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Peter Henklein

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Genes & Molecular Sequences

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Sara M Ø Solbak; Anni Vedeler; Victor Wray; Karsten Bruns; Friedrich Hahn; Petra Henklein; Peter Henklein; David Mitzner; Rebekka Niebert; René Röder; Ulrich Schubert; Alok Sharma; Torgils Fossen
Influenza A virus protein PB1-F2 from different strains shows distinct structural signatures.
Sara Marie Øie Solbak; Victor Wray; Øyvind Halskau; Friedrich Hahn; Petra Henklein; Peter Henklein; Tove Ragna Reksten; Ulrich Schubert; Torgils Fossen
HIV-1 p6 - a structured to flexible multifunctional membrane-interacting protein.
Sabrina Urban; Fang Zhao; Kathrin Textoris-Taube; Helga Bernhard; Sandrine Cadel; Tanja Dannenberg; Frédéric Ebstein; Thierry Foulon; Anne Halenius; Peter Henklein; Katharina Janek; Jan H Kessler; Ferry Ossendorp; Annette Paschen; Julia Paschke; Barbara Reimann; Dirk Schadendorf; Christin Seifert; Ulrike Seifert
The efficiency of human cytomegalovirus pp65(495-503) CD8+ T cell epitope generation is determined by the balanced activities of cytosolic and endoplasmic reticulum-resident peptidases.

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All Publications

2013: Sara M Ø Solbak; Anni Vedeler; Victor Wray; Karsten Bruns; Friedrich Hahn; Petra Henklein; Peter Henklein; David Mitzner; Rebekka Niebert; René Röder; Ulrich Schubert; Alok Sharma; Torgils Fossen
Influenza A virus protein PB1-F2 from different strains shows distinct structural signatures.
Biochimica et biophysica acta 2013;1834(2):568-82.
2013: Sara Marie Øie Solbak; Victor Wray; Øyvind Halskau; Friedrich Hahn; Petra Henklein; Peter Henklein; Tove Ragna Reksten; Ulrich Schubert; Torgils Fossen
HIV-1 p6 - a structured to flexible multifunctional membrane-interacting protein.
Biochimica et biophysica acta 2013;1828(2):816-23.
2012: Sabrina Urban; Fang Zhao; Kathrin Textoris-Taube; Helga Bernhard; Sandrine Cadel; Tanja Dannenberg; Frédéric Ebstein; Thierry Foulon; Anne Halenius; Peter Henklein; Katharina Janek; Jan H Kessler; Ferry Ossendorp; Annette Paschen; Julia Paschke; Barbara Reimann; Dirk Schadendorf; Christin Seifert; Ulrike Seifert
The efficiency of human cytomegalovirus pp65(495-503) CD8+ T cell epitope generation is determined by the balanced activities of cytosolic and endoplasmic reticulum-resident peptidases.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(2):529-38.
2012: Sara M Ø Solbak; Victor Wray; Petra Henklein; Peter Henklein; Ole Horvli; Arnt J Raae; Tove Ragna Reksten; Rene Röder; Torgils Fossen
HIV-1 p6-Another viral interaction partner to the host cellular protein cyclophilin A.
Biochimica et biophysica acta 2012;1824(4):667-78.
2011: Cheng-Chang Chen; Jens Krüger; Issara Sramala; Hao-Jen Hsu; Peter Henklein; Yi-Ming Arthur Chen; Wolfgang B Fischer
ORF8a of SARS-CoV forms an ion channel: experiments and molecular dynamics simulations.
Biochimica et biophysica acta 2011;1808(2):572-9.
2011: Sara M Ø Solbak; Victor Wray; Marte I Flydal; Petra Henklein; Peter Henklein; Ole Horvli; Manfred Nimtz; Arnt J Raae; Ulrich Schubert; Torgils Fossen
The host-pathogen interaction of human cyclophilin A and HIV-1 Vpr requires specific N-terminal and novel C-terminal domains.
BMC structural biology 2011;11():49.
2011: Jörg Votteler; Liane Neumann; Sabine Hahn; Friedrich Hahn; Pia Rauch; Kerstin Schmidt; Nicole Studtrucker; Sara M Ø Solbak; Torgils Fossen; Peter Henklein; David E Ott; Gudrun Holland; Norbert Bannert; Ulrich Schubert
Highly conserved serine residue 40 in HIV-1 p6 regulates capsid processing and virus core assembly.
Retrovirology 2011;8():11.
2010: Yihui Chen; Yalin Wu; Peter Henklein; Xiaoxu Li; Klaus Peter Hofmann; Koji Nakanishi; Oliver P Ernst
A photo-cross-linking strategy to map sites of protein-protein interactions.
Chemistry (Weinheim an der Bergstrasse, Germany) 2010;16(25):7389-94.
2010: Antje Voigt; Sandra Jäkel; Kathrin Textoris-Taube; Christin Keller; Ilse Drung; Gudrun Szalay; Karin Klingel; Peter Henklein; Karl Stangl; Peter M Kloetzel; Ulrike Kuckelkorn
Generation of in silico predicted coxsackievirus B3-derived MHC class I epitopes by proteasomes.
Amino acids 2010;39(1):243-55.
2010: Chin-Pei Chen; Clemens Kremer; Peter Henklein; Ulrich Schubert; Rainer H A Fink; Wolfgang B Fischer
Modulating the activity of the channel-forming segment of Vpr protein from HIV-1.
European biophysics journal : EBJ 2010;39(7):1089-95.
2010: Andreas Reiner; Peter Henklein; Thomas Kiefhaber
An unlocking/relocking barrier in conformational fluctuations of villin headpiece subdomain.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(11):4955-60.
2010: Sara M Solbak; Tove Ragna Reksten; Victor Wray; Karsten Bruns; Ole Horvli; Arnt J Raae; Peter Henklein; Peter Henklein; Rene Röder; David Mitzner; Ulrich Schubert; Torgils Fossen
The intriguing cyclophilin A-HIV-1 Vpr interaction: prolyl cis/trans isomerisation catalysis and specific binding.
BMC structural biology 2010;10():31.
2010: Michael Henkel; David Mitzner; Peter Henklein; Franz-Josef Meyer-Almes; Anna Moroni; Mattia L Difrancesco; Leonhard M Henkes; Michael Kreim; Stefan M Kast; Ulrich Schubert; Gerhard Thiel
The proapoptotic influenza A virus protein PB1-F2 forms a nonselective ion channel.
PloS one 2010;5(6):e11112.
2010: René Röder; Peter Henklein; Hardy Weisshoff; Clemens Mügge; Michael Pätzel; Ulrich Schubert; Louis A Carpino; Peter Henklein
On the use of N-dicyclopropylmethyl aspartyl-glycine synthone for backbone amide protection.
Journal of peptide science : an official publication of the European Peptide Society 2010;16(1):65-70.
2009: Julia Hossbach; Elke Michalsky; Peter Henklein; Marten Jaeger; Peter T Daniel; Robert Preissner
Inhibiting the inhibitors: retro-inverso Smac peptides.
Peptides 2009;30(12):2374-9.
2009: Sophie E Feuerstein; Alexander Pulvermüller; Rudolf Hartmann; Joachim Granzin; Matthias Stoldt; Peter Henklein; Oliver P Ernst; Martin Heck; Dieter Willbold; Bernd W Koenig
Helix formation in arrestin accompanies recognition of photoactivated rhodopsin.
Biochemistry 2009;48(45):10733-42.
2009: David Mitzner; Sabine Eva Dudek; Nicole Studtrucker; Darisuren Anhlan; Igor Mazur; Josef Wissing; Lothar Jänsch; Ludmilla Wixler; Karsten Bruns; Alok Sharma; Victor Wray; Peter Henklein; Stephan Ludwig; Ulrich Schubert
Phosphorylation of the influenza A virus protein PB1-F2 by PKC is crucial for apoptosis promoting functions in monocytes.
Cellular microbiology 2009;11(10):1502-16.
2009: Roland Kaufmann; Claudia Oettel; Antje Horn; Karl-Jürgen Halbhuber; Annett Eitner; Reimar Krieg; Kathrin Katenkamp; Peter Henklein; Martin Westermann; Frank D Böhmer; Rithwik Ramachandran; Mahmoud Saifeddine; Morley D Hollenberg; Utz Settmacher
Met receptor tyrosine kinase transactivation is involved in proteinase-activated receptor-2-mediated hepatocellular carcinoma cell invasion.
Carcinogenesis 2009;30(9):1487-96.
2009: Louis A Carpino; Khaled Nasr; Adel Ali Abdel-Maksoud; Ayman El-Faham; Dumitru Ionescu; Peter Henklein; Holger Wenschuh; Michael Beyermann; Eberhard Krause; Michael Bienert
Dicyclopropylmethyl peptide backbone protectant.
Organic letters 2009;11(16):3718-21.
2009: Henoch Sangjoon Hong; Nupur Bhatnagar; Matthias Ballmaier; Ulrich Schubert; Peter Henklein; Thorsten Volgmann; Hans Heiken; Reinhold E Schmidt; Dirk Meyer-Olson
Exogenous HIV-1 Vpr disrupts IFN-alpha response by plasmacytoid dendritic cells (pDCs) and subsequent pDC/NK interplay.
Immunology letters 2009;125(2):100-4.
2009: Roland Kaufmann; Peter Henklein; Petra Henklein; Utz Settmacher
Green tea polyphenol epigallocatechin-3-gallate inhibits thrombin-induced hepatocellular carcinoma cell invasion and p42/p44-MAPKinase activation.
Oncology reports 2009;21(5):1261-7.
2009: Alexander Kloss; Peter Henklein; Dagmar Siele; Marion Schmolke; Sébastien Apcher; Lothar Kuehn; Paul Sheppard; Burkhardt Dahlmann
The cell-penetrating peptide octa-arginine is a potent inhibitor of proteasome activities.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2009;72(1):219-25.
2009: Kai Hilpert; Melissa Elliott; Håvard Jenssen; Jason Kindrachuk; Christopher D Fjell; Jana Körner; Dirk F H Winkler; Lindsay L Weaver; Peter Henklein; Anne S Ulrich; Sandy H Y Chiang; Susan W Farmer; Nelly Pante; Rudolf Volkmer; Robert E W Hancock
Screening and characterization of surface-tethered cationic peptides for antimicrobial activity.
Chemistry & biology 2009;16(1):58-69.
2009: Alok Sharma; Karsten Bruns; René Röder; Peter Henklein; Jörg Votteler; Victor Wray; Ulrich Schubert
Solution structure of the equine infectious anemia virus p9 protein: a rationalization of its different ALIX binding requirements compared to the analogous HIV-p6 protein.
BMC structural biology 2009;9():74.
2009: Peter Henklein; René Röder; Hardy Weisshoff; Peter Henklein; Louis A Carpino
The Dcpm protecting group is a useful alternative to the Hmb residue.
Advances in experimental medicine and biology 2009;611():247-8.
2008: Cordula Petter; Christa Scholz; Helga Wessner; Gerd Hansen; Peter Henklein; Takeshi Watanabe; Wolfgang Ernst Hoehne
Phage display screening for peptidic chitinase inhibitors.
Journal of molecular recognition : JMR 2008;21(6):401-9.
2008: René Röder; Karsten Bruns; Alok Sharma; André Eissmann; Friedrich Hahn; Nicole Studtrucker; Torgils Fossen; Victor Wray; Peter Henklein; Ulrich Schubert
Synthesis of full length PB1-F2 influenza A virus proteins from 'Spanish flu' and 'bird flu'.
Journal of peptide science : an official publication of the European Peptide Society 2008;14(8):954-62.
2008: Yihui Chen; Rolf Herrmann; Nathan Fishkin; Peter Henklein; Koji Nakanishi; Oliver P Ernst
Synthesis and spectroscopic characterization of photo-affinity peptide ligands to study rhodopsin-G protein interaction.
Photochemistry and photobiology 2008;84(4):831-8.
2008: Britta Strehl; Kathrin Textoris-Taube; Sandra Jäkel; Antje Voigt; Peter Henklein; Ulrich Steinhoff; Peter-Michael Kloetzel; Ulrike Kuckelkorn
Antitopes define preferential proteasomal cleavage site usage.
The Journal of biological chemistry 2008;283(26):17891-7.
2008: Bettina K J Hetfeld; Andreas Peth; Xiao-Ming Sun; Peter Henklein; Gerald M Cohen; Wolfgang Dubiel
The COP9 signalosome-mediated deneddylation is stimulated by caspases during apoptosis.
Apoptosis : an international journal on programmed cell death 2008;13(2):187-95.
2007: Jorge Cancino; Carolina Torrealba; Alejandro Soza; María Isabel Yuseff; Diego Gravotta; Peter Henklein; Enrique Rodriguez-Boulan; Alfonso González
Antibody to AP1B adaptor blocks biosynthetic and recycling routes of basolateral proteins at recycling endosomes.
Molecular biology of the cell 2007;18(12):4872-84.
2007: Jörg Votteler; Nicole Studtrucker; Stefan Sörgel; Jan Münch; Elke Rücker; Frank Kirchhoff; Bernhard Schick; Peter Henklein; Torgils Fossen; Karsten Bruns; Alok Sharma; Victor Wray; Ulrich Schubert
Proline 35 of human immunodeficiency virus type 1 (HIV-1) Vpr regulates the integrity of the N-terminal helix and the incorporation of Vpr into virus particles and supports the replication of R5-tropic HIV-1 in human lymphoid tissue ex vivo.
Journal of virology 2007;81(17):9572-6.
2007: Heiko Neuss; Xiaohua Huang; Bettina K J Hetfeld; Rupal Deva; Peter Henklein; Santosh Nigam; Julian W Mall; Wolfgang Schwenk; Wolfgang Dubiel
The ubiquitin- and proteasome-dependent degradation of COX-2 is regulated by the COP9 signalosome and differentially influenced by coxibs.
Journal of molecular medicine (Berlin, Germany) 2007;85(9):961-70.
2007: Dwayne Bisgrove; Tokameh Mahmoudi; Peter Henklein; Eric Verdin
Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(34):13690-5.
2007: Jacob Stewart-Ornstein; Adam P Hitchcock; Daniel Hernández Cruz; Peter Henklein; Joerg Overhage; Kai Hilpert; John D Hale; Robert E W Hancock
Using intrinsic X-ray absorption spectral differences to identify and map peptides and proteins.
The journal of physical chemistry. B 2007;111(26):7691-9.
2007: Rodolfo G Goya; Paula C Reggiani; Silvan M Vesenbeckh; Jean-Marie Pléau; Yolanda E Sosa; Gloria Cónsole; Rüdiger Schade; Peter Henklein; Mireille Dardenne
Thymulin gene therapy prevents the reduction in circulating gonadotropins induced by thymulin deficiency in mice.
American journal of physiology. Endocrinology and metabolism 2007;293(1):E182-7.
2007: Roland Kaufmann; Stephanie Rahn; Kristin Pollrich; Julia Hertel; Yves Dittmar; Merten Hommann; Peter Henklein; Christoph Biskup; Martin Westermann; Morley D Hollenberg; Utz Settmacher
Thrombin-mediated hepatocellular carcinoma cell migration: cooperative action via proteinase-activated receptors 1 and 4.
Journal of cellular physiology 2007;211(3):699-707.
2007: Kathrin Textoris-Taube; Peter Henklein; Sylvie Pollmann; Theresa Bergann; Hardy Weisshoff; Ulrike Seifert; Ilse Drung; Clemens Mügge; Alice J A M Sijts; Peter-M Kloetzel; Ulrike Kuckelkorn
The N-terminal flanking region of the TRP2360-368 melanoma antigen determines proteasome activator PA28 requirement for epitope liberation.
The Journal of biological chemistry 2007;282(17):12749-54.
2007: Christopher Aisenbrey; Philippe Bertani; Peter Henklein; Burkhard Bechinger
Structure, dynamics and topology of membrane polypeptides by oriented 2H solid-state NMR spectroscopy.
European biophysics journal : EBJ 2007;36(4-5):451-60.
2007: Karsten Bruns; Nicole Studtrucker; Alok Sharma; Torgils Fossen; David Mitzner; André Eissmann; Uwe Tessmer; René Röder; Peter Henklein; Victor Wray; Ulrich Schubert
Structural characterization and oligomerization of PB1-F2, a proapoptotic influenza A virus protein.
The Journal of biological chemistry 2007;282(1):353-63.
2007: Ashok Balasubramanyam; Harry J Mersmann; Farook Jahoor; Terry M Phillips; Rajagopal V Sekhar; Ulrich Schubert; Baljinder Brar; Dinakar Iyer; E O'Brian Smith; Hideko Takahashi; Huiyan Lu; Peter Anderson; Tomoshige Kino; Peter Henklein; Jeffrey Kopp
Effects of transgenic expression of HIV-1 Vpr on lipid and energy metabolism in mice.
American journal of physiology. Endocrinology and metabolism 2007;292(1):E40-8.
2006: Rolf Herrmann; Martin Heck; Peter Henklein; Christiane Kleuss; Victor Wray; Klaus Peter Hofmann; Oliver P Ernst
Rhodopsin-transducin coupling: role of the Galpha C-terminus in nucleotide exchange catalysis.
Vision research 2006;46(27):4582-93.
2006: Rolf Herrmann; Martin Heck; Peter Henklein; Klaus Peter Hofmann; Oliver P Ernst
Signal transfer from GPCRs to G proteins: role of the G alpha N-terminal region in rhodopsin-transducin coupling.
The Journal of biological chemistry 2006;281(40):30234-41.
2006: Kai Hilpert; Melissa R Elliott; Rudolf Volkmer-Engert; Peter Henklein; Oreola Donini; Qun Zhou; Dirk F H Winkler; Robert E W Hancock
Sequence requirements and an optimization strategy for short antimicrobial peptides.
Chemistry & biology 2006;13(10):1101-7.
2006: Mahmoud Ismail; Peter Henklein; Xiaohua Huang; Chris Braumann; Ralph I Rückert; Wolfgang Dubiel
Identification of HIV-1 Tat peptides for future therapeutic angiogenesis.
European journal of haematology 2006;77(2):157-65.
2006: Sebastian Bergmann; Kerstin Junker; Peter Henklein; Morley D Hollenberg; Utz Settmacher; Roland Kaufmann
PAR-type thrombin receptors in renal carcinoma cells: PAR1-mediated EGFR activation promotes cell migration.
Oncology reports 2006;15(4):889-93.
2006: Melanie Füllbeck; Elke Michalsky; Ines S Jaeger; Peter Henklein; Hartmut Kuhn; Karola Rück-Braun; Robert Preissner
Design and biological evaluation of photo-switchable inhibitors.
Genome informatics. International Conference on Genome Informatics 2006;17(1):141-51.
2005: Torgils Fossen; Victor Wray; Karsten Bruns; Judhi Rachmat; Peter Henklein; Uwe Tessmer; Annette Maczurek; Patricia Klinger; Ulrich Schubert
Solution structure of the human immunodeficiency virus type 1 p6 protein.
The Journal of biological chemistry 2005;280(52):42515-27.
2005: Peter Henklein; Karsten Bruns; Manfred Nimtz; Victor Wray; Uwe Tessmer; Ulrich Schubert
Influenza A virus protein PB1-F2: synthesis and characterization of the biologically active full length protein and related peptides.
Journal of peptide science : an official publication of the European Peptide Society 2005;11(8):481-90.
2005: Sabine Fuchs; Harald Otto; Stefan Jehle; Peter Henklein; A Dieter Schluter
Fluorescent dendrimers with a peptide cathepsin B cleavage site for drug delivery applications.
Chemical communications (Cambridge, England) 2005;(14):1830-2.
2005: Nancy Vázquez; Teresa Greenwell-Wild; Nancy J Marinos; William D Swaim; Salvador Nares; David E Ott; Ulrich Schubert; Peter Henklein; Jan M Orenstein; Michael B. Sporn; Sharon M Wahl
Human immunodeficiency virus type 1-induced macrophage gene expression includes the p21 gene, a target for viral regulation.
Journal of virology 2005;79(7):4479-91.
2005: Roland Kaufmann; Beate Schulze; Gerd Krause; Lorenz M Mayr; Utz Settmacher; Peter Henklein
Proteinase-activated receptors (PARs)--the PAR3 Neo-N-terminal peptide TFRGAP interacts with PAR1.
Regulatory peptides 2005;125(1-3):61-6.
2005: Sara Pagans; Angelika Pedal; Brian J North; Katrin Kaehlcke; Brett L Marshall; Alexander Dorr; Claudia Hetzer-Egger; Peter Henklein; Roy Frye; Michael W McBurney; Henning Hruby; Manfred Jung; Eric Verdin; Melanie Ott
SIRT1 regulates HIV transcription via Tat deacetylation.
PLoS biology 2005;3(2):e41.
2004: Ulrike Seifert; Heike Liermann; Vito Racanelli; Anne Halenius; Manfred Wiese; Heiner Wedemeyer; Thomas Ruppert; Kay Rispeter; Peter Henklein; Alice J A M Sijts; Hartmut Hengel; Peter-M Kloetzel; Barbara Rehermann
Hepatitis C virus mutation affects proteasomal epitope processing.
The Journal of clinical investigation 2004;114(2):250-9.
2004: Rolf Herrmann; Martin Heck; Peter Henklein; Peter Henklein; Christiane Kleuss; Klaus Peter Hofmann; Oliver P Ernst
Sequence of interactions in receptor-G protein coupling.
The Journal of biological chemistry 2004;279(23):24283-90.
2004: Alejandro Soza; Andrés Norambuena; Jorge Cancino; Erwin de la Fuente; Peter Henklein; Alfonso González
Sorting competition with membrane-permeable peptides in intact epithelial cells revealed discrimination of transmembrane proteins not only at the trans-Golgi network but also at pre-Golgi stages.
The Journal of biological chemistry 2004;279(17):17376-83.
2004: Ilonka Heider; Beate Schulze; Elke Oswald; Peter Henklein; Johannes Scheele; Roland Kaufmann
PAR1-type thrombin receptor stimulates migration and matrix adhesion of human colon carcinoma cells by a PKCepsilon-dependent mechanism.
Oncology research 2004;14(10):475-82.
2004: Melanie Ott; Alexander Dorr; Claudia Hetzer-Egger; Katrin Kaehlcke; Martina Schnolzer; Peter Henklein; Philip A Cole; Ming-Ming Zhou; Eric Verdin
Tat acetylation: a regulatory switch between early and late phases in HIV transcription elongation.
Novartis Foundation symposium 2004;259():182-93; discussion 193-6, 223-5.
2003: Karsten Bruns; Torgils Fossen; Victor Wray; Peter Henklein; Uwe Tessmer; Ulrich Schubert
Structural characterization of the HIV-1 Vpr N terminus: evidence of cis/trans-proline isomerism.
The Journal of biological chemistry 2003;278(44):43188-201.
2003: Kerstin Zander; Michael P Sherman; Uwe Tessmer; Karsten Bruns; Victor Wray; Alexander T Prechtel; Evelyn Schubert; Peter Henklein; Jeremy Luban; Jason Neidleman; Warner Greene; Ulrich Schubert
Cyclophilin A interacts with HIV-1 Vpr and is required for its functional expression.
The Journal of biological chemistry 2003;278(44):43202-13.
2003: Anja Schwarz; Oliver Krätke; Michael Burwinkel; Constanze Riemer; Julia Schultz; Peter Henklein; Theresa Bamme; Michael Baier
Immunisation with a synthetic prion protein-derived peptide prolongs survival times of mice orally exposed to the scrapie agent.
Neuroscience letters 2003;350(3):187-9.
2003: Petra Kleditzsch; John Pratt; Daesety Vishnuvardhan; Peter Henklein; Rüdiger Schade; Margery C Beinfeld
Production, purification, and characterization of rat pro-CCK from serum-free adapted Drosophila cells.
Protein expression and purification 2003;31(1):56-63.
2003: Katrin Kaehlcke; Alexander Dorr; Claudia Hetzer-Egger; veronique kiermer; Peter Henklein; Martina Schnoelzer; Erwann P Loret; Philip A Cole; Eric Verdin; Melanie Ott
Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation.
Molecular cell 2003;12(1):167-76.
2003: Louis A Carpino; Dumitru Ionescu; Ayman El-Faham; Michael Beyermann; Peter Henklein; Christiane Hanay; Holger Wenschuh; Michael Bienert
Complex polyfluoride additives in Fmoc-amino acid fluoride coupling processes. Enhanced reactivity and avoidance of stereomutation.
Organic letters 2003;5(7):975-7.
2003: Ulrike Seifert; Concepción Marañón; Ayelet Shmueli; Jean-François Desoutter; Lisa Wesoloski; Katharina Janek; Peter Henklein; Susanne Diescher; Muriel Andrieu; Henri de la Salle; Toni Weinschenk; Hansjörg Schild; Diego Laderach; Anne Galy; Gaby Haas; Peter-M Kloetzel; Yuval Reiss; Anne Hosmalin
An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope.
Nature immunology 2003;4(4):375-9.
2003: Stefan Uhle; Ohad Medalia; Richard Waldron; Renate Dumdey; Peter Henklein; Dawadschargal Bech-Otschir; Xiaohua Huang; Matthias Berse; Joseph Sperling; Rüdiger Schade; Wolfgang Dubiel
Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome.
The EMBO journal 2003;22(6):1302-12.
2003: Gabriela Riemekasten; Dirk Langnickel; Fanny M Ebling; George Karpouzas; Jatinderpal Kalsi; Gunda Herberth; Betty P Tsao; Peter Henklein; Sven Langer; Gerd R Burmester; Andreas Radbruch; Falk Hiepe; Bevra H Hahn
Identification and characterization of SmD183-119-reactive T cells that provide T cell help for pathogenic anti-double-stranded DNA antibodies.
Arthritis and rheumatism 2003;48(2):475-85.
2003: Ralf Stohwasser; Hermann-Georg Holzhütter; Undine Lehmann; Peter Henklein; Peter-M Kloetzel
Hepatitis B virus HBx peptide 116-138 and proteasome activator PA28 compete for binding to the proteasome alpha4/MC6 subunit.
Biological chemistry 2003;384(1):39-49.
2002: Xiaohua Huang; Ulrike Seifert; Ulrike Salzmann; Peter Henklein; Robert Preissner; Wolfgang Henke; Alice J Sijts; Peter-M Kloetzel; Wolfgang Dubiel
The RTP site shared by the HIV-1 Tat protein and the 11S regulator subunit alpha is crucial for their effects on proteasome function including antigen processing.
Journal of molecular biology 2002;323(4):771-82.
2002: Michael P Sherman; Ulrich Schubert; Samuel Williams; Carlos M C De Noronha; Jason F Kreisberg; Peter Henklein; Warner Greene
HIV-1 Vpr displays natural protein-transducing properties: implications for viral pathogenesis.
Virology 2002;302(1):95-105.
2002: Alexander Dorr; veronique kiermer; Angelika Pedal; Hans-Richard Rackwitz; Peter Henklein; Ulrich Schubert; Ming-Ming Zhou; Eric Verdin; Melanie Ott
Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain.
The EMBO journal 2002;21(11):2715-23.
2002: Louis A Carpino; Hideko Imazumi; Ayman El-Faham; Fernando J Ferrer; Chongwu Zhang; Yunsub Lee; Bruce M Foxman; Peter Henklein; Christiane Hanay; Clemens Mügge; Holger Wenschuh; Jana Klose; Michael Beyermann; Michael Bienert
The uronium/guanidinium Peptide coupling reagents: finally the true uronium salts.
Angewandte Chemie (International ed. in English) 2002;41(3):441-5.
2002: Roland Kaufmann; U Junker; K Nuske; Martin Westermann; Peter Henklein; Johannes Scheele; Kerstin Junker
PAR-1- and PAR-3-type thrombin receptor expression in primary cultures of human renal cell carcinoma cells.
International journal of oncology 2002;20(1):177-80.
2001: Wolfgang Kuon; Hermann-Georg Holzhütter; Heiner Appel; M Grolms; Simon Kollnberger; A Traeder; Peter Henklein; E Weiss; Andreas Thiel; Roland Lauster; Paul Bowness; Andreas Radbruch; Peter-M Kloetzel; Joachim Sieper
Identification of HLA-B27-restricted peptides from the Chlamydia trachomatis proteome with possible relevance to HLA-B27-associated diseases.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(8):4738-46.
2001: C Knuehl; Pieter Spee; Thomas Ruppert; Ulrike Kuckelkorn; Peter Henklein; Jacques Neefjes; Peter-M Kloetzel
The murine cytomegalovirus pp89 immunodominant H-2Ld epitope is generated and translocated into the endoplasmic reticulum as an 11-mer precursor peptide.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(3):1515-21.
2001: Louis A Carpino; Peter Henklein; Bruce M Foxman; I Abdelmoty; B Costisella; V Wray; T Domke; Ayman El-Faham; Clemens Mügge
The solid state and solution structure of HAPyU.
The Journal of organic chemistry 2001;66(15):5245-7.
2001: M Zieger; Svetlana Tausch; Peter Henklein; Götz Nowak; Roland Kaufmann
A novel PAR-1-type thrombin receptor signaling pathway: cyclic AMP-independent activation of PKA in SNB-19 glioblastoma cells.
Biochemical and biophysical research communications 2001;282(4):952-7.
2001: Dawadschargal Bech-Otschir; R Kraft; Xiaohua Huang; Peter Henklein; Barbara Kapelari; Christian Pollmann; Wolfgang Dubiel
COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system.
The EMBO journal 2001;20(7):1630-9.
2001: Kai Licha; Carsten Hessenius; Andreas Becker; Peter Henklein; M Bauer; S Wisniewski; Bertram Wiedenmann; Wolfhard Semmler
Synthesis, characterization, and biological properties of cyanine-labeled somatostatin analogues as receptor-targeted fluorescent probes.
Bioconjugate chemistry 2001;12(1):44-50.
2000: Angela Schulz; Karsten Bruns; Peter Henklein; Gerd Krause; Mario Schubert; Thomas Gudermann; Victor Wray; Günter Schultz; Torsten Schöneberg
Requirement of specific intrahelical interactions for stabilizing the inactive conformation of glycoprotein hormone receptors.
The Journal of biological chemistry 2000;275(48):37860-9.
2000: M Sasse; T Lengwinat; Peter Henklein; A Hlinak; Rüdiger Schade
Replacement of fetal calf serum in cell cultures by an egg yolk factor with cholecystokinin/gastrin-like immunoreactivity.
Alternatives to laboratory animals : ATLA 2000;28(6):815-31.
2000: Peter Henklein; Karsten Bruns; Michael P Sherman; Uwe Tessmer; Kai Licha; Jeffrey Kopp; Carlos M C De Noronha; Warner Greene; Victor Wray; Ulrich Schubert
Functional and structural characterization of synthetic HIV-1 Vpr that transduces cells, localizes to the nucleus, and induces G2 cell cycle arrest.
The Journal of biological chemistry 2000;275(41):32016-26.
2000: M Zieger; Wolf Oehrl; Reinhard Wetzker; Peter Henklein; Götz Nowak; Roland Kaufmann
Different signaling pathways are involved in CCK(B) receptor-mediated MAP kinase activation in COS-7 cells.
Biological chemistry 2000;381(8):763-8.
2000: Louis A Carpino; H Imazumi; Bruce M Foxman; M J Vela; Peter Henklein; Ayman El-Faham; J Klose; Michael Bienert
Comparison of the effects of 5- and 6-HOAt on model peptide coupling reactions relative to the cases for the 4- and 7-Isomers.
Organic letters 2000;2(15):2253-6.
2000: Roland Kaufmann; M Zieger; Svetlana Tausch; Peter Henklein; Götz Nowak
Meizothrombin, an intermediate of prothrombin activation, stimulates human glioblastoma cells by interaction with PAR-1-type thrombin receptors.
Journal of neuroscience research 2000;59(5):643-8.
2000: Roland Kaufmann; Stephan Patt; M Zieger; R Kraft; Svetlana Tausch; Peter Henklein; Götz Nowak
The two-receptor system PAR-1/PAR-4 mediates alpha-thrombin-induced [Ca(2+)](i) mobilization in human astrocytoma cells.
Journal of cancer research and clinical oncology 2000;126(2):91-4.
2000: Oliver P Ernst; CK Meyer; Ethan P Marin; Peter Henklein; WY Fu; Thomas P Sakmar; Klaus Peter Hofmann
Mutation of the fourth cytoplasmic loop of rhodopsin affects binding of transducin and peptides derived from the carboxyl-terminal sequences of transducin alpha and gamma subunits.
The Journal of biological chemistry 2000;275(3):1937-43.
1999: Torsten Schöneberg; Angela Schulz; Robert Grosse; Rüdiger Schade; Peter Henklein; Günter Schultz; Thomas Gudermann
A novel subgroup of class I G-protein-coupled receptors.
Biochimica et biophysica acta 1999;1446(1-2):57-70.
1999: Roland Kaufmann; Stephan Patt; R Kraft; M Zieger; Peter Henklein; Gunther Neupert; Götz Nowak
PAR 1-type thrombin receptors are involved in thrombin-induced calcium signaling in human meningioma cells.
Journal of neuro-oncology 1999;42(2):131-6.
1999: Hardy Weisshoff; C Präsang; Peter Henklein; Cornelius Frömmel; A Zschunke; Clemens Mügge
Mimicry of beta II'-turns of proteins in cyclic pentapeptides with one and without D-amino acids.
European journal of biochemistry / FEBS 1999;259(3):776-88.
1998: Roland Kaufmann; H Schafberg; M Zieger; Peter Henklein; Götz Nowak
Protein kinase C is involved in cholecystokinin octapeptide-induced proliferative action in rat glioma C6 cells.
Neuropeptides 1998;32(2):185-9.
1997: Roland Kaufmann; H Schafberg; Claudia Rudroff; Peter Henklein; Götz Nowak
Cholecystokinin B-type receptor signaling is involved in human pancreatic cancer cell growth.
Neuropeptides 1997;31(6):573-83.
1996: Roland Kaufmann; Carsten Lindschau; A Höer; Peter Henklein; A Adomeit; H Haller; Claus Liebmann; E Oberdisse; Götz Nowak
Signaling effects of alpha-thrombin and SFLLRN in rat glioma C6 cells.
Journal of neuroscience research 1996;46(6):641-51.
1996: H Weisshoff; T Wieprecht; Peter Henklein; Cornelius Frömmel; C Antz; C Mügge
Comparison of proline and N-methylnorleucine induced conformational equilibria in cyclic pentapeptides.
FEBS letters 1996;387(2-3):201-7.
1996: Siegrun Gabriel; R Grützmann; M Lemke; H J Gabriel; Peter Henklein; Helga Davidowa
Interaction of cholecystokinin and glutamate agonists within the dLGN, the dentate gyrus, and the hippocampus.
Brain research bulletin 1996;39(6):381-9.
1996: Mechthild Voits; Joerg-Peter Voigt; M Boomgaarden; Peter Henklein; Heidrun Fink
Comparison of the satiating effect of the CCKA receptor agonist A71378 with CCK-8S.
Peptides 1996;17(2):355-7.
1995: Roland Kaufmann; Peter Henklein; Götz Nowak
CCKB receptor activation results in increased [3H]thymidine incorporation in rat glioma C6 cells.
Neuropeptides 1995;29(5):241-4.
1995: H Weisshoff; K Frost; W Brandt; Peter Henklein; C Mügge; Cornelius Frömmel
Novel disulfide-constrained pentapeptides as models for beta-VIa turns in proteins.
FEBS letters 1995;372(2-3):203-9.
1995: Doris Albrecht; U Zippel; Peter Henklein
Inhibitory effects of cholecystokinin on rat's geniculate activity can be blocked by GABA-antagonists.
Neuroscience letters 1995;197(1):69-71.
1995: H Weisshoff; T Wieprecht; Peter Henklein; C Antz; C Mügge
Cyclic cholecystokinin-analog pentapeptide cyclo (Asp-Trp-Met-Asp-Phe): an unexpected solution conformation.
Biochemical and biophysical research communications 1995;213(2):506-12.
1995: U Zippel; Peter Henklein
Effects of two newly synthetized cholecystokinin tetrapeptides on the activity of single hippocampal and thalamic neurons.
Neuropeptides 1995;29(2):83-7.
1995: Roland Kaufmann; Torsten Schöneberg; Peter Henklein; R Meyer; H Martin; T Ott
Effects of guanyl nucleotides on CCKB receptor binding in brain tissue and continuous cell lines: a comparative study.
Neuropeptides 1995;29(1):63-8.
1994: Roland Kaufmann; Carsten Lindschau; Torsten Schöneberg; Peter Henklein; M Boomgaarden; H Haller; T Ott
CCKB receptor signaling in rat pituitary GH3 cells. CCK-8S-induced intracellular calcium mobilization by Ca2+ release and Ca2+ influx.
Neuropeptides 1994;27(4):211-6.
1994: Roland Kaufmann; Torsten Schöneberg; Peter Henklein; M Boomgaarden; D Sohr; T Ott
Comparative 3H-CCK-8S binding studies on CCKB-type receptors in guinea-pig cortex and continuous cell lines.
Neuropeptides 1994;26(6):429-33.
1994: U Schäfer; R Harhammer; M Boomgaarden; Reinhard Sohr; T Ott; Peter Henklein; H Repke
Binding of cholecystokinin-8 (CCK-8) peptide derivatives to CCKA and CCKB receptors.
Journal of neurochemistry 1994;62(4):1426-31.
1994: Doris Albrecht; R Müller; U Zippel; H J Gabriel; Peter Henklein; Helga Davidowa
Cholecystokinin-induced activity changes of dorsal lateral geniculate neurons in rats.
Neuroscience 1994;59(4):953-60.
1994: Roland Kaufmann; Carsten Lindschau; Torsten Schöneberg; H Haller; Peter Henklein; M Boomgaarden; T Ott
Type B cholecystokinin receptors on rat glioma C6 cells. Binding studies and measurement of intracellular calcium mobilization.
Brain research 1994;639(1):109-14.
1991: R Harhammer; U Schäfer; Peter Henklein; T Ott; H Repke
CCK-8-related C-terminal tetrapeptides: affinities for central CCKB and peripheral CCKA receptors.
European journal of pharmacology 1991;209(3):263-6.
1991: M Beyermann; Peter Henklein; A Klose; Reinhard Sohr; Michael Bienert
Effect of tertiary amine on the carbodiimide-mediated peptide synthesis.
International journal of peptide and protein research 1991;37(4):252-6.
1990: Angelina Rakovska; Kiril Milenov; Peter Henklein
Effects of a new cholecystokinin antagonist (GE 410) on the smooth muscle of the guinea pig ileum.
Experientia 1990;46(10):1037-41.
1990: M Boomgaarden; Peter Henklein; Reinhard Sohr; R Morgenstern; J Martinez; T Ott
[Synthesis and biological activity of new cholecystokinin (CCK)-analogs with a special CCK-A receptor antagonistic effect].
Die Pharmazie 1990;45(5):377-8.
1989: Peter Henklein; M Boomgaarden; B Penke; R Morgenstern; T Ott
[Synthesis and biological activity of new CCK antagonists].
Die Pharmazie 1989;44(1):61.
1988: Karen Nieber; Kiril Milenov; Angelina Rakovska; Peter Henklein; P Oehme
Responses of guinea-pig gastric, ileal and gall bladder smooth muscle to desamino-cholecystokinin-octapeptide (CCK 7).
Methods and findings in experimental and clinical pharmacology 1988;10(8):513-20.
1988: Peter Henklein; M Boomgaarden; E M Nieke; M Georgi; H Niedrich
[An improved synthesis of pentagastrin (Acignost)].
Die Pharmazie 1988;43(1):10-2.
1987: Karen Nieber; Peter Henklein; T Ott; P Oehme
[Cholecystokinin-peptides--new knowledge and possibilities for clinical use].
Zeitschrift für die gesamte innere Medizin und ihre Grenzgebiete 1987;42(18):501-6.
1987: Angelina Rakovska; Peter Henklein; Kiril Milenov; Karen Nieber; P Oehme
Suc-Tyr(SE)-Met-Gly-Trp-Met-Asp-beta-phenethylamide(410): a competitive antagonist of cholecystokinin-induced contractions in smooth muscles in vitro.
Methods and findings in experimental and clinical pharmacology 1987;9(7):429-35.
1987: Peter Henklein; B Penke; M Georgi; W R Halatsch; H Niedrich; T Ott
[Improved synthesis of the highly active cholecystokinin sequence succinyl Tyr (OSO3-)-Met-Gly-Trp-Asp-Phe-NH2].
Die Pharmazie 1987;42(6):413-4.
1986: M Böttcher; Peter Henklein; K Hoffmann; G Heder; Wolf-Eberhard Siems; H Niedrich
[Synthesis of n-substituted amino acid-p-nitrobenzyl esters as potential ACE inhibitors].
Die Pharmazie 1986;41(2):140.
1986: Peter Henklein; M Böttcher; G Heder; Wolf-Eberhard Siems; H Niedrich
[Synthesis of carbonyl-bisamino acid derivatives as potential ACE inhibitors].
Die Pharmazie 1986;41(1):56-7.