J Kuhar; S R Childers; Solomon H Snyder
Immunohistochemical mapping of enkephalin containing cell bodies, fibers and nerve terminals in the brain stem of the rat.
Brain research 1979;166(1):75-94.
1979: Michael J Kuhar
Sodium-dependent high affinity choline uptake.
Progress in brain research 1979;49():71-6.
1979: Michael J Kuhar; L L Mak; Paul S Lietman
Autoradiographic localization of [3H]gentamicin in the proximal renal tubules of mice.
Antimicrobial agents and chemotherapy 1979;15(1):131-3.
1979: Michael J Kuhar; George R. Uhl
Histochemical localization of opiate receptors and the enkephalins.
Advances in biochemical psychopharmacology 1979;20():53-68.
1978: J T Coyle; M E Molliver; Michael J Kuhar
In situ injection of kainic acid: a new method for selectively lesioning neural cell bodies while sparing axons of passage.
The Journal of comparative neurology 1978;180(2):301-23.
1978: W S Young; George R. Uhl; Michael J Kuhar
Iontophoresis of neurotensin in the area of the locus coeruleus.
Brain research 1978;150(2):431-5.
1978: Michael J Kuhar; M A Zarbin
Synaptosomal transport: a chloride dependence for choline, GABA, glycine and several other compounds.
Journal of neurochemistry 1978;31(1):251-6.
1978: George R. Uhl; Michael J Kuhar; S H Synder
Enkephalin-containing pathway: amygdaloid efferents in the stria terminalis.
Brain research 1978;149(1):223-8.
1978: Leonard Murrin; M S Lewis; Michael J Kuhar
Amino acid transport: alterations due to synaptosomal depolarization.
Life sciences 1978;22(22):2009-16.
1978: Michael J Kuhar
Histochemical localization of opiate receptors and opioid peptides.
Federation proceedings 1978;37(2):153-7.
1978: George R. Uhl; R R Goodman; Michael J Kuhar; Solomon H Snyder
Enkephalin and neurotensin: immunohistochemical localization and identification of an amygdalofugal pathway.
Advances in biochemical psychopharmacology 1978;18():71-87.
1978: Michael J Kuhar; Leonard Murrin; A T Malouf; N Klemm
Dopamine receptor binding in vivo: the feasibility of autoradiographic studies.
Life sciences 1978;22(2):203-10.
1978: Michael J Kuhar; Leonard Murrin
Sodium-dependent, high affinity choline uptake.
Journal of neurochemistry 1978;30(1):15-21.
1978: Michael J Kuhar
Opiate receptors: some anatomical and physiological aspects.
Annals of the New York Academy of Sciences 1978;311():35-48.
1978: S F Atweh; Leonard Murrin; Michael J Kuhar
Presynaptic localization of opiate receptors in the vagal and accessory optic systems: an autoradiographic study.
Neuropharmacology 1978;17(1):65-71.
1977: Leonard Murrin; S J Enna; Michael J Kuhar
Autoradiographic localization of [3H]reserpine binding sites in rat brain.
The Journal of pharmacology and experimental therapeutics 1977;203(3):564-74.
1977: S F Atweh; Michael J Kuhar
Autoradiographic localization of opiate receptors in rat brain. III. The telencephalon.
Brain research 1977;134(3):393-405.
1977: Leonard Murrin; R N DeHaven; Michael J Kuhar
On the relationship between (3H)choline uptake activation and (3H)acetylcholine release.
Journal of neurochemistry 1977;29(4):681-7.
1977: George R. Uhl; Michael J Kuhar; Solomon H Snyder
Neurotensin: immunohistochemical localization in rat central nervous system.
Proceedings of the National Academy of Sciences of the United States of America 1977;74(9):4059-63.
1977: W S Young; S J Bird; Michael J Kuhar
Iontophoresis of methionine-enkephalin in the locus coeruleus area.
Brain research 1977;129(2):366-70.
1977: S F Atweh; Michael J Kuhar
Autoradiographic localization of opiate receptors in rat brain. II. The brain stem.
Brain research 1977;129(1):1-12.
1977: R Simantov; Michael J Kuhar; George R. Uhl; Solomon H Snyder
Opioid peptide enkephalin: immunohistochemical mapping in rat central nervous system.
Proceedings of the National Academy of Sciences of the United States of America 1977;74(5):2167-71.
1977: S F Atweh; Michael J Kuhar
Autoradiographic localization of opiate receptors in rat brain. I. Spinal cord and lower medulla.
Brain research 1977;124(1):53-67.
1977: S J Bird; Michael J Kuhar
Iontophoretic application of opiates to the locus coeruleus.
Brain research 1977;122(3):523-33.
1976: Leonard Murrin; Michael J Kuhar
Activation of high-affinity choline uptake in vitro by depolarizing agents.
Molecular pharmacology 1976;12(6):1082-90.
1976: C B Pert; Michael J Kuhar; Solomon H Snyder
Opiate receptor: autoradiographic localization in rat brain.
Proceedings of the National Academy of Sciences of the United States of America 1976;73(10):3729-33.
1976: Michael J Kuhar; Henry I Yamamura
Localization of cholinergic muscarinic receptors in rat brain by light microscopic radioautography.
Brain research 1976;110(2):229-43.
1976: J R Simon; Michael J Kuhar
High affinity choline uptake: ionic and energy requirements.
Journal of neurochemistry 1976;27(1):93-9.
1976: S F Atweh; Michael J Kuhar
Effects of anesthetics and septal lesions and stimulation on 3H-acetylcholine formation in rat hippocampus.
European journal of pharmacology 1976;37(2):311-9.
1976: J R Simon; S Atweh; Michael J Kuhar
Sodium-dependent high affinity choline uptake: a regulatory step in the synthesis of acetylcholine.
Journal of neurochemistry 1976;26(5):909-22.
1976: R Simantov; Michael J Kuhar; Gavril W Pasternak; Solomon H Snyder
The regional distribution of a morphine-like factors enkephalin in monkey brain.
Brain research 1976;106(1):189-97.
1976: J R Simon; J F Contrera; Michael J Kuhar
Binding of [3H] kainic acid, and analogue of Lglutamate, to brain membranes.
Journal of neurochemistry 1976;26(1):141-7.
1975: Michael J Kuhar; J R Simon; N Taylor
Serotonergic synaptosomes from rat hippocampus: lack of acetylcholinesterase.
Brain research 1975;99(2):415-8.
1975: S Atweh; J R Simon; Michael J Kuhar
Utilization of sodium-dependent high affinity choline uptake in vitro as a measure of the activity of cholinergic neurons in vivo.
Life sciences 1975;17(10):1535-44.
1975: Michael J Kuhar; R N DeHaven; Henry I Yamamura; H Rommel-Spacher; J R Simon
Further evidence for cholinergic habenulo-interpeduncular neurons: pharmacologic and functional characteristics.
Brain research 1975;97(2):265-75.
1975: Solomon H Snyder; K J Chang; Michael J Kuhar; Henry I Yamamura
Biochemical indentification of the mammalian muscarinic cholinergic receptor.
Federation proceedings 1975;34(10):1915-21.
1975: S J Enna; Michael J Kuhar; Solomon H Snyder
Regional distribution of postsynaptic receptor binding for gamma-aminobutyric acid (GABA) in monkey brain.
Brain research 1975;93(1):168-74.
1975: C B Pert; Michael J Kuhar; Solomon H Snyder
Autoradiograhic localization of the opiate receptor in rat brain.
Life sciences 1975;16(12):1849-53.
1975: J R Simon; Michael J Kuhar
Impulse-flow regulation of high affinity choline uptake in brain cholinergic nerve terminals.
Nature 1975;255(5504):162-3.
1975: Michael J Kuhar; Henry I Yamamura
Light autoradiographic localisation of cholinergic muscarinic receptors in rat brain by specific binding of a potent antagonist.
Nature 1975;253(5492):560-1.
1975: B S Bunney; J R Walters; Michael J Kuhar; Robert H Roth; G K Aghajanian
D & L amphetamine stereoisomers: comparative potencies in affecting the firing of central dopaminergic and noradrenergic neurons.
Psychopharmacology communications 1975;1(2):177-90.
1975: H Rommelspacher; Michael J Kuhar
Effects of dopaminergic drugs and acute medial forebrain bundle lesions on striatal acetylcholine levels.
Life sciences 1975;16(1):65-70.
1975: H Rommelspacher; Michael J Kuhar
Effects of drugs and axotomy on acetylcholine levels in central cholinergic neurons.
Naunyn-Schmiedeberg's archives of pharmacology 1975;291(1):17-21.
1975: H Rommelspacher; Michael J Kuhar
Proceedings: Effect of drugs on alterations of neuronal impulse flow of a central cholinergic tract.
Naunyn-Schmiedeberg's archives of pharmacology 1975;287 Suppl():R10.
1974: H Rommelspacher; Michael J Kuhar
Effects of electrical stimulation on acetylcholine levels in central cholinergic nerve terminals.
Brain research 1974;81(2):243-51.
1974: R J Owellen; D W Donigian; C A Hartke; R M Dickerson; Michael J Kuhar
The binding of vinblastine to tubulin and to particulate fractions of mammalian brain.
Cancer research 1974;34(12):3180-6.
1974: Henry I Yamamura; Michael J Kuhar; Solomon H Snyder
In vivo identification of muscarinic cholinergic receptor binding in rat brain.
Brain research 1974;80(1):170-6.
1974: H Rommelspacher; Alan M Goldberg; Michael J Kuhar
Action of hemicholinium-3 on cholinergic nerve terminals after alteration of neuronal impulse flow.
Neuropharmacology 1974;13(10-11):1015-23.
1974: K Dismukes; Michael J Kuhar; Solomon H Snyder
Brain histamine alterations after hypothalamic isolation.
Brain research 1974;78(1):144-51.
1974: Michael J Kuhar; H Rommelspacher
Acetylcholinesterase-staining synaptosomes from rat hippocampus: relative frequency and tentative estimation of internal concentration of free or 'labile bound' acetylcholine.
Brain research 1974;77(1):85-96.
1974: Solomon H Snyder; B Brown; Michael J Kuhar
The subsynaptosomal localization of histamine, histidine decarboxylase and histamine methyltransferase in rat hypothalamus.
Journal of neurochemistry 1974;23(1):37-45.
1974: Michael J Kuhar; J R Simon
Acetylcholine uptake: lack of association with cholinergic neurons.
Journal of neurochemistry 1974;22(6):1135-7.
1974: A H Mulder; Henry I Yamamura; Michael J Kuhar; Solomon H Snyder
Release of acetylcholine from hippocampal slices by potassium depolarization: dependence on high affinity choline uptake.
Brain research 1974;70(2):372-6.
1974: J T Coyle; Michael J Kuhar
Subcellular localization of dopamine beta-hydroxylase and endogenous norepinephrine in the rat hypothalamus.
Brain research 1974;65(3):475-87.
1974: Michael J Kuhar; G K Aghajanian; Robert H Roth
Serotonin neurons: a synaptic mechanism for the reuptake of serotonin.
Advances in biochemical psychopharmacology 1974;10():287-95.
1973: Michael J Kuhar
Neurotransmitter uptake: a tool in identifying neurotransmitter-specific pathways.
Life sciences 1973;13(12):1623-34.
1973: Michael J Kuhar; C B Pert; Solomon H Snyder
Regional distribution of opiate receptor binding in monkey and human brain.
Nature 1973;245(5426):447-50.
1973: V H Sethy; Robert H Roth; Michael J Kuhar; M H Van Woert
Choline and acetylcholine: regional distribution and effect of degeneration of cholinergic nerve terminals in the rat hippocampus.
Neuropharmacology 1973;12(9):819-23.
1973: V H Sethy; Michael J Kuhar; Robert H Roth; M H Van Woert; G K Aghajanian
Cholinergic neurons: effect of acute septal lesion on acetylcholine and choline content of rat hippocampus.
Brain research 1973;55(2):481-4.
1973: G K Aghajanian; Michael J Kuhar; R H Roth
Serotonin-containing neuronal perikarya and terminals: differential effects of P-chlorophenylalanine.
Brain research 1973;54():85-101.
1973: Michael J Kuhar; G K Aghajanian
Selective accumulation of 3 H-serotonin by nerve terminals of raphe neurones: an autoradiographic study.
Nature: New biology 1973;241(110):187-9.
1973: Michael J Kuhar; V H Sethy; Robert H Roth; G K Aghajanian
Choline: selective accumulation by central cholinergic neurons.
Journal of neurochemistry 1973;20(2):581-93.
1972: G Bustos; Michael J Kuhar; Robert H Roth
Effect of gamma-hydroxybutyrate and gamma-butyrolactone on dopamine synthesis and uptake by rat striatum.
Biochemical pharmacology 1972;21(19):2649-52.
1972: Michael J Kuhar; G K Aghajanian; Robert H Roth
Tryptophan hydroxylase activity and synaptosomal uptake of serotonin in discrete brain regions after midbrain raphe lesions: correlations with serotonin levels and histochemical fluorescence.
Brain research 1972;44(1):165-76.
1972: Michael J Kuhar; Robert H Roth; G K Aghajanian
Synthesis of catecholamines in the locus coeruleus from 3 H-tyrosine in vivo.
Biochemical pharmacology 1972;21(16):2280-2.
1972: Michael J Kuhar; Robert H Roth; G K Aghajanian
Synaptosomes from forebrains of rats with midbrain raphe lesions: selective reduction of serotonin uptake.
The Journal of pharmacology and experimental therapeutics 1972;181(1):36-45.
1971: Michael J Kuhar; R H Roth; G K Aghajanian
Selective reduction of tryptophan hydroxylase activity in rat forebrain after midbrain raphe lesions.
Brain research 1971;35(1):167-76.
1971: Michael J Kuhar; K M Taylor; Solomon H Snyder
The subcellular localization of histamine and histamine methyltransferase in rat brain.
Journal of neurochemistry 1971;18(8):1515-27.
1971: A R Wofsey; Michael J Kuhar; Solomon H Snyder
A unique synaptosomal fraction, which accumulates glutamic and aspartic acids, in brain tissue.
Proceedings of the National Academy of Sciences of the United States of America 1971;68(6):1102-6.
1971: Michael J Kuhar; E G Shaskan; Solomon H Snyder
The subcellular distribution of endogenous and exogenous serotonin in brain tissue: comparison of synaptosomes storing serotonin, norepinephrine, and gamma-aminobutyric acid.
Journal of neurochemistry 1971;18(3):333-43.
1971: Michael J Kuhar
A possible mechanism for the pathogenic action of monosodium glutamate.
Research communications in chemical pathology and pharmacology 1971;2(1):95-7.
1971: E Gfeller; Michael J Kuhar; Solomon H Snyder
Neurotransmitter-specific synaptosomes in rat corpus striatum: morphological variations.
Proceedings of the National Academy of Sciences of the United States of America 1971;68(1):155-9.
1970: Michael J Kuhar; A I Green; Solomon H Snyder; E Gfeller
Separation of synaptosomes storing catecholamines and gamma-aminobutyric acid in rat corpus striatum.
Brain research 1970;21(3):405-17.
1970: Michael J Kuhar; Solomon H Snyder
The subcellular distribution of free H3-glutamic acid in rat cerebral cortical slices.
The Journal of pharmacology and experimental therapeutics 1970;171(1):141-52.