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Thierry Brun

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Ning Li; Xiao-Juan Ma; Zahia Mahiout; Thierry Brun; Youssef Daali; Christine Deffert-Delbouille; Karl-Heinz Krause; Bin Li; Pierre Maechler
NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion.
Sachin Supale; Thierry Brun; Ning Li; Pierre Maechler
Mitochondrial dysfunction in pancreatic β cells.
Kai Hui Hu He; Jorge Vallejo Ortega; Petra Isabel Lorenzo; Thierry Brun; Carmen M Jimenez Moreno; Deborah Aeberhard; Marion Cornu; Fabrizio Thorel; Asllan Gjinovci; Bernard Thorens; Pedro L Herrera; Paolo Meda; Claes B Wollheim; Benoit R Gauthier
In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice.

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2012: Ning Li; Xiao-Juan Ma; Zahia Mahiout; Thierry Brun; Youssef Daali; Christine Deffert-Delbouille; Karl-Heinz Krause; Bin Li; Pierre Maechler
NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion.
Diabetes 2012;61(11):2842-50.
2012: Sachin Supale; Thierry Brun; Ning Li; Pierre Maechler
Mitochondrial dysfunction in pancreatic β cells.
Trends in endocrinology and metabolism: TEM 2012;23(9):477-87.
2011: Kai Hui Hu He; Jorge Vallejo Ortega; Petra Isabel Lorenzo; Thierry Brun; Carmen M Jimenez Moreno; Deborah Aeberhard; Marion Cornu; Fabrizio Thorel; Asllan Gjinovci; Bernard Thorens; Pedro L Herrera; Paolo Meda; Claes B Wollheim; Benoit R Gauthier
In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice.
Diabetes 2011;60(6):1705-15.
2011: Laurène Vetterli; Thierry Brun; Laurianne Giovannoni; Domenico Bosco; Pierre Maechler
Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism.
The Journal of biological chemistry 2011;286(8):6049-60.
2010: F Frigerio; Thierry Brun; Clarissa Bartley; Alessia Usardi; Domenico Bosco; K Ravnskjaer; Susanne Mandrup; Pierre Maechler
Peroxisome proliferator-activated receptor alpha (PPARalpha) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism.
Diabetologia 2010;53(2):331-40.
2010: Pierre Maechler; Ning Li; Marina Casimir; Laurène Vetterli; Francesca Frigerio; Thierry Brun
Role of mitochondria in beta-cell function and dysfunction.
Advances in experimental medicine and biology 2010;654():193-216.
2009: Ning Li; Thierry Brun; Miriam Cnop; Daniel Cunha; Decio L Eizirik; Pierre Maechler
Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction.
The Journal of biological chemistry 2009;284(35):23602-12.
2008: Thierry Brun; Roberto Lupi; Bernhard Boehm; Anne Wojtusciszyn; Nadine Sauter; Marc Y Donath; Piero Marchetti; Kathrin Maedler; Kai Hui Hu He; Benoit R Gauthier
The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1.
Human molecular genetics 2008;17(4):478-89.
2008: Thierry Brun; Benoit R Gauthier
A focus on the role of Pax4 in mature pancreatic islet beta-cell expansion and survival in health and disease.
Journal of molecular endocrinology 2008;40(2):37-45.
2007: Thierry Brun; D L Duhamel; K H Hu He; Claes B Wollheim; Benoit R Gauthier
The transcription factor PAX4 acts as a survival gene in INS-1E insulinoma cells.
Oncogene 2007;26(29):4261-71.
2007: Haiyan Wang; Thierry Brun; K Kataoka; A J Sharma; Claes B Wollheim
MAFA controls genes implicated in insulin biosynthesis and secretion.
Diabetologia 2007;50(2):348-58.
2007: Dominique A Glauser; Thierry Brun; Benoit R Gauthier; Werner Schlegel
Transcriptional response of pancreatic beta cells to metabolic stimulation: large scale identification of immediate-early and secondary response genes.
BMC molecular biology 2007;8():54.
2005: Anna Biason-Lauber; B Boehm; Mariarosaria Lang-Muritano; Benoit R Gauthier; Thierry Brun; Claes B Wollheim; Eugen J Schoenle
Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity.
Diabetologia 2005;48(5):900-5.
2005: Thierry Brun; Claes B Wollheim; Benoit R Gauthier
[Pax4, islet plasticity and diabetes].
Médecine sciences : M/S 2005;21(4):358-9.
2005: Beate Ritz-Laser; Aline Mamin; Thierry Brun; Isabelle Avril; Valerie M Schwitzgebel; Jacques Philippe
The zinc finger-containing transcription factor Gata-4 is expressed in the developing endocrine pancreas and activates glucagon gene expression.
Molecular endocrinology (Baltimore, Md.) 2005;19(3):759-70.
2004: Thierry Brun; Isobel Franklin; Luc St-Onge; Anna Biason-Lauber; Eugen J Schoenle; Claes B Wollheim; Benoit R Gauthier
The diabetes-linked transcription factor PAX4 promotes {beta}-cell proliferation and survival in rat and human islets.
The Journal of cell biology 2004;167(6):1123-35.
2004: Benoit R Gauthier; Thierry Brun; Eve Julie Sarret; Hisamitsu Ishihara; Olivier Schaad; Patrick Descombes; Claes B Wollheim
Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets.
The Journal of biological chemistry 2004;279(30):31121-30.
2003: Valerie M Schwitzgebel; Aline Mamin; Thierry Brun; Beate Ritz-Laser; Maia Zaiko; Alexandre Maret; François R Jornayvaz; Gérald E Theintz; Olivier Michielin; Danielle Melloul; Jacques Philippe
Agenesis of human pancreas due to decreased half-life of insulin promoter factor 1.
The Journal of clinical endocrinology and metabolism 2003;88(9):4398-406.
2003: Beate Ritz-Laser; Benoit R Gauthier; Anne Estreicher; Aline Mamin; Thierry Brun; Frédéric Ris; P Salmon; Philippe A Halban; D Trono; Jacques Philippe
Ectopic expression of the beta-cell specific transcription factor Pdx1 inhibits glucagon gene transcription.
Diabetologia 2003;46(6):810-21.
2001: Delphine Germain-Desprez; Thierry Brun; Camille Rochette; A Semionov; R Rouget; Louise R Simard
The SMN genes are subject to transcriptional regulation during cellular differentiation.
Gene 2001;279(2):109-17.
1999: CJ DiDonato; Thierry Brun; Louise R Simard
Complete nucleotide sequence, genomic organization, and promoter analysis of the murine survival motor neuron gene (Smn).
Mammalian genome : official journal of the International Mammalian Genome Society 1999;10(6):638-41.
1998: Geneviève Trottier; K G Koski; Thierry Brun; Donna J Toufexis; Denis Richard; Claire-Dominique Walker
Increased fat intake during lactation modifies hypothalamic-pituitary-adrenal responsiveness in developing rat pups: a possible role for leptin.
Endocrinology 1998;139(9):3704-11.
1998: E Roche; S Farfari; L A Witters; Françoise Assimacopoulos-Jeannet; S Thumelin; Thierry Brun; Barbara E Corkey; Asish K Saha; Marc Prentki
Long-term exposure of beta-INS cells to high glucose concentrations increases anaplerosis, lipogenesis, and lipogenic gene expression.
Diabetes 1998;47(7):1086-94.
1998: Marc Prentki; L Segall; E Roche; S Thumelin; Thierry Brun; J Denis McGarry; Barbara E Corkey; Françoise Assimacopoulos-Jeannet
[Gluco-lipotoxicity and gene expression in the pancreatic beta cell].
Journées annuelles de diabétologie de l'Hôtel-Dieu 1998;():17-27.
1997: Frans Schuit; Anick De Vos; S Farfari; Karen Moens; Daniel Pipeleers; Thierry Brun; Marc Prentki
Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells.
The Journal of biological chemistry 1997;272(30):18572-9.
1997: Thierry Brun; Françoise Assimacopoulos-Jeannet; Barbara E Corkey; Marc Prentki
Long-chain fatty acids inhibit acetyl-CoA carboxylase gene expression in the pancreatic beta-cell line INS-1.
Diabetes 1997;46(3):393-400.
1996: Thierry Brun; E Roche; Françoise Assimacopoulos-Jeannet; Barbara E Corkey; K H Kim; Marc Prentki
Evidence for an anaplerotic/malonyl-CoA pathway in pancreatic beta-cell nutrient signaling.
Diabetes 1996;45(2):190-8.
1994: Marc Prentki; Thierry Brun; E Roche
[Nutriments, insulin secretion and gene expression in the pancreatic beta cell].
Journées annuelles de diabétologie de l'Hôtel-Dieu 1994;():1-11.
1993: Thierry Brun; E Roche; K H Kim; Marc Prentki
Glucose regulates acetyl-CoA carboxylase gene expression in a pancreatic beta-cell line (INS-1).
The Journal of biological chemistry 1993;268(25):18905-11.