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Gloria Cristalli

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Daniela Catarzi; Vittoria Colotta; Pier Andrea Borea; Diego Dal Ben; Guido Filacchioni; Catia Lambertucci; Daniela Poli; Lucia Squarcialupi; Flavia Varano; Katia Varani; Fabrizio Vincenzi; Gloria Cristalli
Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: synthesis, structure-affinity relationships and molecular modeling studies.
Giovanni Caprioli; Manuela Cortese; Gloria Cristalli; Filippo Maggi; Luigi Odello; Massimo Ricciutelli; Gianni Sagratini; Veronica Sirocchi; Giacomo Tomassoni; Sauro Vittori
Optimization of espresso machine parameters through the analysis of coffee odorants by HS-SPME-GC/MS.
Michela Buccioni; Diego Dal Ben; Dania Giacobbe; Catia Lambertucci; Gabriella Marucci; Laura Soverchia; Ajiroghene Thomas; Rosaria Volpini; Gloria Cristalli
Innovative functional cAMP assay for studying G protein-coupled receptors: application to the pharmacological characterization of GPR17.

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All Publications

2013: Daniela Catarzi; Vittoria Colotta; Pier Andrea Borea; Diego Dal Ben; Guido Filacchioni; Catia Lambertucci; Daniela Poli; Lucia Squarcialupi; Flavia Varano; Katia Varani; Fabrizio Vincenzi; Gloria Cristalli
Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: synthesis, structure-affinity relationships and molecular modeling studies.
Bioorganic & medicinal chemistry 2013;21(1):283-94.
2012: Giovanni Caprioli; Manuela Cortese; Gloria Cristalli; Filippo Maggi; Luigi Odello; Massimo Ricciutelli; Gianni Sagratini; Veronica Sirocchi; Giacomo Tomassoni; Sauro Vittori
Optimization of espresso machine parameters through the analysis of coffee odorants by HS-SPME-GC/MS.
Food chemistry 2012;135(3):1127-33.
2011: Michela Buccioni; Diego Dal Ben; Dania Giacobbe; Catia Lambertucci; Gabriella Marucci; Laura Soverchia; Ajiroghene Thomas; Rosaria Volpini; Gloria Cristalli
Innovative functional cAMP assay for studying G protein-coupled receptors: application to the pharmacological characterization of GPR17.
Purinergic signalling 2011;7(4):463-8.
2011: Filippo Maggi; Pavol Mártonfi; Fabrizio Papa; Gianni Sagratini; Fabio Conti; Gloria Cristalli; Sauro Vittori
Volatile components of whole and different plant parts of bastard balm (Melittis melissophyllum L., Lamiaceae) collected in Central Italy and Slovakia.
Chemistry & biodiversity 2011;8(11):2057-79.
2011: Gabriella Marucci; Carmen Lammi; Michela Buccioni; Diego Dal Ben; Catia Lambertucci; Consuelo Amantini; Giorgio Santoni; Meenakshisundaram Kandhavelu; Maria Pia Abbracchio; Davide Lecca; Rosaria Volpini; Gloria Cristalli
Comparison and optimization of transient transfection methods at human astrocytoma cell line 1321N1.
Analytical biochemistry 2011;414(2):300-2.
2011: Diego Dal Ben; Catia Lambertucci; Gabriella Marucci; Ajiroghene Thomas; Rosaria Volpini; Ippolito Antonini; Michela Buccioni; Gloria Cristalli
Neuropeptide S receptor: recent updates on nonpeptide antagonist discovery.
ChemMedChem 2011;6(7):1163-71.
2011: Rosaria Volpini; Gabriella Marucci; Michela Buccioni; Diego Dal Ben; Catia Lambertucci; Carmen Lammi; Ram C Mishra; Ajiroghene Thomas; Gloria Cristalli
Evidence for the existence of a specific g protein-coupled receptor activated by guanosine.
ChemMedChem 2011;6(6):1074-80.
2011: Chiara Traini; Rosaria Volpini; Francesca Cerbai; Sara Cipriani; Gloria Cristalli; Andrea Galli; Maria Grazia Giovannini; Tommaso Mello; Felicita Pedata; Anna Maria Pugliese
P2 receptor antagonists prevent synaptic failure and extracellular signal-regulated kinase 1/2 activation induced by oxygen and glucose deprivation in rat CA1 hippocampus in vitro.
The European journal of neuroscience 2011;33(12):2203-15.
2011: Filippo Maggi; Fabio Conti; Gloria Cristalli; Claudia Giuliani; Fabrizio Papa; Gianni Sagratini; Sauro Vittori
Chemical differences in volatiles between Melittis melissophyllum L. subsp. melissophyllum and subsp. albida (Guss) P. W. Ball (Lamiaceae) determined by solid-phase microextraction (SPME) coupled with GC/FID and GC/MS.
Chemistry & biodiversity 2011;8(2):325-43.
2011: Diego Dal Ben; Michela Buccioni; C Lambertucci; Gabriella Marucci; Rosaria Volpini; Gloria Cristalli
The importance of alkynyl chain presence for the activity of adenine nucleosides/nucleotides on purinergic receptors.
Current medicinal chemistry 2011;18(10):1444-63.
2010: Diego Dal Ben; Michela Buccioni; Catia Lambertucci; Gabriella Marucci; Ajiroghene Thomas; Rosaria Volpini; Gloria Cristalli
Molecular modeling study on potent and selective adenosine A(3) receptor agonists.
Bioorganic & medicinal chemistry 2010;18(22):7923-30.
2010: Giovanni Caprioli; Gloria Cristalli; Eugenio Ragazzi; Laura Molin; Massimo Ricciutelli; Gianni Sagratini; Roberta Seraglia; Yanting Zuo; Sauro Vittori
A preliminary matrix-assisted laser desorption/ionization time-of-flight approach for the characterization of Italian lentil varieties.
Rapid communications in mass spectrometry : RCM 2010;24(19):2843-8.
2010: Giovanni Caprioli; Gloria Cristalli; Roberta Galarini; Dania Giacobbe; Massimo Ricciutelli; Sauro Vittori; Yanting Zuo; Gianni Sagratini
Comparison of two different isolation methods of benzimidazoles and their metabolites in the bovine liver by solid-phase extraction and liquid chromatography-diode array detection.
Journal of chromatography. A 2010;1217(11):1779-85.
2010: Diego Dal Ben; Ippolito Antonini; Michela Buccioni; Catia Lambertucci; Gabriella Marucci; Sauro Vittori; Rosaria Volpini; Gloria Cristalli
Molecular modeling studies on the human neuropeptide S receptor and its antagonists.
ChemMedChem 2010;5(3):371-83.
2010: Diego Dal Ben; Catia Lambertucci; Gabriella Marucci; Rosaria Volpini; Gloria Cristalli
Adenosine receptor modeling: what does the A2A crystal structure tell us?
Current topics in medicinal chemistry 2010;10(10):993-1018.
2009: Rosaria Volpini; Michela Buccioni; Diego Dal Ben; Catia Lambertucci; Carmen Lammi; Gabriella Marucci; Anna T Ramadori; Karl-Norbert Klotz; Gloria Cristalli
Synthesis and biological evaluation of 2-alkynyl-N6-methyl-5'-N-methylcarboxamidoadenosine derivatives as potent and highly selective agonists for the human adenosine A3 receptor.
Journal of medicinal chemistry 2009;52(23):7897-900.
2009: Gianni Sagratini; Yanting Zuo; Giovanni Caprioli; Gloria Cristalli; Dario Giardinà; Filippo Maggi; Laura Molin; Massimo Ricciutelli; Piero Traldi; Sauro Vittori
Quantification of soyasaponins I and betag in Italian lentil seeds by solid-phase extraction (SPE) and high-performance liquid chromatography-mass spectrometry (HPLC-MS).
Journal of agricultural and food chemistry 2009;57(23):11226-33.
2009: Thomas Borrmann; Aliaa Abdelrahman; Rosaria Volpini; Catia Lambertucci; Edgars Alksnis; Simone Gorzalka; Melanie Knospe; Anke C Schiedel; Gloria Cristalli; Christa E Müller
Structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family.
Journal of medicinal chemistry 2009;52(19):5974-89.
2009: Filippo Maggi; Massimo Bramucci; Cinzia Cecchini; Maria M Coman; Alberto Cresci; Gloria Cristalli; Giulio Lupidi; Fabrizio Papa; Luana Quassinti; Gianni Sagratini; Sauro Vittori
Composition and biological activity of essential oil of Achillea ligustica All. (Asteraceae) naturalized in central Italy: ideal candidate for anti-cariogenic formulations.
Fitoterapia 2009;80(6):313-9.
2009: Rosaria Volpini; Ram Chandra Mishra; Dhuldeo D Kachare; Diego Dal Ben; Catia Lambertucci; Ippolito Antonini; Sauro Vittori; Gabriella Marucci; Elena Sokolova; Andrea Nistri; Gloria Cristalli
Adenine-based acyclic nucleotides as novel P2X3 receptor ligands.
Journal of medicinal chemistry 2009;52(15):4596-603.
2009: Rosaria Volpini; Diego Dal Ben; Catia Lambertucci; Gabriella Marucci; Ram Chandra MISHRA; Anna Teresa Ramadori; Karl-Norbert Klotz; Maria Letizia Trincavelli; Claudia Martini; Gloria Cristalli
Adenosine A2A receptor antagonists: new 8-substituted 9-ethyladenines as tools for in vivo rat models of Parkinson's disease.
ChemMedChem 2009;4(6):1010-9.
2009: Catia Lambertucci; Ippolito Antonini; Michela Buccioni; Diego Dal Ben; Dhuldeo D Kachare; Rosaria Volpini; Karl-Norbert Klotz; Gloria Cristalli
8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands.
Bioorganic & medicinal chemistry 2009;17(7):2812-22.
2009: Michela Buccioni; Meenakshisundaram Kandhavelu; Piero Angeli; Gloria Cristalli; Diego Dal Ben; Dario Giardinà; Catia Lambertucci; Carmen Lammi; Rosaria Volpini; Gabriella Marucci
Identification of alpha1-adrenoceptor subtypes involved in contraction of young CD rat epididymal vas deferens.
European journal of pharmacology 2009;602(2-3):388-94.
2009: Gloria Cristalli; Christa E Müller; Rosaria Volpini
Recent developments in adenosine A2A receptor ligands.
Handbook of experimental pharmacology 2009;(193):59-98.
2008: Gabriella Marucci; Sara Finaurini; Michela Buccioni; Carmen Lammi; Meenakshisundaram Kandhavelu; Rosaria Volpini; Massimo Ricciutelli; Piero Angeli; Jan N M Commandeur; Gloria Cristalli
In vitro metabolism studies of new adenosine A 2A receptor antagonists.
Drug metabolism letters 2008;2(4):301-7.
2008: Ippolito Antonini; Rosaria Volpini; Diego Dal Ben; Catia Lambertucci; Gloria Cristalli
Design, synthesis, and biological evaluation of new mitonafide derivatives as potential antitumor drugs.
Bioorganic & medicinal chemistry 2008;16(18):8440-6.
2008: Svetlana Sharoyan; Alvard Antonyan; Sona Mardanyan; Giulio Lupidi; Massimiliano Cuccioloni; M Angeletti; Gloria Cristalli
Complex of dipeptidyl peptidase II with adenosine deaminase.
Biochemistry. Biokhimii͡a 2008;73(8):943-9.
2008: Gianni Sagratini; Giovanni Caprioli; Gloria Cristalli; Dario Giardiná; Massimo Ricciutelli; Rosaria Volpini; Yanting Zuo; Sauro Vittori
Determination of ink photoinitiators in packaged beverages by gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry.
Journal of chromatography. A 2008;1194(2):213-20.
2008: Gianni Sagratini; Gloria Cristalli; Dario Giardinà; Giorgio Gioventù; Filippo Maggi; Massimo Ricciutelli; Sauro Vittori
Alkannin/shikonin mixture from roots of Onosma echioides (L.) L.: extraction method study and quantification.
Journal of separation science 2008;31(6-7):945-52.
2008: Gloria Cristalli; Péter Mátyus; Peter Mohr; Giuseppe Ronsisvalle; Noël de Souza; Anna Tsantili-Kakoulidou
European medicinal chemistry education: the transformational accomplishments and challenges.
ChemMedChem 2008;3(4):561-3.
2008: Ippolito Antonini; Giorgio Santoni; Roberta Lucciarini; Consuelo Amantini; Diego Dal Ben; Rosaria Volpini; Gloria Cristalli
Synthesis and antitumor evaluation of bis aza-anthracene-9,10-diones and bis aza-anthrapyrazole-6-ones.
Journal of medicinal chemistry 2008;51(4):997-1006.
2008: Gloria Cristalli; Catia Lambertucci; G Marucci; Rosaria Volpini; Diego Dal Ben
A2A adenosine receptor and its modulators: overview on a druggable GPCR and on structure-activity relationship analysis and binding requirements of agonists and antagonists.
Current pharmaceutical design 2008;14(15):1525-52.
2007: Catia Lambertucci; Gloria Cristalli; Diego Dal Ben; Dhuldeo D Kachare; Chiara Bolcato; Karl-Norbert Klotz; Giampiero Spalluto; Rosaria Volpini
New 2,6,9-trisubstituted adenines as adenosine receptor antagonists: a preliminary SAR profile.
Purinergic signalling 2007;3(4):339-46.
2007: Anna Maria Pugliese; Elisabetta Coppi; Rosaria Volpini; Gloria Cristalli; Renato Corradetti; Lak Shin Jeong; Kenneth Alan Jacobson; Felicita Pedata
Role of adenosine A3 receptors on CA1 hippocampal neurotransmission during oxygen-glucose deprivation episodes of different duration.
Biochemical pharmacology 2007;74(5):768-79.
2007: Rosaria Volpini; Diego Dal Ben; Catia Lambertucci; Sara Taffi; Sauro Vittori; Karl-Norbert Klotz; Gloria Cristalli
N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor.
Journal of medicinal chemistry 2007;50(6):1222-30.
2007: Diego Dal Ben; Catia Lambertucci; Sara Taffi; Sauro Vittori; Rosaria Volpini; Karl-Norbert Klotz; Gloria Cristalli
Erratum to: Molecular modelling study of 2-phenylethynyladenosine (PEAdo) derivatives as highly selective A(3) adenosine receptor ligands.
Purinergic signalling 2007;3(1-2):181.
2007: Gloria Cristalli; Barbara Cacciari; Diego Dal Ben; Catia Lambertucci; Stefano Moro; Giampiero Spalluto; Rosaria Volpini
Highlights on the development of A(2A) adenosine receptor agonists and antagonists.
ChemMedChem 2007;2(3):260-81.
2007: Karl-Norbert Klotz; Nico Falgner; Sonja Kachler; Catia Lambertucci; Sauro Vittori; Rosaria Volpini; Gloria Cristalli
[3H]HEMADO--a novel tritiated agonist selective for the human adenosine A3 receptor.
European journal of pharmacology 2007;556(1-3):14-8.
2007: Catia Lambertucci; Sauro Vittori; Ram Chandra MISHRA; Diego Dal Ben; Karl-Norbert Klotz; Rosaria Volpini; Gloria Cristalli
Synthesis and biological activity of trisubstituted adenines as A 2A adenosine receptor antagonists.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1443-6.
2007: Sauro Vittori; Ram Chandra MISHRA; Diego Dal Ben; Dhuldeo Kachare; Catia Lambertucci; Rosaria Volpini; Gloria Cristalli
Synthesis and stability studies of 2',3',5'-tri-O-acetyl-2-amino(-N6-cyclopentyl)-1-deazaadenosines.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1439-42.
2006: Diego Dal Ben; Catia Lambertucci; Sara Taffi; Sauro Vittori; Rosaria Volpini; Gloria Cristalli; Karl-Norbert Klotz
Molecular modelling study of 2-phenylethynyladenosine (PEAdo) derivatives as highly selective A₃ adenosine receptor ligands.
Purinergic signalling 2006;2(4):589-94.
2006: Stefano Costanzi; Silvia Vincenzetti; Gloria Cristalli; Alberto Vita
Human cytidine deaminase: a three-dimensional homology model of a tetrameric metallo-enzyme inferred from the crystal structure of a distantly related dimeric homologue.
Journal of molecular graphics & modelling 2006;25(1):10-6.
2006: Sauro Vittori; Diego Dal Ben; Catia Lambertucci; G Marucci; Rosaria Volpini; Gloria Cristalli
Antiviral properties of deazaadenine nucleoside derivatives.
Current medicinal chemistry 2006;13(29):3529-52.
2006: Svetlana Sharoyan; Alvard Antonyan; Sona Mardanyan; Giulio Lupidi; Gloria Cristalli
Influence of dipeptidyl peptidase IV on enzymatic properties of adenosine deaminase.
Acta biochimica Polonica 2006;53(3):539-46.
2005: Rosaria Volpini; Stefano Costanzi; Catia Lambertucci; Sauro Vittori; Claudia Martini; M Letizia Trincavelli; Karl-Norbert Klotz; Gloria Cristalli
2- and 8-alkynyl-9-ethyladenines: Synthesis and biological activity at human and rat adenosine receptors.
Purinergic signalling 2005;1(2):173-81.
2005: Gloria Cristalli; Gian Marco Podda; Stefano Costanzi; Catia Lambertucci; Anna Lecchi; Sauro Vittori; Rosaria Volpini; Maddalena L Zighetti; Marco Cattaneo
Effects of 5'-phosphate derivatives of 2-hexynyl adenosine and 2-phenylethynyl adenosine on responses of human platelets mediated by P2Y receptors.
Journal of medicinal chemistry 2005;48(8):2763-6.
2005: Annalisa Pinna; Rosaria Volpini; Gloria Cristalli; Micaela Morelli
New adenosine A2A receptor antagonists: actions on Parkinson's disease models.
European journal of pharmacology 2005;512(2-3):157-64.
2005: Simone Gorzalka; Sauro Vittori; Rosaria Volpini; Gloria Cristalli; Ivar von Kügelgen; Christa E Müller
Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues.
Molecular pharmacology 2005;67(3):955-64.
2005: Sauro Vittori; Rosaria Volpini; Catia Lambertucci; Sara Taffi; Karl-Norbert Klotz; Gloria Cristalli
2-substituted 5'-N-methylcarboxamidoadenosine (MECA) derivatives as A3 adenosine receptor ligands.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):935-8.
2005: Stefano Costanzi; Catia Lambertucci; F R Portino; Rosaria Volpini; Sauro Vittori; Gloria Cristalli
Ring opening reactions: synthesis of AICAR analogs as potential antimetabolite agents.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):415-8.
2004: Ali Akbar Saboury; Soghra Bagheri; Ghasem Ataie; Massoud Amanlou; Ali Akbar Moosavi-Movahedi; Gholam Hossein Hakimelahi; Gloria Cristalli; Saeid Namaki
Binding properties of adenosine deaminase interacted with theophylline.
Chemical & pharmaceutical bulletin 2004;52(10):1179-82.
2004: Sander Woutersen; Gloria Cristalli
Strong enhancement of vibrational relaxation by Watson-Crick base pairing.
The Journal of chemical physics 2004;121(11):5381-6.
2004: Nadia D'Ambrosi; Stefano Costanzi; Daniela F Angelini; Rosaria Volpini; Giuseppe Sancesario; Gloria Cristalli; Cinzia Volonté
2-ClATP exerts anti-tumoural actions not mediated by P2 receptors in neuronal and glial cell lines.
Biochemical pharmacology 2004;67(4):621-30.
2004: Ghasem Ataie; Shahrokh Safarian; Adeleh Divsalar; Ali Akbar Saboury; Ali Akbar Moosavi-Movahedi; Bijan Ranjbar; Gloria Cristalli; S Mardanian
Kinetic and structural analysis of the inhibition of adenosine deaminase by acetaminophen.
Journal of enzyme inhibition and medicinal chemistry 2004;19(1):71-8.
2004: Sauro Vittori; Stefano Costanzi; Catia Lambertucci; F R Portino; Sara Taffi; Rosaria Volpini; Karl-Norbert Klotz; Gloria Cristalli
A2B adenosine receptor agonists: synthesis and biological evaluation of 2-phenylhydroxypropynyl adenosine and NECA derivatives.
Nucleosides, nucleotides & nucleic acids 2004;23(1-2):471-81.
2003: Silvia Vincenzetti; Giampiero De Sanctis; Stefano Costanzi; Gloria Cristalli; Pierluigi Mariani; Giampiero Mei; Jan Neuhard; Paolo Natalini; Valeria Polzonetti; Alberto Vita
Functional properties of subunit interactions in human cytidine deaminase.
Protein engineering 2003;16(12):1055-61.
2003: Karl-Norbert Klotz; Sonja Kachler; Catia Lambertucci; Sauro Vittori; Rosaria Volpini; Gloria Cristalli
9-Ethyladenine derivatives as adenosine receptor antagonists: 2- and 8-substitution results in distinct selectivities.
Naunyn-Schmiedeberg's archives of pharmacology 2003;367(6):629-34.
2003: Stefano Costanzi; Silvia Vincenzetti; Alberto Vita; Catia Lambertucci; Sara Taffi; Rosaria Volpini; Sauro Vittori; Gloria Cristalli
Human cytidine deaminase: understanding the catalytic mechanism.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1539-43.
2003: Silvia Vincenzetti; Stefano Costanzi; Gloria Cristalli; Pierluigi Mariani; B Quadrini; N Cammertoni; Alberto Vita
Intersubunit interactions in human cytidine deaminase.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1535-8.
2003: Sauro Vittori; Daniela Salvatori; Rosaria Volpini; Silvia Vincenzetti; Alberto Vita; Sara Taffi; Stefano Costanzi; Catia Lambertucci; Gloria Cristalli
Deaza- and deoxyadenosine derivatives: synthesis and inhibition of animal viruses as human infection models.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):877-81.
2003: Catia Lambertucci; Rosaria Volpini; Stefano Costanzi; Sara Taffi; Sauro Vittori; Gloria Cristalli
2-Phenylhydroxypropynyladenosine derivatives as high potent agonists at A2B adenosine receptor subtype.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):809-12.
2003: Gloria Cristalli; Stefano Costanzi; Catia Lambertucci; Sara Taffi; Sauro Vittori; Rosaria Volpini
Purine and deazapurine nucleosides: synthetic approaches, molecular modelling and biological activity.
Farmaco (Società chimica italiana : 1989) 2003;58(3):193-204.
2003: Rosaria Volpini; Stefano Costanzi; Sauro Vittori; Gloria Cristalli; Karl-Norbert Klotz
Medicinal chemistry and pharmacology of A2B adenosine receptors.
Current topics in medicinal chemistry 2003;3(4):427-43.
2003: Gloria Cristalli; Catia Lambertucci; Sara Taffi; Sauro Vittori; Rosaria Volpini
Medicinal chemistry of adenosine A2A receptor agonists.
Current topics in medicinal chemistry 2003;3(4):387-401.
2003: Stefano Costanzi; Catia Lambertucci; Sauro Vittori; Rosaria Volpini; Gloria Cristalli
2- and 8-alkynyladenosines: conformational studies and docking to human adenosine A3 receptor can explain their different biological behavior.
Journal of molecular graphics & modelling 2003;21(4):253-62.
2002: Daniela Salvatori; Rosaria Volpini; Silvia Vincenzetti; Alberto Vita; Stefano Costanzi; Catia Lambertucci; Gloria Cristalli; Sauro Vittori
Adenine and deazaadenine nucleoside and deoxynucleoside analogues: inhibition of viral replication of sheep MVV (in vitro model for HIV) and bovine BHV-1.
Bioorganic & medicinal chemistry 2002;10(9):2973-80.
2002: Rosaria Volpini; Stefano Costanzi; Catia Lambertucci; Sara Taffi; Sauro Vittori; Karl-Norbert Klotz; Gloria Cristalli
N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands.
Journal of medicinal chemistry 2002;45(15):3271-9.
2002: Sona Mardanyan; Svetlana Sharoyan; Alvard Antonyan; Giulio Lupidi; Gloria Cristalli
Interaction of adenosine deaminase with inhibitors. Chemical modification by diethyl pyrocarbonate.
Biochemistry. Biokhimii͡a 2002;67(7):770-7.
2002: Rosaria Volpini; Stefano Costanzi; Catia Lambertucci; Sauro Vittori; Gloria Cristalli
Purine nucleosides bearing 1-alkynyl chains as adenosine receptor agonists.
Current pharmaceutical design 2002;8(26):2285-98.
2001: Rosaria Volpini; Stefano Costanzi; Catia Lambertucci; Sauro Vittori; K Klotz; Anna Lorenzen; Gloria Cristalli
Introduction of alkynyl chains on C-8 of adenosine led to very selective antagonists of the A(3) adenosine receptor.
Bioorganic & medicinal chemistry letters 2001;11(14):1931-4.
2001: Rosaria Volpini; Stefano Costanzi; Catia Lambertucci; Sauro Vittori; Gloria Cristalli
Synthetic procedure for the preparation of novel potent and selective A3 adenosine receptor radioligands.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):775-9.
2001: Sauro Vittori; Stefano Costanzi; Catia Lambertucci; Rosaria Volpini; Gloria Cristalli
Coupling of 2,6-disubstituted purines to ribose-modified sugars.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):771-4.
2001: Catia Lambertucci; Stefano Costanzi; Sauro Vittori; Rosaria Volpini; Gloria Cristalli
Synthesis and adenosine receptor affinity and potency of 8-alkynyl derivatives of adenosine.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):1153-7.
2001: Stefano Costanzi; Catia Lambertucci; Rosaria Volpini; Sauro Vittori; Giulio Lupidi; Gloria Cristalli
3'-deoxyribofuranose derivatives of 1-deaza and 3-deaza-adenosine and their activity as adenosine deaminase inhibitors.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):1037-41.
2001: Sona Mardanyan; Svetlana Sharoyan; Alvard Antonyan; A Armenyan; Gloria Cristalli; Giulio Lupidi
Tryptophan environment in adenosine deaminase. I. Enzyme modification with N-bromosuccinimide in the presence of adenosine and EHNA analogues.
Biochimica et biophysica acta 2001;1546(1):185-95.
2001: Gloria Cristalli; Stefano Costanzi; Catia Lambertucci; Giulio Lupidi; Sauro Vittori; Rosaria Volpini; E Camaioni
Adenosine deaminase: functional implications and different classes of inhibitors.
Medicinal research reviews 2001;21(2):105-28.
2000: Sauro Vittori; Anna Lorenzen; Christina Stannek; Stefano Costanzi; Rosaria Volpini; Adriaan P IJzerman; J K Kunzel; Gloria Cristalli
N-cycloalkyl derivatives of adenosine and 1-deazaadenosine as agonists and partial agonists of the A(1) adenosine receptor.
Journal of medicinal chemistry 2000;43(2):250-60.
1999: Rosaria Volpini; E Camaioni; Stefano Costanzi; Sauro Vittori; Karl-Norbert Klotz; Gloria Cristalli
Synthesis of di- and tri-substituted adenosine derivatives and their affinities at human adenosine receptor subtypes.
Nucleosides & nucleotides 1999;18(11-12):2511-20.
1999: Karl-Norbert Klotz; E Camaioni; Rosaria Volpini; Sonja Kachler; Sauro Vittori; Gloria Cristalli
2-Substituted N-ethylcarboxamidoadenosine derivatives as high-affinity agonists at human A3 adenosine receptors.
Naunyn-Schmiedeberg's archives of pharmacology 1999;360(2):103-8.
1999: Nandanan Erathodiyil; E Camaioni; SY Jang; YC Kim; Gloria Cristalli; Piet Herdewijn; John A Secrist; Kamal N Tiwari; A Mohanram; T Kendall Harden; José L Boyer; Kenneth Alan Jacobson
Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists.
Journal of medicinal chemistry 1999;42(9):1625-38.
1999: André Bergman; Gloria Cristalli; Sauro Vittori; J Wang; S Eriksson; Godefridus J Peters
Biological activity of 1-deazapurine nucleosides: role of deoxycytidine kinase?
Nucleosides & nucleotides 1999;18(4-5):897-8.
1999: Sauro Vittori; E Camaioni; Stefano Costanzi; Rosaria Volpini; Karl-Norbert Klotz; Gloria Cristalli
Synthesis and receptor affinity of polysubstituted adenosines.
Nucleosides & nucleotides 1999;18(4-5):739-40.
1998: Giulio Lupidi; F Marmocchi; Gloria Cristalli
Inhibition studies on membrane adenosine deaminase from human placenta.
Biochemistry and molecular biology international 1998;46(6):1071-80.
1998: D Barbieri; Claudio Franceschi; E Camaioni; Stefano Costanzi; Sauro Vittori; Rosaria Volpini; Gloria Cristalli
Modulation of apoptosis in human lymphocytes by adenosine analogues.
Bioorganic & medicinal chemistry letters 1998;8(18):2533-8.
1998: Pier Giovanni Baraldi; Barbara Cacciari; Maria Josè Pineda de las Infantas; LUISA-CARLOTA LÓPEZ-CARA; Giampiero Spalluto; Rosaria Volpini; Stefano Costanzi; Sauro Vittori; Gloria Cristalli; Neli Melman; K S Park; Xiao-Duo Ji; Kenneth Alan Jacobson
Synthesis and biological activity of a new series of N6-arylcarbamoyl, 2-(Ar)alkynyl-N6-arylcarbamoyl, and N6-carboxamido derivatives of adenosine-5'-N-ethyluronamide as A1 and A3 adenosine receptor agonists.
Journal of medicinal chemistry 1998;41(17):3174-85.
1998: E Camaioni; Stefano Costanzi; Sauro Vittori; Rosaria Volpini; Karl-Norbert Klotz; Gloria Cristalli
New substituted 9-alkylpurines as adenosine receptor ligands.
Bioorganic & medicinal chemistry 1998;6(5):523-33.
1997: E Camaioni; E Di Francesco; Sauro Vittori; Rosaria Volpini; Gloria Cristalli
Adenosine receptor agonists: synthesis and biological evaluation of the diastereoisomers of 2-(3-hydroxy-3-phenyl-1-propyn-1-yl)NECA.
Bioorganic & medicinal chemistry 1997;5(12):2267-75.
1997: Giulio Lupidi; F Marmocchi; G Venardi; Gloria Cristalli
Functional residues at the active site of bovine brain adenosine deaminase.
Biochemistry and molecular biology international 1997;43(6):1339-52.
1997: Rosaria Volpini; E Camaioni; Giulio Lupidi; Sauro Vittori; Gloria Cristalli
Adenosine deaminase inhibitors: synthesis, diastereoisomeric resolution and biological activity of 1-(2-hydroxy-3-nonyl)-1,2,4-triazole-3-carboxamide.
Farmaco (Società chimica italiana : 1989) 1997;52(6-7):429-33.
1996: Sauro Vittori; E Camaioni; E Di Francesco; Rosaria Volpini; Angela Monopoli; S Dionisotti; Ennio Ongini; Gloria Cristalli
2-alkenyl and 2-alkyl derivatives of adenosine and adenosine-5'-N-ethyluronamide: different affinity and selectivity of E- and Z-diastereomers at A2A adenosine receptors.
Journal of medicinal chemistry 1996;39(21):4211-7.
1995: Maria Elena Marongiu; Alessandra Pani; E Tinti; Mario Grifantini; Palmarisa Franchetti; Gloria Cristalli; Paolo La Colla
Enhancement of the anti-HIV-1 activity of ddAdo by coformycin, EHNA and deaza-EHNA derivatives.
The new microbiologica 1995;18(4):359-70.
1995: Gloria Cristalli; Sauro Vittori; Anna Maria Eleuteri; Rosaria Volpini; E Camaioni; Giulio Lupidi; N Mahmood; F Bevilacqua; Giorgio Palù
Synthesis and biological evaluation of N6-cycloalkyl derivatives of 1-deazaadenine nucleosides: a new class of anti-human immunodeficiency virus agents.
Journal of medicinal chemistry 1995;38(20):4019-25.
1995: Gloria Cristalli; E Camaioni; Sauro Vittori; Rosaria Volpini; P A Borea; A Conti; S Dionisotti; Ennio Ongini; Angela Monopoli
2-Aralkynyl and 2-heteroalkynyl derivatives of adenosine-5'-N-ethyluronamide as selective A2a adenosine receptor agonists.
Journal of medicinal chemistry 1995;38(9):1462-72.
1995: S M Siddiqi; Kenneth Alan Jacobson; J L Esker; ME Olah; Xiao-Duo Ji; Neli Melman; Kamal N Tiwari; John A Secrist; Stewart W Schneller; Gloria Cristalli
Search for new purine- and ribose-modified adenosine analogues as selective agonists and antagonists at adenosine receptors.
Journal of medicinal chemistry 1995;38(7):1174-88.
1994: Angela Monopoli; A Conti; S Dionisotti; C Casati; E Camaioni; Gloria Cristalli; Ennio Ongini
Pharmacology of the highly selective A1 adenosine receptor agonist 2-chloro-N6-cyclopentyladenosine.
Arzneimittel-Forschung 1994;44(12):1305-12.
1994: Angela Monopoli; A Conti; C Zocchi; C Casati; Rosaria Volpini; Gloria Cristalli; Ennio Ongini
Pharmacology of the new selective A2a adenosine receptor agonist 2-hexynyl-5'-N-ethylcarboxamidoadenosine.
Arzneimittel-Forschung 1994;44(12):1296-304.
1994: Gloria Cristalli; Sauro Vittori; R D Thompson; W L Padgett; D Shi; John W Daly; R A Olsson
Inhibition of platelet aggregation by adenosine receptor agonists.
Naunyn-Schmiedeberg's archives of pharmacology 1994;349(6):644-50.
1994: Gloria Cristalli; Rosaria Volpini; Sauro Vittori; E Camaioni; Angela Monopoli; A Conti; S Dionisotti; C Zocchi; Ennio Ongini
2-Alkynyl derivatives of adenosine-5'-N-ethyluronamide: selective A2 adenosine receptor agonists with potent inhibitory activity on platelet aggregation.
Journal of medicinal chemistry 1994;37(11):1720-6.
1994: Gloria Cristalli; Anna Maria Eleuteri; Rosaria Volpini; Sauro Vittori; E Camaioni; Giulio Lupidi
Adenosine deaminase inhibitors: synthesis and structure-activity relationships of 2-hydroxy-3-nonyl derivatives of azoles.
Journal of medicinal chemistry 1994;37(1):201-5.
1992: Giulio Lupidi; F Marmocchi; M Falasca; G Venardi; Gloria Cristalli; Mario Grifantini; E Whitehead; F Riva
Adenosine deaminase from Saccharomyces cerevisiae: kinetics and interaction with transition and ground state inhibitors.
Biochimica et biophysica acta 1992;1122(3):311-6.
1992: Gloria Cristalli; Anna Maria Eleuteri; Sauro Vittori; Rosaria Volpini; M J Lohse; Karl-Norbert Klotz
2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors.
Journal of medicinal chemistry 1992;35(13):2363-8.
1992: Giulio Lupidi; M Falasca; F Marmocchi; G Venardi; Gloria Cristalli; F Riva
Adenosine deaminase from bovine brain: purification and partial characterization.
Biochemistry international 1992;26(6):1053-63.
1991: Gloria Cristalli; Sauro Vittori; Anna Maria Eleuteri; Mario Grifantini; Rosaria Volpini; Giulio Lupidi; L Capolongo; E Pesenti
Purine and 1-deazapurine ribonucleosides and deoxyribonucleosides: synthesis and biological activity.
Journal of medicinal chemistry 1991;34(7):2226-30.
1991: Gloria Cristalli; Anna Maria Eleuteri; Palmarisa Franchetti; Mario Grifantini; Sauro Vittori; Giulio Lupidi
Adenosine deaminase inhibitors: synthesis and structure-activity relationships of imidazole analogues of erythro-9-(2-hydroxy-3-nonyl)adenine.
Journal of medicinal chemistry 1991;34(3):1187-92.
1991: Mario Grifantini; Gloria Cristalli; Palmarisa Franchetti; Sauro Vittori
Adenosine derivatives as agonists of adenosine receptors.
Farmaco (Società chimica italiana : 1989) 1991;46(1 Suppl):161-9.
1990: Palmarisa Franchetti; Gloria Cristalli; Mario Grifantini; Loredana Cappellacci; Sauro Vittori; Giuseppe Nocentini
Synthesis and antitumor activity of 2-beta-D-ribofuranosyloxazole-4-carboxamide (oxazofurin).
Journal of medicinal chemistry 1990;33(10):2849-52.
1989: Karl-Norbert Klotz; M J Lohse; Ulrich Schwabe; Gloria Cristalli; Sauro Vittori; Mario Grifantini
2-Chloro-N6-[3H]cyclopentyladenosine ([3H]CCPA)--a high affinity agonist radioligand for A1 adenosine receptors.
Naunyn-Schmiedeberg's archives of pharmacology 1989;340(6):679-83.
1989: Gloria Cristalli; Palmarisa Franchetti; Mario Grifantini; Giuseppe Nocentini; Sauro Vittori
3,7-Dideazapurine nucleosides. Synthesis and antitumor activity of 1-deazatubercidin and 2-chloro-2'-deoxy-3,7-dideazaadenosine.
Journal of medicinal chemistry 1989;32(7):1463-6.
1988: Gloria Cristalli; Palmarisa Franchetti; Mario Grifantini; Sauro Vittori; Karl-Norbert Klotz; M J Lohse
Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives.
Journal of medicinal chemistry 1988;31(6):1179-83.
1988: M J Lohse; Karl-Norbert Klotz; Ulrich Schwabe; Gloria Cristalli; Sauro Vittori; Mario Grifantini
2-Chloro-N6-cyclopentyladenosine: a highly selective agonist at A1 adenosine receptors.
Naunyn-Schmiedeberg's archives of pharmacology 1988;337(6):687-9.
1988: Gloria Cristalli; Palmarisa Franchetti; Mario Grifantini; Sauro Vittori; Giulio Lupidi; F Riva; T Bordoni; Cristina Geroni; M A Verini
Adenosine deaminase inhibitors. Synthesis and biological activity of deaza analogues of erythro-9-(2-hydroxy-3-nonyl)adenine.
Journal of medicinal chemistry 1988;31(2):390-3.
1988: Ippolito Antonini; F Claudi; Gloria Cristalli; Palmarisa Franchetti; Mario Grifantini; Sante Martelli
Heterocyclic quinones with potential antitumor activity. 2. Synthesis and antitumor activity of some benzimidazole-4,7-dione derivatives.
Journal of medicinal chemistry 1988;31(1):260-4.
1987: Gloria Cristalli; Palmarisa Franchetti; Mario Grifantini; Sauro Vittori; T Bordoni; Cristina Geroni
Improved synthesis and antitumor activity of 1-deazaadenosine.
Journal of medicinal chemistry 1987;30(9):1686-8.
1987: L Silvotti; Giuseppe Piedimonte; Gloria Cristalli; Mario Grifantini; P Galiotta; Flaminio Nicola Cattabeni; O Cantoni
The effect of deazaadenosine analogues on the proliferation rate of cultured Vero cells.
Pharmacological research communications 1987;19(5):359-66.
1986: Gloria Cristalli; Palmarisa Franchetti; Mario Grifantini; S Ripa
2,2'-Bipyridyl-6-carboxamidoximes with potential antitumor and antimicrobial properties.
Il Farmaco; edizione scientifica 1986;41(7):499-507.
1986: F Claudi; Gloria Cristalli; Sante Martelli; V Perlini; M Massi; F Venturi
Synthesis and dopaminergic activity of trans-6-methyl-7a,8,9,10,11,11a-hexahydro-7H-pyrrolo[3,2,1-gh]- 4,7-phenanthroline and trans-1,2,3,4,4a,5,6,10b-octahydro-4,7-phenanthroline derivatives.
Journal of medicinal chemistry 1986;29(6):1061-5.
1986: Ippolito Antonini; Gloria Cristalli; Palmarisa Franchetti; Mario Grifantini; Sante Martelli; S Filippeschi
2,2'-Bipyridyl-6-carbothioamide derivatives as potential antitumor agents.
Il Farmaco; edizione scientifica 1986;41(5):346-54.
1986: O Cantoni; Giuseppe Piedimonte; P Sestili; W Balduini; Gloria Cristalli; Mario Grifantini; Flaminio Nicola Cattabeni
1,3 dideazaadenosine is a mitogen for cultured mammalian cells.
Pharmacological research communications 1986;18(4):333-42.
1985: O Cantoni; P Sestili; W Balduini; Gloria Cristalli; Mario Grifantini; Flaminio Nicola Cattabeni
Inhibition of nucleic acids and protein synthesis by deazaadenosine derivatives: a study on structure-activity relationships.
Pharmacological research communications 1985;17(12):1087-94.
1985: Karl-Norbert Klotz; Gloria Cristalli; Mario Grifantini; Sauro Vittori; M J Lohse
Photoaffinity labeling of A1-adenosine receptors.
The Journal of biological chemistry 1985;260(27):14659-64.
1985: Giulio Lupidi; Gloria Cristalli; F Marmocchi; F Riva; Mario Grifantini
Inhibition of adenosine deaminase from several sources by deaza derivatives of adenosine and EHNA.
Journal of enzyme inhibition 1985;1(1):67-75.
1984: Ippolito Antonini; Gloria Cristalli; Palmarisa Franchetti; Mario Grifantini; Sante Martelli; Giulio Lupidi; F Riva
Adenosine deaminase inhibitors. Synthesis of deaza analogues of erythro-9-(2-hydroxy-3-nonyl)adenine.
Journal of medicinal chemistry 1984;27(3):274-8.
1982: Giulio Lupidi; F Riva; Gloria Cristalli; Mario Grifantini
Inhibition of adenosine deaminase by deaza derivatives of adenosine and purine riboside.
The Italian journal of biochemistry 1982;31(6):396-403.
1982: Ippolito Antonini; F Claudi; Gloria Cristalli; Palmarisa Franchetti; Mario Grifantini; Sante Martelli
Synthesis of 4-amino-1-beta-D-ribofuranosyl-1H-pyrrolo[2,3-b]pyridine (1-deazatubercidin) as a potential antitumor agent.
Journal of medicinal chemistry 1982;25(10):1258-61.
1981: Ippolito Antonini; F Claudi; Gloria Cristalli; Palmarisa Franchetti; Mario Grifantini; Sante Martelli
N*-N*-S* tridentate ligand system as potential antitumor agents.
Journal of medicinal chemistry 1981;24(10):1181-4.